71 results on '"Rosin L"'
Search Results
2. P506 Rates of clinical remission among patients with Ulcerative Colitis from real-world clinical practice settings from Germany
- Author
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Bokemeyer, B, primary, Picker, N, additional, Kromer, D, additional, Rosin, L, additional, and Patel, H, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Atrial fibrillation and its management by cardiologists in the ambulatory and hospital setting: 1-year non-interventional study (MOVE)
- Author
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Bosch, R.F., Kirch, W., Rosin, L., Willich, S.N., Pittrow, D., and Bonnemeier, H.
- Published
- 2011
4. P404 Healthcare utilization and expenditures for patients with Ulcerative Colitis on advanced therapies in Germany
- Author
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Picker, N, primary, Bokemeyer, B, additional, Wilke, T, additional, Rosin, L, additional, and Patel, H, additional
- Published
- 2021
- Full Text
- View/download PDF
5. P377 Inadequate response with advanced therapies in real-world patients with Ulcerative Colitis – Results of a German claims database study
- Author
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Bokemeyer, B, primary, Picker, N, additional, Wilke, T, additional, Rosin, L, additional, and Patel, H, additional
- Published
- 2021
- Full Text
- View/download PDF
6. P464 Steroid dependency in patients with Ulcerative Colitis treated with advanced therapies in a German real-world-setting
- Author
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Bokemeyer, B, primary, Picker, N, additional, Wilke, T, additional, Rosin, L, additional, and Patel, H, additional
- Published
- 2021
- Full Text
- View/download PDF
7. P423 Treatment escalation and associated cost in German Ulcerative Colitis patients treated with advanced therapies
- Author
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Picker, N, primary, Patel, H, additional, Wilke, T, additional, Rosin, L, additional, and Bokemeyer, B, additional
- Published
- 2021
- Full Text
- View/download PDF
8. Karotisendarteriektomie und Karotisstenting Pilotstudie eines prospektiven, randomisierten und kontrollierten Vergleichs: Pilotstudie eines prospektiven, randomisierten und kontrollierten Vergleichs
- Author
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Link, J., Manke, C., Rosin, L., Borisch, I., Töpel, I., Horn, M., Mann, S., Jauch, K.-W., Bogdahn, U., Feuerbach, St., and Kasprzak, P.
- Published
- 2000
- Full Text
- View/download PDF
9. DETECTION OF UNDIAGNOSED SILENT AF IN PATIENTS WITH ACUTE STROKE: 9
- Author
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Grond, M., Rosin, L., and Kirchhof, P.
- Published
- 2011
10. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. I., Torbergsen, T., Mellgren, S. I., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Boller, F., Bonavita, V., Engelhardt, A., Lörler, H., Robeck, S., Kluglein, C., Comi, G., Avoledo, V., Locatelli, T., Leocani, L., Galardi, G., Magnani, G., Medaglini, S., Chkhikvishvili, T. S., Zangaladze, A., Bratoeva, M., Kovachev, P., Chavdarov, D., Artemis, N., Karacostas, D., Milonas, I., Arpa, J., Lopez-Pajares, R., Cruz-Matinez, A., Sarria, J., Palomo, F., Alonso, M., Rodriguez-Al-barino, A., Lacasa, T., Nos, J., Barreiro, P., Martinez, A. Cruz, Villoslada, C., Alons, M., Taghavy, A., Hamer, H., Kratzer, A., Dethy, S., Pauwels, T., Monclus, M., Luxen, A., Goldman, S., Ziegler, M., Crambes, O., Ragueneau, I., Arnaud, F., Zappia, M., Montesanti, R., Colao, R., Palmieri, A., Branca, D., Nicoletti, G., Rizzo, M., Parlato, G., Quattrone, A., Vanacore, N., Zuchegna, P., Bonifati, V., Meco, G., Scholz, J., Friedrich, H. -J., Rohl, A., Ulm, G., Vieregge, P., Savettieri, G., Rocca, W. A., Meneghini, F., Grigoletto, F., Morgante, L., Reggio, A., Salemi, G., Di Pierri, R., OzckmekÇi, S., Ertan, S., Yeni, N., Apaydin, H., Erkol, G., Kiziltan, G., Denktas, F., Ranoux, D., de Recondo, J., Ostergaard, L., Werdelin, L., Odin, P., Lindvall, O., Dupont, E., Christensen, P. B., Boisen, E., Jensen, N. B., Schmiegelow, M., Ingwersen, S. H., Matias-Guiu, J., Canet, T., Falip, R., Martin, R., Galiano, L., Voloshin, M. Y., Burchinskaya, L. F., Cabrera-Valdivia, F., Jimenez-Jimenez, F. J., Molina, J. A., Fernandez-Calle, P., Vazquez, A., Canizares-Liebana, F., Larumbe-Lobalde, S., Ayuso-Peralta, L., Rabasa, M., Codoceo, R., Arrieta, F. J., Aguilar, M. V., Jorge-Santamaria, A., Martinez-Para, M. C., Alarcon, J., Mateo, D., Gimenez-Roldan, S., Gencheva, E., Tzonev, T. z., Georgiev, G., Petkova, P., Gasparini, M., Vanacore, N., Meco, N. G., de la Sierra, G., Aguado, F., Revilla, M., Varela, L., Rico, H., Feve, A., N'Guyen, J. P., Bathien, N., Fenelon, G., Veroust, J., Cesaro, P., Egersbach, G., Hattig, H., Schelosky, L., Wissel, J., Poewe, W., Durif, F., Albuisson, E., Debilly, B., Tournilhac, M., Magnani, C., Mocellini, C., Soffietti, R., Schiffer, D., Cardozo, A., Cruz-Sanchez, F. F., Falip, L., Potagas, G., Ziegler, M., Rondot, P., Bonifati, V., Fabrizio, E., Meco, G., Bostantjopoulou, S., Katsarou, Z., Kyriazis, G., Baas, H., Demisch, L., Esser, A., Zoeller, F., Burklin, F., Harder, S., Fischer, P. A., Arcusa, M. J., Hermandez, S., Claramonte, F. J., Pascual, A. Pascual- Leone, Alonso, M. D., Catata, M. D., Alessandri, A., Giustini, P., Dufour, A., Ciusani, E., Nespolo, A., Roelcke U., Radu E. W., von Ammon K., Maguire R. P., Leenders K. L., Radionova, M., Chavdarov, D., Bratoeva, M., Tzekov, Ch., Pietrangeli, A., Bove, L., Pace, A., Falqui, L., Jandolo, B., Potemkowski, A., Muller B., Reinhard I., Krone A., Warmuth M., Brocker E. M., Krauseneck P., Meyding-Lamadé, U., Krieger, D., Sartor, K., Hacke, W., Maugard-Louboutin, C., Fayet, G., Sagan, C., Martin, S., Ménégalli, D., Lajat, Y., Resche, F., Koriech, O. M., Al Moutaery, K., Yaqub, B., Jochens, R., Wolters, A., Venz, S., Cordes, M., Hecht, B. K., Chatel, M., Gaudray, P., Turc-Carel, C., Gioanni, J., Ayraud, N., Hecht, F., Rumbach, L., Racadot, E., Bataillard, M., Billot, M., Pariset, J., Wijdenes, J., Montalban, Rio J., Tintoré, M., Galan, I., Acarin, N., Rapaport, S., Huberman, M., Shechtcr, D., Karabudak, R., Kilinc, M., Boyacigil, S., Cila, A., Polo, J. M., Setien, S., Sanchez, R., Figols, J., Zubimendi, A., Nadareishvili, Z. G., Massot, R., Marés, R., Gallecho, F., Richart, C., Hernandez, M. A., Garcia, M. R., Lorenzo, J. N., Leon, C., Muros, M., Togores, J., Kutluk, K., Damlacik, G. A., Tekinsoy, B., Obuz, O., Baklan, B., Idiman, E., Genc, K., Zielasek, J., Schmidt, B., Liew, F. Y., Gulay, Z., Yulug, N., Wong, K. S., Wong, T. W., Yu, T. S., Kay, R., Poupon, R., Giral, P., Roberti, C., Zanette, E. M., Chiarotti, F., Brusa, L., Cerbo, R., Prusinski, A., Pondal, M., Canton, R., Dominigo, Erodriguez J., Pereira Monteino J. M., Pereira Monteino X., Pardo, J., Carroacedo, A., Barros, F., Lema, M., Castillo, J., Melchor, A., Montiel, I., Guiu, J. Matias, Kloss, T. M., Keidel, M., Jacob, M., Idiman, F., Idman, E., Ozturk, V., Metin, E., Yilmaz, M., Gerard, J. M., Bouton, R., Decamps, D., Herbaut, A. G., Delecluse, F., Cavenaile, M., Divano, L., Chazot, G., Boureau, F., Emile, J., Bertin, L., d'Allens, H., Ferro, J. M., Costa, I., Carletto, F., Catarci, T., Padovani, A., Iandolo, B., Bartoli, M., Bonamini, M., Pulcinelli, F., Pignatelli, P., Russo, M., Gazzaniga, P. P., Barros, J., Pinheiro, J., Correia, A. P., Monteiro, J. M. Pereira, Alvarez-Cermeno, J. C., Avello, G., Sastre, J. L., Vecino, A., Cesar, J. M., Leone, M., Stankov, B., D'Amico, D., Maltempo, C., Moschian, F., Fraschini, F., Bussone, G., Molto, J. M., Fernandez, E., Fernandez, A. Morento, Barreiro, A., Siclia, J., Castejon, P., Mihout, B., Malberin, M., Salzman, V., Bogousslavsky, J., Meneghetti, G., Baracchini, C., Bozzato, G., Marini, B., Mendel, T., Czlonkowska, A., Pasierski, T., Szwed, H., Marta-Moreno, J., Lopez-Delval, J., Mostacero, E., Morales, F., Mahagne, M. H., Rogopoulos, A., Bertrand, F., Bedoucha, P., Lanteri-Minet, M., Riva, D., Zorzi, C., Milani, N., Vajsar, J., Ronen, G., Macgregor, D., Becker, L., Susseve, J., Seidl, Z., Faber, J., Obenberger, J., Springer, R., Bax, R. T., Eckardt, T., Czettritz, G. V., Emmrich, P., Vlaski-Jekic, S., Petrova, V., Cherninkova, S., Gudeva, T., Tzekov, C., Devoti, M., Franceschetti, S., Mientus, S., Vienna, P., Vashtang, Y., Tazir, M., Assami, S., Oulbani, D., Kaci Ahmed, M. Ait, Andersen, G., Vestergaard, K., Riis, J. O., Chavdarov, D., Corbo, M., Previtali, S., Allen, R. R., McKay, W. C., Rowbotham, M. C., Castellvi-Pel, S., Banchs, I., Kruyer, H., Corral, J., Saugeir-Veber, P., Munnich, A., Bonneau, D., Rozet, J. M., Le Merrer, M., Boespflug-Tanguy, O., Gokyigit, A., Oktem, O., Demir, G., Caliskan, A., Gardiner, R. M., Shorvon, Simon, Wieser, Heinz -Gregor, Hossmann, K. A., Steinberg, A., van Crevel, H., Ducros, A., Labauge, P., Pinsard, N., Ponsot, G., Gouttiere, F., Gastaut, J. L., Delrieu, O., BesanÇon, V., Klopstock, T., May, A., Seibel, P., Papagiannuli, E., Reichmann, H., Gurses, C., Aykut, C., Aktan, S., De Vuono, G., Fiacco, F., Gazzaniga Pozzill, P. P., Assuerus, V., Jacomet, C., Picard, O., Rozenbaum, W., Nueckel, M., Osschmann, P., Horning, C. R., Caldarelli-Stefano, R., Omodeo-Zorini, E., Rivolta, G. E., Maserati, R., Cagni, A., Ferrante, P., Lamadé, W., Heb, Th., Gosztonyl, G., Daral, G., Fresquet, C., Storch-Hagenlocher, B., Wildemann, B., Jager, G., Fuhry, L., Van Paesschen, W., Grunewald, R. A., Duncan, J. S., Connelly, A., Jackson, G. D., Sisodiya, S., Raymond, A. A., Shorvon, S. D., Fish, D. R., Stevens, J. M., Savic, I., Pauli, S., Thorell, J. O., Browne, R. H., Kornhuber, J., Retz, W., Riederer, P., Boon, F., Calliauw, L., Hoksergen, I., Thiery, E., Caemert, J., Decoo, D., Desomer, A., Chevalier, Y., Grinspan, A., Hirsch, E., Moszkowski, J., Marescaux, C., Yaqub, B. A., Valdueza, J. M., Puchner, M. J. A., Dammann, O., Vortmeyer, A., Herrmann, H. -D., Peterson, W., Prevett, M. C., Cunningham, V., Brooks, D. J., Pomes, A., Sunol, C., Durwen, H. F., Confavreux, Ch., Grimaud, J., Saddier, P., Moreau, T., Cortinovis-Tourniaire, P., Aimard, G., Adeleine, P., Paty, D. W., Wiles, C. M., Midgard, R., Riise, T., Kvale, G., Nyland, H., Stodal, H., Haase, A., Lassmann, H., Deeb, S. M. Al., Bruyn, G. W., Semana, G., Teisserenc, H., Alizadeh, M., Loiseau, P., Birebent, B., Yaouanq, J., Genetet, B., Sabouraud, O., Charron, D. J., Shaw, C. E., Stelmasiak, C., Solski, J., Nowicki, J., Jakubowska, B., Ryba, M., Grieb, P., Garcia-Merino, A., Usuku, K., Yunis, E., Alper, C., Hauser, S. L., Betuel, H., Gebuhrer, L., Salier, J. P., Kellar-Wood, H., Govan, G. G., Bromberg, J. E. C., Rinkel, G. J. E., Algra, A., Moulin, T., Stojkovic, T., Chavrot, D., Klotzsch, C., Kaiser-Rub, K., Nahser, H. C., Klijn, C. J. M., Tulleken, C. A. F., Rappelle, L. J., Daffertshofer, M., Kother, J., Hornig, C. R., Rust, D. S., Busse, O., Laun, A., Corabianu, O., Berbinschi, A., Chastang, C., Cophignon, J., Haguenau, M., Ketelslegers, J. M., Jander, S., Kramer, M., Schröter, M., Witte, O. W., Stoll, G., Möbner, R., Barak, V., Sarova-Ponchas, I., Holon, Le Coz, P., Woimant, F., George, B., Merland, J. J., Chleide, E., Casademont, J., Barrientos, A., Cardellach, F., Cervantes, F., Grau, J. M., Montoya, J., Rozman, C., Urbano-Marquez, A., Nunes, V., Lane, R. J. M., Archard, L. C., Schapira, A. H. V., Cooper, J. M., Barnes, P. R. J., Kemp, G. 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M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
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- 1994
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11. Antithrombotic Prophylaxis and Therapy in Renal Failure
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Paar Wd, Kienitz C, and Rosin L
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medicine.medical_specialty ,Acute coronary syndrome ,Creatinine ,medicine.drug_class ,business.industry ,Renal function ,Low molecular weight heparin ,General Medicine ,medicine.disease ,Comorbidity ,Surgery ,chemistry.chemical_compound ,Therapeutic index ,Pharmacokinetics ,chemistry ,Anesthesia ,Antithrombotic ,medicine ,business - Abstract
The authors postulate a “deep compartment” for enoxaparin. This is surprising in view of a distribution volume of some 5 liters and monophasic elimination (compare product information). Because of the structural differences of low molecular weight heparins, the pharmacokinetics of each low molecular weight heparin should be examined individually (1). Such substance specific studies in renal failure have been published for enoxaparin for a long time and have resulted in different dosage recommendations (1, 2, product information). Unfortunately, all this was ignored in the review article. For this reason, the article’s conclusions directly contradict the national and international licensing status of enoxaparin (for example, the US Food and Drug Administration [FDA]’s or the German Federal Institute for Drugs and Medical Devices [BfArM]’s). After repeated subcutaneous administration of the prophylactic dose (40 mg) in patients with a creatinine clearance
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- 2011
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12. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
- Author
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Kirchhof, P., primary, Lip, G. Y. H., additional, Van Gelder, I. C., additional, Bax, J., additional, Hylek, E., additional, Kaab, S., additional, Schotten, U., additional, Wegscheider, K., additional, Boriani, G., additional, Brandes, A., additional, Ezekowitz, M., additional, Diener, H., additional, Haegeli, L., additional, Heidbuchel, H., additional, Lane, D., additional, Mont, L., additional, Willems, S., additional, Dorian, P., additional, Aunes-Jansson, M., additional, Blomstrom-Lundqvist, C., additional, Borentain, M., additional, Breitenstein, S., additional, Brueckmann, M., additional, Cater, N., additional, Clemens, A., additional, Dobrev, D., additional, Dubner, S., additional, Edvardsson, N. G., additional, Friberg, L., additional, Goette, A., additional, Gulizia, M., additional, Hatala, R., additional, Horwood, J., additional, Szumowski, L., additional, Kappenberger, L., additional, Kautzner, J., additional, Leute, A., additional, Lobban, T., additional, Meyer, R., additional, Millerhagen, J., additional, Morgan, J., additional, Muenzel, F., additional, Nabauer, M., additional, Baertels, C., additional, Oeff, M., additional, Paar, D., additional, Polifka, J., additional, Ravens, U., additional, Rosin, L., additional, Stegink, W., additional, Steinbeck, G., additional, Vardas, P., additional, Vincent, A., additional, Walter, M., additional, Breithardt, G., additional, and Camm, A. J., additional
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- 2011
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13. Poster Session 2
- Author
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Andersson, T., primary, Magnusson, A., additional, Bryngelsson, I.- L., additional, Frobert, O., additional, Henriksson, K. M., additional, Edvardsson, N., additional, Poci, D., additional, Polovina, M., additional, Potpara, T., additional, Licina, M., additional, Mujovic, N., additional, Kocijancic, A., additional, Simic, D., additional, Ostojic, M. C., additional, Providencia, R. A., additional, Botelho, A., additional, Trigo, J., additional, Nascimento, J., additional, Quintal, N., additional, Mota, P., additional, Leitao-Marques, A. M., additional, Bosch, R. F., additional, Kirch, W., additional, Rosin, L., additional, Willich, S. N., additional, Pittrow, D., additional, Bonnemeier, H., additional, Valenza, M. C., additional, Martin, L., additional, Munoz Casaubon, T., additional, Valenza, G., additional, Botella, M., additional, Serrano, M., additional, Valenza, B., additional, Cabrera, I., additional, Anderson, K., additional, Benzaquen, B. S., additional, Koziolova, N., additional, Nikonova, J., additional, Shilova, Y., additional, Scherr, D., additional, Narayan, S., additional, Wright, M., additional, Krummen, D., additional, Jadidi, A., additional, Jais, P., additional, Haissaguerre, M., additional, Hocini, M., additional, Hunter, R., additional, Liu, Y., additional, Lu, Y., additional, Wang, W., additional, Schilling, R. J., additional, Bernstein, S., additional, Wong, B., additional, Rooke, R., additional, Vasquez, C., additional, Shah, R., additional, Rosenberg, S., additional, Chinitz, L., additional, Morley, G., additional, Bashir Choudhary, M., additional, Holmqvist, F., additional, Carlson, J., additional, Nilsson, H.- J., additional, Platonov, P. G., additional, Jadidi, A. S., additional, Cochet, H., additional, Miyazaki, S., additional, Shah, A. J., additional, Marrouche, N., additional, Calvo, N., additional, Nadal, M., additional, Andreu, D., additional, Tamborero, D., additional, Diaz, F. E., additional, Berruezo, A., additional, Brugada, J., additional, Mont, L., additional, Fichtner, S., additional, Hessling, G., additional, Estner, H. L., additional, Jilek, C., additional, Reents, T., additional, Ammar, S., additional, Wu, J., additional, Deisenhofer, I., additional, Nakanishi, H., additional, Kashiwase, K., additional, Hirata, A., additional, Wada, M., additional, Ueda, Y., additional, Skoda, J., additional, Neuzil, P., additional, Popelova, J., additional, Petru, J., additional, Sediva, L., additional, Reddy, V. Y., additional, Uldry, L., additional, Forclaz, A., additional, Virag, N., additional, Vesin, J.- M., additional, Kappenberger, L., additional, Sehra, R., additional, Briggs, C., additional, Rappel, W.- J., additional, Janotka, M., additional, Chovanec, M., additional, Yamashiro, K., additional, Takami, K., additional, Sakamoto, Y., additional, Satoh, K., additional, Suzuki, T., additional, Nakagawa, H., additional, Romanov, A., additional, Pokushalov, E., additional, Artemenko, S., additional, Shabanov, V., additional, Stenin, I., additional, Elesin, D., additional, Turov, A., additional, Yakubov, A., additional, Hioki, M., additional, Matsuo, S., additional, Ito, K., additional, Narui, R., additional, Yamashita, S., additional, Sugimoto, K., additional, Yoshimura, M., additional, Yamane, T., additional, Di Biase, L., additional, Gallinghouse, J. D., additional, Rajappan, K., additional, Kautzner, J., additional, Dello Russo, A., additional, Tondo, C., additional, Lorgat, F., additional, Natale, A., additional, Balta, O., additional, Buenz, K., additional, Paessler, M., additional, Anders, H., additional, Horlitz, M., additional, Deneke, T., additional, Lickfett, L., additional, Liberman, I., additional, Linhart, M., additional, Andrie, R., additional, Mittmann-Braun, E., additional, Stockigt, F., additional, Nickenig, G., additional, Schrickel, J., additional, Tilz, R., additional, Rillig, A., additional, Feige, B., additional, Metzner, A., additional, Fuernkranz, A., additional, Burchard, A., additional, Wissner, E., additional, Ouyang, F., additional, Betts, T. R., additional, Jones, M. A., additional, Wong, K. C. K., additional, Qureshi, N., additional, Bashir, Y., additional, Corbucci, G., additional, Losik, D., additional, Selina, V., additional, Crandall, M. A., additional, Daniels, C., additional, Daoud, E., additional, Kalbfleisch, S., additional, Yamaji, H., additional, Murakami, T., additional, Kawamura, H., additional, Murakami, M., additional, Hina, K., additional, Kusachi, S., additional, Dakos, G., additional, Vassilikos, V., additional, Paraskevaidis, S., additional, Mantziari, A., additional, Theophylogiannakos, S., additional, Chouvarda, I., additional, Chatzizisis, I., additional, Styliadis, I., additional, Kimura, T., additional, Fukumoto, K., additional, Nishiyama, N., additional, Aizawa, Y., additional, Fukuda, Y., additional, Sato, T., additional, Miyoshi, S., additional, Takatsuki, S., additional, Navarrete Casas, A. J., additional, Ali, I., additional, Conte, F. C., additional, Moran, M., additional, Graham, B. G., additional, Kalejs, O., additional, Lacis, R., additional, Stradins, P., additional, Koris, A., additional, Putnins, I., additional, Vikmane, M., additional, Lejnieks, A., additional, Erglis, A., additional, Estrada, A., additional, Perez Silva, A., additional, Castrejon, S., additional, Doiny, D., additional, Merino, J. L., additional, Baranchuk, A., additional, Greiss, I., additional, Simpson, C. S., additional, Abdollah, H., additional, Redfearn, D. P., additional, Buys-Topart, M., additional, Nitzsche, R., additional, Thibault, B., additional, Kathan, S., additional, Kolb, C., additional, Reif, S., additional, Schade, S., additional, Taggeselle, J., additional, Frey, A., additional, Birkenhagen, A., additional, Kohler, S., additional, Schmidt, M., additional, Cano Perez, O., additional, Buendia, F., additional, Igual, B., additional, Osca, J. M., additional, Sanchez, J. M., additional, Sancho-Tello, M. J., additional, Olague, J. M., additional, Salvador, A., additional, Tolosana, J. M., additional, Fernandez-Armenta, J., additional, Matas, M., additional, Barbarin, M. C., additional, Habibovic, M., additional, Van Den Broek, K. C., additional, Theuns, D. A. M. J., additional, Jordaens, L., additional, Alings, M., additional, Van Der Voort, P. H., additional, Pedersen, S. S., additional, Pupita, G., additional, Molini, S., additional, Brambatti, M., additional, Capucci, A., additional, Molodykh, S., additional, Idov, E. M., additional, Belyaev, O. V., additional, Segreti, L., additional, Soldati, E., additional, Zucchelli, G., additional, Di Cori, A., additional, Viani, S., additional, Paperini, L., additional, De Lucia, R., additional, Bongiorni, M. G., additional, Binner, L., additional, Taborsky, M., additional, Bello, D., additional, Heuer, H., additional, Ramza, B., additional, Jenniskens, I., additional, Johnson, W. B., additional, Silvetti, M. S., additional, Rava', L., additional, Russo, M. S., additional, Di Mambro, C., additional, Ammirati, A., additional, Gimigliano, G., additional, Prosperi, M., additional, Drago, F., additional, Santos, A. R., additional, Picarra, B., additional, Semedo, P., additional, Dionisio, P., additional, Matos, R., additional, Leitao, M., additional, Jacinto, A., additional, Trinca, M., additional, Mazzone, P., additional, Ciconte, G., additional, Marzi, A., additional, Paglino, G., additional, Vergara, P., additional, Sora, N., additional, Gulletta, S., additional, Della Bella, P., additional, Koppitz, P., additional, Fach, A., additional, Hobbiesiefken, S., additional, Fiehn, E., additional, Hambrecht, R., additional, Sperzel, J., additional, Jung, M., additional, Schmitt, J., additional, Pajitnev, D., additional, Burger, H., additional, Goebel, G., additional, Ehrlich, W., additional, Walther, T., additional, Ziegelhoeffer, T., additional, Vancura, V., additional, Wichterle, D., additional, Melenovsky, V., additional, Glikson, M., additional, Goldenberg, G., additional, Segev, A., additional, Dvir, D., additional, Kuzniec, J., additional, Finkelstein, A., additional, Hay, I., additional, Guetta, V., additional, Choo, W. K., additional, Gupta, S., additional, Kirkfeldt, R., additional, Johansen, J., additional, Nohr, E., additional, Moller, M., additional, Arnsbo, P., additional, Nielsen, J., additional, Banha, M., additional, Stojanov, P., additional, Raspopovic, S., additional, Vasic, D., additional, Savic, D., additional, Nikcevic, G., additional, Jovanovic, V., additional, Defaye, P., additional, Mondesert, B., additional, Mbaye, A., additional, Cassagneau, R., additional, Gagniere, V., additional, Jacon, J., additional, Sanfins, V., additional, Reis, H. R., additional, Nobre, J. N., additional, Martins, V. M., additional, Duarte, L. D., additional, Morais, C. M., additional, Conceicao, J. C., additional, Hero, M., additional, Rey, J. L., additional, Ducharme, A., additional, Simpson, C., additional, Stuglin, C., additional, Blier, L., additional, Senaratne, M., additional, Khaykin, Y., additional, Pinter, A., additional, Mlynarska, A., additional, Mlynarski, R., additional, Sosnowski, M., additional, Wilczek, J., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Dorobantu, M., additional, Radu, A., additional, Vatasescu, R.- G., additional, Yusu, S., additional, Ikeda, T., additional, Mera, H., additional, Miwa, Y., additional, Abe, A., additional, Miyakoshi, M., additional, Tsukada, T., additional, Yoshino, H., additional, Nayar, V., additional, Cantelon, P., additional, Rawling, A., additional, Belham, M. R. D., additional, Pugh, P. J., additional, Osca Asensi, J., additional, Cano, O., additional, Tejada, D., additional, Munoz, B., additional, Rodriguez, M., additional, Olague, J., additional, Wecke, L., additional, Van Hunnik, A., additional, Thompson, T., additional, Di Carlo, L., additional, Zdeblick, M., additional, Auricchio, A., additional, Prinzen, F., additional, Doltra Magarolas, A., additional, Bijnens, B., additional, Silva, E., additional, Penela, D., additional, Sitges, M., additional, Ofman, P., additional, Navaravong, L., additional, Leng, J., additional, Peralta, A., additional, Hoffmeister, P., additional, Levine, R., additional, Cook, J., additional, Stoenescu, M., additional, Tettamanti, M. E., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, De La Fuente Galan, L., additional, Arnold, R., additional, Garcia Moran, E., additional, San Roman Calvar, J. A., additional, Gomez Salvador, I., additional, Nakamura, K., additional, Takami, M., additional, Keida, T., additional, Mesato, A., additional, Higa, S., additional, Shimabukuro, M., additional, Masuzaki, H., additional, Proietti, R., additional, Sagone, A., additional, Domenichini, G., additional, Burri, H., additional, Valzania, C., additional, Biffi, M., additional, Sunthorn, H., additional, Gavaruzzi, G., additional, Foulkes, H., additional, Boriani, G., additional, Koh, S., additional, Hou, W., additional, Snell, J., additional, Poore, J., additional, Dalal, N., additional, Bornzin, G., additional, Kloppe, A., additional, Mijic, D., additional, Bogossian, H., additional, Ninios, I., additional, Zarse, M., additional, Lemke, B., additional, Guedon-Moreau, L., additional, Kouakam, C., additional, Klug, D., additional, Marquie, C., additional, Ziglio, F., additional, Kacet, S., additional, Mohamed Fereig Hamed, H., additional, Hamdy, A. M. A. L., additional, Abd El Aziz, A. H. M. E. D., additional, Nabih, M. R. V. A. T., additional, Hamdy, R. E. H. A. B., additional, Yaminisaharif, A., additional, Davoudi, G. H., additional, Kasemisaeid, A., additional, Sadeghian, S., additional, Vasheghani Farahani, A., additional, Yazdanifard, P., additional, Shafiee, A., additional, Alonso, C., additional, Grimard, C., additional, Jauvert, G., additional, Lazarus, A., additional, Mont, L. L., additional, Ortiz-Perez, J., additional, Caralt, T., additional, Escudero, J., additional, Perez, F., additional, Griffith, K. M., additional, Ferreyra, R., additional, Urena, P., additional, Demas, M., additional, Muratore, C., additional, Mazzetti, H., additional, Guardado, J., additional, Fernandes, M., additional, Pereira, V. H., additional, Canario-Almeida, F., additional, Ferreira, F., additional, Rodrigues, B., additional, Almeida, J., additional, Sokal, A., additional, Jedrzejczyk, E., additional, Lenarczyk, R., additional, Pluta, S., additional, Kowalski, O., additional, Pruszkowska, P., additional, Swiatkowski, A., additional, Kalarus, Z., additional, Heinke, M., additional, Ismer, B., additional, Kuehnert, H., additional, Heinke, T., additional, Surber, R., additional, Osypka, N., additional, Prochnau, D., additional, Figulla, H. R., additional, Iacopino, S., additional, Landolina, M., additional, Proclemer, A., additional, Padeletti, L., additional, Calvi, V., additional, Pierantozzi, A., additional, Di Stefano, P., additional, Bauer, A., additional, Bode, F., additional, Le Gal, F., additional, Deharo, J. C., additional, Delay, M., additional, Clementy, J., additional, Kawamura, M., additional, Munetsugu, Y., additional, Tanno, K., additional, Kobayashi, Y., additional, Cannom, D., additional, Hosoda, J., additional, Ishikawa, T., additional, Andoh, K., additional, Nobuyoshi, M., additional, Fujii, S., additional, Shizuta, S., additional, Isshiki, T., additional, Castel, M. A., additional, Perez-Villa, F., additional, Vidal, B., additional, Pruszkowska-Skrzep, P., additional, Szulik, M., additional, Kukulski, T., additional, Gianfranchi, L., additional, Bettiol, K., additional, Pacchioni, F., additional, Alboni, P., additional, Abu Sham'a, R., additional, Buber, J., additional, Nof, E., additional, Kuperstein, R., additional, Feinberg, M., additional, Luria, D., additional, Eldar, M., additional, Parks, K., additional, Stone, J. R., additional, Singh, J. P., additional, Hatzinikolaou-Kotsakou, E., additional, Kotsakou, M., additional, Beleveslis, T. H., additional, Moschos, G., additional, Reppas, E., additional, Latsios, P., additional, Tsakiridis, K., additional, Kazemisaeid, A., additional, Davoodi, G., additional, Yamini Sharif, A., additional, Sheikhvatan, M., additional, Toniolo, M., additional, Zanotto, G., additional, Rossi, A., additional, Tomasi, L., additional, Vassanelli, C., additional, Versteeg, H., additional, Mommersteeg, P. M. C., additional, Vergara, G., additional, Blauer, J., additional, Ranjan, R., additional, Vijayakumar, S., additional, Kholmovski, E., additional, Volland, N., additional, Macleod, R., additional, Aguinaga Arrascue, L. E., additional, Bravo, A., additional, Garcia Freire, P., additional, Gallardo, P., additional, Hasbani, E., additional, Dantur, J., additional, Quintana, R., additional, Adragao, P. P., additional, Cavaco, D., additional, Parreira, L., additional, Reis Santos, K., additional, Carmo, P., additional, Miranda, R., additional, Marcelino, S., additional, Cabrita, D., additional, Sommer, P., additional, Gaspar, T., additional, Rolf, S., additional, Arya, A., additional, Piorkowski, C., additional, Hindricks, G., additional, Valles Gras, E., additional, Bazan, V., additional, Portillo, L., additional, Suarez, F., additional, Bruguera, J., additional, Marti, J., additional, Huo, Y., additional, Richter, S., additional, Schoenbauer, R., additional, Rivas, N., additional, Casaldaliga, J., additional, Roca, I., additional, Dos, L., additional, Perez-Rodon, J., additional, Pijuan, A., additional, Garcia-Dorado, D., additional, Moya, A., additional, Carter, H. B., additional, Garg, A., additional, Hegrenes, J., additional, Sih, H. J., additional, Teplitsky, L. R., additional, Kuroki, K., additional, Tada, H., additional, Seo, Y., additional, Ishizu, T., additional, Igawa, M., additional, Sekiguchi, Y., additional, Kuga, K., additional, Aonuma, K., additional, Rodriguez A, C., additional, Mejias, J., additional, Hidalgo, P., additional, Hidalgo L, J. A., additional, Orczykowski, M., additional, Derejko, P., additional, Walczak, F., additional, Szufladowicz, E., additional, Urbanek, P., additional, Bodalski, R., additional, Bieganowska, K., additional, Szumowski, L., additional, Peichl, P., additional, Cihak, R., additional, Skalsky, I., additional, Kubus, P., additional, Vit, P., additional, Zaoral, L., additional, Gebauer, R. A., additional, Fiala, M., additional, Janousek, J., additional, Hiroshima, K., additional, Goya, M., additional, Ohe, M., additional, Hayashi, K., additional, Makihara, Y., additional, Nagashima, M., additional, An, Y., additional, Schloesser, M., additional, Lawrenz, T., additional, Meyer Zu Vilsendorf, D., additional, Strunk-Mueller, C., additional, Stellbrink, C., additional, Papagiannis, J., additional, Avramidis, D., additional, Kokkinakis, C., additional, Kirvassilis, G., additional, Eidelman, G., additional, Arenal, A., additional, Datino, T., additional, Atienza, F., additional, Gonzalez Torrecilla, E., additional, Miracle, A., additional, Hernandez, J., additional, Fernandez Aviles, F., additional, Ene, E., additional, Insulander, P., additional, Bastani, H., additional, Braunschweig, F., additional, Drca, N., additional, Kenneback, G., additional, Schwieler, J., additional, Tapanainen, J., additional, Jensen-Urstad, M., additional, Andrea, B., additional, Andrea, E. M. A., additional, Maciel, W. M., additional, Siqueira, L. S., additional, Cosenza, R. C., additional, Mittidieri, F. M., additional, Farah, S. F., additional, Atie, J. A., additional, Kanoupakis, E., additional, Kallergis, E., additional, Mavrakis, H., additional, Goudis, C., additional, Saloustros, I., additional, Malliaraki, N., additional, Chlouverakis, G., additional, Vardas, P., additional, Bonnes, J. L., additional, Jaspers Focks, J., additional, Westra, S. W., additional, Brouwer, M. A., additional, Smeets, J. L. R. M., additional, Inama, G., additional, Pedrinazzi, C., additional, Oliva, F., additional, Senni, M., additional, Zoni Berisso, M., additional, Mostov, S., additional, Haim, M., additional, Nevzorov, R., additional, Hasadi, D., additional, Starsberg, B., additional, Porter, A., additional, Kuschyk, J., additional, Schoene, A., additional, Streitner, F., additional, Veltmann, C. G., additional, Schimpf, R., additional, Borggrefe, M., additional, Luesebrink, U., additional, Gardiwal, A., additional, Oswald, H., additional, Koenig, T., additional, Duncker, D., additional, Klein, G., additional, Bastiaenen, R., additional, Batchvarov, V., additional, Atty, O., additional, Cheng, J. H., additional, Behr, E. R., additional, Gallagher, M. M., additional, Starrenburg, A. H., additional, Kraaier, K., additional, Scholten, M. F., additional, Van Der Palen, J., additional, Adhya, S., additional, Smith, L. A., additional, Zhao, T., additional, Bannister, C., additional, Kamdar, R. H., additional, Martinelli, M., additional, Siqueira, S., additional, Greco, R., additional, Nishioka, S. A. D., additional, Pedrosa, A. A. A., additional, Alkmim-Teixeira, R., additional, Peixoto, G. L., additional, Costa, R., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Johansen, J. B., additional, Kwasniewski, W., additional, Filipecki, A., additional, Urbanczyk-Swic, D., additional, Orszulak, W., additional, Trusz - Gluza, M., additional, Jimenez-Candil, J., additional, Morinigo, J., additional, Ledesma, C., additional, Martin-Luengo, C., additional, Vogtmann, T., additional, Gomer, M., additional, Stiller, S., additional, Kuehlkamp, V., additional, Zach, G., additional, Loescher, S., additional, Kespohl, S., additional, Baumann, G., additional, Snell, J. D., additional, Korsun, N., additional, Snell, J. R., additional, Morley, B., additional, Bharmi, R., additional, Nabutovsky, Y., additional, Mollerus, M., additional, Naslund, L., additional, Meyer, A., additional, Lipinski, M., additional, Libey, B., additional, Dornfeld, K., additional, Martin, A., additional, Gallego, M., additional, De Bie, M. K., additional, Van Rees, J. B., additional, Borleffs, C. J., additional, Thijssen, J., additional, Jukema, J. W., additional, Schalij, M. J., additional, Van Erven, L., additional, Van Der Velde, E. T., additional, Witteman, T. A., additional, Foeken, H., additional, Szili-Torok, T., additional, Akca, F., additional, Caliskan, K., additional, Ten Cate, F., additional, Michels, M., additional, Cozma, D. C., additional, Petrescu, L., additional, Mornos, C., additional, Dragulescu, S. I., additional, Groeneweg, J. A., additional, Velthuis, B. K., additional, Cox, M. G. P. J., additional, Loh, P., additional, Dooijes, D., additional, Cramer, M. J., additional, De Bakker, J. M. T., additional, Hauer, R. N. W., additional, Park, S. D., additional, Shin, S. H., additional, Woo, S. I., additional, Kwan, J., additional, Park, K. S., additional, Kim, D. H., additional, Iorio, A., additional, Vitali Serdoz, L., additional, Brun, F., additional, Daleffe, E., additional, Zecchin, M., additional, Dal Ferro, M., additional, Santangelo, S., additional, Sinagra, G. F., additional, Ouali, S., additional, Hammemi, R., additional, Hammas, S., additional, Kacem, S., additional, Gribaa, R., additional, Neffeti, E., additional, Remedi, F., additional, Boughzela, E., additional, Korantzopoulos, P., additional, Letsas, K., additional, Christogiannis, Z., additional, Kalantzi, K., additional, Ntorkos, A., additional, Goudevenos, J., additional, Foley, P. W. X., additional, Yung, L., additional, Barnes, E., additional, Kikuchi, M., additional, Ito, H., additional, Miyoshi, F., additional, Pecini, R., additional, Marott, J. M., additional, Jensen, G. B., additional, Theilade, J., additional, Mine, T., additional, Kodani, T., additional, Masuyama, T., additional, Mozos, I. M., additional, Serban, C., additional, Costea, C., additional, Susan, L., additional, Barthel, P., additional, Mueller, A., additional, Malik, M., additional, Schmidt, G., additional, Karakurt, O., additional, Kilic, H., additional, Munevver Sari, D. R., additional, Mroczek-Czernecka, D., additional, Pietrucha, A. Z., additional, Borowiec, A., additional, Wnuk, M., additional, Bzukala, I., additional, Kruszelnicka, O., additional, Konduracka, E., additional, Nessler, J., additional, Kikuchi, Y., additional, Meireles, A., additional, Gomes, C., additional, Anjo, D., additional, Roque, C., additional, Pinheiro Vieira, A., additional, Lagarto, V., additional, Hipolito Reis, A., additional, Torres, S., additional, Miller, L., additional, Vedrenne, G., additional, Bruguiere, E., additional, Redheuil, A., additional, Lavergne, T., additional, Le Heuzey, J. Y., additional, Mousseaux, E., additional, Hersi, A., additional, Alhabib, K., additional, Alfaleh, H., additional, Sulaiman, K., additional, Almahmeed, W., additional, Alsuwidi, J., additional, Amin, H., additional, Almotarreb, A., additional, Pang, H. W. K., additional, Michael, K., additional, Pereira, E. J., additional, Munt, P. W., additional, Fitzpatrick, M. F., additional, Revishvili, A. S., additional, Simonyan, G., additional, Dzhordzhikiya, T., additional, Sopov, O., additional, Kalinin, V., additional, Locati, E. T., additional, Vecchi, A. M., additional, Cattafi, G., additional, Sachero, A., additional, Lunati, M., additional, Sayah, S., additional, Alizadeh, A., additional, Nazari, N., additional, Hekmat, M., additional, Moradi, M., additional, Zeighami, M., additional, Ghanji, H., additional, Suzuki, K., additional, Takagi, M., additional, Maeda, K., additional, Tatsumi, H., additional, Vieira, P., additional, Reis, H., additional, Toth, A., additional, Vago, H., additional, Takacs, P., additional, Edes, E., additional, Marki, A., additional, Balazs, G. Y., additional, Huttl, K., additional, Merkely, B., additional, Lainis, F., additional, Buckley, M. M., additional, Johns, E. J., additional, Seifer, C. M., additional, Daba, L., additional, Liebrecht, K., additional, Piwowarska, W., additional, Toquero Ramos, J., additional, Perez Pereira, E., additional, Mitroi, C., additional, Castro Urda, V., additional, Fernandez Villanueva, J. M., additional, Corona Figueroa, A., additional, Hernandez Reina, L., additional, Fernandez Lozano, I., additional, Bartoletti, A., additional, Bocconcelli, P., additional, Giuli, S., additional, Massa, R., additional, Svetlich, C., additional, Tarsi, G., additional, Tronconi, F., additional, Vitale, E., additional, Stryjewski, P., additional, Wegrzynowska, M., additional, Lousinha, A., additional, Labandeiro, J., additional, Antunes, E., additional, Silva, S., additional, Alves, S., additional, Timoteo, A., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, and Jedrzejczyk-Spaho, J., additional
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- 2011
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14. Gesundheitsbezogene Lebensqualität bei Patienten mit Vorhofflimmern in der kardiologischen Versorgung: MOVE-Studie
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Kirch, W, primary, Pittrow, D, additional, Bosch, R, additional, Kohlhaußen, A, additional, Willich, S, additional, Rosin, L, additional, and Bonnemeier, H, additional
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- 2010
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15. Niedermolekulare Heparine zur Thromboseprophylaxe nach ischämischem Schlaganfall
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Diener, H.-C., primary, Röther, J., additional, Rosin, L., additional, and Bramlage, P., additional
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- 2007
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16. Karotisendarteriektomie und Karotisstenting
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Link, J., primary, Manke, C., additional, Rosin, L., additional, Borisch, I., additional, Töpel, I., additional, Horn, M., additional, Mann, S., additional, Jauch, K.-W., additional, Bogdahn, U., additional, Feuerbach, St., additional, and Kasprzak, P., additional
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- 2000
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17. Stiff-man syndrome in a woman with breast cancer
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Rosin, L., primary, DeCamilli, P., additional, Butler, M., additional, Solimena, M., additional, Schmitt, H.-P., additional, Morgenthaler, N., additional, and Meinck, H.-M., additional
- Published
- 1998
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18. Neurological aspects of patent foramen ovale: in search of the optimal treatment.
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ROSIN, LUDGER and Rosin, L
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- 2001
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19. Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization
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Levin, I., Cohen, J., Supino-Rosin, L., Yoshimura, A., Watowich, S. S., and Neumann, D.
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- 1998
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20. Preservative toxicity in glaucoma medication: clinical evaluation of benzalkonium chloride-free 0.5% timolol eye drops
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Rosin LM and Bell NP
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Ophthalmology ,RE1-994 - Abstract
Lauren M Rosin,1 Nicholas P Bell1,2 1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, 2Robert Cizik Eye Clinic, Houston, TX, USA Abstract: Timolol (generic name) is a frequently used medication for the control of glaucoma. Benzalkonium chloride (BAK) is a commonly used preservative in ophthalmic solutions with a broad range of antimicrobial activity; however, this nonspecificity can result in toxicity. Adverse effects attributed to BAK, including conjunctival inflammation and fibrosis, tear film instability, corneal cytotoxicity, anterior chamber inflammation, trabecular meshwork cell apoptosis, cataract development, macular edema, and even systemic effects, have been well documented. These effects can lead to ocular discomfort, poor intraocular pressure control, glaucoma surgery failure, and decreased patient compliance. BAK use in topical medications has decreased recently as newer and less toxic preservatives have become available. Yet these preservatives still exert some toxic effects, especially in patients with chronic eye disease who use multiple drops over extended periods of time. Thus, attempts to reduce overall preservative loads for patients are important, whether it be decreasing the amount of preservative, decreasing the total number of drops patients use, or eliminating preservatives entirely. A preservative-free formulation of timolol, TIMOPTIC® in OCUDOSE®, is available in unit-dose vials. Preservative-free unit-dose vials minimize toxic adverse effects and are a good option for patients with ocular surface disease, on long-term multidrop therapy, or who simply do not tolerate the effects of preservatives due to discomfort. Keywords: glaucoma, ocular toxicity, benzalkonium chloride, preservative-free timolol
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- 2013
21. Erythropoietin and its receptor: signaling and clinical manifestations
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Cohen J, Supino-Rosin L, Eran Barzilay, Eisen-Lev R, Mittelman M, and Neumann D
22. ARID1A spatially partitions interphase chromosomes
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Wu S., Fatkhutdinov N., Rosin L., Luppino J., Iwasaki O., Tanizawa H., Tang H., Kossenkov A., Gardini A., Noma K., Speicher D., Joyce E., Zhang R., Wu S., Fatkhutdinov N., Rosin L., Luppino J., Iwasaki O., Tanizawa H., Tang H., Kossenkov A., Gardini A., Noma K., Speicher D., Joyce E., and Zhang R.
- Abstract
© 2019 by the Authors. ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in higher-order spatial chromosome partitioning and genome organization is unknown. Here, we show that ARID1A spatially partitions interphase chromosomes and regulates higher-order genome organization. The SWI/SNF complex interacts with condensin II, and they display significant colocalizations at enhancers. ARID1A knockout drives the redistribution of condensin II preferentially at enhancers, which positively correlates with changes in transcription. ARID1A and condensin II contribute to transcriptionally inactive B-compartment formation, while ARID1A weakens the border strength of topologically associated domains. Condensin II redistribution induced by ARID1A knockout positively correlates with chromosome sizes, which negatively correlates with interchromosomal interactions. ARID1A loss increases the trans interactions of small chromosomes, which was validated by three-dimensional interphase chromosome painting. These results demonstrate that ARID1A is important for large-scale genome folding and spatially partitions interphase chromosomes.
23. Microalbuminuria indicates long-term vascular risk in patients after acute stroke undergoing in-patient rehabilitation
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Sander Dirk, Weimar Christian, Bramlage Peter, Brandt Tobias, Rosin Ludger, and Siebler Mario
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Patients in neurologic in-patient rehabilitation are at risk of cardio- and cerebrovascular events. Microalbuminuria (MAU) is frequent and an important risk predictor but has not been validated in in-patient rehabilitation. We therefore aimed to examine MAU as an indicator of risk and predictor of vascular events in a prospective study. Methods The INSIGHT (INvestigation of patients with ischemic Stroke In neuroloGic reHabiliTation) registry is the first to provide large scale data on 1,167 patients with acute stroke (< 3 months) that survived the initial phase of high risk and were undergoing neurologic in-patient rehabilitation. MAU was determined by dipstick-testing and correlated to baseline clinical variables (stroke-origin, functional impairment, co-morbidity, ankle-brachial-index, intima-media-thickeness) as well as vascular events after one year of follow-up. Comparisons were made with the χ2 or Mann–Whitney-U Test. Relative risks (RR) with 95% confidence intervals (CI) were estimated using log-binominal models. To evaluate the association between MAU and new vascular events as well as mortality, we calculated hazard ratios (HR) using Cox proportional hazard regression. Results A substantial proportion of patients was MAU positive at baseline (33.1%). Upon univariate analysis these patients were about 4 years older (69 vs. 65 years; p 2; p = 0.03) and increased waist circumference (79.5 vs. 50.4% for women [p Conclusions INSIGHT demonstrated a significant association between MAU and polyvascular disease and further supports previous findings that MAU predicts cardio-/cerebrovascular events in patients recovering from ischemic stroke. This biomarker may also be used in patients during neurologic in-patient rehabilitation, opening a window of opportunity for early intervention in this patient group at increased risk for recurrent events.
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- 2012
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24. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
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Giuseppe Boriani, Andreas Goette, Isabelle C. Van Gelder, Gerhard Steinbeck, Ursula Ravens, Carina Blomström-Lundqvist, Stephan Willems, Luis Mont, Paulus Kirchhof, Andreas Clemens, Nilo B. Cater, Robert Hatala, Axel Brandes, A. John Camm, Stefan Kääb, Jeroen J. Bax, Guenter Breithardt, Leif Friberg, Maria Borentain, Karl Wegscheider, Juergen Polifka, Dieter Paar, Michael Nabauer, Hein Heidbuchel, Michele Massimo Gulizia, Trudie Lobban, Ulrich Schotten, Josef Kautzner, Elaine M. Hylek, John M. Morgan, Wim Stegink, Lukas Szumowski, Paul Dorian, Jenny Horwood, Angelika Leute, Ralf Meyer, Alphons Vincent, Dobromir Dobrev, Deirdre A. Lane, Stefanie Breitenstein, Hans-Christoph Diener, Laurent M. Haegeli, Nils Edvardsson, Michael Oeff, Michael D. Ezekowitz, Lukas Kappenberger, Sergio Dubner, Gregory Y.H. Lip, Christoph Baertels, Panos E. Vardas, Martina Brueckmann, Maria Aunes-Jansson, Felix Muenzel, Maureen V Walter, Jay Millerhagen, Ludger Rosin, Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Brandes A, Ezekowitz M, Diener H, Haegeli L, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Aunes-Jansson M, Blomstrom-Lundqvist C, Borentain M, Breitenstein S, Brueckmann M, Cater N, Clemens A, Dobrev D, Dubner S, Edvardsson NG, Friberg L, Goette A, Gulizia M, Hatala R, Horwood J, Szumowski L, Kappenberger L, Kautzner J, Leute A, Lobban T, Meyer R, Millerhagen J, Morgan J, Muenzel F, Nabauer M, Baertels C, Oeff M, Paar D, Polifka J, Ravens U, Rosin L, Stegink W, Steinbeck G, Vardas P, Vincent A, Walter M, Breithardt G, Camm AJ., Fysiologie, and RS: CARIM School for Cardiovascular Diseases
- Subjects
Male ,Heart disease ,Medizin ,antithrombotic therapy ,Management of atrial fibrillation ,outcomes ,GLOMERULAR-FILTRATION-RATE ,ATRIAL FIBRILLATION ,BIOLOGICAL MARKERS ,TREATMENT OUTCOME ,Antithrombotic ,Atrial Fibrillation ,RADIOFREQUENCY CATHETER ABLATION ,risk factors ,rhythm control ,early therapy ,CARDIOVASCULAR INTERVENTIONS EAPCI ,Atrial fibrillation ,C-REACTIVE PROTEIN ,VENTRICULAR SYSTOLIC DYSFUNCTION ,Treatment Outcome ,Female ,Cardiology and Cardiovascular Medicine ,Anti-Arrhythmia Agents ,management ,medicine.medical_specialty ,Long QT syndrome ,MEDLINE ,Reviews ,LONG-QT SYNDROME ,Early Therapy ,CARDIOLOGY WORKING GROUP ,CEREBRAL AMYLOID ANGIOPATHY ,Fibrinolytic Agents ,Physiology (medical) ,medicine ,Animals ,Humans ,STERILE PERICARDITIS MODEL ,Intensive care medicine ,LOBAR INTRACEREBRAL HEMORRHAGE ,rate control ,business.industry ,medicine.disease ,Rats ,business ,Risk Reduction Behavior ,Fibrinolytic agent ,Biomarkers - Abstract
While management of atrial fibrillation (AF) patients is improved by guideline-conform application of anticoagulant therapy, rate control, rhythm control, and therapy of accompanying heart disease, the morbidity and mortality associated with AF remain unacceptably high. This paper describes the proceedings of the 3rd Atrial Fibrillation NETwork (AFNET)/European Heart Rhythm Association (EHRA) consensus conference that convened over 60 scientists and representatives from industry to jointly discuss emerging therapeutic and diagnostic improvements to achieve better management of AF patients. The paper covers four chapters: (i) risk factors and risk markers for AF; (ii) pathophysiological classification of AF; (iii) relevance of monitored AF duration for AF-related outcomes; and (iv) perspectives and needs for implementing better antithrombotic therapy. Relevant published literature for each section is covered, and suggestions for the improvement of management in each area are put forward. Combined, the propositions formulate a perspective to implement comprehensive management in AF.
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- 2012
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25. Unique territorial and compartmental organization of chromosomes in the holocentric silkmoth.
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Gil J Jr, Navarrete E, Rosin LF, Chowdhury N, Abraham S, Cornilleau G, Lei EP, Mozziconacci J, Mirny LA, Muller H, and Drinnenberg IA
- Abstract
The hallmarks of chromosome organization in multicellular eukaryotes are chromosome territories (CT), chromatin compartments, and insulated domains, including topologically associated domains (TADs). Yet, most of these elements of chromosome organization are derived from analyses of a limited set of model organisms, while large eukaryotic groups, including insects, remain mostly unexplored. Here we combine Hi-C, biophysical modeling, and microscopy to characterize the 3D genome architecture of the silkmoth, Bombyx mori . In contrast to other eukaryotes, B. mori chromosomes form highly separated territories. Similar to other eukaryotes, B. mori chromosomes segregate into active A and inactive B compartments, yet unlike in vertebrate systems, contacts between euchromatic A regions appear to be a strong driver of compartmentalization. Remarkably, we also identify a third compartment, called secluded "S," with a unique contact pattern. Each S region shows prominent short-range self-contacts and is remarkably devoid of contacts with the rest of the chromosome, including other S regions. Compartment S hosts a unique combination of genetic and epigenetic features, localizes towards the periphery of CTs, and shows developmental plasticity. Biophysical modeling reveals that the formation of such secluded domains requires highly localized loop extrusion within them, along with a low level of extrusion in A and B. Our Hi-C data supports predicted genome-wide and localized extrusion. Such a broad, non-uniform distribution of extruders has not been seen in other organisms. Overall, our analyses support loop extrusion in insects and highlight the evolutionary plasticity of 3D genome organization, driven by a new combination of known processes.
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- 2024
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26. Rates of clinical remission and inadequate response to advanced therapies among patients with ulcerative colitis in Germany.
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Bokemeyer B, Picker N, Kromer D, Rosin L, and Patel H
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- Humans, Adult, Retrospective Studies, Treatment Outcome, Remission Induction, Colitis, Ulcerative drug therapy, Biological Products therapeutic use
- Abstract
Purpose: Many patients treated for ulcerative colitis (UC) do not achieve clinical remission. This real-world study assessed clinical remission and inadequate response rates among patients with UC in Germany treated with advanced therapies., Methods: This retrospective chart review included patients with UC newly initiating advanced (index) therapy (anti-TNFα agents, vedolizumab, tofacitinib) from January 2017-September 2019 (index date). Included patients had data for ≥ 12 months before (baseline period) and after the index date (follow-up period). Remission was defined as a partial Mayo score ≤ 1. Indicators of inadequate response were: index therapy discontinuation; therapy adjustments (index therapy dose escalation; augmentation with non-advanced therapies; corticosteroid [CS] use during maintenance therapy); CS dependency (use for ≥ 12 weeks); and UC-related hospitalisation, surgery or emergency department visit. Time to first remission and inadequate response were analyzed using Kaplan-Meier analyses., Results: Among 149 patients with UC (median age: 40 years), 96 (64.4%) were biologic-naïve and 42 (28.2%) received CS at the index date. Within 12 months, 52 patients (47.2%) were in remission; of these, 13 patients (25.0%) received ≥ 1 therapy adjustment. At 12 months, 55 patients (37.6%) had ≥ 1 indicator of an inadequate response. Median time to remission was longer among biologic-experienced vs biologic-naïve patients (24 vs 7 months; p = 0.012)., Conclusion: Over half of the patients were not in clinical remission after 12 months and more than one-third experienced inadequate response. One-quarter of patients in remission required therapy adjustments. Patients with UC require therapies that are more effective than those currently available to achieve better treatment outcomes., (© 2023. The Author(s).)
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- 2023
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27. Screening for non-classic congenital adrenal hyperplasia in women: New insights using different immunoassays.
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Nakhleh A, Saiegh L, Shehadeh N, Weintrob N, Sheikh-Ahmad M, Supino-Rosin L, Alboim S, Gendelman R, and Zloczower M
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- Humans, Female, Retrospective Studies, 17-alpha-Hydroxyprogesterone, Immunoassay, Cosyntropin, Follicle Stimulating Hormone, Adrenal Hyperplasia, Congenital diagnosis
- Abstract
Context: The 250µg-cosyntropin stimulation test (CST) is used to diagnose non-classic congenital adrenal hyperplasia (NCCAH). The current recommendation is to perform CST when follicular 17-hydroxyprogesterone (17OHP) is 6-30 nmol/L, a cutoff derived from radioimmunoassay (RIA). Recently, enzyme-linked immunosorbent assay (ELISA) has replaced RIA., Objectives: We aimed to (1) determine the RIA and ELISA-based 17OHP cutoffs at which CST should be performed, (2) identify predictors of NCCAH., Methods: A retrospective study at an Israeli Health Maintenance Organization. Data were retrieved from women with suspected NCCAH, referred for CST during 2001-2020. NCCAH was defined as a stimulated 17OHP >30 nmol/L. Serum 17OHP levels were assayed by RIA from 1/2000-3/2015, and by ELISA from 4/2015-12/2020. ROC curves were generated and optimal 17OHP thresholds were determined. Multivariate analysis was performed., Results: CST was performed in 2409 women (1564 in RIA, 845 in ELISA). NCCAH was diagnosed in 4.7% of the RIA group and 7.5% of the ELISA group. The optimal basal 17OHP cutoff values predicting NCCAH were 6.1 nmol/L in RIA (sensitivity=93.2%, specificity=91.7%) and 8.2 nmol/L in ELISA (sensitivity=93.7%, specificity=92.3%). In multivariate analysis, higher basal 17OHP, lower LH: FSH ratio, and oligomenorrhea were predictors of NCCAH in RIA. Higher basal 17OHP, androstenedione, and total testosterone were predictors of NCCAH in ELISA. A lower LH: FSH ratio showed similar trend in ELISA., Conclusions: Optimal RIA-based basal 17OHP cutoff was comparable with that recommended in guidelines. The results suggest adopting a higher 17OHP cutoff when using ELISA. LH : FSH ratio improves the negative predictive value of basal 17OHP., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Nakhleh, Saiegh, Shehadeh, Weintrob, Sheikh-Ahmad, Supino-Rosin, Alboim, Gendelman and Zloczower.)
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- 2023
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28. Inadequate Response, Treatment Patterns, Health Care Utilization, and Associated Costs in Patients With Ulcerative Colitis: Retrospective Cohort Study Based on German Claims Data.
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Bokemeyer B, Picker N, Wilke T, Rosin L, and Patel H
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- Humans, Female, Adult, Retrospective Studies, Infliximab therapeutic use, Adalimumab therapeutic use, Patient Acceptance of Health Care, Health Care Costs, Colitis, Ulcerative drug therapy
- Abstract
Background: Real-world data regarding response rates in ulcerative colitis treatment are rare, particularly for later lines of therapy. This study aimed to assess continuity of and changes to advanced therapies, as well as costs and specific indicators defining suboptimal therapy., Methods: German claims data were retrospectively analyzed (January 2014 to June 2019). Patients with ulcerative colitis initiating an advanced therapy (adalimumab, golimumab, infliximab, tofacitinib, vedolizumab) were included. Inadequate response was indicated by therapy discontinuation, switch, escalation, augmentation, corticosteroid dependency, disease-related hospitalization, or surgery. Health care resource utilization (inpatient, outpatient, sick leaves, medication, aids, and remedies) and related costs were assessed from therapy initiation until discontinuation or loss to follow-up., Results: Among 574 patients (median age, 39 years; female sex, 53.5%) who initiated advanced therapies, 458 (79.8%) received an antitumor necrosis factor therapy, 113 (19.7%) vedolizumab, and 3 (0.5%) tofacitinib. After 12 months, 75% had ≥1 indicator for suboptimal therapy. The median time to first indicated inadequate response was 4.8 months. Therapy discontinuation (38%), switching (26%), and prolonged use of steroids (36%) were common within the first year of treatment. In an unadjusted comparison, all-cause total costs per person-year were significantly higher in those who switched vs patients remaining on their therapy (€44,570 vs €36,807; P < .001)., Conclusions: Our study indicates a high prevalence of inadequate response to advanced therapies. Only 25% of patients showed adequate response within 12 months after therapy initiation. Frequent dose and treatment changes were observed. The economic impact of suboptimal therapy in ulcerative colitis is substantial, highlighting the ongoing need for improved treatment strategies., (© 2022 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.)
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- 2022
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29. SARS-CoV-2 spike IgG titres up to 137 days following Comirnaty mRNA COVID-19 vaccination, Israel, February to May 2021.
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Patalon T, Ben Moshe S, Peretz A, Neuberger A, Schreiber L, Lazar R, Supino-Rosin L, Perez G, Mizrahi-Reuveni M, and Gazit S
- Subjects
- Antibodies, Viral, COVID-19 Vaccines, Female, Humans, Immunoglobulin G, Israel epidemiology, Male, RNA, Messenger, Retrospective Studies, Vaccination, COVID-19 prevention & control, SARS-CoV-2 genetics
- Abstract
BackgroundData regarding the long-term protection afforded by vaccination for the SARS-CoV-2 infection are essential for allocation of scarce vaccination resources worldwide.MethodsWe conducted a retrospective cohort study aimed at studying the kinetics of IgG antibodies against SARS-CoV-2 in COVID-19-naïve patients fully vaccinated with two doses of Comirnaty mRNA COVID-19 vaccine. Geometric mean concentrations (GMCs) of antibody levels were reported. Linear models were used to assess antibody levels after full vaccination and their decline over time.ResultsThe study included 4,740 patients and 5,719 serological tests. Unadjusted GMCs peaked 28-41 days after the first dose at 10,174 AU/mL (95% CI: 9,211-11,237) and gradually decreased but remained well above the positivity cut-off. After adjusting for baseline characteristics and repeated measurements, the antibodies half-life time was 34.1 days (95% CI: 33.1-35.2), and females aged 16-39 years with no comorbidities had antibody levels of 20,613 AU/mL (95% CI: 18,526-22,934) on day 28 post-first-dose. Antibody levels were lower among males (0.736 of the level measured in females; 95% CI: 0.672-0.806), people aged 40-59 (0.729; 95% CI: 0.649-0.818) and ≥ 60 years (0.452; 95% CI: 0.398-0.513), and patients having haematological (0.241; 95% CI: 0.190-0.306) or solid malignancies (0.757; 95% CI: 0.650-0.881), chronic kidney disease with glomerular filtration rate (GFR) ≥ 30 (0.434; 95% CI: 0.354-0.532) or with GFR < 30 mL/min (0.176; 95% CI: 0.109-0.287), and immunosuppression (0.273; 95% CI: 0.235-0.317). Body mass index, cardiovascular disease, congestive heart failure, chronic obstructive pulmonary disease, diabetes and inflammatory bowel diseases were not associated with antibody levels.ConclusionsVaccination with two doses resulted in persistently high levels of antibodies (≥ cut-off of 50 AU/mL) up to 137 days post-first-dose. Risk factors for lower antibody levels were identified.
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- 2022
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30. Robust antibody response after a third BNT162b2 vaccine compared to the second among immunocompromised and healthy individuals, a prospective longitudinal cohort study.
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Shapiro Ben David S, Mizrahi B, Rahamim-Cohen D, Supino-Rosin L, Shahar A, Hermoni-Alon S, Fremder Sacerdote A, Irony A, Lazar R, Kalkstein N, Lustig Y, Indenbaum V, Landsberger D, Mizrahi-Reuveni M, and Shapira S
- Subjects
- Antibodies, Viral, Antibody Formation, BNT162 Vaccine, Female, Humans, Immunoglobulin G, Longitudinal Studies, Male, Middle Aged, Prospective Studies, SARS-CoV-2, COVID-19 prevention & control, Vaccines
- Abstract
Purpose: As protection from COVID-19 following two doses of the BNT162b2 vaccine showed a time dependent waning, a third (booster) dose was administrated. This study aims to compare the antibody response following the third dose versus the second and to evaluate post-booster seroconversion., Methods: A prospective observational study conducted in Maccabi Healthcare Services. Serial SARS-CoV-2 Spike IgG tests, 1,2,3 and 6 months following the second vaccine dose and one month following the third were obtained. Neutralizing antibody levels were measured in a subset of participants. Per individual SARS-CoV-2 Spike IgG titer ratios were calculated one month after the booster administration compared to titers one month following the second dose and prior to booster., Results: Among 110 participants,56 (51%) were women. Mean age was 61.7 ± 1.9 years and 66 (60%) were immunocompromised. One month after third dose, IgG titers were induced 7.83 (95 %CI 5.25-11.67) folds and 2.40 (95 %CI 1.90-3.03) folds compared to one month after the second, in the immunocompromised and immunocompetent groups, respectively. Of the 17 immunocompromised participants who were seronegative after the second dose, 4 (24%) became seropositive following the third. Comparing the titers prior to the third dose, an increase of 50.7 (95 %CI 32.5-79.1) fold in the immunocompromised group and 25.7 (95 %CI 19.1-34.7) fold in and immunocompetent group, was observed., Conclusion: A third BNT162b2 vaccine elicited robust humoral response, superior to the response observed following the second, among immunocompetent and immunocompromised individuals., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2022
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31. Comparison of Covid-19 antibody status after vaccination between residents in long-term geriatric care and residents assisted-living facilities.
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Naschitz JE, Kertes J, Pinto G, Zaigraykin N, Oz D, Goland E, Nasser S, Supino-Rosin L, Lazar R, and Ekka-Zohar A
- Subjects
- Aged, Antibodies, Viral, COVID-19 Vaccines, Humans, SARS-CoV-2, Vaccination, BNT162 Vaccine, COVID-19
- Abstract
Objective: To compare 2 CoV-SARS-2 ('anti-s') antibody levels after vaccination between residents in long-term geriatric care (LTGC) and residents in assisted-living facilities who had received two doses of the BNT162b2 vaccine. SARS-CoV-2 serology was tested with Quant II IgG CoV-SARS-2. Blood samples were collected 3-4 months after administration of the second vaccine dose., Results: Anti-s ≥ 50 AU/ml was found in 85.4% of 90 residents in LTGC (median 498 AU/ml) and 94.9% of 214 residents in assisted living (median 728 AU/ml). p = .006. Factors associated with anti-s < 300 AU/ml were multi-morbidity, diabetes mellitus and cancer.
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- 2022
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32. Effectiveness of mRNA BNT162b2 Vaccine 6 Months after Vaccination among Patients in Large Health Maintenance Organization, Israel.
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Kertes J, Gez SB, Saciuk Y, Supino-Rosin L, Stein NS, Mizrahi-Reuveni M, and Zohar AE
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- COVID-19 Vaccines, Health Maintenance Organizations, Humans, Israel epidemiology, RNA, Messenger, Vaccination, BNT162 Vaccine, COVID-19
- Abstract
Israel experienced a new wave of coronavirus disease during June 2021, six months after implementing a national vaccination campaign. We conducted 3 discrete analyses using data from a large health maintenance organization in Israel to determine whether IgG levels of fully vaccinated persons decrease over time, describe the relationship between IgG titer and subsequent PCR-confirmed infection, and compare PCR-confirmed infection rates by period of vaccination. Mean IgG levels steadily decreased over the 6-month period in the total tested population and in all age groups. An inverse relationship was found between IgG titer and subsequent PCR-positive infection. Persons vaccinated during the first 2 months of the campaign were more likely to become infected than those subsequently vaccinated. The vaccinated group >60 years of age had lower initial IgG levels and were at greater risk for infection. The findings support the decision to add a booster vaccine for persons >60 years of age.
- Published
- 2022
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33. Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination.
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Grupel D, Gazit S, Schreiber L, Nadler V, Wolf T, Lazar R, Supino-Rosin L, Perez G, Peretz A, Ben Tov A, Mizrahi-Reuveni M, Chodick G, and Patalon T
- Subjects
- BNT162 Vaccine, COVID-19 Vaccines, Humans, Immunoglobulin G, Kinetics, Retrospective Studies, Vaccination, COVID-19, SARS-CoV-2
- Abstract
Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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34. Increased incidence of coeliac disease autoimmunity rate in Israel: a 9-year analysis of population-based data.
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Lechtman N, Shamir R, Cohen S, Chodick G, Kariv R, Supino-Rosin L, Weintraub Y, Yerushalmy-Feler A, and Ben Tov A
- Subjects
- Adult, Autoimmunity, Child, Child, Preschool, Europe, Humans, Incidence, Infant, Infant, Newborn, Israel epidemiology, Middle Aged, Retrospective Studies, Transglutaminases, Celiac Disease diagnosis, Celiac Disease epidemiology
- Abstract
Background: Incidence rate and temporal trends in coeliac disease and coeliac disease autoimmunity incidence vary worldwide with most data available from North American and European countries., Aims: To explore temporal trends in incidence of coeliac disease autoimmunity and their relation to increase in screening tests in Israel., Methods: A large retrospective population-based study was conducted in Maccabi Healthcare Services, a 2.3-million-member health maintenance organisation operating in Israel. The cohort included all patients with newly diagnosed coeliac disease autoimmunity based on first positive anti-tissue transglutaminase type 2 IgA antibodies. Data were analysed for the years 2007-2015., Results: During the study period (17.3 million person-years), a total of 403 283 patients were tested for coeliac disease autoimmunity, of whom 6444 were positive, representing an average incidence rate of 36.64 per 100 000 person-years (95% CI: 35.74-37.55). Incidence of coeliac disease autoimmunity increased from 25.4 per 100 000 in 2007 to 52.3 per 100 000 person-years in 2015 (Incidence rate ratio of 2.06, 95% CI 1.81-2.26). Coeliac disease autoimmunity incidence was highest in the paediatric age groups, especially in children aged 0-5, and was 4 times higher than the incidence in adults aged 26-55 (Incidence rate ratio of 0.24, 95% CI (0.22-0.26). The increase in incidence surpassed the increase in testing for new patients. Positive trends in incidence were highest in small children, whereas the incidence in adults was stable over the years., Conclusions: There was a steady increase in coeliac disease autoimmunity incidence in our cohort between the years 2007-2015. The paediatric population was the only contributor to this trend., (© 2021 John Wiley & Sons Ltd.)
- Published
- 2021
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35. Multi-center nationwide comparison of seven serology assays reveals a SARS-CoV-2 non-responding seronegative subpopulation.
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Oved K, Olmer L, Shemer-Avni Y, Wolf T, Supino-Rosin L, Prajgrod G, Shenhar Y, Payorsky I, Cohen Y, Kohn Y, Indenbaum V, Lazar R, Geylis V, Oikawa MT, Shinar E, Stoyanov E, Keinan-Boker L, Bassal R, Reicher S, Yishai R, Bar-Chaim A, Doolman R, Reiter Y, Mendelson E, Livneh Z, Freedman LS, and Lustig Y
- Abstract
Background: An Israeli national taskforce performed a multi-center clinical and analytical validation of seven serology assays to determine their utility and limitations for SARS-CoV-2 diagnosis., Methods: Serology assays from Roche, Abbott, Diasorin, BioMerieux, Beckman-Coulter, Siemens, and an in-house RBD ELISA were included. Negative samples from 2391 individuals representative of the Israeli population, and 698 SARS-CoV-2 PCR positive patients, collected between March and May 2020, were analyzed., Findings: Immunoassays sensitivities between 81.5%-89.4% and specificities between 97.7%-100% resulted in a profound impact on the expected Positive Predictive Value (PPV) in low (<15%) prevalence scenarios. No meaningful increase was detected in the false positive rate in children compared to adults. A positive correlation between disease severity and antibody titers, and no decrease in antibody titers in the first 8 weeks after PCR positivity was observed. We identified a subgroup of symptomatic SARS-CoV-2 positive patients (~5% of patients), who remained seronegative across a wide range of antigens, isotypes, and technologies., Interpretation: The commercially available automated immunoassays exhibit significant differences in performance and expected PPV in low prevalence scenarios. The low false-positivity rate in under 20's suggests that cross-reactive immunity from previous CoV strains is unlikely to explain the milder disease course in children. Finding no decrease in antibody titers in the first 8 weeks is in contrast to some reports of short half-life for SARS-CoV-2 antibodies. The ~5% who were seronegative non-responders, using multiple assays in a population-wide manner, represents the proportion of patients that may be at risk for re-infection., Funding: Israel Ministry of Health., Competing Interests: YL is supported by the Nehemia Rubin Excellence in Biomedical Research – The TELEM Program of Chaim Sheba Medical Center. All other authors have nothing to declare., (© 2020 The Authors.)
- Published
- 2020
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36. ARID1A spatially partitions interphase chromosomes.
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Wu S, Fatkhutdinov N, Rosin L, Luppino JM, Iwasaki O, Tanizawa H, Tang HY, Kossenkov AV, Gardini A, Noma KI, Speicher DW, Joyce EF, and Zhang R
- Subjects
- Adenosine Triphosphatases chemistry, Binding Sites, Cell Line, Tumor, Chromatin chemistry, Cluster Analysis, DNA-Binding Proteins chemistry, DNA-Binding Proteins genetics, Enhancer Elements, Genetic, Gene Expression Profiling, Humans, Multiprotein Complexes chemistry, Promoter Regions, Genetic, Protein Binding, RNA-Seq, Serine Endopeptidases chemistry, Transcription Factors genetics, Chromosomes ultrastructure, DNA-Binding Proteins physiology, Interphase genetics, Transcription Factors physiology
- Abstract
ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in higher-order spatial chromosome partitioning and genome organization is unknown. Here, we show that ARID1A spatially partitions interphase chromosomes and regulates higher-order genome organization. The SWI/SNF complex interacts with condensin II, and they display significant colocalizations at enhancers. ARID1A knockout drives the redistribution of condensin II preferentially at enhancers, which positively correlates with changes in transcription. ARID1A and condensin II contribute to transcriptionally inactive B-compartment formation, while ARID1A weakens the border strength of topologically associated domains. Condensin II redistribution induced by ARID1A knockout positively correlates with chromosome sizes, which negatively correlates with interchromosomal interactions. ARID1A loss increases the trans interactions of small chromosomes, which was validated by three-dimensional interphase chromosome painting. These results demonstrate that ARID1A is important for large-scale genome folding and spatially partitions interphase chromosomes.
- Published
- 2019
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37. Co-evolving CENP-A and CAL1 Domains Mediate Centromeric CENP-A Deposition across Drosophila Species.
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Rosin L and Mellone BG
- Subjects
- Animals, Centromere Protein A, Chromatin metabolism, Chromosome Segregation physiology, Mitosis physiology, Centromere metabolism, DNA-Binding Proteins metabolism, Drosophila metabolism, Drosophila Proteins metabolism, Histones metabolism
- Abstract
Centromeres mediate the conserved process of chromosome segregation, yet centromeric DNA and the centromeric histone, CENP-A, are rapidly evolving. The rapid evolution of Drosophila CENP-A loop 1 (L1) is thought to modulate the DNA-binding preferences of CENP-A to counteract centromere drive, the preferential transmission of chromosomes with expanded centromeric satellites. Consistent with this model, CENP-A from Drosophila bipectinata (bip) cannot localize to Drosophila melanogaster (mel) centromeres. We show that this result is due to the inability of the mel CENP-A chaperone, CAL1, to deposit bip CENP-A into chromatin. Co-expression of bip CENP-A and bip CAL1 in mel cells restores centromeric localization, and similar findings apply to other Drosophila species. We identify two co-evolving regions, CENP-A L1 and the CAL1 N terminus, as critical for lineage-specific CENP-A incorporation. Collectively, our data show that the rapid evolution of L1 modulates CAL1-mediated CENP-A assembly, suggesting an alternative mechanism for the suppression of centromere drive., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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38. EARLY POSTOPERATIVE COMPLICATIONS IN ROUX-EN-Y GASTRIC BYPASS.
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Stoll A, Rosin L, Dias MF, Marquiotti B, Gugelmin G, and Stoll GF
- Abstract
Background: Roux-en-Y gastric bypass is one of the most common bariatric surgery and leads to considerable weight loss in the first months., Aim: To quantify the main early postoperative complications in patients submitted to the gastric bypass., Method: Observational retrospective cohort. Data of 1051 patients with class II obesity associated with comorbidities or class III obesity submitted to the gastric bypass with 30 days of follow-up starting from the date of the surgery., Results: The age average was 36 years with a predominance of females (81.1%). The mean preoperative body mass index was 43 kg/m². The major complication was fistula (2.3%), followed by intestinal obstruction (0.5%) and pulmonary embolism (0.5%). Death occurred in 0.6% of the cases., Conclusion: In the period of 30 days after surgery the overall complication rate was 3.8%; reoperation was necessary in 2.6% and death occurred in 0.6%. Fistula was the main complication and the leading cause of hospitalization in intensive care unit, reoperation and death., Competing Interests: none
- Published
- 2016
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39. Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription.
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Chen CC, Bowers S, Lipinszki Z, Palladino J, Trusiak S, Bettini E, Rosin L, Przewloka MR, Glover DM, O'Neill RJ, and Mellone BG
- Subjects
- Animals, Centromere Protein A, Chromatin Assembly and Disassembly physiology, Mitosis physiology, Carrier Proteins metabolism, Centromere metabolism, Chromatin metabolism, DNA-Binding Proteins metabolism, Drosophila Proteins metabolism, Drosophila melanogaster metabolism, Histones metabolism
- Abstract
Centromeres are essential chromosomal structures that mediate accurate chromosome segregation during cell division. Centromeres are specified epigenetically by the heritable incorporation of the centromeric histone H3 variant CENP-A. While many of the primary factors that mediate centromeric deposition of CENP-A are known, the chromatin and DNA requirements of this process have remained elusive. Here, we uncover a role for transcription in Drosophila CENP-A deposition. Using an inducible ectopic centromere system that uncouples CENP-A deposition from endogenous centromere function and cell-cycle progression, we demonstrate that CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA. This transcription depends on the CAL1 binding partner FACT, but not on CENP-A incorporation. Our work establishes RNAPII passage as a key step in chaperone-mediated CENP-A chromatin establishment and propagation., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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40. Management of patients with atrial fibrillation by primary-care physicians in Germany: 1-year results of the ATRIUM registry.
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Kirchhof P, Schmalowsky J, Pittrow D, Rosin L, Kirch W, Wegscheider K, and Meinertz T
- Subjects
- Aged, Aged, 80 and over, Anticoagulants therapeutic use, Atrial Fibrillation complications, Cohort Studies, Electrocardiography, Female, Follow-Up Studies, Germany, Humans, Male, Middle Aged, Physicians, Primary Care, Prognosis, Prospective Studies, Registries, Risk Factors, Treatment Outcome, Atrial Fibrillation drug therapy, Hospitalization statistics & numerical data
- Abstract
Background: Patients with atrial fibrillation (AF) in Germany are often managed jointly by primary-care physicians in cooperation with cardiologists. We aimed to investigate the management and 1-year outcomes of AF patients in this setting., Hypothesis: We set out to describe the current management of AF patients in primary care settings in Germany., Methods: Observational registry with 1-year follow-up, performed by a representative, randomly selected sample of 781 primary-care physicians in Germany., Results: Of 3781 patients with electrocardiographically documented AF, 3163 patients (age 71.9 ± 9.2 years, 57.9% males) were followed for 1 year; 28.4% had paroxysmal, 27.0% persistent, and 43.3% permanent AF. Comorbid conditions were common (mean CHA2 DS2-VASc score 3. 8 ± 1.7). Rhythm-control therapy was used in 16.4%. Although oral anticoagulation was often used (82.7% at baseline), stroke rate during follow-up was high (2.7% stroke, 3.0% transient ischemic attack). Despite a long duration of AF (mean duration 61 months at enrollment), 18.5% of patients were hospitalized during the 1-year follow-up., Conclusions: In this unselected group of patients with long-standing AF managed in primary care, hospitalizations and cardiovascular complications including strokes are frequent, illustrating the need to improve management of AF patients., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2014
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41. Cervical Pap screening among Israeli women, 2005-2010.
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Bassal R, Schejter E, Bachar R, Shapira H, Sandbank J, Supino Rosin L, Schvimer M, Cohen D, and Keinan-Boker L
- Subjects
- Adenocarcinoma epidemiology, Adult, Carcinoma, Squamous Cell epidemiology, Female, Humans, Israel epidemiology, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Retrospective Studies, Uterine Cervical Dysplasia epidemiology, Uterine Cervical Neoplasms epidemiology, Adenocarcinoma pathology, Carcinoma, Squamous Cell pathology, Papanicolaou Test statistics & numerical data, Uterine Cervical Dysplasia pathology, Uterine Cervical Neoplasms pathology, Vaginal Smears statistics & numerical data
- Abstract
Purpose: This study describes the distribution and the trends of cervical abnormalities in Israel, based on Pap smear results., Methods: A retrospective analysis of cervical smears received by the Central Pathology Laboratory of Maccabi Healthcare Services between January 2005 and December 2010., Results: In total, 711,541 Pap smears were screened in the study period. Cytological abnormalities were observed in 4.78% of the total smears screened. An increase was observed in the rate of positive results from 2.63% in 2005 to 6.78% in 2010 (p = 0.0026). The cervical abnormalities in the study period distributed as follows: atypical squamous cell (ASC)-2.72%, low-grade squamous intraepithelial lesion (LSIL)-1.54%, high-grade squamous intraepithelial lesion (HSIL)-0.34%, squamous cell carcinoma-0.01%, atypical glandular cells (AGC)-0.10%, adenocarcinoma in situ (AIS)-0.06% and invasive adenocarcinoma-0.01%. The increase was statistically significant for ASC (p = 0.0028), LSIL (p = 0.0069) and for HSIL (p = 0.0260). The mean ages at diagnosis of women with ASCUS, LSIL, HSIL, squamous cell carcinoma, AGC, AIS and adenocarcinoma were 37.8, 33.2, 38.6, 55.4, 41.1, 49.9 and 57.1 years, respectively., Conclusions: The increase in the rate of squamous cell abnormalities demonstrated in this study emphasizes the need of implementing an education and a screening program among Israeli women. HPV vaccine, sexual behavior, cytology performance and HPV test are primary and secondary prevention tools which may reduce morbidity and mortality in the future. In addition, based on the age at diagnosis of the different pathologies, the age group in which Pap test is performed in Israel should be expanded from 35-54 to 25-65 years.
- Published
- 2014
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42. Improved detection of paroxysmal atrial fibrillation utilizing a software-assisted electrocardiogram approach.
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Schaefer JR, Leussler D, Rosin L, Pittrow D, and Hepp T
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Reproducibility of Results, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Electrocardiography methods, Stroke diagnosis, Stroke physiopathology
- Abstract
Background: Automated complexity-based statistical stroke risk analysis (SRA) of electrocardiogram (ECG) recordings can be used to estimate the risk of paroxysmal atrial fibrillation (pAF). We investigated whether this method could improve the reliability of detection of patients at risk for pAF., Methods and Results: Data from 12-lead ECGs, 24-h Holter ECGs, and SRA based on separate 1-hour Holter ECG snips were collected from three groups: 70 patients with a history of pAF but who showed no AF episode in the 12-lead ECG at study entry; 19 patients with chronic AF (at study entry); and 100 young healthy individuals. AF episodes were detected by Holter ECG in 19 of the 70 non-chronic AF patients (27.1% overall, 18.6% in the first hour), and 37 of these 70 patients were classified as at risk for pAF by SRA (representing a sensitivity of 52.9% based on the first hour of analyzed recording). Fifty-four of the 70 patients also showed a sinus rhythm in the first hour. SRA detected pAF risk in 23 of these 54 patients (representing a sensitivity of 42.6%). The Holter data showed at least 1 AF episode and at least 1 hour of sinus rhythm in nine of the patients with pAF. For these patients, SRA classified 77.8% as being at risk in the first hour after the end of the AF episode, and 71.4% and 42.9% as being at risk in the second and third hours, respectively. SRA detected almost all cardiologist-confirmed AF episodes that had been recorded in 1-hour ECG snips (sensitivity, 99.2%; specificity, 99.2%)., Conclusions: This outpatient study confirms previous findings that routine use of SRA could improve AF detection rates and thus may shorten the time between AF onset and initiation of prevention measures for patients at high risk for stroke.
- Published
- 2014
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43. Improved detection of silent atrial fibrillation using 72-hour Holter ECG in patients with ischemic stroke: a prospective multicenter cohort study.
- Author
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Grond M, Jauss M, Hamann G, Stark E, Veltkamp R, Nabavi D, Horn M, Weimar C, Köhrmann M, Wachter R, Rosin L, and Kirchhof P
- Subjects
- Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation complications, Atrial Fibrillation physiopathology, Brain Ischemia physiopathology, Cohort Studies, Female, Humans, Ischemic Attack, Transient physiopathology, Male, Middle Aged, Prospective Studies, Stroke physiopathology, Time Factors, Atrial Fibrillation diagnosis, Brain Ischemia complications, Electrocardiography, Ambulatory methods, Ischemic Attack, Transient complications, Stroke complications
- Abstract
Background and Purpose: Adequate diagnosis of atrial fibrillation (AF), including paroxysmal AF, is an important part of stroke workup. Prolonged ECG monitoring may improve the detection of paroxysmal, previously undiagnosed AF (unknown AF). Therefore, we evaluated systematic 72-hour Holter ECG monitoring to detect unknown AF for the workup of patients with stroke., Methods: Unselected survivors of a stroke or transient ischemic attack (TIA) without known AF were enrolled in a prospective, multicenter cohort study of 72-hour Holter ECG monitoring in 9 German secondary and tertiary stroke centers between May 2010 and January 2011. In addition to standardized workup of stroke pathogenesis according to the German Stroke Unit protocol, all patients underwent 72-hour Holter ECG monitoring directly after admission. All ECGs were centrally analyzed by 2 independent observers. We determined the proportion of unknown AF and compared the detection rates of 72- and 24-hour monitoring., Results: A total of 1135 patients were enrolled (mean age, 67 years [SD, 13.1 years], 45% women, 29% TIA). Unknown AF was detected in 49 out of 1135 patients (4.3%, [95% confidence interval, 3.4-5.2%]) by 72-hour ECG monitoring. Unknown AF was diagnosed in 29 patients (2.6%) within the first 24 hours of ECG monitoring, and in 20 more patients only by 72 hours of ECG monitoring. The number needed to screen by 72-hour ECG was 55 patients (95% confidence interval [35-123]) for each additional AF diagnosis. Patients with unknown AF were significantly older and had more often a history of previous stroke. Patients with unknown AF were equally distributed within categories of pathogenesis according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification., Conclusions: In unselected survivors of stroke or TIA, 72-hour ECG monitoring is feasible and improves the detection rate of silent paroxysmal AF.
- Published
- 2013
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44. Vascular risk prediction in ischemic stroke patients undergoing in-patient rehabilitation - insights from the investigation of patients with ischemic stroke in neurologic rehabilitation (INSIGHT) registry.
- Author
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Weimar C, Siebler M, Brandt T, Römer D, Rosin L, Bramlage P, and Sander D
- Subjects
- Aged, Female, Humans, Male, Predictive Value of Tests, Recurrence, Registries, Risk Factors, Cardiovascular Diseases complications, Cardiovascular Diseases epidemiology, Stroke complications, Stroke Rehabilitation
- Abstract
Background: In-patient rehabilitation following ischemic stroke offers a unique opportunity for risk factor and lifestyle modification. Quantification of risk in this setting may help to tailor therapy, increase physician awareness and patient compliance and thus to reduce recurrent vascular events., Aims: To validate the predictive value of established secondary stroke risk scores., Methods: One thousand one hundred sixty-three patients undergoing in-patient rehabilitation following recent ischemic stroke in 15 German neurologic rehabilitation centers were included 0·9 ± 0·5 months after the index event. Outcome information was available for 846 participants (72·7%) after a mean follow-up of 13 ± 2·3 months., Results: Patients' mean age was 66·3 ± 12·3 years and 42·5% were women. The National Institutes of Health Stroke Scale (mean 4·0 ± 3·9), modified Rankin scale (median 2, range 0-5), and Barthel Index (median 90, range 0-100) indicated good functional status. A recurrent fatal or nonfatal stroke during follow-up occurred in 6·7% and combined vascular events (stroke, myocardial infarction, vascular death) in 10·9%. The predictive accuracy for recurrent stroke was slightly higher on the Essen Stroke Risk Score than on the Stroke Prognostis Instrument II (area under the curve 0·62 vs. 0·56), while both scores had a similar predictive accuracy for combined vascular events., Conclusions: Risk stratification on the Essen Stroke Risk Score and Stroke Prognostis Instrument II provides a moderate accuracy for the prediction of recurrent stroke and vascular events in patients undergoing neurologic in-patient rehabilitation. Although individual risk prediction may remain imprecise, the use of these scores should be encouraged., (© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.)
- Published
- 2013
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45. Stepwise evolution of essential centromere function in a Drosophila neogene.
- Author
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Ross BD, Rosin L, Thomae AW, Hiatt MA, Vermaak D, de la Cruz AF, Imhof A, Mellone BG, and Malik HS
- Subjects
- Amino Acid Sequence, Animals, Centromere genetics, Gene Duplication, Molecular Sequence Data, Centromere physiology, Chromosomal Proteins, Non-Histone genetics, Drosophila genetics, Drosophila Proteins genetics, Evolution, Molecular, Genes, Insect physiology
- Abstract
Evolutionarily young genes that serve essential functions represent a paradox; they must perform a function that either was not required until after their birth or was redundant with another gene. How young genes rapidly acquire essential function is largely unknown. We traced the evolutionary steps by which the Drosophila gene Umbrea acquired an essential role in chromosome segregation in D. melanogaster since the gene's origin less than 15 million years ago. Umbrea neofunctionalization occurred via loss of an ancestral heterochromatin-localizing domain, followed by alterations that rewired its protein interaction network and led to species-specific centromere localization. Our evolutionary cell biology approach provides temporal and mechanistic detail about how young genes gain essential function. Such innovations may constantly alter the repertoire of centromeric proteins in eukaryotes.
- Published
- 2013
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46. Management of atrial fibrillation by primary care physicians in Germany: baseline results of the ATRIUM registry.
- Author
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Meinertz T, Kirch W, Rosin L, Pittrow D, Willich SN, and Kirchhof P
- Subjects
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Chi-Square Distribution, Female, Germany, Guideline Adherence, Health Care Surveys, Hospitalization, Humans, Male, Middle Aged, Practice Guidelines as Topic, Prospective Studies, Quality of Life, Registries, Thromboembolism etiology, Time Factors, Treatment Outcome, Anti-Arrhythmia Agents therapeutic use, Atrial Fibrillation therapy, Cardiac Pacing, Artificial statistics & numerical data, Catheter Ablation statistics & numerical data, Electric Countershock statistics & numerical data, Fibrinolytic Agents therapeutic use, Physicians, Primary Care statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data, Thromboembolism prevention & control
- Abstract
Background: In contrast to surveys in cardiologist settings, presentation and management of atrial fibrillation (AF) in primary care patients is less well studied., Methods and Results: The prospective ATRIUM (Outpatient Registry Upon Morbidity of Atrial Fibrillation) collected data from patients with AF seen by 730 physicians representing a random sample of all primary care physicians in Germany. ATRIUM enrolled 3,667 patients (mean age, 72 ± 9 years; 58% male, mean CHADS(2) score 2.2 ± 1.3), 994 (27.1%) with paroxysmal, 944 (25.7%) with persistent or long-standing persistent and 1,525 (41.6%) with permanent AF (no AF type was specified in 204 patients). Mean duration since initial diagnosis of AF was 61 ± 66 months (median 42, interquartile range 14-88). Reported symptoms included palpitations (43%), shortness of breath (49%), fatigue (49%), dizziness (37%) and angina (20%). Most common concomitant conditions were hypertension (84%), heart failure (43%), coronary artery disease (345%), diabetes (35%) and chronic kidney disease (20%). Prior myocardial infarction was present in 11% of patients, prior stroke in 10% and prior transient ischemic attack in 10%. Antithrombotic medication was used by 93% of the patients (oral anticoagulants, 83%). Rate control therapy was reported in 75% and rhythm control therapy in 33%, often added to rate control. Drugs for rhythm and rate control included ß-blockers (75%), calcium antagonists (15%), digitalis (29%), sodium channel blockers of type IA (quinidine, 1.0%) or IC (flecainide or propafenone, 5%), and potassium channel blockers including amiodarone (11%). In the year prior to enrollment, 46% of the patients had been cardioverted (23% by drugs, 22% electrically), catheter ablation had been performed in 5%, and 10% received a pacemaker or defibrillator. A high proportion (44%) of the patients were hospitalized in the year prior to enrollment., Conclusions: Patients with AF managed in primary care often receive guideline-conforming therapy including antithrombotic therapy, rate control and rhythm control (numbers given above). Despite this apparent adherence, almost half of the patients were hospitalized in the year prior to enrollment, suggesting that the therapies applied do not stabilize patients sufficiently to keep them out of hospital.
- Published
- 2011
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47. Blood pressure management in a cohort of hypertensive patients in Germany treated by cardiologists.
- Author
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Thoenes M, Tebbe U, Rosin L, Paar WD, Bramlage P, Kirch W, and Böhm M
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Cardiology, Cardiovascular Diseases complications, Cardiovascular Diseases drug therapy, Cardiovascular Diseases physiopathology, Cohort Studies, Diabetes Complications drug therapy, Diabetes Complications physiopathology, Drug Therapy, Combination, Female, Germany, Humans, Male, Middle Aged, Antihypertensive Agents therapeutic use, Blood Pressure drug effects, Hypertension drug therapy
- Abstract
Background: In Germany, an estimated 20-25 million patients suffer from hypertension. Blood pressure control rates are, however, lower than in many other European countries and the USA. The present analysis reports blood pressure treatment and control rates in Germany in patients with hypertension treated by cardiologists., Methods: The present analysis reports data from a German subgroup analysis of a large, multinational, observational survey i-SEARCH that recruited patients in 2005/2006. It reports blood pressure readings, drug utilization and control rates in cardiology practice., Results: A total of 4,982 patients were documented at 417 sites. Mean systolic/diastolic blood pressure (SBP/DBP) was 152 ± 19.5/88.4 ± 11.5 mmHg. SBP was 1.3 mmHg higher in men than in women (p = 0.021). The majority of patients had an SBP between 141 and 160 mmHg and 31.4% of patients had normal SBP. Overall blood pressure control rate was only 11.6% [95% CI 10.7-12.6] in treated patients. It was different in men [10.2%; 95% CI 9.0-11.6] than in women [8.1%; 95% CI 7.1-9.4; p = 0.008] and higher in patients without diabetes [12.7%; 95% CI 11.6-14.0] than in those with diabetes [4.3%; 95% CI 3.4-5.4; p < 0.0001]. One-third of patients received either monotherapy or dual therapy, or three and more drugs, respectively; 42.2% of patients received guideline-recommended dual combination therapy. A combination of beta-blockers + ACE inhibitors was most frequently prescribed (30.8%)., Conclusions: Our data indicate a low level of blood pressure control, especially in patients at an increased risk for cardiovascular events, such as those with diabetes or cardiovascular comorbidities. Major efforts are required to improve hypertension management as recommend by current treatment guidelines.
- Published
- 2011
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48. Presentation of atrial fibrillation and its management by cardiologists in the ambulatory and hospital setting: MOVE cross-sectional study.
- Author
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Bonnemeier H, Bosch RF, Kohlhaussen A, Rosin L, Willich SN, Pittrow D, Kirch W, and Move Study Group
- Subjects
- Aged, Aged, 80 and over, Atrial Fibrillation complications, Cardiology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Thromboembolism etiology, Thromboembolism prevention & control, Ambulatory Care, Atrial Fibrillation therapy, Hospitalization, Hospitals, Public
- Abstract
Objective: The aim of the study was to collect comprehensive data on atrial fibrillation (AF) in ambulatory and hospital-based management in Germany., Methods: Consecutive patients with ECG-confirmed AF in the previous 12 months were documented in a non-interventional study in 638 physician offices (78.0%) or hospitals (12.7%)., Results: Of the 3354 patients (mean age 68.9 ± 10.1 years; CHADS(2) score 1.9 ± 1.3), a total of 1136 (33.9%) had paroxysmal, 899 (26.8%) persistent, 1295 (38.6%) permanent and 24 (0.7%) unspecified AF. In the 12 months prior to documentation, pharmacological conversion was attempted in 18.2%, electric cardioversion in 17.5%, the combination of both in 31.2%, and catheter ablation of AF in 5.5%. Only 41.4% of patients met the definition of stable disease (having neither AF related intervention nor change in antiarrhythmic therapy in the previous 12 months). As treatment strategy, physicians stated rate control in 64%, rhythm control in 8%, and both in 19% (not reported: 8%). Patients received antiarrhythmic drugs of class IA in 1.3%, IC in 13.8%, II in 78.1%, III in 17.9%, IV in 9.7% and digitalis in 26.7%. Drugs for thromboembolic prevention (oral anticoagulants and/or antithrombotics) were administered in 81.5%. Hospitalisations for AF or associated diseases in the previous 12 months were reported in 34.2%. Possible limitations include the open, observational design, selection of physicians with particular interest in the field and selection of patients (i.e. underrepresentation of critically ill individuals)., Conclusions: While treatment rates with regards to the prevention of thromboembolic events were among the highest reported to date, the low proportion of stable patients and in particular, the high hospitalisation rate hint at difficulties in the management of patients with AF in clinical practice.
- Published
- 2011
- Full Text
- View/download PDF
49. [Health-related quality of life of patients with atrial fibrillation managed by cardiologists: MOVE study].
- Author
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Kirch W, Pittrow D, Bosch RF, Kohlhaussen A, Willich SN, Rosin L, and Bonnemeier H
- Subjects
- Aged, Aged, 80 and over, Anti-Arrhythmia Agents adverse effects, Anti-Arrhythmia Agents therapeutic use, Anticoagulants therapeutic use, Atrial Fibrillation diagnosis, Atrial Fibrillation drug therapy, Atrial Fibrillation epidemiology, Catheter Ablation statistics & numerical data, Cohort Studies, Cross-Sectional Studies, Electric Countershock statistics & numerical data, Emergency Service, Hospital statistics & numerical data, Female, Germany, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Pain Measurement, Primary Health Care statistics & numerical data, Prospective Studies, Utilization Review statistics & numerical data, Atrial Fibrillation psychology, Quality of Life psychology
- Abstract
Background and Objective: In daily clinical practise, there is a lack of representative and robust data on the health-related quality of life (QoL) of patients with atrial fibrillation (AF)., Participants and Method: In the non-interventional MOVE study, 638 physicians (predominantly cardiologists) in ambulatory care (78.0% of all centres) or hospital-based (12.7%), documented prospectively and retrospectively data from 3354 consecutive patients with ECG-confirmed AF in the previous 12 months (mean age 68.9 +/- 10.1 years; 62.4% males, mean CHADS (2) score 1.9 +/- 1.3). 1136 (33.9%) had paroxysmal, 899 (26.8%) persistent and 1295 (38.6%) permanent AF., Results: Symptoms within the previous 4 weeks were present in 89.9% of the cases and 43.1% of the patients reported palpitations in the range from sometimes to very frequently. As treatment aim, physicians reported rate control in 64%, rhythm control in 8%, and both in 19% of the cases (not stated: 8%). In the University of Toronto Atrial Fibrillation Severity Scale (AFSS), emergency room attendance or hospitalizations for AF or associated diseases in the previous 12 months were reported in 24.2% or 30.8%, respectively. Rhythm control was associated with higher emergency room admittance or hospitalization rates, respectively. The EQ-5D index (0.94 points) was near the maximum of 1; thus this index does not appear to reflect QoL of AF patients adequately. Analyses of the Visual Analogue Scale (VAS) of the EuroQol (EQ-5D), and the assessment scale or specific questions of AFSS, respectively, indicated an intermediate QoL or disease burden, respectively. No or only small differences were documented between subgroups with different AF types, or subgroups treated according to different aims., Conclusion: The great majority of AF patients had one or more recent AF symptoms, and their overall QoL was limited. In daily practise, rate control is not inferior to rhythm control in AF patients with respect to QoL., (Georg Thieme Verlag KG Stuttgart New York.)
- Published
- 2010
- Full Text
- View/download PDF
50. Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity.
- Author
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Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, and Neumann D
- Subjects
- Animals, Benzoquinones, Biological Transport, COS Cells, Chromatography, Chromatography, Gel, Cysteine Proteinase Inhibitors pharmacology, DNA, Complementary metabolism, ErbB Receptors metabolism, Golgi Apparatus metabolism, HSP70 Heat-Shock Proteins metabolism, Hexosaminidases metabolism, Lactams, Macrocyclic, Membrane Glycoproteins chemistry, Membrane Proteins metabolism, Mutation, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase metabolism, Plasmids metabolism, Precipitin Tests, Protein Transport, Receptors, Erythropoietin metabolism, Streptomyces metabolism, Time Factors, Transfection, Viral Envelope Proteins chemistry, HSP70 Heat-Shock Proteins chemistry, HSP90 Heat-Shock Proteins metabolism, Membrane Proteins chemistry, Quinones pharmacology
- Abstract
Geldanamycin, an ansamycin antibiotic that specifically inhibits heat-shock protein-90 (HSP90) and its endoplasmic reticulum homologue, glucose-regulated protein-94 (GRP94), accelerates the degradation of selected cellular proteins. We showed previously that geldanamycin inhibits maturation and transport of the epidermal growth factor receptor in addition to accelerating its degradation (Supino-Rosin, L., Yoshimura, A., Yarden, Y., Elazar, Z., and Neumann, D. (2000) J. Biol. Chem. 275, 21850-21855). Here we demonstrate that the additional activities of geldanamycin on intracellular transport and protein maturation are related to its supply source. By combining chemical separation of Streptomyces hygroscopicus var. geldanus extracts and biological screens, we show that the geldanamycin-associated effects on intracellular transport and protein maturation are not mediated by geldanamycin itself but are due to the presence of an additional component(s). Chromatography of S. hygroscopicus var. geldanus extracts on a silica-gel column allowed separation between the inhibition of intracellular trafficking and geldanamycin-mediated degradation. One fraction that was devoid of geldanamycin blocked secretion of a soluble form of the erythropoietin receptor, retarded maturation of the epidermal growth factor receptor without enhancing its degradation, and blocked anterograde transport of a temperature-sensitive mutant of the vesicular stomatitis virus G protein (VSVGtsO45) from the early Golgi cisternae. This fraction was enriched (>95%) in 17-demethylgeldanamycin. However, as synthetically derived 17-demethylgeldanamycin did not inhibit intracellular trafficking, we concluded that 17-demethylgeldanamycin is not the active component. We thus propose that a compound(s) that co-purifies with benzoquinone ansamycins inhibits intracellular transport. Taken together, our data demonstrate that the inhibitory effects on protein maturation and intracellular trafficking, previously attributed to geldanamycin, are mediated by another distinct moiety.
- Published
- 2004
- Full Text
- View/download PDF
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