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1. LiMeS-Lab: An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors

Author

Tanke, V. F. B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G. J., van Dommelen, J. A. W., van Eck, H. J. N., Geers, M. G. D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H. M., Vernimmen, J. W. M., Vos, E. G. P., and Morgan, T. W.

Published
2023
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2. Electronic reporting of rare endocrine conditions within a clinical network:results from the EuRRECa project

Author

Ali, S. R., Bryce, J., Priego-Zurita, A. L., Cherenko, M., Smythe, C., de Rooij, T. M., Cools, M., Danne, T., Katugampola, H., Dekkers, O. M., Hiort, O., Linglart, A., Netchine, I., Nordenstrom, A., Attila, P., Persani, L., Reisch, N., Smyth, A., Sumnik, Z., Taruscio, D., Visser, W. E., Pereira, A. M., Appelman-Dijkstra, N. M., Ahmed, S. F., Ali, S. R., Bryce, J., Priego-Zurita, A. L., Cherenko, M., Smythe, C., de Rooij, T. M., Cools, M., Danne, T., Katugampola, H., Dekkers, O. M., Hiort, O., Linglart, A., Netchine, I., Nordenstrom, A., Attila, P., Persani, L., Reisch, N., Smyth, A., Sumnik, Z., Taruscio, D., Visser, W. E., Pereira, A. M., Appelman-Dijkstra, N. M., and Ahmed, S. F.

Abstract

Objective: The European Registries for Rare Endocrine Conditions (EuRRECa, eurreb. eu) includes an e-reporting registry (e-REC) used to perform surveillance of conditions within the European Reference Network (ERN) for rare endocrine conditions (Endo-ERN). The aim of this study was to report the experience of e-REC over the 3.5 years since its launch in 2018. Methods: Electronic reporting capturing new encounters of Endo-ERN conditions was performed monthly through a bespoke platform by clinicians registered to participate in e-REC from July 2018 to December 2021. Results: The number of centres reporting on e-REC increased to a total of 61 centres from 22 countries. A median of 29 (range 11, 45) paediatric and 32 (14, 51) adult centres had reported cases monthly. A total of 9715 and 4243 new cases were reported in adults (age ≥18 years) and children, respectively. In children, sex development conditions comprised 40% of all reported conditions and transgender cases were most frequently reported, comprising 58% of sex development conditions. The median number of sex development cases reported per centre per month was 0.6 (0, 38). Amongst adults, pituitary conditions comprised 44% of reported conditions and pituitary adenomas (69% of cases) were most commonly reported. The median number of pituitary cases reported per centre per month was 4 (0.4, 33). Conclusions: e-REC has gained increasing acceptability over the last 3.5 years for capturing brief information on new encounters of rare conditions and shows wide variations in the rate of presentation of these conditions to centres within a reference network. Significance statement Endocrinology includes a very wide range of rare conditions and their occurrence is often difficult to measure. By using an electronic platform that allowed monthly reporting of new clinical encounters of several rare endocrine conditions within a defined network that consisted of several reference centres in Europe, the EuRRECa project sh

Published
2023

3. LiMeS-Lab: An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors

Author

Tanke, V. F.B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G.J., van Dommelen, J. A.W., van Eck, H. J.N., Geers, M. G.D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H.M., Vernimmen, J. W.M., Vos, E. G.P., Morgan, T. W., Tanke, V. F.B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G.J., van Dommelen, J. A.W., van Eck, H. J.N., Geers, M. G.D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H.M., Vernimmen, J. W.M., Vos, E. G.P., and Morgan, T. W.

Abstract

The liquid metal shield laboratory (LiMeS-Lab) will provide the infrastructure to develop, test, and compare liquid metal divertor designs for future fusion reactors. The main research topics of LiMeS-lab will be liquid metal interactions with the substrate material of the divertor, the continuous circulation and capillary refilling of the liquid metal during intense plasma heat loading and the retention of plasma particles in the liquid metal. To facilitate the research, four new devices are in development at the Dutch Institute for Fundamental Energy Research and the Eindhoven University of Technology: LiMeS-AM: a custom metal 3D printer based on powder bed fusion; LiMeS-Wetting, a plasma device to study the wetting of liquid metals on various substrates with different surface treatments; LiMeS-PSI, a linear plasma generator specifically adapted to operate continuous liquid metal loops. Special diagnostic protection will also be implemented to perform measurements in long duration shots without being affected by the liquid metal vapor; LiMeS-TDS, a thermal desorption spectroscopy system to characterize deuterium retention in a metal vapor environment. Each of these devices has specific challenges due to the presence and deposition of metal vapors that need to be addressed in order to function. In this paper, an overview of LiMeS-Lab will be given and the conceptual designs of the last three devices will be presented.

Published
2023

6. Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., Buchler M. W., Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., and Buchler M. W.

Abstract

Background: The aim was to evaluate the various operative techniques and outcomes used to manage the pancreatic transection plane (or stump) during a left (distal) pancreatectomy and to develop expert consensus guidelines. Methods: Evidence-based, clinically relevant questions were discussed and then were circulated among members of the International Study Group of Pancreatic Surgery. After agreement on the questions and statements, voting in a 9-point Likert scale was used to gauge the level of objective support for each. Results: Studies using the International Study Group of Pancreatic Surgery definition of postoperative pancreatic fistula including 16 randomized trials were reviewed to generate a series of statements set into 14 domains. There was strong consensus in the following statements: there was no difference in the postoperative pancreatic fistula rate after left pancreatectomy between the handsewn and stapler techniques; a stapling technique could not be used in all cases of left pancreatectomy; the use of an energy-based tissue sealant or a chemical sealant device or combinations of these did not impact the postoperative pancreatic fistula rate; there was no difference in the postoperative pancreatic fistula rate between the open, laparoscopic, or robotic approaches; and there are 1 or more clinically important, patient-related risk factors associated with the postoperative pancreatic fistula rate. There was weak or conditional agreement on the use of prophylactic somatostatin analogs, stents, stump closure, stump anastomosis, and the role of abdominal drains. Conclusion: Areas of strong consensus suggests a change in clinical practice and priority setting. Eight domains with lower agreement will require novel approaches and large multicenter studies to determine future key areas of practice.

Published
2020

7. Outcomes of a Multicenter Training Program in Robotic Pancreatoduodenectomy (LAELAPS-3)

Author

Zwart, M.J.W., Nota, C.L.M., Rooij, T. de, Hilst, J. van, Riele, W.W. te, Santvoort, H.C. van, Hagendoorn, J., Rinkes, I.H.M.B., Dam, J.L. van, Latenstein, A.E.J., Takagi, K., Tran, K.T.C., Schreinemakers, J., Schelling, G.P. van der, Wijsman, J.H., Festen, S., Daams, F., Luyer, M.D., Hingh, I.H.J.T. de, Mieog, J.S.D., Bonsing, B.A., Lips, D.J., Abu Hilal, M., Busch, O.R., Saint-Marc, O., Zehl, H.J.Z., Zureikat, A.H., Hogg, M.E., Molenaar, I.Q., Besselink, M.G., Koerkamp, B.G., Dutch Pancreatic Canc Grp, Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Anesthesiology, APH - Quality of Care, Surgery, CCA - Cancer Treatment and quality of life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
complication, Robotics, Pancreaticoduodenectomy, Pancreatic Neoplasms, Pancreatic Fistula, Postoperative Complications, learning curve, robotic pancreatoduodectomy, Robotic Surgical Procedures, SDG 3 - Good Health and Well-being, robotic surgery, Humans, Laparoscopy, Surgery, Retrospective Studies, operative time
Abstract

OBJECTIVE: To assess feasibility and safety of a multicenter training program in robotic pancreatoduodenectomy (RPD) adhering to the IDEAL framework for implementation of surgical innovation.BACKGROUND: Good results for RPD have been reported from single center studies. However, data on feasibility and safety of implementation through a multicenter training program in RPD are lacking.METHODS: A multicenter training program in RPD was designed together with the University of Pittsburgh Medical Center, including an online video bank, robot simulation exercises, biotissue drills, and on-site proctoring. Benchmark patients were based on the criteria of Clavien. Outcomes were collected prospectively (March 2016-October 2019). Cumulative sum (CUSUM) analysis of operative time was performed to distinguish the first and second phase of the learning curve. Outcomes were compared between both phases of the learning curve. Trends in nationwide use of robotic and laparoscopic PD were assessed in the Dutch Pancreatic Cancer Audit.RESULTS: Overall, 275 RPD procedures were performed in seven centers by 15 trained surgeons. The recent benchmark criteria for low-risk PD were met by 125 (45.5%) patients. The conversion rate was 6.5% (n = 18) and median blood loss 250 ml (IQR 150-500). The rate of Clavien-Dindo grade ≥III complications was 44.4% (n = 122), postoperative pancreatic fistula (grade B/C) rate 23.6% (n = 65), 90-day complication-related mortality 2.5% (n = 7) and 90-day cancer-related mortality 2.2.% (n = 6). Median postoperative hospital stay was 12 days (IQR 8-20). In the subgroup of patients with pancreatic cancer (n = 80), the major complication rate was 31.3% and POPF rate was 10%. CUSUM analysis for operative time found a learning curve inflection point at 22 RPDs (IQR 10-35) with similar rates of Clavien-Dindo grade ≥III complications in the first and second phase (43.4% vs 43.8%, P = 0.956, respectively). During the study period the nationwide use of laparoscopic PD reduced from 15% to 1%, whereas the use of RPD increased from 0% to 25%.CONCLUSIONS: This multicenter RPD training program in centers with sufficient surgical volume was found to be feasible without a negative impact of the learning curve on clinical outcomes.

Published
2021

8. Performance with robotic surgery versus 3D- and 2D-laparoscopy during pancreatic and biliary anastomoses in a biotissue model: pooled analysis of two randomized trials

Author

Zwart, M.J., Jones, L.R., Fuente, I., Balduzzi, A., Takagi, K., Novak, S., Stibbe, L.A., Rooij, T. de, Hilst, J. van der, Rijssen, L.B. van, Dieren, S. van, Vanlander, A., Boezem, P.B. van den, Daams, F., Mieog, J.Sven D., Bonsing, B.A., Rosman, C., Festen, S., Luyer, M.D., Lips, D.J., Moser, A.J., Busch, O.R., Hilal, M. Abu, Hogg, M.E., Stommel, M.W.J., Besselink, Marc G., Zwart, M.J., Jones, L.R., Fuente, I., Balduzzi, A., Takagi, K., Novak, S., Stibbe, L.A., Rooij, T. de, Hilst, J. van der, Rijssen, L.B. van, Dieren, S. van, Vanlander, A., Boezem, P.B. van den, Daams, F., Mieog, J.Sven D., Bonsing, B.A., Rosman, C., Festen, S., Luyer, M.D., Lips, D.J., Moser, A.J., Busch, O.R., Hilal, M. Abu, Hogg, M.E., Stommel, M.W.J., and Besselink, Marc G.

Abstract

Contains fulltext : 251550.pdf (Publisher’s version ) (Open Access), BACKGROUND: Robotic surgery may improve surgical performance during minimally invasive pancreatoduodenectomy as compared to 3D- and 2D-laparoscopy but comparative studies are lacking. This study assessed the impact of robotic surgery versus 3D- and 2D-laparoscopy on surgical performance and operative time using a standardized biotissue model for pancreatico- and hepatico-jejunostomy using pooled data from two randomized controlled crossover trials (RCTs). METHODS: Pooled analysis of data from two RCTs with 60 participants (36 surgeons, 24 residents) from 11 countries (December 2017-July 2019) was conducted. Each included participant completed two pancreatico- and two hepatico-jejunostomies in biotissue using 3D-robotic surgery, 3D-laparoscopy, or 2D-laparoscopy. Primary outcomes were the objective structured assessment of technical skills (OSATS: 12-60) rating, scored by observers blinded for 3D/2D and the operative time required to complete both anastomoses. Sensitivity analysis excluded participants with excess experience compared to others. RESULTS: A total of 220 anastomoses were completed (robotic 80, 3D-laparoscopy 70, 2D-laparoscopy 70). Participants in the robotic group had less surgical experience [median 1 (0-2) versus 6 years (4-12), p < 0.001], as compared to the laparoscopic group. Robotic surgery resulted in higher OSATS ratings (50, 43, 39 points, p = .021 and p < .001) and shorter operative time (56.5, 65.0, 81.5 min, p = .055 and p < .001), as compared to 3D- and 2D-laparoscopy, respectively, which remained in the sensitivity analysis. CONCLUSION: In a pooled analysis of two RCTs in a biotissue model, robotic surgery resulted in better surgical performance scores and shorter operative time for biotissue pancreatic and biliary anastomoses, as compared to 3D- and 2D-laparoscopy.

Published
2022

9. Long-term survival and secondary procedures after open or endovascular repair of abdominal aortic aneurysms

Author

van Schaik, Theodorus G., Yeung, Kak K., Verhagen, Hence J., de Bruin, Jorg L., van Sambeek, Marc R.H.M., Balm, Ron, Zeebregts, Clark J., van Herwaarden, Joost A., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A.A., Buth, J., Pattynama, P. M., Verhoeven, E. L.G., van Voorthuisen, A. E., Balm, R., Cuypers, P. W.M., Prinssen, M., van Sambeek, M. R.H.M., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J.H.M., de Mol, B. A.J.M., van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., de Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., van der Ham, A. C., van der Velden, J. J.I.M., van Sterkenburg, S. M.M., ten Haken, G. B., Bruijninckx, C. M.A., van Overhagen, H., Nolthenius, Tutein R.P., Hendriksz, T. R., Teijink, J. A.W., Odink, H. F., de Smet, A. A.E.A., Vroegindeweij, D., van Loenhout, R. M.M., Rutten, M. J., Hamming, J. F., Lampmann, L. E.H., Bender, M. H.M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J.C., van Dortmont, L. M.C., van der Vliet, A. J., Kool, Schultze L.J., Boomsma, J. H.B., van Dop, H. R., de Mol van Otterloo, J. C.A., de Rooij, T. P.W., Smits, T. M., Yilmaz, E. N., van den Berg, F. G., Visser, M. J.T., van der Linden, E., Schurink, G. W.H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., and Vermassen, F. E.G.

Published
2017
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10. Meta‐analysis of individual‐patient data from EVAR‐1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years

Author

Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J.‐P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D. G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R.J., Bell, P. R. F., Greenhalgh, R. M., Whitaker, S.C., Poole‐Wilson, the late P.A., Ruckley, C. V., Campbell, W. B., Dean, M. R. E., Ruttley, M. S. T., Coles, E. C., Powell, J. T., Halliday, A., Gibbs, S. J., Brown, L. C., Epstein, D., Sculpher, M. J., Thompson, S. G., Hannon, R. J., Johnston, L., Bradbury, A. W., Henderson, M. J., Parvin, S. D., Shepherd, D. F. C., Greenhalgh, R. M., Mitchell, A. W., Edwards, P. R., Abbott, G. T., Higman, D. J., Vohra, A., Ashley, S., Robottom, C., Wyatt, M. G., Rose, J. D. G., Byrne, D., Edwards, R., Leiberman, D. P., McCarter, D. H., Taylor, P. R., Reidy, J. F., Wilkinson, A. R., Ettles, D. F., Clason, A. E., Leen, G. L. S., Wilson, N. V., Downes, M., Walker, S. R., Lavelle, J. M., Gough, M. J., McPherson, S., Scott, D. J. A., Kessell, D. O., Naylor, R., Sayers, R., Fishwick, N. G., Harris, P. L., Gould, D. A., Walker, M. G., Chalmers, N. C., Garnham, A., Collins, M. A., Beard, J. D., Gaines, P. A., Ashour, M. Y., Uberoi, R., Braithwaite, B., Whitaker, S. C., Davies, J. N., Travis, S., Hamilton, G., Platts, A., Shandall, A., Sullivan, B. A., Sobeh, M., Matson, M., Fox, A. D., Orme, R., Yusef, W., Doyle, T., Horrocks, M., Hardman, J., Blair, P. H. B., Ellis, P. K., Morris, G., Odurny, A., Vohra, R., Duddy, M., Thompson, M., Loosemore, T. M. L., Belli, A. M., Morgan, R., Adiseshiah, M., Brookes, J. A. S., McCollum, C. N., Ashleigh, R., Aukett, M., Baker, S., Barbe, E., Batson, N., Bell, J., Blundell, J., Boardley, D., Boyes, S., Brown, O., Bryce, J., Carmichael, M., Chance, T., Coleman, J., Cosgrove, C., Curran, G., Dennison, T., Devine, C., Dewhirst, N., Errington, B., Farrell, H., Fisher, C., Fulford, P., Gough, M., Graham, C., Hooper, R., Horne, G., Horrocks, L., Hughes, B., Hutchings, T., Ireland, M., Judge, C., Kelly, L., Kemp, J., Kite, A., Kivela, M., Lapworth, M., Lee, C., Linekar, L., Mahmood, A., March, L., Martin, J., Matharu, N., McGuigen, K., Morris‐Vincent, P., Murray, S., Murtagh, A., Owen, G., Ramoutar, V., Rippin, C., Rowley, J., Sinclair, J., Spencer, S., Taylor, V., Tomlinson, C., Ward, S., Wealleans, V., West, J., White, K., Williams, J., Wilson, L., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A. A., Buth, J., Pattynama, P. M., Verhoeven, E. L. G., van Voorthuisen, A. E., Blankensteijn, J. D., Balm, R., Buth, J., Cuypers, P. W. M., Grobbee, D. E., Prinssen, M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J. H. M., de Mol, B. A. J. M., van Bockel, J. H., Balm, R., Reekers, J., Tielbeek, X., Verhoeven, E. L. G., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., Prinssen, M., Balm, R., Blankensteijn, J. D., Buth, J., Cuypers, P. W. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., de Bruin, J. L., Baas, A. F., Blankensteijn, J. D., Prinssen, M., Buth, J., Tielbeek, A.V., Blankensteijn, J. D., Balm, R., Reekers, J. A., van Sambeek, M. R. H. M., Pattynama, P., Verhoeven, E. L. G., Prins, T., van der Ham, A. C., van der Velden, J. J. I. M., van Sterkenburg, S. M. M., ten Haken, G. B., Bruijninckx, C. M. A., van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A. W., Odink, H. F., de Smet, A. A. E. A., Vroegindeweij, D., van Loenhout, R. M. M., Rutten, M. J., Hamming, J. F., Lampmann, L. E. H., Bender, M. H. M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J. C., van Dortmont, L. M. C., van der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H. B., van Dop, H. R., de Mol van Otterloo, J. C. A., de Rooij, T. P. W., Smits, T. M., Yilmaz, E. N., Wisselink, W., van den Berg, F. G., Visser, M. J. T., van der Linden, E., Schurink, G. W. H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., Vermassen, F. E. G., Lederle, F. A., Freischlag, J. A., Kohler, T. R., Latts, E., Matsumura, J., Padberg, F. T., Jr, Kyriakides, T. C., Swanson, K. M., Guarino, P., Peduzzi, P., Antonelli, M., Cushing, C., Davis, E., Durant, L., Joyner, S., Kossack, the late A., Kyriakides, T. C., LeGwin, Mary, McBride, V., OʼConnor, T., Poulton, J., Stratton, the late S., Zellner, S., Snodgrass, A. J., Thornton, J., Swanson, K. M., Haakenson, C. M., Stroupe, K.T., Jonk, Y., Hallett, J. W., Hertzer, N., Towne, J., Katz, D. A., Karrison, T., Matts, J. P., Marottoli, R., Kasl, S., Mehta, R., Feldman, R., Farrell, W., Allore, H., Perry, E., Niederman, J., Randall, F., Zeman, M., Beckwith, the late D., OʼLeary, T. J., Huang, G. D., Latts, E., Bader, M., Ketteler, E. R., Kingsley, D. D., Marek, J. M., Massen, R. J., Matteson, B. D., Pitcher, J. D., Langsfeld, M., Corson, J. D., Goff, J. M., Jr, Kasirajan, K., Paap, C., Robertson, D. C., Salam, A., Veeraswamy, R., Milner, R., Kasirajan, K., Guidot, J., Lal, B. K., Busuttil, S. J., Lilly, M. P., Braganza, M., Ellis, K., Patterson, M. A., Jordan, W. D., Whitley, D., Taylor, S., Passman, M., Kerns, D., Inman, C., Poirier, J., Ebaugh, J., Raffetto, J., Chew, D., Lathi, S., Owens, C., Hickson, K., Dosluoglu, H. H., Eschberger, K., Kibbe, M. R., Baraniewski, H. M., Matsumura, J., Endo, M., Busman, A., Meadows, W., Evans, M., Giglia, J. S., El Sayed, H., Reed, A. B., Ruf, M., Ross, S., Jean‐Claude, J. M., Pinault, G., Kang, P., White, N., Eiseman, M., Jones, the late R., Timaran, C. H., Modrall, J. G., Welborn, M. B., III, Lopez, J., Nguyen, T., Chacko, J. K. Y., Granke, K., Vouyouka, A. G., Olgren, E., Chand, P., Allende, B., Ranella, M., Yales, C., Whitehill, T. A., Krupski, the late W. C., Nehler, M. R., Johnson, S. P., Jones, D. N., Strecker, P., Bhola, M. A., Shortell, C. K., Gray, J. L., Lawson, J. H., McCann, R., Sebastian, M.W., Kistler Tetterton, J., Blackwell, C., Prinzo, P. A., Lee, N., Padberg, F. T., Jr, Cerveira, J. J., Lal, B. K., Zickler, R. W., Hauck, K. A., Berceli, S. A., Lee, W. A., Ozaki, C. K., Nelson, P. R., Irwin, A. S., Baum, R., Aulivola, B., Rodriguez, H., Littooy, F. N., Greisler, H., OʼSullivan, M. T., Kougias, P., Lin, P. H., Bush, R. L., Guinn, G., Bechara, C., Cagiannos, C., Pisimisis, G., Barshes, N., Pillack, S., Guillory, B., Cikrit, D., Lalka, S. G., Lemmon, G., Nachreiner, R., Rusomaroff, M., OʼBrien, E., Cullen, J. J., Hoballah, J., Sharp, W. J., McCandless, J. L., Beach, V., Minion, D., Schwarcz, T. H., Kimbrough, J., Ashe, L., Rockich, A., Warner‐Carpenter, J., Moursi, M., Eidt, J. F., Brock, S., Bianchi, C., Bishop, V., Gordon, I. L., Fujitani, R., Kubaska, S. M., III, Behdad, M., Azadegan, R., Ma Agas, C., Zalecki, K., Hoch, J. R., Carr, S. C., Acher, C., Schwarze, M., Tefera, G., Mell, M., Dunlap, B., Rieder, J., Stuart, J. M., Weiman, D. S., Abul‐Khoudoud, O., Garrett, H. E., Walsh, S. M., Wilson, K. L., Seabrook, G. R., Cambria, R. A., Brown, K. R., Lewis, B. D., Framberg, S., Kallio, C., Barke, R. A., Santilli, S. M., dʼAudiffret, A. C., Oberle, N., Proebstle, C., Johnson, L. L., Jacobowitz, G. R., Cayne, N., Rockman, C., Adelman, M., Gagne, P., Nalbandian, M., Caropolo, L. J., Pipinos, I. I., Johanning, J., Lynch, T., DeSpiegelaere, H., Purviance, G., Zhou, W., Dalman, R., Lee, J. T., Safadi, B., Coogan, S. M., Wren, S. M., Bahmani, D. D., Maples, D., Thunen, S., Golden, M. A., Mitchell, M. E., Fairman, R., Reinhardt, S., Wilson, M. A., Tzeng, E., Muluk, S., Peterson, N. M., Foster, M., Edwards, J., Moneta, G. L., Landry, G., Taylor, L., Yeager, R., Cannady, E., Treiman, G., Hatton‐Ward, S., Salabsky, the late B., Kansal, N., Owens, E., Estes, M., Forbes, B. A., Sobotta, C., Rapp, J. H., Reilly, L. M., Perez, S. L., Yan, K., Sarkar, R., Dwyer, S. S., Perez, S., Chong, K., Kohler, T. R., Hatsukami, T. S., Glickerman, D. G., Sobel, M., Burdick, T. S., Pedersen, K., Cleary, P., Back, M., Bandyk, D., Johnson, B., Shames, M., Reinhard, R. L., Thomas, S. C., Hunter, G. C., Leon, L. R., Jr, Westerband, A., Guerra, R. J., Riveros, M., Mills, J. L., Sr, Hughes, J. D., Escalante, A. M., Psalms, S. B., Day, N. N., Macsata, R., Sidawy, A., Weiswasser, J., Arora, S., Jasper, B. J., Dardik, A., Gahtan, V., Muhs, B. E., Sumpio, B. E., Gusberg, R. J., Spector, M., Pollak, J., Aruny, J., Kelly, E. L., Wong, J., Vasilas, P., Joncas, C., Gelabert, H. A., DeVirgillio, C., Rigberg, D. A., Cole, L., Becquemin, J.‐P., Marzelle, J., Becquemin, J.‐P., Sapoval, M., Becquemin, J.‐P., Favre, J.‐P., Watelet, J., Lermusiaux, P., Sapoval, M., Lepage, E., Hemery, F., Dolbeau, G., Hawajry, N., Cunin, P., Harris, P., Stockx, L., Chatellier, G., Mialhe, C., Fiessinger, J.‐N., Pagny, L., Kobeiter, H., Boissier, C., Lacroix, P., Ledru, F., Pinot, J.‐J., Deux, J.‐F., Tzvetkov, B., Duvaldestin, P., Watelet, J., Jourdain, C., David, V., Enouf, D., Ady, N., Krimi, A., Boudjema, N., Jousset, Y., Enon, B., Blin, V., Picquet, J., LʼHoste, P., Thouveny, F., Borie, H., Kowarski, S., Pernes, J.‐M., Auguste, M., Becquemin, J.‐P., Desgranges, P., Allaire, E., Marzelle, J., Kobeiter, H., Meaulle, P.‐Y., Chaix, D., Juliae, P., Fabiani, J. N., Chevalier, P., Combes, M., Seguin, A., Belhomme, D., Sapoval, M., Baque, J., Pellerin, O., Favre, J. P., Barral, X., Veyret, C., Watelet, J., Peillon, C., Plissonier, D., Thomas, P., Clavier, E., Lermusiaux, P., Martinez, R., Bleuet, F., C, Dupreix, Verhoye, J. P., Langanay, T., Heautot, J. F., Koussa, M., Haulon, S., Halna, P., Destrieux, L., Lions, C., Wiloteaux, S., Beregi, J. P., Bergeron, P., Pinot, J.‐J., Patra, P., Costargent, A., Chaillou, P., DʼAlicourt, A., Goueffic, Y., Cheysson, E., Parrot, A., Garance, P., Demon, A., Tyazi, A., Pillet, J.‐C., Lescalie, F., Tilly, G., Steinmetz, E., Favier, C., Brenot, R., Krause, D., Cercueil, J. P., Vahdat, O., Sauer, M., Soula, P., Querian, A., Garcia, O., Levade, M., Colombier, D., Cardon, J.‐M., Joyeux, A., Borrelly, P., Dogas, G., Magnan, P.‐É., Branchereau, A., Bartoli, J.‐M., Hassen‐Khodja, R., Batt, M., Planchard, P.‐F., Bouillanne, P.‐J., Haudebourg, P., Bayne, J., Gouny, P., Badra, A., Braesco, J., Nonent, M., Lucas, A., Cardon, A., Kerdiles, Y., Rolland, Y., Kassab, M., Brillu, C., Goubault, F., Tailboux, L., Darrieux, H., Briand, O., Maillard, J.‐C., Varty, K., and Cousins, C.

Published
2017
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11. Distal Fistula Risk Score (D-FRS): Design and Multicenter Internal-External Validation

Author

van Bodegraven, E., primary, De Pastena, M., additional, Mungroop, T., additional, Vissers, F., additional, Malleo, G., additional, Jones, L., additional, Alseidi, A., additional, Balduzzi, A., additional, de Rooij, T., additional, Seykora, T., additional, Paiella, S., additional, Klompmaker, S., additional, Marchegiani, G., additional, Trudeau, M., additional, van Eijck, C., additional, Koerkamp, B. Groot, additional, de Hingh, I., additional, Luyer, M., additional, Busch, O., additional, Salvia, R., additional, Steyerberg, E., additional, Hilal, M. Abu, additional, Vollmer, C., additional, Besselink, M., additional, and Bassi, C., additional

Published
2022
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13. Performance with robotic surgery versus 3D- and 2D-laparoscopy during pancreatic and biliary anastomoses in a biotissue model: Pooled analysis of two randomized trials

Author

Zwart, M., primary, Jones, L., additional, Fuente, I., additional, Balduzzi, A., additional, Takagi, K., additional, Novak, S., additional, Stibbe, L., additional, de Rooij, T., additional, van Hilst, J., additional, van Rijssen, B., additional, van Dieren, S., additional, Vanlander, A., additional, van den Boezem, P., additional, Daams, F., additional, Mieog, S., additional, Bonsing, B., additional, Rosman, C., additional, Festen, S., additional, Luyer, M., additional, Lips, D., additional, Moser, A., additional, Busch, O., additional, Hilal, M. Abu, additional, Hogg, M., additional, Stommel, M., additional, and Besselink, M., additional

Published
2021
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15. Minimally invasive versus open distal pancreatectomy: an individual patient data meta-analysis of two randomized controlled trials

Author

Korrel, M. (Maarten), Vissers, F.L. (Frederique L.), van Hilst, J. (Jony), de Rooij, T. (Thijs), Dijkgraaf, M.G.W. (Marcel), Festen, S. (Sebastiaan), Groot Koerkamp, B. (Bas), Busch, O.R.C. (Olivier), Luyer, M. (Misha), Sandström, P. (Per), Abu Hilal, M. (Mohammad), Besselink, M.G. (Marc), Björnsson, B. (Bergthor), Korrel, M. (Maarten), Vissers, F.L. (Frederique L.), van Hilst, J. (Jony), de Rooij, T. (Thijs), Dijkgraaf, M.G.W. (Marcel), Festen, S. (Sebastiaan), Groot Koerkamp, B. (Bas), Busch, O.R.C. (Olivier), Luyer, M. (Misha), Sandström, P. (Per), Abu Hilal, M. (Mohammad), Besselink, M.G. (Marc), and Björnsson, B. (Bergthor)

Abstract

Background: Minimally invasive distal pancreatectomy (MIDP) has been suggested to reduce postoperative outcomes as compared to open distal pancreatectomy (ODP). Recently, the first randomized controlled trials (RCTs) comparing MIDP to ODP were published. This individual patient data meta-analysis compared outcomes after MIDP versus ODP combining data from both RCTs. Methods: A systematic literature search was performed to identify RCTs on MIDP vs. ODP, and individual patient data were harmonized. Primary endpoint was the rate of major (Clavien-Dindo ≥ III) complications. Sensitivity analyses were performed in high-risk subgroups. Results: A total of 166 patients from the LEOPARD and LAPOP RCTs were included. The rate of major complications was 21% after MIDP vs. 35% after ODP (adjusted odds ratio 0.54; p = 0.148). MIDP significantly reduced length of hospital stay (6 vs. 8 days, p = 0.036), and delayed gastric emptying (4% vs. 16%, p = 0.049), as compared to ODP. A trend towards higher rates of postoperative pancreatic fistula was observed after MIDP (36% vs. 28%, p = 0.067). Outcomes were comparable in high-risk subgroups. Conclusion: This individual patient data meta-analysis showed that MIDP, when performed by trained surgeons, may be regarded as the preferred approach for distal pancreatectomy. Outcomes are improved after MIDP as compared to ODP, without obvious downsides in high-risk subgroups.

Published
2020
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16. Performance with Robotic Surgery versus 3D- and 2D-laparoscopy during Pancreatic and Biliary Anastomoses in a Biotissue Model: Pooled Analysis of Two Randomized Trials

Author

Zwart, M.J., primary, Jones, L.R., additional, Fuente, I., additional, Balduzzi, A., additional, Takagi, K., additional, Novak, S., additional, Stibbe, L., additional, de Rooij, T., additional, van Hilst, J., additional, van Rijssen, L.B., additional, van Dieren, S., additional, Vanlander, A., additional, van den Boezem, P.B., additional, Daams, F., additional, Mieog, J.S.D., additional, Bonsing, B.A., additional, Rosman, C., additional, Festen, S., additional, Luyer, M.D., additional, Lips, D.J., additional, Moser, A.J., additional, Busch, O.R., additional, Abu Hilal, M., additional, Hogg, M.E., additional, Stommel, M.W.J., additional, and Besselink, M.G., additional

Published
2021
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17. Outcomes of a multicenter training program in robotic pancreatoduodenectomy (LAELAPS-3)

Author

Zwart, M., primary, Nota, C., additional, De Rooij, T., additional, Van Hilst, J., additional, Te Riele, W., additional, Van Santvoort, H., additional, Hagendoorn, J., additional, Borel Rinkes, I., additional, Tran, K., additional, Schelling G., Van Der, additional, Wijsman, J., additional, Schreinemakers, J., additional, Festen, S., additional, Daams, F., additional, Luyer, M., additional, De Hingh, I., additional, Mieog, S., additional, Bonsing, B., additional, Lips, D., additional, Abu Hilal, M., additional, Busch, O., additional, Saint-Marc, O., additional, Zeh, H., additional, Zureikat, A., additional, Hogg, M., additional, Molenaar, Q., additional, Besselink, M., additional, and Groot Koerkamp, B., additional

Published
2020
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18. Minimally Invasive versus Open Distal Pancreatectomy: An Individual Patient Data Meta-Analysis of Two Randomized Controlled Trials

Author

Korrel, M., primary, Vissers, F., additional, Van Hilst, J., additional, De Rooij, T., additional, Dijkgraaf, M., additional, Festen, S., additional, Groot Koerkamp, B., additional, Busch, O., additional, Luyer, M., additional, Sandström, P., additional, Abu Hilal, M., additional, Besselink, M., additional, and Björnsson, B., additional

Published
2020
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19. Added value of 3D-vision during laparoscopic biotissue pancreatico- and hepaticojejunostomy (LAELAPS 3D2D): an international randomized cross-over trial

Author

Zwart, M., primary, Fuente, I., additional, Van Hilst, J., additional, De Rooij, T., additional, Van Dieren, S., additional, Van Rijssen, L., additional, Schijven, M., additional, Busch, O., additional, Luyer, M., additional, Lips, D., additional, Festen, S., additional, Hilal, M., additional, and Besselink, M., additional

Published
2020
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20. A nationwide training program for robotic pancreatoduodenectomy (LAELAPS-3): analysis of the first trained surgeons and first 87 patients

Author

Zwart, M., primary, De Rooij, T., additional, Van hilst, J., additional, Stommel, M., additional, Van den Boezem, P., additional, Wijsman, J., additional, Van der Schelling, G., additional, Schreinemakers, J., additional, Daams, F., additional, Zonderhuis, B., additional, Kazemier, G., additional, Mieog, S., additional, Vahrmeijer, A., additional, Swijnenburg, R., additional, Bonsing, B., additional, Besselink, M., additional, Koerkamp, B Groot, additional, and DPCG, For the, additional

Published
2020
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23. The inflammatory response after laparoscopic and open pancreatoduodenectomy and the association with complications in a multicenter randomized controlled trial

Author

Van Hilst, J., primary, Brinkman, D., additional, De Rooij, T., additional, Van Dieren, S., additional, Gerhards, M., additional, De Hingh, I., additional, Luyer, M., additional, Marsman, H., additional, Karsten, T., additional, Busch, O., additional, Festen, S., additional, Heger, M., additional, and Besselink, M., additional

Published
2020
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24. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., van Santvoort, H. C., de Boer, M. T., Boerma, D., van den Boezem, P. B., van Dam, R. M., Dejong, C. H., van Duyn, E. B., van Eijck, C. H., Gerhards, M. F., de Hingh, I. H., Kazemier, G., de Kleine, R. H., van Laarhoven, C. J., Patijn, G. A., Steenvoorde, P., Suker, M., Hilal, M. Abu, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), Surgery, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and quality of life, Epidemiology and Data Science, APH - Methodology, AGEM - Digestive immunity, and CCA - Cancer Treatment and Quality of Life

Subjects
Male, Cost effectiveness, SURGERY, Cost-Benefit Analysis, INTERNATIONAL STUDY-GROUP, OPEN ILEOCOLIC RESECTION, law.invention, BODY-IMAGE, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Postoperative Complications, 0302 clinical medicine, Robotic Surgical Procedures, Quality of life, Randomized controlled trial, law, Hospital Costs/statistics & numerical data, Outcome Assessment, Health Care, 80 and over, Single-Blind Method, Hospital Costs, Laparoscopy, Netherlands, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, Multicenter Study, Patient Satisfaction, 030220 oncology & carcinogenesis, Randomized Controlled Trial, Original Article, 030211 gastroenterology & hepatology, Female, Quality-Adjusted Life Years, Adult, medicine.medical_specialty, Pancreatectomy/economics, COSMESIS, 03 medical and health sciences, Outcome Assessment (Health Care), All institutes and research themes of the Radboud University Medical Center, Pancreatectomy, Patient satisfaction, medicine, Journal Article, Humans, Comparative Study, Aged, Laparoscopy/economics, business.industry, Cosmesis, Original Articles, Recovery of Function, Confidence interval, Surgery, Quality-adjusted life year, Postoperative Complications/economics, DEFINITION, Quality of Life, Robotic Surgical Procedures/economics, business, Follow-Up Studies
Abstract

Background Minimally invasive distal pancreatectomy decreases time to functional recovery compared with open distal pancreatectomy, but the cost-effectiveness and impact on disease-specific quality of life have yet to be established. Methods The LEOPARD trial randomized patients to minimally invasive (robot-assisted or laparoscopic) or open distal pancreatectomy in 14 Dutch centres between April 2015 and March 2017. Use of hospital healthcare resources, complications and disease-specific quality of life were recorded up to 1 year after surgery. Unit costs of hospital healthcare resources were determined, and cost-effectiveness and cost–utility analyses were performed. Primary outcomes were the costs per day earlier functional recovery and per quality-adjusted life-year. Results All 104 patients who had a distal pancreatectomy (48 minimally invasive and 56 open) in the trial were included in this study. Patients who underwent a robot-assisted procedure were excluded from the cost analysis. Total medical costs were comparable after laparoscopic and open distal pancreatectomy (mean difference €–427 (95 per cent bias-corrected and accelerated confidence interval €–4700 to 3613; P = 0·839). Laparoscopic distal pancreatectomy was shown to have a probability of at least 0·566 of being more cost-effective than the open approach at a willingness-to-pay threshold of €0 per day of earlier recovery, and a probability of 0·676 per additional quality-adjusted life-year at a willingness-to-pay threshold of €80 000. There were no significant differences in cosmetic satisfaction scores (median 9 (i.q.r. 5·75–10) versus 7 (4–8·75); P = 0·056) and disease-specific quality of life after minimally invasive (laparoscopic and robot-assisted procedures) versus open distal pancreatectomy. Conclusion Laparoscopic distal pancreatectomy was at least as cost-effective as open distal pancreatectomy in terms of time to functional recovery and quality-adjusted life-years. Cosmesis and quality of life were similar in the two groups 1 year after surgery.

Published
2019

25. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA)

Author

van Hilst, J, de Rooij, T, Klompmaker, S, Rawashdeh, M, Aleotti, F, Al-Sarireh, B, Alseidi, A, Ateeb, Z, Balzano, G, Berrevoet, F, Bjornsson, B, Boggi, U, Busch, Or, Butturini, G, Casadei, R, Del Chiaro, M, Chikhladze, S, Cipriani, F, van Dam, R, Damoli, I, van Dieren, S, Dokmak, S, Edwin, B, van Eijck, C, Fabre, Jm, Falconi, M, Farges, O, Fernandez-Cruz, L, Forgione, A, Frigerio, I, Fuks, D, Gavazzi, F, Gayet, B, Giardino, A, Koerkamp, Bg, Hackert, T, Hassenpflug, M, Kabir, I, Keck, T, Khatkov, I, Kusar, M, Lombardo, C, Marchegiani, G, Marshall, R, Menon, Kv, Montorsi, M, Orville, M, de Pastena, M, Pietrabissa, A, Poves, I, Primrose, J, Pugliese, R, Ricci, C, Roberts, K, Rosok, B, Sahakyan, Ma, Sanchez-Cabus, S, Sandstrom, P, Scovel, L, Solaini, L, Soonawalla, Z, Souche, Fr, Sutcliffe, Rp, Tiberio, Ga, Tomazic, A, Troisi, R, Wellner, U, White, S, Wittel, Ua, Zerbi, A, Bassi, C, Besselink, Mg, and Abu Hilal, M

Subjects
Male, robot-assisted, laparoscopic, Pancreatectomy, Postoperative Complications, Robotic Surgical Procedures, Humans, Minimally Invasive Surgical Procedures, distal pancreatectomy, Propensity Score, Aged, Neoplasm Staging, Retrospective Studies, Incidence, Carcinoma, Length of Stay, left pancreatectomy, minimally invasive, Pancreatic Ductal, Europe, Female, Laparoscopy, Pancreatic Neoplasms, Survival Rate, Treatment Outcome, Carcinoma, Pancreatic Ductal
Published
2019

26. Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD) A Multicenter Patient-blinded Randomized Controlled Trial

Author

Rooij, T. de, Hilst, Jony van, Santvoort, H.C. van, Boerma, Djamila, Boezem, P.B. van den, Daams, F., Laarhoven, C.J. van, Busch, Olivier R., Besselink, M., Rooij, T. de, Hilst, Jony van, Santvoort, H.C. van, Boerma, Djamila, Boezem, P.B. van den, Daams, F., Laarhoven, C.J. van, Busch, Olivier R., and Besselink, M.

Abstract

Item does not contain fulltext

Published
2019

27. Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial

Author

Hilst, J. van der, Rooij, T. de, Bosscha, K., Brinkman, D.J., Dieren, S. van, Dijkgraaf, M.G., Gerhards, M.F., Hingh, I.H. de, Karsten, T.M., Lips, D.J., Luyer, M.D., Busch, O.R., Geenen, E.J. van, Laarhoven, C.J.H.M. van, Goor, H. van, Radema, S.A., Laarhoven, H.W.M. van, Festen, S., Besselink, M.G., Hilst, J. van der, Rooij, T. de, Bosscha, K., Brinkman, D.J., Dieren, S. van, Dijkgraaf, M.G., Gerhards, M.F., Hingh, I.H. de, Karsten, T.M., Lips, D.J., Luyer, M.D., Busch, O.R., Geenen, E.J. van, Laarhoven, C.J.H.M. van, Goor, H. van, Radema, S.A., Laarhoven, H.W.M. van, Festen, S., and Besselink, M.G.

Abstract

Item does not contain fulltext, BACKGROUND: Laparoscopic pancreatoduodenectomy may improve postoperative recovery compared with open pancreatoduodenectomy. However, there are concerns that the extensive learning curve of this complex procedure could increase the risk of complications. We aimed to assess whether laparoscopic pancreatoduodenectomy could reduce time to functional recovery compared with open pancreatoduodenectomy. METHODS: This multicentre, patient-blinded, parallel-group, randomised controlled phase 2/3 trial was performed in four centres in the Netherlands that each do 20 or more pancreatoduodenectomies annually; surgeons had to have completed a dedicated training programme for laparoscopic pancreatoduodenectomy and have done 20 or more laparoscopic pancreatoduodenectomies before trial participation. Patients with a benign, premalignant, or malignant indication for pancreatoduodenectomy, without signs of vascular involvement, were randomly assigned (1:1) to undergo either laparoscopic or open pancreatoduodenectomy using a central web-based system. Randomisation was stratified for annual case volume and preoperative estimated risk of pancreatic fistula. Patients were blinded to treatment allocation. Analysis was done according to the intention-to-treat principle. The main objective of the phase 2 part of the trial was to assess the safety of laparoscopic pancreatoduodenectomy (complications and mortality), and the primary outcome of phase 3 was time to functional recovery in days, defined as all of the following: adequate pain control with only oral analgesia; independent mobility; ability to maintain more than 50% of the daily required caloric intake; no need for intravenous fluid administration; and no signs of infection (temperature <38.5 degrees C). This trial is registered with Trialregister.nl, number NTR5689. FINDINGS: Between May 13 and Dec 20, 2016, 42 patients were randomised in the phase 2 part of the trial. Two patients did not receive surgery and were excluded from analy

Published
2019

28. Laparoscopic pancreatoduodenectomy with open or laparoscopic reconstruction during the learning curve: a multicenter propensity score matched study

Author

Hilst, Jony van, Rooij, T. de, Boezem, P.B. van den, Bosscha, K., Busch, Olivier R., Duijvendijk, Peter van, Stommel, M.W., Daams, F., Besselink, M.G.H., Hilst, Jony van, Rooij, T. de, Boezem, P.B. van den, Bosscha, K., Busch, Olivier R., Duijvendijk, Peter van, Stommel, M.W., Daams, F., and Besselink, M.G.H.

Abstract

Item does not contain fulltext

Published
2019

29. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

Hilst, J. van, Strating, E.A., Rooij, T. de, Daams, F., Festen, S., Koerkamp, B.Groot, Boer, M.T. De, Laarhoven, C.J. van, Suker, M., Abu Hilal, M., Hilst, J. van, Strating, E.A., Rooij, T. de, Daams, F., Festen, S., Koerkamp, B.Groot, Boer, M.T. De, Laarhoven, C.J. van, Suker, M., and Abu Hilal, M.

Abstract

Contains fulltext : 204749.pdf (publisher's version ) (Open Access)

Published
2019

30. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators, Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., and on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators

Published
2019

31. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

van Hilst, J, Strating, EA, Rooij, T, Daams, F, Festen, S, Groot Koerkamp, B, Klaase, JM, Luyer, M, Dijkgraaf, MG, Besselink, MG, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, van Dam, RM, DeJong, CH, van Duyn, EB, van Eijck, Casper, Gerhards, MF, de Hingh, IH, Kazemier, G, de Kleine, R H, van Laarhoven, CJ, Patijn, GA, Steenvoorde, P, Suker, M, Abu Hilal, M, van Hilst, J, Strating, EA, Rooij, T, Daams, F, Festen, S, Groot Koerkamp, B, Klaase, JM, Luyer, M, Dijkgraaf, MG, Besselink, MG, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, van Dam, RM, DeJong, CH, van Duyn, EB, van Eijck, Casper, Gerhards, MF, de Hingh, IH, Kazemier, G, de Kleine, R H, van Laarhoven, CJ, Patijn, GA, Steenvoorde, P, Suker, M, and Abu Hilal, M

Published
2019

32. Outcomes of Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma in the Netherlands: A Nationwide Retrospective Analysis

Author

Rooij, T. de, Tol, J.A., Eijck, C.H. van, Boerma, D., Bonsing, B.A., Bosscha, K., Dam, R.M. van, Dijkgraaf, M.G., Gerhards, M.F., Goor, H. van, Harst, E. van der, Hingh, I.H. de, Kazemier, G., Klaase, J.M., Molenaar, I.Q., Patijn, G.A., Santvoort, H.C. van, Scheepers, J.J., Schelling, G.P. van der, Sieders, E., Busch, O.R., Besselink, M.G., Dutch Pancreatic Canc Grp, RS: FHML non-thematic output, MUMC+: MA Heelkunde (9), Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Clinical Research Unit, and CCA - Clinical Therapy Development

Subjects
Adult, Male, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Adenocarcinoma, 030230 surgery, Gastroenterology, 03 medical and health sciences, Pancreatectomy, 0302 clinical medicine, Internal medicine, medicine, Carcinoma, Humans, Neoplasm Invasiveness, Survival rate, Aged, Neoplasm Staging, Netherlands, Retrospective Studies, business.industry, Incidence, Cancer, Pancreatic Tumors, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Pancreaticoduodenectomy, digestive system diseases, Pancreatic Neoplasms, Survival Rate, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Oncology, 030220 oncology & carcinogenesis, Female, Lymphadenectomy, Surgery, business, Carcinoma, Pancreatic Ductal, Follow-Up Studies
Abstract

Contains fulltext : 168590.pdf (Publisher’s version ) (Open Access) BACKGROUND: Large multicenter series on outcomes and predictors of survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC) are scarce. METHODS: Adults who underwent DP for PDAC in 17 Dutch pancreatic centers between January 2005 and September 2013 were analyzed retrospectively. The primary outcome was survival, and predictors of survival were identified using Cox regression analysis. RESULTS: In total, 761 consecutive patients after DP were assessed, of whom 620 patients were excluded because of non-PDAC histopathology (n = 616) or a lack of data (n = 4), leaving a total of 141 patients included in the study [45 % (n = 63) male, mean age 64 years (SD = 10)]. Multivisceral resection was performed in 43 patients (30 %) and laparoscopic resection was performed in 7 patients (5 %). A major complication (Clavien-Dindo score of III or higher) occurred in 46 patients (33 %). Mean tumor size was 44 mm (SD 23), and histopathological examination showed 70 R0 resections (50 %), while 30-day and 90-day mortality was 3 and 6 %, respectively. Overall, 63 patients (45 %) received adjuvant chemotherapy. Median survival was 17 months [interquartile range (IQR) 13-21], with a median follow-up of 17 months (IQR 8-29). Cumulative survival at 1, 3 and 5 years was 64, 29, and 22 %, respectively. Independent predictors of worse postoperative survival were R1/R2 resection [hazard ratio (HR) 1.6, 95 % confidence interval (CI) 1.1-2.4], pT3/pT4 stage (HR 1.9, 95 % CI 1.3-2.9), a major complication (HR 1.7, 95 % CI 1.1-2.5), and not receiving adjuvant chemotherapy (HR 1.5, 95 % CI 1.0-2.3). CONCLUSION: Survival after DP for PDAC is poor and is related to resection margin, tumor stage, surgical complications, and adjuvant chemotherapy. Further studies should assess to what extent prevention of surgical complications and more extensive use of adjuvant chemotherapy can improve survival.

Published
2016

33. Minimally invasive pancreatic surgery: A stepwise nationwide introduction

Author

de Rooij, T., Besselink, Marc G. H., Busch, Olivier R. C., Abu Hilal, M., Luyer, M. D., Graduate School, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Treatment and quality of life, Besselink, M.G., Busch, O.R., Luyer, M.D., and Faculteit der Geneeskunde

Abstract

Thijs de Rooij doet onderzoek naar de landelijke introductie van minimaal-invasieve alvleesklierchirurgie. Hij richt zich met name op de alvleesklierstaartresectie en de pancreatoduodenectomie, twee procedures die met name uitgevoerd worden voor de behandeling van alvleesklierkanker. Hij bekijkt of een laparoscopische of robot-geassisteerde benadering voor dit type chirurgie van toegevoegde waarde zijn. In eerste instantie rolt hij onder intensieve begeleiding landelijke introductieprogramma’s uit en bekijkt hij of deze introductie veilig is verlopen. Hierna worden de uitkomsten vergeleken met de conventionele ‘open’ benadering voor alvleesklierchirurgie. Hij analyseert voornamelijk de operatieve uitkomsten, complicaties, opnameduur, kwaliteit van leven en kosten, onder andere in landelijke gerandomiseerd gecontroleerde studies.

Published
2018

34. Variation in hospital mortality after pancreatoduodenectomy is related to failure to rescue rather than major complications: a nationwide audit

Author

van Rijssen, L., primary, Zwart, M., additional, Van Dieren, S., additional, De Rooij, T., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Van Eijck, C., additional, Gerhards, M., additional, Gerritsen, J., additional, Van Der Harst, E., additional, De Hingh, I., additional, De Jong, K., additional, Kazemier, G., additional, Klaase, J., additional, Van Der Kolk, M., additional, van Laarhoven, C., additional, Luyer, M., additional, Molenaar, I., additional, Patijn, G., additional, Rupert, C., additional, Scheepers, J., additional, Van Der Schelling, G., additional, Vahrmeijer, A., additional, Busch, O., additional, Van Santvoort, H., additional, Groot Koerkamp, B., additional, and Besselink, M., additional

Published
2019
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35. Worldwide survey on opinions and use of minimally invasive pancreatic resection

Author

van Hilst, J., primary, de Rooij, T., additional, Hilal, M. Abu, additional, Asbun, H., additional, Barkun, J., additional, Boggi, U., additional, Busch, O., additional, Conlon, K., additional, Dijkgraaf, M., additional, Han, H., additional, Hansen, P., additional, Kendrick, M., additional, Montagnini, A., additional, Palanivelu, C., additional, Røsok, B., additional, Shrikhande, S., additional, Wakabayashi, G., additional, Zeh, H., additional, Vollmer, C., additional, Kooby, D., additional, and Besselink, M., additional

Published
2019
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36. Minimally invasive versus open distal pancreatectomy for ductal adenocarcinoma (DIPLOMA): a pan-European propensity score matched study

Author

van Hilst, J., primary, de Rooij, T., additional, Klompmaker, S., additional, Rawashdeh, M., additional, Aleotti, F., additional, Al-Sarireh, B., additional, Alseidi, A., additional, Ateeb, Z., additional, Balzano, G., additional, Berrevoet, F., additional, Björnsson, B., additional, Boggi, U., additional, Busch, O., additional, Butturini, G., additional, Casadei, R., additional, del Chiaro, M., additional, Cipriani, F., additional, van Dam, R., additional, Damoli, I., additional, Dokmak, S., additional, Edwin, B., additional, van Eijck, C., additional, Fabre, J., additional, Falconi, M., additional, Farges, O., additional, Fernández-Cruz, L., additional, Forgione, A., additional, Frigerio, I., additional, Fuks, D., additional, Gavazzi, F., additional, Gayet, B., additional, Giardino, A., additional, Groot Koerkamp, B., additional, Hackert, T., additional, Hassenpflug, M., additional, Kabir, I., additional, Keck, T., additional, Khatkov, I., additional, Klock, A., additional, Kusar, M., additional, Lombardo, C., additional, Marchegiani, G., additional, Marshall, R., additional, Menon, K., additional, Montorsi, M., additional, Nowbray, N., additional, Orville, M., additional, Pietrabissa, A., additional, Poves, I., additional, Primrose, J., additional, Pugliese, R., additional, Ricci, C., additional, Roberts, K., additional, Røsok, B., additional, Sahakyan, M., additional, Sánchez-Cabús, S., additional, Sandström, P., additional, Scovel, L., additional, Solaini, L., additional, Soonawalla, Z., additional, Souche, R., additional, Sutcliffe, R., additional, Tiberio, G., additional, Tomazic, A., additional, Troisi, R., additional, Wellner, U., additional, White, S., additional, Wittel, U., additional, Zerbi, A., additional, Bassi, C., additional, Besselink, M., additional, and Abu Hilal, M., additional

Published
2019
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37. A Nationwide Comparison of Laparoscopic and Open Distal Pancreatectomy for Benign and Malignant Disease

Author

Rooij, T. de, Jilesen, A.P., Boerma, D., Bonsing, B.A., Bosscha, K., Dam, R.M. van, Dieren, S. van, Dijkgraaf, M.G., Eijck, C.H. van, Gerhards, M.F., Goor, H. van, Harst, E. van der, Hingh, I.H. de, Kazemier, G., Klaase, J.M., Molenaar, I.Q., Dijkum, E.J.N. van, Patijn, G.A., Santvoort, H.C. van, Scheepers, J.J., Schelling, G.P. van der, Sieders, E., Vogel, J.A., Busch, O.R., Besselink, M.G., Dutch Pancreatic Canc Grp, Surgery, CCA - Innovative therapy, RS: NUTRIM - R2 - Gut-liver homeostasis, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Other departments, Amsterdam Public Health, Clinical Research Unit, Other Research, Graduate School, and 02 Surgical specialisms

Subjects
Adult, Male, medicine.medical_specialty, Attitude of Health Personnel, medicine.medical_treatment, Pancreatectomy, Postoperative Complications, Interquartile range, Medicine, Humans, Propensity Score, Aged, Netherlands, Surgeons, Intention-to-treat analysis, business.industry, General surgery, Pancreatic Diseases, Odds ratio, Length of Stay, Middle Aged, Pancreaticoduodenectomy, Surgery, Intention to Treat Analysis, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, Health Care Surveys, Propensity score matching, Cohort, Female, Laparoscopy, business, Cohort study, Abdominal surgery
Abstract

Item does not contain fulltext BACKGROUND: Cohort studies from expert centers suggest that laparoscopic distal pancreatectomy (LDP) is superior to open distal pancreatectomy (ODP) regarding postoperative morbidity and length of hospital stay. But the generalizability of these findings is unknown because nationwide data on LDP are lacking. STUDY DESIGN: Adults who had undergone distal pancreatectomy in 17 centers between 2005 and 2013 were analyzed retrospectively. First, all LDPs were compared with all ODPs. Second, groups were matched using a propensity score. Third, the attitudes of pancreatic surgeons toward LDP were surveyed. The primary outcome was major complications (Clavien-Dindo grade >/=III). RESULTS: Among 633 included patients, 64 patients (10%) had undergone LDP and 569 patients (90%) had undergone ODP. Baseline characteristics were comparable, except for previous abdominal surgery and mean tumor size. In the full cohort, LDP was associated with fewer major complications (16% vs 29%; p = 0.02) and a shorter median [interquartile range, IQR] hospital stay (8 days [7-12 days] vs 10 days [8-14 days]; p = 0.03). Of all LDPs, 33% were converted to ODP. Matching succeeded for 63 LDP patients. After matching, the differences in major complications (9 patients [14%] vs 19 patients [30%]; p = 0.06) and median [IQR] length of hospital stay (8 days [7-12 days] vs 10 days [8-14 days]; p = 0.48) were not statistically significant. The survey demonstrated that 85% of surgeons welcomed LDP training. CONCLUSIONS: Despite nationwide underuse and an impact of selection bias, outcomes of LDP seemed to be at least noninferior to ODP. Specific training is welcomed and could improve both the use and outcomes of LDP. 01 maart 2015

Published
2015

38. Variation in hospital mortality after pancreatoduodenectomy is related to failure to rescue rather than major complications: a nationwide audit

Author

Rijssen, L.B. van, Zwart, M.J., Dieren, S. van, Rooij, T. de, Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Gerritsen, J.J., Harst, E, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Kolk, B.M. van der, Laarhoven, C.J.H.M. van, Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Scheepers, J.J., Schelling, G.P. van der, Vahrmeijer, A.L., Busch, O.R., Santvoort, H.C. van, Koerkamp, B. Groot, Besselink, M.G.H., Rijssen, L.B. van, Zwart, M.J., Dieren, S. van, Rooij, T. de, Bonsing, B.A., Bosscha, K., Dam, R.M. van, Eijck, C.H. van, Gerhards, M.F., Gerritsen, J.J., Harst, E, Hingh, I.H. de, Jong, K.P. de, Kazemier, G., Klaase, J., Kolk, B.M. van der, Laarhoven, C.J.H.M. van, Luyer, M.D., Molenaar, I.Q., Patijn, G.A., Rupert, C.G., Scheepers, J.J., Schelling, G.P. van der, Vahrmeijer, A.L., Busch, O.R., Santvoort, H.C. van, Koerkamp, B. Groot, and Besselink, M.G.H.

Abstract

Item does not contain fulltext, BACKGROUND: In the mandatory nationwide Dutch Pancreatic Cancer Audit, rates of major complications and Failure to Rescue (FTR) after pancreatoduodenectomy between low- and high-mortality hospitals are compared, and independent predictors for FTR investigated. METHODS: Patients undergoing pancreatoduodenectomy in 2014 and 2015 in The Netherlands were included. Hospitals were divided into quartiles based on mortality rates. The rate of major complications (Clavien-Dindo >/=3) and death after a major complication (FTR) were compared between these quartiles. Independent predictors for FTR were identified by multivariable logistic regression analysis. RESULTS: Out of 1.342 patients, 391 (29%) developed a major complication and in-hospital mortality was 4.2%. FTR occurred in 56 (14.3%) patients. Mortality was 0.9% in the first hospital quartile (4 hospitals, 327 patients) and 8.1% in the fourth quartile (5 hospitals, 310 patients). The rate of major complications increased by 40% (25.7% vs 35.2%) between the first and fourth hospital quartile, whereas the FTR rate increased by 560% (3.6% vs 22.9%). Independent predictors of FTR were male sex (OR = 2.1, 95%CI 1.2-3.9), age >75 years (OR = 4.3, 1.8-10.2), BMI >/=30 (OR = 2.9, 1.3-6.6), histopathological diagnosis of periampullary cancer (OR = 2.0, 1.1-3.7), and hospital volume <30 (OR = 3.9, 1.6-9.6). CONCLUSIONS: Variations in mortality between hospitals after pancreatoduodenectomy were explained mainly by differences in FTR, rather than the incidence of major complications.

Published
2018

39. Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery

Author

Beekers, I. (Inés), Rooij, T. (Tom) van, Verweij, M.D. (Martin), Versluis, M. (Michel), Jong, N. (Nico) de, Trietsch, S.J. (Sebastiaan J.), Kooiman, K. (Klazina), Beekers, I. (Inés), Rooij, T. (Tom) van, Verweij, M.D. (Martin), Versluis, M. (Michel), Jong, N. (Nico) de, Trietsch, S.J. (Sebastiaan J.), and Kooiman, K. (Klazina)

Abstract

Ultrasound in the presence of gas-filled microbubbles can be used to enhance local uptake of drugs and genes. To study the drug delivery potential and its underlying physical and biological mechanisms, an in vitro vessel model should ideally include 3D cell culture, perfusion flow, and membranefree soft boundaries. Here, we propose an organ-on-a-chip microfluidic platform to study ultrasound-mediated drug delivery: the OrganoPlate. The acoustic propagation into the OrganoPlate was determined to assess the feasibility of controlled microbubble actuation, which is required to study the microbubble-cell interaction for drug delivery. The pressure field in the OrganoPlate was characterized non-invasively by studying experimentally the well-known response of microbubbles and by simulating the acoustic wave propagation in the system. Microbubble dynamics in the OrganoPlate were recorded with the Brandaris 128 ultrahigh speed camera (17 Mfps) and a control experiment was performed in an OptiCell, an in vitro monolayer cell culture chamber that is conventionally used to study ultrasound-mediated dr

Published
2018
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40. Minimally invasive versus open pancreatoduodenectomy (LEOPARD-2): Study protocol for a randomized controlled trial

Author

de Rooij, T. (Thijs), van Hilst, J. (Jony), Bosscha, K. (Koop), Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Hingh, I.H.J.T. (Ignace) de, Karsten, T.M. (Thomas), Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Santvoort, H.C. (Hjalmar) van, Tran, T.C.K. (T.C. Khé), Busch, O.R.C. (Olivier), Festen, S. (Sebastiaan), Besselink, M.G. (Marc), de Rooij, T. (Thijs), van Hilst, J. (Jony), Bosscha, K. (Koop), Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Hingh, I.H.J.T. (Ignace) de, Karsten, T.M. (Thomas), Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Santvoort, H.C. (Hjalmar) van, Tran, T.C.K. (T.C. Khé), Busch, O.R.C. (Olivier), Festen, S. (Sebastiaan), and Besselink, M.G. (Marc)

Abstract

Background: Data from observational studies suggest that minimally invasive pancreatoduodenectomy (MIPD) is superior to open pancreatoduodenectomy regarding intraoperative blood loss, postoperative morbidity, and length of hospital stay, without increasing total costs. However, several case-matched studies failed to demonstrate superiority of MIPD, and large registry studies from the USA even suggested increased mortality for MIPDs performed in low-volume (< 10 MIPDs annually) centers. Randomized controlled multicenter trials are lacking but clearly required. We hypothesize that time to functional recovery is shorter after MIPD compared with open pancreatoduodenectomy, even in an enhanced recovery setting. Methods/design: LEOPARD-2 is a randomized controlled, parallel-group, patient-blinded, multicenter, phase 2/3, superiority trial in centers that completed the Dutch Pancreatic Cancer Group LAELAPS-2 training program for laparoscopic pancreatoduodenectomy or LAELAPS-3 training program for robot-assisted pancreatoduodenectomy and have performed ≥ 20 MIPDs. A total of 136 patients with symptomatic benign, premalignant, or malignant disease will be randomly assigned to undergo minimally invasive or open pancreatoduodenectomy in an enhanc

Published
2018
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41. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

Rooij, T. de, Hilst, J. van, Vogel, J.A., Santvoort, H.C. van, Boer, M.T. de, Boerma, D., Boezem, P.B. van den, Bonsing, B.A., Bosscha, K., Coene, P.P., Daams, F., Dam, R.M. van, Dijkgraaf, M.G., Eijck, C.H. van, Festen, S., Gerhards, M.F., Koerkamp, B.G., Hagendoorn, J., Harst, E. van der, Hingh, I.H. de, Dejong, C.H., Kazemier, G., Klaase, J., Kleine, R.H. de, Laarhoven, C.J. van, Lips, D.J., Luyer, M.D., Molenaar, I.Q., Nieuwenhuijs, V.B., Patijn, G.A., Roos, D., Scheepers, J.J., Schelling, G.P. van der, Steenvoorde, P., Swijnenburg, R.J., Wijsman, J.H., Abu Hilal, M., Busch, O.R., Besselink, M.G., Dutch Pancreatic Canc Grp, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, Surgery, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Gut-liver homeostasis, CCA - Cancer Treatment and Quality of Life, Other departments, APH - Methodology, Clinical Research Unit, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Time Factors, medicine.medical_treatment, Cost-Benefit Analysis, Health Status, INTERNATIONAL STUDY-GROUP, Distal pancreatectomy, Medicine (miscellaneous), Administration, Oral, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Study Protocol, Eating, 0302 clinical medicine, Superiority Trial, Randomized controlled trial, Quality of life, Clinical Protocols, Robotic Surgical Procedures, law, SURGERY ISGPS, Pharmacology (medical), 030212 general & internal medicine, Hospital Costs, Laparoscopy, Netherlands, Pain Measurement, Analgesics, Pain, Postoperative, lcsh:R5-920, medicine.diagnostic_test, MALIGNANT-DISEASE, Robot-assisted, 3. Good health, Treatment Outcome, Research Design, 030220 oncology & carcinogenesis, Pancreatectomy, lcsh:Medicine (General), Cohort study, medicine.medical_specialty, LONG-TERM, BENIGN, Pancreatic surgery, DUCTAL ADENOCARCINOMA, PANCREATOSPLENECTOMY, CLINICAL-TRIAL, 03 medical and health sciences, Laparoscopic, medicine, Journal Article, Humans, IDEAL FRAMEWORK, Minimally invasive, business.industry, Recovery of Function, Pancreatic cancer, Surgery, Clinical trial, DEFINITION, Quality of Life, Observational study, business, Energy Intake
Abstract

Background Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. We hypothesize that time to functional recovery is shorter after MIDP compared with ODP even in an enhanced recovery setting. Methods LEOPARD is a randomized controlled, parallel-group, patient-blinded, multicenter, superiority trial in all 17 centers of the Dutch Pancreatic Cancer Group. A total of 102 patients with symptomatic benign, premalignant or malignant disease will be randomly allocated to undergo MIDP or ODP in an enhanced recovery setting. The primary outcome is time (days) to functional recovery, defined as all of the following: independently mobile at the preoperative level, sufficient pain control with oral medication alone, ability to maintain sufficient (i.e. >50%) daily required caloric intake, no intravenous fluid administration and no signs of infection. Secondary outcomes are operative and postoperative outcomes, including clinically relevant complications, mortality, quality of life and costs. Discussion The LEOPARD trial is designed to investigate whether MIDP reduces the time to functional recovery compared with ODP in an enhanced recovery setting. Trial registration Dutch Trial Register, NTR5188. Registered on 9 April 2015 Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1892-9) contains supplementary material, which is available to authorized users.

Published
2017

43. Additional value of 3d-vision during laparoscopic pancreatoduodenectomy bio tissue drills (LAELAPS 3D2D): A randomized controlled cross-over trial

Author

Zwart, M.J.W., primary, van Hilst, J., additional, Fuente, I.P., additional, de Rooij, T., additional, van Dieren, S., additional, van Rijssen, L.B., additional, Schijven, M.P., additional, Busch, O.R.C., additional, Luyer, M.D., additional, Lips, D.J., additional, Festen, S., additional, and Besselink, M.G.H., additional

Published
2018
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45. Microbubble Composition and Preparation for High-Frequency Contrast-Enhanced Ultrasound Imaging: In Vitro and in Vivo Evaluation

Author

Daeichin, V. (Verya), Rooij, T. (Tom) van, Skachkov, I. (Ilya), Ergin, B. (Bülent), Specht, P. (Patricia), Lima, A.A.P. (Alexandre ), Ince, C. (Can), Bosch, J.G. (Hans), Steen, A.F.W. (Ton) van der, Jong, N. (Nico) de, Kooiman, K. (Klazina), Daeichin, V. (Verya), Rooij, T. (Tom) van, Skachkov, I. (Ilya), Ergin, B. (Bülent), Specht, P. (Patricia), Lima, A.A.P. (Alexandre ), Ince, C. (Can), Bosch, J.G. (Hans), Steen, A.F.W. (Ton) van der, Jong, N. (Nico) de, and Kooiman, K. (Klazina)

Abstract

Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (>15 MHz) are available for contrast-enhanced ultrasound (CEUS) imaging. Moreover, the composition of the limited commercially available UCAs for high-frequency CEUS (hfCEUS) is largely unknown, while shell properties have been shown to be an important factor for their performance. The aim of our study was to produce UCAs in-house for hfCEUS. Twelve different UCA formulations A-L were made by either sonication or mechanical agitation. The gas core consisted of C4F10 and the main coating lipid was either 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC; A-F formulation) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC; G-L formulation). Mechanical agitation re

Published
2017
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46. Minimally invasive versus open distal pancreatectomy (LEOPARD): Study protocol for a randomized controlled trial

Author

de Rooij, T. (Thijs), van Hilst, J. (Jony), Vogel, J.A. (Jantien A.), van Santvoort, H.C. (Hjalmar C.), Boer, M.T. (Marieke) de, Boerma, D. (Djamila), Boezem, P.B. van den, Bonsing, B.A. (Bert), Bosscha, K. (Koop), Coene, P-P. (Peter Paul), Daams, F. (Freek), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Eijck, C.H.J. (Casper) van, Festen, S. (Sebastiaan), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Dejong, C.H. (Cees), Kazemier, G. (Geert), Klaase, J.M. (Joost), Kleine, R.H.J. (Ruben) de, Laarhoven, C.J. (Cees) van, Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Nieuwenhuijs, V.B. (Vincent), Patijn, G.A. (Gijs A.), Roos, D. (Daphne), Scheepers, J.J. (Joris J.), Schelling, G. van der, Steenvoorde, P. (Pascal), Swijnenburg, R.-J. (Rutger-Jan), Wijsman, J.H.H. (Jan), Abu Hilal, M., Busch, O.R.C. (Olivier), Besselink, M.G. (Marc), de Rooij, T. (Thijs), van Hilst, J. (Jony), Vogel, J.A. (Jantien A.), van Santvoort, H.C. (Hjalmar C.), Boer, M.T. (Marieke) de, Boerma, D. (Djamila), Boezem, P.B. van den, Bonsing, B.A. (Bert), Bosscha, K. (Koop), Coene, P-P. (Peter Paul), Daams, F. (Freek), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Eijck, C.H.J. (Casper) van, Festen, S. (Sebastiaan), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Dejong, C.H. (Cees), Kazemier, G. (Geert), Klaase, J.M. (Joost), Kleine, R.H.J. (Ruben) de, Laarhoven, C.J. (Cees) van, Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Nieuwenhuijs, V.B. (Vincent), Patijn, G.A. (Gijs A.), Roos, D. (Daphne), Scheepers, J.J. (Joris J.), Schelling, G. van der, Steenvoorde, P. (Pascal), Swijnenburg, R.-J. (Rutger-Jan), Wijsman, J.H.H. (Jan), Abu Hilal, M., Busch, O.R.C. (Olivier), and Besselink, M.G. (Marc)

Abstract

Background: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. We hypothesize that time to functional recovery is shorter after MIDP compared with ODP even in an enhanced recovery setting. Methods: LEOPARD is a randomized controlled, parallel-group, patient-blinded, multicenter, superiority trial in all 17 centers of the Dutch Pancreatic Cancer Group. A total of 102 patients with symptomatic benign, premalignant or malignant disease will be randomly allocated to undergo MIDP or ODP in an enhanced recovery setting. The primary outcome is time (days) to functional recovery, defined as all of the following: independently mobile at the preoperative level, sufficient pain control with oral medication alone, ability to maintain sufficient (i.e. >50%) daily required caloric intake, no intravenous fluid administration and no signs of infection. Secondary outcomes are operative and postoperative outcomes, including clinically relevant complications, mortality, quality of life and costs. Discussion: The LEOPARD trial is designed to investigate whether MIDP reduces the time to functional recovery compared with ODP in an enhanced recovery setting. Trial registration: Dutch Trial Register, NTR5188. Registered on 9 April 2015

Published
2017
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47. Ultrasound Contrast Agents for Imaging and Therapy

Author

Rooij, T. (Tom) van and Rooij, T. (Tom) van

Abstract

The aim of this thesis is to unravel the relation between shell properties and the acoustic response of single microbubbles. Next, the most stable and acoustically best performing UCAs are also investigated in vitro for therapeutic applications by means of sonoporation, and for in vivo diagnostic imaging applications.

Published
2017

48. Laparoscopic surgery for pancreatic neoplasms: the European association for endoscopic surgery clinical consensus conference

Author

Edwin, B, Sahakyan, M, Abu Hilal, M, Besselink, M, Braga, M, Fabre, J, Fernández-Cruz, L, Gayet, B, Kim, S, Khatkov, I, Baichorov, M, De Rooij, T, Genç, C, Haugvik, S, Izrailov, R, Khisamov, A, Sánchez-Cabús, S, Souche, R, Van Hilst, J, Edwin, Bjørn, Sahakyan, Mushegh A., Abu Hilal, Mohammad, Besselink, Marc G., Braga, Marco, Fabre, Jean-Michel, Fernández-Cruz, Laureano, Gayet, Brice, Kim, Song Cheol, Khatkov, Igor E., Baichorov, Magomet E., De Rooij, Thijs, Genç, Cansu G., Haugvik, Sven-Petter, Izrailov, Roman E., Khisamov, Arthur A., Sánchez-Cabús, Santiago, Souche, Régis, Van Hilst, Jony, Edwin, B, Sahakyan, M, Abu Hilal, M, Besselink, M, Braga, M, Fabre, J, Fernández-Cruz, L, Gayet, B, Kim, S, Khatkov, I, Baichorov, M, De Rooij, T, Genç, C, Haugvik, S, Izrailov, R, Khisamov, A, Sánchez-Cabús, S, Souche, R, Van Hilst, J, Edwin, Bjørn, Sahakyan, Mushegh A., Abu Hilal, Mohammad, Besselink, Marc G., Braga, Marco, Fabre, Jean-Michel, Fernández-Cruz, Laureano, Gayet, Brice, Kim, Song Cheol, Khatkov, Igor E., Baichorov, Magomet E., De Rooij, Thijs, Genç, Cansu G., Haugvik, Sven-Petter, Izrailov, Roman E., Khisamov, Arthur A., Sánchez-Cabús, Santiago, Souche, Régis, and Van Hilst, Jony

Abstract

Background: Introduced more than 20 years ago, laparoscopic pancreatic surgery (LAPS) has not reached a uniform acceptance among HPB surgeons. As a result, there is no consensus regarding its use in patients with pancreatic neoplasms. This study, organized by the European Association for Endoscopic Surgery (EAES), aimed to develop consensus statements and clinical recommendations on the application of LAPS in these patients. Methods: An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open pancreatic surgery. Each panelist performed a critical appraisal of the literature and prepared evidence-based statements assessed by other panelists during Delphi process. The statements were further discussed during a one-day face-to-face meeting followed by the second round of Delphi. Modified statements were presented at the plenary session of the 24th International Congress of the EAES in Amsterdam and in a web-based survey. Results: LAPS included laparoscopic distal pancreatectomy (LDP), pancreatoduodenectomy (LPD), enucleation, central pancreatectomy, and ultrasound. In general, LAPS was found to be safe, especially in experienced hands, and also advantageous over an open approach in terms of intraoperative blood loss, postoperative recovery, and quality of life. Eighty-five percent or higher proportion of responders agreed with the majority (69.5%) of statements. However, the evidence is predominantly based on retrospective case–control studies and systematic reviews of these studies, clearly affected by selection bias. Furthermore, no randomized controlled trials (RCTs) have been published to date, although four RCTs are currently underway in Europe. Conclusions: LAPS is currently in its development and exploration stages, as defined by the international IDEAL framework for surgical innovation. LDP is feasible and safe, performed in many centers, while LPD is limited to few centers. RCTs and registry studies

Published
2017

49. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, Besselink, MG, de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, and Besselink, MG

Published
2017

50. Worldwide survey on current use, value and safe implementation of minimally invasive pancreatic resection

Author

van Hilst, J., primary, de Rooij, T., additional, Abu Hilal, M., additional, Asbun, H., additional, Barkun, J., additional, Boggi, U., additional, Busch, O., additional, Conlon, K., additional, Dijkgraaf, M., additional, Han, H., additional, Hansen, P., additional, Kendrick, M., additional, Montagnini, A., additional, Palanivelu, C., additional, Rosok, B., additional, Shrikhande, S., additional, Wakabayashi, G., additional, Zeh, H., additional, Vollmer, C., additional, Kooby, D., additional, and Besselink, M., additional

Published
2017
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