175 results on '"SAVARY, G."'
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2. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, L, Alonso-Arias, R, Arias, A, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, Y, Bustos, I, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaibi, K, Colobran, R, Condino-Neto, A, Covill, L, Delmonte, O, El Zein, L, Flores, C, Gregersen, P, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarstrom, L, Hatipoglu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, J, Mansouri, D, Martinez-Picado, J, Metin Akcan, O, Migeotte, I, Morange, P, Morelle, G, Martin-Nalda, A, Novelli, G, Novelli, A, Palabiyik, F, Pan-Hammarstrom, Q, de Diego, R, Planas-Serra, L, Pleguezuelo, D, Prando, C, Pujol, A, Reyes, L, Riviere, J, Rodriguez-Gallego, C, Rojas, J, Rovere-Querini, P, Schluter, A, Shahrooei, M, Sobh, A, Soler-Palacin, P, Tandjaoui-Lambiotte, Y, Tipu, I, Tresoldi, C, Troya, J, van de Beek, D, Zatz, M, Zawadzki, P, Al-Muhsen, S, Alosaimi, M, Alsohime, F, Baris-Feldman, H, Butte, M, Constantinescu, S, Cooper, M, Dalgard, C, Fellay, J, Heath, J, Lau, Y, Lifton, R, Maniatis, T, Mogensen, T, von Bernuth, H, Lermine, A, Vidaud, M, Boland, A, Deleuze, J, Nussbaum, R, Kahn-Kirby, A, Mentre, F, Tubiana, S, Gorochov, G, Tubach, F, Hausfater, P, Al-Mulla, F, Anderson, M, Andreakos, E, Feldman, H, Belot, A, Biggs, C, Bogunovic, D, Bondarenko, A, Bousfiha, A, Brodin, P, Bustamante, C, Chakravorty, S, Christodoulou, J, Desai, M, Drolet, B, Baghdadi, J, Espinosa-Padilla, S, Froidure, A, Hagin, D, Henrickson, S, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jarvis, E, Karamitros, T, Kisand, K, Ku, C, Ling, Y, Lucas, C, Marodi, L, Milner, J, Mironska, K, Morio, T, Ng, L, O'Farrelly, C, Okada, S, Planas, A, Quintana-Murci, L, Renia, L, Resnick, I, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shcherbina, A, Slaby, O, Snow, A, Spaan, A, Tancevski, I, Tangye, S, Ramaswamy, S, Turvey, S, Uddin, F, Uddin, M, Vinh, D, Casanova, J, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Chachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, Chauvin, C, Chavarot, N, Chebbout, K, Cherai, M, Cherubini, I, Chevalier, A, Chiarabini, T, Chinet, T, Chocron, R, Choinier, P, Chommeloux, J, Choquet, C, Choupeaux, L, Chousterman, B, Ciocan, D, Clarke, A, Clavere, G, Clavier, F, Clement, K, Clerc, S, Cohen, Y, Cohen, F, Cohen, A, Coilly, A, Colboc, H, Colin, P, Collet, M, Comarmond, C, Combacon, E, Combes, A, Comparon, C, Constantin, J, Cordel, H, Cordier, A, Costantini, A, Chalumeau, N, Couffignal, C, Coupeau, D, Creange, A, Lamarre, Y, Da Silveira, C, Kayani, S, De Castro, N, De Rycke, Y, Del Pozo, L, Delannoy, Q, Delay, M, Deleris, R, Delforge, J, Delphine, L, Demare, N, Demeret, S, Demoule, A, Deniau, A, Depret, F, Derolez, S, Derradji, O, Derridj, N, Descamps, V, Deschamps, L, Desconclois, C, Desnos, C, Desongins, K, Dhote, R, Diallo, B, Didier, M, Diemer, M, Diez, S, Djadi-Prat, J, Monnory, F, Djebara, S, Djebra, N, Djietcheu, M, Djillali, H, Djouadi, N, Donneger, S, Dos Santos, C, Dournon, N, Dres, M, Droctove, L, Drogrey, M, Dropy, M, Drouet, E, Dubosq, V, Dubreucq, E, Dubus, E, Duchemann, B, Duchenoy, T, Dudoignon, E, Dufau, R, Dumas, F, Duran, C, Duron, E, Durrbach, A, Duvivier, C, Ebstein, N, Khalifa, J, Elabbadi, A, Elie, C, Ernotte, G, Esling, A, Etienne, M, Eyer, X, Fartoukh, M, Fayali, T, Fermaut, M, Fiorentino, A, Fliss, S, Fournier, M, Fournier, B, Francois, H, Freynet, O, Frigout, Y, Fromont, I, Fuentes, A, Furet, T, Galand, J, Garnier, M, Gaubert, A, Gaudry, S, Gaugain, S, Gauthier, D, Gautier, M, Georgin-Lavialle, S, Geromin, D, Ghalayini, M, Ghaleh, B, Ghezal, M, Gibelin, A, Gimeno, L, Girard, B, Leprieur, B, Gomes, D, Gomes-Pires, E, Gouge, A, Gouja, A, Goulet, H, Goupil, S, De Bouille, J, Gras, J, Greffe, S, Grimaldi, L, Guedeney, P, Guidet, B, Guillo, M, Gulczynski, M, Hadjam, T, Haguenauer, D, Hammal, S, Hammoudi, N, Hanon, O, Harrois, A, Hautem, C, Hekimian, G, Heming, N, Hermine, O, Ho, S, Houllier, M, Huot, B, Huscenot, T, Saied, W, Ikherbane, G, Imarazene, M, Ingiliz, P, Iratni, L, Jaureguiberry, S, Jean-Marc, J, Jeyarajasingham, D, Jouany, P, Jouis, V, Jourdaine, C, Kafif, O, Kallala, R, Katsahian, S, Kelesyan, L, Keo, V, Ketz, F, Khamis, W, Khelili, E, Khellaf, M, Youkou, C, Kounis, I, Kpalma, G, Krause, J, Labbe, V, Lacombe, K, Lacorte, J, Lafont, A, Lafont, E, Lagha, L, Lamhaut, L, Lancelot, A, Landman, C, Lanternier, F, Larcheveque, C, Combe, C, Lassel, L, Laverdant, B, Lavergne, C, Lavillegrand, J, Lazureanu, P, Le Guennec, L, Leberre, L, Leblanc, C, Leboyer, M, Lecomte, F, Lecorre, M, Leenhardt, R, Lefebvre, M, Lefebvre, B, Legendre, P, Leger, A, Legros, L, Legrosse, J, Lehuunghia, S, Lemarec, J, Leporrier-Ext, J, Lesein, M, Lesur, H, Levy, V, Levy, A, Lopes, E, Lopes, A, Lopez, V, Lopinto, J, Lortholary, O, Louadah, B, Loze, B, Lucas, M, Lucasamichi, A, Luong, L, Magazimama-Ext, A, Maingret, D, Mameri, L, Manivet, P, Mansouri, C, Marcault, E, Marey, J, Marin, N, Marois, C, Martin, O, Martineau, L, Martinez-Lopez, C, Martyniuck, P, De Farcy, P, Marzouk, N, Masmoudi, R, Mebazaa, A, Mechai, F, Mecozzi, F, Mediouni, C, Megarbane, B, Meghadecha, M, Mejean, E, Mekinian, A, Abdelhadi, N, Mekni, R, Meliti, T, Lima, B, Meng, P, Merbah, S, Messani, F, Messaoudi, Y, Mewasing, B, Meziane, L, Michelot-Burger, C, Mignot, F, Minka, F, Miyara, M, Moine, P, Molina, J, Montegnies-Boulet, A, Monti, A, Montlahuc, C, Montout, A, Moores, A, Morbieu, C, Mortelette, H, Mouly, S, Muzaffar, R, Nacerddine, C, Nadal, M, Nadif, H, Nassarmadji, K, Natella, P, Ndingamondze, S, Neraal, S, Nguyen, C, N'Guyen, B, Larmurier, I, Nlomenyengue, L, Noel, N, Nunes, H, Omar, E, Ouazene, Z, Ouedraogo, E, Ouelaa, W, Oukhedouma, A, Amara, Y, Oya, H, Oziel, J, Padilla, T, Paillaud, E, Paiva, S, Parfait, B, Parize, P, Parizot, C, Parrot, A, Pavot, A, Peaudecerf, L, Pene, F, Pepin, M, Pernet, J, Pernin, C, Petit, M, Peyrony, O, Pietri, M, Pietri, O, De Chambrun, M, Pinson, M, Pintado, C, Pires, C, Planquette, B, Poirier, S, Pomel, A, Pons, S, Ponscarme, D, Pourcelot, A, Pourcher, V, Pouvaret, A, Prever, F, Previlon, M, Prevost, M, Provoost, M, Quemeneur, C, Rafat, C, Rami, A, Ranque, B, Raphael, M, Raphalen, J, Rastoin, A, Raux, M, Rebai, A, Reby, M, Regent, A, Regrag, A, Resche-Rigon, M, Ressaire, Q, Richard, C, Richard, M, Robert, M, Rohaut, B, Rolland-Debord, C, Ropers, J, Roque-Afonso, A, Rosso, C, Rousseaux, M, Rousseaux, N, Roux, S, Roux, L, Rouzaud, C, Rozes, A, Rubenstein, E, Sabate, J, Sabet, S, Sacleux, S, Kermanach, N, Saliba, F, Salmon, D, Savale, L, Savary, G, Sberro, R, Scemla, A, Schlemmer, F, Schwartz, M, Sedfi, S, Sefir-Kribel, S, Seksik, P, Sellier, P, Selves, A, Sembach, N, Semerano, L, Senat, M, Sene, D, Serris, A, Sese, L, Sghiouar, N, Sigaux, J, Siguier, M, Silvain, J, Simon, N, Simon, T, Skandri, L, Slimani, M, Snauwaert, A, Sokol, H, Soliman, H, Soltani, N, Soyer, B, Steg, G, Suarez, L, Szwebel, T, Taffame, K, Tantet, C, Tateo, M, Theodose, I, Thiebaud, P, Thomas, C, Tiercelet, K, Tisserand, J, Tomczak, C, Torelino, K, Touam-Ext, F, Toumi, L, Toury, G, Toy-Miou, M, Lien, O, Trandinh, A, Treluyer, J, Trinque, B, Truchot, J, Tunesi, S, Turpin, M, Turpin, A, Urbina, T, Narvaez, R, Uzunhan, Y, Vaittinadaayar, P, Valent, A, Valentian, M, Valin, N, Vallet, H, Vaz, M, Vazquezibarra, M, Vedie, B, Velly, L, Verstuyft, C, Viallette, C, Vicaut, E, Vignes, D, Vimpere, D, Virlouvet, M, Voiriot, G, Voisot, L, Weiss, E, Weiss, N, Winchenne, A, Yordanov, Y, Zafrani, L, Zaidan, M, Zaidi, W, Zak, C, Zarhrate-Ghoul, A, Zatout, O, Zeino, S, Zeitouni, M, Zemirli, N, Zerah, L, Zia, O, Ziol, M, Zolario, O, Zuber, J, Andrejak, C, Angoulvant, F, Bachelet, D, Bartoli, M, Basmaci, R, Behilill, S, Beluze, M, Benkerrou, D, Bhavsar, K, Bouadma, L, Bouchez, S, Bouscambert, M, Cervantes-Gonzalez, M, Chair, A, Coelho, A, D'Ortenzio, E, Debray, M, Deconinck, L, Deplanque, D, Descamps, D, Desvallee, M, Diallo, A, Diouf, A, Dorival, C, Dubos, F, Duval, X, Elharrar, B, Eloy, P, Enouf, V, Esperou, H, Esposito-Farese, M, Devouge, E, Gault, N, Gaymard, A, Ghosn, J, Gigante, T, Gilg, M, Guedj, J, Hoctin, A, Hoffmann, I, Houas, I, Hulot, J, Jaafoura, S, Kaguelidou, F, Kali, S, Khalil, A, Khan, C, Laouenan, C, Laribi, S, Le, M, Le Hingrat, Q, Le Mestre, S, Le Nagard, H, Lescure, F, Levy, Y, Lingas, G, Lucet, J, Malvy, D, Mambert, M, Meziane, A, Mouquet, H, Mullaert, J, Neant, N, Nguyen, D, Noret, M, Nseir, S, Papadopoulos, A, Paul, C, Peiffer-Smadja, N, Perpoint, T, Petrov-Sanchez, V, Peytavin, G, Pham, H, Picone, O, Puechal, O, Rabaud, C, Rosa-Calatrava, M, Rossignol, B, Rossignol, P, Roy, C, Schneider, M, Su, R, Tardivon, C, Tellier, M, Teoule, F, Terrier, O, Timsit, J, Tual, C, Van Der Werf, S, Vanel, N, Veislinger, A, Visseaux, B, Wiedemann, A, Yazdanpanah, Y, Alavoine, L, Behillil, S, Burdet, C, Charpentier, C, Dechanet, A, Ecobichon, J, Frezouls, W, Houhou, N, Lehacaut, J, Letrou, S, Lina, B, Manchon, P, Nouroudine, M, Piquard, V, Quintin, C, Thy, M, Vignali, V, Chahine, A, Waucquier, N, Migaud, M, Djossou, F, Mergeay-Fabre, M, Lucarelli, A, Demar, M, Bruneau, L, Gerardin, P, Maillot, A, Payet, C, Laviolle, B, Laine, F, Paris, C, Desille-Dugast, M, Fouchard, J, Pistone, T, Perreau, P, Gissot, V, Goas, C, Montagne, S, Richard, L, Chirouze, C, Bouiller, K, Desmarets, M, Meunier, A, Bourgeon, M, Lefevre, B, Jeulin, H, Legrand, K, Lomazzi, S, Tardy, B, Gagneux-Brunon, A, Bertholon, F, Botelho-Nevers, E, Christelle, K, Nicolas, L, Roufai, L, Amat, K, Couffin-Cadiergues, S, Hendou, S, Foti, G, Bellani, G, Citerio, G, Contro, E, Pesci, A, Valsecchi, M, Cazzaniga, M, Abad, J, Accordino, G, Achille, C, Aguilera-Albesa, S, Aguilo-Cucurull, A, Ozkan, E, Albisures, J, Aldave, J, Ramos, M, Khan, T, Aliberti, A, Nadji, S, Alkan, G, Alkhater, S, Allardet-Servent, J, Alshahrani, M, Alsina, L, Amoura, Z, Antoli, A, Arrestier, R, Aubart, M, Auguet, T, Avramenko, I, Azot, A, Bahram, S, Bajolle, F, Baldanti, F, Baldolli, A, Ballester, M, Barrou, B, Basso, S, Bayhan, G, Bezrodnik, L, Bilbao, A, Blanchard-Rohner, G, Blanco, I, Blandinieres, A, Blazquez-Gamero, D, Bloomfield, M, Bolivar-Prados, M, Borghesi, A, Borie, R, Botdhlo-Nevers, E, Bousquet, A, Boutolleau, D, Bouvattier, C, Boyarchuk, O, Bravais, J, Briones, M, Brunner, M, Bruno, R, Bueno, M, Bukhari, H, Bustamante, J, Agra, J, Capra, R, Carapito, R, Carrabba, M, Casasnovas, C, Caseris, M, Cassaniti, I, Castelle, M, Castelli, F, de Vera, M, Castro, M, Catherinot, E, Celik, J, Ceschi, A, Chalumeau, M, Charbit, B, Cheng, M, Clave, P, Clotet, B, Codina, A, Comoli, P, Corsico, A, Sozeri, B, Coskuner, T, Cvetkovski, A, Cyrus, C, Dalmau, D, Danion, F, Darley, D, Das, V, Dauby, N, Dauger, S, De Munter, P, de Pontual, L, Dehban, A, Delplancq, G, Desguerre, I, Di Sabatino, A, Diehl, J, Dobbelaere, S, Dominguez-Garrido, E, Dubost, C, Ekwall, O, Bozdemir, S, Elnagdy, M, Emiroglu, M, Endo, A, Erdeniz, E, Aytekin, S, Lasa, M, Euvrard, R, Fabio, G, Faivre, L, Falck, A, Faure, M, Arquero, M, Ferrer, R, Ferreres, J, Francois, B, Fumado, V, Fung, K, Fusco, F, Gagro, A, Solis, B, Garcon, P, Gaussem, P, Gayretli, Z, Gil-Herrera, J, Gilardin, L, Gatineau, A, Girona-Alarcon, M, Godinez, K, Goffard, J, Gonzales, N, Gonzalez-Granado, L, Gonzalez-Montelongo, R, Guerder, A, Gulhan, B, Gumucio, V, Hanitsch, L, Gunst, J, Hadjadj, J, Hariyan, T, Heppekcan, D, Hernandez-Brito, E, Ho, P, Holanda-Pena, M, Horcajada, J, Hraiech, S, Humbert, L, Hung, I, Iglesias, A, Inigo-Campos, A, Jamme, M, Arranz, M, Jimeno, M, Jordan, I, Yuksek, S, Kara, Y, Karahan, A, Yasar, K, Kasapcopur, O, Kashimada, K, Demirkol, Y, Kido, Y, Kizil, C, Kilic, A, Klocperk, A, Koutsoukou, A, Krol, Z, Ksouri, H, Kuentz, P, Kwan, A, Kwan, Y, Kwok, J, Lagier, J, Lam, D, Lampropoulou, V, Le Bourgeois, F, Leo, Y, Leung, D, Levin, M, Levy, M, Levy, R, Li, Z, Lilleri, D, Lima, E, Linglart, A, Lopez-Collazo, E, Lorenzo-Salazar, J, Louapre, C, Lubetzki, C, Lung, K, Luyt, C, Lye, D, Magnone, C, Marchioni, E, Marioli, C, Marjani, M, Marques, L, Pereira, J, Pueyo, D, Marzana, I, Mata-Martinez, C, Mathian, A, Matos, L, Matthews, G, Mayaux, J, McLaughlin-Garcia, R, Meersseman, P, Mege, J, Mekontso-Dessap, A, Melki, I, Meloni, F, Meritet, J, Merlani, P, Akcan, O, Mezidi, M, Millereux, M, Million, M, Mirault, T, Mircher, C, Mirsaeidi, M, Mizoguchi, Y, Modi, B, Mojoli, F, Moncomble, E, Melian, A, Martinez, A, Morandeira, F, Mordacq, C, Munoz-Barrera, A, Nafati, C, Nagashima, S, Nakagama, Y, Neven, B, Neves, J, Ng, Y, Nielly, H, Medina, Y, Cuadros, E, Ocejo-Vinyals, J, Okamoto, K, Oualha, M, Ouedrani, A, Ozcelik, T, Ozkaya-Parlakay, A, Pagani, M, Papadaki, M, Parola, P, Pascreau, T, Paul, S, Paz-Artal, E, Pedraza, S, Pellecer, N, Pellegrini, S, Perez-Fernandez, X, Philippe, A, Philippot, Q, Picod, A, Piralla, A, Ploin, D, Poissy, J, Poncelet, G, Poulakou, G, Pouletty, M, Pourshahnazari, P, Qiu-Chen, J, Quentric, P, Rambaud, T, Raoult, D, Raoult, V, Rebillat, A, Redin, C, Resmini, L, Ricart, P, Richard, J, Rigo-Bonnin, R, Rivet, N, Rocamora-Blanch, G, Rodero, M, Rodrigo, C, Rodriguez, L, 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E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozcelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. 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P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.
- Abstract
Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
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- 2023
3. Wild plants in hedgerows and weeds in crop fields are important floral resources for wild flower-visiting insects, independently of the presence of intercrops
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Aviron, S., primary, Berry, T., additional, Leroy, D., additional, Savary, G., additional, and Alignier, A., additional
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- 2023
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4. Single-cell RNA-seq characterization of lung fibrosis resolution reveals a delayed capillary endothelial signature associated with alveolar regeneration in aged mice
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Truchi, M., primary, Savary, G., additional, Lebrigand, K., additional, Baeri, A., additional, Girard-Riboulleau, C., additional, Magnone, V., additional, Leroy, S., additional, Hofman, V., additional, Hofman, P., additional, Barbry, P., additional, Bellusci, S., additional, Cauffiez, C., additional, Vassaux, G., additional, Pottier, N., additional, and Mari, B., additional
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- 2023
- Full Text
- View/download PDF
5. Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
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Fronczek, J, Polok, K, de Lange, D, Jung, C, Beil, M, Rhodes, A, Fjolner, J, Gorka, J, Andersen, F, Artigas, A, Cecconi, M, Christensen, S, Joannidis, M, Leaver, S, Marsh, B, Morandi, A, Moreno, R, Oeyen, S, Agvald-Ohman, C, Bollen Pinto, B, Schefold, J, Valentin, A, Walther, S, Watson, X, Zafeiridis, T, Sviri, S, van Heerden, P, Flaatten, H, Guidet, B, Szczeklik, W, Schmutz, R, Wimmer, F, Eller, P, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Biskup, E, Piza, P, Taliadoros, I, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, 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W., Jung C., Beil M., Rhodes A., Fjolner J., Gorka J., Andersen F. H., Artigas A., Cecconi M., Christensen S., Joannidis M., Leaver S., Marsh B., Morandi A., Moreno R., Oeyen S., Agvald-Ohman C., Bollen Pinto B., Schefold J. C., Valentin A., Walther S., Watson X., Zafeiridis T., Sviri S., van Heerden P. V., Flaatten H., Guidet B., Szczeklik W., Schmutz R., Wimmer F., Eller P., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak-Kozka I., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros N., Barros I., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Mendoza J. A. B., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L. E. M., Jansen T., Nooteboom F., van der Voort P. H. J., de Lange D., Dieperink W., de Waard M. C., de Smet A. G. E., Bormans L., Dormans T., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Williams P., Elloway E., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Helbok R., Nollet J., de Neve N., Mikacic M., Bastiansen A., Husted A., Dahle B. E. S., Cramer C., Orsnes D., Thomsen J. E., Pedersen J. J., Enevoldsen M. H., Elkmann T., Kubisz-Pudelko A., Collins A., Hart C., Randell G., Filipe H., Welters I. D., Evans J., Lord J., Jones J., Ball J., North J., Salaunkey K., De Gordoa L. O. -R., Bell L., Vizcaychipi M., Mupudzi M., Lea-Hagerty M., Spivey M., Love N., White N., Morgan P., Wakefield P., Savine R., Jacob R., Innes R., Rose S., Mane T., Ogbeide V., Baird Y., Romen A., Galbois A., Vinsonneau C., Thevenin D., Guerot E., Savary G., Chagnon J. L., Rigaud J. P., Quenot J. P., Castaneray J., Rosman J., Maizel J., Tiercelet K., Hovaere M. M., Messika M., Djibre M., Rolin N., Burtin P., Garcon P., Nseir S., Valette X., Horacek M., Bruno R. R., Allgauer S., Dubler S., Schering S., Koutsikou A., Vakalos A., Raitsiou B., Flioni E. N., Neou E., Papathanakos G., Koutsodimitropoulos I., Aikaterini K., Rovina N., Kourelea S., Polychronis T., Zidianakis V., Konstantinia V., Read C., Martin-Loeches I., Cracchiolo A. N., Morigi A., Brusa S., Elhadi A., Tarek A., Khaled A., Ahmed H., Belkhair W. A., Cornet A. D., Gommers D., van Boven E., Haringman J., Haas L., van den Berg L., Hoiting O., de Jager P., Gerritsen R. T., Breidablik A., Slapgard A., Rime A. K., Jannestad B., Sjoboe B., Rice E., Jensen J. P., Langorgen J., Toien K., Strand K., Biernacka A., Kluzik A., Kudlinski B., Hymczak H., Solek-Pastuszka J., Zorska J., Krzych L. J., Lipinska-Gediga M., Pietruszko M., Kozera N., Sendur P., Zatorski P., Galkin P., Kosciuczuk U., Gola W., Pinto A. F., Santos A. R., Ferreira I. A., Blanco J. B., Carvalho J. T., Maia J., Candeias N., Lores A., Cilloniz C., Perez-Torres D., Maseda E., Prol-Silva E., Eixarch G., Goma G., Velasco G. N., Villamayor M. I., Fernandez N. L., Cubero P. J., Tomasa T., Sjoqvist A., Schioler F., Westberg H., Thiringer K. K., Boroli F., Eckert P., Yildiz I., Yovenko I., Fronczek, J, Polok, K, de Lange, D, Jung, C, Beil, M, Rhodes, A, Fjolner, J, Gorka, J, Andersen, F, Artigas, A, Cecconi, M, Christensen, S, Joannidis, M, Leaver, S, Marsh, B, Morandi, A, Moreno, R, Oeyen, S, Agvald-Ohman, C, Bollen Pinto, B, Schefold, J, Valentin, A, Walther, S, Watson, X, Zafeiridis, T, Sviri, S, van Heerden, P, Flaatten, H, Guidet, B, Szczeklik, W, Schmutz, R, Wimmer, F, Eller, P, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Biskup, E, Piza, P, Taliadoros, I, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Gupta, M, Gurjar, M, Maji, I, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak-Kozka, I, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, N, Barros, I, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Rodriguez, E, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Mendoza, J, Lopez-Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, van Dijk, I, van Lelyveld-Haas, L, Jansen, T, Nooteboom, F, van der Voort, P, Dieperink, W, de Waard, M, de Smet, A, Bormans, L, Dormans, T, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Williams, P, Elloway, E, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Nalapko, Y, Helbok, R, Nollet, J, de Neve, N, Mikacic, M, Bastiansen, A, Husted, A, Dahle, B, Cramer, C, Orsnes, D, Thomsen, J, Pedersen, J, Enevoldsen, M, Elkmann, T, Kubisz-Pudelko, A, Collins, A, Hart, C, Randell, G, Filipe, H, Welters, I, Evans, J, Lord, J, Jones, J, Ball, J, North, J, Salaunkey, K, De Gordoa, L, Bell, L, Vizcaychipi, M, Mupudzi, M, Lea-Hagerty, M, Spivey, M, Love, N, White, N, Morgan, P, Wakefield, P, Savine, R, Jacob, R, Innes, R, Rose, S, Mane, T, Ogbeide, V, Baird, Y, Romen, A, Galbois, A, Vinsonneau, C, Thevenin, D, Guerot, E, Savary, G, Chagnon, J, Rigaud, J, Quenot, J, Castaneray, J, Rosman, J, Maizel, J, Tiercelet, K, Hovaere, M, Messika, M, Djibre, M, Rolin, N, Burtin, P, Garcon, P, Nseir, S, Valette, X, Horacek, M, Bruno, R, Allgauer, S, Dubler, S, Schering, S, Koutsikou, A, Vakalos, A, Raitsiou, B, Flioni, E, Neou, E, Papathanakos, G, Koutsodimitropoulos, I, Aikaterini, K, Rovina, N, Kourelea, S, Polychronis, T, Zidianakis, V, Konstantinia, V, Read, C, Martin-Loeches, I, Cracchiolo, A, Morigi, A, Brusa, S, Elhadi, A, Tarek, A, Khaled, A, Ahmed, H, Belkhair, W, Cornet, A, Gommers, D, van Boven, E, Haringman, J, Haas, L, van den Berg, L, Hoiting, O, de Jager, P, Gerritsen, R, Breidablik, A, Slapgard, A, Rime, A, Jannestad, B, Sjoboe, B, Rice, E, Jensen, J, Langorgen, J, Toien, K, Strand, K, Biernacka, A, Kluzik, A, Kudlinski, B, Hymczak, H, Solek-Pastuszka, J, Zorska, J, Krzych, L, Lipinska-Gediga, M, Pietruszko, M, Kozera, N, Sendur, P, Zatorski, P, Galkin, P, Kosciuczuk, U, Gola, W, Pinto, A, Santos, A, Ferreira, I, Blanco, J, Carvalho, J, Maia, J, Candeias, N, Lores, A, Cilloniz, C, Perez-Torres, D, Maseda, E, Prol-Silva, E, Eixarch, G, Goma, G, Velasco, G, Villamayor, M, Fernandez, N, Cubero, P, Tomasa, T, Sjoqvist, A, Schioler, F, Westberg, H, Boroli, F, Eckert, P, Yildiz, I, Yovenko, I, Fronczek J., Polok K., de Lange D. W., Jung C., Beil M., Rhodes A., Fjolner J., Gorka J., Andersen F. H., Artigas A., Cecconi M., Christensen S., Joannidis M., Leaver S., Marsh B., Morandi A., Moreno R., Oeyen S., Agvald-Ohman C., Bollen Pinto B., Schefold J. C., Valentin A., Walther S., Watson X., Zafeiridis T., Sviri S., van Heerden P. V., Flaatten H., Guidet B., Szczeklik W., Schmutz R., Wimmer F., Eller P., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak-Kozka I., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros N., Barros I., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Mendoza J. A. B., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L. E. M., Jansen T., Nooteboom F., van der Voort P. H. J., de Lange D., Dieperink W., de Waard M. C., de Smet A. G. E., Bormans L., Dormans T., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Williams P., Elloway E., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Helbok R., Nollet J., de Neve N., Mikacic M., Bastiansen A., Husted A., Dahle B. E. S., Cramer C., Orsnes D., Thomsen J. E., Pedersen J. J., Enevoldsen M. H., Elkmann T., Kubisz-Pudelko A., Collins A., Hart C., Randell G., Filipe H., Welters I. D., Evans J., Lord J., Jones J., Ball J., North J., Salaunkey K., De Gordoa L. O. -R., Bell L., Vizcaychipi M., Mupudzi M., Lea-Hagerty M., Spivey M., Love N., White N., Morgan P., Wakefield P., Savine R., Jacob R., Innes R., Rose S., Mane T., Ogbeide V., Baird Y., Romen A., Galbois A., Vinsonneau C., Thevenin D., Guerot E., Savary G., Chagnon J. L., Rigaud J. P., Quenot J. P., Castaneray J., Rosman J., Maizel J., Tiercelet K., Hovaere M. M., Messika M., Djibre M., Rolin N., Burtin P., Garcon P., Nseir S., Valette X., Horacek M., Bruno R. R., Allgauer S., Dubler S., Schering S., Koutsikou A., Vakalos A., Raitsiou B., Flioni E. N., Neou E., Papathanakos G., Koutsodimitropoulos I., Aikaterini K., Rovina N., Kourelea S., Polychronis T., Zidianakis V., Konstantinia V., Read C., Martin-Loeches I., Cracchiolo A. N., Morigi A., Brusa S., Elhadi A., Tarek A., Khaled A., Ahmed H., Belkhair W. A., Cornet A. D., Gommers D., van Boven E., Haringman J., Haas L., van den Berg L., Hoiting O., de Jager P., Gerritsen R. T., Breidablik A., Slapgard A., Rime A. K., Jannestad B., Sjoboe B., Rice E., Jensen J. P., Langorgen J., Toien K., Strand K., Biernacka A., Kluzik A., Kudlinski B., Hymczak H., Solek-Pastuszka J., Zorska J., Krzych L. J., Lipinska-Gediga M., Pietruszko M., Kozera N., Sendur P., Zatorski P., Galkin P., Kosciuczuk U., Gola W., Pinto A. F., Santos A. R., Ferreira I. A., Blanco J. B., Carvalho J. T., Maia J., Candeias N., Lores A., Cilloniz C., Perez-Torres D., Maseda E., Prol-Silva E., Eixarch G., Goma G., Velasco G. N., Villamayor M. I., Fernandez N. L., Cubero P. J., Tomasa T., Sjoqvist A., Schioler F., Westberg H., Thiringer K. K., Boroli F., Eckert P., Yildiz I., and Yovenko I.
- Abstract
Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). Conclusion: Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)
- Published
- 2021
6. Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
- Author
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Fronczek, Jakub, Polok, Kamil, de Lange, Dylan W., Jung, Christian, Beil, Michael, Rhodes, Andrew, Fjølner, Jesper, Górka, Jacek, Andersen, Finn H., Artigas, Antonio, Cecconi, Maurizio, Christensen, Steffen, Joannidis, Michael, Leaver, Susannah, Marsh, Brian, Morandi, Alessandro, Moreno, Rui, Oeyen, Sandra, Agvald-Öhman, Christina, Bollen Pinto, Bernardo, Schefold, Joerg C., Valentin, Andreas, Walther, Sten, Watson, Ximena, Zafeiridis, Tilemachos, Sviri, Sigal, van Heerden, Peter Vernon, Flaatten, Hans, Guidet, Bertrand, Szczeklik, Wojciech, Schmutz, R., Wimmer, F., Eller, P., Joannidis, M., De Buysscher, P., De Neve, N., Oeyen, S., Swinnen, W., Bollen Pinto, B., Abraham, P., Hergafi, L., Schefold, J. C., Biskup, E., Piza, P., Taliadoros, I., Fjølner, J., Dey, N., Sølling, C., Rasmussen, B. S., Christensen, S., Forceville, X., Besch, G., Mentec, H., Michel, P., Mateu, P., Vettoretti, L., Bourenne, J., Marin, N., Guillot, M., Aissaoui, N., Goulenok, C., Thieulot-Rolin, N., Messika, J., Lamhaut, L., Guidet, B., Charron, C., Lauten, A., Sacher, A. L., Brenner, T., Franz, M., Bloos, F., Ebelt, H., Schaller, S. J., Fuest, K., Rabe, C., Dieck, T., Steiner, S., Graf, T., Nia, A. M., Jung, C., Janosi, R. A., Meybohm, P., Simon, P., Utzolino, S., Rahmel, T., Barth, E., Schuster, M., Aidoni, Z., Aloizos, S., Tasioudis, P., Lampiri, K., Zisopoulou, V., Ravani, I., Pagaki, E., Antoniou, A., Katsoulas, T. A., Kounougeri, A., Marinakis, G., Tsimpoukas, F., Spyropoulou, A., Zygoulis, P., Kyparissi, A., Gupta, M., Gurjar, M., Maji, I. M., Hayes, I., Marsh, B., Kelly, Y., Westbrook, A., Fitzpatrick, G., Maheshwari, D., Motherway, C., Negri, G., Spadaro, S., Nattino, G., Pedeferri, M., Boscolo, A., Rossi, S., Calicchio, G., Cubattoli, L., Di Lascio, G., Barbagallo, M., Berruto, F., Codazzi, D., Bottazzi, A., Fumagalli, P., Negro, G., Lupi, G., Savelli, F., Vulcano, G. A., Fumagalli, R., Marudi, A., Lefons, U., Lembo, R., Babini, M., Paggioro, A., Parrini, V., Zaccaria, M., Clementi, S., Gigliuto, C., Facondini, F., Pastorini, S., Munaron, S., Calamai, I., Bocchi, A., Adorni, A., Bocci, M. G., Cortegiani, A., Casalicchio, T., Mellea, S., Graziani, E., Barattini, M., Brizio, E., Rossi, M., Hahn, M., Flaatten, H., Kemmerer, N., Strietzel, H. F., Dybwik, K., Legernaes, T., Klepstad, P., Olaussen, E. B., Olsen, K. I., Brresen, O. M., Bjorsvik, G., Andersen, F. H., Maini, S., Fehrle, L., Czuczwar, M., Krawczyk, P., Ziętkiewicz, M., Nowak, Ł. R., Kotfis, K., Cwyl, K., Gajdosz, R., Biernawska, J., Bohatyrewicz, R., Gawda, R., Grudzień, P., Nasiłowski, P., Popek, N., Cyrankiewicz, W., Wawrzyniak, K., Wnuk, M., Maciejewski, D., Studzińska, D., Żukowski, M., Bernas, S., Piechota, M., Szczeklik, W., Nowak-Kózka, I., Fronczek, J., Serwa, M., Machała, W., Stefaniak, J., Wujtewicz, M., Maciejewski, P., Szymkowiak, M., Adamik, B., Polok, K., Górka, J., Catorze, N., Branco, M. C., Barros, N., Barros, I., Krystopchuk, A., Honrado, T., Sousa, C., Munoz, F., Rebelo, M., Gomes, R., Nunes, J., Dias, C., Fernandes, A. M., Petrisor, C., Constantin, B., Belskiy, V., Boskholov, B., Rodriguez, E., Aguilar, G., Masdeu, G., Jaimes, M. I., Mira, A. P., Bodi, M. A., Mendoza, J. A. B., López-Cuenca, S., Guzman, M. H., Rico-Feijoo, J., Ibarz, M., Alvarez, J. Trenado, Kawati, R., Sivik, J., Nauska, J., Smole, D., Parenmark, F., Lyrén, J., Rockstroh, K., Rydén, S., Spångfors, M., Strinnholm, M., Walther, S., De Geer, L., Nordlund, P., Pålsson, S., Zetterquist, H., Nilsson, A., Thiringer, K., Jungner, M., Bark, B., Nordling, B., Sköld, H., Brorsson, C., Persson, S., Bergström, A., Berkius, J., Holmström, J., van Dijk, I., van Lelyveld-Haas, L. E. M., Jansen, T., Nooteboom, F., van der Voort, P. H. J., de Lange, D., Dieperink, W., de Waard, M. C., de Smet, A. G. E., Bormans, L., Dormans, T., Dempsey, G., Mathew, S. J., Raj, A. S., Grecu, I., Cupitt, J., Lawton, T., Clark, R., Popescu, M., Spittle, N., Faulkner, M., Cowton, A., Williams, P., Elloway, E., Reay, M., Chukkambotla, S., Kumar, R., Al-Subaie, N., Kent, L., Tamm, T., Kajtor, I., Burns, K., Pugh, R., Ostermann, M., Kam, E., Bowyer, H., Smith, N., Templeton, M., Henning, J., Goffin, K., Kapoor, R., Laha, S., Chilton, P., Khaliq, W., Crayford, A., Coetzee, S., Tait, M., Stoker, W., Gimenez, M., Pope, A., Camsooksai, J., Pogson, D., Quigley, K., Ritzema, J., Hormis, A., Boulanger, C., Balasubramaniam, M., Vamplew, L., Burt, K., Martin, D., Craig, J., Prowle, J., Doyle, N., Shelton, J., Scott, C., Donnison, P., Shelton, S., Frey, C., Ryan, C., Spray, D., Barnes, V., Barnes, K., Ridgway, S., Saha, R., Clark, T., Wood, J., Bolger, C., Bassford, C., Lewandowski, J., Zhao, X., Humphreys, S., Dowling, S., Richardson, N., Burtenshaw, A., Stevenson, C., Wilcock, D., Nalapko, Y., Helbok, R., Nollet, J., de Neve, N., Mikačić, M., Bastiansen, A., Husted, A., Dahle, B. E. S., Cramer, C., Ørsnes, D., Thomsen, J. Edelberg, Pedersen, J. J., Enevoldsen, M. Hummelmose, Elkmann, T., Kubisz-Pudelko, A., Collins, A., Hart, C., Randell, G., Filipe, H., Welters, I. D., Evans, J., Lord, J., Jones, J., Ball, J., North, J., Salaunkey, K., De Gordoa, L. Ortiz-Ruiz, Bell, L., Vizcaychipi, M., Mupudzi, M., Lea-Hagerty, M., Spivey, M., Love, N., White, N., Morgan, P., Wakefield, P., Savine, R., Jacob, R., Innes, R., Rose, S., Leaver, S., Mane, T., Ogbeide, V., Baird, Y., Romen, A., Galbois, A., Vinsonneau, C., Thevenin, D., Guerot, E., Savary, G., Chagnon, J. L., Rigaud, J. P., Quenot, J. P., Castaneray, J., Rosman, J., Maizel, J., Tiercelet, K., Hovaere, M. M., Messika, M., Djibré, M., Rolin, N., Burtin, P., Garcon, P., Nseir, S., Valette, X., Horacek, M., Bruno, R. Romano, Allgäuer, S., Dubler, S., Schering, S., Koutsikou, A., Vakalos, A., Raitsiou, B., Flioni, E. N., Neou, E., Papathanakos, G., Koutsodimitropoulos, I., Aikaterini, K., Rovina, N., Kourelea, S., Polychronis, T., Zidianakis, V., Konstantinia, V., Read, C., Martin-Loeches, I., Cracchiolo, A. Neville, Morigi, A., Brusa, S., Elhadi, A., Tarek, A., Khaled, A., Ahmed, H., Belkhair, W. Ali, Cornet, A. D., Gommers, D., van Boven, E., Haringman, J., Haas, L., van den Berg, L., Hoiting, O., de Jager, P., Gerritsen, R. T., Breidablik, A., Slapgard, A., Rime, A. K., Jannestad, B., Sjøbøe, B., Rice, E., Jensen, J. P., Langørgen, J., Tøien, K., Strand, K., Biernacka, A., Kluzik, A., Kudlinski, B., Hymczak, H., Solek-Pastuszka, J., Zorska, J., Krzych, Ł. J., Zukowski, M., Lipińska-Gediga, M., Pietruszko, M., Kozera, N., Sendur, P., Zatorski, P., Galkin, P., Kościuczuk, U., Gola, W., Pinto, A. F., Santos, A. R., Ferreira, I. A., Blanco, J. B., Carvalho, J. T., Maia, J., Candeias, N., Lores, A., Cilloniz, C., Perez-Torres, D., Maseda, E., Prol-Silva, E., Eixarch, G., Gomà, G., Velasco, G. Navarro, Jaimes, M. Irazábal, Villamayor, M. Ibarz, Fernández, N. Llamas, Cubero, P. Jimeno, Tomasa, T., Sjöqvist, A., Schiöler, F., Westberg, H., Thiringer, K. Kleiven, Boroli, F., Eckert, P., Yıldız, I., Yovenko, I., for the VIP1, [missing], VIP2 study group, [missing], Fronczek, Jakub, Polok, Kamil, de Lange, Dylan W, Jung, Christian, Beil, Michael, Rhodes, Andrew, Fjølner, Jesper, Górka, Jacek, Andersen, Finn H, Artigas, Antonio, Cecconi, Maurizio, Christensen, Steffen, Joannidis, Michael, Leaver, Susannah, Marsh, Brian, Morandi, Alessandro, Moreno, Rui, Oeyen, Sandra, Agvald-Öhman, Christina, Bollen Pinto, Bernardo, Schefold, Joerg C, Valentin, Andrea, Walther, Sten, Watson, Ximena, Zafeiridis, Tilemacho, Sviri, Sigal, van Heerden, Peter Vernon, Flaatten, Han, Guidet, Bertrand, Szczeklik, Wojciech, R Schmutz, F Wimmer, P Eller, M Joannidis, P De Buysscher, N De Neve, S Oeyen, W Swinnen, B Bollen Pinto, P Abraham, L Hergafi, J C Schefold, E Biskup, P Piza, I Taliadoros, J Fjølner, N Dey, C Sølling, B S Rasmussen, S Christensen, X Forceville, G Besch, H Mentec, P Michel, P Mateu, P Michel, L Vettoretti, J Bourenne, N Marin, M Guillot, N Aissaoui, C Goulenok, N Thieulot-Rolin, J Messika, L Lamhaut, B Guidet, C Charron, A Lauten, A L Sacher, T Brenner, M Franz, F Bloos, H Ebelt, S J Schaller, K Fuest, C Rabe, T Dieck, S Steiner, T Graf, A M Nia, C Jung, R A Janosi, P Meybohm, P Simon, S Utzolino, T Rahmel, E Barth, C Jung, M Schuster, Z Aidoni, S Aloizos, P Tasioudis, K Lampiri, V Zisopoulou, I Ravani, E Pagaki, A Antoniou, T A Katsoulas, A Kounougeri, G Marinakis, F Tsimpoukas, A Spyropoulou, P Zygoulis, A Kyparissi, M Gupta, M Gurjar, I M Maji, I Hayes, B Marsh, Y Kelly, A Westbrook, G Fitzpatrick, D Maheshwari, C Motherway, G Negri, S Spadaro, G Nattino, M Pedeferri, A Boscolo, S Rossi, G Calicchio, L Cubattoli, G Di Lascio, M Barbagallo, F Berruto, D Codazzi, A Bottazzi, P Fumagalli, G Negro, G Lupi, F Savelli, G A Vulcano, R Fumagalli, A Marudi, U Lefons, R Lembo, M Babini, A Paggioro, V Parrini, M Zaccaria, S Clementi, C Gigliuto, F Facondini, S Pastorini, S Munaron, I Calamai, A Bocchi, A Adorni, M G Bocci, A Cortegiani, T Casalicchio, S Mellea, E Graziani, M Barattini, E Brizio, M Rossi, M Hahn, H Flaatten, N Kemmerer, H F Strietzel, K Dybwik, T Legernaes, P Klepstad, E B Olaussen, K I Olsen, O M Brresen, G Bjorsvik, F H Andersen, S Maini, L Fehrle, M Czuczwar, P Krawczyk, M Ziętkiewicz, Ł R Nowak, K Kotfis, K Cwyl, R Gajdosz, J Biernawska, R Bohatyrewicz, R Gawda, P Grudzień, P Nasiłowski, N Popek, W Cyrankiewicz, K Wawrzyniak, M Wnuk, D Maciejewski, D Studzińska, M Żukowski, S Bernas, M Piechota, W Szczeklik, I Nowak-Kózka, J Fronczek, M Serwa, W Machała, J Stefaniak, M Wujtewicz, P Maciejewski, M Szymkowiak, B Adamik, K Polok, J Górka, N Catorze, M C Branco, N Barros, I Barros, A Krystopchuk, T Honrado, C Sousa, F Munoz, M Rebelo, R Gomes, J Nunes, C Dias, A M Fernandes, C Petrisor, B Constantin, V Belskiy, B Boskholov, E Rodriguez, G Aguilar, G Masdeu, M I Jaimes, A P Mira, M A Bodi, J A B Mendoza, S López-Cuenca, M H Guzman, J Rico-Feijoo, M Ibarz, J Trenado Alvarez, R Kawati, J Sivik, J Nauska, D Smole, F Parenmark, J Lyrén, K Rockstroh, S Rydén, M Spångfors, M Strinnholm, S Walther, L De Geer, P Nordlund, S Pålsson, H Zetterquist, A Nilsson, K Thiringer, M Jungner, B Bark, B Nordling, H Sköld, C Brorsson, S Persson, A Bergström, J Berkius, J Holmström, I van Dijk, L E M van Lelyveld-Haas, T Jansen, F Nooteboom, P H J van der Voort, D de Lange, W Dieperink, M C de Waard, A G E de Smet, L Bormans, T Dormans, G Dempsey, S J Mathew, A S Raj, I Grecu, J Cupitt, T Lawton, R Clark, M Popescu, N Spittle, M Faulkner, A Cowton, P Williams, E Elloway, M Reay, S Chukkambotla, R Kumar, N Al-Subaie, L Kent, T Tamm, I Kajtor, K Burns, R Pugh, M Ostermann, E Kam, H Bowyer, N Smith, M Templeton, J Henning, K Goffin, R Kapoor, S Laha, P Chilton, W Khaliq, A Crayford, S Coetzee, M Tait, W Stoker, M Gimenez, A Pope, J Camsooksai, D Pogson, K Quigley, J Ritzema, A Hormis, C Boulanger, M Balasubramaniam, L Vamplew, K Burt, D Martin, I Grecu, J Craig, J Prowle, N Doyle, J Shelton, C Scott, P Donnison, S Shelton, C Frey, C Ryan, D Spray, C Ryan, V Barnes, K Barnes, S Ridgway, R Saha, L Kent, T Clark, J Wood, C Bolger, C Bassford, A Cowton, J Lewandowski, X Zhao, S Humphreys, S Dowling, N Richardson, A Burtenshaw, C Stevenson, D Wilcock, Y Nalapko, M Joannidis, P Eller, R Helbok, R Schmutz, J Nollet, N de Neve, P De Buysscher, S Oeyen, W Swinnen, M Mikačić, A Bastiansen, A Husted, B E S Dahle, C Cramer, C Sølling, D Ørsnes, J Edelberg Thomsen, J J Pedersen, M Hummelmose Enevoldsen, T Elkmann, A Kubisz-Pudelko, A Pope, A Collins, A S Raj, C Boulanger, C Frey, C Hart, C Bolger, D Spray, G Randell, H Filipe, I D Welters, I Grecu, J Evans, J Cupitt, J Lord, J Henning, J Jones, J Ball, J North, K Salaunkey, L Ortiz-Ruiz De Gordoa, L Bell, M Balasubramaniam, M Vizcaychipi, M Faulkner, M Mupudzi, M Lea-Hagerty, M Reay, M Spivey, N Love, N Spittle, N White, P Williams, P Morgan, P Wakefield, R Savine, R Jacob, R Innes, R Kapoor, S Humphreys, S Rose, S Dowling, S Leaver, T Mane, T Lawton, V Ogbeide, W Khaliq, Y Baird, A Romen, A Galbois, B Guidet, C Vinsonneau, C Charron, D Thevenin, E Guerot, G Besch, G Savary, H Mentec, J L Chagnon, J P Rigaud, J P Quenot, J Castaneray, J Rosman, J Maizel, K Tiercelet, L Vettoretti, M M Hovaere, M Messika, M Djibré, N Rolin, P Burtin, P Garcon, S Nseir, X Valette, C Rabe, E Barth, H Ebelt, K Fuest, M Franz, M Horacek, M Schuster, P Meybohm, R Romano Bruno, S Allgäuer, S Dubler, S J Schaller, S Schering, S Steiner, T Dieck, T Rahmel, T Graf, A Koutsikou, A Vakalos, B Raitsiou, E N Flioni, E Neou, F Tsimpoukas, G Papathanakos, G Marinakis, I Koutsodimitropoulos, K Aikaterini, N Rovina, S Kourelea, T Polychronis, V Zidianakis, V Konstantinia, Z Aidoni, B Marsh, C Motherway, C Read, I Martin-Loeches, A Neville Cracchiolo, A Morigi, I Calamai, S Brusa, A Elhadi, A Tarek, A Khaled, H Ahmed, W Ali Belkhair, A D Cornet, D Gommers, D de Lange, E van Boven, J Haringman, L Haas, L van den Berg, O Hoiting, P de Jager, R T Gerritsen, T Dormans, W Dieperink, A Breidablik, A Slapgard, A K Rime, B Jannestad, B Sjøbøe, E Rice, F H Andersen, H F Strietzel, J P Jensen, J Langørgen, K Tøien, K Strand, M Hahn, P Klepstad, A Biernacka, A Kluzik, B Kudlinski, D Maciejewski, D Studzińska, H Hymczak, J Stefaniak, J Solek-Pastuszka, J Zorska, K Cwyl, Ł J Krzych, M Zukowski, M Lipińska-Gediga, M Pietruszko, M Piechota, M Serwa, M Czuczwar, M Ziętkiewicz, N Kozera, P Nasiłowski, P Sendur, P Zatorski, P Galkin, R Gawda, U Kościuczuk, W Cyrankiewicz, W Gola, A F Pinto, A M Fernandes, A R Santos, C Sousa, I Barros, I A Ferreira, J B Blanco, J T Carvalho, J Maia, N Candeias, N Catorze, V Belskiy, A Lores, A P Mira, C Cilloniz, D Perez-Torres, E Maseda, E Rodriguez, E Prol-Silva, G Eixarch, G Gomà, G Aguilar, G Navarro Velasco, M Irazábal Jaimes, M Ibarz Villamayor, N Llamas Fernández, P Jimeno Cubero, S López-Cuenca, T Tomasa, A Sjöqvist, C Brorsson, F Schiöler, H Westberg, J Nauska, J Sivik, J Berkius, K Kleiven Thiringer, L De Geer, S Walther, F Boroli, J C Schefold, L Hergafi, P Eckert, I Yıldız, I Yovenko, Y Nalapko, R Pugh, and Critical Care
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Male ,Short term mortality ,Critical Care and Intensive Care Medicine ,Cohort Studies ,0302 clinical medicine ,kwetsbaarheid ,Medicine and Health Sciences ,80 and over ,Medicine ,610 Medicine & health ,Prospective cohort study ,Correlation of Data ,11 Medical and Health Sciences ,Aged, 80 and over ,OUTCOMES ,Intensive care units ,Frailty ,VIP1 ,Aged,  ,Medical emergencies. Critical care. Intensive care. First aid ,Scale (social sciences) ,Female ,prospectief onderzoek ,Life Sciences & Biomedicine ,CRITICALLY-ILL PATIENTS ,Study groups ,medicine.medical_specialty ,Anestesi och intensivvård ,80 jaar en ouder ,INTENSIVE-CARE ,BED AVAILABILITY ,NO ,03 medical and health sciences ,Critical Care Medicine ,Intensive care ,sterfte ,General & Internal Medicine ,Humans ,Aged ,Prospective studies ,Mortality ,In patient ,ddc:610 ,Intensive Care Units ,Logistic Models ,Prospective Studies ,Science & Technology ,Anesthesiology and Intensive Care ,business.industry ,RC86-88.9 ,Research ,030208 emergency & critical care medicine ,ADULTS ,Aged, 80 and over ,Emergency & Critical Care Medicine ,030228 respiratory system ,intensivecareafdelingen ,Critical illness ,Emergency medicine ,VIP2 study group ,  ,CRITICAL ILLNESS ,business - Abstract
Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p p Conclusion Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)
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- 2021
7. Comparison of Fractal and Conventional Topographic Analysis of Electric Discharge Machined Ceramic Surfaces
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Brown, C. A., Dauw, D. F., Savary, G., and Meguid, S. A., editor
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- 1990
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8. A review of environmental odor quantification and qualification methods : The question of objectivity in sensory analysis
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HAWKO, Charbel., VERRIELE, Marie., Hucher, N., CRUNAIRE, Sabine., LEGER, C., LOCOGE, Nadine., Savary, G., Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Nord Europe), Institut Mines-Télécom [Paris] (IMT), UNIVERSITE DU HAVRE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Atmo Normandie, Unité de Recherche en Chimie Organique et Macromoléculaire (URCOM), Université Le Havre Normandie (ULH), and Normandie Université (NU)-Normandie Université (NU)
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[SDE]Environmental Sciences ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2021
9. Effects of dietary changes on the antibacterial activity of pancreatic juice in weaned piglets
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Huguet, A., Savary, G., Bobillier, E., Lebreton, Y., and Le Huërou-Luron, I.
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- 2007
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10. Effects of level of feed intake on pancreatic exocrine secretions during the early postweaning period in piglets
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Huguet, A., Savary, G., Bobillier, E., Lebreton, Y., and Huerou-Luron, I. Le
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Swine -- Research ,Swine -- Analysis ,Pigeons -- Food and nutrition ,Zoology and wildlife conservation - Abstract
The objective of this study was to determine the influence of the level of feed intake and a 2d feed restriction period on the postweaning adaptation of pancreatic exocrine secretions. At 33 d of age, 18 piglets fitted with 2 permanents catheters (for pancreatic juice collection and reintroduction) were weaned and allocated to 1 of the following 2 dietary treatments for 5 d: restricted feed allocation (restricted) or gradually increasing feed allocation (control). Pancreatic juice was collected daily during both basal and prandial periods. The basal period was defined as the period from 1400 to 1700 h (i.e., 5 to 8 h after the morning meal), whereas the prandial period was defined as the period from 30 min before to 60 min after the morning meal (given at 0900). Digestive enzyme activities and antibacterial activity were determined. Pancreatic protein secretion was 44% less (P < 0.05) in restricted piglets than in control piglets during the basal period. Trypsin secretion was affected by feed-restriction of piglets. The meal did not affect protein and trypsin secretions in restricted piglets, whereas at d 3 postweaning, protein and trypsin secretions and trypsin specific activity in control piglets were 9-, 105-, and 25-fold greater (P < 0.001) during the first 30 min after the meal than before the meal. Lipase and amylase secretions were not affected by variations in feed intake. The secretion of antibacterial activity in restricted piglets was greater (P < 0.05) than that of control piglets only at d 5. The extended feed restriction period increased the basal secretion of antibacterial activity (P = 0.09) and postprandial secretion of amylase (P = 0.05). In conclusion, a low level of feed intake during the early postweaning period decreased pancreatic protein and trypsin secretions, whereas a 2-d feed restriction period enhanced secretions of amylase and antibacterial activity. In addition, our results indicate that during periods of dietary adaptation, such as at weaning, measurements of enzyme activities in the tissue do not accurately reflect the enzyme secretion. Key words: antibacterial activity, digestive enzyme, feed intake, pancreatic secretion, piglet, weaning
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- 2006
11. Impact of the Microstructure on Flavour Diffusion and Release in Fruit Preparations
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Savary, G., primary, Doublier, J.-L., additional, and Cayot, N., additional
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- 2008
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12. Sensory perception of textural properties of cosmetic Pickering emulsions
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Terescenco, D., primary, Hucher, N., additional, Picard, C., additional, and Savary, G., additional
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- 2020
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13. Cadmium-Induced Renal Cell Toxicity Is Associated With MicroRNA Deregulation
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Lemaire, J., primary, Van der Hauwaert, C., additional, Savary, G., additional, Dewaeles, E., additional, Perrais, M., additional, Lo Guidice, J. M., additional, Pottier, N., additional, Glowacki, F., additional, and Cauffiez, C., additional
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- 2020
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14. Le Langage des Nez® : un atout pour limiter l’incidence d’une pollution olfactive – application à la zone industrialo-portuaire du Havre
- Author
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HAWKO, C., VERRIELE, M., Hucher, N., CRUNAIRE, S., LEGER, C., Locoge, N., Savary, G., Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT), UNIVERSITE DU HAVRE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and Atmo Normandie
- Subjects
[INFO]Computer Science [cs] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
15. Evaluation of mixing and shear stresses in High Rate Algae Ponds for different paddlewheel designs
- Author
-
Rueda Villegas, Lucia, Specklin, Mathieu, Savary, G, Kohn, Yair, and Delauré, Yan
- Subjects
High Rate Algae Ponds ,HRAP ,Water quality - Abstract
Achieving appropriate hydrodynamic mixing in the design and operation of large-scale High Rate Algae Pond (HRAP) ponds can be a delicate task which depends on a number of sometimes competing factors. Dealing with living cells require knowledge of their sensitivity to external conditions (shear stress, light, CO2, etc.). For example, vertical mixing is used to control the amount of light reaching the micro-organisms but must account for the organism sensitivity to excessive light exposure. The design and operation of mixing systems must also consider potential damage due to excessive strain induced by hydrodynamic shear stresses. Too much mixing can generate cell damage due to the sensitivity of certain strains to shear stress. From an operational efficiency point of view, it is also important to minimize the energy required by the mixing system. In standard HRAP, mixing is often provided by horizontal axis paddlewheels whose primary role is to drive the pond circulation. This project aims to study the full mixing process in a conventional HRAP design with a view to determining the flow conditions needed improve the productivity of the systems. A pilot experiment was built in Arava demo-site to study the fish wastewater treatment with spirulina. Numerical simulations of the fluid flow in a small (3.5m x 1.5m x 0.2 m) and a long (16.5 m x 1.5 m x 0.2 m) HRAP taking into account the paddle wheel using the immersed boundary method implemented by Specklin et al. [1]. A Large Eddy Simulation (LES) model have been used to model turbulence, a multiphase-particle-in-cell (MPPIC) method was included to capture the interaction of flow and moving boundaries with inert particles used to simulate the micro-algae. The results highlight that mixing occurs mostly in the bends and the neighbourhood of the paddlewheel. There is little mixing in the middle of the long pond. The quality of mixing with different paddlewheel geometries is also studied. The effect of the geometry (aligned and non-aligned blades) has previously been investigated by Hreiz et al. [2]. They show that by using the aligned-blades configuration the mixing is enhanced. In this study, we focussed on two different paddlewheel geometries with aligned-blades. A methodology to evaluate the vertical mixing has been developed by computing the average absolute velocity in several transversal sections all along the pond. Also, the particle light/dark cycles have been characterised by following the particle trajectories. Particles are injected in the fluid flow to determine the amount of particles that receive enough light and those that stay in the dark zones. The shear stress in all the pond has also been computed. The results show that maximum shear stress occurs in the bends, the walls and in the neighbourhood of the paddlewheel. The different configurations of paddlewheels are evaluated in terms of their ability to provide a suitable vertical mixing with a proper amount of energy and with minimum shear stress. This study was financed by the European project SaltGae [3] whose goal is to develop a viable solution to treat saline wastewater. [1] M. Specklin, R. Connolly, B. Breen and Y. Delauré, A versatile immersed boundary method for pump design, 3rd international Rotating Equipment Conference (Dusseldorf), Germany (sept. 2016). [2] R. Hreiz, B. Sialve, J. Morchain, R. Escudié, J.-P. Steyer and P. Guiraud, Experimental and numerical investigation of hydrodynamics in raceway reactors used for algaculture, Chemical Engineering Journal, 250 (2014) 230-239. [3] SaltGae, Algae to treat saline wastewater, saltage.eu
- Published
- 2019
16. Influence of the emollient on emulsions containing lamellar liquid crystals: from molecular organization towards applicative properties
- Author
-
Terescenco, D., primary, Savary, G., additional, Picard, C., additional, Clemenceau, F., additional, Merat, E., additional, and Grisel, M., additional
- Published
- 2018
- Full Text
- View/download PDF
17. Implication de miR-21 dans les agressions rénales
- Author
-
Van Der Hauwaert, C., primary, Hennino, M.F., additional, Vandenbussche, C., additional, Dewaeles, E., additional, Gnemmi, V., additional, Savary, G., additional, Pottier, N., additional, Glowacki, F., additional, and Cauffiez, C., additional
- Published
- 2018
- Full Text
- View/download PDF
18. Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases
- Author
-
Savary, G., primary, Buscot, M., additional, Dewaeles, E., additional, Diazzi, S., additional, Nottet, N., additional, Courcot, E., additional, Fassy, J., additional, Lebrigand, K., additional, Henaoui, I. S., additional, Martis, N., additional, Van der Hauwaert, C., additional, Leroy, S., additional, Plantier, L., additional, Paquet, A., additional, Lino Cardenas, C. L., additional, Vassaux, G., additional, Crestani, B., additional, Wallaert, B., additional, Rezzonico, R., additional, Brousseau, T., additional, Glowacki, F., additional, Bellusci, S., additional, Perrais, M., additional, Broly, F., additional, Barbry, P., additional, Marquette, C. H., additional, Cauffiez, C., additional, Mari, B., additional, and Pottier, N., additional
- Published
- 2018
- Full Text
- View/download PDF
19. Hyperadrenergic Syndrome In Severe Tetanus: Extreme Rise In Catecholamines Responsive To Labetalol
- Author
-
Domenighetti, G. M., Savary, G., and Stricker, H.
- Published
- 1984
20. Organochlorine Insecticide Residues in Human Adipose Tissue of Canadians
- Author
-
Ritcey, W. R., Savary, G., and McCully, K. A.
- Published
- 1973
21. Organochlorine Insecticide Residues in Human Milk, Evaporated Milk and Some Milk Substitutes in Canada
- Author
-
Ritcey, W. R., Savary, G., and McCully, K. A.
- Published
- 1972
22. Impact de l’IMC sur le pronostic des patients admis en réanimation pour arrêt cardiaque
- Author
-
Savary, G., primary, Geri, G., additional, Legriel, S., additional, Dumas, F., additional, Merceron, S., additional, Bedos, J.P., additional, Mira, J.P., additional, Empana, J., additional, Cariou, A., additional, and Grimaldi, D., additional
- Published
- 2014
- Full Text
- View/download PDF
23. Implication du microARN miR-21 dans la progression de la maladie de Berger
- Author
-
Hennino, M.F., primary, Van Der Hauwaert, C., additional, Jomaa, Z., additional, Savary, G., additional, Buob, D., additional, Gnemmi, V., additional, Noel, C., additional, Cauffiez, C., additional, and Glowacki, F., additional
- Published
- 2014
- Full Text
- View/download PDF
24. IGA NEPHROPATHY
- Author
-
Grchevska, L., primary, Pesce, F., additional, Diciolla, M., additional, Naso, D., additional, Di Noia, T., additional, Ostuni, V. C., additional, Binetti, G., additional, Di Sciascio, E., additional, Schena, F. P., additional, Vergano, L., additional, Loiacono, E., additional, Peruzzi, L., additional, Amore, A., additional, Boido, A., additional, Mariano, F., additional, Mazzucco, G., additional, Ravera, S., additional, Cancarini, G., additional, Magistroni, R., additional, Beltrame, G., additional, Rollino, C., additional, Stratta, P., additional, Quaglia, M., additional, Bergia, R., additional, Cravero, R., additional, Cusinato, S., additional, Benozzi, L., additional, Savoldi, S., additional, Licata, C., additional, Albera, R., additional, Coppo, R., additional, Yurkevich, M., additional, Komissarov, K., additional, Pilotovich, V., additional, Dmitrieva, M., additional, Ivanchik, G., additional, Zafranskaya, M., additional, Hennino, M.-F., additional, Jomaa, Z., additional, Van Der Hauwaert, C., additional, Savary, G., additional, Buob, D., additional, Gnemmi, V., additional, Cauffiez, C., additional, and Glowacki, F., additional
- Published
- 2014
- Full Text
- View/download PDF
25. P078 L’administration néonatale d’un probiotique a des effets modulateurs durables sur la perméabilité intestinale soumis à un stress chez le porc adulte
- Author
-
Lalles, J.-P., primary, Bertacchini, D., additional, Savary, G., additional, Krüger, M., additional, and Smidt, H., additional
- Published
- 2013
- Full Text
- View/download PDF
26. Effects of weaning at 7d of age and of the level of energy intake on structural changes in the small intestine of piglets
- Author
-
Marion, Jessica, Biernat, M., Savary, G., Thomas, F., Zabielski, R., Le Huërou-Luron, Isabelle, Le Dividich, Jean, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration
- Subjects
[SDV] Life Sciences [q-bio] ,NIVEAU ALIMENTAIRE ,[SDV]Life Sciences [q-bio] ,[INFO]Computer Science [cs] ,[INFO] Computer Science [cs] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2002
27. Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy
- Author
-
Mickiewicz, M, Zabielski, R, Grenier, B, Le Normand, L, Savary, G, Holst, Jens Juul, Oswald, I P, Metges, C C, Guilloteau, P, Mickiewicz, M, Zabielski, R, Grenier, B, Le Normand, L, Savary, G, Holst, Jens Juul, Oswald, I P, Metges, C C, and Guilloteau, P
- Abstract
Protein level in the maternal diet plays a crucial role in fetal programming during pregnancy. Low or high protein level increases the risk of intrauterine growth retardation (IUGR). The aim of this study was to investigate the structural and functional development of the small intestine in piglets from sows fed a control (C, 12.1% protein), a high protein (HP, 30% protein), or a low protein (LP, 6.5% protein) diet during pregnancy. Newborns were classified as IUGR (birth weight =1.18 kg) and non-IUGR (birth weight >1.18 kg). The piglets were euthanized on postnatal day (PD)1, PD28 and PD188. The LP diet in non-IUGR neonates resulted in decreased body weight on PD1. The LP and HP diets resulted in both decreased body weight and delayed catch-up growth in the IUGR piglets. The HP and LP-diets increased the length of villi on PD1 in non-IUGRs but not in IUGRs. At birth, the expressions of Ki67 and active caspase 3 in mid-jejunum epithelium of HP and LP non-IUGR neonates were significantly lower as compared to C non-IUGRs whilst in IUGRs the respective expressions were as high as in C non-IUGRs. The postnatal dynamics of brush border enzyme activities and vacuolated enterocytes disappearance showed significant drop in enterocyte maturation in IUGR as compared to non-IUGR neonates. In conclusion, both HP and LP diets led to retarded development of non-IUGR piglets. In IUGR piglets both HP and LP diets resulted in delayed catch-up growth, without adaptive changes in brush border digestive enzymes.
- Published
- 2012
28. Implication de miR-21 dans le développement des lésions de fibrose interstitielle rénale
- Author
-
Glowacki, F., primary, Savary, G., additional, Buob, D., additional, Gnemmi, V., additional, Van Der Hauwaert, C., additional, Hazzan, M., additional, Pottier, N., additional, Perrais, M., additional, Noel, C., additional, Broly, F., additional, and Cauffiez, C., additional
- Published
- 2012
- Full Text
- View/download PDF
29. P044 La supplémentation en scFOS du régime maternel en peri-partum modifie la qualité immune du colostrum et le développement du système immunitaire intestinal des porcelets
- Author
-
Ferret-Bernard, S., primary, Le Bourgot, C., additional, Blat, S., additional, Menendez-Aparicio, E., additional, Savary, G., additional, Le Normand, L., additional, Grand, E., additional, Respondek, F., additional, and Le huërou-Luron, I., additional
- Published
- 2011
- Full Text
- View/download PDF
30. Impact du polymorphisme du gène de la cavéoline-1 sur la fonction du greffon après transplantation rénale
- Author
-
Glowacki, F., primary, Gnemmi, V., additional, Savary, G., additional, Lionet, A., additional, Buob, D., additional, Van Der Hauwaert, C., additional, Hazzan, M., additional, Broly, F., additional, Noel, C., additional, and Cauffiez, C., additional
- Published
- 2011
- Full Text
- View/download PDF
31. Pancreatic enzyme deficiency depends on dietary protein origin in milk-fed calves
- Author
-
Guilloteau, P., primary, Plodari, M., additional, Romé, V., additional, Savary, G., additional, Le Normand, L., additional, and Zabielski, R., additional
- Published
- 2011
- Full Text
- View/download PDF
32. Dietary sodium butyrate supplementation increases digestibility and pancreatic secretion in young milk-fed calves
- Author
-
Guilloteau, P., primary, Savary, G., additional, Jaguelin-Peyrault, Y., additional, Romé, V., additional, Le Normand, L., additional, and Zabielski, R., additional
- Published
- 2010
- Full Text
- View/download PDF
33. Impact of the composition of polysaccharide composite gels on small molecules diffusion: A rheological and NMR study
- Author
-
Savary, G., primary, Moreau, C., additional, and Cayot, N., additional
- Published
- 2010
- Full Text
- View/download PDF
34. Measurement of transport phenomena of volatile compounds: A review
- Author
-
Cayot, N., primary, Dury-Brun, C., additional, Karbowiak, T., additional, Savary, G., additional, and Voilley, A., additional
- Published
- 2008
- Full Text
- View/download PDF
35. Influence of the composition and the structure of fruit preparations on the aroma release and diffusion
- Author
-
Cayot, N., primary, Savary, G., additional, Guichard, E., additional, and Doublier, J.-L., additional
- Published
- 2006
- Full Text
- View/download PDF
36. Is Na-butyrate a growth factor in the preruminant calf? Preliminary results
- Author
-
Guilloteau, P., primary, Romé, V., additional, Le Normand, L., additional, Savary, G., additional, and Zabielski, R., additional
- Published
- 2004
- Full Text
- View/download PDF
37. P078 L’administration néonatale d’un probiotique a des effets modulateurs durables sur la perméabilité intestinale soumis à un stress chez le porc adulte
- Author
-
Lalles, J.-P., Bertacchini, D., Savary, G., Krüger, M., and Smidt, H.
- Published
- 2013
- Full Text
- View/download PDF
38. Describing ground surface texture using contact profilometry and fractal analysis
- Author
-
Brown, C.A., primary and Savary, G., additional
- Published
- 1991
- Full Text
- View/download PDF
39. Effects of level of feed intake on pancreatic exocrine secretions during the early postweaning period in piglets1.
- Author
-
Huguet, A., Savary, G., Bobillier, E., Lebreton, Y., and Huërou-Luron, I. Le
- Subjects
- *
PIGLETS , *EXOCRINE secretions , *PANCREATIC secretions , *DIGESTIVE enzymes , *TRYPSIN , *LIPASES , *AMYLASES , *ENZYMES - Abstract
The objective of this study was to determine the influence of the level of feed intake and a 2-d feed restriction period on the postweaning adaptation of pancreatic exocrine secretions. At 33 d of age, 18 piglets fitted with 2 permanents catheters (for pancreatic juice collection and reintroduction) were weaned and allocated to 1 of the following 2 dietary treatments for 5 d: restricted feed allocation (restricted) or gradually increasing feed allocation (control). Pancreatic juice was collected daily during both basal and prandial periods. The basal period was defined as the period from 1400 to 1700 h (i.e., 5 to 8 h after the morning meal), whereas the prandial period was defined as the period from 30 mm before to 60 mm after the morning meal (given at 0900). Digestive enzyme activities and anti-bacterial activity were determined. Pancreatic protein secretion was 44% less (P < 0.05) in restricted piglets than in control piglets during the basal period. Trypsin secretion was affected by feed-restriction of piglets. The meal did not affect protein and trypsin secretions in restricted piglets, whereas at d 3 postweaning, protein and trypsin secretions and trypsin specific activity in control piglets were 9-, 105-, and 25-fold greater (P < 0.00 1) during the first 30 mm after the meal than before the meal. Lipase and amylase secretions were not affected by variations in feed intake. The secretion of antibacterial activity in restricted piglets was greater (P < 0.05) than that of control piglets only at d 5. The extended feed restriction period increased the basal secretion of antibacterial activity (P = 0.09) and postprandial secretion of amylase (P = 0.05). In conclusion, a low level of feed intake during the early postweaning period decreased pancreatic protein and trypsin secretions, whereas a 2-d feed restriction period enhanced secretions of amylase and antibacterial activity. In addition, our results indicate that during periods of dietary adaptation, such as at weaning, measurements of enzyme activities in the tissue do not accurately reflect the enzyme secretion. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
40. Effects of level of feed intake on pancreatic exocrine secretions during the early postweaning period in piglets1.
- Author
-
Huguet, A., Savary, G., Bobillier, E., Lebreton, Y., and Huërou-Luron, I. Le
- Subjects
PIGLETS ,EXOCRINE secretions ,PANCREATIC secretions ,DIGESTIVE enzymes ,TRYPSIN ,LIPASES ,AMYLASES ,ENZYMES - Abstract
The objective of this study was to determine the influence of the level of feed intake and a 2-d feed restriction period on the postweaning adaptation of pancreatic exocrine secretions. At 33 d of age, 18 piglets fitted with 2 permanents catheters (for pancreatic juice collection and reintroduction) were weaned and allocated to 1 of the following 2 dietary treatments for 5 d: restricted feed allocation (restricted) or gradually increasing feed allocation (control). Pancreatic juice was collected daily during both basal and prandial periods. The basal period was defined as the period from 1400 to 1700 h (i.e., 5 to 8 h after the morning meal), whereas the prandial period was defined as the period from 30 mm before to 60 mm after the morning meal (given at 0900). Digestive enzyme activities and anti-bacterial activity were determined. Pancreatic protein secretion was 44% less (P < 0.05) in restricted piglets than in control piglets during the basal period. Trypsin secretion was affected by feed-restriction of piglets. The meal did not affect protein and trypsin secretions in restricted piglets, whereas at d 3 postweaning, protein and trypsin secretions and trypsin specific activity in control piglets were 9-, 105-, and 25-fold greater (P < 0.00 1) during the first 30 mm after the meal than before the meal. Lipase and amylase secretions were not affected by variations in feed intake. The secretion of antibacterial activity in restricted piglets was greater (P < 0.05) than that of control piglets only at d 5. The extended feed restriction period increased the basal secretion of antibacterial activity (P = 0.09) and postprandial secretion of amylase (P = 0.05). In conclusion, a low level of feed intake during the early postweaning period decreased pancreatic protein and trypsin secretions, whereas a 2-d feed restriction period enhanced secretions of amylase and antibacterial activity. In addition, our results indicate that during periods of dietary adaptation, such as at weaning, measurements of enzyme activities in the tissue do not accurately reflect the enzyme secretion. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
41. P044 La supplémentation en scFOS du régime maternel en peri-partum modifie la qualité immune du colostrum et le développement du système immunitaire intestinal des porcelets
- Author
-
Ferret-Bernard, S., Le Bourgot, C., Blat, S., Menendez-Aparicio, E., Savary, G., Le Normand, L., Grand, E., Respondek, F., and Le huërou-Luron, I.
- Published
- 2011
- Full Text
- View/download PDF
42. INTACS inserts for treating keratoconus
- Author
-
Colin, J., Cochener, B., Savary, G., Malet, F., and Holmes-Higgin, D.
- Published
- 2001
- Full Text
- View/download PDF
43. Correcting keratoconus with intracorneal rings
- Author
-
Colin, J., Cochener, B., Savary, G., and Malet, F.
- Published
- 2000
- Full Text
- View/download PDF
44. Approche des milieux agricoles du Tung Kula Ronghai (Thailande) à partir de données satellitaires (Landsat)
- Author
-
Bruneau, M., Kilian, Jean, Pairintra, C., and Savary, G.
- Subjects
méthode ,Cartographie ,Télédétection ,Traitement des données - Published
- 1984
45. Détection et cartographie des milieux agricoles à partir de données satellitaires. Synthèse des résultats acquis en Thaïlande et au Burkina Faso
- Author
-
Bruneau, M., Dosso, Mireille, Kilian, Jean, and Savary, G.
- Subjects
Cartographie ,Télédétection ,Phytoécologie ,méthode ,Collecte de données ,Zone rurale - Published
- 1985
46. Etude IBM-IRAT. Campagne de simulation des données de Spot. Haute-Volta : région de Bagré
- Author
-
Dosso, Mireille, Kilian, Jean, and Savary, G.
- Subjects
Télédétection ,Sciences du sol ,P31 - Levée et cartographie des sols ,P36 - Erosion, conservation et récupération des sols ,Bagre ,Traitement de l'information ,Pédologie ,Eau de ruissellement ,Hydrologie ,Cartographie ,Érosion ,Analyse de données ,Contrainte ,méthode ,U30 - Méthodes de recherche - Published
- 1983
47. Campagne de simulation des données SPOT : évaluation des sols dégradés et étude du réseau hydrographique (Bagré, Haute Volta)
- Author
-
Dosso, Mireille, Kilian, J., and Savary, G.
- Subjects
Hydrographie ,Télédétection ,Traitement des données ,Bagre - Published
- 1983
48. Cartes des états de surface. Tung Kula Ronghai. Composantes agraire et morphopédologique
- Author
-
Bruneau, M., Kilian, Jean, Pairintra, C., Savary, G., Bruneau, M., Kilian, Jean, Pairintra, C., and Savary, G.
- Published
- 1983
49. Effects of weaning at 7d of age and of the level of energy intake on structural changes in the small intestine of piglets
- Author
-
Jessica Marion, Biernat, M., Savary, G., Thomas, F., Zabielski, R., Isabelle Luron, and Jean Le Dividich
50. Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy
- Author
-
Mickiewicz, M., Zabielski, R., Grenier, B., Le Normand, L., Savary, G., Jens Juul Holst, Oswald, I. P., Metges, C. C., Guilloteau, P., Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA), Warsaw University of Life Sciences (SGGW), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), University of Copenhagen = Københavns Universitet (KU), Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), and Leibniz Institute for Farm Animal Biology (FBN)
- Subjects
Male ,[SDV]Life Sciences [q-bio] ,Sus scrofa ,Glucagon-Like Peptides ,Apoptosis ,Fetal Development ,Brush border enzymes ,Enterocyte ,Intrauterine growth retardation ,Glucagon-like peptide-2 ,Maturation ,Random Allocation ,Pregnancy ,animal modèle ,Birth Weight ,taux de protéine ,Intestinal Mucosa ,reproductive and urinary physiology ,alimentation ,Fetal Growth Retardation ,Caspase 3 ,truie ,bordure en brosse ,female genital diseases and pregnancy complications ,Jejunum ,embryonic structures ,retard de croissance intrautérine ,Cytokines ,Animal Nutritional Physiological Phenomena ,Female ,Dietary Proteins ,Cholecystokinin ,porcelet ,congenital, hereditary, and neonatal diseases and abnormalities ,Mitosis ,entérocyte ,gestation ,Animals ,RNA, Messenger ,Inflammation ,apoptose ,Body Weight ,Diet ,glucagon like peptide ,Pregnancy Complications ,enzyme ,Ki-67 Antigen ,Animals, Newborn ,porc - Abstract
International audience; Protein level in the maternal diet plays a crucial role in fetal programming during pregnancy. Low or high protein level increases the risk of intrauterine growth retardation (IUGR). The aim of this study was to investigate the structural and functional development of the small intestine in piglets from sows fed a control (C, 12.1% protein), a high protein (HP, 30% protein), or a low protein (LP, 6.5% protein) diet during pregnancy. Newborns were classified as IUGR (birth weight ≤1.18 kg) and non-IUGR (birth weight >1.18 kg). The piglets were euthanized on postnatal day (PD)1, PD28 and PD188. The LP diet in non-IUGR neonates resulted in decreased body weight on PD1. The LP and HP diets resulted in both decreased body weight and delayed catch-up growth in the IUGR piglets. The HP and LP-diets increased the length of villi on PD1 in non-IUGRs but not in IUGRs. At birth, the expressions of Ki67 and active caspase 3 in midjejunum epithelium of HP and LP non-IUGR neonates were significantly lower as compared to C non-IUGRs whilst in IUGRs the respective expressions were as high as in C non-IUGRs. The postnatal dynamics of brush border enzyme activities and vacuolated enterocytes disappearance showed significant drop in enterocyte maturation in IUGR as compared to non-IUGR neonates. In conclusion, both HP and LP diets led to retarded development of non-IUGR piglets. In IUGR piglets both HP and LP diets resulted in delayed catch-up growth, without adaptive changes in brush border digestive enzymes.
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