486 results on '"Rueda B"'
Search Results
2. Polymorphisms in the interleukin 4, interleukin 13 and corresponding receptor genes are not associated with Systemic Sclerosis and do not influence gene expression
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Aliprantis A, Coenen MJH, Airò P, Gonzalez-Gay M A, Ortego-Centeno N, Carreira P, Fonollosa V, Scorza R, Simeon C P, Kiener H, Riemekasten G, Hunzelmann N, Worthington J, Herrick A, Rueda B, Beretta L, Vonk M C, Dieude P, Broen JCA, Martin J, Allanore Y, and Radstake TRDJ
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Medicine - Published
- 2010
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3. A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort
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Airó P, Lie B A, Palm Ø, Nordin A, Padykov L, Claes K, Denton C, Fonseca C, Madhok R, Shiels P, Chee M M, Schuerwegh A J, Voskuyl A E, De Langhe E, Westhovens R, Smith V, De Keyser F, Houssiau F, Koeleman B P, Coenen MJH, Witte T, Riemekasten G, Hesselstrand R, González-Gay M A, Pros A, García de la Peña P, Follonosa V, Egurbide M V, Fernández-Nebro A, Gallego M, Castellví I, García-Hernández F J, Gómez-Gracia I, Román-Ivorra J A, Tolosa C, Rodríguez L, Vicente-Rabaneda E, González-Escribano M F, Navarrete N, Camps M T, Carreira P, Espinosa G, Ortego-Centeno N, Vonk M C, Beretta L, Simeon C P, Broen JCA, Bossini-Castillo L, Scorza R, van Laar J M, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Radstake TRDJ, Martín J, and Rueda B
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Medicine - Published
- 2010
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4. Association study of functional genetic variants of innate immunity related genes in celiac disease
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Martín J, López-Nevot MA, Zhernakova A, Rueda B, and Koeleman BPC
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Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD) pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition. Methods We performed a familial study in which 105 celiac families characterized by the presence of an affected child with CD were genotyped for functional polymorphisms located at regulatory regions of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes. Familial data was analysed with a transmission disequilibrium test (TDT) that revealed no statistically significant differences in the transmission pattern of the different genetic markers considered. Results The TDT analysis for IL-1α, IL-1β, IL-1RN, IL-18, and MCP-1 genes genetic variants did not reveal biased transmission to the affected offspring. Only a borderline association of RANTES promoter genetic variants with CD predisposition was observed. Conclusion Our results suggest that the analysed polymorphisms of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes do not seem to play a major role in CD genetic predisposition in our population.
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- 2005
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5. Forecasting of refractory wall thickness in an electric arc furnace used in ferro-nickel production
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Gomez, R., primary, Rueda, B., additional, Romero, J., additional, Pedraza, C., additional, Sofrony, J., additional, Mantilla, J., additional, and Tibaduiza, D., additional
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- 2024
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6. Temperature forecasting against sensors failures in an electric arc furnace
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Godoy, D., primary, Rueda, B., additional, Romero, J., additional, Leon, J., additional, and Tibaduiza, D., additional
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- 2024
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7. Data-driven flow cytometry classification of blast differentiation in older patients with acute myeloid leukemia
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Rojas, F., Longoni, H., Milone, G., Fernández, I., Conciencia, Clínica, Ramirez, R., Canepa, C., Saba, S., Balladares, G., Ventiurini, C., Mariano, R., Negri, P., Prates, M.V., Milone, J., Fazio, P., Gelemur, M., Ciarlo, S., Bezares, F., López, L., García, J. J, Giunta, M., Kruss, M., Lafalse, D., Marquesoni, E., Casale, M.F., Gimenez, A., Brulc, E.B., Perusini, M.A., Palmer, L., Correa, M.E., Jaramillo, F.J., Rosales, J., Sossa, C., Herrera, J.C., Arango, M., Holojda, J., Golos, A., Ejduk, A., Ochrem, B., Małgorzata, G., Waszczuk-Gajda, A., Drozd-Sokolowska, J., Czemerska, M., Paluszewska, M., Zarzycka, E., Masternak, A., Hawrylecka, Dr., Podhoreka, M., Giannopoulos, K., Gromek, T., Oleksiuk, J., Armatys, bA., Helbig, G., Sobas, M., Szczepaniak, A., Rzenno, E., Rodzaj, M., Piatkowska-Jakubas, B., Skret, A., Pluta, A., Barańska, E., Vasconcelos, G., Brioso, J., Nunes, A., Bogalho, I., Espadana, A., Coucelo, M., Marini, S., Azevedo, J., Crisostomo, A.I., Ribeiro, L., Pereira, V., Botelho, A., Mariz, J.M., Guimaraes, J.E., Aguiar, E., Coutinho, J., Noriega, V., García, L., Varela, C., Debén, G., González, M.R., Encinas, M., Bendaña, A., González, S., Bello, J.L., Albors, M., Algarra, L., Romero, J.R., Bermon, J.S., Varo, M.J., López, V., López, E., Mora, C., Amorós, C., Romero, A., Jaramillo, A., Valdez, N., Molina, I., Fernández, A., Sánchez, B., García, A., Castaño, V., López, T., Bernabeu, J., Sánchez, M.J., Fernández, C., Gil, C., Botella, C., Fernández, P., Pacheco, M., Tarín, F., Verdú, J.J., García, M.J., Mellado, A., García, M.C., González, J., Castillo, T., Colado, E., Alonso, S., Recio, I., Cabezudo, M., Davila, J., Rodríguez, M.J., Barez, A., Díaz, B., Prieto, J., Arnan, M., Marín, C., Mansilla, M., Balaberdi, A., Amutio, M.E., del Orbe, R.A., Ancin, I., Ruíz, J.C., Olivalres, M., Gómez, C., gonzález, I., Celis, M., Atutxa, K., Carrascosa, T., Artola, T., Lizuain, M., Rodriguez, J .I., Arce, O., Márquez, J.A., Atuch, J., Marco de Lucas, F., Díez, Z., Dávila, B., Cantalejo, R., Díaz, M., Labrador, J., Serra, F., Hermida, G., Díaz, F.J., de Vicente, P., Álvarez, R., Alonso, C., Bergua, J.M., Ugalde, N., Pardal, E., Saldaña, R., Rodríguez, F., Martín, E., Hermosín, L., Garrastazul, M.P., Marchante, I., Raposo, J.A., Capote, F.J., Colorado, M., Batlle, A., Yañez, L., García, S., González, P., Ocio, E.M., Briz, M., Bermúdez, A., Jiménez, C., Beltrán, S., Montagud, M., Castillo, I., García, R., Gascón, A., Clavel, J., Lancharro, A., Lnares, L., Herráez, M.M., Milena, A., Romero, M.J., Hernández, B., Calle, C., Benegas, R., Bolívar, Dr., Serrano, J., Dorado, F.J., Sánchez, J., Martínez, M.C., Cerveró, C.J., Busto, M.J., Bernal, M., Moratalla, L., Mesa, Z., Jurado, M., De Miguel, D., Santos, A.B., Arbeteta, J., Pérez, E., Caminos, N., Uresandi, N., Argoitiaituart, N., Swen, J., Uranga, A., Olazaba, I., Gainza, E., Romero, P., Gil, E., Palma, A.J., Gómez, K.G., Solé, M., Rodríguez, J.N., Murillo, I.M., Marco, J., Serena, J., Marco, V., Perella, M., Costilla, L., López, J.A., Baena, A., Almagro, P., Hermosilla, M., Esteban, A., Campeny, B.A., Nájera, M.J., Herrra, P., Fernández, R., González, J.D., Torres, L., Jiménez, S., Gómez, M.T., Bilbao, C., Rodríguez, C., Hong, A., Ramos de Laón, Y., Afonso, V., Ramos, F., Fuertes, M., de Cabo, E., Aguilera, C., Megido, M., García, T., Lavilla, E., Varela, M., Ferrero, S., Arias, J., Vizcaya, L., Roldán, A., Vilches, A., Penalva, M.J., Vázquez, J., Calderón, M.T., Matilla, A., Serí, C., Otero, M.J., García, N., Sandoval, E., Franco, C., Flores, R., Bravo, P., López, A., López, J.L., Blas, C., Díez, A., Alonso, J.M., Soto, C., Arenas, A., García, J., Martín, Y., Villafuerte, P.S., Magro, E., Bautista, G., De Laiglesia, A., Rodríguez, G., Solán, L., Chicano, M., Balsalobre, P., Monsalvo, S., Font, P., Carbonell, D., Martínez, C., Humala, K., Kerguelen, A.E., Hernández, D., Gasior, M., Gómez, P., Sánchez, I., Redondo, S., Llorente, L., Bengochea, M., Pérez, J., Sebrango, A., M. santero, Morales, A., Figuera, A., Villafuerte, P., Alegre, A., Fernández, E., Alonso, A., Martínez, M.P., Martínez, J., Cedena, M.T., Moreno, L., De la Fuente, A., García, D., Chamorro, C., Pradillo, V., Martí, E., Sánchez, J.M., Delgado, I., Rosado, B., Velasco, A., Miranda, C., Salvatierra, G., Foncillas, M., Hernández, J.A., Escolano, C., Benabente, C., Martínez, R., Polo, M., Anguita, E., Riaza, R., Amores, G., Requena, M.J., Javier, F., Villaloón, L., Aláez, C., Nistal, S., Navas, B., Andreu, M.A., Herrera, P., López, J., García, M., Moreno, M.J., Queipo, M.P., Hernández, A., Barrios, M., Heiniger, A., Jiménez, A., Contento, A., López, F., Alcalá, M., Lorente, S., González, M., Morales, E.M., Gutierrez, J., Serna, M.J., Beltrán, V., Romera, M., Berenguer, M., MArtínez, A., Tejedor, A., Amigo, M.L., Ortuño, F., Jerez, A., López, O., Moraleda, J.M., Rosique, P., Gómez, J., Garay, M.C., Cerezuela, P., MArtínez, A.B., González, A., Ibáñez, J., Alfaro, M.J., Mateos, M., Goñi, M.A., Araiz, M.A., Gorosquieta, A., Zudaire, M., Viguria, M., Zabala, A., Alvarellos, M., Quispe, I., Sánchez, M.P., Hurtado, G., Pérez, M., Burguete, Y., Areizaga, N., Galicia, T., Rifón, J., Alfonso, A., Prósper, F., Marcos, M., Tamariz, L.E., Riego, V., Manubens, A., Larrayoz, M.J., Calasanz, M.J., Mañú, A., Paiva, B., Vázquez, I., Burgos, L., Pereiro, M., Rodríguez, M., Pastoriza, M.C., Mendez, J.A., Sastre, J.L., Iglesias, M., Ulibarrena, C., Campoy, F., Jaimes, D., Albarrán, B., Solano, J., Silvestre, A., Albo, C., Suarez, S., Loureiro, C., Figueroa, I., Fernández, M.A., Martínez, A., Poderós, C., Vazquez, J., Iglesias, L., Nieto, A., Torrado, T., Martínez, A.M., Amador, M.L., Oubiña, P., Feijó, E., Dios, A., Loyola, I., Roreno, R., Simiele, A., Álvarez, L., Turcu, V., Vidriales, B., Avendaño, A., Chillón, C., González, V., Govantes, J.V., Rubio, S., Tapia, M., Olivier, C., Queizán, J.A., Pérez, O., Vera, J.A., Muñoz, C., rodriguez, A., González, N., Pérez, J.A., Soria, E., I.Espigado, Falantes, J., Montero, I., García, P., Rodríguez, E., Carrillo, E., Caballero, T., García, C., Couto, C., Simón, I., Gómez, M., Aguilar, C., González, B.J., Lakhwani, S., Bienert, A., González, B., Cabello, A., Oliva, A.Y., González, H., Sancho, L., Paricio, M., Perdiguer, L., Solano, F., Lerma, A., Martínez, M.D., Gómez, M.I., Yeguas, A., Montesinos, P., Barragán, E., Sargas, C., Amigo, R., Martinez, D., Boluda, B., Rodríguez, R., Acuña, E., Cano, I., Escrivá, A., Pedreño, M., Navalón, A., Orts, M., Sayas, M.J., Fernández, M.J., Juan, M.L., Gómez, E., Gimeno, M., Donato, E., Cejalvo, M., Tormo, M., Calabuig, M., Navarro, B., Martin, I., Villamont, E., Miralles, A., Lluch, R., Moragues, M., Ruiz, M.A., Benet, C., Valero, M., Linares, M., Collado, R., Orero, M., Ibañez, P., Lis, M.J., Pérez, P.L., Roig, M., López, M., Mena, A.V., Picón, I., Cánovas, V., Palacios, A., Cuello, R., Borrego, J., burgois, M., Cantalapiedra, A., Norberto, O., Angomas, E., Cidoncha, B., Cuevas, L., Robles, D., Mendiazabal, A., Oiartzabal, I., Guinea de Castro, J.M., Montes, C., Carrasco, V., Pérez, A., Moneva, J.J., Olave, M., Bonafonte, E., Mayor, L., Azaceta, G., Palomera, L., Malo, M., Escobar, M.J., Grasa, J.M., De Rueda, B., Aulés, A., Salvador, C., Ansó, V., Iborra, A., Delagado, P., Rubio, A., Stevenazzi, M., Alpire, I., Irigoin, V., Díaz, L., Guillermo, C., Guadagna, R., Grille, S., Oliver, C., Boada, M., Vales, V., Prado, A.I., De los Santos, A.P., Simoes, Catia, Gonzalez, Carmen, Vergez, François, Sarry, Audrey, Bertoli, Sarah, Ariceta, Beñat, Martínez-Cuadrón, David, Bergua, Juan-Miguel, Vives, Susana, Algarra, Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez-Lorenzo, Jose-Luis, Vidriales, Maria-Belen, Chillon, Carmen, Labrador, Jorge, Falantes, Jose-Francisco, Sayas, María-José, Ayala, Rosa, Martinez-Lopez, Joaquin, Villar, Sara, Calasanz, Maria-Jose, Prosper, Felipe, San-Miguel, Jesús F., Sanz, Miguel Á., Récher, Christian, Paiva, Bruno, and Montesinos, Pau
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- 2024
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- View/download PDF
8. Forecasting of refractory wall thickness in an electric arc furnace used in ferro-nickel production
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Gomez, R., primary, Rueda, B., additional, Romero, J., additional, Pedraza, C., additional, Sofrony, J., additional, Mantilla, J., additional, and Tibaduiza, D., additional
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- 2023
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9. Temperature forecasting against sensors failures in an electric arc furnace
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Godoy, D., primary, Rueda, B., additional, Romero, J., additional, Leon, J., additional, and Tibaduiza, D., additional
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- 2023
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10. Invasive treatment trends in urinary calculi in a third level hospital
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García-Galisteo, E., Sánchez-Martínez, N., Molina-Díaz, P., López-Rueda, B., and Baena-González, V.
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- 2015
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11. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction
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Chiu, Y -H, Karmon, A E, Gaskins, A J, Arvizu, M, Williams, P L, Souter, I, Rueda, B R, Hauser, R, and Chavarro, J E
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- 2018
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12. The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database
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Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, 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G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. 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F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, and Citerio G
- Abstract
Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
- Published
- 2020
13. NOVEDADES EN EAS:FROM BENCH TO BEDSIDE.
- Author
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Martín, Javier, Márquez, Ana, Martín, Adoración, Callejas-Rubio, José Luis, Rueda, B., Montero, Eva, Martín, Javier, Márquez, Ana, Martín, Adoración, Callejas-Rubio, José Luis, Rueda, B., and Montero, Eva
- Published
- 2022
14. Identification of LMX1B as a novel oncogene in human ovarian cancer
- Author
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He, L, Guo, L, Vathipadiekal, V, Sergent, P A, Growdon, W B, Engler, D A, Rueda, B R, Birrer, M J, Orsulic, S, and Mohapatra, G
- Published
- 2014
- Full Text
- View/download PDF
15. The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
- Author
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Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Université libre de Bruxelles (ULB), Belfast City Hospital, Department Intensive Care Medicine, Center of Infectious Diseases, Radboudumc, Nijmegen, The Netherlands., University of Bern [Bern, Switzerland] (University Hospital Bern ), Universität Augsburg [Augsburg], Prince Sultan university (saudi Arabia), Riyadh, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Assistance Publique - Hôpitaux de Marseille (APHM), Mayo Clinic, Jena University Hospital [Jena], Supporting clinical sciences, Intensive Care, Internal Medicine Specializations, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Vincent, J. -L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., Leone, M., Mokhtari, M., Fontes, L. E., Bauer, P. R., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M. N., Nica, A., Stoica, R., Tomescu, D. R., Constantinescu, D. L., Valcoreanu Zbaganu, G. M., Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X. Z., Zhao, X., Li, C. H., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T. H., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Li, C., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W. L., Sin, K. K. C., Lee, K. L., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T. T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. A. N., Tai, L. L., Tony, B., Bigornia, R. R., Palo, J. E., Chatterjee, S., Tan, B. H., Kong, A., Goh, S., Lee, C. -C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Nowruzinia, S., Lotfi, A. H., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A. Y., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H. K., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J. C., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R. G., Jimenez, E., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Hawkins, D. J., Kilminster, M., Sturgess, D., Ziegenfuss, M., O' Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M. M., D'Agostino Dias, M., Lunardi, M. C., Youssef, N. C., Lobo, S., Silva, R., Sales, J. A., Melo, L. M. C., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A. P., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Filho, R. C., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro Castro, L. F., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Villalba Gaviria, M. C., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Juan Francisco, L. L., Namendys-Silva, S. A., Moya, R. G., Hernandez, M., Rodriguez Cadena, D. M., Islas, I. L., Ballesteros Zarzavilla, C. M., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Mareque Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, G., Lahkar, B., Mandal, A. K., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe, K., Patel, M., Bhavsar, A., Samaddar, D. P., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K. -H., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J. J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Spapen, H., Van Collie, O., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V. -P., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M. -R., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. -Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Lepoivre, T., Moussa, M. D., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C. -J., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R. A., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S. O., Barry, J., O'Leary, R. A., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M. F., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J. J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, I., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M. A., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Perez Granda, M. J., Moreno, S., Llubia, C., Martos, C. D. L. F., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Quindos, B., Quintano, A., Tebar, M. T., Cardinal, P., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J. A., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Matthew, S., Downes, R., Groba, C. 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Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, and Gowda, K
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Male ,umrljivost ,medicine.medical_treatment ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,udc:616.1/.4 ,Critical Care and Intensive Care Medicine ,urologic and male genital diseases ,akutna ledvična odpoved ,renal insufficiency ,law.invention ,0302 clinical medicine ,law ,Oliguria ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Prospective Studies ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,oligurija ,nadomestno zdravljenje ledvične odpovedi ,Acute Kidney Injury ,Middle Aged ,kidney diseases ,Intensive care unit ,urine ,3. Good health ,urine output ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Mortality, Renal replacement therapy, Urine output ,Female ,oliguria ,medicine.symptom ,renal replacement therapy ,Adult ,kidney ,medicine.medical_specialty ,oskrba kritično bolnih ,urin ,Critical Illness ,610 Medicine & health ,Statistics, Nonparametric ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,acute kidney failure ,medicine ,critical illness ,Humans ,Clinical significance ,In patient ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,ddc:610 ,Renal replacement therapy ,izločanje urina ,Mortality ,Urine output ,Aged ,Observational database ,Analysis of Variance ,Critically ill ,business.industry ,Research ,renalna insuficienca ,Médecine pathologie humaine ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,mortality ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,critical care ,bolezni ledvic ,Emergency medicine ,kritično stanje ,ledvica ,business - Abstract
BackgroundUrine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis.ResultsOf the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient—oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged—oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent—oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19–1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97–1.34], p = 0.103).ConclusionsOliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome., 0, info:eu-repo/semantics/published
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- 2019
16. A new case of bacterial endocarditis in a child with severe Haemophilia A carrying a central venous access device
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De Rueda, B., Santa Catalina, S., Lucia, F., García de la Calzada, D., and Aguilar, C.
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- 2015
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17. t(1;19)(q23;p13) TCF3-PBX1 May Not Be an Intermediate-Risk Subtype in Adult B-Cell Precursor Acute Lymphoblastic Leukemia Patients Treated With MRD-Oriented Protocols from the PETHEMA Group
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Ribera, J, Morgades, M, Granada, I, Torrent, A, Zamora, L, Gonzalez, T, Ciudad, J, Barrena, S, Such, E, Avetisyan, G, Calasanz, MJ, Genesca, E, Gonzalez-Gil, C, Fuster-Tormo, F, Mercadal, S, Maluquer, C, Coll, R, Gonzalez-Campos, J, Tormo, M, Garcia-Cadenas, I, Nomdedeu, J, Gil, C, Cervera, M, Escoda, L, Montesinos, P, Barba, P, Esteve, J, Diaz-Beya, M, Martinez-Sanchez, P, Martinez-Lopez, J, Novo, A, Queipo, MP, Bermudez, A, Bergua, J, Olave, MT, de Rueda, B, Artola, MT, Hernandez-Rivas, JM, Orfao, A, and Ribera, JM
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TCF3-PBX1 ,PETHEMA ,outcome ,MRD-oriented trials ,acute lymphoblastic leukemia - Published
- 2021
18. Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
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Vincent, J. -L., Lefrant, J. -Y., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S. G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Židková, A., Lavicka, P., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Kolbusz, J., Kübler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Valcoreanu Zbaganu, G., Slavcovici, A., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Cohen, J., Sold, O., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J. L., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. 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C., Raemaekers, J., Roman, A., Simon, M., Spapen, H., Swinnen, W., Vallot, F., Chytra, I., Herold, I., Polak, F., Sterba, M., Bestle, M., Espersen, K., Guldager, H., Welling, K. -L., Nyman, D., Ruokonen, E., Annane, D., Catogni, P., Colas, G., Coulomb, F., Dorne, R., Garrouste, M., Isetta, C., Larché, J., LeGall, J. -R., Lessire, H., Malledant, Y., Mateu, P., Ossart, M., Schlossmacher, P., Timsit, J. -F., Winnock, S., Sollet, J. -P., Mallet, L., Maurer, P., Sab, J. M., Sollet, J. P., Aykut, G., Brunkhorst, F., Lauterbach, M., Ragaller, M., Gatz, R., Gerlach, H., Henzler, D., Hopf, H. -B., Hueneburg, H., Karzai, W., Keller, A., Bauer, T., Kuhlmann, U., Langgartner, J., Manhold, C., Reith, B., Schuerholz, T., Spies, C., Stögbauer, R., Unterburger, J., Clouva-Molyvdas, P. -M., Giokas, G., Ioannidou, E., Lahana, A., Liolios, A., Marathias, K., Tasiou, A., Tsangaris, H., Marsh, B., Power, M., Sprung, C., Biagioli, B., Bobbio Pallavicini, F., Pesenti, A., Della Corte, F., Donadio, P. P., Donati, A., Giorgio, T., Giudici, D., Greco, S., Guadagnucci, A., Lapichino, G., Livigni, S., Moise, G., Nardi, G., Panascia, E., Pizzamiglio, M., Ranieri, V. M., Rosi, R., Sicignano, A., Solca, M., Vignali, G., Volpe Rinonapoli, I., Barnas, M., De Bel, E. E., De Pont, A. -C., Groeneveld, J., Nijsten, M., Sie, L., Zandstra, D. F., Harboe, S., Lindén, S., Lovstad, R. Z., Moen, H., Smith-Erichsen, N., Piotrowski, A., Karpel, E., Pais-De-Lacerda, A., Paiva, J. A., Pimentel, A., Jovanovic, K., Malik, P., Lucka, K., Aldecoa Alvarez-Santullano, C., Artigas, A., Escorsell, A., Nicolas, J., Izura Cea, J. J., Montejo, J., Palencia, E., Santos, F., Sierra-Camerino, R., Sipmann, F., Brodersen, K., Haggqvist, J., Hermansson, D., Hjelmqvist, H., Loderer, G., Maggiorini, M., Andrews, P., Appadu, B., Bewley, J., Burchett, K., Chambers, P., Coakley, J., Doberenz, D., Eastwood, N., Fielden, J., Gedney, J., Gunning, K., Harling, D., Jankowski, S., Jayson, D., Kilner, A., Krishna-Kumar, V., Lei, K., Mackenzie, S., Macnaughton, P., McCulloch, C., Morgan, P., Rhodes, A., Roberts, C., Russell, M., Tupper-Carey, D., Wright, M., Twohey, L., Watts, J., Webster, R., Williams, D., on behalf of the ICON and SOAP investigators and SOAP investigators, Vincent, J.-L., Lefrant, J.-Y., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S.G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Židková, A., Lavicka, P., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Kolbusz, J., Kübler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Valcoreanu Zbaganu, G., Slavcovici, A., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Cohen, J., Sold, O., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J.L., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J.Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Giannakou Peftoulidou, M., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Barry, J., O’Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Vintém De Oliveira, A., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nóbrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Kerin Povšic, M., Osojnik, I., Tomic, V., Sinkovic, A., González, J., Zavala, E., Pérez Valenzuela, J., Marina, L., Vidal-Cortés, P., Posada, P., Ignacio Martin-Loeches, A., Muñoz Guillén, N., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M., Aguilar, G., Montoiro Allué, R., Argüeso, M., Parejo, M., Palomo Navarro, M., Jose, A., Nin, N., Alvarez Lerma, F., Martinez, O., Tenza Lozano, E., Arenal López, S., Perez Granda, M., Moreno, S., Llubia, C., De La Fuente Martos, C., Gonzalez-Arenas, P., Llamas Fernández, N., Gil Rueda, B., Estruch Pons, I., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Iglesias Fraile, L., Quindos, B., Quintano, A., Tebar, M., Cardinal, P., Reyes, A., Rodríguez, A., Abella, A., García Del Valle, S., Yus, S., Maseda, E., Berezo, J., Tejero Pedregosa, A., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodríguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Barrera Groba, C., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Delle Karth, G., Draxler, V., Filzwieser, G., Heindl, W., Kellner, G., Lenz, K., Rossmann, E., Wiedermann, C., Chochrad, D., Damas, P., Decruyenaere, J., Hoste, E., Devriendt, J., Espeel, B., Installe, E., Malbrain, M., Nollet, G., Preiser, J.C., Raemaekers, J., Roman, A., Simon, M., Spapen, H., Swinnen, W., Vallot, F., Chytra, I., Herold, I., Polak, F., Sterba, M., Bestle, M., Espersen, K., Guldager, H., Welling, K.-L., Nyman, D., Ruokonen, E., Annane, D., Catogni, P., Colas, G., Coulomb, F., Dorne, R., Garrouste, M., Isetta, C., Larché, J., LeGall, J.-R., Lessire, H., Malledant, Y., Mateu, P., Ossart, M., Schlossmacher, P., Timsit, J.-F., Winnock, S., Sollet, J.-P., Mallet, L., Maurer, P., Sab, J.M., Sollet, J.P., Aykut, G., Brunkhorst, F., Lauterbach, M., Ragaller, M., Gatz, R., Gerlach, H., Henzler, D., Hopf, H.-B., Hueneburg, H., Karzai, W., Keller, A., Bauer, T., Kuhlmann, U., Langgartner, J., Manhold, C., Reith, B., Schuerholz, T., Spies, C., Stögbauer, R., Unterburger, J., Clouva-Molyvdas, P.-M., Giokas, G., Ioannidou, E., Lahana, A., Liolios, A., Marathias, K., Tasiou, A., Tsangaris, H., Marsh, B., Power, M., Sprung, C., Biagioli, B., Bobbio Pallavicini, F., Pesenti, A., Della Corte, F., Donadio, P.P., Donati, A., Giorgio, T., Giudici, D., Greco, S., Guadagnucci, A., Lapichino, G., Livigni, S., Moise, G., Nardi, G., Panascia, E., Pizzamiglio, M., Ranieri, V.M., Rosi, R., Sicignano, A., Solca, M., Vignali, G., Volpe Rinonapoli, I., Barnas, M., De Bel, E.E., De Pont, A.-C., Groeneveld, J., Nijsten, M., Sie, L., Zandstra, D.F., Harboe, S., Lindén, S., Lovstad, R.Z., Moen, H., Smith-Erichsen, N., Piotrowski, A., Karpel, E., Pais-De-Lacerda, A., Paiva, J.A., Pimentel, A., Jovanovic, K., Malik, P., Lucka, K., Aldecoa Alvarez-Santullano, C., Artigas, A., Escorsell, A., Nicolas, J., Izura Cea, J.J., Montejo, J., Palencia, E., Santos, F., Sierra-Camerino, R., Sipmann, F., Brodersen, K., Haggqvist, J., Hermansson, D., Hjelmqvist, H., Loderer, G., Maggiorini, M., Andrews, P., Appadu, B., Bewley, J., Burchett, K., Chambers, P., Coakley, J., Doberenz, D., Eastwood, N., Fielden, J., Gedney, J., Gunning, K., Harling, D., Jankowski, S., Jayson, D., Kilner, A., Krishna-Kumar, V., Lei, K., Mackenzie, S., Macnaughton, P., McCulloch, C., Morgan, P., Rhodes, A., Roberts, C., Russell, M., Tupper-Carey, D., Wright, M., Twohey, L., Watts, J., Webster, R., Williams, D., on behalf of the ICON and SOAP investigators and SOAP investigators, Université libre de Bruxelles (ULB), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), University of Wisconsin School of Medicine and Public Health, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Cliniques universitaires St Luc [Bruxelles], University Hospital of Cologne [Cologne], Radboud university [Nijmegen], Centro Hospitalar de Lisboa Central E.P.E, Intensive Care, Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Supporting clinical sciences, Other departments, CHU Lille, Université de Lille, Unité de réanimation médicale [CHU de Carémeau, Nîmes], West Pomeranian University of Technology Szczecin, Universität Witten Herdecke, Radboud University [Nijmegen], Faculdade de Medicina de São José do Rio Preto [FAMERP], Jena University Hospital [Jena], Vincent, J. -L., Lefrant, J. -Y., Sakka, S. G., Zidkova, A., Kubler, A., O'Leary, R., Vintem De Oliveira, A., Nobrega, J., Kerin Povsic, M., Gonzalez, J., Perez Valenzuela, J., Vidal-Cortes, P., Munoz Guillen, N., Montoiro Allue, R., Argueso, M., Arenal Lopez, S., Llamas Fernandez, N., Rodriguez, A., Garcia Del Valle, S., Rodriguez, M., Preiser, J. C., Welling, K. -L., Larche, J., Legall, J. -R., Timsit, J. -F., Sollet, J. -P., Sab, J. M., Hopf, H. -B., Stogbauer, R., Clouva-Molyvdas, P. -M., Donadio, P. P., Ranieri, V. M., De Bel, E. E., De Pont, A. -C., Zandstra, D. F., Linden, S., Lovstad, R. Z., Paiva, J. A., Izura Cea, J. J., Mcculloch, C., Vincent J.-L., Lefrant J.-Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S.G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J.C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K.-L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J.-R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J.-F., Winnock S., Sollet J.-P., Mallet L., Maurer P., Sab J.M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H.-B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P.-M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P.P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V.M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E.E., De Pont A.-C., Groeneveld J., Nijsten M., Sie L., Zandstra D.F., Harboe S., Linden S., Lovstad R.Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J.A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J.J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., and Williams D.
- Subjects
Male ,Original ,Epidemiology ,[SDV]Life Sciences [q-bio] ,HSJ UCI ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,MULTICENTER ,clinical outcome ,mortality rate ,Critical Care and Intensive Care Medicine ,intensive care unit ,law.invention ,0302 clinical medicine ,Severity of disease ,law ,middle aged ,Medicine and Health Sciences ,FAILURE ,030212 general & internal medicine ,Hospital Mortality ,intensive care units -- analysis -- epidemiology -- mortality ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,CODES ,comparative study ,intensive care ,Medicine(all) ,multilevel analysi ,Incidence ,adult ,Sciences bio-médicales et agricoles ,Intensive care unit ,3. Good health ,Europe ,sepsa ,Intensive Care Units ,female ,Cohort ,enote intenzivne terapije -- analiza -- epidemiologija -- umrljivost ,Human ,Adult ,medicine.medical_specialty ,severity of disease ,Critical Care ,Sepsi ,Intensive Care Unit ,UNITED-STATES ,610 Medicine & health ,INTENSIVE-CARE ,European ,Article ,Sepsis ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,length of stay ,male ,Humans ,Length of Stay ,Anesthesiology ,Intensive care ,SCORE ,medicine ,udc:614.2 ,human ,outcome assessment ,Septic shock ,business.industry ,SEPTIC SHOCK ,030208 emergency & critical care medicine ,medicine.disease ,TRENDS ,major clinical study ,SEVERE SEPSIS ,comorbidity assessment ,Emergency medicine ,Observational study ,CLAIMS ,business ,resnost bolezni - Abstract
Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis., 0, info:eu-repo/semantics/published
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- 2018
19. Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
- Author
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Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Vincent J. -L., Lefrant J. -Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S. G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J. C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K. -L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J. -R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J. -F., Winnock S., Sollet J. -P., Mallet L., Maurer P., Sab J. M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H. -B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P. -M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P. P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V. M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E. E., De Pont A. -C., Groeneveld J., Nijsten M., Sie L., Zandstra D. F., Harboe S., Linden S., Lovstad R. Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J. A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J. J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., Williams D., Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Vincent J. -L., Lefrant J. -Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S. G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J. C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K. -L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J. -R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J. -F., Winnock S., Sollet J. -P., Mallet L., Maurer P., Sab J. M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H. -B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P. -M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P. P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V. M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E. E., De Pont A. -C., Groeneveld J., Nijsten M., Sie L., Zandstra D. F., Harboe S., Linden S., Lovstad R. Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J. A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J. J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., and Williams D.
- Abstract
Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.
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- 2018
20. Genetic basis of rheumatoid arthritis
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Orozco, G., Rueda, B., and Martin, J.
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- 2006
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21. Trasplante de páncreas: resultados del grupo Málaga
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Navarro-Piñero, Alfonso, Jesús Castro-Santiago, M., Manuel Aranda-Narváez, José, Cabello-Díaz, Mercedes, Sola-Moyano, Eugenia, López Rueda, B., Antonio Pérez-Daga, José, Pablo Ramírez-Plaza, César, Burgos-Rodríguez, Dolores, González-Molina, Miguel, and de la Fuente-Perucho, Agustín
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- 2006
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22. A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators
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Broen, J. C. A., Bossini-Castillo, L., van Bon, L., Vonk, M. C., Knaapen, H., Beretta, L., Rueda, B., Hesselstrand, R., Herrick, A., Worthington, J., Hunzelman, N., Denton, C. P., Fonseca, C., Riemekasten, G., Kiener, H. P., Scorza, R., Simeón, C. P., Ortego-Centeno, N., Gonzalez-Gay, M. A., Airò, P., Coenen, M. J. H., Martín, J., and Radstake, T. R. D. J.
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- 2012
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23. Polymorphisms in the interleukin 4, interleukin 13 and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression
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Broen, J C A, Dieude, P, Vonk, M C, Beretta, L, Rueda, B, Herrick, A, Worthington, J, Hunzelmann, N, Riemekasten, G, Kiener, H, Scorza, R, Simeon, C P, Fonollosa, V, Carreira, P, Ortego-Centeno, N, Gonzalez-Gay, M A, Airoʼ, P, Coenen, M J H, Aliprantis, A, Martin, J, Allanore, Y, and Radstake, T R D J
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- 2011
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24. Variants of PBEF predispose to systemic sclerosis and pulmonary arterial hypertension development
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Broen, J C A, Gourh, P, Vonk, M C, Beretta, L, Niederer, F, Rueda, B, Geurts-van Bon, L, Brouwer, C, Hesselstrand, R, Herrick, A, Worthington, J, Hunzelman, N, Fonseca, Denton C, Riemekasten, G, Kiener, H, Scorza, R, Simeon, C P, Fonollosa, V, Carreira, P, Ortego-Centeno, N, Gonzalez-Gay, M A, Airoʼ, P, Coenen, M J H, Mayes, M, Kyburz, D, Arnett, F C, Martin, J, and Radstake, T R D J
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- 2011
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25. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis
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Diaz-Gallo, LM, Gourh, P, Broen, J, Simeon, C, Fonollosa, V, Ortego-Centeno, N, Agarwal, S, Vonk, MC, Coenen, M, Riemekasten, G, Hunzelmann, N, Hesselstrand, R, Tan, FK, Reveille, JD, Assassi, S, García-Hernandez, FJ, Carreira, P, Camps, MT, Fernandez-Nebro, A, de la Peña, P Garcia, Nearney, T, Hilda, D, González-Gay, MA, Airo, P, Beretta, L, Scorza, R, Herrick, A, Worthington, J, Pros, A, Gómez-Gracia, I, Trapiella, L, Espinosa, G, Castellvi, I, Witte, T, de Keyser, F, Vanthuyne, M, Mayes, MD, Radstake, TRDJ, Arnett, FC, Martin, J, and Rueda, B
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- 2011
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26. Nutrient status of cattle grazing systems in the western brazilian amazon
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Rueda, B. L., primary, McRoberts, K. C., additional, Blake, R. W., additional, Nicholson, C. F., additional, Valentim, J. F., additional, and Fernandes, E. C. M., additional
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- 2020
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27. BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians
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Rueda, B, Gourh, P, Broen, J, Agarwal, S K, Simeon, C, Ortego-Centeno, N, Vonk, M C, Coenen, M, Riemekasten, G, Hunzelmann, N, Hesselstrand, R, Tan, F K, Reveille, J D, Assassi, S, Garcia-Hernandez, F J, Carreira, P, Camps, M, Fernandez-Nebro, A, de la Peña, P Garcia, Nearney, T, Hilda, D, Gónzalez-Gay, M A, Airo, P, Beretta, L, Scorza, R, Radstake, T R, Mayes, M D, Arnett, F C, and Martin, J
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- 2010
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28. The FAS −670A>G polymorphism influences susceptibility to systemic sclerosis phenotypes
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Broen, J., Gourh, P., Rueda, B., Coenen, M., Mayes, M., Martin, J., Arnett, F. C., and Radstake, T. R. D. J.
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- 2009
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29. Preemptive therapy is not adequate for prevention of cytomegalovirus disease in pancreas–kidney transplant recipients
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López-Medrano, F., Rueda, B., Lizasoain, M., Juan, San R., Folgueira, D., Andrés, A., Morales, J. M., Jiménez, C., Meneu, J. C., and Aguado, J. M.
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- 2009
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30. A large multicentre analysis of CTGF −945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype
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Rueda, B, Simeon, C, Hesselstrand, R, Herrick, A, Worthington, J, Ortego-Centeno, N, Riemekasten, G, Fonollosa, V, Vonk, M C, van den Hoogen, F H J, Sanchez-Román, J, Aguirre-Zamorano, M A, García-Portales, R, Pros, A, Camps, M T, Gonzalez-Gay, M A, Gonzalez-Escribano, M F, Coenen, M J, Lambert, N, Nelson, J L, Radstake, T R D J, and Martin, J
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- 2009
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31. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population
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Lamsyah, H., Rueda, B., Baassi, L., Elaouad, R., Bottini, N., Sadki, K., and Martin, J.
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- 2009
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32. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype
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Rueda, B, Broen, J, Simeon, C, Hesselstrand, R, Diaz, B, Suárez, H, Ortego-Centeno, N, Riemekasten, G, Fonollosa, V, Vonk, MC, van den Hoogen, FHJ, Sanchez-Román, J, Aguirre-Zamorano, MA, García-Portales, R, Pros, A, Camps, MT, Gonzalez-Gay, MA, Coenen, MJH, Airo, P, Beretta, L, Scorza, R, van Laar, J, Gonzalez-Escribano, MF, Nelson, JL, Radstake, TRDJ, and Martin, J
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- 2009
33. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype
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Rueda, B, Broen, J, Torres, O, Simeon, C, Ortego-Centeno, N, Schrijvenaars, M M V A P, Vonk, M C, Fonollosa, V, van den Hoogen, F H J, Coenen, M J H, Sanchez-Román, J, Aguirre-Zamorano, M A, García-Portales, R, Pros, A, Camps, M T, Gonzalez-Gay, M A, Martin, J, and Radstake, T R D J
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- 2009
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34. Involvement of macrophage migration inhibitory factor gene in celiac disease susceptibility
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Núñez, C, Rueda, B, Martínez, A, López-Nevot, M A, Fernández-Arquero, M, de la Concha, E G, Martín, J, and Urcelay, E
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- 2007
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35. The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
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Rueda, B, Orozco, G, Raya, E, Fernandez-Sueiro, J L, Mulero, J, Blanco, F J, Vilches, C, González-Gay, M A, and Martin, J
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- 2008
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36. Investigation of CD69 as a new candidate gene for rheumatoid arthritis
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Rueda, B., Fernandez-Gutierrez, B., Balsa, A., Pacual-Salcedo, D., Lamas, J. R., Raya, E., Gonzalez-Gay, M. A., and Martin, J.
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- 2008
37. Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases
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Acosta-Herrera, Marialbert, Kerick, Martin, González-Serna, David, Wijmenga, Cisca, Franke, Andre, Gregersen, Peter K., Padyukov, Leonid, Worthington, J., Vyse, T. J., Alarcón-Riquelme, M. E., Mayes, M. D., Martín, J., Miller, Frederick W., Chen, Wei, O'Hanlon, Terrance P., Cooper, Robert G., Vencovsky, Jiri, Rider, Lisa G, Danko, Katalin, Wedderburn, Lucy R., Lundberg, Ingrid E., Pachman, Lauren M., Reed, Ann M., Ytterberg, Steven R, Selva-O'Callaghan, Alber, Radstake, Timothy R., Isenberg, David A, Chinoy, Hector, Ollier, William E. R, Scheet, Paul, Peng, Bo, Lee, Annette, Lamb, Janine A., Amos, Christopher I., Denton, Christopher, Hilton-Jones, David, Plotz, Paul H., Varsani, Hemlata, Radstake, Timothy R. D. J., Gorlova, Olga, Rueda, B., Martín, J. E., Alizadeh, B. Z., Palomino-Morales, Rogelio, Coenen, Marieke J. H., Vonk, Madelon C., Voskuyl, Alexandre E., Scheurwegh, Annemie J., Broen, Jasper C., van Riel, Piet L. C. M., van 't Slot, Rubén, Italiaander, Annet, Ophoff, Roel A., Riemekasten, Gabriela, Hunzelmann, Nicolas, Simeon, Carmen P., Ortego-Centeno, N., González-Gay, M. A., González-Escribano, María Francisca, Airó, Paolo, van Laar, Jaap, Herrick, Ariane L., Hesselstrand, Roger, Smith, Vanessa, de Keyser, Filip, Houssiau, Fredric, Chee, Meng May, Madhok, Rajan, Shiels, Paul, Westhovens, Rene, Kreuter, A., Kiener, Hans, de Baere, Elfride, Witte, Torsten, Klareskog, Lars, Beretta, Lorenzo, Scorza, Rafaella, Lie, Benedicte A., Hoffman-Vold, A. M., Carreira, P., Varga, John, Hinchcliff, Monique, Lee, Annette T., Ying, Jun, Han, Younghun, Weng, Shih-Feng, Wigley, Fredrick M., Hummers, L. K., Nelson, J. Lee, Agarwal, Sandeep K., Assassi, S., Gourh, Pravitt, Tan, Filemon K., Koeleman, B. P., Arnett, Frank C., Myositis Genetics Consortium, Scleroderma Genetics Consortium., Innovative Medicines Initiative, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, National Institute of Environmental Health Sciences (US), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Polymer Chemistry and Bioengineering, Life Course Epidemiology (LCE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Myositis Genetics Consortium, and Scleroderma Genetics Consortium
- Subjects
0301 basic medicine ,Male ,Lydia Becker Institute ,PATHOGENESIS ,PROTEIN ,Arthritis ,VARIANTS ,medicine.disease_cause ,Myositis Genetics Consortium ,Autoimmunity ,Scleroderma ,Arthritis, Rheumatoid ,0302 clinical medicine ,Scleroderma Genetics Consortium ,Rheumatoid ,MULTIPLE ,Lupus Erythematosus, Systemic ,Immunology and Allergy ,Medicine ,2.1 Biological and endogenous factors ,Aetiology ,Genetics ,autoimmunity ,Family aggregation ,Lim Kinases ,ASSOCIATION ,Single Nucleotide ,Public Health and Health Services ,Female ,ARTHRITIS ,Life Sciences & Biomedicine ,alpha Karyopherins ,Adult ,medicine.medical_specialty ,GENETICS ,gene polymorphism ,Quantitative Trait Loci ,Clinical Sciences ,Immunology ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Autoimmune Disease ,General Biochemistry, Genetics and Molecular Biology ,White People ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,Immune system ,Rheumatology ,Internal medicine ,Rheumatic Diseases ,ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation ,Humans ,Genetic Predisposition to Disease ,autoimmune diseases ,Polymorphism ,SCLEROSIS ,COMMON ,030203 arthritis & rheumatology ,Science & Technology ,Scleroderma, Systemic ,COMPLEX ,Myositis ,Lupus Erythematosus ,business.industry ,Inflammatory and immune system ,Systemic ,Human Genome ,Membrane Proteins ,medicine.disease ,Arthritis & Rheumatology ,Repressor Proteins ,030104 developmental biology ,Expression quantitative trait loci ,Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] ,Human medicine ,Gene polymorphism ,business ,Genome-Wide Association Study - Abstract
ObjectiveImmune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions with overlapping clinical symptoms and elevated familial aggregation, which suggests the existence of a shared genetic component. In order to identify this genetic background in a systematic fashion, we performed the first cross-disease genome-wide meta-analysis in systemic seropositive rheumatic diseases, namely, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and idiopathic inflammatory myopathies.MethodsWe meta-analysed ~6.5 million single nucleotide polymorphisms in 11 678 cases and 19 704 non-affected controls of European descent populations. The functional roles of the associated variants were interrogated using publicly available databases.ResultsOur analysis revealed five shared genome-wide significant independent loci that had not been previously associated with these diseases: NAB1, KPNA4-ARL14, DGQK, LIMK1 and PRR12. All of these loci are related with immune processes such as interferon and epidermal growth factor signalling, response to methotrexate, cytoskeleton dynamics and coagulation cascade. Remarkably, several of the associated loci are known key players in autoimmunity, which supports the validity of our results. All the associated variants showed significant functional enrichment in DNase hypersensitivity sites, chromatin states and histone marks in relevant immune cells, including shared expression quantitative trait loci. Additionally, our results were significantly enriched in drugs that are being tested for the treatment of the diseases under study.ConclusionsWe have identified shared new risk loci with functional value across diseases and pinpoint new potential candidate loci that could be further investigated. Our results highlight the potential of drug repositioning among related systemic seropositive rheumatic IMIDs.
- Published
- 2019
38. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
- Author
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Kotfis, Katarzyna Wittebole, Xavier Jaschinski, Ulrich and Sole-Violan, Jordi Kashyap, Rahul Leone, Marc Nanchal, Rahul and Fontes, Luis E. Sakr, Yasser Vincent, Jean-Louis Tomas, E. Bibonge, E. Amisi Charra, B. Faroudy, M. Doedens, L. and Farina, Z. Adler, D. Balkema, C. Kok, A. Alaya, S. and Gharsallah, H. Muzha, D. Temelkov, A. Georgiev, G. and Simeonov, G. Tsaryanski, G. Georgiev, S. Seliman, A. and Vrankovic, S. Vucicevic, Z. Gornik, I Barsic, B. and Husedzinovic, I Pavlik, P. Manak, J. Kieslichova, E. and Turek, R. Fischer, M. Valkova, R. Dadak, L. Dostal, P. and Malaska, J. Hajek, R. Zidkova, A. Lavicka, P. and Starkopf, J. Kheladze, Z. Chkhaidze, M. Kaloiani, V and Medve, L. Sarkany, A. Kremer, I Marjanek, Z. Tamasi, P. and Krupnova, I Vanags, I Liguts, V Pilvinis, V and Vosylius, S. Kekstas, G. Balciunas, M. Kolbusz, A. and Kubler, A. Mielczarek, B. Mikaszewska-Sokolewicz, M. Kotfis, K. Tamowicz, B. Sulkowski, W. Smuszkiewicz, P. Pihowicz, A. Trejnowska, E. Hagau, N. Filipescu, D. Droc, G. and Lupu, M. Nica, A. Stoica, R. Tomescu, D. Constantinescu, D. Zbaganu, G. Valcoreanu Slavcovici, A. Bagin, V and Belsky, D. Palyutin, S. Shlyapnikov, S. Bikkulova, D. and Gritsan, A. Natalia, G. Makarenko, E. Kokhno, V Tolkach, A. Kokarev, E. Belotserkovskiy, B. Zolotukhin, K. and Kulabukhov, V Soskic, L. Palibrk, I Jankovic, R. and Jovanovic, B. Pandurovic, M. Bumbasirevic, V Uljarevic, B. and Surbatovic, M. Ladjevic, N. Slobodianiuk, G. Sobona, V and Cikova, A. Gebhardtova, A. Jun, C. Yunbo, S. Dong, U. Feng, S. Duan, M. Xu, Y. Xue, X. Gao, T. and Xing, X. Zhao, X. Li, C. Gengxihua, G. Tan, H. Xu, J. Jiang, L. Tiehe, Q. Bingyu, Q. Shi, Q. Lv, Z. and Zhang, L. Jingtao, L. Zhen, Z. Wang, Z. Wang, T. and Yuhong, L. Zhai, Q. Chen, Y. Wang, C. Jiang, W. and Ruilan, W. Chen, Y. Xiaobo, H. Ge, H. Yan, T. Yuhui, C. Zhang, J. Jian-Hong, F. Zhu, H. Huo, F. Wang, Y. and Li, C. Zhuang, M. Ma, Z. Sun, J. Liuqingyue, L. and Yang, M. Meng, J. Ma, S. Kang, Y. Yu, L. Peng, Q. and Wei, Y. Zhang, W. Sun, R. Yeung, A. Wan, W. Sin, K. Lee, K. Wijanti, M. Widodo, U. Samsirun, H. and Sugiman, T. Wisudarti, C. Maskoen, T. Hata, N. Kobe, Y. and Nishida, O. Miyazaki, D. Nunomiya, S. Uchino, S. and Kitamura, N. Yamashita, K. Hashimoto, S. Fukushima, H. and Adib, N. Nik Tai, L. Tony, B. Bigornia, R. Palo, J. and Chatterjee, S. Tan, B. Kong, A. Goh, S. Lee, C. and Pothirat, C. Khwannimit, B. Theerawit, P. Pornsuriyasak, P. and Piriyapatsom, A. Mukhtar, A. Dsicu Hamdy, A. Nabil and Hosny, H. Ashraf, A. Mokhtari, M. Nowruzinia, S. Lotfi, A. Zand, F. Nikandish, R. Moghaddam, O. Moradi Cohen, J. and Sold, O. Sfeir, T. Hasan, A. Abugaber, D. Ahmad, H. and Tantawy, T. Baharoom, S. Algethamy, H. Amr, A. and Almekhlafi, G. Coskun, R. Sungur, M. Cosar, A. and Gucyetmez, B. Demirkiran, O. Senturk, E. Ulusoy, H. and Atalan, H. Serin, S. Kati, I Alnassrawi, Z. Almemari, A. and Krishnareddy, K. Kashef, S. Alsabbah, A. Poirier, G. and Marshall, J. Herridge, M. Herridge, M. Fernandez-Medero, R. and Fulda, G. Banschbach, S. Quintero, J. Schroeder, E. and Sicoutris, C. Gueret, R. Kashyap, R. Bauer, P. Nanchal, R. Wunderink, R. Jimenez, E. Ryan, A. Prince, D. and Edington, J. Van Haren, F. Bersten, A. Hawkins, D. J. and Kilminster, M. Sturgess, D. Ziegenfuss, M. O'Connor, S. and Lipman, J. Campbell, L. Mcallister, R. Roberts, B. and Williams, P. Parke, R. Seigne, P. Freebairn, R. Nistor, D. Oxley, C. Young, P. Valentini, R. Wainsztein, N. and Comignani, P. Casaretto, M. Sutton, G. Villegas, P. and Galletti, C. Neira, J. Rovira, D. Hidalgo, J. Sandi, F. and Caser, E. Thompson, M. D'agostino Dias, M. Fontes, L. and Lunardi, M. Youssef, N. Lobo, S. Silva, R. Sales Jr, J. Madeira Campos Melo, L. Oliveira, M. Fonte, M. Grion, C. Feijo, C. Rezende, V Assuncao, M. Neves, A. and Gusman, P. Dalcomune, D. Teixeira, C. Kaefer, K. Maia, I and Souza Dantas, V Costa Filho, R. Amorim, F. Assef, M. and Schiavetto, P. Houly, J. Bianchi, F. Dias, F. Avila, C. and Gomez, J. Rego, L. Castro, P. Passos, J. Mendes, C. and Grion, C. Colozza Mecatti, G. Ferrreira, M. Irineu, V and Guerreiro, M. Ugarte, S. Tomicic, V Godoy, C. and Samaniego, W. Escamilla, I Castro Castro, L. Libreros Duque, G. Diaz-Guio, D. Benitez, F. Guerra Urrego, A. Buitrago, R. Ortiz, G. Villalba Gaviria, M. Salas, D. and Ramirez-Arce, J. Salgado, E. Morocho, D. Vergara, J. and Chung Sang, M. Orellana-Jimenez, C. Garrido, L. Diaz, O. and Resiere, D. Osorio, C. De La Vega, A. Carrillo, R. and Sanchez, V Villagomez, A. Martinez Zubieta, R. Sandia, M. and Zalatiel, M. Poblano, M. Rodriguez Gonzalez, D. and Arrazola, F. Juan Francisco, L. Liamendys-Silva, S. A. and Hernandez, M. Rodriguez Cadena, D. Lopez Islas, I. and Ballesteros Zarzavilla, C. Matos, A. Oyanguren, I Cerna, J. and Quispe Sierra, R. Jimenez, R. Castillo, L. Ocal, R. and Sencan, A. Gianoni, S. Mareque Deicas, A. Hurtado, J. and Burghi, G. Martinelli, A. Von der Osten, I Du Maine, C. and Bhattacharyya, M. Bandyopadhyay, S. Yanamala, S. Gopal, P. and Sahu, S. Ibrahim, M. Rathod, D. Mukundan, N. Dewan, A. Amin, P. Samavedam, S. Shah, B. Gurupal, D. and Lahkar, B. Mandal, A. Sircar, M. Ghosh, S. and Balasubramani, V Kapadia, F. Vadi, S. Nair, K. Tripathy, S. Nandakumar, S. Sharma, J. Kar, A. Jha, S. Gurav, K. Zirpe Patel, M. Bhaysar, A. Samaddar, D. Kulkarni, A. and Hashmi, M. Ali, W. Nadeem, S. Indraratna, K. and Margarit, A. Urbanek, P. Schlieber, J. Reisinger, J. and Auer, U. Hartjes, A. Lerche, A. Janous, T. Kink, E. and Krahulec, W. Smolle, K. Van der Schueren, M. Thibo, P. and Vanhoof, M. Ahmet, I Gadisseux, P. Dufaye, P. Jacobs, O. and Fraipont, V Biston, P. Dive, A. Bouckaert, Y. and Gilbert, E. Gressens, B. Pinck, E. Collin, V Vincent, J. L. De Waele, J. Rimachi, R. Gusu, D. De Decker, K. and Mandianga, K. Heytens, L. Wittebole, X. Spapen, H. and Olivier, V Vandenheede, W. Rogiers, P. Kolodzeike, P. and Kruse, M. Andersen, T. Harjola, V Saarinen, K. Leone, M. and Durocher, A. Moulront, S. Lepape, A. Losser, M. and Cabaret, P. Kalaitzis, E. Zogheib, E. Charve, P. and Francois, B. Lefrant, J. Y. Beilouny, B. Forceville, X. and Misset, B. Jacobs, F. Floccard, B. Payen, D. Wynckel, A. and Castelain, V Faure, A. Lavagne, P. Thierry, I and Moussa, M. Vieillard-Baron, A. Durand, M. Gainnier, M. and Ichai, C. Arens, S. Hoffmann, C. Kaffarnik, M. and Scharnofske, C. Voigt, I Peckelsen, C. Weber, M. Gille, J. Lange, A. Schoser, G. Sablotzki, A. Jaschinski, U. and Bluethgen, A. Vogel, F. Tscheu, A. Fuchs, T. and Wattenberg, M. Helmes, T. Scieszka, S. Heintz, M. Sakka, S. Kohler, J. Fiedler, F. Danz, M. Sakr, Y. Riessen, R. Kerz, T. Kersten, A. Tacke, F. Marx, G. Volkert, T. Schmutz, A. Nierhaus, A. Kluge, S. Abel, P. and Janosi, R. Utzolino, S. Bracht, H. Toussaint, S. and Peftoulidou, M. Giannakou Myrianthefs, P. Armaganidis, A. and Routsi, C. Xini, A. Mouloudi, E. Kokoris, I and Kyriazopoulos, G. Vlachos, S. Lavrentieva, A. Partala, P. and Nakos, G. Moller, A. Stefansson, S. Barry, J. and O'Leary, R. Motherway, C. Faheem, M. Dunne, E. Donnelly, M. Konrad, T. Bonora, E. Achilli, C. Rossi, S. and Castiglione, G. Penis, A. Albanese, D. Stocchetti, N. and Citerio, G. Mozzoni, L. Sisillo, E. De Negri, P. and Savioli, M. Vecchiarelli, P. Puflea, F. Stankovic, V and Minoja, G. Montibeller, S. Calligaro, P. Sorrentino, R. and Feri, M. Zambon, M. Colombaroli, E. Giarratano, A. and Pellis, T. Capra, C. Antonelli, M. Gullo, A. Chelazzi, C. De Capraris, A. Patroniti, N. Girardis, M. Franchi, F. Berlot, G. Buttigieg, M. Ponssen, H. Cate, J. Ten and Bormans, L. Husada, S. Buise, M. Van Der Hoven, B. and Reidinga, A. Kuiper, M. Pickkers, P. Kluge, G. Den Boer, S. Kesecioglu, J. Van Leeuwen, H. Flaatten, H. Mo, S. and Branco, V Rua, F. Lafuente, E. Sousa, M. Catorze, N. and Barros, M. Pereira, L. De Oliveira, A. Vintern Gomes, J. and Gaspar, I Pereira, M. Cymbron, M. Dias, A. Almeida, E. Beirao, S. Serra, I Ribeiro, R. Povoa, P. Faria, F. Costa-E-Silva, Z. Nobrega, A. Fernandes, F. Gabriel, J. Voga, G. Rupnik, E. Kosec, L. Povsic, M. Kerin and Osojnik, I Tomic, V Sinkovic, A. Gonzalez, J. Zavala, E. and Perez Valenzuela, A. Marina, L. Vidal-Cortes, P. Posada, I Ignacio Martin-Loeches, A. Munoz Guillen, N. Palomar, M. and Sole-Violan, U. Torres, A. Gonzalez Gallego, M. Aguilar, G. Montoiro Allue, R. Argueso, M. Parejo, M. Palomo Navarro, M. Jose, A. Nin, N. Alvarez Lerma, F. Martinez, O. Tenza Lozano, E. Arenal Lopez, S. Perez Granda, M. and Moreno, S. Llubia, C. De la Fuente Martos, C. and Gonzalez-Arenas, P. Llamas Fernandez, N. Gil Rueda, B. and Estruch Pons, I Cruza, N. Maroto, F. Estella, A. Ferrer, A. Iglesias Fraile, L. Quindos, B. Quintano, A. Tebar, M. Cardinal, I Reyes, A. Rodriguez, A. Abella, A. and Garcia Del Valle, S. Yus, S. Maseda, E. Berezo, U. and Tejero Pedregosa, A. Laplaza, C. Ferrer, R. Rico-Feijoo, U. and Rodriguez, M. Monedero, P. Eriksson, K. Lind, D. and Chabanel, D. Zender, H. Heer, K. Frankenberger, B. and Jakob, S. Mathew, S. Downes, R. Groba, C. Barrera and Johnston, A. Meacher, R. Keays, R. Haji-Michael, P. and Tyler, C. Ferguson, A. Jones, S. Tyl, D. Ball, A. and Vogel, U. Booth, M. Downie, P. Watters, M. Brett, S. and Garfield, M. Everett, L. Heenen, S. Dhir, S. Beardow, Z. and Mostert, M. Brosnan, S. Pinto, N. Harris, S. and Summors, A. Andrew, N. Rose, A. Appelboam, R. Davies, O. and Vickers, E. Agarwal, B. Szakmany, T. Wimbush, S. and Welters, I Pearse, R. Hollands, R. Kirk-Bayley, U. and Fletcher, N. Bray, B. Brealey, D. ICON Investigators
- Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved.
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- 2019
39. Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus
- Author
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Sánchez, E., Rueda, B., Callejas, J. L., Sabio, J. M., Ortego-Centeno, N., Jimenez-Alonso, J., López-Nevot, M. A., and Martín, J.
- Published
- 2007
40. Contribution of MHC class I region to genetic susceptibility for giant cell arteritis
- Author
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Gonzalez-Gay, M. A., Rueda, B., Vilchez, J. R., Lopez-Nevot, M. A., Robledo, G., Ruiz, M. P., Fernández, O., Garcia-Porrua, C., Gonzalez-Escribano, M. F., and Martín, J.
- Published
- 2007
41. Comparison of mRNA levels for the PGF2α receptor (FP) during luteolysis and early pregnancy in the ovine corpus luteum
- Author
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Rueda, B. R., Botros, I. W., Pierce, K. L., Regan, J. W., and Hoyer, P. B.
- Published
- 1995
- Full Text
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42. A functional variant of IFNγ gene is associated with coeliac disease
- Author
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Rueda, B, Martínez, A, López-Nevot, M A, Mas-Fontao, A, Paco, L, Ortega, E, Fernández-Arquero, M, Urcelay, E, Concha, E Gomez de la, and Martín, J
- Published
- 2004
- Full Text
- View/download PDF
43. Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease
- Author
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Rueda, B., Koeleman, B. P. C., López-Nevot, M. A., Ortega, E., Maldonado, J., López, M., Polanco, I., and Martín, J.
- Published
- 2005
44. Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis
- Author
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Rueda, B., González-Gay, M. Á., Mataran, L., López-Nevot, M. Á., and Martín, J.
- Published
- 2005
45. Leptin Serves as an Upstream Activator of an Obligatory Signaling Cascade in the Embryo-Implantation Process
- Author
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Ramos, M P., Rueda, B R., Leavis, P C., and Gonzalez, R R.
- Published
- 2005
46. Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases
- Author
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Innovative Medicines Initiative, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, National Institute of Environmental Health Sciences (US), Acosta-Herrera, Marialbert, Kerick, Martin, González-Serna, David, Wijmenga, Cisca, Franke, Andre, Gregersen, Peter K., Padyukov, Leonid, Worthington, J., Vyse, T. J., Alarcón-Riquelme, M. E., Mayes, Maureen D., Martín, J., Miller, Frederick W., Chen, Wei, O'Hanlon, Terrance P., Cooper, Robert G., Vencovsky, Jiri, Rider, Lisa G, Danko, Katalin, Wedderburn, Lucy R., Lundberg, Ingrid E., Pachman, Lauren M., Reed, Ann M., Ytterberg, Steven R, Selva-O'Callaghan, Alber, Radstake, Timothy R., Isenberg, David A, Chinoy, Hector, Ollier, William E. R, Scheet, Paul, Peng, Bo, Lee, Annette T., Lamb, Janine A., Amos, Christopher I., Denton, Christopher, Hilton-Jones, David, Plotz, Paul H., Varsani, Hemlata, Radstake, Timothy R. D. J., Gorlova, Olga, Rueda, B., Martín, J. E., Alizadeh, B. Z., Palomino-Morales, Rogelio, Coenen, Marieke J. H., Vonk, Madelon C., Voskuyl, Alexandre E., Scheurwegh, Annemie J., Broen, Jasper C., van Riel, Piet L. C. M., van 't Slot, Rubén, Italiaander, Annet, Ophoff, Roel A., Riemekasten, Gabriela, Hunzelmann, Nicolas, Simeón, Carmen P., Ortego-Centeno, N., González-Gay, M. A., González-Escribano, María Francisca, Airó, Paolo, van Laar, Jaap, Herrick, Ariane L., Hesselstrand, Roger, Smith, Vanessa, de Keyser, Filip, Houssiau, Fredric, Chee, Meng May, Madhok, Rajan, Shiels, Paul, Westhovens, Rene, Kreuter, A., Kiener, Hans, de Baere, Elfride, Witte, Torsten, Klareskog, Lars, Beretta, Lorenzo, Scorza, Rafaella, Lie, Benedicte A., Hoffman-Vold, A. M., Carreira, P., Varga, John, Hinchcliff, Monique, Ying, Jun, Han, Younghun, Weng, Shih-Feng, Wigley, Fredrick M., Hummers, L. K., Nelson, J. Lee, Agarwal, Sandeep K., Assassi, S., Gourh, Pravitt, Tan, Filemon K., Koeleman, B. P., Arnett, Frank C., Myositis Genetics Consortium, Scleroderma Genetics Consortium., Innovative Medicines Initiative, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, National Institute of Environmental Health Sciences (US), Acosta-Herrera, Marialbert, Kerick, Martin, González-Serna, David, Wijmenga, Cisca, Franke, Andre, Gregersen, Peter K., Padyukov, Leonid, Worthington, J., Vyse, T. J., Alarcón-Riquelme, M. E., Mayes, Maureen D., Martín, J., Miller, Frederick W., Chen, Wei, O'Hanlon, Terrance P., Cooper, Robert G., Vencovsky, Jiri, Rider, Lisa G, Danko, Katalin, Wedderburn, Lucy R., Lundberg, Ingrid E., Pachman, Lauren M., Reed, Ann M., Ytterberg, Steven R, Selva-O'Callaghan, Alber, Radstake, Timothy R., Isenberg, David A, Chinoy, Hector, Ollier, William E. R, Scheet, Paul, Peng, Bo, Lee, Annette T., Lamb, Janine A., Amos, Christopher I., Denton, Christopher, Hilton-Jones, David, Plotz, Paul H., Varsani, Hemlata, Radstake, Timothy R. D. J., Gorlova, Olga, Rueda, B., Martín, J. E., Alizadeh, B. Z., Palomino-Morales, Rogelio, Coenen, Marieke J. H., Vonk, Madelon C., Voskuyl, Alexandre E., Scheurwegh, Annemie J., Broen, Jasper C., van Riel, Piet L. C. M., van 't Slot, Rubén, Italiaander, Annet, Ophoff, Roel A., Riemekasten, Gabriela, Hunzelmann, Nicolas, Simeón, Carmen P., Ortego-Centeno, N., González-Gay, M. A., González-Escribano, María Francisca, Airó, Paolo, van Laar, Jaap, Herrick, Ariane L., Hesselstrand, Roger, Smith, Vanessa, de Keyser, Filip, Houssiau, Fredric, Chee, Meng May, Madhok, Rajan, Shiels, Paul, Westhovens, Rene, Kreuter, A., Kiener, Hans, de Baere, Elfride, Witte, Torsten, Klareskog, Lars, Beretta, Lorenzo, Scorza, Rafaella, Lie, Benedicte A., Hoffman-Vold, A. M., Carreira, P., Varga, John, Hinchcliff, Monique, Ying, Jun, Han, Younghun, Weng, Shih-Feng, Wigley, Fredrick M., Hummers, L. K., Nelson, J. Lee, Agarwal, Sandeep K., Assassi, S., Gourh, Pravitt, Tan, Filemon K., Koeleman, B. P., Arnett, Frank C., Myositis Genetics Consortium, and Scleroderma Genetics Consortium.
- Published
- 2019
47. Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling
- Author
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Gonzalez, R R., Rueda, B R., Ramos, M P., Littell, R D., Glasser, S, and Leavis, P C.
- Published
- 2004
48. CA microsatellite polymorphism of the nuclear factor kappa B1 gene in celiac disease
- Author
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Rueda, B., López-Nevot, M. A., Ruiz, M. P., Ortega, E., Maldonado, J., López, M., and Martin, J.
- Published
- 2004
49. A new allele within the transmembrane region of the human MICA gene with seven GCT repeats
- Author
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Rueda, B., Pascual, M., López-Nevot, M. A., González, E., and Martín, J.
- Published
- 2002
50. Evaluation of various pesticides-degrading pure bacterial cultures isolated from pesticide-contaminated soils in Ecuador
- Author
-
Pérez Mónica, Bangeppagari Manjunatha, Naga Raju Maddela, Johana J. Zúñiga, Rueda O. Darwin, Rueda B. Bryan, RÃos Diego, and Sikandar I. Mulla
- Subjects
0106 biological sciences ,biology ,business.industry ,010501 environmental sciences ,Pesticide ,Bacterial growth ,Microbial consortium ,biology.organism_classification ,16S ribosomal RNA ,01 natural sciences ,Applied Microbiology and Biotechnology ,Pseudomonas putida ,Biotechnology ,Bioremediation ,Bioremediation, spectrophotometer, bioreactors, pesticides, consortium ,010608 biotechnology ,Genetics ,Bioreactor ,Food science ,business ,Agronomy and Crop Science ,Molecular Biology ,Bacteria ,0105 earth and related environmental sciences - Abstract
Due to the intensive use of pesticides within the greenhouse-rose production, remediation of polluted soils has become a hot topic for researchers in recent decades. Several bacterial strains having the ability to utilize various pesticides as a sole source of carbon and energy were isolated from pesticide-contaminated soils of Urcuqui, Ecuador. According to phenotypical, physiological, and biochemical characterizations, and 16S rRNA gene sequence analysis, the isolated pure bacterial cultures were identified as Pseudomonas putida sp. strain B1, Acinetobacter sp. strain B2 and Arthrobacter sp. strain B3. The bacterial isolates were used individually and mixed cultures were used in the laboratory and field experimentations for the degradation of various pesticides like Ridomil MZ 68 MG, Fitoraz WP 76, Cleaner, Decis 2.5 CE, Score 250 EC, Zero 5 EC, Bravo 720 SC, Meltatox, Mirage 45 CE and Teldor Combi at 50 mgL-1. The bacterial growth was monitored on both liquid culture medium (in laboratory) and field experiments by spectrophotometer method, Neubauer camera and colony-forming units. In addition, the degradation of individual pesticides (50 mgL-1) was determined by ultra-high performance liquid chromatography-tandem mass-spectrometry and UV-VIS spectrophotometer. The results showed that the highest growth rate of microbial consortium was observed during degradation of various pesticides than individual pure bacteria for both experiments. In addition, most pesticides were completely degraded by microbial consortium after 60 days. Key words: Bioremediation, spectrophotometer, bioreactors, pesticides, consortium.
- Published
- 2016
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