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Identification of novel small-molecule inhibitors of Zika virus infection
- Source :
- Bioorganicmedicinal chemistry letters. 28(3)
- Publication Year :
- 2017
-
Abstract
- The recent re-emergence of Zika virus (ZIKV), a member of the Flaviviridae family, has become a global emergency and a serious public health threat worldwide. ZIKV infection causes severe neuroimmunopathology and is particularly harmful to the developing fetuses of infected pregnant women causing various developmental abnormalities. Currently, there are no effective methods of preventing or treating ZIKV infection, and new treatment options are urgently needed. Therefore, we have used an in vitro plaque assay to screen a limited proprietary library of small organic compounds and identified highly bioactive leads, with the most active analogs showing activity in low picomolar range. Identified “hits” possess certain common structural features that can be used in the design of the next generation(s) of ZIKV inhibitors. Collectively, our findings suggest that identified compounds represent excellent template(s) for the development of inexpensive and orally available anti-Zika drugs.
- Subjects :
- 0301 basic medicine
Cell Survival
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Antiviral Agents
Zika virus
Small Molecule Libraries
03 medical and health sciences
Flaviviridae
Structure-Activity Relationship
Drug Discovery
ZikV Infection
Humans
Molecular Biology
Virus quantification
biology
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Zika Virus Infection
Organic Chemistry
Treatment options
Zika Virus
biology.organism_classification
Virology
Small molecule
030104 developmental biology
A549 Cells
Molecular Medicine
Identification (biology)
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....fc34058639c0b51440c1586fb4eb3d1e