Search

A study conducted at Normandie University in France focused on assessing the rates of pathogenic variants in Mendelian dementia genes and risk factors in patients with Alzheimer's disease. The study included 700 patients and found that 21 patients carried pathogenic variants in Mendelian genes, while 69.5% of the remaining patients had risk factors. The researchers recommend genetic screening for all early-onset Alzheimer's disease patients, regardless of pedigree structure. The study was published in Genetics in Medicine and was supported by Fondation Alzheimer and Agence Nationale de la Recherche. [Extracted from the article]

A recent study conducted by the University of Rouen Normandie analyzed scientific literature from 1970 to 2023 to explore the evolving paradigms within menstrual health. The research revealed three distinct periods in menstrual health research, highlighting shifts in focus from reproductive health to social inequalities and psychological dimensions. The study emphasized the importance of a balanced, holistic understanding of menstrual health and the need for tailored interventions that respect diverse cultural and psychological realities related to menstruation. Continued efforts are necessary to promote inclusivity and address the complexities of menstrual health. [Extracted from the article]

Researchers at Rouen University Hospital in France conducted a study on pancreatic adenocarcinoma (PA) to assess the prognostic value of baseline carbohydrate antigen 19.9 (CA19-9) and circulating tumor DNA (ctDNA) for overall survival. The study found that combining ctDNA with CA19-9 could help define biological borderline situations in PA, aiding in risk stratification and treatment decisions. This research, supported by the French Ministry of Health and Institut National du Cancer (INCA) France, provides valuable insights for improving the management of pancreatic cancer. [Extracted from the article]

A study conducted at the University Hospital in Rouen, France, evaluated a newly developed HIV immunoassay called Access HIV Ag/Ab combo. The assay demonstrated high clinical sensitivity and specificity, accurately detecting both chronic and primary HIV infections. It was compared to two gold standard assays and showed better results in early detection and viral lysates. The study concluded that the Access HIV Ag/Ab combo assay is effective in diagnosing HIV infections, despite the genetic diversity of the virus. [Extracted from the article]

A recent study conducted by the University of Rouen Normandie in France examined the incidence and risk factors for thromboembolic events (TE) in pediatric-onset inflammatory bowel disease (IBD). The study followed 1,344 patients diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. The researchers found that patients with IBD had a low risk of TE, but periods of active disease, surgery, and hospitalization were associated with an increased risk of venous thromboembolism (VTE). The study also found that patients treated with 5-aminosalicylates had a lower rate of VTE. This research provides valuable information for guiding thromboprophylaxis in pediatric-onset IBD. [Extracted from the article]

A recent study conducted by Normandie University in Rouen, France, examined the recognition and compensation of occupational diseases (OD) related to asbestos exposure. The study analyzed data from the French multicenter Asbestos-Related Disease Cohort (ARDCO) and found that 15% of the participants had at least one recognized asbestos-related OD, including benign pleural disease, asbestosis, lung cancer, and mesothelioma. However, the study also revealed that not all cases of OD were recognized, indicating a need for better training of medical professionals involved in the recognition process. The study highlights the feasibility of a system to facilitate recognition and compensation for asbestos-related occupational diseases. [Extracted from the article]

A recent study conducted at Normandie University in Rouen, France, explored the impact of rituximab (RTX) treatment on the circulating subpopulations of T lymphocytes in patients with pemphigus vulgaris (PV), an autoimmune disease characterized by autoantibodies targeting keratinocyte adhesion proteins. The researchers found that RTX treatment led to a decrease in autoreactive T follicular helper (Tfh) cells and an emergence of autoreactive T follicular regulatory (Tfr) cells, which were more activated compared to other T cells. These findings suggest that the emergence of Tfr cells may be responsible for the long-term efficacy of RTX in achieving sustained remission in some PV patients. [Extracted from the article]

A report from the Polytechnic Institute of UniLaSalle in France discusses the findings of research on governance structures and stakeholder involvement in urban agricultural projects. The research focuses on four case studies in France, two in Paris and two in Rouen, with different goals and priorities. The study found that while there are similarities in administrative structures, there are also differences in terms of management and priorities. Three of the initiatives aim to engage with local residents and prioritize social and educational inclusion, while one has a stronger focus on business and commerce. The research highlights the importance of urban agriculture in addressing food security and improving quality of life in cities. [Extracted from the article]

A study conducted at Rouen University Hospital in France compared the effectiveness of a titanium vertebral augmentation device called the SpineJack system with nonsurgical management (NSM) using bracing for the treatment of vertebral compression fractures. The study included 100 patients with acute traumatic vertebral fractures who were randomized to receive either the SpineJack system or NSM. The primary outcomes measured were back pain scores, and secondary outcomes included disability, health-related quality of life, radiological measures, and economic outcomes. The study found that both treatment methods resulted in significant improvements in back pain, disability, and quality of life. The SpineJack group showed better radiological outcomes, shorter hospital stays, faster return to work, and fewer hours of nursing care compared to the NSM group. However, there were no significant differences in complications between the two treatments. Overall, the study concluded that the SpineJack system was associated with better radiological outcomes and certain advantages in terms of hospital stay and return to work. [Extracted from the article]

Researchers from University Hospital in Rouen, France have conducted a study on the role of endoscopy in the management of peripheral pulmonary nodules. The study highlights the challenges involved in treating these nodules and emphasizes the importance of specialized skills and advanced technologies. The researchers discuss how advanced endoscopy techniques can aid in the diagnosis and treatment of these nodules, including preoperative marking and fiduciary marker placement for stereotactic radiotherapy treatment. The study also suggests that these techniques may help implement an ablation strategy in the future. The research has been peer-reviewed and published in the Revue des Maladies Respiratoires journal. [Extracted from the article]

Researchers from Normandie University in Rouen, France have conducted a study to evaluate the neuroprotective potential of the leaves of the medicinal plant Sterculia setigera. In vitro experiments showed that the hydroethanolic extract of the leaves protected cerebellar granule neurons against cell death induced by hydrogen peroxide and 6-hydroxydopamine. In vivo experiments on rats exposed to ethanol neurotoxicity demonstrated that the extract reduced caspase-3 activity, inhibited the expression of certain genes, prevented the reduction of the thickness of the cerebellar cortex, and restored motor functions. The researchers concluded that Sterculia setigera could be a promising candidate for the development of a neuroprotective treatment for neurodegenerative diseases. [Extracted from the article]

A study conducted by the University of Rouen Normandie in France investigated the effects of biofeedback-based training on stress management in prepubescent elite female gymnasts. The study found that the training program significantly improved the gymnasts' self-regulatory skills in managing physiological parameters such as peripheral temperature and blood volume pressure. Additionally, the gymnasts showed increased interoceptive awareness and resilience under stressful conditions. The findings suggest that effective stress management strategies can enhance performance, reduce the risk of injuries, and promote overall well-being in young female athletes. [Extracted from the article]

A recent study conducted by the University of Rouen Normandie in France explores the role of nerve tissue proteins in the development of obesity and type 2 diabetes. The researchers focus on the neuropeptide 26RFa and its receptor GPR103, which are involved in the regulation of energy and glucose metabolism. The study suggests that dysfunction in these neural networks may contribute to the development of obesity and diabetes. The researchers emphasize the importance of further understanding these mechanisms in order to develop new therapeutic strategies. [Extracted from the article]

A report from the University of Rouen Normandie in France discusses new research findings on antiinfectives, specifically focusing on the drug praziquantel (PZQ) used to treat schistosomiasis. The researchers explore the possibility of controlling the solid properties of chiral active pharmaceutical ingredients (APIs) through cocrystallization with a coformer, in this case, vanillic acid (VA). They identify two different cocrystal forms of PZQ and VA, one characterized as an equimolar racemic cocrystal and the other as a 1:2 (+)/(-)PZQ:2VA cocrystal that crystallizes as a conglomerate. The study highlights the importance of testing different stoichiometries in cocrystal screening. [Extracted from the article]

A recent study conducted at Normandie University in Rouen, France, has identified potential multitarget ligands for the treatment of Alzheimer's disease. The researchers developed a series of compounds that showed potent inhibition of the enzyme eqBuChE, as well as inhibitory properties against hDYRK1A and hCLK1 kinases. The study found that structural modifications to the compounds led to selective and potent inhibitors. The researchers believe that these compounds have promising potential as drug candidates for the treatment of Alzheimer's disease. [Extracted from the article]

Researchers from Normandy University conducted a study to compare the complications of diabetes and geriatric alterations in older patients with type 2 diabetes based on their prescribed therapeutic modalities over a period of 5 years. The study included 616 patients divided into three groups: an insulin-only group, a group receiving insulin and oral antidiabetic drugs, and an oral antidiabetic drug group without insulin. The study found that there were significant differences in glycosylated hemoglobin values and the frequencies of diabetic complications and geriatric alterations among the three groups. The study also noted higher frequencies of new clinical events in the insulin group, and increased mortality in the insulin group compared to the oral antidiabetic drug group. The researchers suggest that their findings could inform future studies on antidiabetic drugs with cardiovascular action in older patients with type 2 diabetes. [Extracted from the article]

A study conducted at University Hospital Rouen in France investigated the practices of French university hospitals regarding the selection of dosing delivery devices for compounding oral liquid forms for pediatric patients. The study found that there was diversity in the practices, with only one pharmacy using child-resistant caps for compounded liquid forms. Enteral syringes were the primary dosing device, and bottle adapters were commonly used. The researchers concluded that standardized guidelines are needed to improve safety and precision in administering compounded medications to children. This research has been peer-reviewed. [Extracted from the article]

Iron deficiency is a common cause of anemia worldwide, affecting approximately 600 million individuals. It typically presents as a hypochromic microcytic anemia, but can also be associated with thrombocytosis. However, the presence of associated thrombocytopenia is rare. Researchers from University Hospital in Rouen, France, reported a case of severe iron deficiency with an atypical presentation of bicytopenia, involving both severe anemia and profound thrombocytopenia, which rapidly resolved following iron supplementation. The study discusses the hypotheses that exist to explain the link between iron deficiency and regulation of thrombopoiesis. [Extracted from the article]

A new study from University Hospital in Rouen, France, explores the case of a two-year-old child with acute hemolytic anemia. The child was found to have multiple red blood cell abnormalities, including a G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S, all in the context of a primary infection with Parvovirus B19. The researchers emphasize the importance of considering this virus as a potential trigger for acute anemia in children with constitutional red blood cell abnormalities, particularly those of African origin. The study has been peer-reviewed and published in the Annales de biologie clinique. [Extracted from the article]

A study conducted at Rouen University Hospital in France explores the role of aminochrome in the vulnerability of dopaminergic neurons in Parkinson's disease (PD). Aminochrome, a byproduct of dopamine metabolism, is believed to contribute to the oxidative stress and cell death associated with PD. The study suggests that aminochrome may serve as a preclinical model for PD, aiding in the development of therapeutic strategies to slow or prevent disease progression. The research has been peer-reviewed and provides valuable insights into the pathophysiology of PD. [Extracted from the article]

Researchers at Centre Henri Becquerel in Rouen, France have published a report on the effectiveness of stereotactic body radiation therapy for the local management of bone oligometastases. Oligometastases are defined as having at most five metastases, and this therapy has shown benefits in terms of survival and local control. The study focuses on bone oligometastases, which are a common site for secondary cancer locations, and reviews the results of major studies in this field. This research has been peer-reviewed and can be found in the journal Cancer/Radiotherapie. [Extracted from the article]

A recent study conducted by the University of Rouen Normandie in France has found that intrarectal injections of botulinum toxin type A (BoNTA) are an effective treatment for urge fecal incontinence. The study involved 200 adult patients who had experienced at least one episode of urgency or fecal incontinence per week for at least three months. The patients were randomly assigned to receive either BoNTA injections or a placebo, and the primary endpoint was the number of episodes of fecal incontinence and urgency per day. The study found that the BoNTA group experienced a significant decrease in episodes compared to the placebo group. The researchers concluded that further research is needed to determine the optimal criteria, dose, site of injection, re-injection frequency, and long-term results. [Extracted from the article]

A survey conducted with French Obstetrics and Gynecology residency program directors found that simulation training is widely available in these programs. The survey covered equipment, human resources, training programs, and types of simulation tools. The results showed that all respondents had at least one structure dedicated to simulation, and a formal training program was reported by 81% of cities. However, there was heterogeneity between centers regarding equipment, time spent, and content of simulation curricula. The French College of Teachers of Gynecology and Obstetrics has proposed a roadmap for the content of simulation-based training based on the survey results. [Extracted from the article]

Researchers from Normandie University in Rouen, France have conducted a study on the replicative potential of HIV-1/MO intergroup recombinant viruses compared to the parental viruses HIV-1/M and HIV-1/O. The study found that the group M parental virus showed superiority over the group O parental virus in terms of replicative potential. However, the recombinant virus exhibited a hybrid behavior, with differences in enzyme activity and P24 production. These findings highlight the impact of recombination on the replicative potential of HIV and demonstrate the flexibility and evolutionary possibilities of HIV genomes. [Extracted from the article]

A recent study conducted by the University of Rouen Normandie in France has translated the Nine Item Avoidant/Restrictive Food Intake Disorder (ARFID) Screen (NIAS) questionnaire into French. The translation process involved multiple steps, including testing the translated version on patients and making corrections based on their feedback. The final version, known as the NIAS-Fr, was approved for use in 54 French-speaking countries, serving approximately 321 million French speakers across five continents. This questionnaire will be valuable for screening ARFID in both clinical and research settings. [Extracted from the article]

A recent study conducted by Normandie University in Rouen, France, examined feeding and eating disorders (FED) in 191 children. The study aimed to investigate the clinical features of FED and compare them based on recruitment into either the gastroenterology or psychiatry unit. The main findings revealed that children with FED often had somatic and psychiatric comorbidities, emphasizing the need for a multidisciplinary approach to assessment and care. The study highlights the importance of understanding and addressing the complex nature of FED in children. [Extracted from the article]

New research from the University of Rouen Normandie in France explores the co-occurrence of two conditions, primary familial brain calcification (PFBC) and Alzheimer's disease (AD). PFBC is a rare disorder that can present with a range of symptoms, while AD is a common condition characterized by progressive cognitive impairment. The study highlights the challenge of accurately diagnosing cognitive impairment when multiple pathologies contribute to the clinical phenotype. The researchers emphasize the importance of thoroughly characterizing patients' symptoms and considering the possibility of rare diseases co-occurring with common ones. [Extracted from the article]

A study conducted by the University of Rouen Normandy in France evaluated the efficacy of sacral neuromodulation (SNM) in treating voiding dysfunction (VD) following endometriosis surgery. The study included 21 patients, and after a median follow-up of 55 months, 60% of patients achieved successful outcomes with significant improvements in VD and quality of life. The study suggests that SNM can be a valuable therapeutic option for patients with persistent VD after endometriosis surgery, although further research is needed to identify predictive factors and mechanisms underlying the effectiveness of SNM in this context. The study has been peer-reviewed and published in Progres En Urologie. [Extracted from the article]

A recent study conducted by researchers at the University of Rouen Normandie in France explores the use of zeolites in tissue engineering. Zeolites are known for their large surface area, stability, and crystalline structure, making them ideal for various applications. In this study, the researchers developed zeolite-based composites by bonding gelatin to zeolites. The composites showed good stability and thermal properties, making them potential candidates for tissue engineering and wound dressing. The research provides valuable insights into the synthesis and characterization of these biocompatible composites. [Extracted from the article]

A recent study conducted at Rouen University Hospital in France has provided new insights into stroke, specifically in young adults. The study focused on a 37-year-old woman who experienced a sudden dysarthria, or difficulty speaking, for less than a minute. Initial brain MRI scans did not show any signs of acute cerebral infarction, but further examination revealed an intraluminal thrombus and hyperintense vessels related to slow flow. A follow-up MRI confirmed the presence of a small infarct, and a comprehensive investigation identified a patent foramen ovale as the underlying cause of the stroke. The researchers concluded that a careful brain MRI examination or the use of perfusion weighted imaging sequences can help avoid misdiagnosis, particularly in young patients. [Extracted from the article]