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15 results on '"Rosa, Rafael L."'

1. Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV

Author

Tatara, Juliana M., Rosa, Rafael L., Varela, Ana Paula M., Teixeira, Tais F., Sesterheim, Patrícia, Gris, Anderson, Driemeier, David, Moraes, Amanda N. S., Berger, Markus, Peña, Ramon D., Roehe, Paulo M., Souza, Diogo O. G., Guimarães, Jorge A., Campos, Alexandre R., Santi, Lucélia, and Beys-da-Silva, Walter O.

Published
2023
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5. The role of glial cells in Zika virus‐induced neurodegeneration

Author

Quincozes‐Santos, André, primary, Bobermin, Larissa Daniele, additional, Costa, Naithan Ludian Fernandes, additional, Thomaz, Natalie K., additional, Almeida, Rômulo Rodrigo de Souza, additional, Beys‐da‐Silva, Walter O., additional, Santi, Lucélia, additional, Rosa, Rafael L., additional, Capra, Daniela, additional, Coelho‐Aguiar, Juliana M., additional, DosSantos, Marcos Fabio, additional, Heringer, Manoela, additional, Cirne‐Lima, Elizabeth O., additional, Guimarães, Jorge Almeida, additional, Schuler‐Faccini, Lavínia, additional, Gonçalves, Carlos‐Alberto, additional, Moura‐Neto, Vivaldo, additional, and Souza, Diogo Onofre, additional

Published
2023
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8. Zika Virus Infection Associated with Autism Spectrum Disorder: A Case Report

Author

Santi, Lucélia, primary, Riesgo, Rudimar S., additional, Quincozes-Santos, André, additional, Schuler-Faccini, Lavínia, additional, Tureta, Emanuela F., additional, Rosa, Rafael L., additional, Berger, Markus, additional, Oliveira, Avessandra C.C., additional, Beltrão-Braga, Patrícia C.B., additional, Souza, Diogo O., additional, Guimarães, Jorge A., additional, and Beys-da-Silva, Walter O., additional

Published
2021
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12. Association between molecular markers of COVID‐19 and Alzheimer's disease.

Author

Quincozes‐Santos, André, Rosa, Rafael L. da, Bobermin, Larissa D., Tureta, Emanuela F., Santi, Lucélia, and Beys‐da‐Silva, Walter O.

Subjects
ALZHEIMER'S disease, ENCEPHALITIS, METABOLIC disorders, MOLECULAR association, COVID-19, INSULIN-like growth factor-binding proteins, MEDICAL personnel
Abstract

Although the understanding of the etiology and pathogenesis of AD has been expanded in the last years, the potential association between COVID-19 and AD remains unclear.3 Importantly, some pathomechanisms related to AD are shared with COVID-19. In line with this, SARS-CoV-2 may activate glial cells, thus potentially triggering chronic neuroinflammation and neurodegeneration.3 Of note, the inflammatory response may lead to the neuronal death observed in postmortem samples of patients with COVID-19,4 as well as SARS-CoV-2 neuroinvasion may trigger neuropathological changes.5 Alzheimer's disease (AD) is the most common age-related neurodegenerative disease. Keywords: Infection; Inflammation; Immune responses; SARS coronavirus; Virus classification EN Infection Inflammation Immune responses SARS coronavirus Virus classification 833 835 3 01/21/22 20220301 NES 220301 The COVID-19 pandemic has represented an exceptional health challenge as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has acute and chronic consequences. [Extracted from the article]

Published
2022
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13. Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases

Author

Beys-da-Silva, Walter O., primary, Rosa, Rafael L., additional, Santi, Lucélia, additional, Berger, Markus, additional, Park, Sung Kyu, additional, Campos, Alexandre R., additional, Terraciano, Paula, additional, Varela, Ana Paula M., additional, Teixeira, Thais F., additional, Roehe, Paulo M., additional, Quincozes-Santos, André, additional, Yates, John R., additional, Souza, Diogo O., additional, Cirne-Lima, Elizabeth O., additional, and Guimarães, Jorge A., additional

Published
2018
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14. Secretomic analysis of Beauveria bassiana related to cattle tick, Rhipicephalus microplus, infection

Author

Santi, Lucélia, primary, Coutinho-Rodrigues, Caio J. B., additional, Berger, Markus, additional, Klein, Lisete A. S., additional, De Souza, Eduardo M., additional, Rosa, Rafael L., additional, Guimarães, Jorge A., additional, Yates, John R., additional, Perinotto, Wendell M. S., additional, Bittencourt, Vânia R. E. P., additional, and Beys-da-Silva, Walter O., additional

Published
2018
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15. Proteomics of Rat Lungs Infected by Cryptococcus gattiiReveals a Potential Warburg-like Effect

Author

Rosa, Rafael L., Berger, Markus, Santi, Lucélia, Driemeier, David, Barros Terraciano, Paula, Campos, Alexandre R., Guimarães, Jorge A., Vainstein, Marilene H., Yates, John R., and Beys-da-Silva, Walter O.

Abstract

Cryptococcus gattiiis the causative agent of cryptococcosis infection that can lead to pneumonia and meningitis in immunocompetent individuals. The molecular basis of the pathogenic process and impact on the host biochemistry are poorly understood and remain largely unknown. In this context, a comparative proteomic analysis was performed to investigate the response of the host during an infection caused by C. gattii. Lungs of experimentally infected rats were analyzed by shotgun proteomics to identify differentially expressed proteins induced by C. gattiiclinical strain. The proteomic results were characterized using bioinformatic tools, and subsequently, the molecular findings were validated in cell culture and lungs of infected animals. A dramatic change was observed in protein expression triggered by C. gattiiinfection, especially related to energy metabolism. The main pathways affected include aerobic glycolysis cycle, TCA cycle, and pyrimidine and purine metabolism. Analyses in human lung fibroblast cells confirmed the altered metabolic status found in infected lungs. Thus, it is clear that C. gattiiinfection triggers important changes in energy metabolism leading to the activation of glycolysis and lactate accumulation in lung cells, culminating in a cancerlike metabolic status known as the Warburg effect. The results presented here provide important insights to better understand C. gattiimolecular pathogenesis.

Published
2019
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