Search

Your search keyword '"Sánchez-Cortés, Juan"' showing total 7 results
Start Over Author "Sánchez-Cortés, Juan"
7 results on '"Sánchez-Cortés, Juan"'

1. Comunidades de aprendizaje Integración de la lectura crítica y la producción textual, una apuesta pedagógica de la Institución Educativa La Primavera, de Bello

Author

Pineda Mazo, Mónica Patricia, Sánchez Cortés, Juan Fredy, Orrego Ramírez, Jorge Humberto, and Parra Bernal, Lina Rosa

Subjects
Métodos de aprendizaje, Pedagogía, Lectoescritura
Abstract

Tesis de Maestría (Magíster en Pedagogía). Universidad Católica de Manizales. Facultad de Educación, 2020 Según estudios en Latinoamérica y publicados por la CEPAL(comisión Económica para América Latina), estos dan cuenta del diagnóstico generalizado sobre una debilidad en el sistema educativo colombiano y tiene que ver directamente con la ausencia de pensamiento crítico como consecuencia de la falta de lectura comprensiva y crítica, especialmente en los estudiantes de los niveles de primaria y de secundaria, siendo esto un factor determinante en el bajo rendimiento académico.( El Tercer Estudio Regional Comparativo y Explicativo TERCE) Realizado entre 2010 y 2014 para América Latina.

Published
2020

2. Cell Adhesion to Unnatural Ligands Mediated by a Bifunctional Protein

Author

Sánchez-Cortés, Juan, Bähr, Katinka, and Mrksich, Milan

Abstract

This paper describes a molecular strategy to restore adhesion of cells to surfaces that otherwise do not present ligands that can mediate adhesion. The approach is based on a carbonic anhydrase fusion protein that binds benzenesulfonamides and that also includes the RGD peptide motif that can bind to cell-surface integrin adhesion receptors. In this way, the fusion protein can bind to a monolayer that presents the benzenesulfonamide ligand, thereby positioning the RGD peptide at the surface, where it can mediate the adhesion and spreading of cells. This strategy may provide a general method for promoting the adhesion of cells to non-natural surfaces or to defective biological matrices.

Published
2024
Full Text
View/download PDF

3. Illegal gold, criminal alternative

Author

Sánchez Cortés, Juan Camilo, Vanegas Sánchez, Wendy Paola, and Gómez Azuero, Juan Pablo

Subjects
INDUSTRIA DEL ORO - ASPECTOS SOCIALES, guerrillas, poverty, pobreza, conflict, contaminación, corruption, oro, strategic resources, minería criminal, guerra, gold, corrupción, drugs, MINAS DE ORO, criminal gangs, drogas, pollution, war, bandas criminales, INDUSTRIA DEL ORO, criminal mining, conflicto, recursos estratègicos
Abstract

La presente monografía de grado tiene por objetivo comprender y analizar la realidad de la minería criminal en el sector aurífero. El estudio plasmado en este trabajo busca no sólo diagnosticar la actualidad de la minería del oro llevada de forma ilegal, sino quiere además advertir los peligros que implican las problemáticas derivadas de la explotación ilícita del oro por parte de grupos armados al margen de la ley. This monograph has the objective of understand and analyze the reality criminal in the gold of mining sector Colombian. The study expressed in this paper seeks not only diagnose the actual situation of the gold mining carried illegally, also intended to alert the dangers involved in issues arising from the illegal exploitation of gold by armed groups. Pregrado

Published
2015

7. The platelet integrin alphaIIbbeta3 binds to the RGD and AGD motifs in fibrinogen.

Author

Sánchez-Cortés J and Mrksich M

Subjects
Amino Acid Sequence, Animals, Binding, Competitive, CHO Cells, Cell Adhesion, Cricetinae, Cricetulus, Fibrinolytic Agents chemistry, Fibrinolytic Agents pharmacology, Humans, Protein Binding, Protein Interaction Domains and Motifs, Fibrinogen metabolism, Oligopeptides metabolism, Platelet Glycoprotein GPIIb-IIIa Complex metabolism
Abstract

Fibrinogen (Fbg) mediates platelet aggregation by binding the alphaIIbbeta3 integrin receptor, but the interaction of the receptor with peptide motifs of Fbg remains unresolved. This paper describes the use of self-assembled monolayers (SAMs) to study the adhesion of alphaIIbbeta3-transfected CHO cells to the GRGDS and HHLGGAKQAGDV motifs within Fbg. Cells adhered to and spread on monolayers presenting either peptide. Cell adhesion could be inhibited by either soluble peptide, demonstrating that the peptides bind competitively to the integrin. A peptide array was used to show that AGD was the minimal binding sequence in HHLGGAKQAGDV and that the receptor recognizes ligands of the form GXGDSC, where X is a hydrophobic or basic residue. This work revises our understanding of the alphaIIbbeta3 specificity and also suggests a new class of antithrombotic agents.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results