1. Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection
- Author
-
Ewa D. Micewicz, Alina Micewicz, Piotr Ruchala, Samuel W. French, and Ronik Khachatoorian
- Subjects
Cell Survival ,Clinical Biochemistry ,Drug Evaluation, Preclinical ,Pharmaceutical Science ,01 natural sciences ,Biochemistry ,Antiviral Agents ,Zika virus ,Small Molecule Libraries ,chemistry.chemical_compound ,Structure-Activity Relationship ,Drug Discovery ,Ic50 values ,ZikV Infection ,Humans ,Urea ,Molecular Biology ,Virus quantification ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Zika Virus Infection ,Organic Chemistry ,Zika Virus ,biology.organism_classification ,Virology ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,A549 Cells ,Molecular Medicine - Abstract
Zika virus (ZIKV) has become a public health concern worldwide due to its association with congenital abnormalities and neurological diseases. To date, no effective vaccines or antiviral drugs have been approved for the treatment of ZIKV infection, and new inexpensive therapeutic options are urgently needed. In this study, we have used an in vitro plaque assay to assess an antiviral activity of the second generation of anti-ZIKV compounds, based on 1,3-disubstituted (thio)urea scaffold. Several compounds in the library were found to possess excellent activity against Zika virus with IC50 values
- Published
- 2019