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3. Natural History of Myocardial αvβ3Integrin Expression After Acute Myocardial Infarction: Correlation with Changes in Myocardial Blood Flow

Author

Dietz, Matthieu, primary, Kamani, Christel H., additional, Bousige, Colin, additional, Dunet, Vincent, additional, Delage, Judith, additional, Rubimbura, Vladimir, additional, Nicod Lalonde, Marie, additional, Treglia, Giorgio, additional, Schaefer, Niklaus, additional, Nammas, Wail, additional, Saraste, Antti, additional, Knuuti, Juhani, additional, Mewton, Nathan, additional, and Prior, John O., additional

Published
2024
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6. Biodegradable-Polymer or Durable-Polymer Stents in Patients at High Bleeding Risk: A Randomized, Open-Label Clinical Trial

Author

Valgimigli, Marco, primary, Wlodarczak, Adrian, additional, Tölg, Ralph, additional, Merkely, Béla, additional, Kelbæk, Henning, additional, Legutko, Jacek, additional, Galli, Stefano, additional, Godin, Matthieu, additional, Toth, Gabor G., additional, Lhermusier, Thibault, additional, Honton, Benjamin, additional, Dietrich, Peter Laurenz, additional, Stammen, Francis, additional, Ferdinande, Bert, additional, Silvain, Johanne, additional, Capodanno, Davide, additional, Cayla, Guillaume, additional, Valgimigli, Marco, additional, Moccetti, Marco, additional, Toth-Gayor, Gabor G., additional, Sanguineti, Francesca, additional, Birkemeyer, Ralf, additional, Schneider, Steffen, additional, Büllesfeld, Lutz, additional, Witzenbichler, Bernhard, additional, Hochadel, Matthias, additional, Collins, Nicolas, additional, Shiekh, Imran, additional, Van Gaal, William, additional, Brandt, Mathias-Christoph, additional, Kefer, Joëlle, additional, Coussement, Patrick, additional, Olsen, Niels Thue, additional, Puymirat, Etienne, additional, Lemesle, Gilles, additional, Romain, Didier, additional, Haude, Michael, additional, Schmitz, Thomas, additional, Sherif, Mohammad, additional, Wöhrle, Jochen, additional, Arthur Yung, See Yue, additional, Yan, Bryan, additional, Vorobcsuk, András, additional, Horvath, Ivan, additional, Ferlini, Marco, additional, Nicolini, Elisa, additional, Erglis, Andrejs, additional, Kalnins, Artis, additional, Azmi, Shaiful, additional, Somi, Samer, additional, Somaratne, Jithendra, additional, Zhi Lin, Deanna Khoo, additional, de la Torre Hernandez, Jose Maria, additional, Bosco, Alfonso Torres, additional, Fores, Juan Sanchis, additional, Fournier, Stéphane, additional, Iglesias, Juan, additional, Rubimbura, Vladimir, additional, and Kehasukcharoen, Wirash, additional

Published
2023
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8. PO-05-132 ROLE OF PERIPROCEDURAL ECG AND ELECTROPHYSIOLOGICAL FINDINGS TO PREDICT HIGH DEGREE ATRIOVENTRICULAR BLOCK AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT

Author

Pagnoni, Mattia, primary, Meier, David, additional, Luca, Adrian, additional, Fournier, Stephane, additional, Aminfar, Farhang, additional, Gentil, Pascale, additional, Haddad, Christelle, additional, Maurizi, Niccolo, additional, Domenichini, Giulia, additional, Le Bloa, Mathieu, additional, Herrera-Siklody, Claudia, additional, Teres, Cheryl, additional, Cook, Stephane, additional, Goy, Jean-Jacques, additional, Togni, Mario, additional, Roguelov, Christan, additional, Girod, Gregoire, additional, Rubimbura, Vladimir, additional, Dupré, Marion, additional, Eeckhout, Eric, additional, Pruvot, Etienne, additional, Muller, Olivier, additional, and Pascale, Patrizio, additional

Published
2023
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9. The POT-PUFF sign: an angiographic mark of stent malapposition during proximal optimisation

Author

Aminfar, Farhang, primary, Rubimbura, Vladimir, additional, Maillard, Luc, additional, Noble, Stéphane, additional, Rangé, Grégoire, additional, Belle, Loic, additional, Derimay, Francois, additional, Bellemain-Appaix, Anne, additional, Al Karaky, Alexis, additional, Morelle, Jean Francois, additional, Sideris, Georgios, additional, Motreff, Pascal, additional, Muller, Olivier, additional, and Adjedj, Julien, additional

Published
2023
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10. Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT

Author

Dietz, Matthieu, primary, Kamani, Christel H., additional, Allenbach, Gilles, additional, Rubimbura, Vladimir, additional, Fournier, Stephane, additional, Dunet, Vincent, additional, Treglia, Giorgio, additional, Nicod Lalonde, Marie, additional, Schaefer, Niklaus, additional, Eeckhout, Eric, additional, Muller, Olivier, additional, and Prior, John O., additional

Published
2022
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11. Corrigendum: Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters

Author

Pagnoni, Mattia, primary, Meier, David, additional, Luca, Adrian, additional, Fournier, Stephane, additional, Aminfar, Farhang, additional, Gentil, Pascale, additional, Haddad, Christelle, additional, Domenichini, Giulia, additional, Le Bloa, Mathieu, additional, Herrera-Siklody, Claudia, additional, Cook, Stephane, additional, Goy, Jean-Jacques, additional, Roguelov, Christan, additional, Girod, Grégoire, additional, Rubimbura, Vladimir, additional, Dupré, Marion, additional, Eeckhout, Eric, additional, Pruvot, Etienne, additional, Muller, Olivier, additional, and Pascale, Patrizio, additional

Published
2022
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12. Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters

Author

Pagnoni, Mattia, primary, Meier, David, additional, Luca, Adrian, additional, Fournier, Stephane, additional, Aminfar, Farhang, additional, Gentil, Pascale, additional, Haddad, Christelle, additional, Domenichini, Giulia, additional, Le Bloa, Mathieu, additional, Herrera-Siklody, Claudia, additional, Cook, Stephane, additional, Goy, Jean-Jacques, additional, Roguelov, Christan, additional, Girod, Grégoire, additional, Rubimbura, Vladimir, additional, Dupré, Marion, additional, Eeckhout, Eric, additional, Pruvot, Etienne, additional, Muller, Olivier, additional, and Pascale, Patrizio, additional

Published
2022
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13. Reliability and Safety of a Side-Branch Jailed Second-Generation Optical-Pressure Guidewire in a Physiology-Guided Bifurcation-PCI In Vitro Model

Author

Rubimbura, Vladimir, Johnson, Nils, van't Veer, Marcel, Adjedj, Julien, Fournier, Stephane, Dupré, Marion, De Bruyne, Bernard, Eeckhout, Eric, Muller, Olivier, Eindhoven MedTech Innovation Center, and Cardiovascular Biomechanics

Subjects
Fractional Flow Reserve, Myocardial, Treatment Outcome, Coronary Artery Disease/therapy, Coronary Vessels/diagnostic imaging, Humans, Reproducibility of Results, Stents, Coronary Angiography, Coronary Stenosis/diagnosis, Percutaneous Coronary Intervention/adverse effects
Abstract

BACKGROUND: The treatment of a coronary bifurcation with a single stent (the provisional stenting technique) is associated with a good outcome in most cases. In the majority of cases, after provisional stenting technique, a residual significant angiographic stenosis is associated with the absence of ischemia when fractional flow reserve (FFR) is measured. Jailing an optical pressure guidewire in the side branch (SB) could potentially reduce unnecessary SB interventions after provisional stenting technique. The aim of this study was to compare distal pressure to aortic pressure ratio (Pd/Pa) measurements between 2 second-generation optical pressure guidewires in bifurcation treatment-a jailed wire (JW) and a second free-floating wire (FW) advanced into the SB after stenting. METHODS: In an in vitro bifurcation hydrodynamic model with pressure sensors, a JW was advanced into the SB and the FW into the main branch. Bifurcation stenting is performed with the proximal optimization technique (POT)-side-POT technique using a 3.0 x 22-mm stent, a 4.0 x 12-mm noncompliant balloon for the POT, and a 2.5 x 12-mm semicompliant balloon for the SB opening. The same steps were performed in a second model where a surgical clamp was placed in the main vessel to lower overall absolute values pressures. RESULTS: A strong correlation was found between JW and FW values (Pearson's coefficient, r=0.91). All wires could be safely retrieved. CONCLUSION: In bifurcation stenting, the Pd/Pa value of a second-generation optical pressure guidewire jailed in the SB is reliable compared with a FW inserted after stent implantation.

Published
2022

15. Overview of the RGD-Based PET Agents Use in Patients With Cardiovascular Diseases: A Systematic Review

Author

Dietz, Matthieu, primary, Kamani, Christel H., additional, Dunet, Vincent, additional, Fournier, Stephane, additional, Rubimbura, Vladimir, additional, Testart Dardel, Nathalie, additional, Schaefer, Ana, additional, Jreige, Mario, additional, Boughdad, Sarah, additional, Nicod Lalonde, Marie, additional, Schaefer, Niklaus, additional, Mewton, Nathan, additional, Prior, John O., additional, and Treglia, Giorgio, additional

Published
2022
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18. Future culprit detection based on angiography-derived FFR

Author

Pagnoni, Mattia, Meier, David, Candreva, Alessandro, Maillard, Luc, Adjedj, Julien, Collet, Carlos, Mahendiran, Thabo, Cook, Stephane, Mujcinovic, Alma, Dupré, Marion, Rubimbura, Vladimir, Roguelov, Christan, Eeckhout, Eric, De Bruyne, Bernard, Muller, Olivier, Fournier, Stephane, University of Zurich, and Fournier, Stephane

Subjects
10209 Clinic for Cardiology, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2021

19. Comparison of the Prognostic Value of Global and Regional Myocardial Flow Capacity Radius, Myocardial Flow Reserve, and Stress Myocardial Blood Flow Using Rubidium-82 with SiPM PET/CT

Author

DIETZ, Matthieu, primary, Kamani, Christel H, additional, Allenbach, Gilles, additional, Rubimbura, Vladimir, additional, Fournier, Stephane, additional, Lalonde, Marie Nicod, additional, Schaefer, Niklaus, additional, Eeckhout, Eric, additional, Muller, Olivier, additional, and Prior, John O, additional

Published
2021
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20. Transcarotid Access Versus Transfemoral Access for Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis

Author

Lu, Henri, primary, Monney, Pierre, additional, Hullin, Roger, additional, Fournier, Stephane, additional, Roguelov, Christian, additional, Eeckhout, Eric, additional, Rubimbura, Vladimir, additional, Faroux, Laurent, additional, Barrier, Adelin, additional, Muller, Olivier, additional, and Kirsch, Matthias, additional

Published
2021
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21. Future culprit detection based on angiography‐derived FFR

Author

Pagnoni, Mattia, primary, Meier, David, additional, Candreva, Alessandro, additional, Maillard, Luc, additional, Adjedj, Julien, additional, Collet, Carlos, additional, Mahendiran, Thabo, additional, Cook, Stephane, additional, Mujcinovic, Alma, additional, Dupré, Marion, additional, Rubimbura, Vladimir, additional, Roguelov, Christan, additional, Eeckhout, Eric, additional, De Bruyne, Bernard, additional, Muller, Olivier, additional, and Fournier, Stephane, additional

Published
2021
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26. Quantitative flow ratio virtual stenting and post stenting correlations to post stenting fractional flow reserve measurements from the DOCTORS (Does Optical Coherence Tomography Optimize Results of Stenting) study population

Author

Rubimbura, Vladimir, primary, Guillon, Benoit, additional, Fournier, Stéphane, additional, Amabile, Nicolas, additional, Chi Pan, Chan, additional, Combaret, Nicolas, additional, Eeckhout, Eric, additional, Kibler, Marion, additional, Silvain, Johanne, additional, Wijns, William, additional, Schiele, Francois, additional, Muller, Olivier, additional, Meneveau, Nicolas, additional, and Adjedj, Julien, additional

Published
2019
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27. Outcomes and safety of same-day discharge after percutaneous coronary intervention: A 10-year single-center study

Author

Rubimbura, Vladimir, primary, Rostain, Laura, additional, Duval, Anne-Marie, additional, Akakpo, Servais, additional, Boukantar, Madjid, additional, Boiron, Philippe, additional, Mouillet, Gauthier, additional, Gallet, Romain, additional, Belarbi, Abdelkaoui, additional, Le Corvoisier, Philippe, additional, Dubois-Randé, Jean-Luc, additional, and Teiger, Emmanuel, additional

Published
2019
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28. Quantitative flow ratio virtual stenting and post stenting correlations to post stenting fractional flow reserve measurements from the DOCTORS (Does Optical Coherence Tomography Optimize Results of Stenting) study population.

Author

Rubimbura, Vladimir, Guillon, Benoit, Fournier, Stéphane, Amabile, Nicolas, Chi Pan, Chan, Combaret, Nicolas, Eeckhout, Eric, Kibler, Marion, Silvain, Johanne, Wijns, William, Schiele, Francois, Muller, Olivier, Meneveau, Nicolas, and Adjedj, Julien

Published
2020
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31. Angio-Seal Vascular Closure Device for Percutaneous Management of Iatrogenic Right Ventricular Perforation During Pericardiocentesis.

Author

Skalidis I, Rubimbura V, and Eeckhout E

Subjects
Humans, Treatment Outcome, Vascular Closure Devices, Male, Pericardial Effusion etiology, Pericardial Effusion therapy, Pericardial Effusion diagnostic imaging, Equipment Design, Hemodynamics, Hemorrhage etiology, Hemorrhage therapy, Female, Aged, Pericardiocentesis, Iatrogenic Disease, Heart Injuries etiology, Heart Injuries therapy, Heart Injuries diagnostic imaging, Hemostatic Techniques instrumentation, Hemostatic Techniques adverse effects, Heart Ventricles injuries, Heart Ventricles diagnostic imaging
Abstract

This case report presents an instance of iatrogenic right ventricular perforation during pericardial paracentesis, a rare complication with potentially fatal consequences. Despite initial unsuccessful pericardial drainage, successful closure of the perforation was achieved using an Angio-Seal vascular closure device, leading to cessation of hemorrhage and resolution of hemodynamic instability. The case highlights the efficacy of Angio-Seal in managing such complications, emphasizing its utility in complex clinical scenarios involving pericardial interventions., (© 2024 Wiley Periodicals LLC.)

Published
2025
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32. Natural History of Myocardial α v β 3 Integrin Expression After Acute Myocardial Infarction: Correlation with Changes in Myocardial Blood Flow.

Author

Dietz M, Kamani CH, Bousige C, Dunet V, Delage J, Rubimbura V, Nicod Lalonde M, Treglia G, Schaefer N, Nammas W, Saraste A, Knuuti J, Mewton N, and Prior JO

Subjects
Humans, Male, Female, Middle Aged, Aged, Heterocyclic Compounds, 1-Ring, Prospective Studies, Oligopeptides metabolism, Rubidium Radioisotopes, Acetates, Integrin alphaVbeta3 metabolism, Myocardial Infarction diagnostic imaging, Myocardial Infarction metabolism, Myocardial Infarction physiopathology, Positron Emission Tomography Computed Tomography, Coronary Circulation, Myocardium metabolism
Abstract

Angiogenesis is an essential part of the cardiac repair process after myocardial infarction, but its spatiotemporal dynamics remain to be fully deciphered. 68 Ga-NODAGA-Arg-Gly-Asp (RGD) is a PET tracer targeting α v β 3 integrin expression, which is a marker of angiogenesis. Methods: In this prospective single-center trial, we aimed to monitor angiogenesis through myocardial integrin α v β 3 expression in 20 patients with ST-segment elevation myocardial infarction (STEMI). In addition, the correlations between the expression levels of myocardial α v β 3 integrin and the subsequent changes in 82 Rb PET/CT parameters, including rest and stress myocardial blood flow (MBF), myocardial flow reserve (MFR), and wall motion abnormalities, were assessed. The patients underwent 68 Ga-NODAGA-RGD PET/CT and rest and stress 82 Rb-PET/CT at 1 wk, 1 mo, and 3 mo after STEMI. To assess 68 Ga-NODAGA-RGD uptake, the summed rest 82 Rb and 68 Ga-NODAGA-RGD images were coregistered, and segmental SUVs were calculated (RGD SUV). Results: At 1 wk after STEMI, 19 participants (95%) presented increased 68 Ga-NODAGA-RGD uptake in the infarcted myocardium. Seventeen participants completed the full imaging series. The values of the RGD SUV in the infarcted myocardium were stable 1 mo after STEMI (1 wk vs. 1 mo, 1.47 g/mL [interquartile range (IQR), 1.37-1.64 g/mL] vs. 1.47 g/mL [IQR, 1.30-1.66 g/mL]; P = 0.9), followed by a significant partial decrease at 3 mo (1.32 g/mL [IQR, 1.12-1.71 g/mL]; P = 0.011 vs. 1 wk and 0.018 vs. 1 mo). In segment-based analysis, positive correlations were found between RGD SUV at 1 wk and the subsequent changes in stress MBF (Spearman ρ: r = 0.17, P = 0.0033) and MFR (Spearman ρ: r = 0.31, P < 0.0001) at 1 mo. A negative correlation was found between RGD SUV at 1 wk and the subsequent changes in wall motion abnormalities at 3 mo (Spearman ρ: r = - 0.12, P = 0.035). Conclusion: The present study found that α v β 3 integrin expression is significantly increased in the infarcted myocardium 1 wk after STEMI. This expression remains stable after 1 mo and partially decreases after 3 mo. Initial α v β 3 integrin expression at 1 wk is significantly weakly correlated with subsequent improvements in stress MBF, MFR, and wall motion analysis., (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2024
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33. [Ischemia : when the ECG do not tell us everything].

Author

Rubimbura V, Barras N, Dupré M, and Delabays A

Subjects
Humans, Ischemia, Coronary Angiography, Electrocardiography, Non-ST Elevated Myocardial Infarction diagnosis, Non-ST Elevated Myocardial Infarction therapy, Acute Coronary Syndrome diagnosis
Abstract

The electrocardiogram recording, when an acute coronary syndrome is suspected, is of paramount importance as the modifications of the ST segment confirms the diagnosis of STEMI (ST-elevation myocardial infarction) which needs immediate treatment, or NSTEMI (Non-ST elevation myocardial infarction). In case of NSTEMI, the invasive procedure is generally performed in the first 24 to 72 hours. However, one patient in four present an acute occluded artery at the time of the coronary angiography and this is associated with a worse outcome. In this article, we describe an emblematic case, discuss the worse outcome of these patients and explore some ways to prevent this problem., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2023
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34. Reliability and Safety of a Side-Branch Jailed Second-Generation Optical-Pressure Guidewire in a Physiology-Guided Bifurcation-PCI In Vitro Model.

Author

Rubimbura V, Johnson N, Van't Veer M, Adjedj J, Fournier S, Dupré M, De Bruyne B, Eeckhout E, and Muller O

Subjects
Coronary Angiography, Coronary Vessels diagnostic imaging, Coronary Vessels surgery, Humans, Reproducibility of Results, Stents, Treatment Outcome, Coronary Artery Disease therapy, Coronary Stenosis diagnosis, Coronary Stenosis surgery, Fractional Flow Reserve, Myocardial, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods
Abstract

Background: The treatment of a coronary bifurcation with a single stent (the provisional stenting technique) is associated with a good outcome in most cases. In the majority of cases, after provisional stenting technique, a residual significant angiographic stenosis is associated with the absence of ischemia when fractional flow reserve (FFR) is measured. Jailing an optical pressure guidewire in the side branch (SB) could potentially reduce unnecessary SB interventions after provisional stenting technique. The aim of this study was to compare distal pressure to aortic pressure ratio (Pd/Pa) measurements between 2 second-generation optical pressure guidewires in bifurcation treatment-a jailed wire (JW) and a second free-floating wire (FW) advanced into the SB after stenting., Methods: In an in vitro bifurcation hydrodynamic model with pressure sensors, a JW was advanced into the SB and the FW into the main branch. Bifurcation stenting is performed with the proximal optimization technique (POT)-side-POT technique using a 3.0 x 22-mm stent, a 4.0 x 12-mm noncompliant balloon for the POT, and a 2.5 x 12-mm semicompliant balloon for the SB opening. The same steps were performed in a second model where a surgical clamp was placed in the main vessel to lower overall absolute values pressures., Results: A strong correlation was found between JW and FW values (Pearson's coefficient, r=0.91). All wires could be safely retrieved., Conclusion: In bifurcation stenting, the Pd/Pa value of a second-generation optical pressure guidewire jailed in the SB is reliable compared with a FW inserted after stent implantation.

Published
2022

35. [Takotsubo syndrome in a peripheral hospital: not always typical].

Author

Barras N, Rubimbura V, and Delabays A

Subjects
Consensus, Diagnostic Imaging, Hospitals, Humans, Prognosis, Takotsubo Cardiomyopathy diagnosis
Abstract

In this paper, we describe the clinical presentation of 2 patients with atypical Takotsubo syndrome recently observed in our hospital. It is the occasion de review the clinical characteristics, the biological markers, the imaging clues as well as the diagnosis criteria, the treatment algorithm and the prognostic of this disease, first described 30 years ago by our Japanese colleagues. The current knowledge of this recently summarized entity in an international expert consensus document is the main reference of this presentation., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2021

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