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1. Supra-ceramics: a molecule-driven frontier of inorganic materials

Author

Kazuhiko Maeda, Teruki Motohashi, Ryo Ohtani, Kunihisa Sugimoto, Yuta Tsuji, Akihide Kuwabara, and Satoshi Horike

Subjects
Metal complexes, organic-inorganic hybrids, perovskites, metal-organic frameworks, coordination polymers, batteries, Materials of engineering and construction. Mechanics of materials, TA401-492, Biotechnology, TP248.13-248.65
Abstract

Discoveries and technological innovations over the past decade are transforming our understanding of the properties of ceramics, such as ‘hard’, ‘brittle’, and ‘homogeneous’. For example, inorganic crystals containing molecular anions exhibit excellent secondary battery characteristics, and the fusion of inorganic solids and molecules results in innovative catalytic functions and physical properties. Different from the conventional ceramics such as metal oxides that are formed by monatomic cations and anions, unique properties and functions can be expected in molecular-incorporated inorganic solids, due to the asymmetric and dynamic properties brought about by the constituent molecular units. We name the molecular-incorporated inorganic materials that produce innovative properties and functions as supra-ceramics. In this article, we describe various kinds of supra-ceramics from the viewpoint of synthesis, analysis and physical properties/functions for a wide range of applications.

Published
2024
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2. Exploration of glassy state in Prussian blue analogues

Author

Nattapol Ma, Ryo Ohtani, Hung M. Le, Søren S. Sørensen, Ryuta Ishikawa, Satoshi Kawata, Sareeya Bureekaew, Soracha Kosasang, Yoshiyuki Kawazoe, Koji Ohara, Morten M. Smedskjaer, and Satoshi Horike

Subjects
Science
Abstract

Developments in Prussian blue analogues (PBAs) have centred solely on their crystalline state. Here, the authors describe the preparation of the glassy state of PBAs via a mechanically induced crystal-to-glass transformation and explore their properties.

Published
2022
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3. Predictors of Cardioembolic Stroke in Japanese Patients with Atrial Fibrillation in the Fushimi AF Registry

Author

Ken Yasuda, Shunichi Fukuda, Michikazu Nakamura, Ryo Ohtani, Yasuhiro Kuwata, Masaki Takata, Makoto Sainouchi, Masahiro Gotou, Yuichi Masuda, Satoru Kawarazaki, Yasuhiro Kawabata, Nagako Murase, Tomokazu Aoki, Naohiro Yonemoto, Masaharu Akao, and Tetsuya Tsukahara

Subjects
Atrial fibrillation, Cardioembolic stroke, Risk factors, Stroke subtype, Infarct volume, Cohort study, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Large-scale clinical trials have analyzed risk factors for any ischemic stroke in patients with atrial fibrillation (AF). However, the risk factors for cardioembolic stroke (CES), specifically, have not been reported. To clarify the risk factors for CES and clinically significant cardioembolic infarction, we examined the incidence of CES and larger infarct volume (IV) (> 30 mL) CES, employing the Fushimi AF Registry, a community-based prospective cohort of AF patients in the Fushimi ward, Kyoto, Japan. Methods: A total of 4,182 Fushimi AF patients were enrolled from March 2011 to December 2014. The risk factors for CES were evaluated using multivariate analysis. Results: Of 4,182 patients enrolled, 3,749 patients were observed for ≥1 year. During the follow-up period (mean duration, 979 ± 7.7 days), 91/3,749 patients experienced a CES (2.43%). Significant risk factors associated with CES were older age (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.01–1.72; p = 0.046), low body weight (OR, 1.30; 95% CI, 1.03–1.65; p = 0.033), sustained AF (OR, 1.67; 95% CI, 1.05–2.71; p = 0.034), and previous stroke or transient ischemic attack (TIA) (OR, 1.94; 95% CI, 1.22–3.06; p = 0.004). Predictors of a large IV were chronic kidney disease (CKD) (OR, 2.08; 95% CI, 1.09–4.05; p = 0.027) and previous stroke/TIA (OR, 2.27; 95% CI, 1.19–4.24; p = 0.011). Conclusions: In this population-based cohort of Japanese patients with AF, in addition to previous stroke/TIA and older age, sustained AF and low body weight emerged as risk factors for CES, as opposed to any stroke, which may have a different risk profile. Patients with CKD or previous stroke/TIA who developed cardioembolic infarction exhibited more advanced severity. There is a need for direct oral anticoagulants that can be used safely in patients with comorbid AF and CKD.

Published
2018
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5. Crystal structure of [2-({2-[(2-azanidylbenzylidene)amino]benzylidene}amino)-4-chlorophenolato]nickel(II)

Author

Fumiya Kobayashi, Atsushi Koga, Ryo Ohtani, Shinya Hayami, and Masaaki Nakamura

Subjects
crystal structure, nickel(II) complex, 2-aminobenzaldehyde, asymmetric structure, supramolecular structure, Crystallography, QD901-999
Abstract

The title complex, [Ni(C20H14ClN3O)], with an asymmetrically chloride-appended Schiff base ligand has been synthesized and structurally characterized at 100 K. In the compound, the central nickel(II) ion has a square-planar coordination geometry with N3O donors of the π-conjugated tetradentate Schiff base ligand. In the crystal, the complexes are connected into an inversion dimer via an Ni...Ni interaction [3.1753 (5) Å] and a pair of π–π interactions [centroid–centroid distance = 3.8416 (16) Å]. The dimers are linked via a C—H...Cl hydrogen bond, forming a chain along the c-axis direction. The dimer chains interact with each other through π–π interactions [centroid–centroid distance = 3.8736 (16) Å], forming a layer expanding parallel to the ac plane.

Published
2017
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6. Development of an All Solid State Battery Incorporating Graphene Oxide as Proton Conductor

Author

Yuta Shudo, Md. Saidul Islam, Mohammad Razaul Karim, Nurun Nahar Rabin, Kosuke Wakata, Ryo Ohtani, Masaaki Nakamura, Leonard F. Lindoy, and Shinya Hayami

Subjects
graphene oxide, solid electrolyte, solid state battery, Technology, Environmental sciences, GE1-350
Abstract

Graphene oxide (GO) shows high proton conductivity (≈10−4 Scm−1), excellent mechanical stability, and electrical insulation property, which makes it an ideal candidate for use as a proton conducting solid state electrolyte. The prospects of using GO as single phase solid electrolyte in an all solid battery is presented herein. A battery with the cell configuration: Zn + ZnSO4•7H2O + graphite (anode) || GO (electrolyte) || MnO2 + graphite (cathode) is fabricated. Cyclic voltammetry confirms its rechargeable nature. The respective discharge capacity and power density of the cell are 360 μAh and 19.5 mW kg−1 at a constant current drain of 3 μA under the experimental conditions employed. GO based proton conductors are cleaner and cheaper than other solid electrolytes. The current study strongly suggests that GO can be used as a practical and beneficial component in solid state battery applications with low energy feedback.

Published
2017
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7. Crystal structure of bis[4′-(1,4,7,10-tetraoxa-13- azacyclopentadecan-13-yl)-2,2′:6′,2′′-terpyridine]cobalt(III) tris(perchlorate) methanol monosolvate monohydrate

Author

Hitomi Ohmagari, Manabu Nakaya, Ryo Ohtani, Masaaki Nakamura, and Shinya Hayami

Subjects
crystal structure, terpyridine, crown ether, hydrogen bonding, C—H...π interactions, π–π stacking interactions, Crystallography, QD901-999
Abstract

In the title compound, [Co(C25H30N4O4)2](ClO4)3·CH3OH·H2O, the metal atom is coordinated by two tridentate crown ether terpyridine ligands, forming a distorted CoN6 octahedron. The three pyridine rings in each crown–terpyridine ligand are approximately coplanar [maximum deviations = 0.088 (12) and 0.102 (15) Å] and the mean planes through the three pyridine rings are perpendicular to each other, making a dihedral angle of 89.95 (17)°. An intramolecular C—H...π interaction is observed between the two terpyridine ligands. In the crystal, O—H...O and C—H...O hydrogen bonds, a π–π stacking interaction [centroid–centroid distance = 3.923 (7) Å] and a C—H...π interaction connect the complex cation, the perchlorate anions and the two types of solvent molecules, forming a three-dimensional network.

Published
2015
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11. Different patterns of sensory nerve involvement in chronic inflammatory demyelinating polyneuropathy subtypes

Author

Kazumoto Shibuya, Atsuko Tsuneyama, Sonoko Misawa, Yo‐ichi Suzuki, Tomoki Suichi, Yuta Kojima, Keigo Nakamura, Hiroki Kano, Ryo Ohtani, Yuya Aotsuka, Marie Morooka, Mario Prado, and Satoshi Kuwabara

Subjects
Cellular and Molecular Neuroscience, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Sural Nerve, Physiology, Physiology (medical), Neural Conduction, Humans, Neurology (clinical), Ulnar Nerve, Median Nerve
Abstract

Among subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP), different immune pathophysiologies have been proposed. In this study, sensory nerve conduction studies were compared among clinical subtypes to attempt to better understand the underlying pathophysiology.A total of 138 patients with CIDP was classified into clinical subtypes: typical CIDP (N = 68), multifocal CIDP (N = 27), or other (N = 2). Patients with immunoglobulin M (IgM) neuropathy anti-myelin-associated glycoprotein neuropathy (MAG; N = 19) were also included as disease controls. Sensory nerve action potentials (SNAPs) were recorded in the median, ulnar, and superficial radial and sural nerves.SNAP amplitudes (P .05) and conduction velocities (P .01) in the median nerve and conduction velocities (P .05) in the ulnar nerve were lower in typical CIDP than in multifocal CIDP, whereas those in the radial and sural nerves were comparable in each group. Low median and normal sural SNAP amplitudes were more common in typical CIDP (P .005) than in multifocal CIDP, suggesting predominant involvement at terminal portions of the nerves.Terminal portions of sensory nerves are preferentially affected in typical CIDP compared with multifocal CIDP. These findings might be partially explained by the hypothesis of antibody-mediated demyelination in typical CIDP at the regions where the blood-nerve barrier is anatomically deficient, whereas multifocal CIDP predominantly affects the nerve trunks, largely due to cell-mediated demyelination, with disruption of the blood-nerve barrier.

Published
2022
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12. The ligand field in low-crystallinity metal–organic frameworks investigated by soft X-ray core-level absorption spectroscopy

Author

Kohei Yamagami, Haruka Yoshino, Hirona Yamagishi, Hiroyuki Setoyama, Arata Tanaka, Ryo Ohtani, Masaaki Ohba, and Hiroki Wadati

Subjects
General Physics and Astronomy, Physical and Theoretical Chemistry
Abstract

The ligand field (LF) of transition metal ions is a crucial factor in realizing the mechanism of novel physical and chemical properties. However, the low-crystallinity state, including the amorphous state, precludes the clarification of the electronic structural relationship of transition metal ions using crystallographic techniques, ultraviolet and infrared optical methods, and magnetometry. Here, we demonstrate that soft X-ray 2p → 3d core-level absorption spectroscopy (

Published
2022
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14. Flexibility Control of Two‐Dimensional Coordination Polymers by Crystal Morphology: Water Adsorption and Thermal Expansion

Author

Jenny Pirillo, Shinya Hayami, Hiroyoshi Ohtsu, Haruka Yoshino, Yuh Hijikata, Benjamin Le Ouay, Masaaki Ohba, Yuta Shudo, Masaaki Sadakiyo, Daisuke Hashizume, Kenichi Kato, Junichi Yanagisawa, and Ryo Ohtani

Subjects
chemistry.chemical_classification, Flexibility (anatomy), Chemistry, Organic Chemistry, Chemical modification, General Chemistry, Polymer, Catalysis, Thermal expansion, Adsorption, medicine.anatomical_structure, Chemical engineering, medicine, Molecule, Metal-organic framework, Layer (electronics)
Abstract

Layer flexibility in two-dimensional coordination polymers (2D-CPs) contributes to several functional materials as it results in anisotropic structural response to external stimuli. Chemical modification is a common technique for modifying layer structures. This study demonstrates that crystal morphology of a cyanide-bridged 2D-CP of type [Mn(salen)]2 [ReN(CN)4 ] (1) consisting of flexible undulating layers significantly impacts the layer configuration and assembly. Nanoplates of 1 showed an in-plane contraction of layers with a longer interlayer distance compared to the micrometer-sized rod-type particles. These effects by crystal morphology on the structure of the 2D-CP impacted the structural flexibility, resulting in dual-functional changes: the enhancement of the sensitivity of structural transformation to water adsorption and modification of anisotropic thermal expansion of 1. Moreover, the nanoplates incorporated new adsorption sites within the layers, resulting in the uptake of an additional water molecule compared to the micrometer-sized rods.

Published
2021
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15. Negative Thermal Expansion of Undulating Coordination Layers through Interlayer Interaction

Author

Ryo Ohtani, Junichi Yanagisawa, Yuudai Iwai, Benjamin Le Ouay, and Masaaki Ohba

Subjects
Inorganic Chemistry, Physical and Theoretical Chemistry
Abstract

The negative thermal expansion (NTE) of solid-state materials is of significance in various fields, but a very rare phenomenon. In this study, we carried out a meta-analysis for the anisotropic thermal expansion behavior of fifteen two-dimensional coordination polymers [M(salen)]

Published
2022

16. A Cyanido-bridged Luminescent Coordination Polymer Composed of Janus-type Layers and Its Two-dimensional Negative Thermal Expansion

Author

Benjamin Le Ouay, Ryo Ohtani, Jingo Kitano, Kenta Sasaki, Haruka Yoshino, and Masaaki Ohba

Subjects
chemistry.chemical_compound, Crystallography, Negative thermal expansion, Chemistry, Coordination polymer, General Chemistry, Janus, Luminescence, Layer (electronics), Thermal expansion
Abstract

A luminescent two-dimensional coordination polymer of type [Cd(H2O)(EtOH)][ReN(CN)4(H2O)]·2H2O (CdRe) incorporating “Janus-type” cyanido-bridged layers was synthesized. Within each layer of CdRe, t...

Published
2021
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17. Fabrication of HTS Low-Noise Nanobridge Josephson Junction by Gallium FIB

Author

Ryo Ohtani, Seiichiro Ariyoshi, Saburo Tanaka, Kanji Hayashi, and Teppei Ueda

Subjects
Josephson effect, Materials science, Fabrication, business.industry, chemistry.chemical_element, Substrate (electronics), Condensed Matter Physics, 01 natural sciences, Focused ion beam, Electronic, Optical and Magnetic Materials, Pulsed laser deposition, chemistry, 0103 physical sciences, Optoelectronics, Electrical and Electronic Engineering, Ion milling machine, Thin film, Gallium, 010306 general physics, business
Abstract

High-temperature superconductor (HTS) Josephson junctions (JJs) are primarily based on artificial grain boundaries. Bi-crystal JJs are typically utilized in HTS superconducting quantum interference devices (SQUIDs). However, the performances of bi-crystal JJs depend significantly on the quality of the interface at the junction. In this study, we investigate a method for forming nanobridge JJs via gallium focused ion beam (FIB) irradiation. A 100-nm-thick YBa2Cu3O7- δ was deposited on an MgO (100) substrate via pulsed laser deposition. An additional 20-nm-thick Au layer, which serves as a protection layer preventing ion damage during alignment, was deposited in situ. HTS microchannels with a width of 4 μm were defined via photolithography and argon ion milling. The HTS microchannel widths are decreased via FIB line scans to create nanobridges. The JJs are fabricated using two types of HTS thin films, in which one has a higher critical current density ( J C) that the other. The fabrication process using the gallium FIB was optimized and nanobridges with a junction width of 80 nm were prepared. As a result, a better with higher J C (5 MA/cm2) HTS films allowed for making junctions exhibiting up to five Shapiro steps at 77 K.

Published
2021
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18. Vapor-Induced Conversion of a Centrosymmetric Organic-Inorganic Hybrid Crystal into a Proton-Conducting Second-Harmonic-Generation-Active Material

Author

Junichi Yanagisawa, Kyosuke Tanaka, Hideaki Kano, Kiyoshi Miyata, Benjamin Le Ouay, Ryo Ohtani, and Masaaki Ohba

Subjects
Inorganic Chemistry, Physical and Theoretical Chemistry
Abstract

Chemical responsivity in materials is essential to build systems with switchable functionalities. However, polarity-switchable materials are still rare because inducing a symmetry breaking of the crystal structure by adsorbing chemical species is difficult. In this study, we demonstrate that a molecular organic-inorganic hybrid crystal of (NEt

Published
2022

19. Water-soluble Ionic Metal-Organic Polyhedra as a Versatile Platform for Enzyme Bio-immobilization

Author

Benjamin Le Ouay, Ryosuke Minami, Rin Kunitomo, Yuta Ohtsubo, Kohei Torikai, Ryo Ohtani, Clemence Sicard, and Masaaki Ohba

Abstract

Metal-organic polyhedra (MOPs) can act as elementary structural units for the design of modular porous materials; however, their association with biological systems remains greatly restricted by their typically low stabilities and solubilities in water. Hereby, we describe the preparation of novel MOPs bearing either anionic or cationic groups and exhibiting a high affinity for proteins. Simple mixing of protein (BSA) and ionic MOPs aqueous solutions resulted in the spontaneous formation of MOP-protein assemblies, in a colloidal state or as solid precipitates depending on the initial mixing ratio. The versatility of the method was further illustrated using two enzymes, catalase and cytochrome c, with different sizes and isoelectric points (pI) below and above 7. This mode of assembly led to the high retention of catalytic activity and enabled recyclability. Furthermore, the co-immobilization of cytochrome c with highly charged MOPs resulted in a substantial 44-fold increase of its catalytic activity.

Published
2022
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20. Metal Complex Lipids for Fluid–Fluid Phase Separation in Coassembled Phospholipid Membranes

Author

Masaaki Ohba, Koichi Kato, Hikaru Watanabe, Yuka Anegawa, Ryo Ohtani, Nobuaki Matsumori, Shinya Hayami, Masaaki Nakamura, Masanao Kinoshita, Yutaro Tajima, Saeko Yanaka, and Kenichi Kawano

Subjects
Phase transition, 010405 organic chemistry, Chemistry, Vesicle, Phospholipid, General Chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Metal, chemistry.chemical_compound, Membrane, Chemical engineering, visual_art, Phase (matter), Amphiphile, visual_art.visual_art_medium, Lipid bilayer
Abstract

We demonstrate a fluid-fluid phase separation in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) membranes using a metal complex lipid of type [Mn(L1)] (1; HL1 = 1-(2-hydroxybenzamide)-2-(2-hydroxy-3-formyl-5-hexadecyloxybenzylideneamino)ethane. Small amount of 1 produces two separated domains in DMPC, whose phase transition temperatures of lipids (Tc) are both lower than that of the pristine DMPC. Variable temperature fluorescent microscopy for giant-unilamellar vesicles of DMPC/1 hybrids demonstrates that visible phase separations remain in fluid phases up to 37 °C, which is clearly over the Tc of DMPC. This provides a new dimension for the application of metal complex lipids toward controlling lipid distributions in fluid membranes.

Published
2021
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21. Guest-Tunable Excited States in a Cyanide-Bridged Luminescent Coordination Polymer

Author

Kiyoshi Miyata, Masaaki Ohba, Hitomi Yamate, Kenta Sasaki, Haruka Yoshino, Benjamin Le Ouay, Ryo Ohtani, Ken Onda, Hiroki Miura, Kunihisa Sugimoto, Masaki Saigo, and Yuushi Shimoda

Subjects
Inorganic Chemistry, chemistry.chemical_compound, Chemistry, Coordination polymer, Excited state, Bathochromic shift, Luminophore, Infrared spectroscopy, Molecule, Physical and Theoretical Chemistry, Ground state, Luminescence, Photochemistry
Abstract

The excited-state energy was tuned successfully by guest molecules in a cyanide-bridged luminescent coordination polymer (CP). Methanol or ethanol vapor reversibly and significantly changed the luminescent color of the CP between green and yellow (Δλem = 32 nm). These vapors did not significantly affect the environment around the luminophore in the ground state of the CP, whereas they modulated the excited states for the resulting bathochromic shift. The time-resolved photoluminescent spectra of the CP systems showed that solvent adsorption enhanced the energetic relaxation in the excited states. Furthermore, time-resolved infrared spectroscopy indicated that cyanide bridging in the CP became more flexible in the excited states than that in the ground state, highlighting the sensitivity of the excited states to external stimuli, such as the guest vapor. Overall, guest-tunable excited states will allow the more straightforward design of sensing materials by characterizing the transient excited states.

Published
2021
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22. Coordination Geometry Changes in Amorphous Cyanide-Bridged Metal–Organic Frameworks upon Water Adsorption

Author

Akio Mishima, Haruka Yoshino, Ryo Ohtani, Kohei Yamagami, Benjamin Le Ouay, Hiroki Wadati, Hirona Yamagishi, Hiroyuki Setoyama, Sayuri Shimoda, and Masaaki Ohba

Subjects
010405 organic chemistry, Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Amorphous solid, Inorganic Chemistry, Metal, Bond length, Crystallography, Adsorption, Octahedron, visual_art, visual_art.visual_art_medium, Metal-organic framework, Physical and Theoretical Chemistry, Absorption (chemistry), Coordination geometry
Abstract

Amorphous coordination polymers and metal-organic frameworks (MOFs) have attracted much attention owing to their various functionalities. Here, we demonstrate the tunable water adsorption behavior of a series of amorphous cyanide-bridged MOFs with different metals (M[Ni(CN)4]: MNi; M = Mn, Fe, and Co). All three compounds adsorb up to six water molecules at a certain vapor pressure (Pads) and undergo conversion to crystalline Hofmann-type MOFs, M(H2O)2[Ni(CN)4]·4H2O (MNi-H2O; M = Mn, Fe, and Co). The Pads of MnNi, FeNi, and CoNi for water adsorption is P/P0 = 0.4, 0.6, and 0.9, respectively. Although the amorphous nature of these materials prevented structural elucidation using X-ray crystallography techniques, the local-scale structure around the N-coordinated M2+ centers was analyzed using L2,3-, K-edge X-ray absorption fine structure, and magnetic measurements. Upon hydration, the coordination geometry of these metal centers changed from tetrahedral to octahedral, resulting in significant reorganization of the MOF local structure. On the other hand, Ni[Ni(CN)4] (NiNi) containing square-planar Ni2+ centers did not undergo significant structural transformation and therefore abruptly adsorbed H2O in the low-pressure region. We could thus define how changes in the bond lengths and coordination geometry are related to the adsorption properties of amorphous MOF systems.

Published
2021
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23. Light-induced excited spin state trapping in iron(<scp>iii</scp>) complexes

Author

Leonard F. Lindoy, Manabu Nakaya, Shinya Hayami, and Ryo Ohtani

Subjects
Inorganic Chemistry, Materials science, Spin states, Chemical physics, Spin crossover, Excited state, Light induced, Trapping, Optical switch, LIESST
Abstract

Spin crossover in iron(II) and iron(III) complexes continues to receive much attention for the construction of molecular devices due to the presence of functionalities arising from their spin state switching behavior. Notably, some such compounds are associated with a light-induced excited spin-state trapping (LIESST) effect, which is responsible for the optical switching of their spin states. However, as opposed to iron(II) complexes, reports of iron(III) complexes that exhibit a LIESST effect are somewhat limited. This review presents an overview of the reported examples of SCO iron(III) systems that display LIESST effects.

Published
2021
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24. Guest-selective and reversible magnetic phase switching in a pseudo-pillared-layer porous magnet

Author

Narumi Tomokage, Benjamin Le Ouay, Hitoshi Miyasaka, Wataru Kosaka, Ryo Ohtani, Akio Mishima, Masaaki Ohba, and Haruka Yoshino

Subjects
Materials science, Metals and Alloys, Cationic polymerization, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Crystallography, Adsorption, Ferromagnetism, Magnet, Materials Chemistry, Ceramics and Composites, Antiferromagnetism, Molecule, Porosity, Layer (electronics)
Abstract

A novel porous magnet consisting of cationic two-dimensional (2-D) layers extended by FeIII–CN–NiII linkages and pseudo-pillar dianions was synthesized. The size-selective guest adsorption behaviour of water and methanol molecules originates from the narrow bottle-neck-type pores in the flexible pseudo-pillared-layer structure, which results in the switching of the magnetic phases from antiferromagnetic to ferromagnetic, involving significant changes in the interlayer distance.

Published
2021
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25. Theoretical investigation of tetrahedral distortion of four-coordinate iron(<scp>ii</scp>) centres in FePd(CN)4

Author

Akihide Kuwabara, Susumu Fujii, and Ryo Ohtani

Subjects
Inorganic Chemistry, Materials science, Atomic orbital, Distortion, Tetrahedron, Density of states, Electronic effect, Tetrahedral molecular geometry, Molecular physics
Abstract

The tetrahedral distortion of iron(II) centres in the cyanide-bridged framework FePd(CN)4 was recently demonstrated experimentally. Here, we theoretically confirmed the electronically driven tetrahedral distortion of iron(II) by comparing the density of states and total energies of FePd(CN)4 (d6) and ZnPd(CN)4 (d10). The calculation results suggested that a Jahn–Teller-like effect is caused on the tetrahedral geometry by the electronic effect of unequally occupied non-bonding 3d orbitals in the corresponding structure.

Published
2021
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26. Spin crossover phenomena in long chain alkylated complexes

Author

Leonard F. Lindoy, Shinya Hayami, Ryo Ohtani, and Ryohei Akiyoshi

Subjects
chemistry.chemical_classification, Materials science, Astrophysics::High Energy Astrophysical Phenomena, Polymer, Alkylation, Condensed Matter::Soft Condensed Matter, Inorganic Chemistry, Metal, Colloid, Chain (algebraic topology), chemistry, Chemical physics, Liquid crystal, Spin crossover, visual_art, visual_art.visual_art_medium, Alkyl
Abstract

Soft materials represented by polymers, liquid crystals, and colloids are a class of materials that exhibit a variety of unique functionalities which derive from their non-rigid structures. In particular, soft metal complexes incorporating flexible long alkyl chains in their structures have been shown to display synergy between the structural dynamics of the long alkyl chain moieties and the electron dynamics occurring at the metal centre. This review presents a discussion of such soft metal complexes with a focus on spin crossover (SCO) behaviours that are associated with a structural phase transition, including a liquid crystal (LC) transition, arising from the flexible natures of the respective complexes. We also discuss how to fabricate soft materials based on SCO complexes.

Published
2021
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29. Responsive Four-Coordinate Iron(II) Nodes in FePd(CN)4

Author

Koji Kimoto, Masatomo Yashima, Hiromu Matsunari, Takafumi Yamamoto, Hiroshi Kageyama, Akihide Kuwabara, Susumu Fujii, Masaaki Isobe, Shin Ichiro Noro, Yuh Hijikata, Ryo Ohtani, Masaaki Ohba, Shinya Hayami, and Kotaro Fujii

Subjects
Materials science, Neutron diffraction, Thermal treatment, 010402 general chemistry, 01 natural sciences, Catalysis, Ion, Metal, iron, Molecule, thermal expansion, chemistry.chemical_classification, cyanide, 010405 organic chemistry, General Chemistry, Polymer, General Medicine, 0104 chemical sciences, Crystallography, coordination polymers, chemistry, Transmission electron microscopy, visual_art, visual_art.visual_art_medium, Tetrahedron, four-coordination
Abstract

Metal node design is crucial for obtaining structurally diverse coordination polymers (CPs) and metal?organic frameworks with desirable properties; however, FeII ions are exclusively six-coordinated. Herein, we present a cyanide-bridged three-dimensional (3D) CP, FePd(CN)4, bearing four-coordinate FeII ions, which is synthesized by thermal treatment of a two-dimensional (2D) six-coordinate FeII CP, Fe(H2O)2Pd(CN)4?4?H2O, to remove water molecules. Atomic-resolution transmission electron microscopy and powder X-ray and neutron diffraction measurements revealed that the FePd(CN)4 structure is composed of a two-fold interpenetrated PtS topology network, where the FeII center demonstrates an intermediate geometry between tetrahedral and square-planar coordination. This four-coordinate FeII center with the distorted geometry can act as a thermo-responsive flexible node in the PtS network.

Published
2020

30. Swift and Efficient Nuclear Spin Conversion of Molecular Hydrogen Confined in Prussian Blue Analogs

Author

Masaaki Ohba, Akio Mishima, Akihiro Hori, Yuta Ohtsubo, Ryotaro Matsuda, and Ryo Ohtani

Subjects
Crystallography, Prussian blue, chemistry.chemical_compound, chemistry, 010405 organic chemistry, Hydrogen molecule, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Abstract

The ortho-isomer of molecular hydrogen (o-H2) was converted to the para-isomer (p-H2) within 600 s by using Prussian blue analogs, {MII3[CrIII(CN)6]2} (MCr; M = Mn and Ni), as nuclear-spin conversi...

Published
2020
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31. Association Between Serum Apolipoprotein A1 Levels, Ischemic Stroke Subtypes and Plaque Properties of the Carotid Artery

Author

Naoki Sakane, Ryo Ohtani, and Shinsuke Nirengi

Subjects
medicine.medical_specialty, Stroke patient, biology, Apolipoprotein B, Triglyceride, business.industry, Carotid arteries, Mixed type, Blood lipids, General Medicine, Gastroenterology, ApoA1, chemistry.chemical_compound, ATBI, chemistry, Internal medicine, Ischemic stroke, medicine, biology.protein, Original Article, lipids (amino acids, peptides, and proteins), Apolipoprotein A1, business, Plaque
Abstract

Background: This study aimed to investigate the association between serum apolipoprotein A1 (ApoA1) levels, ischemic stroke subtypes and plaque properties. Methods: We enrolled 92 patients with ischemic stroke and 21 age-matched controls (CONT). The stroke patients were divided into three subtypes: cardioembolic (CE, n = 15), atherothrombotic infraction (ATBI, n = 52), and lacunar infarction (LI, n = 25). Carotid plaques were classified as low, intermediate, or high intensity, and either simple or mixed type. Serum lipids (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG)), ApoA1, and ApoB were analyzed using commercially available kits. Results: There was no difference in TC, LDL-C, HDL-C, and ApoB levels among the four groups. Serum ApoA1 levels in the ATBI group were significantly lower compared with the CONT group. Among the ATBI group, the serum ApoA1 levels in the low-intensity plaque-type were significantly lower than those in the intermediate or hard-intensity plaque-type. Furthermore, serum ApoA1 levels in the mixed plaque-type were significantly lower than those in the simple type. Conclusions: These findings suggest that serum ApoA1 levels might be associated with the development of ATBI and plaque properties of the carotid artery. J Clin Med Res. 2020;12(9):598-603 doi: https://doi.org/10.14740/jocmr4284

Published
2020
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32. Vapor switching of the luminescence mechanism in a Re(<scp>v</scp>) complex

Author

Kenta Sasaki, Haruka Yoshino, Yuushi Shimoda, Kiyoshi Miyata, Ryo Ohtani, Hitomi Yamate, Masaaki Ohba, Ken Onda, and Hiroki Miura

Subjects
Materials science, Ligand, Metals and Alloys, Physics::Optics, Charge (physics), General Chemistry, Photochemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Color changes, Materials Chemistry, Ceramics and Composites, Methanol, Luminescence, Quantum, Astrophysics::Galaxy Astrophysics
Abstract

A ReV complex demonstrates methanol selective luminescent color changes from red to green together with enhancements of the corresponding luminescence quantum yields twenty-three times. These characteristic responses are caused by the switching of the characters of the emissive states from metal-to-ligand charge transfer to d-d transition along with a single-crystal-to-single-crystal ligand exchange reaction.

Published
2020
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33. Double-layered honeycomb architectures constructed via hierarchical self-assembly of hexagonal spin crossover cobalt(<scp>ii</scp>) metallacycles

Author

Keita Kuroiwa, Masaaki Nakamura, Mina Sakuragi, Ryohei Akiyoshi, Soichiro Yoshimoto, Shinya Hayami, Ryo Ohtani, and Leonard F. Lindoy

Subjects
Materials science, Hexagonal crystal system, Double layered, Metals and Alloys, Honeycomb (geometry), chemistry.chemical_element, General Chemistry, Metallacycle, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Crystallography, chemistry, Spin crossover, Materials Chemistry, Ceramics and Composites, Self-assembly, Cobalt
Abstract

A hexagonal cobalt(II) metallacycle and its “lipid packaged” derivatives, [Co6(R-bisterpy)6]X12 (R = H, OC16H33, OC27H55; X = BF4, C12-Glu), have been synthesized and characterized. The compounds incorporating BF4− anions formed sphere-like aggregates while the compounds with C12-Glu lipid anions gave double-layered honeycomb architectures composed of hexagonal stacked tubular structures, which exhibit spin crossover behaviour.

Published
2020
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34. Exploration of glassy state in Prussian blue analogues

Author

Nattapol Ma, Ryo Ohtani, Hung M. Le, Ryuta Ishikawa, Satoshi Kawata, Sareeya Bureekaew, Soracha Kosasang, Yoshiyuki Kawazoe, Koji Ohara, and Satoshi Horike

Abstract

Prussian blue analogues (PBAs), a class of microporous crystalline coordination frameworks, are long known for their diverse properties in porosity, magnetic, charge transport, catalysis, optics, and more. Versatile structural composition and the ability to control defect ordering through synthetic conditions offer opportunities to manipulate the functionality in the crystalline state. However, developments in Prussian blue analogues (PBAs) have primarily revolved around the ordered crystalline state, and the glassy state of PBAs has not yet been explored. Here we report the discovery of a disordered glassy state of the PBA via mechanically induced crystal–glass transformation. We found the preservation of metal–ligand–metal connectivity, confirming the short-range order and semiconductor behaviour, exhibiting an electronic conductivity value of 0.31 mS cm−1 at 50 ˚C. Mechanical-induced glass transformation also triggers changes in electronic states, where electroneutrality is compensated by introducing unconventional CN− vacancies. Partial disorders and ligand vacancies in recrystallized PBA give rise to an enhanced porosity, inaccessible in the crystalline parent. The present work also established a correlation between the mechanical stress required to initiate crystal–glass transformation and intrinsic mechanical properties, which are controlled by the vacancy/defect content, the presence of interstitial water, and the overall composition of PBAs.

Published
2021
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35. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author

Götz Thomalla, Florent Boutitie, Henry Ma, Masatoshi Koga, Peter Ringleb, Lee H Schwamm, Ona Wu, Martin Bendszus, Christopher F Bladin, Bruce C V Campbell, Bastian Cheng, Leonid Churilov, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Mayumi Fukuda-Doi, Manabu Inoue, Timothy J Kleinig, Lawrence L Latour, Robin Lemmens, Christopher R Levi, Didier Leys, Kaori Miwa, Carlos A Molina, Keith W Muir, Norbert Nighoghossian, Mark W Parsons, Salvador Pedraza, Peter D Schellinger, Stefan Schwab, Claus Z Simonsen, Shlee S Song, Vincent Thijs, Danilo Toni, Chung Y Hsu, Nils Wahlgren, Haruko Yamamoto, Nawaf Yassi, Sohei Yoshimura, Steven Warach, Werner Hacke, Kazunori Toyoda, Geoffrey A Donnan, Stephen M Davis, Christian Gerloff, Boris Raul Acosta, Karen Aegidius, Christian Albiker, Anna Alegiani, Miriam Almendrote, Angelika Alonso, Katharina Althaus, Pierre Amarenco, Hemasse Amiri, Bettina Anders, Adriana Aniculaesei, Jason Appleton, Juan Arenillas, Christina Back, Christian Bähr, Jürgen Bardutzky, Flore Baronnet-Chauvet, Rouven Bathe-Peters, Anna Bayer-Karpinska, Juan L. Becerra, Christoph Beck, Olga Belchí Guillamon, Amandine Benoit, Nadia Berhoune, Daniela Bindila, Julia Birchenall, Karine Blanc-Lasserre, Miguel Blanco Gonzales, Tobias Bobinger, Ulf Bodechtel, Eric Bodiguel, Urszula Bojaryn, Louise Bonnet, Benjamin Bouamra, Paul Bourgeois, Lorenz Breuer, Ludovic Breynaert, David Broughton, Raf Brouns, Sébastian Brugirard, Bart Bruneel, Florian Buggle, Serkan Cakmak, Ana Calleja, David Calvet, David Carrera, Hsin-Chieh Chen, Bharath Cheripelli, Tae-Hee Cho, Chi-un Choe, Lillian Choy, Hanne Christensen, Mareva Ciatipis, Geoffrey Cloud, Julien Cogez, Elisa Cortijo, Sophie Crozier, Dorte Damgaard, Krishna Dani, Beatrijs De Coene, Isabel De Hollander, Jacques De Keyser, Nina De Klippel, Charlotte De Maeseneire, Ann De Smedt, Maria del Mar Castellanos Rodrigo, Sandrine Deltour, Jelle Demeestere, Laurent Derex, Philippe Desfontaines, Ralf Dittrich, Anand Dixit, Laurens Dobbels, Valérie Domigo, Laura Dorado, Charlotte Druart, Kristina Hougaard Dupont, Anne Dusart, Rainer Dziewas, Matthias Ebner, Myriam Edjali-Goujon, Philipp Eisele, Salwa El Tawil, Ahmed Elhfnawy, Ana Etexberria, Nicholas Evans, Simon Fandler, Franz Fazekas, Sandra Felix, Jochen B. Fiebach, Jens Fiehler, Alexandra Filipov, Katharina Filipski, Robert Fleischmann, Christian Foerch, Ian Ford, Alexandra Gaenslen, Ivana Galinovic, Elena Meseguer Gancedo, Ramanan Ganeshan, Carlos García Esperón, Alicia Garrido, Thomas Gattringer, Olivia Geraghty, Rohat Geran, Stefan Gerner, Sylvie Godon-Hardy, Jos Göhler, Amir Golsari, Meritxell Gomis, David Gorriz, Verena Gramse, Laia Grau, Martin Griebe, Cristina Guerrero, Damla Guerzoglu, Sophie Guettier, Vincent Guiraud, Christoph Gumbinger, Ignaz Gunreben, Florian Haertig, Christian Hametner, Bernard Hanseeuw, Andreas Hansen, Jakob Hansen, Thomas Harbo, Andreas Harloff, Peter Harmel, Karl Georg Häusler, Florian Heinen, Valentin Held, Simon Hellwig, Dimitri Hemelsoet, Michael Hennerici, Juliane Herm, Sylvia Hermans, María Hernández, Jose Hervas Vicente, Niels Hjort, Cristina Hobeanu, Carsten Hobohm, Elmar Höfner, Katharina Hohenbichler, Marc Hommel, Julia Hoppe, Eva Hornberger, Carolin Hoyer, Xuya Huang, Nils Ipsen, Irina Isern, Lourdes Ispierto, Helle Iversen, Lise Jeppesen, Marta Jimenez, Jan Jungehülsing, Eric Jüttler, Dheeraj Kalladka, Bernd Kallmünzer, Arindam Kar, Lars Kellert, André Kemmling, Tobias Kessler, Usman Khan, Matthias Klein, Christoph Kleinschnitz, Matti Klockziem, Michael Knops, Luzie Koehler, Martin Koehrmann, Heinz Kohlfürst, Rainer Kollmar, Peter Kraft, Thomas Krause, Bo Kristensen, Jan M. Kröber, Natalia Kurka, Alexandre Ladoux, Patrice Laloux, Catherine Lamy, Emmanuelle Landrault, Arne Lauer, Claire Lebely, Jonathan Leempoel, Kennedy Lees, Anne Leger, Laurence Legrand, Lin Li, Anna-Mareike Löbbe, Frederic London, Elena Lopez-cancio, Matthias Lorenz, Stephen Louw, Caroline Lovelock, Manuel Lozano Sánchez, Giuseppe Lucente, Janos Lückl, Alain Luna, Kosmas Macha, Alexandre Machet, Daniel Mackenrodt, Dominik Madzar, Charles Majoie, Anika Männer, Vicky Maqueda, Jacob Marstrand, Alicia Martinez, Annika Marzina, Laura Mechthouff, Per Meden, Guy Meersman, Julia Meier, Charles Mellerio, Oliver Menn, Nadja Meyer, Dominik Michalski, Peter Michels, Lene Michelsen, Monica Millán Torne, Jens Minnerup, Boris Modrau, Sebastian Moeller, Anette Møller, Nathalie Morel, Fiona Moreton, Ludovic Morin, Thierry Moulin, Barry Moynihan, Anne K. Mueller, Keith W. Muir, Patricia Mulero, Sibu Mundiyanapurath, Johannes Mutzenbach, Simon Nagel, Oliver Naggara, Arumugam Nallasivan, Irene Navalpotro, Alexander H. Nave, Paul Nederkoorn, Lars Neeb, Hermann Neugebauer, Tobias Neumann-Haefelin, Stefan Oberndorfer, Christian Opherk, Lorenz Oppel, Catherine Oppenheim, Johannes Orthgieß, Leif Ostergaard, Perrine Paindeville, Ernest Palomeras, Verena Panitz, Bhavni Patel, Andre Peeters, Dirk Peeters, Anna Pellisé, Johann Pelz, Anthony Pereira, Natalia Pérez de la Ossa, Richard Perry, Salvador Petraza, Stéphane Peysson, Waltraud Pfeilschifter, Alexander Pichler, Alexandra Pierskalla, Hans-Werner Pledl, Sven Poli, Katrin Pomrehn, Marika Poulsen, Luis Prats, Silvia Presas, Elisabeth Prohaska, Volker Puetz, Josep Puig, Josep Puig Alcántara, Jan Purrucker, Veronique Quenardelle, Sankaranarayanan Ramachandran, Soulliard Raphaelle, Nicolas Raposo, Tilman Reiff, Michel Remmers, Pauline Renou, Martin Ribitsch, Hardy Richter, Martin Ritter, Thomas Ritzenthaler, Gilles Rodier, Christine Rodriguez-Regent, Manuel Rodríguez-Yáñez, Maria Roennefarth, Christine Roffe, Sverre Rosenbaum, Charlotte Rosso, Joachim Röther, Michal Rozanski, Noelia Ruiz de Morales, Francesca Russo, Matthieu Rutgers, Sharmilla Sagnier, Yves Samson, Josep Sánchez, Tamara Sauer, Jan H. Schäfer, Simon Schieber, Josef Schill, Dennis Schlak, Ludwig Schlemm, Sein Schmidt, Wouter Schonewille, Julian Schröder, Andreas Schulz, Johannes Schurig, Sönke Schwarting, Alexander Schwarz, Christopher Schwarzbach, Matthias Seidel, Alexander Seiler, Jochen Sembill, Joaquin Serena Leal, Ashit Shetty, Igor Sibon, Claus Z. Simonsen, Oliver Singer, Aravinth Sivagnanaratham, Ide Smets, Craig Smith, Peter Soors, Nikola Sprigg, Maximilian Spruegel, David Stark, Susanne Steinert, Sebastian Stösser, Markus Stuermlinger, Bart Swinnen, Ruben Tamazyan, Jose Tembl, Mikel Terceno Izaga, Emmanuel Touze, Thomas Truelsen, Guillaume Turc, Gaetane Turine, Serdar Tütüncü, Pippa Tyrell, Xavier Ustrell, Wilfried Vadot, Anne-Evelyne Vallet, Pauline Vallet, Lucie van den Berg, Sophie van den Berg, Cecile van Eendenburg, Robbert-Jan Van Hooff, Isabelle van Sloten, Peter Vanacker, Evelien Vancaester, Patrick Vanderdonckt, Yves Vandermeeren, Frederik Vanhee, Roland Veltkamp, Karsten Vestergaard, Alain Viguier, Dolores Vilas, Kersten Villringer, Dieke Voget, Jörg von Schrader, Paul von Weitzel, Elisabeth Warburton, Claudia Weber, Jörg Weber, Karl Wegscheider, Mirko Wegscheider, Christian Weimar, Karin Weinstich, Christopher Weise, Gesa Weise, Chris Willems, Klemens Winder, Matthias Wittayer, Marc Wolf, Martin Wolf, Valerie Wolff, Christian Wollboldt, Frank Wollenweber, Anke Wouters, Bertrand Yalo, Marion Yger, Nadia Younan, Laetita Yperzeele, Vesna Zegarac, Pia Zeiner, Ulf Ziemann, Thomas Zonneveld, Mathieu Zuber, Tsugio Akutsu, Junya Aoki, Shuji Arakawa, Ryosuke Doijiri, Yusuke Egashira, Yukiko Enomoto, Eisuke Furui, Konosuke Furuta, Seiji Gotoh, Toshimitsu Hamasaki, Yasuhiro Hasegawa, Teryuki Hirano, Kazunari Homma, Masahiko Ichijyo, Toshihiro Ide, Shuichi Igarashi, Yasuyuki Iguchi, Masafumi Ihara, Hajime Ikenouchi, Tsuyoshi Inoue, Ryo Itabashi, Yasuhiro Ito, Toru Iwama, Kenji Kamiyama, Shoko Kamiyoshi, Haruka Kanai, Yasuhisa Kanematsu, Takao Kanzawa, Kazumi Kimura, Jiro Kitayama, Takanari Kitazono, Rei Kondo, Kohsuke Kudo, Masayoshi Kusumi, Ken Kuwahara, Shoji Matsumoto, Hideki Matsuoka, Ban Mihara, Kazuo Minematsu, Ken Miura, Naomi Morita, Wataru Mouri, Kayo Murata, Yoshinari Nagakane, Taizen Nakase, Hiromi Ohara, Nobuyuki Ohara, Hideyuki Ohnishi, Hajime Ohta, Masafumi Ohtaki, Ryo Ohtani, Toshiho Ohtsuki, Hideo Ohyama, Takashi Okada, Yasushi Okada, Masato Osaki, Nobuyuki Sakai, Yoshiki Sanbongi, Naoshi Sasaki, Makoto Sasaki, Shoichiro Sato, Kenta Seki, Wataru Shimizu, Yoshiaki Shiokawa, Takashi Sozu, Junichiro Suzuki, Rieko Suzuki, Yasushi Takagi, Shunya Takizawa, Norio Tanahashi, Eijiro Tanaka, Ryota Tanaka, Yohei Tateishi, Tomoaki Terada, Tadashi Terasaki, Kenichi Todo, Azusa Tokunaga, Akira Tsujino, Toshihiro Ueda, Yoshikazu Uesaka, Mihoko Uotani, Takao Urabe, Masao Watanabe, Yoshiki Yagita, Yusuke Yakushiji, Keizo Yasui, Toshiro Yonehara, Shinichi Yoshimura, K. Aarnio, F. Alemseged, C. Anderson, T. Ang, M.L. Archer, J. Attia, P. Bailey, A. Balabanski, A. Barber, P.A. Barber, J. Bernhardt, A. Bivard, D. Blacker, C.F. Bladin, A. Brodtmann, D. Cadilhac, B.C.V. Campbell, L. Carey, S. Celestino, L. Chan, W.H. Chang, A. ChangI, C.H. Chen, C.-I. Chen, H.F. Chen, T.C. Chen, W.H. Chen, Y.Y. Chen, C.A. Cheng, E. Cheong, Y.W. Chiou, P.M. Choi, H.J. Chu, C.S. Chuang, T.C. Chung, L. Churilov, B. Clissold, A. Connelly, S. Coote, B. Coulton, E. Cowley, J. Cranefield, S. Curtze, C. D'Este, S.M. Davis, S. Day, P.M. Desmond, H.M. Dewey, C. Ding, G.A. Donnan, R. Drew, S. Eirola, D. Field, T. Frost, C. Garcia-Esperon, K. George, R. Gerraty, R. Grimley, Y.C. Guo, G. Hankey, J. Harvey, S.C. Ho, K. Hogan, D. Howells, P.M. Hsiao, C.H. Hsu, C.T. Hsu, C.-S. Hsu, J.P. Hsu, Y.D. Hsu, Y.T. Hsu, C.J. Hu, C.C. Huang, H.Y. Huang, M.Y. Huang, S.C. Huang, W.S. Huang, D. Jackson, J.S. Jeng, S.K. Jiang, L. Kaauwai, O. Kasari, J. King, T.J. Kleinig, M. Koivu, J. Kolbe, M. Krause, C.W. Kuan, W.L. Kung, C. Kyndt, C.L. Lau, A. Lee, C.Y. Lee, J.T. Lee, Y. Lee, Y.C. Lee, C. Levi, C.R. Levi, L.M. Lien, J.C. Lim, C.C. Lin, C.H. Lin, C.M. Lin, D. Lin, C.H. Liu, J. Liu, Y.C. Lo, P.S. Loh, E. Low, C.H. Lu, C.J. Lu, M.K. Lu, J. Ly, H. Ma, L. Macaulay, R. Macdonnell, E. Mackey, M. Macleod, J. Mahadevan, V. Maxwell, R. McCoy, A. McDonald, S. McModie, A. Meretoja, S. Mishra, P.J. Mitchell, F. Miteff, A. Moore, C. Muller, F. Ng, F.C. Ng, J-L. Ng, W. O'Brian, V. O'Collins, T.J. Oxley, M.W. Parsons, S. Patel, G.S. Peng, L. Pesavento, T. Phan, E. Rodrigues, Z. Ross, A. Sabet, M. Sallaberger, P. Salvaris, D. Shah, G. Sharma, G. Sibolt, M. Simpson, S. Singhal, B. Snow, N. Spratt, R. Stark, J. Sturm, M.C. Sun, Y. Sun, P.S. Sung, Y.F. Sung, M. Suzuki, M. Tan, S.C. Tang, T. Tatlisumak, V. Thijs, M. Tiainen, C.H. Tsai, C.K. Tsai, C.L. Tsai, H.T. Tsai, L.K. Tsai, C.H. Tseng, L.T. Tseng, J. Tsoleridis, H. Tu, H.T-H. Tu, W. Vallat, J. Virta, W.C. Wang, Y.T. Wang, M. Waters, L. Weir, T. Wijeratne, C. Williams, W. Wilson, A.A. Wong, K. Wong, T.Y. Wu, Y.H. Wu, B. Yan, F.C. Yang, Y.W. Yang, N. Yassi, H.L. Yeh, J.H. Yeh, S.J. Yeh, C.H. Yen, D. Young, C.L. Ysai, W.W. Zhang, H. Zhao, L. Zhao, Katharina Althaus-Knaurer, Jörg Berrouschot, Erich Bluhmki, Paolo Bovi, Gilles Chatellier, Lynda Cove, Stephen Davis, A. Dixit, Geoffrey Donnan, Christina Ehrenkrona, Christoph Eschenfelder, Marc Fatar, Juan Francisco Arenillas, Franz Gruber, Lalit Kala, Peter Kapeller, Markku Kaste, Christof Kessler, Martin Köhrmann, Rico Laage, Kennedy R. Lees, Alain Luna Rodriguez, Jean-Louis Mas, Robert Mikulik, Carlos Molina, Girish Muddegowda, Keith Muir, Kurt Niederkorn, Xavier Nuñez, Peter Schellinger, Joaquin Serena, Jan Sobesky, Thorsten Steiner, Ann-Sofie Svenson, Rüdiger von Kummer, Joanna Wardlaw, Rebecca A. Betensky, Gregoire Boulouis, Raphael A. Carandang, William A. Copen, Pedro Cougo, Shawna Cutting, Kendra Drake, Andria L. Ford, John Hallenbeck, Gordon J. Harris, Robert Hoesch, Amie Hsia, Carlos Kase, Lawrence Latour, Michael H. Lev, Alona Muzikansky, Nandakumar Nagaraja, Lee H. Schwamm, Eric Searls, Shlee S. Song, Sidney Starkman, Albert J. Yoo, Ramin Zand, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Monash University [Melbourne], National Cerebral and Cardiovascular Center (NCCC - OSAKA), Osaka University [Osaka], University of Heidelberg, Medical Faculty, Massachusetts General Hospital [Boston], University of Melbourne, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Royal Adelaide Hospital [Adelaide Australia], National Institute of Neurological Disorders and Stroke [Bethesda] (NINDS), National Institutes of Health [Bethesda] (NIH), University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Flanders Make [Leuven], Flanders Make, University of Newcastle [Australia] (UoN), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Vall d'Hebron University Hospital [Barcelona], University of Glasgow, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Girona Biomedical Research Institute [Girona, Spain] (IDIBGI), Ruhr-Universität Bochum [Bochum], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Aarhus University Hospital, Cedars-Sinai Medical Center, Florey Institute of Neuroscience and Mental Health [Melbourne, Victoria, Australia], Austin Health, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], China Medical University Hospital [Taichung], Karolinska Institutet [Stockholm], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Texas at Austin [Austin], Collaborators Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators: Boris Raul Acosta, Karen Aegidius, Christian Albiker, Anna Alegiani, Miriam Almendrote, Angelika Alonso, Katharina Althaus, Pierre Amarenco, Hemasse Amiri, Bettina Anders, Adriana Aniculaesei, Jason Appleton, Juan Arenillas, Christina Back, Christian Bähr, Jürgen Bardutzky, Flore Baronnet-Chauvet, Rouven Bathe-Peters, Anna Bayer-Karpinska, Juan L Becerra, Christoph Beck, Olga Belchí Guillamon, Amandine Benoit, Nadia Berhoune, Daniela Bindila, Julia Birchenall, Karine Blanc-Lasserre, Miguel Blanco Gonzales, Tobias Bobinger, Ulf Bodechtel, Eric Bodiguel, Urszula Bojaryn, Louise Bonnet, Benjamin Bouamra, Paul Bourgeois, Florent Boutitie, Lorenz Breuer, Ludovic Breynaert, David Broughton, Raf Brouns, Sébastian Brugirard, Bart Bruneel, Florian Buggle, Serkan Cakmak, Ana Calleja, David Calvet, David Carrera, Hsin-Chieh Chen, Bastian Cheng, Bharath Cheripelli, Tae-Hee Cho, Chi-Un Choe, Lillian Choy, Hanne Christensen, Mareva Ciatipis, Geoffrey Cloud, Julien Cogez, Elisa Cortijo, Sophie Crozier, Dorte Damgaard, Krishna Dani, Beatrijs De Coene, Isabel De Hollander, Jacques De Keyser, Nina De Klippel, Charlotte De Maeseneire, Ann De Smedt, Maria Del Mar Castellanos Rodrigo, Sandrine Deltour, Jelle Demeestere, Laurent Derex, Philippe Desfontaines, Ralf Dittrich, Anand Dixit, Laurens Dobbels, Valérie Domigo, Laura Dorado, Charlotte Druart, Kristina Hougaard Dupont, Anne Dusart, Rainer Dziewas, Martin Ebinger, Matthias Ebner, Myriam Edjali-Goujon, Philipp Eisele, Salwa El Tawil, Ahmed Elhfnawy, Matthias Endres, Ana Etexberria, Nicholas Evans, Simon Fandler, Franz Fazekas, Sandra Felix, Jochen B Fiebach, Jens Fiehler, Alexandra Filipov, Katharina Filipski, Robert Fleischmann, Christian Foerch, Ian Ford, Alexandra Gaenslen, Ivana Galinovic, Elena Meseguer Gancedo, Ramanan Ganeshan, Carlos García Esperón, Alicia Garrido, Thomas Gattringer, Olivia Geraghty, Rohat Geran, Christian Gerloff, Stefan Gerner, Sylvie Godon-Hardy, Jos Göhler, Amir Golsari, Meritxell Gomis, David Gorriz, Verena Gramse, Laia Grau, Martin Griebe, Cristina Guerrero, Damla Guerzoglu, Sophie Guettier, Vincent Guiraud, Christoph Gumbinger, Ignaz Gunreben, Florian Haertig, Christian Hametner, Bernard Hanseeuw, Andreas Hansen, Jakob Hansen, Thomas Harbo, Andreas Harloff, Peter Harmel, Karl Georg Häusler, Florian Heinen, Valentin Held, Simon Hellwig, Dimitri Hemelsoet, Michael Hennerici, Juliane Herm, Sylvia Hermans, María Hernández, Jose Hervas Vicente, Niels Hjort, Cristina Hobeanu, Carsten Hobohm, Elmar Höfner, Katharina Hohenbichler, Marc Hommel, Julia Hoppe, Eva Hornberger, Carolin Hoyer, Xuya Huang, Nils Ipsen, Irina Isern, Lourdes Ispierto, Helle Iversen, Lise Jeppesen, Marta Jimenez, Jan Jungehülsing, Eric Jüttler, Dheeraj Kalladka, Bernd Kallmünzer, Arindam Kar, Lars Kellert, André Kemmling, Tobias Kessler, Usman Khan, Matthias Klein, Christoph Kleinschnitz, Matti Klockziem, Michael Knops, Luzie Koehler, Martin Koehrmann, Heinz Kohlfürst, Rainer Kollmar, Peter Kraft, Thomas Krause, Bo Kristensen, Jan M Kröber, Natalia Kurka, Alexandre Ladoux, Patrice Laloux, Catherine Lamy, Emmanuelle Landrault, Arne Lauer, Claire Lebely, Jonathan Leempoel, Kennedy Lees, Anne Leger, Laurence Legrand, Robin Lemmens, Lin Li, Anna-Mareike Löbbe, Frederic London, Elena Lopez-Cancio, Matthias Lorenz, Stephen Louw, Caroline Lovelock, Manuel Lozano Sánchez, Giuseppe Lucente, Janos Lückl, Alain Luna, Kosmas Macha, Alexandre Machet, Daniel Mackenrodt, Dominik Madzar, Charles Majoie, Anika Männer, Vicky Maqueda, Jacob Marstrand, Alicia Martinez, Annika Marzina, Laura Mechthouff, Per Meden, Guy Meersman, Julia Meier, Charles Mellerio, Oliver Menn, Nadja Meyer, Dominik Michalski, Peter Michels, Lene Michelsen, Monica Millán Torne, Jens Minnerup, Boris Modrau, Sebastian Moeller, Anette Møller, Nathalie Morel, Fiona Moreton, Ludovic Morin, Thierry Moulin, Barry Moynihan, Anne K Mueller, Keith W Muir, Patricia Mulero, Sibu Mundiyanapurath, Johannes Mutzenbach, Simon Nagel, Oliver Naggara, Arumugam Nallasivan, Irene Navalpotro, Alexander H Nave, Paul Nederkoorn, Lars Neeb, Hermann Neugebauer, Tobias Neumann-Haefelin, Norbert Nighoghossian, Stefan Oberndorfer, Christian Opherk, Lorenz Oppel, Catherine Oppenheim, Johannes Orthgieß, Leif Ostergaard, Perrine Paindeville, Ernest Palomeras, Verena Panitz, Bhavni Patel, Andre Peeters, Dirk Peeters, Anna Pellisé, Johann Pelz, Anthony Pereira, Natalia Pérez de la Ossa, Richard Perry, Salvador Petraza, Stéphane Peysson, Waltraud Pfeilschifter, Alexander Pichler, Alexandra Pierskalla, Hans-Werner Pledl, Sven Poli, Katrin Pomrehn, Marika Poulsen, Luis Prats, Silvia Presas, Elisabeth Prohaska, Volker Puetz, Josep Puig, Josep Puig Alcántara, Jan Purrucker, Veronique Quenardelle, Sankaranarayanan Ramachandran, Soulliard Raphaelle, Nicolas Raposo, Tilman Reiff, Michel Remmers, Pauline Renou, Martin Ribitsch, Hardy Richter, Peter Ringleb, Martin Ritter, Thomas Ritzenthaler, Gilles Rodier, Christine Rodriguez-Regent, Manuel Rodríguez-Yáñez, Maria Roennefarth, Christine Roffe, Sverre Rosenbaum, Charlotte Rosso, Joachim Röther, Michal Rozanski, Noelia Ruiz de Morales, Francesca Russo, Matthieu Rutgers, Sharmilla Sagnier, Yves Samson, Josep Sánchez, Tamara Sauer, Jan H Schäfer, Simon Schieber, Josef Schill, Dennis Schlak, Ludwig Schlemm, Sein Schmidt, Wouter Schonewille, Julian Schröder, Andreas Schulz, Johannes Schurig, Sönke Schwarting, Alexander Schwarz, Christopher Schwarzbach, Matthias Seidel, Alexander Seiler, Jochen Sembill, Joaquin Serena Leal, Ashit Shetty, Igor Sibon, Claus Z Simonsen, Oliver Singer, Aravinth Sivagnanaratham, Ide Smets, Craig Smith, Peter Soors, Nikola Sprigg, Maximilian Spruegel, David Stark, Susanne Steinert, Sebastian Stösser, Markus Stuermlinger, Bart Swinnen, Ruben Tamazyan, Jose Tembl, Mikel Terceno Izaga, Vincent Thijs, Götz Thomalla, Emmanuel Touze, Thomas Truelsen, Guillaume Turc, Gaetane Turine, Serdar Tütüncü, Pippa Tyrell, Xavier Ustrell, Wilfried Vadot, Anne-Evelyne Vallet, Pauline Vallet, Lucie van den Berg, Sophie van den Berg, Cecile van Eendenburg, Robbert-Jan Van Hooff, Isabelle van Sloten, Peter Vanacker, Evelien Vancaester, Patrick Vanderdonckt, Yves Vandermeeren, Frederik Vanhee, Roland Veltkamp, Karsten Vestergaard, Alain Viguier, Dolores Vilas, Kersten Villringer, Dieke Voget, Jörg von Schrader, Paul von Weitzel, Elisabeth Warburton, Claudia Weber, Jörg Weber, Karl Wegscheider, Mirko Wegscheider, Christian Weimar, Karin Weinstich, Christopher Weise, Gesa Weise, Chris Willems, Klemens Winder, Matthias Wittayer, Marc Wolf, Martin Wolf, Valerie Wolff, Christian Wollboldt, Frank Wollenweber, Anke Wouters, Bertrand Yalo, Marion Yger, Nadia Younan, Laetita Yperzeele, Vesna Zegarac, Pia Zeiner, Ulf Ziemann, Thomas Zonneveld, Mathieu Zuber, Tsugio Akutsu, Junya Aoki, Junya Aoki, Shuji Arakawa, Ryosuke Doijiri, Yusuke Egashira, Yukiko Enomoto, Mayumi Fukuda-Doi, Eisuke Furui, Konosuke Furuta, Seiji Gotoh, Toshimitsu Hamasaki, Yasuhiro Hasegawa, Teryuki Hirano, Kazunari Homma, Masahiko Ichijyo, Toshihiro Ide, Shuichi Igarashi, Yasuyuki Iguchi, Masafumi Ihara, Hajime Ikenouchi, Manabu Inoue, Tsuyoshi Inoue, Ryo Itabashi, Yasuhiro Ito, Toru Iwama, Kenji Kamiyama, Shoko Kamiyoshi, Haruka Kanai, Yasuhisa Kanematsu, Takao Kanzawa, Kazumi Kimura, Jiro Kitayama, Takanari Kitazono, Masatoshi Koga, Rei Kondo, Kohsuke Kudo, Masayoshi Kusumi, Ken Kuwahara, Shoji Matsumoto, Hideki Matsuoka, Ban Mihara, Kazuo Minematsu, Ken Miura, Kaori Miwa, Naomi Morita, Wataru Mouri, Kayo Murata, Yoshinari Nagakane, Taizen Nakase, Hiromi Ohara, Nobuyuki Ohara, Hideyuki Ohnishi, Hajime Ohta, Masafumi Ohtaki, Ryo Ohtani, Toshiho Ohtsuki, Hideo Ohyama, Takashi Okada, Yasushi Okada, Masato Osaki, Nobuyuki Sakai, Yoshiki Sanbongi, Naoshi Sasaki, Makoto Sasaki, Shoichiro Sato, Kenta Seki, Wataru Shimizu, Yoshiaki Shiokawa, Takashi Sozu, Junichiro Suzuki, Rieko Suzuki, Yasushi Takagi, Shunya Takizawa, Norio Tanahashi, Eijiro Tanaka, Ryota Tanaka, Yohei Tateishi, Tomoaki Terada, Tadashi Terasaki, Kenichi Todo, Azusa Tokunaga, Kazunori Toyoda, Akira Tsujino, Toshihiro Ueda, Yoshikazu Uesaka, Mihoko Uotani, Takao Urabe, Masao Watanabe, Yoshiki Yagita, Yusuke Yakushiji, Haruko Yamamoto, Keizo Yasui, Toshiro Yonehara, Sohei Yoshimura, Shinichi Yoshimura, K Aarnio, F Alemseged, C Anderson, T Ang, M L Archer, J Attia, P Bailey, A Balabanski, A Barber, P A Barber, J Bernhardt, A Bivard, D Blacker, C F Bladin, A Brodtmann, D Cadilhac, B C V Campbell, L Carey, S Celestino, L Chan, W H Chang, A ChangI, C H Chen, C-I Chen, H F Chen, T C Chen, W H Chen, Y Y Chen, C A Cheng, E Cheong, Y W Chiou, P M Choi, H J Chu, C S Chuang, T C Chung, L Churilov, B Clissold, A Connelly, S Coote, B Coulton, E Cowley, J Cranefield, S Curtze, C D'Este, S M Davis, S Day, P M Desmond, H M Dewey, C Ding, G A Donnan, R Drew, S Eirola, D Field, T Frost, C Garcia-Esperon, K George, R Gerraty, R Grimley, Y C Guo, G Hankey, J Harvey, S C Ho, K Hogan, D Howells, P M Hsiao, C H Hsu, C T Hsu, C-S Hsu, J P Hsu, Y D Hsu, Y T Hsu, C J Hu, C C Huang, H Y Huang, M Y Huang, S C Huang, W S Huang, D Jackson, J S Jeng, S K Jiang, L Kaauwai, O Kasari, J King, T J Kleinig, M Koivu, J Kolbe, M Krause, C W Kuan, W L Kung, C Kyndt, C L Lau, A Lee, C Y Lee, J T Lee, Y Lee, Y C Lee, C Levi, C R Levi, L M Lien, J C Lim, C C Lin, C H Lin, C M Lin, D Lin, C H Liu, J Liu, Y C Lo, P S Loh, E Low, C H Lu, C J Lu, M K Lu, J Ly, H Ma, L Macaulay, R Macdonnell, E Mackey, M Macleod, J Mahadevan, V Maxwell, R McCoy, A McDonald, S McModie, A Meretoja, S Mishra, P J Mitchell, F Miteff, A Moore, C Muller, F Ng, F C Ng, J-L Ng, W O'Brian, V O'Collins, T J Oxley, M W Parsons, S Patel, G S Peng, L Pesavento, T Phan, E Rodrigues, Z Ross, A Sabet, M Sallaberger, P Salvaris, D Shah, G Sharma, G Sibolt, M Simpson, S Singhal, B Snow, N Spratt, R Stark, J Sturm, M C Sun, Y Sun, P S Sung, Y F Sung, M Suzuki, M Tan, S C Tang, T Tatlisumak, V Thijs, M Tiainen, C H Tsai, C K Tsai, C L Tsai, H T Tsai, L K Tsai, C H Tseng, L T Tseng, J Tsoleridis, H Tu, H T-H Tu, W Vallat, J Virta, W C Wang, Y T Wang, M Waters, L Weir, T Wijeratne, C Williams, W Wilson, A A Wong, K Wong, T Y Wu, Y H Wu, B Yan, F C Yang, Y W Yang, N Yassi, H L Yeh, J H Yeh, S J Yeh, C H Yen, D Young, C L Ysai, W W Zhang, H Zhao, L Zhao, Katharina Althaus-Knaurer, Martin Bendszus, Jörg Berrouschot, Erich Bluhmki, Paolo Bovi, Gilles Chatellier, Lynda Cove, Stephen Davis, A Dixit, Geoffrey Donnan, Rainer Dziewas, Christina Ehrenkrona, Christoph Eschenfelder, Marc Fatar, Juan Francisco Arenillas, Franz Gruber, Werner Hacke, Lalit Kala, Peter Kapeller, Markku Kaste, Christof Kessler, Martin Köhrmann, Rico Laage, Kennedy R Lees, Didier Leys, Alain Luna Rodriguez, Jean-Louis Mas, Robert Mikulik, Carlos Molina, Girish Muddegowda, Keith Muir, Kurt Niederkorn, Xavier Nuñez, Catherine Oppenheim, Sven Poli, Peter Ringleb, Peter Schellinger, Stefan Schwab, Joaquin Serena, Jan Sobesky, Thorsten Steiner, Ann-Sofie Svenson, Danilo Toni, Roland Veltkamp, Rüdiger von Kummer, Nils Wahlgren, Joanna Wardlaw, Rebecca A Betensky, Gregoire Boulouis, Raphael A Carandang, William A Copen, Pedro Cougo, Shawna Cutting, Kendra Drake, Andria L Ford, John Hallenbeck, Gordon J Harris, Robert Hoesch, Amie Hsia, Carlos Kase, Lawrence Latour, Arne Lauer, Michael H Lev, Alona Muzikansky, Nandakumar Nagaraja, Lee H Schwamm, Eric Searls, Shlee S Song, Sidney Starkman, Steven Warach, Ona Wu, Albert J Yoo, Ramin Zand, University of Newcastle [Callaghan, Australia] (UoN), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CarMeN, laboratoire, Yperzeele, Laetitia, Evaluation of Unknown Onset Stroke Thrombolysis trials (EOS) investigators, UCL - SSS/IONS - Institute of NeuroScience, UCL - (MGD) Service de neurologie, Supporting clinical sciences, UZB Other, Physical Medicine and Rehabilitation, Clinical sciences, Neuroprotection & Neuromodulation, Radiology and Nuclear Medicine, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Center of Experimental and Molecular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation

Subjects
medicine.medical_treatment, [SDV]Life Sciences [q-bio], Ischemic Stroke/*diagnostic imaging/*drug therapy, Tomography, X-Ray Computed/methods, Fibrinolytic Agents/adverse effects/*therapeutic use, 030204 cardiovascular system & hematology, Ischemic Stroke/diagnostic imaging, surgery, 0302 clinical medicine, Modified Rankin Scale, 030212 general & internal medicine, 10. No inequality, Infusions, Intravenous, Stroke, Tomography, Time-to-Treatment, General Medicine, Thrombolysis, X-Ray Computed/methods, Tissue Plasminogen Activator/adverse effects, 3. Good health, [SDV] Life Sciences [q-bio], Diffusion Magnetic Resonance Imaging/methods, Treatment Outcome, Meta-analysis, Tissue Plasminogen Activator, Intravenous, medicine.medical_specialty, Infusions, Intravenous thrombolysis, Neuroimaging, Neuroscience(all), Placebo, Tissue Plasminogen Activator/adverse effects/*therapeutic use, 03 medical and health sciences, Fibrinolytic Agents, Internal medicine, medicine, Humans, ddc:610, Ischemic Stroke, business.industry, neurology, Fibrinolytic Agents/adverse effects, Odds ratio, Recovery of Function, medicine.disease, Clinical research, Diffusion Magnetic Resonance Imaging, Human medicine, business, Tomography, X-Ray Computed, Fibrinolytic agent
Abstract

International audience; BACKGROUND: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. METHODS: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0-1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0-2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4-6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. FINDINGS: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10-2·03]; p=0·011), with low heterogeneity across studies (I(2)=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05-1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06-2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4-6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52-1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03-4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [\textless1%], adjusted OR 5·58 [1·22-25·50]; p=0·024). INTERPRETATION: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. FUNDING: None.

Published
2020
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36. Homo- and Heterosolvent Modifications of Hofmann-Type Flexible Two-Dimensional Layers for Colossal Interlayer Thermal Expansions

Author

Masaaki Ohba, Ryo Ohtani, Junichi Yanagisawa, Leonard F. Lindoy, Hiromu Matsunari, and Shinya Hayami

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Polymer, Type (model theory), 010402 general chemistry, 01 natural sciences, Thermal expansion, 0104 chemical sciences, Inorganic Chemistry, Crystallography, Thermal, Physical and Theoretical Chemistry, Anisotropy, Layer (electronics)
Abstract

Two-dimensional Hofmann-type coordination polymers of type Mn(H2O)2[Pd(CN)4]·xH2O (1·xH2O; x = 0, 1, and 4), Mn(H2O)(MeOH)[Pd(CN)4]·2MeOH (2·2MeOH), and Mn(MeOH)2[Pd(CN)4]·MeOH (3·MeOH) have been synthesized. The homosolvent-bound 1·4H2O, 1·H2O, and 3·MeOH polymers consist of undulating layer structures, whereas the structure of heterosolvent-bound 2·2MeOH consists of "Janus-like" flat layers in which water-bound and MeOH-bound-sides are present. 1·4H2O and 1·H2O exhibited anisotropic two-dimensional thermal expansions involving structural transformations of the undulating layers; one layer axis expands while the other contracts. 2·2MeOH exhibits anisotropic thermal expansion in which the flat layers shift sideways as the temperature is increased, with colossal interlayer expansion occurring (αc = +200 MK-1 over 140-180 K, αc = +165 MK-1 over 200-280 K). 3·MeOH also showed colossal interlayer expansion (αc = +216 MK-1) together with expansion of the undulating layers.

Published
2019
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37. Pretreatment Blood Pressure is a Simple Predictor of Hemorrhagic Infarction after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) Therapy

Author

Ryota Matsunari, Masaki Takata, Makoto Sainouchi, Naoki Sakane, Kento Doi, Tetsuya Tsukahara, Yuichi Masuda, Jumpei Togawa, Yasuhiro Kuwata, Osamu Kawakami, Michikazu Nakamura, Kiyoaki Takeda, Shinsuke Nirengi, and Ryo Ohtani

Subjects
Male, medicine.medical_specialty, Blood Pressure, Risk Assessment, Tissue plasminogen activator, Asymptomatic, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Risk Factors, Internal medicine, medicine, Humans, Thrombolytic Therapy, Registries, Infusions, Intravenous, Stroke, Aged, Retrospective Studies, Aged, 80 and over, Receiver operating characteristic, business.industry, Cerebral infarction, Rehabilitation, Area under the curve, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Recombinant Proteins, Confidence interval, Treatment Outcome, Blood pressure, Tissue Plasminogen Activator, Female, Surgery, Neurology (clinical), medicine.symptom, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background Hemorrhagic infarction (HI) is among the most severe complications that can occur following the administration of intravenous recombinant tissue plasminogen activator (rt-PA). In the present study, we aimed to determine the optimal cut-off points of blood pressure (BP) for HI after rt-PA treatment, and to compare our findings with those for other prediction models. Methods We analyzed data from 109 consecutive patients with stroke treated at our hospital between 2009 and 2016. HI was confirmed via computed tomography or magnetic resonance imaging. Patients were classified into a symptomatic HI group, an asymptomatic HI group, and a non-HI group. BP was measured on admission and before rt-PA treatment. Glucose Race Age Sex Pressure Stroke Severity (GRASPS) and Totaled Health Risks in Vascular Events (THRIVE) scores were also calculated. Receiver operating characteristic (ROC) analysis was used to determine factors associated with symptomatic and asymptomatic HI. Results Among the 109 total patients, 25 patients developed symptomatic HI, while 22 patients developed asymptomatic HI. ROC analysis for predicting symptomatic and asymptomatic HI revealed that the area under the curve for pretreatment systolic BP (SBP) was .88 (95% confidence interval[CI]: .83-.94), while those for GRASPS and THRIVE scores were .75 (95% CI: .66-.85) and .69 (95% CI: .59-.79), respectively. We identified an optimal cut-off point of 160 mm Hg (sensitivity: 82.3%; specificity: 76.6%; diagnostic accuracy: 80.0%; positive predictive value: 76.6%; negative predictive value: 82.5%). Conclusions Pre-treatment SBP may be a simple predictor of symptomatic and asymptomatic HI in patients with stroke undergoing rt-PA treatment.

Published
2019
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38. An autopsy case after endovascular thrombectomy for cardioembolic stroke due to nonbacterial thrombotic endocarditis

Author

Ryo Ohtani, Ken Yasuda, Nagako Murase, Michikazu Nakamura, Yasuhiro Kawabata, and Takashi Ayaki

Subjects
Blood Platelets, medicine.medical_specialty, Multiple Organ Failure, Myocardial Infarction, Neuroimaging, Autopsy, Nonbacterial thrombotic endocarditis, Metastasis, 03 medical and health sciences, Fatal Outcome, 0302 clinical medicine, Internal medicine, Mitral valve, Humans, Medicine, cardiovascular diseases, Thrombus, Contraindication, Aged, Thrombectomy, business.industry, Cerebral infarction, Endovascular Procedures, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Endocarditis, Non-Infective, cardiovascular system, Cardiology, Duodenum, Mitral Valve, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

A 73-year-old women visited emergency department because of sudden right hemiplegia. She had a history of duodenum papilla cancer terminal stage and multiple liver metastasis. On admission, diffusion weighted images revealed high intensity area at left middle cerebral artery territory. In addition, 3D-TOF MRA depicted proximal part of the left internal carotid artery. We performed endovascular thrombectomy because low platelet count met contraindication of intravenous recombinant tissue plasminogen activator therapy. Although we could get partial recanalization of middle cerebral artery occlusion after thrombectomy, the patient eventually died due to multiple organ failure. Autopsy findings showed white thrombus on mitral valve and also left middle cerebral artery occluded by similar white thrombus without infective findings. The patient was finally diagnosed with nonbacterial thrombotic endocarditis due to white thrombus on the mitral valve. We should select appropriate mechanical thrombectomy devices with a case of cerebral infarction due to nonbacterial thrombotic endocarditis because its thrombus is often white thrombus and would be hard.

Published
2019
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39. Weak ferromagnetism derived from spin canting in an amido-bridged homochiral Mn(<scp>iii</scp>) 1-D coordination polymer

Author

Atsushi Koga, Fumiya Kobayashi, Ryo Ohtani, Leonard F. Lindoy, Yang Kim, Masaaki Nakamura, Sotaro Kusumoto, and Shinya Hayami

Subjects
Phase transition, Materials science, 010405 organic chemistry, Coordination polymer, Ligand, Crystal structure, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, Crystallography, chemistry.chemical_compound, Ferromagnetism, chemistry, Antiferromagnetism, Methylene, Spin canting
Abstract

A homochiral one-dimensional (1D) Mn(III) coordination polymer [MnL]n (1) was synthesised employing the N3O-donor tetradentate ligand (L = 2-hydroxy-N-[2-[[(2-aminophenyl)methylene]amino]-2-methylpropyl]-benzamide). The X-ray structure of 1 and its magnetic properties were investigated in detail. The crystal structure of 1 shows a homochiral helical arrangement in which spontaneous resolution has occurred, despite the ligand being achiral. Magnetic characterization revealed an antiferromagnetic interaction between manganese(III) ions (J = −2.48 cm−1, g = 1.96) that leads to an antiferromagnetic spin-ordering phase transition at TN ≈ 7 K. Noteworthily, 1 exhibits weak ferromagnetism with a relatively large coercive field of 3.0 kOe based on the spin canting, indicating the formation of a homochiral weak ferromagnet.

Published
2019
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41. Consecutive oxidative additions of iodine on undulating 2D coordination polymers: formation of I–Pt–I chains and inhomogeneous layers

Author

Masaaki Sadakiyo, Leonard F. Lindoy, Ryo Ohtani, Jenny Pirillo, Riho Yamamoto, Yuh Hijikata, Hiroyoshi Ohtsu, Shinya Hayami, and Masaki Kawano

Subjects
chemistry.chemical_classification, Materials science, 010405 organic chemistry, Polymer, 010402 general chemistry, Antibonding molecular orbital, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, Crystallography, symbols.namesake, Zigzag, chemistry, Absorption band, Perpendicular, symbols, Raman spectroscopy, Powder diffraction, Excitation
Abstract

The 2D coordination polymers, [Mn(salen)]2[PtII(CN)4]1-x[PtIV(CN)4(I2)]x (salen = N,N'-ethylenebis(salicylideneaminato), x = 0.18 (1), 0.45 (2), 0.85 (3)), have been synthesized via consecutive oxidative additions of iodine to the 2D undulating layers in [Mn(salen)]2[PtII(CN)4]. The presence of I-Pt-I chains perpendicular to the layers and the inhomogeneity of individual I-Pt-I sites were demonstrated. The I-Pt-I chains in 3 give rise to an absorption band involving the excitation that arises from an antibonding nature orbital to the corresponding bonding nature orbital between iodides in the I-Pt-I bridging units. Moreover, variable-temperature X-ray powder diffraction patterns and Raman spectra for 1 and 2 indicate that some I-Pt-I sites display different vibrational energies that are associated with the contraction of the zigzag 2D layers.

Published
2019
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42. Crystalline assembly of metal-organic polyhedra driven by ionic interactions with polyoxometalates

Author

Ryo Ohtani, Masaaki Ohba, Benjamin Le Ouay, Yuta Ohtsubo, Haruka Yoshino, and Kenta Sasaki

Subjects
Zirconium, animal structures, Hydrazine, Metals and Alloys, Cationic polymerization, chemistry.chemical_element, Ionic bonding, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, MOPS, Metal, chemistry.chemical_compound, chemistry, Chemical engineering, visual_art, Materials Chemistry, Ceramics and Composites, visual_art.visual_art_medium, Reactivity (chemistry), sense organs, Porosity
Abstract

Charge-driven self-assembly of cationic zirconium-based metal–organic polyhedra (MOPs) with polyoxometalates (POMs) leads to a series of porous crystalline salts, prepared by simple mixing of soluble precursors. The reactivity of immobilized POMs was greatly increased, as demonstrated by their fast reduction by hydrazine vapors, without loss of structural integrity.

Published
2021

43. Node Distortion Modulation for Anisotropic Thermal Expansions of Two‐dimensional Coordination Polymers

Author

Junichi Yanagisawa, Ryo Ohtani, Benjamin Le Ouay, and Masaaki Ohba

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Coordination polymer, Jahn–Teller effect, Energy Engineering and Power Technology, Molecular physics, Thermal expansion, Biomaterials, chemistry.chemical_compound, chemistry, Modulation, Distortion, Thermal, Node (physics), Materials Chemistry, Anisotropy
Published
2021
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44. Theoretical investigation of tetrahedral distortion of four-coordinate iron(II) centres in FePd(CN)

Author

Susumu, Fujii, Ryo, Ohtani, and Akihide, Kuwabara

Abstract

The tetrahedral distortion of iron(ii) centres in the cyanide-bridged framework FePd(CN)4 was recently demonstrated experimentally. Here, we theoretically confirmed the electronically driven tetrahedral distortion of iron(ii) by comparing the density of states and total energies of FePd(CN)4 (d6) and ZnPd(CN)4 (d10). The calculation results suggested that a Jahn-Teller-like effect is caused on the tetrahedral geometry by the electronic effect of unequally occupied non-bonding 3d orbitals in the corresponding structure.

Published
2021

46. [A case of oculomotor disorder and urinary retention due to a lower midbrain lesion]

Author

Ryo Ohtani, Makoto Sainouchi, Michikazu Nakamura, and Yuichi Masuda

Subjects
genetic structures, media_common.quotation_subject, Infarction, Urination, Oculomotor nucleus, Lesion, Ocular Motility Disorders, Mesencephalon, Diplopia, Medicine, Humans, Periaqueductal Gray, media_common, Aged, 80 and over, business.industry, Urinary retention, Medial rectus muscle, Cerebral Infarction, Urinary Retention, medicine.disease, Binocular Diplopia, Diffusion Magnetic Resonance Imaging, Anesthesia, Female, Neurology (clinical), medicine.symptom, business
Abstract

We report an 86-year-old woman who suffered sudden onset of diplopia while cooking. The patient presented with binocular diplopia, bilateral adduction weakness, convergence disorder and bilateral abduction nystagmus. Although brain MRI on admission detected no abnormality, a repeat MRI examination on the following day demonstrated a focal hyperintense lesion in the tegmentum of the midbrain on diffusion-weighted images. At 36 hours after admission, lower abdominal distension became apparent, and about 1 liter of urine was drained via a urethral catheter. Bladder filling sensation was not present, and we considered that the midbrain lesion had been responsible for the oculomotor disorder and urinary retention. As cerebral infarction was the most likely pathology of this lesion, an antiplatelet agent was administered. At two months after onset, the eye movement disorder was resolved and there was no diplopia. Bladder voiding also resumed at normal intervals. We considered that the bilateral medial longitudinal fasciculi and subgroups of the oculomotor nucleus, which contain motor neurons supplying the medial rectus muscle, had been responsible for the oculomotor disorder. The urinary retention was thought to have been caused by a lesion in the periaqueductal gray, which is one structure controlling micturition. This was a rare case of urinary retention due to a small midbrain infarction.

Published
2020

47. Luminescent ionic liquid formed from a melted rhenium(v) cluster

Author

Ryo Ohtani, Genki Kobayashi, Fumiya Kobayashi, Daisuke Saito, Masaki Yoshida, Junichi Yanagisawa, Tomoaki Hiraoka, Shinya Hayami, Masaaki Ohba, Masako Kato, Leonard F. Lindoy, and Fumitaka Takeiri

Subjects
Materials science, Metals and Alloys, chemistry.chemical_element, General Chemistry, Rhenium, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Metal, Crystallography, chemistry.chemical_compound, chemistry, visual_art, Phase (matter), Ionic liquid, Materials Chemistry, Ceramics and Composites, visual_art.visual_art_medium, Cluster (physics), Luminescence, Supercooling
Abstract

Recently, non-crystalline coordination materials have been shown to represent a versatile class of functional materials. However, such materials incorporating metal complex clusters have remained largely unexplored. Herein, we demonstrate that a luminescent tetranuclear ReV cluster melts at 489 K, with the cluster structure being maintained in the corresponding supercooled ionic liquid phase.

Published
2020

48. Responsive Four-Coordinate Iron(II) Nodes in FePd(CN)

Author

Ryo, Ohtani, Hiromu, Matsunari, Takafumi, Yamamoto, Koji, Kimoto, Masaaki, Isobe, Kotaro, Fujii, Masatomo, Yashima, Susumu, Fujii, Akihide, Kuwabara, Yuh, Hijikata, Shin-Ichiro, Noro, Masaaki, Ohba, Hiroshi, Kageyama, and Shinya, Hayami

Abstract

Metal node design is crucial for obtaining structurally diverse coordination polymers (CPs) and metal-organic frameworks with desirable properties; however, Fe

Published
2020

49. Pseudo-Membrane Jackets: Two-Dimensional Coordination Polymers Achieving Visible Phase Separation in Cell Membrane

Author

Kenichi Kawano, Koichi Kato, Nobuaki Matsumori, Hiroshi Uji-i, Masanao Kinoshita, Masaaki Ohba, Shinya Hayami, Kenji Hirai, Shiroh Futaki, Hikaru Watanabe, Saeko Yanaka, and Ryo Ohtani

Subjects
Coordination polymer, Polymers, CHO Cells, 010402 general chemistry, 01 natural sciences, Catalysis, Nanomaterials, Cell membrane, chemistry.chemical_compound, Cricetulus, medicine, Animals, Actin, chemistry.chemical_classification, 010405 organic chemistry, Cell Membrane, General Chemistry, Polymer, Actin cytoskeleton, 0104 chemical sciences, Membrane, medicine.anatomical_structure, chemistry, Biophysics, Thermodynamics, Metal-organic framework
Abstract

Cell membranes contain lateral systems that consist of various lipid compositions and actin cytoskeleton, providing two-dimensional (2D) platforms for chemical reactions. However, such complex 2D environments have not yet been used as a synthetic platform for artificial 2D nanomaterials. Herein, we demonstrate the direct synthesis of 2D coordination polymers (CPs) at the liquid-cell interface of the plasma membrane of living cells. The coordination-driven self-assembly of networking metal complex lipids produces cyanide-bridged CP layers with metal ions, enabling "pseudo-membrane jackets" that produce long-lived micro-domains with a size of 1-5 μm. The resultant artificial and visible phase separation systems remain stable even in the absence of actin skeletons in cells. Moreover, we show the cell application of the jackets by demonstrating the enhancement of cellular calcium response to ATP.

Published
2020

50. Positive and Negative Two-Dimensional Thermal Expansion via Relaxation of Node Distortions

Author

Takuya Aoyama, Ryo Ohtani, Shinya Hayami, Jack K. Clegg, Arnaud Grosjean, Riho Yamamoto, and Masaaki Nakamura

Subjects
010405 organic chemistry, Plane (geometry), Chemistry, Relaxation (NMR), 010402 general chemistry, 01 natural sciences, Thermal expansion, 0104 chemical sciences, Inorganic Chemistry, Negative thermal expansion, Zigzag, Chemical physics, Thermal, Node (physics), Physical and Theoretical Chemistry, Anisotropy
Abstract

The ability to tune physical properties is attractive for the development of new materials for myriad applications. Understanding and controlling the structural dynamics in complicated network structures like coordination polymers (CPs) is particularly challenging. We report a series of two-dimensional CPs [Mn(salen)]2[M(CN)4]·xH2O (M = Pt (1), PtI2 (2), and MnN (3)) incorporating zigzag cyano-network layers that display composition-dependent anisotropic thermal expansion properties. Variable-temperature single-crystal X-ray structural analyses demonstrated that the thermal expansion behavior is caused by double structural distortions involving [Mn(salen)]+ units incorporated into the zigzag layers. Thermal relaxations produce structural transformations resulting in positive thermal expansion for 2·H2O and negative thermal expansion for 3. In the case of 1·H2O, the relaxation does not occur and zero thermal expansion results in the plane between 200 to 380 K. The present study proposes a new strategy base...

Published
2018
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