1,409 results on '"Roos, Yvo"'
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2. Advancements in diagnostic and interventional radiology for stroke treatment: the path from trial to bedside through the pre-MR CLEAN, MR CLEAN, and MR CLEAN II eras
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Samuels, Noor, van de Graaf, Rob A., Roos, Yvo B. W. M., Dippel, Diederik, and van der Lugt, Aad
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- 2024
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3. Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study
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van Voorst, Henk, Hoving, Jan W., Koopman, Miou S., Daems, Jasper D., Peerlings, Daan, Buskens, Erik, Lingsma, Hester F., Beenen, Ludo F. M., de Jong, Hugo W. A. M., Berkhemer, Olvert A., van Zwam, Wim H., Roos, Yvo B. W. E. M., van Walderveen, Marianne A. A., van den Wijngaard, Ido, Dippel, Diederik W. J., Yoo, Albert J., Campbell, Bruce C. V., Kunz, Wolfgang G., Emmer, Bart J., and Majoie, Charles B. L. M.
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- 2024
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4. Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomised controlled trial in the Netherlands
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van Oostenbrugge, Robert, van Zwam, Wim, Olthuis, Susanne, Pirson, Anne, Hinsenveld, Wouter, Goldhoorn, Robert-Jan, Staals, Julie, Dippel, Diederik, van der Lugt, Aad, van Es, Adriaan, Roozenbeek, Bob, van Doormaal, Pieter-Jan, Roos, Yvo, Majoie, Charles, Coutinho, Jonathan, Emmer, Bart, van der Worp, Bart, Lo, Rob, van Walderveen, Marianne, Wermer, Marieke, van Dijk, Ewoud, Jenniskens, Sjoerd, Boogaarts, Hieronymus, Uyttenboogaart, Maarten, Bokkers, Reinoud, Keizer, Koos, Gons, Rob, Yo, Lonneke, den Hertog, Heleen, van Hasselt, Boudewijn, Schonewille, Wouter, Vos, Jan-Albert, van Tuijl, Julia, Boukrab, Issam, Kortman, Hans, Hofmeijer, Jeannette, Martens, Jasper, van den Wijngaard, Ido, Boiten, Jelis, Lycklama à Nijeholt, Geert, Brouwers, Paul, Sturm, Emiel, Bulut, Tomas, de Laat, Karlijn, van Dijk, Lukas, Remmers, Michel, de Jong, Thijs, Rozeman, Anouk, Elgersma, Otto, Van der Veen, Bas, Sudiono, Davy, Mattle, Heinrich, Fiehler, Jens, van Kuijk, Sander, Nieboer, Daan, Lingsma, Hester, van Nuland, Rick, Roosendaal, Stefan, Krietemeijer, Menno, Postma, Alida, Van den Berg, René, Beenen, Ludo, Hammer, Sebastiaan, Meijer, Anton, van der Hoorn, Anouk, Yoo, Albert, Gerrits, Dick, Jansen, Ben, Truijman, Martine, Manschot, Sanne, Kerkhoff, Henk, Koudstaal, Peter, Chalos, Vicky, Berkhemer, Olvert, Versteeg, Adriaan, Wolff, Lennard, Su, Jiahang, van der Sluijs, Matthijs, van Voorst, Henk, Tolhuisen, Manon, ten Cate, Hugo, de Maat, Moniek, Donse-Donkel, Samantha, van Beusekom, Heleen, Taha, Aladdin, Barakzie, Aarazo, Treurniet, Kilian, van den Berg, Sophie, LeCouffe, Natalie, van de Graaf, Rob, de Ridder, Inger, Pinckaers, Florentina, Ceulemans, Angelique, Knapen, Robrecht, Robbe, Quirien, Sondag, Lotte, Kappelhof, Manon, Reinink, Rik, Silvis, Suzanne, Schreuder, Floris, Uniken Venema, Simone, van Meenen, Laura, Collette, Sabine, van Wijngaarden, Wilma, van der Steen, Wouter, Hoving, Jan, Verheesen, Sabrina, Sterrenberg, Martin, El Ghannouti, Naziha, Sprengers, Rita, van Ahee, Ayla, Zweedijk, Berber, Pellikaan, Wilma, Schonewille, Irati, Blauwendraat, Kitty, Drabbe, Yvonne, Kleine-Kathöfer, Anke, de Meris, Joke, Sandiman, Michelle, Dofferhoff-Vermeulen, Tamara, Simons, Michelle, Bongenaar, Hester, Smallegange, Maylee, van Loon, Anja, Kraus, Karin, Bos-Verheij, Erna, Santegoets, Ester, Kooij, Suze, Slotboom, Annemarie, Ponjee, Eva, Eilander, Rieke, Droste, Hanneke, van Veen, Esther, Visser, Rosalie, Lodico, Jasmijn, de Jong, Marieke, van der Minne, Friedus, Cleophas, Eefje, Muskens, Ernst, Nijst, Amy, Heiligers, Leontien, Martens, Yvonne, Slotboom, Miranda, Hintzen, Rogier, Jacobs, Bart, Huijberts, Ilse, Pinckaers, Florentina M E, Olthuis, Susanne G H, van Kuijk, Sander M J, Postma, Alida A, Boogaarts, Hieronymus D, Roos, Yvo B W E M, Majoie, Charles B L M, Dippel, Diederik W J, van Zwam, Wim H, and van Oostenbrugge, Robert J
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- 2024
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5. Perceived acceptable uncertainty regarding comparability of endovascular treatment alone versus intravenous thrombolysis plus endovascular treatment
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Kaesmacher, Johannes, Mujanovic, Adnan, Treurniet, Kilian, Kappelhof, Manon, Meinel, Thomas R, Yang, Pengfei, Liu, Jianmin, Zhang, Yongwei, Zi, Wenjie, Yang, Qingwu, Nogueira, Raul G, Kimura, Kazumi, Matsumaru, Yuji, Suzuki, Kentaro, Yan, Bernard, Mitchell, Peter J, Miao, Zhongrong, Roos, Yvo BWEM, Majoie, Charles BLM, Gralla, Jan, Saver, Jeffrey L, and Fischer, Urs
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Clinical Trials and Supportive Activities ,Clinical Research ,Humans ,Brain Ischemia ,Endovascular Procedures ,Fibrinolytic Agents ,Stroke ,Thrombectomy ,Thrombolytic Therapy ,Treatment Outcome ,Uncertainty ,thrombectomy ,thrombolysis ,stroke - Abstract
BackgroundMost trials comparing endovascular treatment (EVT) alone versus intravenous thrombolysis with alteplase (IVT) + EVT in directly admitted patients with a stroke are non-inferiority trials. However, the margin based on the level of uncertainty regarding non-inferiority of the experimental treatment that clinicians are willing to accept to incorporate EVT alone into clinical practice remains unknown.ObjectiveTo characterize what experienced stroke clinicians would consider an acceptable level of uncertainty for hypothetical decisions on whether to administer IVT or not before EVT in patients admitted directly to EVT-capable centers.MethodsA web-based, structured survey was distributed to a cross-section of 600 academic neurologists/neurointerventionalists. For this purpose, a response framework for a hypothetical trial comparing IVT+EVT (standard of care) with EVT alone (experimental arm) was designed. In this trial, a similar proportion of patients in each arm achieved functional independence at 90 days. Invited physicians were asked at what level of certainty they would feel comfortable skipping IVT in clinical practice, considering these hypothetical trial results.ResultsThere were 180 respondents (response rate: 30%) and 165 with complete answers. The median chosen acceptable uncertainty suggesting reasonable comparability between both treatments was an absolute difference in the rate of day 90 functional independence of 3% (mode 5%, IQR 1-5%), with higher chosen margins observed in interventionalists (aOR 2.20, 95% CI 1.06 to 4.67).ConclusionPhysicians would generally feel comfortable skipping IVT before EVT at different certainty thresholds. Most physicians would treat with EVT alone if randomized trial data suggested that the number of patients achieving functional independence at 90 days was similar between the two groups, and one could be sufficiently sure that no more than 3 out of 100 patients would not achieve functional independence at 90 days due to skipping IVT.
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- 2023
6. Association between coagulation activity and clinical and imaging outcomes in acute ischemic stroke patients - A sub-study of the MR CLEAN NO-IV trial
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Ceulemans, Angelique, Barakzie, Aarazo, Spronk, Henri M.H., de Maat, Moniek P.M., van Beusekom, Heleen M.M., Taha, Aladdin, Emmer, Bart J., Roos, Yvo B.W.E.M., Dippel, Diederik W.J., Majoie, Charles B.L.M., van Zwam, Wim H., ten Cate, Hugo, van Oostenbrugge, Robert J., and Nagy, Magdolna
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- 2025
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7. Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study
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Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan-Albert, van Doormaal, Pieter-Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama à Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., Schonewille, Wouter J., Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Compagne, Kars C.J., Kappelhof, Manon, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van der Lugt, Aad, Roos, Yvo B.W.E.M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., van Es, Adriaan C.G.M., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Boiten, Jelis, de Bruijn, Sebastiaan F., van Dijk, Lukas C., Bart van der Worp, H., Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Bot, Joost, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Menno Krietemeijer, G., Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Cornelissen, Sandra, Brans, Rutger, Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Hofmeijer, Jeannette, Martens, Jasper M., Bart van der Worp, H., Lo, Rob H., Hofmeijer, Jeannette, Zwenneke Flach, H., Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E.D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., and Boodt, Nikki
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- 2024
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8. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study
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Zonneveld, Thomas P, Vermeer, Sarah E, van Zwet, Erik W, Groot, Adrien E D, Algra, Ale, Aerden, Leo A M, Alblas, Kees C L, de Beer, Frank, Brouwers, Paul J A M, de Gans, Koen, van Gemert, H Maarten A, van Ginneken, Bart C A M, Grooters, Gerke S, Halkes, Patricia H A, van der Heijden-Montfroy, Tonny A M H G, Jellema, Korné, de Jong, Sonja W, Lövenich-Ciccarello, Harry, van der Meulen, Willem D M, Peters, Edwin W, van der Ree, Taco C, Remmers, Michel J M, Richard, Edo, Rovers, Jörgen M P, Saxena, Ritu, van Schaik, Sander M, Schonewille, Wouter J, Schreuder, Tobien A H C M L, de Schryver, Els L L M, Schuiling, Wouter J, Spaander, Fianne H, van Tuijl, Julia H, Visser, Marieke C, Zinkstok, Sanne M, Zock, Elles, Dippel, Diederik W J, Kappelle, L Jaap, van Oostenbrugge, Robert J, Roos, Yvo B W E M, Vermeij, Frederique H, Wermer, Marieke J H, van der Worp, H Bart, Nederkoorn, Paul J, and Kruyt, Nyika D
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- 2024
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9. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials
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Zi, Wenjie, Nogueira, Raul, Yang, Qingwu, Liu, Jianmin, Yang, Pengfei, Zhang, Yongwei, Yan, Bernard, Mitchell, Peter, Miao, Zhong Rong, Majoie, Charles B., Roos, Yvo B., Suzuki, Kentaro, Kimura, Kazumi, Matsumaru, Yuji, Fischer, Urs, Gralla, Jan, Cavalcante, Fabiano W., Kappelhof, Manon, Treurniet, Kilian M., Kaesmacher, Johannes, Zhang, Lei, Bush, Steven, Nieboer, Daan, Lingsma, Hester F., Rothwell, Peter, Saver, Jeffrey, Fiehler, Jens, Li, Fengli, Huang, Jiacheng, Song, Jiaxing, Hong, Bo, Chen, Wenhuo, Peng, Ya, Han, Hongxing, Zhang, Liyong, Li, Zifu, Xing, Pengfei, Shen, Hongjian, Zhang, Ping, Zhang, Xiaoxi, Davis, Stephen, Nguyen, Huy-Thang, Donnan, Geoffrey, Huo, Xiaochuan, Nan, Guangxian, Bivard, Andrew, Ma, Henry, Vu, Dang Lu, Campbell, Bruce, Rinkel, Leon A., Emmer, Bart J., Coutinho, Jonathan M., LeCouffe, Natalie E., Dippel, Diederik W., van der Lugt, Aad, van Zwam, Wim H., van Oostenbrugge, Robert J., Uyttenboogaart, Maarten, Costalat, Vincent, Lycklama, Geert, Hofmeijer, Jeannette, van Norden, Anouk, Otsuka, Toshiaki, Takeuchi, Masataka, Morimoto, Masafumi, Kanazawa, Ryuzaburo, Takayama, Yohei, Kamiya, Yuki, Shigeta, Keigo, Okubo, Seiji, Hayakawa, Mikito, Strbian, Daniel, Eker, Omer, Cognard, Christophe, Meinel, Thomas, Dobrocky, Tomas, Jung, Simon, Piechowiak, Eike, Marnat, Gaultier, Sibon, Igor, Bourcier, Romain, de Gaalon, Solene, Papagiannaki, Chrysanthi, Lefebvre, Margaux, Majoie, Charles B, Cavalcante, Fabiano, Treurniet, Kilian M, Miao, Zhongrong, Rinkel, Leon A, Wang, Shouchun, Coutinho, Jonathan M, Emmer, Bart J, LeCouffe, Natalie E, Lingsma, Hester F, Nogueira, Raul G, and Roos, Yvo B
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- 2023
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10. Association of primary and secondary hemostasis biomarkers with acute ischemic stroke outcome in patients undergoing thrombectomy, with or without thrombolytics: post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands-NO IV
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Barakzie, Aarazo, Jansen, Gerard A.J., Cavalcante, Fabiano, Nagy, Magdolna, Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Majoie, Charles B.L.M., ten Cate, Hugo, and de Maat, Moniek P.M.
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- 2024
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11. Budget impact of endovascular treatment for acute ischaemic stroke patients in the Netherlands for 2015–2021
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van den Berg, Lucie A., Berkhemer, Olvert A., Fransen, Puck S. S., Beumer, Debbie, Majoie, Charles B. L., Dippel, Diederik W. J., van der Lugt, Aad, van Oostenbrugge, Robert J., van Zwam, Wim H., Roos, Yvo B., and Dijkgraaf, Marcel G. W.
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- 2023
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12. Association between computed tomography perfusion and the effect of intravenous alteplase prior to endovascular treatment in acute ischemic stroke
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Hoving, Jan W., van Voorst, Henk, Peerlings, Daan, Daems, Jasper D., Koopman, Miou S., Wouters, Anke, Kappelhof, Manon, LeCouffe, Natalie E., Treurniet, Kilian M., Bruggeman, Agnetha A. E., Rinkel, Leon A., van den Wijngaard, Ido R., Coutinho, Jonathan M., van der Lugt, Aad, Marquering, Henk A., Roos, Yvo B. W. E. M., Majoie, Charles B. L. M., and Emmer, Bart J.
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- 2023
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13. Automated Final Lesion Segmentation in Posterior Circulation Acute Ischemic Stroke Using Deep Learning.
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Zoetmulder, Riaan, Konduri, Praneeta, Obdeijn, Iris, Gavves, Efstratios, Išgum, Ivana, Majoie, Charles, Dippel, Diederik, Roos, Yvo, Goyal, Mayank, Mitchell, Peter, Campbell, Bruce, Lopes, Demetrius, Reimann, Gernot, Jovin, Tudor, Saver, Jeffrey, Muir, Keith, White, Phil, Bracard, Serge, Chen, Bailiang, Brown, Scott, Schonewille, Wouter, van der Hoeven, Erik, Puetz, Volker, and Marquering, Henk
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CT ,deep learning ,posterior stroke ,segmentation ,transfer learning - Abstract
Final lesion volume (FLV) is a surrogate outcome measure in anterior circulation stroke (ACS). In posterior circulation stroke (PCS), this relation is plausibly understudied due to a lack of methods that automatically quantify FLV. The applicability of deep learning approaches to PCS is limited due to its lower incidence compared to ACS. We evaluated strategies to develop a convolutional neural network (CNN) for PCS lesion segmentation by using image data from both ACS and PCS patients. We included follow-up non-contrast computed tomography scans of 1018 patients with ACS and 107 patients with PCS. To assess whether an ACS lesion segmentation generalizes to PCS, a CNN was trained on ACS data (ACS-CNN). Second, to evaluate the performance of only including PCS patients, a CNN was trained on PCS data. Third, to evaluate the performance when combining the datasets, a CNN was trained on both datasets. Finally, to evaluate the performance of transfer learning, the ACS-CNN was fine-tuned using PCS patients. The transfer learning strategy outperformed the other strategies in volume agreement with an intra-class correlation of 0.88 (95% CI: 0.83-0.92) vs. 0.55 to 0.83 and a lesion detection rate of 87% vs. 41-77 for the other strategies. Hence, transfer learning improved the FLV quantification and detection rate of PCS lesions compared to the other strategies.
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- 2021
14. Prediction of Outcome and Endovascular Treatment Benefit
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Venema, Esmee, Roozenbeek, Bob, Mulder, Maxim JHL, Brown, Scott, Majoie, Charles BLM, Steyerberg, Ewout W, Demchuk, Andrew M, Muir, Keith W, Dávalos, Antoni, Mitchell, Peter J, Bracard, Serge, Berkhemer, Olvert A, Lycklama à Nijeholt, Geert J, van Oostenbrugge, Robert J, Roos, Yvo BWEM, van Zwam, Wim H, van der Lugt, Aad, Hill, Michael D, White, Philip, Campbell, Bruce CV, Guillemin, Francis, Saver, Jeffrey L, Jovin, Tudor G, Goyal, Mayank, Dippel, Diederik WJ, Lingsma, Hester F, der Lugt, Aad van, Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo GH, Goldhoorn, Robert-Jan B, Compagne, Kars CJ, Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J, Hinsenveld, Wouter H, van Es, Adriaan CGM, Emmer, Bart J, Coutinho, Jonathan M, Schonewille, Wouter J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M, de Bruijn, Sebastiaan F, van Dijk, Lukas C, van der Worp, H Bart, Lo, Rob H, van Dijk, Ewoud J, Boogaarts, Hieronymus D, Vries, J de, de Kort, Paul LM, van Tuijl, Julia, Peluso, Jo P, Fransen, Puck, van den Berg, Jan SP, van Hasselt, Boudewijn AAM, Aerden, Leo AM, Dallinga, René J, Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud PH, Schreuder, Tobien HCML, Heijboer, Roel JJ, Keizer, Koos, Yo, Lonneke SF, den Hertog, Heleen M, Bulut, Tomas, Brouwers, Paul JAM, Sprengers, Marieke ES, Jenniskens, Sjoerd FM, van den Berg, René, Yoo, Albert J, Beenen, Ludo FM, Postma, Alida A, Roosendaal, Stefan D, van der Kallen, Bas FW, van den Wijngaard, Ido R, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P, Krietemeijer, G Menno, Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, and Appelman, Auke PA
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Clinical Trials and Supportive Activities ,Clinical Research ,Stroke ,Brain Disorders ,Neurosciences ,Aged ,Aged ,80 and over ,Brain Ischemia ,Endovascular Procedures ,Humans ,Ischemic Stroke ,Male ,Middle Aged ,Registries ,Thrombectomy ,Treatment Outcome ,ischemic stroke ,registry ,reperfusion ,thrombectomy ,uncertainty ,HERMES collaborators and MR CLEAN Registry Investigators* ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Background and purposeBenefit of early endovascular treatment (EVT) for ischemic stroke varies considerably among patients. The MR PREDICTS decision tool, derived from MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), predicts outcome and treatment benefit based on baseline characteristics. Our aim was to externally validate and update MR PREDICTS with data from international trials and daily clinical practice.MethodsWe used individual patient data from 6 randomized controlled trials within the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration to validate the original model. Then, we updated the model and performed a second validation with data from the observational MR CLEAN Registry. Primary outcome was functional independence (defined as modified Rankin Scale score 0–2) 3 months after stroke. Treatment benefit was defined as the difference between the probability of functional independence with and without EVT. Discriminative performance was evaluated using a concordance (C) statistic.ResultsWe included 1242 patients from HERMES (633 assigned to EVT, 609 assigned to control) and 3156 patients from the MR CLEAN Registry (all of whom underwent EVT within 6.5 hours). The C-statistic for functional independence was 0.74 (95% CI, 0.72–0.77) in HERMES and, after model updating, 0.80 (0.78–0.82) in the Registry. Median predicted treatment benefit of routinely treated patients (Registry) was 10.3% (interquartile range, 5.8%–14.4%). Patients with low (
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- 2021
15. Mathematical modelling of haemorrhagic transformation in the human brain
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Chen, Xi, Wang, Jiayu, van Kranendonk, Katinka R., Józsa, Tamas.I., El-Bouri, Wahbi K., Kappelhof, Manon, van der Sluijs, Matthijs, Dippel, Diederik, Roos, Yvo B.W.M., Marquering, Henk A, Majoie, Charles B.L.M., and Payne, Stephen J.
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- 2023
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16. Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial
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Olthuis, Susanne G H, Pirson, F Anne V, Pinckaers, Florentina M E, Hinsenveld, Wouter H, Nieboer, Daan, Ceulemans, Angelique, Knapen, Robrecht R M M, Robbe, M M Quirien, Berkhemer, Olvert A, van Walderveen, Marianne A A, Lycklama à Nijeholt, Geert J, Uyttenboogaart, Maarten, Schonewille, Wouter J, van der Sluijs, P Matthijs, Wolff, Lennard, van Voorst, Henk, Postma, Alida A, Roosendaal, Stefan D, van der Hoorn, Anouk, Emmer, Bart J, Krietemeijer, Menno G M, van Doormaal, Pieter-Jan, Roozenbeek, Bob, Goldhoorn, Robert-Jan B, Staals, Julie, de Ridder, Inger R, van der Leij, Christiaan, Coutinho, Jonathan M, van der Worp, H Bart, Lo, Rob T H, Bokkers, Reinoud P H, van Dijk, Ewoud I, Boogaarts, Hieronymus D, Wermer, Marieke J H, van Es, Adriaan C G M, van Tuijl, Julia H, Kortman, Hans G J, Gons, Rob A R, Yo, Lonneke S F, Vos, Jan-Albert, de Laat, Karlijn F, van Dijk, Lukas C, van den Wijngaard, Ido R, Hofmeijer, Jeannette, Martens, Jasper M, Brouwers, Paul J A M, Bulut, Tomas, Remmers, Michel J M, de Jong, Thijs E A M, den Hertog, Heleen M, van Hasselt, Boudewijn A A M, Rozeman, Anouk D, Elgersma, Otto E H, van der Veen, Bas, Sudiono, Davy R, Lingsma, Hester F, Roos, Yvo B W E M, Majoie, Charles B L M, van der Lugt, Aad, Dippel, Diederik W J, van Zwam, Wim H, and van Oostenbrugge, Robert J
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- 2023
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17. Early Intubation in Endovascular Therapy for Basilar Artery Occlusion: A Post Hoc Analysis of the BASICS Trial
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Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., van Zwam, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., Puetz, Volker, Schonewille, W.J., Vos, J.A., van der Hoeven, E.J.R.J., van Leersum, M., van den Heuvel, D.A.F., van Strijen, M.J.L., Teunissen, L.L., van der Lugt, A., van Es, A. C.G.M., van Doormaal, P.J., Kappelle, L.J., Lo, T.H., van der Worp, H.B., Boiten, J., Lycklama à Nijeholt, G.J., Nederkoorn, P.J., Majoie, C.B.L.M., Coutinho, J., Staals, J., Hofmeijer, J., Martens, J., Bernsen, M.L., Wermer, M.J.H., van Walderveen, M.A.A., Remmers, M.J.M., de Laat, K.F., de Kort, P.L.M., Mont’Alverne, F.J., Carvalho, J.J.F., de Araújo Rocha, F., de Almeida Bandeira, D., Freitas de Lucena, A., Coelho Silva, H., Martins, S.O, Dias, F.A., Abud, D.G., Cerantola, R., Camilo, M., Alves, F. A., Martins, R.K., Nakiri, G., Castro-Afonso, L.H., Pallesen, L.P., Barlinn, J., Siepmann, T., Nolte, C.H., Erdur, H., Scheitz, J.F., Szabo, K., Schneider, H., Berlis, A., Maurer, C., Ertl, M., Zickler, P., Schneider, C., Rueckert, C., Piotin, M., Ben Maacha, M., Blanc, R., Desilles, J.P., Redjem, H., Escalard, S., Smajda, S., Ciccio, G., Maier, B., Devoye, F., Herbert, S., Zini, A., Vallone, S., Bigliardi, G., Dell’Acqua, M.L., Rosafio, F., Verganti, L., Zelent, G., Maffei, S., Meyer, I., and Herzig, R.
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- 2023
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18. In silico thrombectomy trials for acute ischemic stroke
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Miller, Claire, Konduri, Praneeta, Bridio, Sara, Luraghi, Giulia, Arrarte Terreros, Nerea, Boodt, Nikki, Samuels, Noor, Rodriguez Matas, Jose F., Migliavacca, Francesco, Lingsma, Hester, van der Lugt, Aad, Roos, Yvo, Dippel, Diederik, Marquering, Henk, Majoie, Charles, and Hoekstra, Alfons
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- 2023
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19. Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions
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Bruggeman, Agnetha A. E., Aberson, Nyk, Kappelhof, Manon, Dutra, Bruna G., Hoving, Jan W., Brouwer, Josje, Tolhuisen, Manon L., Terreros, Nerea Arrarte, Konduri, Praneeta R., Boodt, Nikki, Roos, Yvo B. W. E. M., van Zwam, Wim H., Bokkers, Reinoud, Martens, Jasper, Marquering, Henk A., Emmer, Bart J., and Majoie, Charles B. L. M.
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- 2022
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20. Prediction of final infarct volume from native CT perfusion and treatment parameters using deep learning
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Robben, David, Boers, Anna M. M., Marquering, Henk A., Langezaal, Lucianne L. C. M., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Dippel, Diederik W. J., Majoie, Charles B. L. M., van der Lugt, Aad, Lemmens, Robin, and Suetens, Paul
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Physics - Medical Physics - Abstract
CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We pursue a data-driven and deconvolution-free approach, where a deep neural network learns to predict the final infarct volume directly from the native CTP images and metadata such as the time parameters and treatment. This would allow clinicians to simulate various treatments and gain insight into predicted tissue status over time. We demonstrate on a multicenter dataset that our approach is able to predict the final infarct and effectively uses the metadata. An ablation study shows that using the native CTP measurements instead of the deconvolved measurements improves the prediction., Comment: Accepted for publication in Medical Image Analysis
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- 2018
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21. Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial
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Yang, Pengfei, Song, Lili, Zhang, Yongwei, Zhang, Xiaoxi, Chen, Xiaoying, Li, Yunke, Sun, Lingli, Wan, Yingfeng, Billot, Laurent, Li, Qiang, Ren, Xinwen, Shen, Hongjian, Zhang, Lei, Li, Zifu, Xing, Pengfei, Zhang, Yongxin, Zhang, Ping, Hua, Weilong, Shen, Fang, Zhou, Yihan, Tian, Bing, Chen, Wenhuo, Han, Hongxing, Zhang, Liyong, Xu, Chenghua, Li, Tong, Peng, Ya, Yue, Xincan, Chen, Shengli, Wen, Changming, Wan, Shu, Yin, Congguo, Wei, Ming, Shu, Hansheng, Nan, Guangxian, Liu, Sheng, Liu, Wenhua, Cai, Yiling, Sui, Yi, Chen, Maohua, Zhou, Yu, Zuo, Qiao, Dai, Dongwei, Zhao, Rui, Huang, Qinghai, Xu, Yi, Deng, Benqiang, Wu, Tao, Lu, Jianping, Wang, Xia, Parsons, Mark W, Butcher, Ken, Campbell, Bruce, Robinson, Thompson G, Goyal, Mayank, Dippel, Diederik, Roos, Yvo, Majoie, Charles, Wang, Longde, Wang, Yongjun, Liu, Jianmin, and Anderson, Craig S
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- 2022
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22. Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial
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van Ahee, Ayla, Visseren, Frank, Halkes, Patricia, van Eijk, Ruben, Simons, Michelle, Pellikaan, Wilma, Van Wijngaarden, Wilma, Ponjee, Eva, Geijtenbeek, Petra, Arts, Ton, Zock, Elles, Oudshoorn, Wilma, Steenwinkel, Frans, Samim, Hamdia, van Zandwijk, Mark, Vrielink, Lisette, Mulder, Peter Jan, Gerritsen, Aico, Ijzermans, Jim, Kooijman, Marjan, Francissen, Oscar, van Nuland, Rick, van Zwam, Wim, Jacobi, Linda, van den Berg, Rene, Beenen, Ludo, van Es, Adriaan, van Doormaal, Pieter-Jan, Lycklama a Nijeholt, Geert, van den Wijngaard, Ido, Yoo, Albert, Yo, Lonneke, Martens, Jasper, Hammer, Bas, Roosendaal, Stefan, Meijer, Anton, Krietemeijer, Menno, Bokkers, Reinoud, van der Hoorn, Anouk, Gerrits, Dick, Coutinho, Jonathan, Jansen, Ben, Manschot, Sanne, Koudstaal, Peter, Keizer, Koos, Chalos, Vicky, Versteeg, Adriaan, Wolff, Lennard, van Voorst, Henk, van der Sluijs, Matthijs, Hoving, Arnolt-Jan, Treurniet, Kilian, LeCouffe, Natalie, van de Graaf, Rob, Goldhoorn, Robert-Jan, Hinseveld, Wouter, Pirson, Anne, Sondag, Lotte, Kappelhof, Manon, Tolhuisen, Manon, Brouwer, Josje, van der Steen, Wouter, Rinkel, Leon, Bruggeman, Agnetha, Sprengers, Rita, Sterrenberg, Martin, Verheesen, Sabrina, Heiligers, Leontien, Martens, Yvonne, El Ghannouti, Naziha, Slotboom, Miranda, van den Berg, Sophie A, Uniken Venema, Simone M, Reinink, Hendrik, Hofmeijer, Jeannette, Schonewille, Wouter J, Miedema, Irene, Fransen, Puck S S, O Pruissen, D Martijn, Raaijmakers, Theodora W M, van Dijk, Gert W, de Leeuw, Frank-Erik, van Vliet, Jorine A, Kwa, Vincent I H, Kerkhoff, Henk, van 't Net, Alex, Boomars, Rene, Siegers, Arjen, Lok, Tycho, Caminada, Klaartje, Esteve Cuevas, Laura M, Visser, Marieke C, Zwetsloot, Casper P, Boomsma, Jooske M F, Schipper, Mirjam H, van Eijkelenburg, Roeland P J, Berkhemer, Olvert A, Nieboer, Daan, Lingsma, Hester F, Emmer, Bart J, van Oostenbrugge, Robert J, van der Lugt, Aad, Roos, Yvo B W E M, Majoie, Charles B L M, Dippel, Diederik W J, Nederkoorn, Paul J, and van der Worp, H Bart
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- 2022
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23. Detection of large vessel occlusion stroke with electroencephalography in the emergency room: first results of the ELECTRA-STROKE study
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van Meenen, Laura C. C., van Stigt, Maritta N., Marquering, Henk A., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., Koelman, Johannes H. T. M., Potters, Wouter V., and Coutinho, Jonathan M.
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- 2022
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24. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice
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van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., van Zwam, Wim H., van der Lugt, Aad, van der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert- Jan B., Compagne, Kars C.J., Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Vos, Jan Albert, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Lycklama à Nijeholt, Geert J., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Vos, Jan Albert, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Krietemeijer, G. Menno, Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Dippel, Diederik W.J., van Oostenbrugge, Robert J., Lycklama à Nijeholt, Geert J., Vos, Jan Albert, Schonewille, Wouter J., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., LeCouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.
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- 2023
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25. Endovascular Thrombectomy Alone for Large Vessel Occlusion: A Cost-Effectiveness Evaluation Based on Meta-Analyses.
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Chi Phuong Nguyen, Lahr, Maarten M. H., van der Zee, Durk-Jouke, Rinkel, Leon A., van Voorst, Henk, Pinckaers, Florentina M. E., Cavalcante, Fabiano, LeCouffe, Natalie E., Kappelhof, Manon, Treurniet, Kilian M., Coutinho, Jonathan M., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., Buskens, Erik, and Uyttenboogaart, Maarten
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- 2024
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26. Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial
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van der Steen, Wouter, van de Graaf, Rob A, Chalos, Vicky, Lingsma, Hester F, van Doormaal, Pieter Jan, Coutinho, Jonathan M, Emmer, Bart J, de Ridder, Inger, van Zwam, Wim, van der Worp, H Bart, van der Schaaf, Irene, Gons, Rob A R, Yo, Lonneke S F, Boiten, Jelis, van den Wijngaard, Ido, Hofmeijer, Jeannette, Martens, Jasper, Schonewille, Wouter, Vos, Jan Albert, Tuladhar, Anil Man, de Laat, Karlijn F, van Hasselt, Boudewijn, Remmers, Michel, Vos, Douwe, Rozeman, Anouk, Elgersma, Otto, Uyttenboogaart, Maarten, Bokkers, Reinoud P H, van Tuijl, Julia, Boukrab, Issam, van den Berg, René, Beenen, Ludo F M, Roosendaal, Stefan D, Postma, Alida Annechien, Krietemeijer, Menno, Lycklama, Geert, Meijer, Frederick J A, Hammer, Sebastiaan, van der Hoorn, Anouk, Yoo, Albert J, Gerrits, Dick, Truijman, Martine T B, Zinkstok, Sanne, Koudstaal, Peter J, Manschot, Sanne, Kerkhoff, Henk, Nieboer, Daan, Berkhemer, Olvert, Wolff, Lennard, van der Sluijs, P Matthijs, van Voorst, Henk, Tolhuisen, Manon, Roos, Yvo B W E M, Majoie, Charles B L M, Staals, Julie, van Oostenbrugge, Robert J, Jenniskens, Sjoerd F M, van Dijk, Lukas C, den Hertog, Heleen M, van Es, Adriaan C G M, van der Lugt, Aad, Dippel, Diederik W J, and Roozenbeek, Bob
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- 2022
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27. Value of infarct location in the prediction of functional outcome in patients with an anterior large vessel occlusion: results from the HERMES study
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Tolhuisen, Manon L., Ernst, Marielle, Boers, Anne M. M., Brown, Scott, Beenen, Ludo F. M., Guillemin, Francis, Roos, Yvo B. W. E. M., Saver, Jeffrey L., van Oostenbrugge, Robert, Demchuck, Andrew M., van Zwam, Wim, Jovin, Tudor G., Berkhemer, Olvert A., Muir, Keith W., Bracard, Serge, Campbell, Bruce C. V., van der Lugt, Aad, White, Phill, Hill, Michael D., Dippel, Diederik W. J., Mitchell, Peter J., Goyal, Mayank, Caan, Matthan W. A., Marquering, Henk A., and Majoie, Charles B. L. M.
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- 2022
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28. Estimation of treatment effects in observational stroke care data: comparison of statistical approaches
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Amini, Marzyeh, van Leeuwen, Nikki, Eijkenaar, Frank, van de Graaf, Rob, Samuels, Noor, van Oostenbrugge, Robert, van den Wijngaard, Ido R., van Doormaal, Pieter Jan, Roos, Yvo B. W. E. M., Majoie, Charles, Roozenbeek, Bob, Dippel, Diederik, Burke, James, and Lingsma, Hester F.
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- 2022
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29. Cross‐Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy
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Kaesmacher, Johannes, primary, Treurniet, Kilian M., additional, Kappelhof, Manon, additional, Dobrocky, Tomas, additional, Ospel, Johanna, additional, Mujanovic, Adnan, additional, Fiehler, Jens, additional, Yan, Bernard, additional, Goyal, Mayank, additional, Yoo, Albert J., additional, Campbell, Bruce, additional, Zaidat, Osama O., additional, Saver, Jeffrey L., additional, Sanossian, Nerses, additional, Raychev, Radoslav, additional, Roos, Yvo B. W. E. M., additional, Fischer, Urs, additional, Majoie, Charles B. L. M., additional, Gralla, Jan, additional, and Liebeskind, David S., additional
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- 2024
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30. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, 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Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, 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Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, Majoie, Charles B L M, Menon, Bijoy K, van Zwam, Wim H, van Oostenbrugge, Robert J, Demchuk, Andrew M, Guillemin, Francis, Dávalos, Antoni, Butcher, Kenneth S, Cherifi, Aboubaker, Marquering, Henk A, Macho Fernández, Juan M, Oppenheim, Catherine, Roos, Yvo B W E M, Shankar, Jai, Lingsma, Hester, Hernández-Pérez, María, Bharatha, Aditya, Levy, Elad I, Soudant, Marc, Aja, Lucia, Krings, Timo, Tisserand, Marie, San Román, Luis, Tomasello, Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
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- 2019
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31. Quantitative 3D analysis of tissue damage in a rat model of microembolization
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Majoie, Charles, Marquering, Henk, van Bavel, Ed, Hoekstra, Alfons, Dippel, Diederik, Lingsma, Hester, van der Lugt, Aad, Samuels, Noor, Boodt, Nikki, Roos, Yvo, De Meyer, Simon F, Staessens, Senna, Vandelanotte, Sarah, Konduri, Praneeta, Terreros, Nerea Arrarte, Chopard, Bastien, Raynaud, Franck, Petkantchin, Remy, Panteleev, Mikhail, Shibeko, Alexey, Boudjeltia, Karim Zouaoui, Blanc-Guillemaud, Vanessa, Migliavacca, Francesco, Dubini, Gabriele, Luraghi, Giulia, Matas, Jose Felix Rodriguez, Bridio, Sara, Mc Garry, Patrick, Gilvarry, Michael, McCarthy, Ray, Moerman, Kevin, Fereidoonnezhad, Behrooz, Dwivedi, Anushree, Duffy, Sharon, Payne, Stephen, Jozsa, Tamas, Georgakopoulou, Sissy, Padmos, Raymond, Azizi, Victor, Miller, Claire, van der Kolk, Max, Georgakopoulou, Theodosia, van der Wijk, Anne-Eva, Bakker, Erik N.T.P., and vanBavel, Ed
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- 2021
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32. Intracranial carotid artery calcification subtype and collaterals in patients undergoing endovascular thrombectomy
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Luijten, Sven P.R., van der Donk, Sophie C., Compagne, Kars C.J., Yo, Lonneke S.F., Sprengers, Marieke E.S., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., van Zwam, Wim H., van Oostenbrugge, Robert, Dippel, Diederik W.J., van der Lugt, Aad, Roozenbeek, Bob, and Bos, Daniel
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- 2021
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33. Antifibrinolytic Therapy for Aneurysmal Subarachnoid Hemorrhage: An Update of a Cochrane Systematic Review
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Germans, Menno R., Dronkers, Wouter J., Baharoglu, M. Irem, Post, René, Verbaan, Dagmar, Rinkel, Gabriël J.E., and Roos, Yvo B.W.E.M.
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- 2023
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34. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
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Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J
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- 2021
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35. Ultra-Early and Short-Term Tranexamic Acid Treatment in Patients With Good- and Poor-Grade Aneurysmal Subarachnoid Hemorrhage
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Neurologen, Brain, Circulatory Health, Projectafdeling CVZ, Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korne, Koot, Radboud W., Kruyt, Nyika D., Wolfs, Jasper F.C., De Beer, Frits C., Kieft, Hans H., Nanda, Dharmin, Van Der Pol, Bram, Roks, Gerwin, De Beer, Frank, Reichman, Loes J.A., Brouwers, Paul J.A.M., Kwa, Vincent I.H., Van Der Ree, Taco C., Bienfait, Henri P., Boogaarts, Hieronymus D., Klijn, Catharina J., Visser, Victoria, van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., Vandertop, W. Peter, Verbaan, Dagmar, ULTRA trial study group, Neurologen, Brain, Circulatory Health, Projectafdeling CVZ, Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korne, Koot, Radboud W., Kruyt, Nyika D., Wolfs, Jasper F.C., De Beer, Frits C., Kieft, Hans H., Nanda, Dharmin, Van Der Pol, Bram, Roks, Gerwin, De Beer, Frank, Reichman, Loes J.A., Brouwers, Paul J.A.M., Kwa, Vincent I.H., Van Der Ree, Taco C., Bienfait, Henri P., Boogaarts, Hieronymus D., Klijn, Catharina J., Visser, Victoria, van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., Vandertop, W. Peter, Verbaan, Dagmar, and ULTRA trial study group
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- 2024
36. Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage
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Neurologen, Brain, Circulatory Health, UMC Utrecht, Germans, Menno R., Tjerkstra, Maud A., Post, René, Brenner, Amy, Vergouwen, Mervyn D.I., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., van den Berg, René, Coert, Bert A., Vandertop, W. Peter, Verbaan, Dagmar, Neurologen, Brain, Circulatory Health, UMC Utrecht, Germans, Menno R., Tjerkstra, Maud A., Post, René, Brenner, Amy, Vergouwen, Mervyn D.I., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., van den Berg, René, Coert, Bert A., Vandertop, W. Peter, and Verbaan, Dagmar
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- 2024
37. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study
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Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., Kruyt, Nyika D., Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., and Kruyt, Nyika D.
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- 2024
38. Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis
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Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, IRIS Collaborators, Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, and IRIS Collaborators
- Abstract
IMPORTANCE: The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines with longer time from symptom onset, but it is not known whether a similar time dependency exists for IVT followed by thrombectomy. OBJECTIVE: To determine whether the benefit associated with IVT plus thrombectomy vs thrombectomy alone decreases with treatment time from symptom onset. DESIGN, SETTING, AND PARTICIPANTS: Individual participant data meta-analysis from 6 randomized clinical trials comparing IVT plus thrombectomy vs thrombectomy alone. Enrollment was between January 2017 and July 2021 at 190 sites in 15 countries. All participants were eligible for IVT and thrombectomy and presented directly at thrombectomy-capable stroke centers (n?=?2334). For this meta-analysis, only patients with an anterior circulation large-vessel occlusion were included (n?=?2313). EXPOSURE: Interval from stroke symptom onset to expected administration of IVT and treatment with IVT plus thrombectomy vs thrombectomy alone. MAIN OUTCOMES AND MEASURES: The primary outcome analysis tested whether the association between the allocated treatment (IVT plus thrombectomy vs thrombectomy alone) and disability at 90 days (7-level modified Rankin Scale [mRS] score range, 0 [no symptoms] to 6 [death]; minimal clinically important difference for the rates of mRS scores of 0-2: 1.3%) varied with times from symptom onset to expected administration of IVT. RESULTS: In 2313 participants (1160 in IVT plus thrombectomy group vs 1153 in thrombectomy alone group; median age, 71 [IQR, 62 to 78] years; 44.3% were female), the median time from symptom onset to expected administration of IVT was 2 hours 28 minutes (IQR, 1 hour 46 minutes to 3 hours 17 minutes). There was a statistically significant interaction between the time from symptom onset to expected administration of IVT and the association of allocated treatment with functional outcomes (ratio of adjusted common odds ratio [OR] per 1-hour delay, 0.84 [95%
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- 2024
39. Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke
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Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., Majoie, Charles B.L.M., Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., and Majoie, Charles B.L.M.
- Abstract
The early management of transferred patients with a large vessel occlusion (LVO) stroke could be improved by identifying patients who are likely to recanalize early. We aim to predict early recanalization based on patient clinical and thrombus imaging characteristics. We included 81 transferred anterior-circulation LVO patients with an early recanalization, defined as the resolution of the LVO or the migration to a distal location not reachable with endovascular treatment upon repeated radiological imaging. We compared their clinical and imaging characteristics with all (322) transferred patients with a persistent LVO in the MR CLEAN Registry. We measured distance from carotid terminus to thrombus (DT), thrombus length, density, and perviousness on baseline CT images. We built logistic regression models to predict early recanalization. We validated the predictive ability by computing the median area-under-the-curve (AUC) of the receiver operating characteristics curve for 100 5-fold cross-validations. The administration of intravenous thrombolysis (IVT), longer transfer times, more distal occlusions, and shorter, pervious, less dense thrombi were characteristic of early recanalization. After backward elimination, IVT administration, DT and thrombus density remained in the multivariable model, with an AUC of 0.77 (IQR 0.72–0.83). Baseline thrombus imaging characteristics are valuable in predicting early recanalization and can potentially be used to optimize repeated imaging workflow.
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- 2024
40. Advancements in diagnostic and interventional radiology for stroke treatment:the path from trial to bedside through the pre-MR CLEAN, MR CLEAN, and MR CLEAN II eras
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Samuels, Noor, van de Graaf, Rob A., Roos, Yvo B.W.M., Dippel, Diederik, van der Lugt, Aad, Samuels, Noor, van de Graaf, Rob A., Roos, Yvo B.W.M., Dippel, Diederik, and van der Lugt, Aad
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The stroke field is inevitably connected with imaging in which radiologists fulfill a central role. Our landmark MR CLEAN trial led to the implementation of baseline computed tomography angiography or magnetic resonance angiography in the acute stroke workup and subsequent endovascular treatment (EVT) for ischemic stroke patients with a large vessel occlusion in the anterior circulation, resulting in numerous patients worldwide currently being treated often successfully. A reversal of the pathophysiologic process behind an acute cerebrovascular event was made possible. Subsequently, in the MR CLEAN II trials, the clinical impact of both diagnostic and interventional radiologists remained a cornerstone of our research, which means value-based radiology. Within these MR CLEAN II trials, we proved that aspirin and heparin during EVT should be avoided due to increased symptomatic intracranial hemorrhage risk (MR CLEAN-MED). We concluded there is additional benefit of EVT in the 6-to-24-h window after stroke in the presence of good collaterals on baseline CTA (MR CLEAN-LATE). The impactful success of our stroke trials that changed many guidelines was mainly attributable to (1) the societal burden of the disease, with two thirds of patients dying or being independent at 3 months; (2) the fact that stroke is a common disease, (3) the relatively simple and pragmatic approach of the trials resembling real-world setting; (4) the acceleration of implementation in clinical practice facilitated by a structured approach to guideline development and conditional funding; and foremost (5) the excellent collaboration on a professional level between-disciplines, i.e., diagnostic radiologists, interventionalists, and neurologists. Critical relevance statement The MR CLEAN and MR CLEAN II trials have had tremendous impact on clinical practice, directly by more patients being treated with an effective intervention and indirectly through adoption of evidence-based guidelines. It is in
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- 2024
41. Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage
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Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Brenner, Amy, Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Rinkel, Gabriël Je, Roos, Yvo Bwem; https://orcid.org/0000-0001-9205-5882, van den Berg, René, Coert, Bert A, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Brenner, Amy, Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Rinkel, Gabriël Je, Roos, Yvo Bwem; https://orcid.org/0000-0001-9205-5882, van den Berg, René, Coert, Bert A, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, and Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470
- Abstract
INTRODUCTION: The ULTRA-trial investigated effectiveness of ultra-early administration of tranexamic acid (TXA) in subarachnoid hemorrhage (SAH) and showed that TXA reduces the risk of rebleeding without concurrent improvement in clinical outcome. Previous trials in bleeding conditions, distinct from SAH, have shown that time to start of antifibrinolytic treatment influences outcome. This post-hoc analysis of the ULTRA-trial investigates whether the interval between hemorrhage and start of TXA impacts the effect of TXA on rebleeding and functional outcome following aneurysmal SAH. PATIENTS AND METHODS: A post-hoc comparative analysis was conducted between aneurysmal SAH patients of the ULTRA-trial, receiving TXA and usual care to those receiving usual care only. We assessed confounders, hazard ratio (HR) of rebleeding and odds ratio (OR) of good outcome (modified Rankin Scale 0-3) at 6 months, and investigated the impact of time between hemorrhage and start of TXA on the treatment effect, stratified into time categories (0-3, 3-6 and >6 h). RESULTS: Sixty-four of 394 patients (16.2%) in the TXA group experienced a rebleeding, compared to 83 of 413 patients (19.9%) with usual care only (HR 0.86, 95% confidence interval (CI): 0.62-1.19). Time to start of TXA modifies the effect of TXA on rebleeding rate (p < 0.001), with a clinically non-relevant reduction observed only when TXA was initiated after 6 h (absolute rate reduction 1.4%). Tranexamic acid treatment showed no effect on good outcome (OR 0.96, 95% CI: 0.72-1.27) with no evidence of effect modification on the time to start of TXA (p = 0.53). DISCUSSION AND CONCLUSIONS: This study suggests that the effect of TXA on rebleeding is modified by time to treatment, providing a protective, albeit clinically non-relevant, effect only when started after 6 h. No difference in functional outcome was seen. Routine TXA treatment in the aneurysmal SAH population, even within a specified time frame, is not recommended to impro
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- 2024
42. Ultra-Early and Short-Term Tranexamic Acid Treatment in Patients With Good- and Poor-Grade Aneurysmal Subarachnoid Hemorrhage
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Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Vergouwen, Mervyn D I; https://orcid.org/0000-0002-6823-1628, Jellema, Korne, Koot, Radboud W, Kruyt, Nyika D; https://orcid.org/0000-0002-2320-0932, Wolfs, Jasper F C, De Beer, Frits C; https://orcid.org/0000-0003-4725-7156, Kieft, Hans H; https://orcid.org/0000-0003-2083-710X, Nanda, Dharmin, Van Der Pol, Bram; https://orcid.org/0000-0001-5173-9989, Roks, Gerwin; https://orcid.org/0000-0002-1393-9848, De Beer, Frank, Reichman, Loes J A, Brouwers, Paul J A M, Kwa, Vincent I H; https://orcid.org/0000-0002-0942-6206, Van Der Ree, Taco C, Bienfait, Henri P; https://orcid.org/0000-0002-5698-0031, Boogaarts, Hieronymus D; https://orcid.org/0000-0001-5855-2447, Klijn, Catharina J; https://orcid.org/0000-0002-8495-4578, Visser, Victoria, van den Berg, René, Coert, Bert A, Horn, Janneke; https://orcid.org/0000-0002-3788-7675, Majoie, Charles B L M; https://orcid.org/0000-0002-7600-9568, Rinkel, Gabriël J E, Roos, Yvo B W E M; https://orcid.org/0000-0001-9205-5882, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Vergouwen, Mervyn D I; https://orcid.org/0000-0002-6823-1628, Jellema, Korne, Koot, Radboud W, Kruyt, Nyika D; https://orcid.org/0000-0002-2320-0932, Wolfs, Jasper F C, De Beer, Frits C; https://orcid.org/0000-0003-4725-7156, Kieft, Hans H; https://orcid.org/0000-0003-2083-710X, Nanda, Dharmin, Van Der Pol, Bram; https://orcid.org/0000-0001-5173-9989, Roks, Gerwin; https://orcid.org/0000-0002-1393-9848, De Beer, Frank, Reichman, Loes J A, Brouwers, Paul J A M, Kwa, Vincent I H; https://orcid.org/0000-0002-0942-6206, Van Der Ree, Taco C, Bienfait, Henri P; https://orcid.org/0000-0002-5698-0031, Boogaarts, Hieronymus D; https://orcid.org/0000-0001-5855-2447, Klijn, Catharina J; https://orcid.org/0000-0002-8495-4578, Visser, Victoria, van den Berg, René, Coert, Bert A, Horn, Janneke; https://orcid.org/0000-0002-3788-7675, Majoie, Charles B L M; https://orcid.org/0000-0002-7600-9568, Rinkel, Gabriël J E, Roos, Yvo B W E M; https://orcid.org/0000-0001-9205-5882, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, and Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470
- Abstract
The results of the ULTRA trial showed that ultra-early and short-term treatment with tranexamic acid (TXA) does not improve clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Possibly, the lack of a beneficial effect in all patients with aSAH is masked by antagonistic effects of TXA in certain subgroups. In this post hoc subgroup analysis, we investigated the effect of TXA on clinical outcome in patients with good-grade and poor-grade aSAH.
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- 2024
43. Value of Automatically Derived Full Thrombus Characteristics:An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients
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Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., Marquering, Henk A., Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., and Marquering, Henk A.
- Abstract
(1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-consuming and subject to inter-observer bias. Alternatively, a recently introduced fully automated deep learning-based algorithm can be used to consistently estimate full thrombus characteristics. Here, we exploratively assess the value of these novel biomarkers in terms of their association with stroke outcomes. (2) Methods: We studied two applications of automated full thrombus characterization as follows: one in a randomized trial, MR CLEAN-NO IV (n = 314), and another in a Dutch nationwide registry, MR CLEAN Registry (n = 1839). We used an automatic pipeline to determine the thrombus volume, perviousness, density, and heterogeneity. We assessed their relationship with the functional outcome defined as the modified Rankin Scale (mRS) at 90 days and two technical success measures as follows: successful final reperfusion, which is defined as an eTICI score of 2b-3, and successful first-pass reperfusion (FPS). (3) Results: Higher perviousness was significantly related to a better mRS in both MR CLEAN-NO IV and the MR CLEAN Registry. A lower thrombus volume and lower heterogeneity were only significantly related to better mRS scores in the MR CLEAN Registry. Only lower thrombus heterogeneity was significantly related to technical success; it was significantly related to a higher chance of FPS in the MR CLEAN-NO IV trial (OR = 0.55, 95% CI: 0.31–0.98) and successful reperfusion in the MR CLEAN Registry (OR = 0.88, 95% CI: 0.78–0.99). (4) Conclusions: Thrombus characteristics derived from automatic entire thrombus segmentations are significantly related to stroke outcomes.
- Published
- 2024
44. Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage: Post Hoc Analysis of the ULTRA Trial
- Author
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Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korné, Koot, Radboud W., Kruyt, Nyika D., Willems, Peter W.A., Wolfs, Jasper F.C., de Beer, Frits C., Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H.A., Reichman, Loes J.A., Brouwers, Paul J.A.M., Van den Berg-Vos, Renske M., Kwa, Vincent I.H., van der Ree, Taco C., Bronner, Irene, Bienfait, Henri P., Boogaarts, Hieronymus, Klijn, Catharina J.M., van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.M., Vandertop, W. Peter, and Verbaan, Dagmar
- Published
- 2022
- Full Text
- View/download PDF
45. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
- Author
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez-Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henniger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, 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Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Román, Luis San, Menon, Bijoy K, Blasco, Jordi, Hernández-Pérez, María, Dávalos, Antoni, Majoie, Charles B L M, Campbell, Bruce C V, Guillemin, Francis, Lingsma, Hester, Epstein, Jonathan, Marquering, Henk, Wong, John H, Lopes, Demetrius, Reimann, Gernot, Dippel, Diederik W J, Coutts, Shelagh, du Mesnil de Rochemont, Richard, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B W E M, Liebeskind, David S, Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
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46. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, 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Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil 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Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
- Published
- 2018
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47. Left Atrial Appendage Opacification on Cardiac Computed Tomography in Acute Ischemic Stroke: The Clinical Implications of Slow-Flow.
- Author
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Shan Sui Nio, Rinkel, Leon A., Cramer, Olivia N., Beyda Özata, Z., Beemsterboer, Chiel F. P., Guglielmi, Valeria, Bouma, Berto J., Matthijs Boekholdt, S., Lobé, Nick H. J., Beenen, Ludo F. M., Marquering, Henk A., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Randen, Adrienne, Nils Planken, R., and Coutinho, Jonathan M.
- Published
- 2024
- Full Text
- View/download PDF
48. Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage.
- Author
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Germans, Menno R, Tjerkstra, Maud A, Post, René, Brenner, Amy, Vergouwen, Mervyn DI, Rinkel, Gabriël JE, Roos, Yvo BWEM, van den Berg, René, Coert, Bert A, Vandertop, W Peter, and Verbaan, Dagmar
- Published
- 2024
- Full Text
- View/download PDF
49. HERMES-24 Score Derivation and Validation for Simple and Robust Outcome Prediction After Large Vessel Occlusion Treatment.
- Author
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Koji Tanaka, Brown, Scott, Goyal, Mayank, Menon, Bijoy K., Campbell, Bruce C. V., Mitchell, Peter J., Jovin, Tudor G., Saver, Jeffrey L., Muir, Keith W., White, Phil M., Bracard, Serge, Guillemin, Francis, Roos, Yvo B. W. E. M., van Zwam, Wim H., Najm, Mohamed, Dowlatshahi, Dar, Hill, Michael D., and Demchuk, Andrew M.
- Published
- 2024
- Full Text
- View/download PDF
50. Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry
- Author
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Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert-Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Hammer, Sebastiaan, Vos, Jan Albert, Boiten, Jelis, Coutinho, Jonathan M., Emmer, Bart J., van Es, Ad C.G.M., Roozenbeek, Bob, Roos, Yvo B.W.E.M., van Zwam, Wim H., van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., and van der Lugt, Aad
- Published
- 2022
- Full Text
- View/download PDF
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