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Abstract We study the sphaleron solutions in two deformations of the $$\phi ^6$$ ϕ 6 model and analyze the oscillons originated from them. We find that the presence of internal modes plays a crucial role in the sphaleron collapse. The positive internal modes triggered by a squeezing of the sphaleron are able to change the direction of collapse. We provide an analytical understanding behind this phenomenon.

We present results from observations of 238 near-Earth objects (NEOs) obtained with the RATIR instrument on the 1.5 m robotic telescope at San Pedro Martir’s National Observatory in Mexico, in the frame of our multiobservatory, multifilter campaign. Our project is focused on rapid response photometric observations of NEOs with absolute magnitudes in the range 18.1–27.1 (diameter ≈ 600 and 10 m, respectively). Data with coverage in the near-infrared and visible range were analyzed with a nonparametric classification algorithm, while visible-only data were independently analyzed via Monte Carlo simulations and a 1-Nearest Neighbor method. The rapid response and the use of spectrophotometry allows us to obtain taxonomic classifications of subkilometer objects with small telescopes, representing a convenient characterization strategy. We present taxonomic classifications of the 87 objects observed in the visible and near-infrared. We also present the taxonomic distribution of an additional 151 objects observed in the visible. Our most accurate method suggests a nonfeatured-to-featured ratio of ≈0.75, which is consistent with the value found by the Mission Accessible Near-Earth Object Survey, which conducted a similar study using a spectral analysis. The results from the Monte Carlo method suggest a ratio of ≈0.8, although this method has some limitations. The 1-Nearest Neighbor method showed to be not suitable for NEO classifications.

BackgroundDyskeratosis congenita (DC) is a multisystem and ultra-rare hereditary disease characterized by somatic involvement, bone marrow failure, and predisposition to cancer. The main objective of this study is to describe the natural history of DC through a cohort of patients diagnosed in childhood and followed up for a long period of time.Material and methodsMulticenter, retrospective, longitudinal study conducted in patients followed up to 24 years since being diagnosed in childhood (between 1998 and 2020).ResultsFourteen patients were diagnosed with DC between the ages of 3 and 17 years (median, 8.5 years). They all had hematologic manifestations at diagnosis, and nine developed mucocutaneous manifestations during the first decade of life. Seven presented severe DC variants. All developed non-hematologic manifestations during follow-up. Mutations were identified in 12 patients. Thirteen progressed to bone marrow failure at a median age of 8 years [range, 3–18 years], and eight received a hematopoietic stem cell transplant. Median follow-up time was 9 years [range, 2–24 years]. Six patients died, the median age was 13 years [range, 6–24 years]. As of November 2022, eight patients were still alive, with a median age of 18 years [range, 6–32 years]. None of them have developed myeloblastic syndrome or cancer.ConclusionsDC was associated with high morbidity and mortality in our series. Hematologic manifestations appeared early and consistently. Non-hematologic manifestations developed progressively. No patient developed cancer possibly due to their young age. Due to the complexity of the disease multidisciplinary follow-up and adequate transition to adult care are essential.

Dust devils are common on Mars and understanding their dynamics is important to gain insights about the meteorology of the planet. Here, the authors show characteristics of a Martian dust devil and its sound from Perseverance rover multi-sensor data combined with modelling.

Abstract The information provided by a person with multiple sclerosis (MS) may anticipate changes in the course of the disease. To explore the role of a set of standardized patient-reported outcomes (PRO) in predicting disability progression in MS an observational study was conducted in two cohorts of 30 and 86 persons with progressive MS (pwPMS) and relapsing MS (pwRMS), respectively. The associations between baseline clinical, biochemical variables and results on MS quality of life scale (MusiQol), Modified Fatigue Impact Scale (MFIS) and Beck Depression Inventory II (BDI-II) were analyzed. The progression of disability after 2 years of follow-up in pwRMS was investigated. We show that PRO differentiated pwRMS and pwPMS cohorts with lower MusiQoL and higher MFIS and BDI-II scores in the latter. Only MFIS was correlated with disability in pwRMS and high scores in the physical MFIS domain associated with worse performance in 9HPT, and a trend in T25FW and SDMT. Instead, the cognitive MFIS domain was correlated with CHI3L1 in cerebrospinal fluid, a biomarker of progression. At the end of the study, global MFIS and BDI-II were found to be independent risk factors for disability independent of relapse. Although all PRO measures explored were altered in pwPMS, baseline MFIS discriminated current and prospective disability in pwRMS, identifying patients at risk of progression.

Abstract Tissue ischemia is a key risk factor in anastomotic leak (AL). Indocyanine green (ICG) is widely used in colorectal surgery to define the segments with the best vascularization. In an experimental model, we present a new system for quantifying ICG fluorescence intensity, the SERGREEN software. Controlled experimental study with eight pigs. In the initial control stage, ICG fluorescence intensity was analyzed at the level of two anastomoses, in the right and in the left colon. Control images of the two segments were taken after ICG administration. The images were processed with the SERGREEN program. Then, in the experimental ischemia stage, the inferior mesenteric artery was sectioned at the level of the anastomosis of the left colon. Fifteen minutes after the section, sequential images of the two anastomoses were taken every 30 min for the following 2 h. At the control stage, the mean scores were 134.2 (95% CI 116.3–152.2) for the right colon and 147 (95% CI 134.7–159.3) for the left colon (p = 0.174) (Scale RGB—Red, Green, Blue). The right colon remained stable throughout the experiment. In the left colon, intensity fell by 47.9 points with respect to the pre-ischemia value (p

Introduction: There is substantial evidence supporting that improving diet quality leads to improved health-related quality of life (HRQoL). Our major aim was to assess the effectiveness of a Mediterranean diet–based nutritional intervention to improve HRQoL in the context of a secondary prevention trial of depression. Secondarily to assess its effectiveness among adults aged 60 or more years. Methods: The PREDIDEP study is a 2-year multicentre, randomized, single-blinded nutritional trial. At baseline and at 1-year and 2-year follow-up, SF-36 health survey questionnaire was collected to evaluate participants' HRQoL (total and specific range for each of the 8 dimensions: 0 to 100 points). Mixed effect linear models were used to assess changes in HRQoL according to adherence to the Mediterranean diet. The trial was registered at ClinicalTrials.gov NCT03081065. Results: After 2 years of intervention, the Mediterranean Diet intervention group compared to control group (without nutritional intervention, only usual clinical care) showed an improvement in some dimensions of HRQoL such as Mental Health (7.22; 95 % CI = 2.22–12.22) (between-group difference: 6.79; 95 % CI −0.14–13.73, p = 0.055); Vitality (9.51; 95 % CI = 4.00–15.03) (between-group difference: 9.00; 95 % CI 1.75–16.25, p = 0.020); Mental Summary Component (2.83; 95 % CI = 0.55–5.11) (between-group difference: 1.17; 95 % CI = −1.96–4.30, p = 0.462); and General Health (10.70; 95 % CI = 5.58–15.81) (between-group difference: 6.20; 95 % CI = −0.89–13.28, p = 0.086). Similar results were observed for participants aged 60 or more years. Conclusion: The intervention based on Mediterranean diet in patients with previous depression seems to be effective in improving HRQoL, especially the mental dimensions. This effect is also observed among participants aged 60 or more years.

Resumen: Introducción y objetivos: La rotura de bíceps distal tiene una frecuencia de 1,2 casos por 100.000 habitantes. El tratamiento conservador supone un detrimento supinador del 40% y flexor del 30%, al igual que las transferencias al braquial. Nuestro objetivo es revisar nuestra experiencia con la reinserción anatómica. Material y métodos: Estudio comparativo de cohortes, entre una cohorte histórica, aunque reciente, en la que se aplicó doble abordaje, o de Boyd-Anderson, frente a una cohorte prospectiva donde se aplicó abordaje simple y doble. Tamaño muestral de 80 pacientes. Edad media de 48,9 ± 5,9 años. Analizamos lateralidad, tiempos para diagnóstico, prequirúrgico, quirúrgico, tipo de vía, tipo de reinserción, tiempo de rehabilitación, escala Mayo Elbow Performance Score (MEPS), estudio biomecánico y complicaciones. Seguimiento mínimo en 2 años y máximo en 7 años. Resultados: Tiempo para el diagnóstico, con mediana de 4 días. Tiempo prequirúrgico: 12,2 ± 6,4 días. Tiempo quirúrgico: 61,9 ± 15,7 min. Doble vía (Boyd-Anderson-Morrey) en el 78,8%, vía única (Henry) en el 21,2%. Reinserción transósea (45%), con anclaje roscado (40%) y con botón cortical (15%). Tiempo rehabilitador: 91 ± 29,7 días. MEPS: 88 ± 11,7 puntos. Déficit de fuerza flexora final del 28 ± 16,6%. Complicaciones: 1 caso de sinostosis radiocubital proximal, 2 neuroapraxias radiales y 5 casos con rigidez residual. Contraste de hipótesis: mejor resultado MEPS para doble vía (p = 0,009), con menos complicaciones (p = 0,008). Mayor dolor con botones corticales (p

Abstract Background In vitro embryo production (IVP) and embryo transfer (ET) are two very common assisted reproductive technologies (ART) in human and cattle. However, in pig, the combination of either procedures, or even their use separately, is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing ET in the long and contorted uterus of the sow. In addition, the potential impact of these two ART on the health of the offspring is unknown. We investigated here if the use of a modified IVP system, with natural reproductive fluids (RF) as supplements to the culture media, combined with a minimally invasive surgery to perform ET, affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular traits. Results The blastocyst rates obtained by both in vitro systems, conventional (C-IVP) and modified (RF-IVP), were similar. Pregnancy and farrowing rates were also similar. However, when compared to in vivo control (artificial insemination, AI), litter sizes of both IVP groups were lower, while placental efficiency was higher in AI than in RF-IVP. Gene expression studies revealed aberrant expression levels for PEG3 and LUM in placental tissue for C-IVP group when compared to AI, but not for RF-IVP group. Conclusions The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring.

Abstract Background The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive oil-enriched Mediterranean diet in reducing the recurrence of depression and improving the symptoms of this condition. Methods Multicenter, two-arm, parallel-group clinical trial. Arm 1, extra-virgin olive oil Mediterranean diet; Arm 2, control group without nutritional intervention. Dieticians are in charge of the nutritional intervention and regular contact with the participants. Contacts are made through our web platform (https://predidep.es/participantes/) or by phone. Recurrence of depression is assessed by psychiatrists and clinical psychologists through clinical evaluations (semi-structured clinical interviews: Spanish SCID-I). Depressive symptoms are assessed with the Beck Depression Inventory. Information on quality of life, level of physical activity, dietary habits, and blood, urine and stool samples are collected after the subject has agreed to participate in the study and once a year. Discussion To the best of our knowledge, the PREDI-DEP trial is the first ongoing randomized clinical trial designed to assess the role of the Mediterranean diet in the prevention of recurrent depression. It could be a cost-effective approach to avoid recurrence and improve the quality of life of these patients. Trial registration The study has been prospectively registered in the U.S. National Library of Medicine (https://clinicaltrials.gov) with NCT number: NCT03081065.

Resumen: El objetivo del Consenso Mexicano para el Tratamiento de la Hepatitis C fue el de desarrollar un documento como guía en la práctica clínica con aplicabilidad en México. Se tomó en cuenta la opinión de expertos en el tema con especialidad en: gastroenterología, infectología y hepatología. Se realizó una revisión de la bibliografía en MEDLINE, EMBASE y CENTRAL mediante palabras claves referentes al tratamiento de la hepatitis C. Posteriormente se evaluó la calidad de la evidencia mediante el sistema GRADE y se redactaron enunciados, los cuales fueron sometidos a voto mediante un sistema modificado Delphi, y posteriormente se realizó revisión y corrección de los enunciados por un panel de 34 votantes. Finalmente se clasificó el nivel de acuerdo para cada oración. Esta guía busca dar recomendaciones con énfasis en los nuevos antivirales de acción directa y de esta manera facilitar su uso en la práctica clínica. Cada caso debe ser individualizado según sus comorbilidades y el manejo de estos pacientes siempre debe ser multidisciplinario. Abstract: The aim of the Mexican Consensus on the Treatment of Hepatitis C was to develop clinical practice guidelines applicable to Mexico. The expert opinion of specialists in the following areas was taken into account: gastroenterology, infectious diseases, and hepatology. A search of the medical literature was carried out on the MEDLINE, EMBASE, and CENTRAL databases through keywords related to hepatitis C treatment. The quality of evidence was subsequently evaluated using the GRADE system and the consensus statements were formulated. The statements were then voted upon, using the modified Delphi system, and reviewed and corrected by a panel of 34 voting participants. Finally, the level of agreement was classified for each statement. The present guidelines provide recommendations with an emphasis on the new direct-acting antivirals, to facilitate their use in clinical practice. Each case must be individualized according to the comorbidities involved and patient management must always be multidisciplinary. Palabras clave: Consenso, Agentes antivirales de acción directa, Regímenes libres de interferón, Ribavirina, Keywords: Consensus, Direct-acting antiviral agents, Interferon-free regimens, Ribavirin

Abstract Background The aim of this study was twofold: (i) to assess the intrarater reliability of coracohumeral distance; (ii) to investigate the level of association between coracohumeral distance measured by ultrasonography, and pain-disability and shoulder range of movement, in patients suffering from chronic anterior shoulder pain. Methods An observational, cross sectional study was carried out. A convenience sample comprised of 87 patients with chronic anterior shoulder pain was assessed from 3 primary care centres. Main outcomes as pain and function were measured through the shoulder pain and disability index. Furthermore, shoulder range of movement-free of pain in shoulder elevation, as well as coracohumeral distance at both 0 and 60 degrees, were collected. Results Absence of any correlation was found between coracohumeral distance and shoulder pain and disability index at both 0 and 60 degrees of shoulder elevation. Furthermore, absence of any correlation was found between coracohumeral distance measurements and active shoulder range of movement -free of pain. Conclusions There was poor association between coracohumeral distance and shoulder pain and function, as well as with shoulder range of movement, in patients with chronic anterior shoulder pain. Hence, clinicians should consider, not only increasing this space, but also other possibilities in their therapies, when patients with anterior shoulder pain are treated. Trial registration ACTRN12614000144617 . Registered: 1st March 2014.

Objetivo: Describir la situación de accesibilidad y adherencia a tratamientos con drogas biológicas en pacientes de un servicio público de reumatología. Métodos: Estudio de corte transversal, observacional y retrospectivo que incluyó pacientes con gestión de DB. Variables: sociodemográficas, clínicas, tratamientos, tiempo desde el diagnóstico al acceso, adherencia (porcentaje de toma mensual y adecuada de la droga ≥75%); tiempo desde prescripción a administración; trámite administrativo realizado por entidad pública u obra social; certificado único de discapacidad (CUD).

Nowadays it is possible to measure accurately dense point clouds either with aerial/terrestrial laser scanning systems or with imagebased solutions (namely based on photogrammetric computer vision algorithms such as structure-from-motion (SfM)), from which highly detailed 3D models can be achieved. Besides, direct tools in the form of simple devices such as rulers, compass and plumblines are usually required in simple metric surveys, as well as high-end surveying and geodetic instruments such as robotized imagebased total stations and GNSS (probably to a lesser degree but still required) to set the archaeological/architectural recording project in a global reference frame. With all this gamut of image-based and range-based sensors and datasets (in the form of coordinates, point clouds or 3D models), in different coordinate systems (most of the times local for each device), lack of uniform scale, orientation and levelling, the fusion of data tends to be cumbersome. This paper presents an efficient way to fuse and merge different datasets in the form of point clouds/3D models and geodetic/UTM coordinates. The new developed 3DVEM – Register GEO software is able to handle datasets coming from both direct and indirect methods in order to provide unified and precise deliverables.

Cultural heritage managers in general and information users in particular are not usually used to deal with high-technological hardware and software. On the contrary, information providers of metric surveys are most of the times applying latest developments for real-life conservation and restoration projects. This paper addresses the software issue of handling and managing either 3D point clouds or (photorealistic) 3D models to bridge the gap between information users and information providers as regards the management of information which users and providers share as a tool for decision-making, analysis, visualization and management. There are not many viewers specifically designed to handle, manage and create easily animations of architectural and/or archaeological 3D objects, monuments and sites, among others. 3DVEM – 3D Viewer, Editor & Meter software will be introduced to the scientific community, as well as 3DVEM – Live and 3DVEM – Register. The advantages of managing projects with both sets of data, 3D point cloud and photorealistic 3D models, will be introduced. Different visualizations of true documentation projects in the fields of architecture, archaeology and industry will be presented. Emphasis will be driven to highlight the features of new userfriendly software to manage virtual projects. Furthermore, the easiness of creating controlled interactive animations (both walkthrough and fly-through) by the user either on-the-fly or as a traditional movie file will be demonstrated through 3DVEM – Live.

This paper describes the surveying process performed on the Church of San Ildefonso in Zamora (Spain) using Orthoware©, an innovative photogrammetric software tool specially designed for the digital reconstruction of cultural heritage. This software is the result of intense R&D at Metria Digital after several years producing heritage true orthoimages, plans and full color 3D models in a commercial environment. Orthoware allows true measurements and produces high quality true orthoimages and full color 3D models starting out from conventional digital photographs. This is a progressive tool designed for non-specialist users, providing intuitive and quick methods to visually diagnose the quality of the results. The Church of San Ildefonso in Zamora was built over a previously existing temple whose Romanesque construction dates back to the 11th century, although it is nowadays hidden among extensions and remodelings carried out up until 18th century. With a length of more than 30 meters, the original floor plan of the Church consists on three naves and three apses, although only one nave is visible now, covered by groin vault, and one semicircular apse partially hidden by the current building. The south front maintains the greater part of its Romanesque origins, in spite of being hidden and higher than the present ground level. At the feet of the temple a tower rises, whose first stage is Romanesque but which has been altered by numerous Baroque elements. The objective of the photogrammetric reconstruction was the integral survey of the monument, including its four façades, interior faces and roofs for the production of some true-orthoimages, cross-sections, longitudinal-sections and ground plans at scale 1/50 with an accuracy of 10 mm for the drawings and a pixel size below 10 mm for the synthetic imagery. The usual photogrammetric workflow for producing true-orthoimages and digital 3D models in cultural heritage depends to a great extent on finding and matching homologous features amongst various images. This is a time-consuming, repetitive and blind recognition process requiring some spatial intuition and experience from the user. Orthoware makes use of automatic image analysis and computer vision techniques to improve this processing. Its innovative graphic user interface allows full interactivity and corrections or refinements to be performed at any time providing intuitive diagnostics from partial results. This flow involves very intensive calculations achieved through a software development specific for GPU (Graphic Processing Unit), using OpenGL (Open Graphics Library) and DirectX. Therefore, a combination of manual and automatic techniques makes up the ideal tool for a production environment. The workflow presented herein allow users to reduce orthoimage production time from months to just a few weeks.

A partir de datos inéditos obtenidos mediante encuesta y ecocontadores, el artí - culo analiza la puesta en valor de los senderos como recurso turístico en el P.N. Sierra de las Nieves. Tras el análisis de los equipamientos que ofrece el Parque para la práctica del senderismo, el trabajo se centra en el análisis de la demanda. En primer lugar a través del volumen y ritmos estacionales de los visitantes, y en segundo lugar por el radio de atracción y la frecuencia de las visitas. Posterior - mente, tras medir la demanda, se hace una incursión en el análisis de la satisfac - ción de los usuarios, para concluir contrastando las valoraciones obtenidas conlos rasgos y perfiles que se consideran propios de la actividad y favorables para su realización en espacios de alto valor natural.

Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5%) had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively). The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48) years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p < 0.07). No relationship was seen between type of gastric reconstruction (Billroth I or II) and rate of Helicobacter pylori detection. Conclusions: Helicobacter pylori infection is frequent in patients with previous gastrectomy for non-neoplastic disease. The results of the study suggest that Helicobacter pylori infection may play a role in gastric stump cancer.Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5%) con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso) y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48) años. Se ha detectado un alto porcentaje de infección por Helicobacter pylori (100% en los pacientes con cáncer vs. 81,5% en los pacientes sin cáncer, p < 0,07). No se ha observado relación entre el tipo de reconstrucción gástrica (Billroth I o II) y el porcentaje de infección por Helicobacter pylori. Conclusiones: la infección por Helicobacter pylori es frecuente en pacientes gastrectomizados por patología benigna. Los resultados de este estudio sugieren que la infección por Helicobacter pylori podría jugar un papel en el cáncer gástrico.