12,315 results on '"S Davis"'
Search Results
2. Exploring the 'Learner Journey' of Students Undertaking a Professional Doctorate in Wales
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K. Hodgkin, S. Davis, A. McInch, and J. Littlewood
- Abstract
This paper reflects on the delivery of Professional Doctorate programmes from a sample of educational (EdD) and sustainable built environment (DSBE) practitioners at a Welsh University in the United Kingdom (UK). The paper explores the 'learner journey' of a sample of Professional Doctorate students as they navigate their studies during COVID-19 pandemic. A qualitative approach was adopted, and semi-structured questionnaires were used to collect data from students on the EdD and DSBE pathways. A thematic analysis was conducted, and the data presented explored how students have navigated their respective pathways and change projects across various modules, during their 'learning journey' and how successful they perceive that journey to be, in relation to a range of factors. The findings from this paper provide a unique insight into the experiences of Professional Doctorate students during a period of significant upheaval. Recommendations are provided for supervisors of Professional Doctorates, Higher Education Managers, as well as Policy Makers in supporting Professional Doctorate students during the studies. Best practice is highlighted with regard to practice-based approaches and demonstrates the differences across two academic disciplines. The use of agile digital and online learning in response to the COVID-19 pandemic further suggests an ongoing model for leadership in Higher Education.
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- 2024
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3. Exploring the Impacts of the Rebel Mascot: Insights Gained from School-Based Helping Professionals
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Eric S. Davis, Chloe Lancaster, and Cynthia Topdemir
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School mascots, including the Confederate Rebel, have come under scrutiny with calls to adopt more inclusive and representative symbols for all school stakeholders. Using qualitative methodology, we interviewed six school-based helping professionals in a southeastern US school district to examine their perceptions and experiences with the educational, personal, social, and community impacts associated with the Rebel school mascot. Four unique themes were identified from the participants and will be discussed along with implications and future research.
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- 2024
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4. The Sustainability of Content Enriched Shared Book Reading Vocabulary Practices and Preschool Emergent Bilinguals
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Sharolyn D. Pollard-Durodola, Jorge E. Gonzalez, Laura Saenz, and Heather S. Davis
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This study was part of a larger three-year investigation of the effectiveness of a small-group, content-focused (science, social studies) preschool shared book reading vocabulary intervention implemented with Spanish-speaking emergent bilinguals enrolled in a one-way dual-language bilingual program. A subset of bilingual preschool teachers (N = 23), representing treatment teachers from each of the three intervention years, was observed to understand the sustainability of the curricular approach and materials one, two, and three years post-intervention when instructional guidance was no longer provided by the research team. Findings from post-intervention observations and teacher self-reports suggest that teachers continued to implement the intervention approach and materials on some level but the explicit rich vocabulary instruction during the book reading experience was observed less the further teachers were out of the intervention. Implications for research are discussed.
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- 2024
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5. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
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Evans L. Mudanya, Molly Croghan, Ebonie S. Davis, Janci Finkley, Zehra Khan, Yvette A. Levy, and Lizbeth Román
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
6. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
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Janci Finkley, Molly Croghan, Ebonie S. Davis, Zehra Khan, Yvette A. Levy, Evans L. Mudanya, and Lizbeth Román
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
7. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
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Zehra Khan, Molly Croghan, Ebonie S. Davis, Janci Finkley, Yvette A. Levy, Evans L. Mudanya, and Lizbeth Román
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
8. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
- Author
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Lizbeth Román, Molly Croghan, Ebonie S. Davis, Janci Finkley, Zehra Khan, Yvette A. Levy, and Evans L. Mudanya
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2024
9. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
- Author
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Molly Croghan, Ebonie S. Davis, Janci Finkley, Zehra Khan, Yvette A. Levy, Evans L. Mudanya, and Lizbeth Román
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2024
10. The Postsecondary Success of Historically Marginalized Black and Latino Male Students: Examining Factors That Impact College Readiness Preparation and Persistence
- Author
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Yvette A. Levy, Molly Croghan, Ebonie S. Davis, Janci Finkley, Zehra Khan, Evans L. Mudanya, and Lizbeth Román
- Abstract
This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories in higher education. Through thematic analysis, the research aims to uncover the unique insights shared by both educators and students, highlighting the interconnectedness of their experiences. The primary objective of this doctoral thesis is to ameliorate the gap between theoretical inquiry and practical application by providing actionable guidance tailored for educators, counselors, and policymakers. The aim is to augment college readiness initiatives and bolster persistence rates specifically among historically marginalized Black and Latino male students. By integrating the voices of both students and educators, this research seeks to foster a more inclusive and informed approach to addressing the educational inequities encountered by this demographic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2024
11. Decision support for selecting a shortlist of electricity-saving options: a modified SMAA approach
- Author
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I Durbach and S Davis
- Subjects
General Works - Abstract
This paper describes an application providing decision support for generating a shortlist of promising electricity-saving options for households in South Africa. The decision problem is characterised by constraints on time and other resources, and by substantial uncertainty around the preferences for energy-related attributes and the performance of alternatives on those attributes. We use a stochastic multi-criteria acceptability analysis model to incorporate preferential uncertainties, and adapt this for use with quantiles and other "simplified" formats for representing uncertain attribute evaluations.
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- 2012
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12. Sketching AI Concepts with Capabilities and Examples: AI Innovation in the Intensive Care Unit.
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Nur Yildirim, Susanna Zlotnikov, Deniz Sayar, Jeremy M. Kahn, Leigh A. Bukowski, Sher Shah Amin, Kathryn A. Riman, Billie S. Davis, John S. Minturn, Andrew J. King, Dan Ricketts, Lu Tang 0003, Venkatesh Sivaraman, Adam Perer, Sarah Masud Preum, James McCann, and John Zimmerman
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- 2024
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13. GRIT: GAN Residuals for Paired Image-to-Image Translation.
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Saksham Suri, Moustafa Meshry, Larry S. Davis, and Abhinav Shrivastava
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- 2024
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14. Building an Open-Vocabulary Video CLIP Model With Better Architectures, Optimization and Data.
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Zuxuan Wu, Zejia Weng, Wujian Peng, Xitong Yang, Ang Li 0001, Larry S. Davis, and Yu-Gang Jiang
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- 2024
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15. A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
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Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, and Stanley H. Appel
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Trial registration ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153
- Published
- 2023
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16. Identification of candidate novel production variants on the Bos taurus chromosome X
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H. Trebes, Y. Wang, E. Reynolds, K. Tiplady, C. Harland, T. Lopdell, T. Johnson, S. Davis, B. Harris, R. Spelman, and C. Couldrey
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X chromosome ,genome-wide association study ,genomic selection ,milk production ,Dairy processing. Dairy products ,SF250.5-275 ,Dairying ,SF221-250 - Abstract
ABSTRACT: Chromosome X is often excluded from bovine genetic studies due to complications caused by the sex specific nature of the chromosome. As chromosome X is the second largest cattle chromosome and makes up approximately 6% of the female genome, finding ways to include chromosome X in dairy genetic studies is important. Using female animals and treating chromosome X as an autosome, we performed X chromosome inclusive genome-wide association studies in the selective breeding environment of the New Zealand dairy industry, aiming to identify chromosome X variants associated with milk production traits. We report on the findings of these genome-wide association studies and their potential effect within the dairy industry. We identify missense mutations in the MOSPD1 and CCDC160 genes that are associated with decreased milk volume and protein production and increased fat production. Both of these mutations are exonic SNP that are more prevalent in the Jersey breed than in Holstein-Friesians. Of the 2 candidates proposed it is likely that only one is causal, though we have not been able to identify which is more likely.
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- 2023
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17. The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model
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M Bond, G Rogers, J Peters, R Anderson, M Hoyle, A Miners, T Moxham, S Davis, P Thokala, A Wailoo, M Jeffreys, and C Hyde
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alzheimer’s disease ,acetylcholinesterase inhibitor ,donepezil ,galantamine ,rivastigmine ,memantine ,systematic review ,economic model ,quality of life ,Medical technology ,R855-855.5 - Abstract
Background: Alzheimer’s disease (AD) is the most commonly occurring form of dementia. It is predominantly a disease of later life, affecting 5% of those over 65 in the UK. Objectives: Review and update guidance to the NHS in England and Wales on the clinical effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine [acetylcholinesterase inhibitors (AChEIs)] and memantine within their licensed indications for the treatment of AD, which was issued in November 2006 (amended September 2007 and August 2009). Data sources: Electronic databases were searched for systematic reviews and/or meta-analyses, randomised controlled trials (RCTs) and ongoing research in November 2009 and updated in March 2010; this updated search revealed no new includable studies. The databases searched included The Cochrane Library (2009 Issue 4, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials), MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, PsycINFO, EconLit, ISI Web of Science Databases – Science Citation Index, Conference Proceedings Citation Index, and BIOSIS; the Centre for Reviews and Dissemination (CRD) databases – NHS Economic Evaluation Database, Health Technology Assessment, and Database of Abstracts of Reviews of Effects. Review methods: The clinical effectiveness systematic review was undertaken following the principles published by the NHS CRD. We included RCTs whose population was people with AD. The intervention and comparators depended on disease severity, measured by the Mini Mental State Examination (MMSE). Interventions: mild AD (MMSE 21–26) – donepezil, galantamine and rivastigmine; moderate AD (MMSE 10–20) – donepezil, galantamine, rivastigmine and memantine; severe AD (MMSE 99% probability that the AChEIs are more cost-effective than BSC. These analyses assume that the AChEIs have no effect on survival. For the AChEIs, in people with mild to moderate AD, the probabilistic sensitivity analyses suggested that donepezil is the most cost-effective, with a 28% probability of being the most cost-effective option at a WTP of £30,000 per QALY (27% at a WTP of £20,000 per QALY). In the deterministic results, donepezil dominates the other drugs and BSC, which, along with rivastigmine patches, are associated with greater costs and fewer QALYs. Thus, although galantamine has a slightly cheaper total cost than donepezil (£69,592 vs £69,624), the slightly greater QALY gains from donepezil (1.616 vs 1.617) are enough for donepezil to dominate galantamine.The probability that memantine is cost-effective in a moderate to severe cohort compared with BSC at a WTP of £30,000 per QALY is 38% (and 28% at a WTP of £20,000 per QALY). The deterministic ICER for memantine is £32,100 per/QALY and the probabilistic ICER is £36,700 per/QALY. Limitations: Trials were of 6 months maximum follow-up, lacked reporting of key outcomes, provided no subgroup analyses and used insensitive measures. Searches were limited to English language, The model does not include behavioural symptoms and there is uncertainty about the model structure and parameters. Conclusions: The additional clinical effectiveness evidence identified continues to suggest clinical benefit from the AChEIs in alleviating AD symptoms, although there is debate about the magnitude of the effect. Although there is also new evidence on the effectiveness of memantine, it remains less supportive of this drug’s use than the evidence for AChEIs. The conclusions concerning cost-effectiveness are quite different from the previous assessment. This is because both the changes in effectiveness and costs between drug use and non-drug use underlying the ICERs are very small. This leads to highly uncertain results, which are very sensitive to change. Research priorities: RCTs to include mortality, time to institutionalisation and quality of life, powered for subgroup analysis. Funding: The National Institute for Health Research Health Technology Assessment programme.
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- 2012
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18. Modelling household responses to energy efficiency interventions via system dynamics and survey data
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S Davis and I Durbach
- Subjects
General Works - Abstract
An application of building a system dynamics model of the way households might respond to interventions aimed at reducing energy consumption (specifically the use of electricity) is described in this paper. A literature review of past research is used to build an initial integrated model of household consumption, and this model is used to generate a small number of research hypotheses about how households possessing different characteristics might react to various types of interventions. These hypotheses are tested using data gathered from an efficiency intervention conducted in a town in the South African Western Cape in which households were able to exchange regular light bulbs for more efficient compact fluorescent lamp light bulbs. Our experiences are (a) that a system dynamics approach proved useful in advancing a non-traditional point of view for which, for historical and economic reasons, data were not abundantly available; (b) that, in areas where traditional models are heavily quantitative, some scepticism to a system dynamics model may be expected; and (c) that a statistical comparison of model results by means of empirical data may be an effective tool in reducing such scepticism.
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- 2010
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19. A preliminary model-based assessment of the cost-utility of a screening programme for early age-related macular degeneration
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J Karnon, C Czoski-Murray, K Smith, C Brand, U Chakravarthy, S Davis, N Bansback, C Beverley, A Bird, S Harding, I Chisholm, and Y Yang
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Medical technology ,R855-855.5 - Published
- 2008
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20. Taxanes for the adjuvant treatment of early breast cancer: systematic review and economic evaluation
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S Ward, E Simpson, S Davis, D Hind, A Rees, and A Wilkinson
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Medical technology ,R855-855.5 - Published
- 2007
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21. Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis
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J Kanis, M Stevenson, E McCloskey, S Davis, and M Lloyd-Jones
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Medical technology ,R855-855.5 - Published
- 2007
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22. The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women
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M Stevenson, S Davis, M Lloyd-Jones, and C Beverley
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Medical technology ,R855-855.5 - Published
- 2007
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23. A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis
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M Stevenson, M Lloyd Jones, E De Nigris, N Brewer, S Davis, and J Oakley
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Medical technology ,R855-855.5 - Published
- 2005
- Full Text
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24. Oral ulcerations in an immunosuppressed pediatric patient
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Ansley DeVore, MD, Margaret S. Newsome, MD, and Loretta S. Davis, MD
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aphthous ulcers ,mTOR inhibitor-associated stomatitis ,mucositis ,oral ulcerations ,sirolimus ,stomatitis ,Dermatology ,RL1-803 - Published
- 2023
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25. Association Between Poor Sleep and Myocardial Infarction in Patients with Psoriasis: Findings from a Cross-Sectional Study with the National Psoriasis Foundation
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Riley K. Spencer, Joy Q. Jin, Kareem G. Elhage, Mitchell S. Davis, Marwa Hakimi, George Gondo, Wilson Liao, and Tina Bhutani
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Myocardial infarction ,National Psoriasis Foundation ,Psoriasis ,Psoriatic arthritis ,Sleep disturbance ,Dermatology ,RL1-803 - Abstract
Abstract Background Poor sleep quality occurs in patients with psoriasis at rates nearly twice that of the general population. Chronic sleep impairment is an independent risk factor for the development of cardiovascular disease. Here, we examine the association between sleep quantity and history of myocardial infarction in patients with psoriasis. Methods This observational, cross-sectional study utilized data from the 2020 National Psoriasis Foundation Annual Survey. Effect estimates were obtained using a multivariate logistic regression model, which controlled for prespecified covariates. Results Based on data from 1405 individuals with psoriasis, our analysis demonstrated a significant association between sleep quantity and history of myocardial infarction: odds ratio (OR) 0.67 [95% confidence interval (CI) 0.49–0.92], p = 0.012. The association was not significantly influenced by psoriasis severity (OR 1.01, [95% CI 0.99–1.03], p = 0.38), comorbid psoriatic arthritis (OR 1.06, [95% CI 0.48–2.38], p = 0.88), sleep apnea, or other traditional risk factors for myocardial infarction. Conclusion Our analyses indicate an association between sleep quantity and history of myocardial infarction in patients with psoriasis. For each hour increase in average nightly sleep, patients with psoriasis have a 33% decrease in the odds of having a history of myocardial infarction. The chief limitation of this study is its cross-sectional design limiting ascertainment of causality.
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- 2023
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26. Quality of fresh and cryopreserved bovine sperm is reduced by BPA and BPF exposure
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Ola S Davis, Vivien B Truong, Katie D Hickey, and Laura A Favetta
- Subjects
spermatozoa ,bisphenol ,motility ,capacitation ,cryopreservation ,Reproduction ,QH471-489 ,Gynecology and obstetrics ,RG1-991 - Abstract
Bisphenol A (BPA) is an endocrine-disrupting compound, used as the key monomer of polycarbonate plastics and epoxy resins. BPA has been detected in both humans and farm animals and has been correlated with decreased sperm counts and motility. BPS and BPF are structural analogs of BPA and are increasingly being used in manufacturing as BPA substitutes. In this study, we aim to assess the direct outcomes of BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure on bovine sperm parameters in vitro to elucidate how they affect sperm quality and fertilization potential, and to assess whether BPS and/or BPF are less harmful than BPA. Sperm from three or more bulls was obtained from either fresh samples or cryopreserved straws and exposed to 0.05 mg/mL of BPA, BPS, and BPF in vitro. After 4 h incubation, motility, capacitation, apoptosis/necrosis, and mitochondrial membrane potential levels were measured by computer-assisted sperm analysis or computational flow cytometry. Results showed that BPA exposure significantly reduced both fresh and cryopreserved sperm motility, capacitation, viability and mitochondrial membrane potential levels. Furthermore, BPF significantly decreased motility, capacitation and mitochondrial membrane potential in cryopreserved sperm only. BPS did not have any significant effects on any of the parameters measured. Our results suggest that BPA is the most harmful to sperm, while BPF is toxic under certain conditions, and BPS seems to be the least detrimental. Overall, this study provides an understanding of how the ubiquitous environmental chemicals, bisphenols, may impact male fertility even after ejaculation.
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- 2023
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27. Large‐scale human celebrations increase global light pollution
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Francisco Ramírez, Yago Cordón, Diego García, Airam Rodríguez, Marta Coll, Lloyd S. Davis, Andre Chiaradia, and Josep L. Carrasco
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artificial lights at night ,light pollution ,social aggregations ,VIIRS ,Human ecology. Anthropogeography ,GF1-900 ,Ecology ,QH540-549.5 - Abstract
Abstract Culturally dependent human social behaviours involving artificial light usage can potentially affect light pollution patterns and thereby impact the night‐time ecology in populated areas, although to date this has not been examined globally. By analysing continuous (monthly), highly resolved, spatially explicit data on global night lights (Visible and Infrared Imaging Radiometer Suite–Day/Night Band‐VIIRS‐DNB; 2014–2019) with circular statistical techniques, we evaluated whether macro‐cultural activities involving social aggregations and the use of artificial lights shape annual lighting patterns globally. Scheduled routines associated with cultural‐specific festivities appear to be important drivers of observed seasonal patterns in urban night‐time lights. For instance, the display of Christmas lights between Christmas and Epiphany Day celebrations (December–January) coincides with the annual peak in urban night‐time light intensity in Christian countries. Analogously, night celebrations during the Holy Month of Ramadam (from May to July) or the month‐long period of Karthika Masam (from October to November) fits with annual night light peaks in Muslim and Hindu countries. Annual peaks of urban light intensity in China and Vietnam also match with Chinese and Vietnamese (Tê't) New Year celebrations (January–February). In contrast, predominantly Buddhist countries, which do not have such prominent and prolonged celebrations involving artificial lights, show a relatively uniform distribution of night light peaks throughout the annual cycle. Social behaviour and sociocultural contexts help explain how people modify the global nightscape and contribute to light pollution globally. Understanding the cultural contexts responsible for peaks in artificial light usage is an important first step if humans are to mitigate any deleterious effects associated with global increases in night‐time light pollution. Read the free Plain Language Summary for this article on the Journal blog.
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- 2023
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28. 'The most culturally safe training I’ve ever had': the co-design of a culturally safe Managing hepatitis B training course with and for the Aboriginal health workforce of the Northern Territory of Australia
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Kelly Hosking, Teresa De Santis, Emily Vintour-Cesar, Phillip Merrdi Wilson, Linda Bunn, George Garambaka Gurruwiwi, Shiraline Wurrawilya, Sarah Mariyalawuy Bukulatjpi, Sandra Nelson, Cheryl Ross, Paula Binks, Phoebe Schroder, Joshua S. Davis, Sean Taylor, Christine Connors, Jane Davies, and on behalf of the Hep B PAST partnership
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Aboriginal and Torres Strait Islander health ,Aboriginal health workforce ,Cultural safety ,Health education ,Training ,Equity ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The Aboriginal health workforce provide responsive, culturally safe health care. We aimed to co-design a culturally safe course with and for the Aboriginal health workforce. We describe the factors which led to the successful co-design, delivery, and evaluation of the “Managing hepatitis B” course for the Aboriginal health workforce. Methods A Participatory Action Research approach was used, involving ongoing consultation to iteratively co-design and then develop course content, materials, and evaluation tools. An Aboriginal and Torres Strait Islander research and teaching team received education in chronic hepatitis B and teaching methodologies. Pilot courses were held, in remote communities of the Northern Territory, using two-way learning and teach-back methods to further develop the course and assess acceptability and learnings. Data collection involved focus group discussions, in-class observations, reflective analysis, and use of co-designed and assessed evaluation tools. Results Twenty-six participants attended the pilot courses. Aboriginal and Torres Strait Islander facilitators delivered a high proportion of the course. Evaluations demonstrated high course acceptability, cultural safety, and learnings. Key elements contributing to success and acceptability were acknowledging, respecting, and integrating cultural differences into education, delivering messaging and key concepts through an Aboriginal and Torres Strait Islander lens, using culturally appropriate approaches to learning including storytelling and visual teaching methodologies. Evaluation of culturally safe frameworks and findings from the co-design process led to the creation of a conceptual framework, underpinned by meeting people’s basic needs, and offering a safe and comfortable environment to enable productive learning with attention to the following: sustenance, financial security, cultural obligations, and gender and kinship relationships. Conclusions Co-designed education for the Aboriginal health workforce must embed principles of cultural safety and meaningful community consultation to enable an increase in knowledge and empowerment. The findings of this research can be used to guide the design of future health education for First Nations health professionals and to other non-dominant cultures. The course model has been successfully transferred to other health issues in the Northern Territory.
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- 2023
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29. Lessons learned in coupling atmospheric models across scales for onshore and offshore wind energy
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S. E. Haupt, B. Kosović, L. K. Berg, C. M. Kaul, M. Churchfield, J. Mirocha, D. Allaerts, T. Brummet, S. Davis, A. DeCastro, S. Dettling, C. Draxl, D. J. Gagne, P. Hawbecker, P. Jha, T. Juliano, W. Lassman, E. Quon, R. K. Rai, M. Robinson, W. Shaw, and R. Thedin
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Renewable energy sources ,TJ807-830 - Abstract
The Mesoscale to Microscale Coupling team, part of the U.S. Department of Energy Atmosphere to Electrons (A2e) initiative, has studied various important challenges related to coupling mesoscale models to microscale models for the use case of wind energy development and operation. Several coupling methods and techniques for generating turbulence at the microscale that is subgrid to the mesoscale have been evaluated for a variety of cases. Case studies included flat-terrain, complex-terrain, and offshore environments. Methods were developed to bridge the terra incognita, which scales from about 100 m through the depth of the boundary layer. The team used wind-relevant metrics and archived code, case information, and assessment tools and is making those widely available. Lessons learned and discerned best practices are described in the context of the cases studied for the purpose of enabling further deployment of wind energy.
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- 2023
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30. SoK: On Named Content and Inter-domain Routing.
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Jeremiah S. Davis and Kenneth L. Calvert
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- 2023
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31. FlexNeRF: Photorealistic Free-viewpoint Rendering of Moving Humans from Sparse Views.
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Vinoj Jayasundara 0001, Amit Agrawal, Nicolas Heron, Abhinav Shrivastava, and Larry S. Davis
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- 2023
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32. Chromatin alternates between A and B compartments at kilobase scale for subgenic organization
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Hannah L. Harris, Huiya Gu, Moshe Olshansky, Ailun Wang, Irene Farabella, Yossi Eliaz, Achyuth Kalluchi, Akshay Krishna, Mozes Jacobs, Gesine Cauer, Melanie Pham, Suhas S. P. Rao, Olga Dudchenko, Arina Omer, Kiana Mohajeri, Sungjae Kim, Michael H. Nichols, Eric S. Davis, Dimos Gkountaroulis, Devika Udupa, Aviva Presser Aiden, Victor G. Corces, Douglas H. Phanstiel, William Stafford Noble, Guy Nir, Michele Di Pierro, Jeong-Sun Seo, Michael E. Talkowski, Erez Lieberman Aiden, and M. Jordan Rowley
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Science - Abstract
Abstract Nuclear compartments are prominent features of 3D chromatin organization, but sequencing depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally studied at a finer scale, but the impact of looping on proximal interactions remains enigmatic. Here, we critically examine nuclear compartments and CTCF loop-proximal interactions using a combination of in situ Hi-C at unparalleled depth, algorithm development, and biophysical modeling. Producing a large Hi-C map with 33 billion contacts in conjunction with an algorithm for performing principal component analysis on sparse, super massive matrices (POSSUMM), we resolve compartments to 500 bp. Our results demonstrate that essentially all active promoters and distal enhancers localize in the A compartment, even when flanking sequences do not. Furthermore, we find that the TSS and TTS of paused genes are often segregated into separate compartments. We then identify diffuse interactions that radiate from CTCF loop anchors, which correlate with strong enhancer-promoter interactions and proximal transcription. We also find that these diffuse interactions depend on CTCF’s RNA binding domains. In this work, we demonstrate features of fine-scale chromatin organization consistent with a revised model in which compartments are more precise than commonly thought while CTCF loops are more protracted.
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- 2023
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33. A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter
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Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky, Harry LeVine, Michael Grundman, Anthony O. Caggiano, John R. Cirrito, Susan M. Catalano, and Mary E. Hamby
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2023
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34. Impact loading in female runners with single and multiple bone stress injuries during fresh and exerted conditions
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Kristin L. Popp, Jereme Outerleys, Sarah Gehman, Margaret Garrahan, Sara Rudolph, Elizabeth Loranger, Kathryn E. Ackerman, Adam S. Tenforde, Mary L. Bouxsein, and Irene S. Davis
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Biomechanics ,Bone stress injuries ,Fatigue ,Runners ,Stress fracture ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Background: Bone stress injuries (BSIs) are common in female runners, and recurrent BSI rates are high. Previous work suggests an association between higher impact loading during running and tibial BSI. However, it is unknown whether impact loading and fatigue-related loading changes discriminate women with a history of multiple BSIs. This study compared impact variables at the beginning of a treadmill run to exertion and the changes in those variables with exertion among female runners with no history of BSI as well as among those with a history of single or multiple BSIs. Methods: We enrolled 45 female runners (aged 18–40 years) for this cross-sectional study: having no history of diagnosed lower extremity BSI (N-BSI, n = 14); a history of 1 lower extremity BSI (1-BSI, n = 16); and diagnosed by imaging, or a history of multiple (≥3) lower extremity BSIs (M-BSI, n = 15). Participants completed a 5-km race speed run on an instrumented treadmill while wearing an Inertial Measurement Unit. The vertical average loading rate (VALR), vertical instantaneous loading rate (VILR), vertical stiffness during impact via instrumented treadmill, and tibial shock determined as the peak positive tibial acceleration via Inertial Measurement Unit were measured at the beginning and the end of the run. Results: There were no differences between groups in VALR, VILR, vertical stiffness, or tibial shock in a fresh or exerted condition. However, compared to N-BSI, women with M-BSI had greater increase with exertion in VALR (–1.8% vs. 6.1%, p = 0.01) and VILR (1.5% vs. 4.8%, p = 0.03). Similarly, compared to N-BSI, vertical stiffness increased more with exertion among women with M-BSI (–0.9% vs. 7.3%, p = 0.006) and 1-BSI (–0.9% vs. 1.8%, p = 0.05). Finally, compared to N-BSI, the increase in tibial shock from fresh to exerted condition was greater among women with M-BSI (0.9% vs. 5.5%, p = 0.03) and 1-BSI (0.9% vs. 11.2%, p = 0.02). Conclusion: Women with 1-BSI or M-BSIs experience greater exertion-related increases in impact loading than women with N-BSI. These observations imply that exertion-related changes in gait biomechanics may contribute to risk of BSI.
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- 2023
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35. Mechanistic models project bird invasions with accuracy
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Diederik Strubbe, Laura Jiménez, A. Márcia Barbosa, Amy J. S. Davis, Luc Lens, and Carsten Rahbek
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Science - Abstract
Abstract Invasive species pose a major threat to biodiversity and inflict massive economic costs. Effective management of bio-invasions depends on reliable predictions of areas at risk of invasion, as they allow early invader detection and rapid responses. Yet, considerable uncertainty remains as to how to predict best potential invasive distribution ranges. Using a set of mainly (sub)tropical birds introduced to Europe, we show that the true extent of the geographical area at risk of invasion can accurately be determined by using ecophysiological mechanistic models that quantify species’ fundamental thermal niches. Potential invasive ranges are primarily constrained by functional traits related to body allometry and body temperature, metabolic rates, and feather insulation. Given their capacity to identify tolerable climates outside of contemporary realized species niches, mechanistic predictions are well suited for informing effective policy and management aimed at preventing the escalating impacts of invasive species.
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- 2023
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36. A novel record of African wild dogs (Lycaon pictus) in Vwaza Marsh Wildlife Reserve, Malawi
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Olivia Sievert, Matthias Hammer, Eleanor Comley, Benjamin Hintz, William O. Mgoola, and Robert S. Davis
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camera traps ,dispersal ,large carnivores ,Malawi ,Zambia ,Ecology ,QH540-549.5 - Abstract
Abstract Most African wild dog (Lycaon pictus) populations are in decline and, due to habitat fragmentation and conflict rates in areas of higher anthropogenic land‐use, are primarily restricted to protected areas. As a species that occurs at low densities, with a strict reproductive social structure, wild dogs rely on long‐range dispersal to facilitate colonization, reproduction, and pack formation. In Malawi, large carnivores have been subject to widespread population decline and several protected areas have a reduced large carnivore guild, including the loss of resident wild dog populations. Here, during a biodiversity monitoring camera trap survey, we captured a novel record of wild dogs in Vwaza Marsh Wildlife Reserve (Vwaza), Malawi. The 11 photographic captures of potentially three individual wild dogs represent the first documented evidence of the species in Vwaza and the first record since an unconfirmed report in 2011. We hypothesize that this group of wild dogs moved into Vwaza through the Malawi‐Zambia Transfrontier Conservation Area (MZTFCA), with the MZTFCA linking protected areas in Malawi with the Luangwa Valley, Zambia. The evidence provided here, and similar documentation in Kasungu National Park, Malawi, show that large carnivores can potentially move through the MZTFCA into protected areas in Malawi. We argue that the MZTFCA provides an important dispersal corridor that could help facilitate the recolonization of wild dogs, and other large carnivores, in Malawian protected areas. However, further research is needed to assess the permeability and status of the MZTFCA corridor into Malawi. We show that camera traps can be useful to document novel records of rare species and can be used to inform conservation management planning.
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- 2023
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37. FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells
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Chen Wang, Hui Sun, John S. Davis, Xiaojie Wang, Lijun Huo, Nan Sun, Qianzhi Huang, Xiangmin Lv, Cheng Wang, Chunbo He, Changjiu He, Yang Zhou, Jiyun Wu, Liguo Yang, and Guohua Hua
- Subjects
Cytology ,QH573-671 - Abstract
Abstract Female subfertility is an increasing reproductive issue worldwide, which is partially related to abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary physical support and microenvironment for follicular development, play critical roles in maintaining female fertility. We previously showed that ectopic expression of four and a half LIM domains 2 (FHL2) promoted ovarian granulosa cell tumor progression. However, its function in follicular development and fertility remains unknown. Here, we confirmed that FHL2 is highly expressed in human and mouse ovaries. FHL2 immunosignals were predominantly expressed in ovarian GCs. A Fhl2 knockout (KO) mouse model was generated to examine its roles in follicular development and fertility. Compared with wildtype, knockout of Fhl2 significantly decreased female litter size and offspring number. Furthermore, Fhl2 deficiency reduced ovarian size and impaired follicular development. RNA-sequencing analysis of GCs isolated from either KO or WT mice revealed that, Fhl2 deletion impaired multiple biological functions and signaling pathways, such as Ovarian Putative Early Atresia Granulosa Cell, ErbB, Hippo/YAP, etc. In vitro studies confirmed that FHL2 silencing suppressed GCs growth and EGF-induced GCs proliferation, while its overexpression promoted GC proliferation and decreased apoptosis. Mechanistic studies indicated that FHL2, via forming complexes with transcriptional factors AP-1 or NF-κB, regulated Egf and Egfr expression, respectively. Besides, FHL2 depletion decreased YAP1 expression, especially the active form of YAP1 (nuclear YAP1) in GCs of growing follicles. EGF, serving as an autocrine/paracrine factor, not only induced FHL2 expression and nuclear accumulation, but also stimulated YAP1 expression and activation. Collectively, our study suggests that FHL2 interacts with EGFR and Hippo/YAP signaling to regulate follicular development and maintain fertility. This study illuminates a novel mechanism for follicular development and a potential therapeutic target to address subfertility.
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- 2023
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38. Living with Psoriasis Vulgaris and Multi-Treatment Failure: A Patient and Dermatologist Perspective
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Riley K. Spencer, Kareem G. Elhage, Joy Q. Jin, Mitchell S. Davis, Marwa Hakimi, Tina Bhutani, Howard Chang, and Wilson Liao
- Subjects
Biologics ,IL-17 inhibitors ,IL-23 inhibitors ,JAK inhibitors ,Phototherapy ,Psoriasis ,Dermatology ,RL1-803 - Abstract
Abstract Psoriasis vulgaris is a systemic, chronic inflammatory disease affecting 2–3% of the population. Recent advances in the understanding of the pathophysiology of psoriatic disease have facilitated the development of novel therapeutic options with improved safety and efficacy. This article is coauthored by a patient with a lifelong history of psoriasis who experienced multiple treatment failures. He details his diagnosis and treatment experiences, as well as the physical, mental, and social ramifications of his skin condition. He then goes on to elaborate how evolutions in the treatment of psoriatic disease have impacted his life. This case is then discussed from the perspective of a dermatologist specializing in inflammatory skin disorders. We highlight the clinical features of psoriasis, its medical and psychosocial comorbidities, and the current landscape of psoriatic disease treatments.
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- 2023
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39. Sperm capacitation and transcripts levels are altered by in vitro THC exposure
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Vivien B. Truong, Ola S. Davis, Jade Gracey, Michael S. Neal, Jibran Y. Khokhar, and Laura A. Favetta
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Cannabis ,THC ,Sperm ,Capacitation ,Transcriptome ,Fertility ,Cytology ,QH573-671 - Abstract
Abstract Background Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally present in the male reproductive system. Since cannabis consumption is the highest among reproductive aged males, the current study aimed to further investigate the effects of THC exposure to phenotypical, physiological, and molecular parameters in sperm. Bull sperm of known fertility were used as a translational model for human sperm and subjected to in vitro treatment with physiologically relevant experimental doses of THC. Sperm parameters, capacitation, apoptosis, and transcript levels were evaluated following treatment. Results Motility, morphology, and viability of bovine sperm was unaltered from THC exposure. However, 0.32µM of THC caused an increased proportion of capacitating sperm (p
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- 2023
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40. Implemented Engagement Strategies as Interventions on School Aide Attendance
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Mark B. Kruzynski, Allison S. Davis, and Laurie K. LiPuma
- Abstract
School districts require many people to facilitate the education of students, making it important to put the right people in the right places and assure that those individuals are successful in fulfilling their job requirements. As Odden (2011) noted, education is people-intensive and schools have a need for talented people at all levels. In order to be successful in fulfilling their job requirements, school district employees, including non-teaching staff, need to be present at the worksite and perform the duties that were agreed to upon their hire. Murphy (2021) noted that districts have hundreds of low-paying positions they cannot fill, such as bus drivers, cafeteria workers, and classroom aides. Absences in schools are on the rise, as noted by Lieberman (2021), who stated, "staffing shortages that have been crushing schools for months--with frequent absences and unfilled openings for teachers, instructional aides, bus drivers, custodians, substitutes and more--are getting worse, not better, new survey results show." Porter and Steers (1973) noted that absenteeism has "potentially critical consequences for both the person and the organization" (p. 151). McClenney (1992) suggested in her study that an understanding of the relationship between attendance at teacher planning and principal meetings and other factors to absenteeism may provide important insight for employers who must cope with the consequences of employee absenteeism. Our study was conducted to explore a relationship between implemented engagement strategies for school aides and the potential for intervention on their attendance. Our findings suggest no relationship between including aides in teacher and principal meetings that discuss relevant student information about the students they support and the aides' attendance, at least at first. However, it was found that aides with more experience were more likely to volunteer for professional engagement opportunities. Additionally, aides at elementary levels were more likely to volunteer for professional engagement opportunities when compared to their secondary-level counterparts. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2022
41. Implemented Engagement Strategies as Interventions on School Aide Attendance
- Author
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Allison S. Davis, Mark B. Kruzynski, and Laurie K. LiPuma
- Abstract
School districts require many people to facilitate the education of students, making it important to put the right people in the right places and assure that those individuals are successful in fulfilling their job requirements. As Odden (2011) noted, education is people-intensive and schools have a need for talented people at all levels. In order to be successful in fulfilling their job requirements, school district employees, including non-teaching staff, need to be present at the worksite and perform the duties that were agreed to upon their hire. Murphy (2021) noted that districts have hundreds of low-paying positions they cannot fill, such as bus drivers, cafeteria workers, and classroom aides. Absences in schools are on the rise, as noted by Lieberman (2021), who stated, "staffing shortages that have been crushing schools for months--with frequent absences and unfilled openings for teachers, instructional aides, bus drivers, custodians, substitutes and more--are getting worse, not better, new survey results show." Porter and Steers (1973) noted that absenteeism has "potentially critical consequences for both the person and the organization" (p. 151). McClenney (1992) suggested in her study that an understanding of the relationship between attendance at teacher planning and principal meetings and other factors to absenteeism may provide important insight for employers who must cope with the consequences of employee absenteeism. Our study was conducted to explore a relationship between implemented engagement strategies for school aides and the potential for intervention on their attendance. Our findings suggest no relationship between including aides in teacher and principal meetings that discuss relevant student information about the students they support and the aides' attendance, at least at first. However, it was found that aides with more experience were more likely to volunteer for professional engagement opportunities. Additionally, aides at elementary levels were more likely to volunteer for professional engagement opportunities when compared to their secondary-level counterparts. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2022
42. Implemented Engagement Strategies as Interventions on School Aide Attendance
- Author
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Laurie K. LiPuma, Allison S. Davis, and Mark B. Kruzynski
- Abstract
School districts require many people to facilitate the education of students, making it important to put the right people in the right places and assure that those individuals are successful in fulfilling their job requirements. As Odden (2011) noted, education is people-intensive and schools have a need for talented people at all levels. In order to be successful in fulfilling their job requirements, school district employees, including non-teaching staff, need to be present at the worksite and perform the duties that were agreed to upon their hire. Murphy (2021) noted that districts have hundreds of low-paying positions they cannot fill, such as bus drivers, cafeteria workers, and classroom aides. Absences in schools are on the rise, as noted by Lieberman (2021), who stated, "staffing shortages that have been crushing schools for months--with frequent absences and unfilled openings for teachers, instructional aides, bus drivers, custodians, substitutes and more--are getting worse, not better, new survey results show." Porter and Steers (1973) noted that absenteeism has "potentially critical consequences for both the person and the organization" (p. 151). McClenney (1992) suggested in her study that an understanding of the relationship between attendance at teacher planning and principal meetings and other factors to absenteeism may provide important insight for employers who must cope with the consequences of employee absenteeism. Our study was conducted to explore a relationship between implemented engagement strategies for school aides and the potential for intervention on their attendance. Our findings suggest no relationship between including aides in teacher and principal meetings that discuss relevant student information about the students they support and the aides' attendance, at least at first. However, it was found that aides with more experience were more likely to volunteer for professional engagement opportunities. Additionally, aides at elementary levels were more likely to volunteer for professional engagement opportunities when compared to their secondary-level counterparts. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2022
43. Towards Transferable Adversarial Attacks on Image and Video Transformers.
- Author
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Zhipeng Wei, Jingjing Chen, Micah Goldblum, Zuxuan Wu, Tom Goldstein, Yu-Gang Jiang, and Larry S. Davis
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- 2023
- Full Text
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44. Teledermatology for skin cancer screening in rural Georgia utilizing teledermoscopy and distance learning: An ongoing report
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McKenzie E. Maloney, BS, Marisol Miranda-Galvis, DDS, MS, PhD, Brenda Santellano Juarez, MD, Kenza Mamouni, MBA, PhD, Lorriane Odhiambo, PhD, MPH, Samah Ibrahim, MBBS, K.M. Monirul Islam, PhD, Rhea-Beth Markowitz, PhD, Koosh Desai, MD, Harold Rabinovitz, MD, Kendall Buchanan, MD, Douglas Patten, MD, Loretta S. Davis, MD, and Jorge E. Cortes, MD
- Subjects
dermatology ,distance learning ,oncology ,skin cancer ,teledermoscopy ,teledermatology ,Dermatology ,RL1-803 - Published
- 2023
- Full Text
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45. Risk of COVID-19 after natural infection or vaccinationResearch in context
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Anne-Marie Rick, Matthew B. Laurens, Ying Huang, Chenchen Yu, Thomas C.S. Martin, Carina A. Rodriguez, Christina A. Rostad, Rebone M. Maboa, Lindsey R. Baden, Hana M. El Sahly, Beatriz Grinsztejn, Glenda E. Gray, Cynthia L. Gay, Peter B. Gilbert, Holly E. Janes, James G. Kublin, Yunda Huang, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M. Dunkle, Kathleen M. Neuzil, Lawrence Corey, Paul A. Goepfert, Stephen R. Walsh, Dean Follmann, Karen L. Kotloff, Atoya Adams, Eric Miller, Bruce G. Rankin, Steven Shinn, Marshall Nash, Sinikka L. Green, Colleen Jacobsen, Jayasree Krishnankutty, Sikhongi Phungwayo, Richard M. Glover, II, Stacy Slechta, Troy Holdeman, Robyn Hartvickson, Amber Grant, Terry L. Poling, Terry D. Klein, Thomas C. Klein, Tracy R. Klein, William B. Smith, Richard L. Gibson, Jennifer Winbigler, Elizabeth Parker, Priyantha N. Wijewardane, Eric Bravo, Jeffrey Thessing, Michelle Maxwell, Amanda Horn, Catherine Mary Healy, Christine Akamine, Laurence Chu, R. Michelle Chouteau, Michael J. Cotugno, George H. Bauer, Jr., Greg Hachigian, Masaru Oshita, Michael Cancilla, Kristen Kiersey, William Seger, Mohammed Antwi, Allison Green, Anthony Kim, Michael Desjardins, Jennifer A. Johnson, Amy Sherman, Judith Borger, Nafisa Saleem, Joel Solis, Martha Carmen Medina, Westly Keating, Edgar Garcia, Cynthia Bueno, Nathan Segall, Douglas S. Denham, Thomas Weiss, Ayoade Avworo, Parke Hedges, Cynthia Becher Strout, Rica Santiago, Yvonne Davis, Patty Howenstine, Alison Bondell, Kristin Marks, Tina Wang, Timothy Wilkin, Mary Vogler, Carrie Johnston, Michele P. Andrasik, Jessica G. Andriesen, Gail Broder, Niles Eaton, Huub G. Gelderblom, Rachael McClennen, Nelson Michael, Merlin Robb, Carrie Sopher, Vicki E. Miller, Fredric Santiago, Blanca Gomez, Insiya Valika, Amy Starr, Valeria D. Cantos, Sheetal Kandiah, Carlos del Rio, Nadine Rouphael, Srilatha Edupuganti, Evan J. Anderson, Andres Camacho-Gonzalez, Satoshi Kamidani, Meghan Teherani, David J. Diemert, Elissa Malkin, Marc Siegel, Afsoon Roberts, Gary Simon, Bindu Balani, Carolene Stephenson, Steven Sperber, Cristina Cicogna, Marcus J. Zervos, Paul Kilgore, Mayur Ramesh, Erica Herc, Kate Zenlea, Abram Burgher, Ann M. Milliken, Joseph D. Davis, Brendan Levy, Sandra Kelman, Matthew W. Doust, Denise Sample, Sandra Erickson, Shane G. Christensen, Christopher Matich, James Longe, John Witbeck, James T. Peterson, Alexander Clark, Gerald Kelty, Issac Pena-Renteria, Michael J. Koren, Darlene Bartilucci, Alpa Patel, Carolyn Tran, Christina Kennelly, Robert Brownlee, Jacob Coleman, Hala Webster, Carlos A. Fierro, Natalia Leistner, Amy Thompson, Celia Gonzalez, Lisa A. Jackson, Janice Suyehira, Milton Haber, Maria M. Regalado, Veronica Procasky, Alisha Lutat, Carl P. Griffin, Ripley R. Hollister, Jeremy Brown, Melody Ronk, Wayne L. Harper, Lisa Cohen, Lynn Eckert, Matthew Hong, Rambod Rouhbakhsh, Elizabeth Danford, John Johnson, Richard Calderone, Shishir K. Khetan, Oyebisi Olanrewaju, Nan Zhai, Kimberly Nieves, Allison O'Brien, Paul S. Bradley, Amanda Lilienthal, Jim Callis, Adam B. Brosz, Andrea Clement, Whitney West, Luke Friesen, Paul Cramer, Frank S. Eder, Ryan Little, Victoria Engler, Heather Rattenbury-Shaw, David J. Ensz, Allie Oplinger, Brandon J. Essink, Jay Meyer, Frederick Raiser, III, Kimberly Mueller, Keith W. Vrbicky, Charles Harper, Chelsie Nutsch, Wendell Lewis, III, Cathy Laflan, Jordan L. Whatley, Nicole Harrell, Amie Shannon, Crystal Rowell, Christopher Dedon, Mamodikoe Makhene, Gregory M. Gottschlich, Kate Harden, Melissa Gottschlich, Mary Smith, Richard Powell, Murray A. Kimmel, Simmy Pinto, Timothy P. Vachris, Mark Hutchens, Stephen Daniels, Margaret Wells, Mimi Van Der Leden, Peta-Gay Jackson-Booth, Mira Baron, Pamela Kane, Shannen Seversen, Mara Kryvicky, Julia Lord, Jamshid Saleh, Matthew Miles, Rafael Lupercio, John W. McGettigan, Jr., Walter Patton, Riemke Brakema, Karin Choquette, Jonlyn McGettigan, Judith L. Kirstein, Marcia Bernard, Mary Beth Manning, Joan Rothenberg, Toby Briskin, Denise Roadman, Sharita Tedder-Edwards, Howard I. Schwartz, Surisday Mederos, Shobha Swaminathan, Amesika Nyaku, Tilly Varughese, Michelle DallaPiazza, Sharon E. Frey, Irene Graham, Getahun Abate, Daniel Hoft, Leland N. Allen, III, Leslie A. Edwards, William S. Davis, Jr., Jessica M. Mena, Mark E. Kutner, Jorge Caso, Maria Hernandez Moran, Marianela Carvajal, Janet Mendez, Larkin T. Wadsworth, III, Michael R. Adams, Leslie Iverson, Joseph L. Newberg, Laura Pearlman, Paul J. Nugent, Michele D. Reynolds, Jennifer Bashour, Robert Schmidt, Neil P. Sheth, Kenneth Steil, Ramy J. Toma, William Kirby, Pink Folmar, Samantha Williams, Paul Pickrell, Stefanie Mott, Carol Ann Linebarger, Hussain Malbari, David Pampe, Veronica G. Fragoso, Lisa Holloway, Cecilia McKeown-Bragas, Teresa Becker, Barton G. Williams, William H. Jones, Jesse L. Clark, Steven Shoptaw, Michele Vertucci, Will Hernandez, Stephen A. Spector, Amaran Moodley, Jill Blumenthal, Lisa Stangl, Karen Deutsch, Kathleen M. Mullane, David Pitrak, Cheryl Nuss, Judy Pi, Carl Fichtenbaum, Margaret Powers-Fletcher, Michelle Saemann, Sharon Kohrs, Thomas B. Campbell, Andrew Lauria, Jose C. Mancilla, Hillary Dunlevy, Richard M. Novak, Andrea Wendrow, Scott Borgetti, Ben Ladner, Lisa Chrisley, Cheryl Young, Susanne Doblecki-Lewis, Maria L. Alcaide, Jose Gonzales-Zamora, Stephen Morris, David Wohl, Joseph Eron, Jr., Ian Frank, Debora Dunbar, David Metzger, Florence Momplaisir, Judith Martin, Alejandro Hoberman, Timothy Shope, Gysella Muniz, Richard Rupp, Amber Stanford, Megan Berman, Laura Porterfield, Michael Lewis, Elham Ghadishah, Joseph Yusin, Mai Pham, Clarence B. Creech, II, Shannon Walker, Stephanie Rolsma, Robert Samuels, Isaac Thomsen, Spyros A. Kalams, Greg Wilson, Gregg H. Lucksinger, Kevin Parks, Ryan Israelsen, Jaleh Ostovar, Kary Kelly, Jeffrey S. Overcash, Hanh Chu, Kia Lee, Luis I. De La Cruz, Steve Clemons, Elizabeth Everette, Suzanna Studdard, Gowdhami Mohan, Stefanie Tyson, Alyssa-Kay Peay, Danyel Johnson, Gregory J. Feldman, May-Yin Suen, Jacqueline Muenzner, Joseph Boscia, Farhan Siddiqui, John Sanders, James Peacock, Julio Nasim, Michael L. Levin, Julie Hussey, Marcy Kulic, Mark M. McKenzie, Teresa Deese, Erica Osmundsen, Christy Sweet, Valentine M. Ebuh, Elwaleed Elnagar, Georgette Ebuh, Genevieve Iwuala, Laurie J. Han-Conrad, Todd Simmons, Denis Tarakjian, Jeremy Ackermann, Mark S. Adams, José O. Alemán, Mohamed S. Al-Ibrahim, David R. Andes, Jeb Andrews, Roberto C. Arduino, Martín Bäcker, Diana Badillo, Emma Bainbridge, Teresa A. Batteiger, Jose A. Bazan, Roger J. Bedimo, Jorge A. Benitez, Annette R. Bennett, David I. Bernstein, Kristin Bialobok, Rebecca Boas, Judith Brady, Cynthia Brown, Catherine A. Bunce, Robert S. Call, Wesley Campbell, Ellie Carmody, Christopher Carpenter, Steven E. Carsons, Marvin Castellon, Mario Castro, Hannah Catan, Jennifer Chang, Mouna G. Chebib, Corey M. Chen, Margaret Cheng, Brian D.W. Chow, Annie Ciambruschini, Joseph P. Connor, James H. Conway, Maureen Cooney, Marcel Curlin, Claudia De La Matta Rodriguez, Jon F. Dedon, Emily Degan, Michelle Dickey, Craig Dietz, Jennifer L. Dong, Brenda Dorcely, Michael P. Dube, Carmel B. Dyer, Benjamin Eckhardt, Edward Ellerbeck, Evan C. Ewers, Amy Falk, Brittany Feijoo, Uriel R. Felsen, Tom Fiel, David Fitz-Patrick, Charles M. Fogarty, Stacy Ford, Lina M. Forero, Elizabeth Formentini, Doris Franco-Vitteri, Robert W. Frenck, Jr., Elie Gharib, Suzanne Gharib, Rola G. Rucker, James N. Goldenberg, Luis H. González, Brett Gray, Rusty Greene, Robert M. Grossberg, Juan V. Guanira-Carranza, Alfredo Gilberto Guerreros Benavides, Clint C. Guillory, Shauna H. Gunaratne, David Halpert, Holli Hamilton, William R. Hartman, Sheryl L. Henderson, Ramin Herati, Laura Hernandez Guarin, Robin Hilder, Ken Ho, Leila Hojat, Sybil G. Hosek, Jeffrey M. Jacobson, Melanie Jay, Diane H. Johnson, Kathleen S. Jones, Edward C. Jones-López, Jessica E. Justman, Scott Kahney, Lois Katz, Melinda Katz, Daniel Kaul, Michael C. Keefer, Ashley Kennedy, Jennifer Knishinsky, Laura Kogelman, Susan L. Koletar, Angelica Kottkamp, Maryrose Laguio-Vila, Raphael J. Landovitz, Jessica L. Lee, Albert Liu, Eneyda Giuvanela Llerena Zegarra, Anna S. Lok, James Lovell, Ronald Lubelchek, John Lucaj, Gary Luckasen, Annie Luetkemeyer, Njira Lucia Lugogo, Janine Maenza, Carlos Malvestutto, Monica Mauri, Ryan C. Maves, Kenneth H. Mayer, Michael J. McCartney, Margaret E. McCort, M. Juliana McElrath, Meredith McNairy, Fernando L. Merino, Eric A. Meyerowitz, Carol L. Mitchell, Cynthia L. Monaco, Sauda Muhammad, Sigridh Muñoz-Gómez, Sonal Munsiff, Paul Nee, Nicole L. Nollen, Asif Noor, Claudio Nuñez Lagos, Jason F. Okulicz, Patrick A. Oliver, Jessica Ortega, Steven Palmer, Lalitha Parameswaran, Purvi Parikh, Susan Parker, Reza Parungao, Juana R. Pavie, Rebecca P. Madan, Henry Peralta, Jennifer Petts, Kristen K. Pierce, E. Javier Pretell Alva, Lawrence J. Purpura, Vanessa Raabe, Sergio E. Recuenco, Tamara Richards, Sharon A. Riddler, Barbara Rizzardi, Rachel Rokser, Charlotte-Paige Rolle, Adam Rosen, Jeffrey Rosen, Lena R. Freese, María E. Santolaya, Linda M. Schipani, Adam Schwartz, Tiffany Schwasinger-Schmidt, Hyman Scott, Beverly E. Sha, Shivanjali Shankaran, Adrienne E. Shapiro, Stephan C. Sharp, Bo Shopsin, Matthew D. Sims, Stephanie Skipper, Derek M. Smith, Michael J. Smith, M. Mahdee Sobhanie, Brit Sovic, Stephanie Sterling, Robert Striker, Karla Beatriz Tafur Bances, Kawsar R. Talaat, Edward M. Tavel, Jr., Hong V. Tieu, Christian Tomaszewski, Ryan Tomlinson, Juan P. Torres, Julian A. Torres, John J. Treanor, Sade Tukuru, Robert J. Ulrich, Gregory C. Utz, Veronica Viar, Roberto A. Viau Colindres, Edward E. Walsh, Mary C. Walsh, Emmanuel B. Walter, Jessica L. Weidler, Yi H. Wu, Kinara S. Yang, Juan Luis Yrivarren Giorza, Arthur L. Zemanek, Kevin Zhang, Barry S. Zingman, Richard Gorman, Carmen A. Paez, Edith Swann, Simbarashe G. Takuva, Alex Greninger, Pavitra Roychoudhury, Robert W. Coombs, Keith R. Jerome, Flora Castellino, Xiaomi Tong, Corrina Pavetto, Teletha Gipson, Tina Tong, Marina Lee, James Zhou, Michael Fay, Kelly McQuarrie, Chimeremma Nnadi, Obiageli Sogbetun, Nina Ahmad, Ian De Proost, Cyrus Hoseyni, Paul Coplan, Najat Khan, Peter Ronco, Dawn Furey, Jodi Meck, Johan Vingerhoets, Boerries Brandenburg, Jerome Custers, Jenny Hendriks, Jarek Juraszek, Anne Marit de Groot, Griet Van Roey, Dirk Heerwegh, Ilse Van Dromme, Jorge F. Méndez Galván, Monica B. Carrascal, Adriana Sordo Duran, Laura Ruy Sanchez Guerrero, Martha Cecilia Gómora Madrid, Alejandro Quintín Barrat Hernández, Sharzhaad Molina Guizar, Denisse Alejandra González Estrada, Silvano Omar Martínez Pérez, Zindy Yazmín Zárate Hinojosa, Guillermo Miguel Ruiz-Palacios, Aurelio Cruz-Valdez, Janeth Pacheco-Flores, Anyela Lara, Secia Díaz-Miralrio, María José Reyes Fentanes, Jocelyn Zuleica Olmos Vega, Daniela Pineda Méndez, Karina Cano Martínez, Winniberg Stephany Alvarez León, Vida Veronica Ruiz Herrera, Eduardo Gabriel Vázquez Saldaña, Laura Julia Camacho Choza, Karen Sofia Vega Orozco, Sandra Janeth Ortega Domínguez, Jorge A. Chacón, Juan J. Rivera, Erika A. Cutz, Maricruz E. Ortegón, María I. Rivera, David Browder, Cortney Burch, Terri Moye, Paul Bondy, Lesley Browder, Rickey D. Manning, James W. Hurst, Rodney E. Sturgeon, Paul H. Wakefield, John A. Kirby, James Andersen, Szheckera Fearon, Rosa Negron, Amy Medina, John M. Hill, Vivek Rajasekhar, Hayes Williams, LaShondra Cade, Rhodna Fouts, Connie Moya, Corey G. Anderson, Naomi Devine, James Ramsey, Ashley Perez, David Tatelbaum, Michael Jacobs, Kathleen Menasche, Vincent Mirkil, Peter J. Winkle, Amina Z. Haggag, Michelle Haynes, Marysol Villegas, Sabina Raja, Robert Riesenberg, Stanford Plavin, Mark Lerman, Leana Woodside, Maria Johnson, C. Mary Healy, Jennifer A. Whitaker, Wendy A. Keitel, Robert L. Atmar, Gary Horwith, Robin Mason, Lisa Johnson, Tambra Dora, Deborah Murray, Logan Ledbetter, Beverly Ewing, Kathryn E. Stephenson, Chen S. Tan, Rebecca Zash, Jessica L. Ansel, Kate Jaegle, Caitlin J. Guiney, Jeffrey A. Henderson, Marcia O'Leary, Kendra Enright, Jill Kessler, Pete Ducheneaux, Asha Inniss, Donald M. Brandon, William B. Davis, Daniel T. Lawler, Yaa D. Oppong, Ryan P. Starr, Scott N. Syndergaard, Rozeli Shelly, Mashrur Islam Majumder, Danny Sugimoto, Jeffrey Dugas, Sr., Dolores Rijos, Sandra Shelton, Stephan Hong, Howard Schwartz, Nelia Sanchez-Crespo, Jennifer Schwartz, Terry Piedra, Barbara Corral, Carmen Medina, Michael E. Dever, Mitul Shah, Michael Delgado, Tameika Scott, Lisa S. Usdan, Lora J. McGill, Valerie K. Arnold, Carolyn Scatamacchia, Codi M. Anthony, Rajan Merchant, Anelgine C. Yoon, Janet Hill, Lucy Ng-Price, Teri Thompson-Seim, Ronald Ackerman, Jamie Ackerman, Florida Aristy, Nzeera Ketter, Jon Finley, Mildred Stull, Monica Murray, Zainab Rizvi, Sonia Guerrero, Yogesh K. Paliwal, Amit Paliwal, Sarah Gordon, Bryan Gordon, Cynthia Montano-Pereira, Christopher Galloway, Candice Montros, Lily Aleman, Samira Shairi, Wesley Van Ever, George H. Freeman, Esther L. Harmon, Marshall A. Cross, Kacie Sales, Catherine Q. Gular, Matthew Hepburn, Nathan Alderson, Shana Harshell, Siham Mahgoub, Celia Maxwell, Thomas Mellman, Karl M. Thompson, Glenn Wortman, Jeff Kingsley, April Pixler, LaKondria Curry, Sarah Afework, Austin Swanson, Jeffry Jacqmein, Maggie Bowers, Dawn Robison, Victoria Mosteller, Janet Garvey, Mary Easley, Rebecca J. Kurnat, Raymond Cornelison, Shanda Gower, William Schnitz, Destiny S. Heinzig-Cartwright, Derek Lewis, Fred E. Newton, Aeiress Duhart, Breanz Watkins, Brandy Ball, Jill York, Shelby Pickle, David B. Musante, William P. Silver, Linda R. Belhorn, Nicholas A. Viens, David Dellaero, Priti Patel, Kendra Lisec, Beth Safirstein, Luz Zapata, Lazaro Gonzalez, Evelyn Quevedo, Farah Irani, Joseph Grillo, Amy Potts, Julie White, Patrick Flume, Gary Headden, Brandie Taylor, Ashley Warden, Amy Chamberlain, Robert Jeanfreau, Susan Jeanfreau, Paul G. Matherne, Amy Caldwell, Jessica Stahl, Mandy Vowell, Lauren Newhouse, Vladimir Berthaud, Zudi-Mwak Takizala, Genevieve Beninati, Kimberly Snell, Sherrie Baker, James Walker, Tavane Harrison, Meagan Miller, Janet Otto, Roni Gray, Christine Wilson, Tiffany Nemecek, Hannah Harrington, Sally Eppenbach, Wendell Lewis, Tana Bourgeois, Lyndsea Folsom, Gregory Holt, Mehdi Mirsaeidi, Rafael Calderon, Paola Lichtenberger, Jalima Quintero, Becky Martinez, Lilly Immergluck, Erica Johnson, Austin Chan, Norberto Fas, LaTeshia Thomas-Seaton, Saadia Khizer, Jonathan Staben, Tatiana Beresnev, Maryam Jahromi, Mary A. Marovich, Julia Hutter, Martha Nason, Julie Ledgerwood, John Mascola, Mark Leibowitz, Fernanda Morales, Mike Delgado, Rosario Sanchez, Norma Vega, Germán Áñez, Gary Albert, Erin Coston, Chinar Desai, Haoua Dunbar, Mark Eickhoff, Jenina Garcia, Margaret Kautz, Angela Lee, Maggie Lewis, Alice McGarry, Irene McKnight, Joy Nelson, Patrick Newingham, Patty Price-Abbott, Patty Reed, Diana Vegas, Bethanie Wilkinson, Katherine Smith, Wayne Woo, Iksung Cho, Gregory M. Glenn, Filip Dubovsky, David L. Fried, Lynne A. Haughey, Ariana C. Stanton, Lisa Stevens Rameaka, David Rosenberg, Lee Tomatsu, Viviana Gonzalez, Millie Manalo, Bernard Grunstra, Donald Quinn, Phillip Claybrook, Shelby Olds, Amy Dye, Kevin D. Cannon, Mesha M. Chadwick, Bailey Jordan, Morgan Hussey, Hannah Nevarez, Colleen F. Kelley, Michael Chung, Caitlin Moran, Paulina Rebolledo, Christina Bacher, Elizabeth Barranco-Santana, Jessica Rodriguez, Rafael Mendoza, Karen Ruperto, Odette Olivieri, Enrique Ocaña, Paul E. Wylie, Renea Henderson, Natasa Jenson, Fan Yang, Amy Kelley, Kenneth Finkelstein, David Beckmann, Tanya Hutchins, Sebastian Garcia Escallon, Kristen Johnson, Teresa S. Sligh, Parul Desai, Vincent Huynh, Carlos Lopez, Erika Mendoza, Jeffrey Adelglass, Jerome G. Naifeh, Kristine J. Kucera, Waseem Chughtai, Shireen H. Jaffer, Matthew G. Davis, Jennifer Foley, Michelle L. Burgett, Tammi L. Shlotzhauer, Sarah M. Ingalsbe-Geno, Daniel Duncanson, Kelly Kush, Lori Nesbitt, Cora Sonnier, Jennifer McCarter, Michael B. Butcher, James Fry, Donna Percy, Karen Freudemann, Bruce C. Gebhardt, Padma N. Mangu, Debra B. Schroeck, Rajesh K. Davit, Gayle D. Hennekes, Benjamin J. Luft, Melissa Carr, Sharon Nachman, Alison Pellecchia, Candace Smith, Bruno Valenti, Maria I. Bermudez, Noris Peraita, Ernesto Delgado, Alicia Arrazcaeta, Natalie Ramirez, Carmen Amador, Horacio Marafioti, Lyly Dang, Lauren Clement, Jennifer Berry, Mohammed Allaw, Georgettea Geuss, Chelsea Miles, Zachary Bittner, Melody Werne, Cornell Calinescu, Shannon Rodman, Joshua Rindt, Erin Cooksey, Kristina Harrison, Deanna Cooper, Manisha Horton, Amanda Philyaw, William Jennings, Hilario Alvarado, Michele Baka, Malina Regalado, Linda Murray, Sherif Naguib, Justin Singletary, Sha-Wanda Richmond, Sarah Omodele, Emily Oppenheim, Reuben Martinez, Victoria Andriulis, Leonard Singer, Jeanne Blevins, Meagan Thomas, Christine Hull, Isabel Pereira, Gina Rivero, Tracy Okonya, Frances Downing, Paulina Miller, Margaret Rhee, Katherine Stapleton, Jeffrey Klein, Rosamond Hong, Suzanne Swan, Tami Wahlin, Elizabeth Bennett, Amy Salzl, Sharine Phan, Jewel J. White, Amanda Occhino, Ruth Paiano, Morgan McLaughlin, Elisa Swieboda, Veronica Garcia-Fragoso, Maria G. Becerra, Toni White, Christine B. Turley, Andrew McWilliams, Tiffany Esinhart, Natasha Montoya, Shamika Huskey, Leena Paul, Karen Tashima, Jennie Johnson, Marguerite Neill, Martha Sanchez, Natasha Rybak, Maria Mileno, Stuart H. Cohen, Monica Ruiz, Dean M. Boswell, Elizabeth E. Robison, Trina L. Reynolds, Sonja Neumeister, Carmen D. Zorrilla, Juana Rivera, Jessica Ibarra, Iris García, Dianca Sierra, Wanda Ramon, Suzanne Fiorillo, Rebecca Pitotti, Victoria R. Anderson, Jose Castillo Mancilla, Nga Le, Patricia L. Winokur, Dilek Ince, Theresa Hegmann, Jeffrey Meier, Jack Stapleton, Laura Stulken, Monica McArthur, Andrea Berry, Milagritos Tapia, Elizabeth Hammershaimb, Toni Robinson, Rosa MacBryde, Susan Kline, Joanne L. Billings, Winston Cavert, Les B. Forgosh, Timothy W. Schacker, Tyler D. Bold, Dima Dandachi, Taylor Nelson, Andres Bran, Grant Geiger, S. Hasan Naqvi, Diana F. Florescu, Richard Starlin, David Kline, Andrea Zimmer, Anum Abbas, Natasha Wilson, Joseph J. Eron, Michael Sciaudone, A. Lina Rosengren, John S. Kizer, Sarah E. Rutstein, Elizabeth Bruce, Claudia Espinosa, Lisa J. Sanders, Kami Kim, Denise Casey, Barbara S. Taylor, Thomas Patterson, Ruth S. Pinilla, Delia Bullock, Philip Ponce, Jan Patterson, R. Scott McClelland, Dakotah C. Lane, Anna Wald, Frank James, Elizabeth Duke, Kirsten Hauge, Jessica Heimonen, Erin A. Goecker, Youyi Fong, Carol Kauffman, Kathleen Linder, Kimberly Nofz, Andrew McConnell, Robert J. Buynak, Angella Webb, Taryn Petty, Stephanie Andree, Erica Sanchez, Nolan Mackey, Clarisse Baudelaire, Sarah Dzigiel, Adrienna Marquez, Kim Quillin, Michelle King, Vanessa Abad, Jennifer Knowles, Michael Waters, Karla Zepeda, Jordan Coslet, Dalia Tovar, Marian E. Shaw, Mark A. Turner, Cory J. Huffine, Esther S. Huffine, Julie A. Ake, Elizabeth Secord, Eric McGrath, Phillip Levy, Brittany Stewart, Charnell Cromer, Ayanna Walters, Grant Ellsworth, Caroline Greene, Sarah Galloway, Shashi Kapadia, Elliot DeHaan, Clint Wilson, Jason Milligan, Danielle Raley, Joseph Bocchini, Bruce McClenathan, Mary Hussain, Evelyn Lomasney, Evelyn Hall, Sherry Lamberth, Christy Schmeck, Vickie Leathers, Deborah A. Theodore, Angela R. Branche, Daniel S. Graciaa, Timothy J. Hatlen, Jacqueline Miller, Jerald Sadoff, Ann R. Falsey, and Magdalena E. Sobieszczyk
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COVID-19 ,Natural infection ,Hybrid immunity ,Vaccination ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health.
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- 2023
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46. Mechanisms of angioregression of the corpus luteum
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Corrine F. Monaco and John S. Davis
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corpus luteum ,angioregression ,endothelial cells ,PGF2α ,luteolysis ,ovary ,Physiology ,QP1-981 - Abstract
The corpus luteum is a transient ovarian endocrine gland that produces the progesterone necessary for the establishment and maintenance of pregnancy. The formation and function of this gland involves angiogenesis, establishing the tissue with a robust blood flow and vast microvasculature required to support production of progesterone. Every steroidogenic cell within the corpus luteum is in direct contact with a capillary, and disruption of angiogenesis impairs luteal development and function. At the end of a reproductive cycle, the corpus luteum ceases progesterone production and undergoes rapid structural regression into a nonfunctional corpus albicans in a process initiated and exacerbated by the luteolysin prostaglandin F2α (PGF2α). Structural regression is accompanied by complete regression of the luteal microvasculature in which endothelial cells die and are sloughed off into capillaries and lymphatic vessels. During luteal regression, changes in nitric oxide transiently increase blood flow, followed by a reduction in blood flow and progesterone secretion. Early luteal regression is marked by an increased production of cytokines and chemokines and influx of immune cells. Microvascular endothelial cells are sensitive to released factors during luteolysis, including thrombospondin, endothelin, and cytokines like tumor necrosis factor alpha (TNF) and transforming growth factor β 1 (TGFB1). Although PGF2α is known to be a vasoconstrictor, endothelial cells do not express receptors for PGF2α, therefore it is believed that the angioregression occurring during luteolysis is mediated by factors downstream of PGF2α signaling. Yet, the exact mechanisms responsible for angioregression in the corpus luteum remain unknown. This review describes the current knowledge on angioregression of the corpus luteum and the roles of vasoactive factors released during luteolysis on luteal vasculature and endothelial cells of the microvasculature.
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- 2023
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47. FCRL1 immunoregulation in B cell development and malignancy
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Murali K. Mamidi, Jifeng Huang, Kazuhito Honjo, Ran Li, Edlue M. Tabengwa, Indira Neeli, Nar’asha L. Randall, Manasa V. Ponnuchetty, Marko Radic, Chuen-Miin Leu, and Randall S. Davis
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FCRL1 ,B cells ,lymphocyte development ,B cell receptor ,signaling ,malignancy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Immunotherapeutic targeting of surface regulatory proteins and pharmacologic inhibition of critical signaling pathways has dramatically shifted our approach to the care of individuals with B cell malignancies. This evolution in therapy reflects the central role of the B cell receptor (BCR) signaling complex and its co-receptors in the pathogenesis of B lineage leukemias and lymphomas. Members of the Fc receptor-like gene family (FCRL1-6) encode cell surface receptors with complex tyrosine-based regulation that are preferentially expressed by B cells. Among them, FCRL1 expression peaks on naïve and memory B cells and is unique in terms of its intracellular co-activation potential. Recent studies in human and mouse models indicate that FCRL1 contributes to the formation of the BCR signalosome, modulates B cell signaling, and promotes humoral responses. Progress in understanding its regulatory properties, along with evidence for its over-expression by mature B cell leukemias and lymphomas, collectively imply important yet unmet opportunities for FCRL1 in B cell development and transformation. Here we review recent advances in FCRL1 biology and highlight its emerging significance as a promising biomarker and therapeutic target in B cell lymphoproliferative disorders.
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- 2023
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48. Development of SkinTracker, an integrated dermatology mobile app and web portal enabling remote clinical research studies
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Joy Q. Jin, Julie Hong, Kareem G. Elhage, Mitchell Braun, Riley K. Spencer, Mimi Chung, Samuel Yeroushalmi, Edward Hadeler, Megan Mosca, Erin Bartholomew, Marwa Hakimi, Mitchell S. Davis, Quinn Thibodeaux, David Wu, Abhilash Kahlon, Paul Dhaliwal, Erin F. Mathes, Navdeep Dhaliwal, Tina Bhutani, and Wilson Liao
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atopic dermatitis ,biometric data acquisition ,clinical research study ,eczema ,inflammatory skin disease ,mobile application ,Medicine ,Public aspects of medicine ,RA1-1270 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
IntroductionIn-person dermatology clinical research studies often face recruitment and participation challenges due to travel-, time-, and cost-associated barriers. Studies incorporating virtual/asynchronous formats can potentially enhance research subject participation and satisfaction, but few mobile health tools are available to enable remote study conduct. We developed SkinTracker, a patient-facing mobile app and researcher-facing web platform, that enables longitudinal collection of skin photos, patient reported outcomes, and biometric health and environmental data.MethodsEight design thinking sessions including dermatologists, clinical research staff, software engineers, and graphic designers were held to create the components of SkinTracker. Following iterative prototyping, SkinTracker was piloted across six adult and four pediatric subjects with atopic dermatitis (AD) of varying severity levels to test and provide feedback on SkinTracker for six months.ResultsThe SkinTracker app enables collection of informed consent for study participation, baseline medical history, standardized skin photographs, patient-reported outcomes (e.g., Patient Oriented Eczema Measure (POEM), Pruritus Numerical Rating Scale (NRS), Dermatology Life Quality Index (DLQI)), medication use, adverse events, voice diary to document qualitative experiences, chat function for communication with research team, environmental and biometric data such as exercise and sleep metrics through integration with an Apple Watch. The researcher web portal allows for management and visualization of subject enrollment, skin photographs for examination and severity scoring, survey completion, and other patient modules. The pilot study requested that subjects complete surveys and photographs on a weekly to monthly basis via the SkinTracker app. Afterwards, participants rated their experience in a 7-item user experience survey covering app function, design, and desire for participation in future studies using SkinTracker. Almost all subjects agreed or strongly agreed that SkinTracker enabled more convenient participation in skin research studies compared to an in-person format.DiscussionTo our knowledge, SkinTracker is one of the first integrated app- and web-based platforms allowing collection and management of data commonly obtained in clinical research studies. SkinTracker enables detailed, frequent capture of data that may better reflect the fluctuating course of conditions such as AD, and can be modularly customized for different skin conditions to improve dermatologic research participation and patient access.
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- 2023
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49. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture
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Cih Cheng, Naomi Deneke, Hye-ran Moon, Sae Rome Choi, Natalia Ospina-Muñoz, Bennett D. Elzey, Chelsea S. Davis, George T.-C Chiu, and Bumsoo Han
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Tumoroids ,Cancer-associated fibroblasts ,Cell-derived contraction ,Interpenetrating polymer network ,3D printing ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Recent advances in biomaterials and 3D printing/culture methods enable various tissue-engineered tumor models. However, it is still challenging to achieve native tumor-like characteristics due to lower cell density than native tissues and prolonged culture duration for maturation. Here, we report a new method to create tumoroids with a mechanically active tumor-stroma interface at extremely high cell density. This method, named “inkjet-printed morphogenesis” (iPM) of the tumor-stroma interface, is based on a hypothesis that cellular contractile force can significantly remodel the cell-laden polymer matrix to form densely-packed tissue-like constructs. Thus, differential cell-derived compaction of tumor cells and cancer-associated fibroblasts (CAFs) can be used to build a mechanically active tumor-stroma interface. In this methods, two kinds of bioinks are prepared, in which tumor cells and CAFs are suspended respectively in the mixture of collagen and poly (N-isopropyl acrylamide-co-methyl methacrylate) solution. These two cellular inks are inkjet-printed in multi-line or multi-layer patterns. As a result of cell-derived compaction, the resulting structure forms tumoroids with mechanically active tumor-stroma interface at extremely high cell density. We further test our working hypothesis that the morphogenesis can be controlled by manipulating the force balance between cellular contractile force and matrix stiffness. Furthermore, this new concept of “morphogenetic printing” is demonstrated to create more complex structures beyond current 3D bioprinting techniques.
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- 2023
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50. Evaluating the Archaeological Efficacy of Bathymetric LiDAR across Oceanographic Contexts: A Case Study from Apalachee Bay, Florida
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Jessica W. Cook Hale, Dylan S. Davis, and Matthew C. Sanger
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bathymetric LiDAR ,Florida ,shell middens ,underwater archaeology ,submerged landscapes ,sea level rise ,Archaeology ,CC1-960 - Abstract
This study presents preliminary results from recent bathymetric LiDAR-guided surveys of submerged archaeological landscapes in the Apalachee Bay off the coast of Florida. We show how bathymetric LiDAR can re-identify previously recorded archaeological sites and identify new cultural deposits at shallow depths and help aid SCUBA surveys of submerged environments. While most prior archaeological applications of bathymetric LiDAR have focused on shipwrecks and historic era sites, our case study demonstrates that bathymetric LiDAR is capable of detecting Holocene and Pleistocene era archaeological sites as well. Detecting and eventually characterizing these ancient deposits will greatly expand our understanding of settlement trends when sea levels were lower and may provide insights into how some of the earliest coastal populations adapted to this novel and changing environment. Our SCUBA surveys also elucidate the impact of local environmental conditions of the applicability of deploying bathymetric LiDAR; specifically, eel grass cover does not hinder LiDAR capabilities, while high rates of sedimentation greatly reduce success in identifying archaeological deposits. Overall, our results show promise in the future of applying remote sensing to study shallow submerged archaeological landscapes, which can help improve our understanding of human–environment dynamics prior to and during periods of sea level change.
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- 2023
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