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Sperm capacitation and transcripts levels are altered by in vitro THC exposure
- Source :
- BMC Molecular and Cell Biology, Vol 24, Iss 1, Pp 1-13 (2023)
- Publication Year :
- 2023
- Publisher :
- BMC, 2023.
-
Abstract
- Abstract Background Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally present in the male reproductive system. Since cannabis consumption is the highest among reproductive aged males, the current study aimed to further investigate the effects of THC exposure to phenotypical, physiological, and molecular parameters in sperm. Bull sperm of known fertility were used as a translational model for human sperm and subjected to in vitro treatment with physiologically relevant experimental doses of THC. Sperm parameters, capacitation, apoptosis, and transcript levels were evaluated following treatment. Results Motility, morphology, and viability of bovine sperm was unaltered from THC exposure. However, 0.32µM of THC caused an increased proportion of capacitating sperm (p
- Subjects :
- Cannabis
THC
Sperm
Capacitation
Transcriptome
Fertility
Cytology
QH573-671
Subjects
Details
- Language :
- English
- ISSN :
- 26618850
- Volume :
- 24
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Molecular and Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1f748eb905f24884a9e9b486ca49e96b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12860-023-00468-3