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MC1Rvariants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Authors :
Pellegrini, Cristina
Botta, Francesca
Massi, Daniela
Martorelli, Claudia
Facchetti, Fabio
Gandini, Sara
Maisonneuve, Patrick
Avril, Marie-Françoise
Demenais, Florence
Bressac-de Paillerets, Brigitte
Hoiom, Veronica
Cust, Anne E
Anton-Culver, Hoda
Gruber, Stephen B
Gallagher, Richard P
Marrett, Loraine
Zanetti, Roberto
Dwyer, Terence
Thomas, Nancy E
Begg, Colin B
Berwick, Marianne
Puig, Susana
Potrony, Miriam
Nagore, Eduardo
Ghiorzo, Paola
Menin, Chiara
Manganoni, Ausilia Maria
Rodolfo, Monica
Brugnara, Sonia
Passoni, Emanuela
Sekulovic, Lidija Kandolf
Baldini, Federica
Guida, Gabriella
Stratigos, Alexandros
Ozdemir, Fezal
Ayala, Fabrizio
Fernandez-de-Misa, Ricardo
Quaglino, Pietro
Ribas, Gloria
Romanini, Antonella
Migliano, Emilia
Stanganelli, Ignazio
Kanetsky, Peter A
Pizzichetta, Maria Antonietta
García-Borrón, Jose Carlos
Nan, Hongmei
Landi, Maria Teresa
Little, Julian
Newton-Bishop, Julia
Sera, Francesco
Fargnoli, Maria Concetta
Raimondi, Sara
Alaibac, Mauro
Ferrari, Andrea
Valeri, Barbara
Sicher, Mariacristina
Mangiola, Daniela
Nazzaro, Gianluca
Tosti, Giulio
Mazzarol, Giovanni
Giudice, Giuseppe
Ribero, Simone
Astrua, Chiara
Romanini, Antonella
Mazzoni, Laura
Orlow, Irene
Mujumdar, Urvi
Hummer, Amanda
Busam, Klaus
Roy, Pampa
Canchola, Rebecca
Clas, Brian
Cotignola, Javiar
Monroe, Yvette
Armstrong, Bruce
Kricker, Anne
Litchfield, Melisa
Tucker, Paul
Stephens, Nicola
Switzer, Teresa
Theis, Beth
From, Lynn
Chowdhury, Noori
Vanasse, Louise
Purdue, Mark
Northrup, David
Rosso, Stefano
Sacerdote, Carlotta
Leighton, Nancy
Gildea, Maureen
Bonner, Joe
Jeter, Joanne
Klotz, Judith
Wilcox, Homer
Weiss, Helen
Millikan, Robert
Mattingly, Dianne
Player, Jon
Tse, Chiu-Kit
Rebbeck, Timothy
Walker, Amy
Panossian, Saarene
Setlow, Richard
Mohrenweiser, Harvey
Autier, Philippe
Han, Jiali
Caini, Saverio
Hofman, Albert
Kayser, Manfred
Liu, Fan
Nijsten, Tamar
Uitterlinden, Andre G.
Kumar, Rajiv
Bishop, Tim
Elliott, Faye
Lazovich, DeAnn
Polsky, David
Hansson, Johan
Pastorino, Lorenza
Gruis, Nelleke A.
Bouwes Bavinck, Jan Nico
Aguilera, Paula
Badenas, Celia
Carrera, Cristina
Gimenez-Xavier, Pol
Malvehy, Josep
Puig-Butille, Joan Anton
Tell-Marti, Gemma
Blizzard, Leigh
Cochrane, Jennifer
Branicki, Wojciech
Debniak, Tadeusz
Morling, Niels
Johansen, Peter
Mayne, Susan
Bale, Allen
Cartmel, Brenda
Ferrucci, Leah
Pfeiffer, Ruth
Palmieri, Giuseppe
Kypreou, Katerina
Bowcock, Anne
Cornelius, Lynn
Council, M. Laurin
Motokawa, Tomonori
Anno, Sumiko
Helsing, Per
Andresen, Per Arne
Guida, Stefania
Wong, Terence H.
Source :
The Lancet Child & Adolescent Health; May 2019, Vol. 3 Issue: 5 p332-342, 11p
Publication Year :
2019

Abstract

Germline variants in the melanocortin 1 receptor gene (MC1R)might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1Rvariants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1Rvariants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Details

Language :
English
ISSN :
23524642 and 23524650
Volume :
3
Issue :
5
Database :
Supplemental Index
Journal :
The Lancet Child & Adolescent Health
Publication Type :
Periodical
Accession number :
ejs49174731
Full Text :
https://doi.org/10.1016/S2352-4642(19)30005-7