101 results on '"Roy, Pampa"'
Search Results
2. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort
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Pellegrini, Cristina, Botta, Francesca, Massi, Daniela, Martorelli, Claudia, Facchetti, Fabio, Gandini, Sara, Maisonneuve, Patrick, Avril, Marie-Françoise, Demenais, Florence, Paillerets, Brigitte Bressac-de, Hoiom, Veronica, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Gallagher, Richard P, Marrett, Loraine, Zanetti, Roberto, Dwyer, Terence, Thomas, Nancy E, Begg, Colin B, Berwick, Marianne, Puig, Susana, Potrony, Miriam, Nagore, Eduardo, Ghiorzo, Paola, Menin, Chiara, Manganoni, Ausilia Maria, Rodolfo, Monica, Brugnara, Sonia, Passoni, Emanuela, Sekulovic, Lidija Kandolf, Baldini, Federica, Guida, Gabriella, Stratigos, Alexandros, Ozdemir, Fezal, Ayala, Fabrizio, Fernandez-de-Misa, Ricardo, Quaglino, Pietro, Ribas, Gloria, Romanini, Antonella, Migliano, Emilia, Stanganelli, Ignazio, Kanetsky, Peter A, Pizzichetta, Maria Antonietta, García-Borrón, Jose Carlos, Nan, Hongmei, Landi, Maria Teresa, Little, Julian, Newton-Bishop, Julia, Sera, Francesco, Fargnoli, Maria Concetta, Raimondi, Sara, Group, IMI Study, Alaibac, Mauro, Ferrari, Andrea, Valeri, Barbara, Sicher, Mariacristina, Mangiola, Daniela, Nazzaro, Gianluca, Tosti, Giulio, Mazzarol, Giovanni, Giudice, Giuseppe, Ribero, Simone, Astrua, Chiara, Mazzoni, Laura, Group, GEM Study, Orlow, Irene, Mujumdar, Urvi, Hummer, Amanda, Busam, Klaus, Roy, Pampa, Canchola, Rebecca, Clas, Brian, Cotignola, Javiar, Monroe, Yvette, Armstrong, Bruce, Kricker, Anne, Litchfield, Melisa, Tucker, Paul, Stephens, Nicola, Switzer, Teresa, Theis, Beth, From, Lynn, Chowdhury, Noori, Vanasse, Louise, Purdue, Mark, Northrup, David, Rosso, Stefano, Sacerdote, Carlotta, Leighton, Nancy, Gildea, Maureen, Bonner, Joe, Jeter, Joanne, Klotz, Judith, Wilcox, Homer, Weiss, Helen, Millikan, Robert, Mattingly, Dianne, and Player, Jon
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Clinical Research ,Pediatric ,Genetics ,Prevention ,Cancer ,Adolescent ,Adult ,Aged ,Biomarkers ,Tumor ,Case-Control Studies ,Child ,Female ,Genetic Predisposition to Disease ,Germ-Line Mutation ,Humans ,Logistic Models ,Male ,Melanoma ,Middle Aged ,Odds Ratio ,Polymorphism ,Genetic ,Receptor ,Melanocortin ,Type 1 ,Retrospective Studies ,Skin Neoplasms ,IMI Study Group ,GEM Study Group ,M-SKIP Study Group - Abstract
BackgroundGermline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.MethodsIn this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger.FindingsWe analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02-2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06-3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05-2·44; p=0·04) and Asp294His (2·15, 1·05-4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants.InterpretationOur pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies.FundingSPD-Pilot/Project-Award-2015; AIRC-MFAG-11831.
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- 2019
3. Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes
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Thomas, Nancy E, Edmiston, Sharon N, Orlow, Irene, Kanetsky, Peter A, Luo, Li, Gibbs, David C, Parrish, Eloise A, Hao, Honglin, Busam, Klaus J, Armstrong, Bruce K, Kricker, Anne, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Gallagher, Richard P, Zanetti, Roberto, Rosso, Stefano, Sacchetto, Lidia, Dwyer, Terence, Ollila, David W, Begg, Colin B, Berwick, Marianne, Conway, Kathleen, Begg, Colin, Roy, Pampa, Reiner, Anne, Leong, Siok, Guerrero, Sergio Corrales, Sadeghi, Keimya, Boyce, Tawny W, Venn, Alison, Tucker, Paul, Marrett, Loraine D, From, Lynn, Huang, Shu-Chen, Groben, Pamela A, Parrish, Eloise, Frank, Jill S, Rebbeck, Timothy R, Taylor, Julia Lee, and Madronich, Sasha
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Human Genome ,Cancer ,Genetic Testing ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Aged ,Female ,GTP Phosphohydrolases ,Genetic Association Studies ,Genotype ,Group VI Phospholipases A2 ,Humans ,Interferon Regulatory Factors ,Male ,Melanoma ,Membrane Proteins ,Middle Aged ,Mutation ,Polymorphism ,Single Nucleotide ,Proto-Oncogene Proteins B-raf ,Risk ,Skin Neoplasms ,GEM Study Group ,Clinical Sciences ,Dermatology & Venereal Diseases ,Clinical sciences - Abstract
BRAF and NRAS mutations arise early in melanoma development, but their associations with low-penetrance melanoma susceptibility loci remain unknown. In the Genes, Environment and Melanoma Study, 1,223 European-origin participants had their incident invasive primary melanomas screened for BRAF/NRAS mutations and germline DNA genotyped for 47 single-nucleotide polymorphisms identified as low-penetrant melanoma-risk variants. We used multinomial logistic regression to simultaneously examine each single-nucleotide polymorphism's relationship to BRAF V600E, BRAF V600K, BRAF other, and NRAS+ relative to BRAF-/NRAS- melanoma adjusted for study features. IRF4 rs12203592*T was associated with BRAF V600E (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.43-0.79) and V600K (OR = 0.65, 95% CI = 0.41-1.03), but not BRAF other or NRAS+ melanoma. A global test of etiologic heterogeneity (Pglobal = 0.001) passed false discovery (Pglobal = 0.0026). PLA2G6 rs132985*T was associated with BRAF V600E (OR = 1.32, 95% CI = 1.05-1.67) and BRAF other (OR = 1.82, 95% CI = 1.11-2.98), but not BRAF V600K or NRAS+ melanoma. The test for etiologic heterogeneity (Pglobal) was 0.005. The IRF4 rs12203592 associations were slightly attenuated after adjustment for melanoma-risk phenotypes. The PLA2G6 rs132985 associations were independent of phenotypes. IRF4 and PLA2G6 inherited genotypes may influence melanoma BRAF/NRAS subtype development.
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- 2018
4. Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma
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Thomas, Nancy E, Edmiston, Sharon N, Kanetsky, Peter A, Busam, Klaus J, Kricker, Anne, Armstrong, Bruce K, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Luo, Li, Orlow, Irene, Reiner, Anne S, Gallagher, Richard P, Zanetti, Roberto, Rosso, Stefano, Sacchetto, Lidia, Dwyer, Terence, Parrish, Eloise A, Hao, Honglin, Gibbs, David C, Frank, Jill S, Ollila, David W, Begg, Colin B, Berwick, Marianne, Conway, Kathleen, Roy, Pampa, Patel, Himali, Paine, Susan, Venn, Alison, Tucker, Paul, Marrett, Loraine D, From, Lynn, Huang, Shu-Chen, Groben, Pamela A, Parrish, Eloise, Bramson, Jennifer I, Rebbeck, Timothy R, Taylor, Julia Lee, and Madronich, Sasha
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Genetics ,Adult ,Aged ,Australia ,Female ,GTP Phosphohydrolases ,Genotype ,Humans ,Male ,Melanoma ,Membrane Proteins ,Middle Aged ,Mutation ,Phenotype ,Proto-Oncogene Proteins B-raf ,Receptor ,Melanocortin ,Type 1 ,Skin Neoplasms ,United States ,GEM Study Group ,Clinical Sciences ,Dermatology & Venereal Diseases ,Clinical sciences - Abstract
Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF+ were associated with younger age, blond/light brown hair, increased nevi, and less freckling, and NRAS+ with older age relative to the wild type (BRAF-/NRAS-) melanomas (all P < 0.05). Comparing specific BRAF subtypes to the wild type, BRAF V600E was associated with younger age, blond/light brown hair, and increased nevi and V600K with increased nevi and less freckling (all P < 0.05). MC1R was positively associated with BRAF V600E cases but only among individuals with darker phototypes or darker hair (Pinteraction < 0.05) but inversely associated with BRAF V600K (Ptrend = 0.006) with no significant effect modification by phenotypes. These results support distinct etiologies for BRAF V600E, BRAF V600K, NRAS+, and wild-type melanomas. MC1R's associations with BRAF V600E cases limited to individuals with darker phenotypes indicate that MC1R genotypes specifically provide information about BRAF V600E melanoma risk in those not considered high risk based on phenotype. Our results also suggest that melanin pathways deserve further study in BRAF V600E melanomagenesis.
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- 2017
5. Variants in autophagy‐related genes and clinical characteristics in melanoma: a population‐based study
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White, Kirsten AM, Luo, Li, Thompson, Todd A, Torres, Salina, Hu, Chien‐An Andy, Thomas, Nancy E, Lilyquist, Jenna, Anton‐Culver, Hoda, Gruber, Stephen B, From, Lynn, Busam, Klaus J, Orlow, Irene, Kanetsky, Peter A, Marrett, Loraine D, Gallagher, Richard P, Sacchetto, Lidia, Rosso, Stefano, Dwyer, Terence, Cust, Anne E, Begg, Colin B, Berwick, Marianne, Mujumdar, Urvi, Roy, Pampa, Armstrong, Bruce, Kricker, Anne, Litchfield, Melisa, Tucker, Paul, Venn, Alison, Stephens, Nicola, Switzer, Teresa, Marrett, Loraine, Theis, Elizabeth, Chowdhury, Noori, Vanasse, Louise, Zanetti, Roberto, Sacerdote, Carlotta, Leighton, Nancy, Jeter, Joanne, Klotz, Judith, Wilcox, Homer, Weiss, Helen, Mattingly, Dianne, Player, Jon, Rebbeck, Timothy, Walker, Amy, Panossian, Saarene, Taylor, Julia Lee, and Madronich, Sasha
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Genetics ,Clinical Research ,Aetiology ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,2.1 Biological and endogenous factors ,Adult ,Aged ,Alleles ,Autophagy ,Autophagy-Related Proteins ,Female ,Genetic Predisposition to Disease ,Genetic Variation ,Genotype ,Humans ,Male ,Melanoma ,Middle Aged ,Models ,Biological ,Neoplasm Staging ,Odds Ratio ,Polymorphism ,Single Nucleotide ,Population Surveillance ,ATG16L1 ,autophagy ,melanoma ,polymorphism ,SNP ,GEM Study Group ,ATG16L1 ,SNP ,Biochemistry and Cell Biology ,Oncology and carcinogenesis - Abstract
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have been investigated in relation to melanoma progression. We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of melanoma. DNA from 911 melanoma patients was genotyped. An association was identified between (GG) (rs2241880) and earlier stage at diagnosis (OR 0.47; 95% Confidence Intervals (CI) = 0.27-0.81, P = 0.02) and a decrease in Breslow thickness (P = 0.03). The ATG16L heterozygous genotype (AG) (rs2241880) was associated with younger age at diagnosis (P = 0.02). Two SNPs in ATG5 were found to be associated with increased stage (rs2245214 CG, OR 1.47; 95% CI = 1.11-1.94, P = 0.03; rs510432 CC, OR 1.84; 95% CI = 1.12-3.02, P = 0.05). Finally, we identified inverse associations between ATG5 (GG rs2245214) and melanomas on the scalp or neck (OR 0.20, 95% CI = 0.05-0.86, P = 0.03); ATG10 (CC) (rs1864182) and brisk tumor infiltrating lymphocytes (TILs) (OR 0.42; 95% CI = 0.21-0.88, P = 0.02), and ATG5 (CC) (rs510432) with nonbrisk TILs (OR 0.55; 95% CI = 0.34-0.87, P = 0.01). Our data suggest that ATG SNPs might be differentially associated with specific host and tumor characteristics including age at diagnosis, TILs, and stage. These associations may be critical to understanding the role of autophagy in cancer, and further investigation will help characterize the contribution of these variants to melanoma progression.
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- 2016
6. Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study
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Orlow, Irene, Reiner, Anne S, Thomas, Nancy E, Roy, Pampa, Kanetsky, Peter A, Luo, Li, Paine, Susan, Armstrong, Bruce K, Kricker, Anne, Marrett, Loraine D, Rosso, Stefano, Zanetti, Roberto, Gruber, Stephen B, Anton-Culver, Hoda, Gallagher, Richard P, Dwyer, Terence, Busam, Klaus, Begg, Colin B, and Berwick, Marianne
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Genetics ,Nutrition ,Cancer ,Genetic Testing ,Australia ,Canada ,Female ,Genotype ,Haplotypes ,Humans ,Italy ,Male ,Melanoma ,Polymorphism ,Single Nucleotide ,Proportional Hazards Models ,Receptors ,Calcitriol ,Skin Neoplasms ,United States ,GEM Study Group ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values < 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics.
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- 2016
7. Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes
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Berwick, Marianne, Begg, Colin, Orlow, Irene, Busam, Klaus J., Roy, Pampa, Reiner, Anne, Leong, Siok, Guerrero, Sergio Corrales, Sadeghi, Keimya, Luo, Li, Boyce, Tawny W., Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Anton-Culver, Hoda, Gruber, Stephen B., Huang, Shu-Chen, Thomas, Nancy E., Conway, Kathleen, Ollila, David W., Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Rebbeck, Timothy R., Kanetsky, Peter A., Lee Taylor, Julia, Madronich, Sasha, Parrish, Eloise A., Sacchetto, Lidia, and Begg, Colin B.
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- 2018
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8. Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma
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Berwick, Marianne, Begg, Colin B., Orlow, Irene, Busam, Klaus J., Reiner, Anne S., Roy, Pampa, Patel, Himali, Luo, Li, Paine, Susan, Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Anton-Culver, Hoda, Gruber, Stephen B., Huang, Shu-Chen, Thomas, Nancy E., Ollila, David W., Conway, Kathleen, Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Bramson, Jennifer I., Rebbeck, Timothy R., Kanetsky, Peter A., Lee Taylor, Julia, Madronich, Sasha, Sacchetto, Lidia, and Parrish, Eloise A.
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- 2017
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9. CDKN2A Germline Mutations in Individuals with Cutaneous Malignant Melanoma
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Orlow, Irene, Begg, Colin B, Cotignola, Javier, Roy, Pampa, Hummer, Amanda J, Clas, Brian A, Mujumdar, Urvi, Canchola, Rebecca, Armstrong, Bruce K, Kricker, Anne, Marrett, Loraine D, Millikan, Robert C, Gruber, Stephen B, Anton-Culver, Hoda, Zanetti, Roberto, Gallagher, Richard P, Dwyer, Terence, Rebbeck, Timothy R, Kanetsky, Peter A, Wilcox, Homer, Busam, Klaus, From, Lynn, Berwick, Marianne, and Group, for the GEM Study
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Genetic Testing ,Climate-Related Exposures and Conditions ,Clinical Research ,Rare Diseases ,Cancer ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Cyclin-Dependent Kinase Inhibitor p16 ,DNA ,Neoplasm ,Exons ,Genetic Predisposition to Disease ,Germ-Line Mutation ,Humans ,Melanoma ,Risk Factors ,Skin Neoplasms ,GEM Study Group ,Clinical Sciences ,Oncology and Carcinogenesis ,Dermatology & Venereal Diseases - Abstract
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptibility gene based on the presence of germline mutations in high-risk melanoma families. In this study, we sought to identify and characterize the spectrum of CDKN2A mutations affecting p16 inhibitor of cyclin-dependent kinase type 4 (INK4a) in individuals with melanoma using a population-based study design. DNA samples from 1189 individuals with incident multiple primary melanoma (MPM) and 2424 with incident single primary melanoma unselected for family history of melanoma were available for screening of CDKN2A (p16INK4a) mutations. Variants were classified for functional impact based on intragenic position, existing functional data, sequence, and structural analysis. The impact of individual mutations and functional groupings was assessed by comparing frequencies in cases of MPM versus cases with a single first primary melanoma, and by comparing the reported incidence rates in first-degree relatives. Our results show that mutations occur infrequently in these high-risk groups, and that they occur mainly in exons 1alpha and 2. Rare coding variants with putative functional impact are observed to increase substantially the risk of melanoma. With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk.
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- 2007
10. Supplementary Tables 1 and 2 from Vitamin D Receptor Gene Haplotypes and Polymorphisms and Risk of Breast Cancer: A Nested Case–Control Study
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Engel, Lawrence S., primary, Orlow, Irene, primary, Sima, Camelia S., primary, Satagopan, Jaya, primary, Mujumdar, Urvi, primary, Roy, Pampa, primary, Yoo, Sarah, primary, Sandler, Dale P., primary, and Alavanja, Michael C., primary
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- 2023
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11. Data from Vitamin D Receptor Gene Haplotypes and Polymorphisms and Risk of Breast Cancer: A Nested Case–Control Study
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Engel, Lawrence S., primary, Orlow, Irene, primary, Sima, Camelia S., primary, Satagopan, Jaya, primary, Mujumdar, Urvi, primary, Roy, Pampa, primary, Yoo, Sarah, primary, Sandler, Dale P., primary, and Alavanja, Michael C., primary
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- 2023
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12. The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
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Orlow, Irene, Shi, Yang, Kanetsky, Peter A., Thomas, Nancy E., Luo, Li, Corrales‐Guerrero, Sergio, Cust, Anne E., Sacchetto, Lidia, Zanetti, Roberto, Rosso, Stefano, Armstrong, Bruce K., Dwyer, Terence, Venn, Alison, Gallagher, Richard P., Gruber, Stephen B., Marrett, Loraine D., Anton‐Culver, Hoda, Busam, Klaus, Begg, Colin B., Berwick, Marianne, Roy, Pampa, Patel, Himali, Yoo, Sarah, Reiner, Anne, Paine, Susan, Kricker, Anne, Tucker, Paul, From, Lynn, Ollila, David W., Groben, Pamela A., Rebbeck, Timothy R., Taylor, Julia Lee, and Madronich, Sasha
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- 2018
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13. Variants in Hormone Biosynthesis Genes and Risk of Endometrial Cancer
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Olson, Sara H., Orlow, Irene, Bayuga, Sharon, Sima, Camelia, Bandera, Elisa V., Pulick, Katherine, Faulkner, Shameka, Tommasi, Diana, Egan, Daniel, Roy, Pampa, Wilcox, Homer, Asya, Ali, Modica, Ippolito, Asad, Haider, Soslow, Robert, and Zauber, Ann G.
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- 2008
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14. Comparison of community pathologists with expert dermatopathologists evaluating Breslow thickness and histopathologic subtype in a large international population-based study of melanoma
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Berwick, Marianne, Begg, Colin, Orlow, Irene, Busam, Klaus J., Autuori, Isidora, Roy, Pampa, Reiner, Anne, Luo, Li, Boyce, Tawny W., Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Sacchetto, Lidia, Anton-Culver, Hoda, Gruber, Stephen B., Bonner, Joseph D., Thomas, Nancy E., Conway, Kathleen, Ollila, David W., Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Rebbeck, Timothy R., Kanetsky, Peter A., Taylor, Julia Lee, Madronich, Sasha, Yardman-Frank, Joseph Michael, Bronner, Baillie, Busam, Klaus, Groben, Pam, Cust, Anne, Armstrong, Bruce, Marrett, Loraine, Gruber, Stephen, Gallagher, Rick, Dwyer, Terry, Kanetsky, Peter, and Thomas, Nancy
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- 2021
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15. Comparison of community pathologists with expert dermatopathologists evaluating Breslow thickness and histopathologic subtype in a large international population-based study of melanoma
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Yardman-Frank, Joseph Michael, primary, Bronner, Baillie, additional, Rosso, Stefano, additional, From, Lynn, additional, Busam, Klaus, additional, Groben, Pam, additional, Tucker, Paul, additional, Cust, Anne, additional, Armstrong, Bruce, additional, Kricker, Anne, additional, Marrett, Loraine, additional, Anton-Culver, Hoda, additional, Gruber, Stephen, additional, Gallagher, Rick, additional, Zanetti, Roberto, additional, Sacchetto, Lidia, additional, Dwyer, Terry, additional, Venn, Alison, additional, Orlow, Irene, additional, Kanetsky, Peter, additional, Luo, Li, additional, Thomas, Nancy, additional, Begg, Colin, additional, Berwick, Marianne, additional, Busam, Klaus J., additional, Autuori, Isidora, additional, Roy, Pampa, additional, Reiner, Anne, additional, Boyce, Tawny W., additional, Cust, Anne E., additional, Armstrong, Bruce K., additional, Dwyer, Terence, additional, Gallagher, Richard P., additional, Marrett, Loraine D., additional, Gruber, Stephen B., additional, Bonner, Joseph D., additional, Thomas, Nancy E., additional, Conway, Kathleen, additional, Ollila, David W., additional, Groben, Pamela A., additional, Edmiston, Sharon N., additional, Hao, Honglin, additional, Parrish, Eloise, additional, Frank, Jill S., additional, Gibbs, David C., additional, Rebbeck, Timothy R., additional, Kanetsky, Peter A., additional, Taylor, Julia Lee, additional, and Madronich, Sasha, additional
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- 2021
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16. Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma
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Berwick, Marianne, Begg, Colin, Orlow, Irene, Busam, Klaus J., Roy, Pampa, Sharma, Ajay, La Pilla, Emily, Yoo, Sarah, Rayar, Jaipreet, Reiner, Anne, Luo, Li, Boyce, Tawny W., Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Anton-Culver, Hoda, Gruber, Stephen B., Huang, Shu-Chen, Thomas, Nancy E., Conway, Kathleen, Ollila, David W., Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Rebbeck, Timothy R., Kanetsky, Peter A., Lee Taylor, Julia, Madronich, Sasha, Gibbs, David Corley, Vernali, Steven, Powell, Helen B., Sacchetto, Lidia, and Begg, Colin B.
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- 2020
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17. Vitamin D receptor polymorphisms in patients with cutaneous melanoma
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Orlow, Irene, Roy, Pampa, Reiner, Anne S., Yoo, Sarah, Patel, Himali, Paine, Susan, Armstrong, Bruce K., Kricker, Anne, Marrett, Loraine D., Millikan, Robert C., Thomas, Nancy E., Gruber, Stephen B., Anton-Culver, Hoda, Rosso, Stefano, Gallagher, Richard P., Dwyer, Terence, Kanetsky, Peter A., Busam, Klaus, From, Lynn, Begg, Colin B., and Berwick, Marianne
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- 2012
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18. Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study
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Berwick, Marianne, Begg, Colin, Orlow, Irene, Busam, Klaus J., Roy, Pampa, Leong, Siok, Corrales-Guerrero, Sergio, Sadeghi, Keimya, Reiner, Anne, Luo, Li, Boyce, Tawny W., Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Lai, Agnes, Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Anton-Culver, Hoda, Gruber, Stephen B., Huang, Shu-Chen, Thomas, Nancy E., Conway, Kathleen, Ollila, David W., Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Rebbeck, Timothy R., Kanetsky, Peter A., Lee Taylor, Julia, Madronich, Sasha, Miles, Jonathan A., Sacchetto, Lidia, Mavinkurve, Vikram, and Begg, Colin B.
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- 2019
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19. Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma
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Gibbs, David Corley, primary, Orlow, Irene, additional, Vernali, Steven, additional, Powell, Helen B., additional, Kanetsky, Peter A., additional, Luo, Li, additional, Busam, Klaus J., additional, Sharma, Ajay, additional, Kricker, Anne, additional, Armstrong, Bruce K., additional, Cust, Anne E., additional, Anton-Culver, Hoda, additional, Gruber, Stephen B., additional, Gallagher, Richard P., additional, Zanetti, Roberto, additional, Rosso, Stefano, additional, Sacchetto, Lidia, additional, Dwyer, Terence, additional, Ollila, David W., additional, Begg, Colin B., additional, Berwick, Marianne, additional, Thomas, Nancy E., additional, Begg, Colin, additional, Roy, Pampa, additional, La Pilla, Emily, additional, Yoo, Sarah, additional, Rayar, Jaipreet, additional, Reiner, Anne, additional, Boyce, Tawny W., additional, Venn, Alison, additional, Tucker, Paul, additional, Marrett, Loraine D., additional, From, Lynn, additional, Huang, Shu-Chen, additional, Conway, Kathleen, additional, Groben, Pamela A., additional, Edmiston, Sharon N., additional, Hao, Honglin, additional, Parrish, Eloise, additional, Frank, Jill S., additional, Gibbs, David C., additional, Rebbeck, Timothy R., additional, Lee Taylor, Julia, additional, and Madronich, Sasha, additional
- Published
- 2020
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20. Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study
- Author
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Miles, Jonathan A., primary, Orlow, Irene, additional, Kanetsky, Peter A., additional, Luo, Li, additional, Cust, Anne E., additional, Armstrong, Bruce K., additional, Kricker, Anne, additional, Anton-Culver, Hoda, additional, Gruber, Stephen B., additional, Gallagher, Richard P., additional, Zanetti, Roberto, additional, Rosso, Stefano, additional, Sacchetto, Lidia, additional, Dwyer, Terence, additional, Gibbs, David C., additional, Busam, Klaus J., additional, Mavinkurve, Vikram, additional, Ollila, David W., additional, Begg, Colin B., additional, Berwick, Marianne, additional, Thomas, Nancy E., additional, Begg, Colin, additional, Roy, Pampa, additional, Leong, Siok, additional, Corrales-Guerrero, Sergio, additional, Sadeghi, Keimya, additional, Reiner, Anne, additional, Boyce, Tawny W., additional, Venn, Alison, additional, Tucker, Paul, additional, Lai, Agnes, additional, Marrett, Loraine D., additional, From, Lynn, additional, Huang, Shu-Chen, additional, Conway, Kathleen, additional, Groben, Pamela A., additional, Edmiston, Sharon N., additional, Hao, Honglin, additional, Parrish, Eloise, additional, Frank, Jill S., additional, Rebbeck, Timothy R., additional, Lee Taylor, Julia, additional, and Madronich, Sasha, additional
- Published
- 2019
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21. Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes
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Albert, Matthew L., Pearce, S. Frieda A., Francisco, Loise M., Sauter, Birthe, Roy, Pampa, Silverstein, Roy L., and Bhardwaj, Nina
- Published
- 1998
22. Sun exposure, vitamin D receptor genetic variants, and risk of breast cancer in the agricultural health study
- Author
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Engel, Lawrence S., Satagopan, Jaya, Sima, Camelia S., Orlow, Irene, Mujumdar, Urvi, Coble, Joseph, Roy, Pampa, Yoo, Sarah, Sandler, Dale P., and Alavanja, Michael C.
- Subjects
Sun exposure -- Health aspects ,Alfacalcidol -- Health aspects ,Calcifediol -- Health aspects ,Vitamin D -- Health aspects ,Breast cancer -- Risk factors -- Environmental aspects ,Agricultural laborers -- Health aspects -- Environmental aspects ,Environmental issues ,Health - Abstract
Background: Epidemiologic evidence suggests a negative relation between sunlight exposure and breast cancer risk. The hypothesized mechanism is sunlight-induced cutaneous synthesis of vitamin D. Objectives: Our goal was to examine sun exposure and its interaction with vitamin D receptor (VDR) gene variants on breast cancer risk. Methods: We examined sun exposure and breast cancer incidence among 31,021 private pesticide applicators' wives, including 578 cases, enrolled in the prospective Agricultural Health Study cohort and followed 8.6 years on average. We estimated interactions between sun exposure, VDR variants, and breast cancer in a nested case--control study comprising 293 cases and 586 matched controls. Information on sun exposure was obtained by questionnaire at cohort enrollment. Relative risks were estimated using Cox proportional hazards regression for the cohort data and conditional logistic regression for the nested cas--control data. Results: We observed a small decrease in breast cancer risk in association with usual sun exposure of [greater than or equal to] 1 hr/day (versus < 1 hr/day) 10 years before the start of follow-up among all participants [hazard ratio (HR) = 0.8; 95% CI: 0.6, 1.0]. The association appeared to be slightly stronger in relation to estrogen receptor--positive tumors (HR = 0.7; 95% CI: 0.5, 0.9) than estrogen receptor--negative tumors (HR = 1.1; 95% CI: 0.6, 2.1). The HR for joint exposure [greater than or equal to] 1 hr/day of sunlight and one VDR haplotype was less than expected given negative HRs for each individual exposure (interaction p-value = 0.07). Conclusion: Our results suggest that sun exposure may be associated with reduced risk of breast cancer, but we did not find clear evidence of modification by VDR variants. Larger studies are warranted, particularly among populations in whom low levels of usual sun exposure can be more precisely characterized., Background Epidemiologic studies have reported a negative relation between sunlight exposure and risk of breast cancer. The hypothesized mechanism for this relationship is sunlight (ultraviolet B)--induced dermal synthesis of vitamin [...]
- Published
- 2014
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23. Validation of Denaturing High Performance Liquid Chromatography as a Rapid Detection Method for the Identification of Human INK4A Gene Mutations
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Orlow, Irene, Roy, Pampa, Barz, Allison, Canchola, Rebecca, Song, Yan, and Berwick, Marianne
- Published
- 2001
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24. Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study
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Johnson, Busam, Klaus, Zanetti, Roberto, Taylor, Gallagher, Richard P., Conway, Hao, Paine, Susan, Orlow, Irene, Gibbs, Gruber, Stephen B., From, Marrett, Loraine D., Kan, Kanetsky, Peter A., Armstrong, Bruce K., Anton-Culver, Hoda, Berwick, Marianne, Ziogas, Reiner, Anne S., Begg, Colin B., Kricker, Anne, Bramson, Groben, Parmar, Madronich, Roy, Pampa, Rebbeck, Rosso, Stefano, Tucker, Thomas, Nancy E., Edmiston, Theis, Dwyer, Terence, Millikan, Ollila, Frank, Parrish, Sturgeon, Venn, Cust, White, and Luo, Li
- Abstract
Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values < 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics.
- Published
- 2016
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25. Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma
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Kan, Donna, Johnson, Timothy, Busam, Klaus J., Kanetsky, Peter A., Millikan, Robert C., Roy, Pampa, Hao, Honglin, Edmiston, Sharon N., Kricker, Anne, Theis, Elizabeth, Madronich, Sasha, Reiner, Anne S., La Pilla, Emily, Cust, Anne E., Paine, Susan, Rebbeck, Timothy R., Frank, Jill S., Berwick, Marianne, Orlow, Irene, Groben, Pamela A., Conway, Kathleen, From, Lynn, Rosso, Stefano, Sharma, Ajay, Anton-Culver, Hoda, Sturgeon, Duveen, Zanetti, Roberto, Ollila, David W., Parrish, Eloise, Bramson, Jennifer I., Tucker, Paul, Luo, Li, Armstrong, Bruce K., Venn, Alison, Taylor, Julia Lee, Begg, Colin B., Marrett, Loraine D., Dwyer, Terence, Gibbs, David C., Gruber, Stephen B., Thomas, Nancy E., Gallagher, Richard P., White, Kirsten, and Ziogas, Argyrios
- Abstract
Recent studies including genome-wide association studies have identified several putative low-penetrance susceptibility loci for melanoma. We sought to determine their generalizability to genetic predisposition for multiple primary melanoma in the international population-based Genes, Environment, and Melanoma (GEM) Study. GEM is a case-control study of 1,206 incident cases of multiple primary melanoma and 2,469 incident first primary melanoma participants as the control group. We investigated the odds of developing multiple primary melanoma for 47 single nucleotide polymorphisms (SNP) from 21 distinct genetic regions previously reported to be associated with melanoma. ORs and 95% CIs were determined using logistic regression models adjusted for baseline features (age, sex, age by sex interaction, and study center). We investigated univariable models and built multivariable models to assess independent effects of SNPs. Eleven SNPs in 6 gene neighborhoods (TERT/CLPTM1L, TYRP1, MTAP, TYR, NCOA6, and MX2) and a PARP1 haplotype were associated with multiple primary melanoma. In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma while NCOA6 rs4911442 approached significance (P = 0.06). The GEM study provides additional evidence for the relevance of these genetic regions to melanoma risk and estimates the magnitude of the observed genetic effect on development of subsequent primary melanoma.
- Published
- 2015
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26. Isolation ofThiobacillus ferrooxidans from various habitats and their growth pattern on solid medium
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Mishra, Ajit K., Roy, Pampa, and Mahapatra, S. S. Roy
- Published
- 1983
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27. MC1Rvariants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort
- Author
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Pellegrini, Cristina, Botta, Francesca, Massi, Daniela, Martorelli, Claudia, Facchetti, Fabio, Gandini, Sara, Maisonneuve, Patrick, Avril, Marie-Françoise, Demenais, Florence, Bressac-de Paillerets, Brigitte, Hoiom, Veronica, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Gallagher, Richard P, Marrett, Loraine, Zanetti, Roberto, Dwyer, Terence, Thomas, Nancy E, Begg, Colin B, Berwick, Marianne, Puig, Susana, Potrony, Miriam, Nagore, Eduardo, Ghiorzo, Paola, Menin, Chiara, Manganoni, Ausilia Maria, Rodolfo, Monica, Brugnara, Sonia, Passoni, Emanuela, Sekulovic, Lidija Kandolf, Baldini, Federica, Guida, Gabriella, Stratigos, Alexandros, Ozdemir, Fezal, Ayala, Fabrizio, Fernandez-de-Misa, Ricardo, Quaglino, Pietro, Ribas, Gloria, Romanini, Antonella, Migliano, Emilia, Stanganelli, Ignazio, Kanetsky, Peter A, Pizzichetta, Maria Antonietta, García-Borrón, Jose Carlos, Nan, Hongmei, Landi, Maria Teresa, Little, Julian, Newton-Bishop, Julia, Sera, Francesco, Fargnoli, Maria Concetta, Raimondi, Sara, Alaibac, Mauro, Ferrari, Andrea, Valeri, Barbara, Sicher, Mariacristina, Mangiola, Daniela, Nazzaro, Gianluca, Tosti, Giulio, Mazzarol, Giovanni, Giudice, Giuseppe, Ribero, Simone, Astrua, Chiara, Romanini, Antonella, Mazzoni, Laura, Orlow, Irene, Mujumdar, Urvi, Hummer, Amanda, Busam, Klaus, Roy, Pampa, Canchola, Rebecca, Clas, Brian, Cotignola, Javiar, Monroe, Yvette, Armstrong, Bruce, Kricker, Anne, Litchfield, Melisa, Tucker, Paul, Stephens, Nicola, Switzer, Teresa, Theis, Beth, From, Lynn, Chowdhury, Noori, Vanasse, Louise, Purdue, Mark, Northrup, David, Rosso, Stefano, Sacerdote, Carlotta, Leighton, Nancy, Gildea, Maureen, Bonner, Joe, Jeter, Joanne, Klotz, Judith, Wilcox, Homer, Weiss, Helen, Millikan, Robert, Mattingly, Dianne, Player, Jon, Tse, Chiu-Kit, Rebbeck, Timothy, Walker, Amy, Panossian, Saarene, Setlow, Richard, Mohrenweiser, Harvey, Autier, Philippe, Han, Jiali, Caini, Saverio, Hofman, Albert, Kayser, Manfred, Liu, Fan, Nijsten, Tamar, Uitterlinden, Andre G., Kumar, Rajiv, Bishop, Tim, Elliott, Faye, Lazovich, DeAnn, Polsky, David, Hansson, Johan, Pastorino, Lorenza, Gruis, Nelleke A., Bouwes Bavinck, Jan Nico, Aguilera, Paula, Badenas, Celia, Carrera, Cristina, Gimenez-Xavier, Pol, Malvehy, Josep, Puig-Butille, Joan Anton, Tell-Marti, Gemma, Blizzard, Leigh, Cochrane, Jennifer, Branicki, Wojciech, Debniak, Tadeusz, Morling, Niels, Johansen, Peter, Mayne, Susan, Bale, Allen, Cartmel, Brenda, Ferrucci, Leah, Pfeiffer, Ruth, Palmieri, Giuseppe, Kypreou, Katerina, Bowcock, Anne, Cornelius, Lynn, Council, M. Laurin, Motokawa, Tomonori, Anno, Sumiko, Helsing, Per, Andresen, Per Arne, Guida, Stefania, and Wong, Terence H.
- Abstract
Germline variants in the melanocortin 1 receptor gene (MC1R)might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1Rvariants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1Rvariants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.
- Published
- 2019
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28. Associations of Cumulative Sun Exposure and Phenotypic Characteristics with Histologic Solar Elastosis
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Tucker, Paul, Marrett, Loraine D., Berwick, Marianne, Mohrenweiser, Harvey, Gildea, Maureen, Litchfield, Melisa, Rebbeck, Timothy R., Hummer, Amanda J., Kricker, Anne, Kanetsky, Peter, Bonner, Joe, Gruber, Stephen B., Anton-Culver, Hoda, Madronich, Sasha, Goumas, Chris, Orlow, Irene, Purdue, Mark, Begg, Colin B., Thomas, Nancy E., Setlow, Richard, Sacerdote, Carlotta, Stephens, Nicola, Cotignola, Javier, Taylor, Julia Lee, Lee-Taylor, Julia, Kanetsky, Peter A., Switzer, Teresa, Monroe, Yvette, Chowdhury, Noori, Theis, Elizabeth, Panossian, Saarene, Weiss, Helen, Player, Jon, Wilcox, Homer, Vanasse, Louise, Busam, Klaus, Dwyer, Terence, From, Lynn, Ritchey, Mary E., Canchola, Rebecca, Tse, Chiu Kit, Roy, Pampa, Paine, Susan, Jeter, Joanne, Leighton, Nancy, Rosso, Stefano, Armstrong, Bruce K., Clas, Brian, Mujumdar, Urvi, Zanetti, Roberto, Millikan, Robert C., Northrup, David, Mattingly, Dianne, Klotz, Judith, Walker, Amy, Gallagher, Richard P., and Mitra, Nandita
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Epidemiology ,Population ,Skin Pigmentation ,Article ,Ciencias Biológicas ,Biología Celular, Microbiología ,medicine ,Odds Ratio ,Humans ,Solar Elastosis ,education ,Ultraviolet radiation ,Melanoma ,Sunlight ,education.field_of_study ,integumentary system ,business.industry ,Uv Exposure ,Age Factors ,food and beverages ,Odds ratio ,Middle Aged ,medicine.disease ,Elastic Tissue ,Dermatology ,Confidence interval ,Phenotype ,Oncology ,biological sciences ,Female ,Sun exposure ,business ,CIENCIAS NATURALES Y EXACTAS - Abstract
Background: Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored. Methods: The study included 2,589 incident primary melanoma patients with assessment of histologic solar elastosis in the population-based Genes, Environment, and Melanoma study. Ambient erythemal UV (UVE) at places of residence and sun exposure hours, including body site-specific exposure, were collected. We examined the association of cumulative site-specific and non-site-specific sun exposure hours and ambient UVE with solar elastosis in multivariable models adjusted for age, sex, center, pigmentary characteristics, nevi, and, where relevant, body site. Results: Solar elastosis was associated most strongly with site-specific UVE [odds ratio (OR) for top exposure quartile, 5.20; 95% confidence interval (95% CI), 3.40-7.96; P for trend 70 years, 7.69; 95% CI, 5.14-11.52; P for trend < 0.001) and having more than 10 back nevi (OR, 0.77; 95% CI, 0.61-0.97; P = 0.03) were independently associated with solar elastosis. Conclusion: Solar elastosis had a strong association with higher site-specific UVE dose, older age, and fewer nevi. Impact: Solar elastosis could be a useful biomarker of lifetime site-specific UV. Future research is needed to explore whether age represents more than simple accumulation of sun exposure and to determine why people with more nevi may be less prone to solar elastosis. Fil: Thomas, Nancy E.. Fil: Kricker, Anne. Fil: From, Lynn. Fil: Busam, Klaus. Fil: Millikan, Robert C.. Fil: Ritchey, Mary E.. Fil: Armstrong, Bruce K.. Fil: Lee-Taylor, Julia. Fil: Marrett, Loraine D.. Fil: Anton-Culver, Hoda. Fil: Zanetti, Roberto. Fil: Rosso, Stefano. Fil: Gallagher, Richard P.. Fil: Dwyer, Terence. Fil: Goumas, Chris. Fil: Kanetsky, Peter A.. Fil: Begg, Colin B.. Fil: Orlow, Irene. Fil: Wilcox, Homer. Fil: Paine, Susan. Fil: Berwick, Marianne. Fil: Mujumdar, Urvi. Fil: Hummer, Amanda J.. Fil: Mitra, Nandita. Fil: Roy, Pampa. Fil: Canchola, Rebecca. Fil: Clas, Brian. Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Monroe, Yvette. Fil: Litchfield, Melisa. Fil: Tucker, Paul. Fil: Stephens, Nicola. Fil: Switzer, Teresa. Fil: Theis, Elizabeth. Fil: Chowdhury, Noori. Fil: Vanasse, Louise. Fil: Purdue, Mark. Fil: Northrup, David. Fil: Sacerdote, Carlotta. Fil: Leighton, Nancy. Fil: Gildea, Maureen. Fil: Gruber, Stephen B.. Fil: Bonner, Joe. Fil: Jeter, Joanne. Fil: Klotz, Judith. Fil: Weiss, Helen. Fil: Mattingly, Dianne. Fil: Player, Jon. Fil: Tse, Chiu-Kit. Fil: Rebbeck, Timothy R.. Fil: Kanetsky, Peter. Fil: Walker, Amy. Fil: Panossian, Saarene. Fil: Mohrenweiser, Harvey. Fil: Setlow, Richard. Fil: Taylor, Julia Lee. Fil: Madronich, Sasha.
- Published
- 2010
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29. No association between prediagnosis exercise and survival in patients with high-risk primary melanoma: A population-based study.
- Author
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Schwitzer, Emily, Orlow, Irene, Zabor, Emily C., Begg, Colin B., Berwick, Marianne, Thomas, Nancy E., Kanetsky, Peter A., Jones, Lee W., Busam, Klaus J., Reiner, Anne S., Roy, Pampa, Sharma, Ajay, Pilla, Emily La, Luo, Li, White, Kirsten, Paine, Susan, Armstrong, Bruce K., Kricker, Anne, Cust, Anne E., and Venn, Alison
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MELANOMA ,NONFICTION - Published
- 2017
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30. Tecnicas e ferramentas para a extração inteligente e automatica de conhecimento em banco de dados
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Newton Roy Pampa Quispe, Baranauskas, Vitor, 1952-2014, Universidade Estadual de Campinas. Faculdade de Engenharia Elétrica e de Computação, and UNIVERSIDADE ESTADUAL DE CAMPINAS
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Garimpagem de dados ,Banco de dados - Abstract
Orientador: Vitor Baranauskas Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação Mestrado
- Published
- 2003
31. Associations of MC1RGenotype and Patient Phenotypes with BRAFand NRASMutations in Melanoma
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Thomas, Nancy E., Edmiston, Sharon N., Kanetsky, Peter A., Busam, Klaus J., Kricker, Anne, Armstrong, Bruce K., Cust, Anne E., Anton-Culver, Hoda, Gruber, Stephen B., Luo, Li, Orlow, Irene, Reiner, Anne S., Gallagher, Richard P., Zanetti, Roberto, Rosso, Stefano, Sacchetto, Lidia, Dwyer, Terence, Parrish, Eloise A., Hao, Honglin, Gibbs, David C., Frank, Jill S., Ollila, David W., Begg, Colin B., Berwick, Marianne, Conway, Kathleen, Berwick, Marianne, Begg, Colin B., Orlow, Irene, Busam, Klaus J., Reiner, Anne S., Roy, Pampa, Patel, Himali, Berwick, Marianne, Luo, Li, Paine, Susan, Cust, Anne E., Armstrong, Bruce K., Kricker, Anne, Venn, Alison, Dwyer, Terence, Tucker, Paul, Gallagher, Richard P., Marrett, Loraine D., From, Lynn, Zanetti, Roberto, Rosso, Stefano, Anton-Culver, Hoda, Gruber, Stephen B., Huang, Shu-Chen, Thomas, Nancy E., Ollila, David W., Conway, Kathleen, Groben, Pamela A., Edmiston, Sharon N., Hao, Honglin, Parrish, Eloise, Frank, Jill S., Gibbs, David C., Bramson, Jennifer I., Rebbeck, Timothy R., Kanetsky, Peter A., Lee Taylor, Julia, and Madronich, Sasha
- Abstract
Associations of MC1Rwith BRAFmutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1Rand phenotypes were associated with melanoma BRAF/NRASsubtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF+were associated with younger age, blond/light brown hair, increased nevi, and less freckling, and NRAS+with older age relative to the wild type (BRAF–/NRAS–) melanomas (all P< 0.05). Comparing specific BRAFsubtypes to the wild type, BRAFV600E was associated with younger age, blond/light brown hair, and increased nevi and V600K with increased nevi and less freckling (all P< 0.05). MC1Rwas positively associated with BRAFV600E cases but only among individuals with darker phototypes or darker hair (Pinteraction< 0.05) but inversely associated with BRAFV600K (Ptrend = 0.006) with no significant effect modification by phenotypes. These results support distinct etiologies for BRAFV600E, BRAFV600K, NRAS+, and wild-type melanomas. MC1R’s associations with BRAFV600E cases limited to individuals with darker phenotypes indicate that MC1Rgenotypes specifically provide information about BRAFV600E melanoma risk in those not considered high risk based on phenotype. Our results also suggest that melanin pathways deserve further study in BRAFV600E melanomagenesis.
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- 2017
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32. MATERNAL BMI- HOW IT AFFECT OBSTETRIC BEHAVIOUR AND PREGNANCY OUTCOME
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Saha, Dhrubajyati, primary, Roy, Pampa, additional, Koley, Arnab Kumar, additional, Saha, Apurba, additional, Dey, Babul Chandra, additional, Ari, Madhumoy, additional, Ganguly, Tapan Kumar, additional, and Mukhopadhyaya, Asish Kumar, additional
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- 2013
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33. SERUM LIPID PROFILE- HOW IT ALTERS IN NORMOTENSIVE AND HYPERTENSIVE PREGNANT WOMEN
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Saha, Dhrubajyati, primary, Roy, Pampa, additional, Pal, Rajib, additional, Ganguli, Tapan Kumar, additional, Maity, Santu, additional, Rakshit, Bibek Mohan, additional, Sengupta, Prabir, additional, and Halder, Sanjana, additional
- Published
- 2013
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34. Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a populationbased study.
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Orlow, Irene, Reiner, Anne S., Thomas, Nancy E., Roy, Pampa, Kanetsky, Peter A., Luo, Li, Paine, Susan, Armstrong, Bruce K., Kricker, Anne, Marrett, Loraine D., Rosso, Stefano, Zanetti, Roberto, Gruber, Stephen B., Anton-Culver, Hoda, Gallagher, Richard P., Dwyer, Terence, Busam, Klaus, Begg, Colin B., and Berwick, Marianne
- Subjects
VITAMIN D receptors ,GENETIC polymorphisms ,MELANOMA ,RENAL cell carcinoma ,DISEASE incidence - Abstract
Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values < 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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35. Vitamin D Receptor Gene Haplotypes and Polymorphisms and Risk of Breast Cancer: A Nested Case–Control Study
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Engel, Lawrence S., primary, Orlow, Irene, additional, Sima, Camelia S., additional, Satagopan, Jaya, additional, Mujumdar, Urvi, additional, Roy, Pampa, additional, Yoo, Sarah, additional, Sandler, Dale P., additional, and Alavanja, Michael C., additional
- Published
- 2012
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36. Investigation of the Effect of MDM2 SNP309 and TP53 Arg72Pro Polymorphisms on the Age of Onset of Cutaneous Melanoma
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Cotignola, Javier, primary, Chou, Joanne F., additional, Roy, Pampa, additional, Mitra, Nandita, additional, Busam, Klaus, additional, Halpern, Allan C., additional, and Orlow, Irene, additional
- Published
- 2012
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37. Allergenicity Assessment of Allium sativum Leaf Agglutinin, a Potential Candidate Protein for Developing Sap Sucking Insect Resistant Food Crops
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Mondal, Hossain Ali, primary, Chakraborti, Dipankar, additional, Majumder, Pralay, additional, Roy, Pampa, additional, Roy, Amit, additional, Bhattacharya, Swati Gupta, additional, and Das, Sampa, additional
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- 2011
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38. Tecnicas e ferramentas para a extração inteligente e automatica de conhecimento em banco de dados
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Roy Pampa Quispe, Newton, primary
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39. Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression
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Cotignola, Javier, primary, Roy, Pampa, additional, Patel, Ami, additional, Ishill, Nicole, additional, Shah, Shivang, additional, Houghton, Alan, additional, Coit, Daniel, additional, Halpern, Allan, additional, Busam, Klaus, additional, Berwick, Marianne, additional, and Orlow, Irene, additional
- Published
- 2007
- Full Text
- View/download PDF
40. Allergies, variants in IL-4 and IL-4Rα genes, and risk of pancreatic cancer
- Author
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Olson, Sara H., primary, Orlow, Irene, additional, Simon, Jennifer, additional, Tommasi, Diana, additional, Roy, Pampa, additional, Bayuga, Sharon, additional, Ludwig, Emmy, additional, Zauber, Ann G., additional, and Kurtz, Robert C., additional
- Published
- 2007
- Full Text
- View/download PDF
41. Recombinant Glutathione S-Transferase/CD36 Fusion Proteins Define an Oxidized Low Density Lipoprotein-binding Domain
- Author
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Pearce, S. Frieda A., primary, Roy, Pampa, additional, Nicholson, Andrew C., additional, Hajjar, David P., additional, Febbraio, Maria, additional, and Silverstein, Roy L., additional
- Published
- 1998
- Full Text
- View/download PDF
42. BCL6 Gene Rearrangement and Other Cytogenetic Abnormalities in Diffuse Large Cell Lymphoma
- Author
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Offit, Kenneth, primary, Louie, Diane C., additional, Parsa, Nasser Z., additional, Roy, Pampa, additional, Leung, Denis, additional, Coco, Francesco Lo, additional, Zelenetz, Andrew, additional, Dalla-Favera, Riccardo, additional, and Chaganti, R. S. K., additional
- Published
- 1995
- Full Text
- View/download PDF
43. Allergenicity Assessment of Allium sativum Leaf Agglutinin, a Potential Candidate Protein for Developing Sap Sucking Insect Resistant Food Crops.
- Author
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Ali Mondal, Hossain, Chakraborti, Dipankar, Majumder, Pralay, Roy, Pampa, Roy, Amit, Bhattacharya, Swati Gupta, and Das, Sampa
- Subjects
GARLIC ,AGGLUTININS ,PLANT resistance to insects ,FOOD crops ,PROTEINS ,ENZYME-linked immunosorbent assay ,BLOOD - Abstract
Background: Mannose-binding Allium sativum leaf agglutinin (ASAL) is highly antinutritional and toxic to various phloemfeeding hemipteran insects. ASAL has been expressed in a number of agriculturally important crops to develop resistance against those insects. Awareness of the safety aspect of ASAL is absolutely essential for developing ASAL transgenic plants. Methodology/Principal Findings: Following the guidelines framed by the Food and Agriculture Organization/World Health Organization, the source of the gene, its sequence homology with potent allergens, clinical tests on mammalian systems, and the pepsin resistance and thermostability of the protein were considered to address the issue. No significant homology to the ASAL sequence was detected when compared to known allergenic proteins. The ELISA of blood sera collected from known allergy patients also failed to show significant evidence of cross-reactivity. In vitro and in vivo assays both indicated the digestibility of ASAL in the presence of pepsin in a minimum time period. Conclusions/Significance: With these experiments, we concluded that ASAL does not possess any apparent features of an allergen. This is the first report regarding the monitoring of the allergenicity of any mannose-binding monocot lectin having insecticidal efficacy against hemipteran insects. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
44. Isolation of Thiobacillus ferrooxidans from various habitats and their growth pattern on solid medium.
- Author
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Mishra, Ajit, Roy, Pampa, and Mahapatra, S.
- Abstract
Different strains of iron-oxidizing Thiobacillus ferrooxidans were grown and purified on solid medium containing Bapco agar, agarose, and carrageenan (Type 1). These strains produced easily countable isolated colonies that could be transferred after 7 days of incubation at 30°C. Increase in viable cell number in relation to growth and iron oxidation was studied by both microscopic count and direct plating method. Colony morphology of different strains growing on solid medium helped in differentiating the colony types. [ABSTRACT FROM AUTHOR]
- Published
- 1983
- Full Text
- View/download PDF
45. Validation of Denaturing High Performance Liquid Chromatography as a Rapid Detection Method for the Identification of Human INK4AGene Mutations
- Author
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Orlow, Irene, Roy, Pampa, Barz, Allison, Canchola, Rebecca, Song, Yan, and Berwick, Marianne
- Abstract
The incidence of melanoma is increasing rapidly in western countries. Genetic predisposition in familial and in some sporadic melanomas has been associated with the presence of INK4Agene mutations. To better define the risk for developing sporadic melanoma based on genetic and environmental interactions, large groups of cases need to be studied. Mutational analysis of genes lacking hot spots for sequence variations is time consuming and expensive. In this study we present the application of denaturing high performance liquid chromatography (DHPLC) for screening of mutations. Exons 1α, 2, and 3 were amplified from 129 samples and 13 known mutants, yielding 347 products that were examined at different temperatures. Forty-two of these amplicons showed a distinct non-wild-type profile on the chromatogram. Independent sequencing analysis confirmed 16 different nucleotide variations in Leu32Pro; Ile49Thr; 88 del G; Gln50Arg; Arg24Pro; Met53Ile; Met53Thr; Arg58stop; Pro81Leu; Asp84Ala; Arg80stop; Gly101Trp; Val106Val; Ala148Thr; and in positions (−2) in intron 1 (C → T); and in the 3′ UTR, nucleotide 500 (C → G). No false negatives or false positives were obtained by DHPLC in samples with mutations or polymorphisms. We conclude that the DHPLC is a fast, sensitive, cost-efficient, and reliable method for the scanning of INK4Asomatic or germline mutations and polymorphisms of large number of samples.
- Published
- 2001
- Full Text
- View/download PDF
46. Sun Exposure, Vitamin D Receptor Genetic Variants, and Risk of Breast Cancer in the Agricultural Health Study
- Author
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Mujumdar, Urvi, Roy, Pampa, Yoo, Sarah, Coble, Joseph, Satagopan, Jaya, Alavanja, Michael C., Engel, Lawrence S., Sima, Camelia S., Sandler, Dale P., and Orlow, Irene
- Subjects
2. Zero hunger ,integumentary system ,sense organs ,skin and connective tissue diseases ,eye diseases ,3. Good health - Abstract
Background: Epidemiologic evidence suggests a negative relation between sunlight exposure and breast cancer risk. The hypothesized mechanism is sunlight-induced cutaneous synthesis of vitamin D.
47. CDKN2A Germline Mutations in Individuals with Cutaneous Malignant Melanoma
- Author
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Canchola, Rebecca, Gruber, Stephen, Clas, Brian, Dwyer, Terence, Kanetsky, Peter, Zanetti, Roberto, Mujumdar, Urvi, Roy, Pampa, Orlow, Irene, Berwick, Marianne, Busam, Klaus, Begg, Colin, Cotignola, Javier, Millikan, Robert, Hummer, Amanda, Anton-Culver, Hoda, Rebbeck, Timothy, From, Lynn, Armstrong, Bruce, Wilcox, Homer, Marrett, Loraine, GEM Study Group, Kricker, Anne, and Gallagher, Richard
- Subjects
neoplasms ,3. Good health - Abstract
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptibility gene based on the presence of germline mutations in high-risk melanoma families. In this study, we sought to identify and characterize the spectrum of CDKN2A mutations affecting p16 inhibitor of cyclin-dependent kinase type 4 (INK4a) in individuals with melanoma using a population-based study design. DNA samples from 1189 individuals with incident multiple primary melanoma (MPM) and 2424 with incident single primary melanoma unselected for family history of melanoma were available for screening of CDKN2A (p16INK4a) mutations. Variants were classified for functional impact based on intragenic position, existing functional data, sequence, and structural analysis. The impact of individual mutations and functional groupings was assessed by comparing frequencies in cases of MPM versus cases with a single first primary melanoma, and by comparing the reported incidence rates in first-degree relatives. Our results show that mutations occur infrequently in these high-risk groups, and that they occur mainly in exons 1alpha and 2. Rare coding variants with putative functional impact are observed to increase substantially the risk of melanoma. With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk.
48. Multiple forms of atrial natriuretic factor receptor in human placenta
- Author
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Roy, Pampa, primary, Naik, Ulhas, additional, and Sen, Indira, additional
- Published
- 1988
- Full Text
- View/download PDF
49. Atrial natriuretic factor induced phosphorylation of human placental membrane protein: An effect mimicked by guanosine 3′: 5′-cyclic monophosphate
- Author
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Sen, Indira, primary and Roy, Pampa, additional
- Published
- 1986
- Full Text
- View/download PDF
50. Deoxyribonucleic Acid-Mediated Transformation of Spirillum lipoferum
- Author
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Mishra, Ajit K., primary, Roy, Pampa, additional, and Bhattacharya, Sabita, additional
- Published
- 1979
- Full Text
- View/download PDF
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