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1. VersKiK: Evaluation der medizinischen Versorgung bei Personen nach einer Krebserkrankung im Kindes- oder Jugendalter mit GKV-Abrechnungsdaten

Author

Trocchi, P, Merzenich, H, Ronckers, C, Spix, C, Ihle, P, Küpper-Nybelen, J, Lüpkes, C, Horenkamp-Sonntag, D, Dröge, P, Ruhnke, T, Baust, K, Calaminus, G, Langer, T, Aleshchenko, E, Swart, E, Trocchi, P, Merzenich, H, Ronckers, C, Spix, C, Ihle, P, Küpper-Nybelen, J, Lüpkes, C, Horenkamp-Sonntag, D, Dröge, P, Ruhnke, T, Baust, K, Calaminus, G, Langer, T, Aleshchenko, E, and Swart, E

Published
2024

3. Prevalence, risk factors and optimal way to determine overweight, obesity and morbid obesity, in the first Dutch cohort of 2,338 long-term survivors of childhood cancer: a DCCSS-LATER study

Author

Pluimakers, V G, primary, van Atteveld, J E, additional, de Winter, D T C, additional, Bolier, M, additional, Fiocco, M, additional, Nievelstein, R A J, additional, Janssens, G O R, additional, Bresters, D, additional, van der Heiden-van der Loo, M, additional, de Vries, A C H, additional, Louwerens, M, additional, van der Pal, H J, additional, Pluijm, S M F, additional, Ronckers, C M, additional, Versluijs, A B, additional, Kremer, L C M, additional, Loonen, J J, additional, van Dulmen-den Broeder, E, additional, Tissing, W J E, additional, van Santen, H M, additional, van den Heuvel-Eibrink, M M, additional, and Neggers, S J C M M, additional

Published
2023
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4. Psychosocial functioning of parents of Dutch long-term survivors of childhood cancer

Author

Gorp, M. van, Joosten, M.M.H., Maas, A., Drenth, B.L., Aa-van Delden, A. van der, Kremer, L.C.M., Dulmen-den Broeder, E. van, Tissing, W.J.E., Loonen, J.J., Pal, H.J.H. van der, Vries, A.C.H. de, Heuvel-Eibrink, M.M. van den, Ronckers, C., Bresters, D., Louwerens, M., Neggers, S.J.C.C.M., Heiden-van der Loo, M. van der, Maurice-Stam, H., Grootenhuis, M.A., Dutch LATER Study Grp, Pediatrics, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Paediatric Oncology, Paediatric Pulmonology, CCA - Cancer Treatment and Quality of Life, ARD - Amsterdam Reproduction and Development, Child and Adolescent Psychiatry & Psychosocial Care, CCA - Cancer Treatment and quality of life, and Amsterdam Reproduction & Development (AR&D)

Subjects
parents, Experimental and Cognitive Psychology, survivors of childhood cancer, pediatric oncology, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], health-related quality of life, Psychiatry and Mental health, All institutes and research themes of the Radboud University Medical Center, Oncology, SDG 3 - Good Health and Well-being, psychosocial outcomes, illness cognitions, post-traumatic growth, psycho-oncology, post-traumatic stress
Abstract

Contains fulltext : 291391.pdf (Publisher’s version ) (Open Access) OBJECTIVE: To describe health-related quality of life (HRQoL), post-traumatic stress and post-traumatic growth of parents of long-term survivors of childhood cancer (CCS) and study associated factors. METHODS: Parents of survivors of the Dutch Childhood Cancer Survivor Study LATER cohort below 30 years and diagnosed 1986-2001 were invited to complete the TNO-AZL Questionnaire for Adult's HRQoL (e.g., sleep and aggressive emotions), Self-Rating Scale for Post-traumatic Stress Disorder, Post-traumatic Growth Inventory, and Illness Cognition Questionnaire. HRQoL domain scores were compared to references using Mann-Whitney U tests. Correlations between post-traumatic stress, growth and HRQoL were evaluated. Medical characteristics of their child and illness cognitions were studied as associated factors of HRQOL, post-traumatic stress and growth. p

Published
2023

5. The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors

Author

Kooijmans, E.C.M., Pal, H.J.H. van der, Pluijm, S.M.F., Loo, M.V.V. van der van der, Kremer, L.C.M., Bresters, D., Broeder, E.V. den, Heuvel-Eibrink, M.M. van den, Loonen, J.J., Louwerens, M., Neggers, S.J.C., Ronckers, C., Tissing, W.J.E., Vries, A.C.H. de, Kaspers, G.J.L., Veening, M.A., Bokenkamp, A., Dutch LATER Study Grp, Pediatrics, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), Internal Medicine, Paediatric Oncology, CCA - Cancer Treatment and Quality of Life, Paediatrics, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Adult, childhood cancer survivor, Kidney, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Carboplatin, Cohort Studies, All institutes and research themes of the Radboud University Medical Center, Cancer Survivors, SDG 3 - Good Health and Well-being, Risk Factors, Neoplasms, Albumins, Humans, Albuminuria, late effects, Ifosfamide, Prospective Studies, Renal Insufficiency, Chronic, Child, Cyclophosphamide, nephrotoxicity, Cross-Sectional Studies, glomerular toxicity, Nephrology, Creatinine, Cisplatin, Glomerular Filtration Rate
Abstract

This investigation aimed to evaluate glomerular dysfunction among childhood cancer survivors in comparison with matched controls from the general population. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis, a nationwide cross-sectional cohort study, 1024 survivors five or more years after diagnosis, aged 18 or more years at study, treated between 1963-2001 with nephrectomy, abdominal radiotherapy, total body irradiation, cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide or hematopoietic stem cell transplantation participated. In addition, 500 age- and sex-matched controls from Lifelines, a prospective population-based cohort study in the Netherlands, participated. At a median age of 32.0 years (interquartile range 26.6-37.4), the glomerular filtration rate was under 60 ml/min/1.73m2 in 3.7% of survivors and in none of the controls. Ten survivors had kidney failure. Chronic kidney disease according to age-thresholds (glomerular filtration rate respectively under 75 for age under 40, under 60 for ages 40-65, and under 40 for age over 65) was 6.6% in survivors vs. 0.2% in controls. Albuminuria (albumin-to-creatinine ratio over3 mg/mmol) was found in 16.2% of survivors and 1.2% of controls. Risk factors for chronic kidney disease, based on multivariable analyses, were nephrectomy (odds ratio 3.7 (95% Confidence interval 2.1-6.4)), abdominal radiotherapy (1.8 (1.1-2.9)), ifosfamide (2.9 (1.9-4.4)) and cisplatin over 500 mg/m2 (7.2 (3.4-15.2)). For albuminuria, risk factors were total body irradiation (2.3 (1.2-4.4)), abdominal radiotherapy over 30 Gy (2.6 (1.4- 5.0)) and ifosfamide (1.6 (1.0-2.4)). Hypertension and follow-up 30 or more years increased the risk for glomerular dysfunction. Thus, lifetime monitoring of glomerular function in survivors exposed to these identified high risk factors is warranted.

Published
2022

6. Psychosocial outcomes in long-term Dutch adult survivors of childhood cancer: The DCCSS-LATER 2 psycho-oncology study.

Author

Maas, A, Maurice-Stam, H., Kremer, L.C.M., Aa-van Delden, A. van der, Dulmen-den Broeder, E. van, Tissing, W.J.E., Loonen, J.J., Pal, H.J.H. van der, Vries, A.C.H. de, Heuvel-Eibrink, M.M. van den, Ronckers, C., Neggers, S., Bresters, D., Louwerens, M., Heiden-van der Loo, M. van der, Gorp, M. van, Grootenhuis, M., Maas, A, Maurice-Stam, H., Kremer, L.C.M., Aa-van Delden, A. van der, Dulmen-den Broeder, E. van, Tissing, W.J.E., Loonen, J.J., Pal, H.J.H. van der, Vries, A.C.H. de, Heuvel-Eibrink, M.M. van den, Ronckers, C., Neggers, S., Bresters, D., Louwerens, M., Heiden-van der Loo, M. van der, Gorp, M. van, and Grootenhuis, M.

Abstract

Contains fulltext : 295976.pdf (Publisher’s version ) (Open Access), BACKGROUND: This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population-based references and identifies sociodemographic and medical risk factors. METHODS: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963-2001) part 2 (attained age ≥18 years, diagnosed <18 years, ≥5 years since diagnosis) completed the Rosenberg Self-Esteem Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Self-Rating Scale for Post-Traumatic Stress Disorder, and the Short Form-36 (Health Related Quality of Life). CCS' scores were compared with references using analysis of variances and logistic regression analysis, controlling for age and sex (p < .05). Risk factors for worse psychosocial outcomes were assessed with regression analyses (p < .05). RESULTS: CCS, N = 1797, mean age 35.4 years, 49.0% female, all ≥15 years since diagnosis, participated. Three percent reported posttraumatic stress disorder because of childhood cancer and 36.6% experienced clinical distress. CCS did not differ from references on self-esteem and anxiety but were less depressed (d = -.25), and scored poorer on all health-related quality of life scales, except for bodily pain (.01 ≤ d ≥ -.36). Female sex, lower educational attainment, not being in a relationship, and being unemployed were negatively associated with almost all psychosocial outcomes. Except for a central nervous system tumor diagnosis, few medical characteristics were associated with psychosocial outcomes. CONCLUSION: CCS appear resilient regarding mental health but have slightly poorer health-related quality of life than references. Sociodemographic characteristics and central nervous system tumors were related to most psychosocial outcomes, but no clear pattern was observed for other medical factors. Future studies should address additional factors in explaining CCS' psychosocial functioning, such as coping, social support, and ph

Published
2023

7. Chronic fatigue in childhood cancer survivors is associated with lifestyle and psychosocial factors; a DCCSS LATER study

Author

Penson, A., Walraven, I., Bronkhorst, E., Grootenhuis, M. A., Maurice-Stam, H., de Beijer, I., van der Heiden-van der Loo, M., Tissing, W. J.E., van der Pal, H. J.H., de Vries, A. C.H., Bresters, D., Ronckers, C. M., van den Heuvel-Eibrink, M. M., Neggers, S., Versluys, B. A.B., Louwerens, M., Pluijm, S. M.F., Blijlevens, N., van Dulmen-den Broeder, E., Kremer, L. C.M., Knoop, H., Loonen, J., Penson, A., Walraven, I., Bronkhorst, E., Grootenhuis, M. A., Maurice-Stam, H., de Beijer, I., van der Heiden-van der Loo, M., Tissing, W. J.E., van der Pal, H. J.H., de Vries, A. C.H., Bresters, D., Ronckers, C. M., van den Heuvel-Eibrink, M. M., Neggers, S., Versluys, B. A.B., Louwerens, M., Pluijm, S. M.F., Blijlevens, N., van Dulmen-den Broeder, E., Kremer, L. C.M., Knoop, H., and Loonen, J.

Abstract

Background: The purpose of this study was to determine factors associated with chronic fatigue (CF) in childhood cancer survivors (CCS). Patients and methods: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS (≥5 years after diagnosis) and siblings as controls. Fatigue severity was assessed with the ‘fatigue severity subscale’ of the Checklist Individual Strength (‘CIS-fatigue’). CF was defined as scoring ≥35 on the ‘CIS-fatigue’ and having fatigue symptoms for ≥6 months. Twenty-four parameters were assessed, categorized into assumed fatigue triggering, maintaining and moderating factors. Multivariable logistic regression analyses were carried out to investigate the association of these factors with CF. Results: A total of 1927 CCS participated in the study (40.7% of invited cohort), of whom 23.6% reported CF (compared with 15.6% in sibling controls, P < 0.001). The following factors were associated with CF: obesity [versus healthy weight, odds ratio (OR) 1.93; 95% confidence interval (CI) 1.30-2.87], moderate physical inactivity (versus physical active, OR 2.36; 95% CI 1.67-3.34), poor sleep (yes versus no, OR 2.03; 95% CI 1.54-2.68), (sub)clinical anxiety (yes versus no, OR 1.55; 95% CI 1.10-2.19), (sub)clinical depression (yes versus no, OR 2.07; 95% CI 1.20-3.59), pain (continuous, OR 1.49; 95% CI 1.33-1.66), self-esteem (continuous, OR 0.95; 95% CI 0.92-0.98), helplessness (continuous, OR 1.13; 95% CI 1.08-1.19), social functioning (continuous, OR 0.98; 95% CI 0.97-0.99) and female sex (versus male sex, OR 1.79; 95% CI 1.36-2.37). Conclusion: CF is a prevalent symptom in CCS that is associated with several assumed maintaining factors, with lifestyle and psychosocial factors being the most prominent. These are modifiable factors and may therefore be beneficial to prevent or reduce CF in CCS.

Published
2023

8. Prevalence, risk factors and optimal way to determine overweight, obesity and morbid obesity, in the first Dutch cohort of 2,338 long-term survivors of childhood cancer: a DCCSS-LATER study

Author

Unit Opleiding Aios, Orthopaedie Onderzoek, MS Radiologie, Child Health, MS Radiotherapie, Cancer, SCT patientenzorg, PMC Medisch specialisten, PMC Research, Klinische Fysica RT, Haematologie patientenzorg, Zorg en O&O, Endocrinologie patientenzorg, Brain, Speerpunt, In Vivo NMR ISI, Pluimakers, V G, van Atteveld, J E, de Winter, D T C, Bolier, M, Fiocco, M, Nievelstein, R A J, Janssens, G O R, Bresters, D, van der Heiden-van der Loo, M, de Vries, A C H, Louwerens, M, van der Pal, H J, Pluijm, S M F, Ronckers, C M, Versluijs, A B, Kremer, L C M, Loonen, J J, van Dulmen-den Broeder, E, Tissing, W J E, van Santen, H M, van den Heuvel-Eibrink, M M, Neggers, S J C M M, Unit Opleiding Aios, Orthopaedie Onderzoek, MS Radiologie, Child Health, MS Radiotherapie, Cancer, SCT patientenzorg, PMC Medisch specialisten, PMC Research, Klinische Fysica RT, Haematologie patientenzorg, Zorg en O&O, Endocrinologie patientenzorg, Brain, Speerpunt, In Vivo NMR ISI, Pluimakers, V G, van Atteveld, J E, de Winter, D T C, Bolier, M, Fiocco, M, Nievelstein, R A J, Janssens, G O R, Bresters, D, van der Heiden-van der Loo, M, de Vries, A C H, Louwerens, M, van der Pal, H J, Pluijm, S M F, Ronckers, C M, Versluijs, A B, Kremer, L C M, Loonen, J J, van Dulmen-den Broeder, E, Tissing, W J E, van Santen, H M, van den Heuvel-Eibrink, M M, and Neggers, S J C M M

Published
2023

9. Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

Author

Maas, A., Maurice-Stam, H., Aa-van Delden, A.M. van der, Dalen, E.C. van, Dulmen-den Broeder, E. van, Tissing, W.J.E., Loonen, J.J., Pal, H.J.H. van der, Vries, A.C.H. de, Heuvel-Eibrink, M.M. van den, Janssens, G.O., Ronckers, C., Neggers, S., Bresters, D., Louwerens, M., Versluys, B.A.B., Heiden-van der Loo, M. van der, Kremer, L.C.M., Gorp, M. van, Grootenhuis, M.A., and Dutch LATER Study Group

Subjects
Quality of life, Impact of cancer, Long-term survivorship, Childhood cancer survivors, Psychosocial
Abstract

Purpose: Numerous studies investigated generic psychosocial outcomes in survivors of childhood cancer (CCS). The present study aimed to describe survivor-specific psychosocial consequences in CCS, and to identify socio-demographic and medical associated factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963-2001) part 2 (age >= 18 years, diagnosed < 18 years, >= 5 years since diagnosis) completed the Benefit & Burden Scale (BBSC) and the Impact of Cancer-Childhood Cancer (IOC-CS). Items were scored on a 5-point Likert scale (range 1-5). We examined outcomes with descriptive statistics, and socio-demographic and medical associated factors with regression analyses, corrected for multiple testing (p < 0.004). Results: CCS, N = 1713, age mean (M) 36 years, 49% female, >= 15 years since diagnosis, participated. On average, CCS reported 'somewhat' Benefit (M = 2.9), and 'not at all' to 'a little' Burden (M = 1.5) of childhood cancer. Average scores on IOC-CS' positive impact scales ranged from 2.5 (Personal Growth) to 4.1 (Socializing), and on the negative impact scales from 1.4 (Financial Problems) to 2.4 (Thinking/Memory). Apart from cognitive problems, CCS reported challenges as worries about relationship status, fertility, and how cancer had affected siblings. Female sex was associated with more Personal Growth, and more negative impact. CCS more highly educated, partnered, and employed had higher positive and lower negative impact. CCS older at diagnosis reported more positive impact. CNS tumor survivors and those who had head/cranium radiotherapy had higher negative impact. CNS tumor survivors reported less positive impact. Conclusion and implications: The majority of CCS reported positive impact of cancer while most CCS reported little negative impact. While this may indicate resiliency in most CCS, health care providers should be aware that they can also experience survivor-specific challenges that warrant monitoring/screening, information provision and psychosocial support.

Published
2023

10. Zweitmeinungsbedarfe in der Onkologie: Eine qualitative Studie mit Brustkrebspatient:innen

Author

Bruch, D, May, S, Ernstmann, N, Holmberg, C, Ronckers, C, and Neugebauer, E

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund und Forschungsstand: In Deutschland besteht kein einheitliches Verfahren für Brustkrebspatient:innen eine Zweimeinung (ZM) zu erhalten. Bisherige Forschungsergebnisse zeigen, dass Patient:innen vielfach nicht von der Möglichkeit einer ZM wissen, aber Interesse zur Inanspruchnahme [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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12. Acute Ovarian Failure and Premature Ovarian Insufficiency in Childhood Cancer Survivors Who Received Radiotherapy: A PENTEC Report

Author

Hill-Kayser, C.E., primary, Yorke, E.D., additional, Gracia, C.R., additional, Keene, K.S., additional, Ronckers, C., additional, van Dulmen-den Broe, E., additional, Kremer, L., additional, Ginsberg, J., additional, Metzger, M.L., additional, Li, Z., additional, Jackson, A., additional, Constine, L.S., additional, and Hua, C.H., additional

Published
2022
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13. Risk of Cerebrovascular Events among Childhood and Adolescent Patients Receiving Cranial Radiotherapy: A PENTEC Normal Tissue Outcomes Comprehensive Review

Author

Waxer, J.F., primary, Wong, K., additional, Modiri, A., additional, Charpentier, A.M., additional, Moiseenko, V., additional, Ronckers, C., additional, Taddei, P.J., additional, Constine, L.S., additional, Sprow, G., additional, Tamrazi, B., additional, MacDonald, S., additional, and Olch, A.J., additional

Published
2022
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14. Original Research Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study

Author

Kooijmans, E.C.M., Pal, H.J.H. van der, Pluijm, S.M.F., Bresters, D., Dulmen-den Broeder, E. van, Heiden-van der Loo, M. van der, Heuvel-Eibrink, M.M. van den, Kremer, L.C.M., Loonen, J.J., Louwerens, M., Neggers, S.J.C., Pilon, M., Ronckers, C., Tissing, W.J.E., Vries, A.C.H. de, Kaspers, G.J.L., Bokenkamp, A., Veening, M.A., and Dutch LATER Study Grp

Subjects
Late effects, Hypertension, Ambulatory blood pressure monitoring, Nephrotoxicity, Childhood cancer survivor
Abstract

Purpose: To evaluate the prevalence of and risk factors for hypertension in child-hood cancer survivors (CCSs) who were treated with potentially nephrotoxic therapies. Methods: In the Dutch Childhood Cancer Survivor Study LATER cohort part 2 renal study, 1024 CCS >= 5 years after diagnosis, aged >= 18 years at study participation, treated between 1963 and 2001 with nephrectomy, abdominal radiotherapy, total body irradiation (TBI), cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide (>= 1 g/m(2) per single dose or >= 10 g/m(2) total) or haematopoietic stem cell transplantation participated and 500 controls from Lifelines. Hypertension was defined as blood pressure (BP) (mmHg) systolic >= 140 and/or diastolic >= 90 or receiving medication for diagnosed hypertension. At the study visit, the CKD-EPI 2012 equation including creatinine and cystatin C was used to estimate the glomerular filtration rate (GFR). Multivariable regression analyses were used. For ambulatory BP monitoring (ABPM), hypertension was defined as BP daytime: systolic >= 135 and/or diastolic >= 85, night time: systolic >= 120 and/or diastolic >= 70, 24-h: systolic >= 130 and/or diastolic >= 80. Outcomes were masked hypertension (MH), white coat hypertension and abnormal nocturnal dipping (aND). Results: Median age at cancer diagnosis was 4.7 years (interquartile range, IQR 2.4-9.2), at study 32.5 years (IQR 27.7-38.0) and follow-up 25.5 years (IQR 21.4-30.3). The prevalence of hypertension was comparable in CCS (16.3%) and controls (18.2%). In 12% of CCS and 17.8% of controls, hypertension was undiagnosed. A decreased GFR (< 60 ml/min/1.73 m(2)) was associated with hypertension in CCS (OR 3.4, 95% CI 1.4-8.5). Risk factors were abdominal radiotherapy >= 20 Gy and TBI. The ABPM-pilot study (n Z 77) showed 7.8% MH, 2.6% Conclusion: The prevalence of hypertension was comparable among CCS who were treated with potentially nephrotoxic therapies compared to controls, some of which were undiagnosed. Risk factors were abdominal radiotherapy >= 20 Gy and TBI. Hypertension and decreased GFR were associated with CCS. ABPM identified MH and a ND. (C) 2022 The Author(s). Published by Elsevier Ltd.

Published
2022

15. Long-Term Tubular Dysfunction in Childhood Cancer Survivors; DCCSS-LATER 2 Renal Study

Author

Kooijmans, E.C.M., Pal, H.J.H. van der, Pluijm, S.M.F., Heiden-van der Loo, M. van der, Kremer, L.C.M., Bresters, D., Dulmen-den Broeder, E. van, Heuvel-Eibrink, M.M. van den, Loonen, J.J., Louwerens, M., Neggers, S.J.C., Ronckers, C., Tissing, W.J.E., Vries, A.C.H. de, Kaspers, G.J.L., Bokenkamp, A., Veening, M.A., Dutch LATER Study Group, Pediatrics, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Paediatric Oncology, CCA - Cancer Treatment and Quality of Life, Paediatrics, and Internal Medicine

Subjects
Cancer Research, childhood cancer survivor, ALPHA-1-MICROGLOBULIN, OUTCOMES, nephrotoxicity, tubular dysfunction, CHILDREN, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], CISPLATIN, All institutes and research themes of the Radboud University Medical Center, Oncology, SDG 3 - Good Health and Well-being, RISK-FACTORS, SARCOMA PATIENTS, HEALTH, HYPOMAGNESEMIA, IFOSFAMIDE-INDUCED NEPHROTOXICITY, ACUTE LYMPHOBLASTIC-LEUKEMIA
Abstract

Simple Summary We studied survivors of childhood cancer who received cancer treatment that might affect the kidneys and compared them to controls from the general population. We investigated if there was a difference in the occurrence of tubular dysfunction. The tubules are the part of the kidney responsible for reabsorption of needed substances to the blood and the removal of wastes. After around 25 years since their cancer diagnosis, we found that in general there were no differences between survivors and controls, but survivors more often had losses of small proteins in the urine. Yet, some survivors of childhood cancer were found to have an increased risk of tubular dysfunction. Namely, survivors treated with the chemotherapeutic agents ifosfamide, cisplatin or carboplatin. Therefore, these patients should be monitored during their follow-up. The aim of this nationwide cross-sectional cohort study was to determine the prevalence of and risk factors for tubular dysfunction in childhood cancer survivors (CCS). In the DCCSS-LATER 2 Renal study, 1024 CCS (>= 5 years after diagnosis), aged >= 18 years at study, treated between 1963 and 2001 with potentially nephrotoxic therapy (i.e., nephrectomy, abdominal radiotherapy, total body irradiation, cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide, or hematopoietic stem cell transplantation) participated, and 500 age- and sex-matched participants from Lifelines acted as controls. Tubular electrolyte loss was defined as low serum levels (magnesium < 0.7 mmol/L, phosphate < 0.7 mmol/L and potassium < 3.6 mmol/L) with increased renal excretion or supplementation. A alpha 1-microglobulin:creatinine ratio > 1.7 mg/mmol was considered as low-molecular weight proteinuria (LMWP). Multivariable risk analyses were performed. After median 25.5 years follow-up, overall prevalence of electrolyte losses in CCS (magnesium 5.6%, potassium 4.5%, phosphate 5.5%) was not higher compared to controls. LMWP was more prevalent (CCS 20.1% versus controls 0.4%). LMWP and magnesium loss were associated with glomerular dysfunction. Ifosfamide was associated with potassium loss, phosphate loss (with cumulative dose > 42 g/m(2)) and LMWP. Cisplatin was associated with magnesium loss and a cumulative dose > 500 mg/m(2) with potassium and phosphate loss. Carboplatin cumulative dose > 2800 mg/m(2) was associated with potassium loss. In conclusion, long-term tubular dysfunction is infrequent. Yet, ifosfamide, cisplatin and carboplatin are risk factors.

Published
2022

16. 072 Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function

Author

van der Kooi, A.L.L.F., primary, van Dijk, M., additional, Broer, L., additional, van den Berg, M., additional, Laven, J., additional, van Leeuwen, F., additional, Ronckers, C., additional, van der Heiden-van der Loo, M., additional, Hudson, M., additional, Byrne, J., additional, Pluijm, S., additional, Spix, C., additional, Kaatsch, P., additional, Kremer, L., additional, Yasui, Y., additional, Brooke, J., additional, Uitterlinden, A., additional, van den Heuvel-Eibrink, M., additional, and van Dulmen-den Broeder, E., additional

Published
2022
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18. The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study

Author

Penson, A., Walraven, I., Bronkhorst, E.M., Maurice-Stam, H., Grootenhuis, M.A., Heiden-van der Loo, M., Tissing, W.J.E., Pal, H.J. van der, Vries, A.C.M. de, Bresters, D., Ronckers, C., Heuvel, Marry M., Neggers, S., Versluys, B.A., Louwerens, M., Pluijm, S.M.F., Kremer, L.C., Blijlevens, N.M., Dulmen-den Broeder, E. van, Knoop, H., Loonen, J.J., Penson, A., Walraven, I., Bronkhorst, E.M., Maurice-Stam, H., Grootenhuis, M.A., Heiden-van der Loo, M., Tissing, W.J.E., Pal, H.J. van der, Vries, A.C.M. de, Bresters, D., Ronckers, C., Heuvel, Marry M., Neggers, S., Versluys, B.A., Louwerens, M., Pluijm, S.M.F., Kremer, L.C., Blijlevens, N.M., Dulmen-den Broeder, E. van, Knoop, H., and Loonen, J.J.

Abstract

Contains fulltext : 251637.pdf (Publisher’s version ) (Open Access), BACKGROUND: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. METHODS: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult's Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples t-tests and ANCOVA to adjust for age and sex. The association between CF and impaired HRQOL (scoring ≥ 2 SD below the population norm) was investigated using logistic regression analyses, adjusting for confounders. RESULTS: A total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3-3.4; sexuality domain) to 30.4 (95% CI 16.4-56.2; vitality domain). CONCLUSIONS: CF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.

Published
2022

19. Female reproductive function after treatment of childhood acute lymphoblastic leukemia

Author

Roshandel, R., Dijk, M. van, Overbeek, A., Kaspers, G., Lambalk, C., Beerendonk, C.C., Bresters, D., Heiden-van der Loo, M., Heuvel-Eibrink, M. van den, Kremer, L., Loonen, J.J., Pal, H. Van der, Ronckers, C., Tissing, W., Versluys, B., Leeuwen, F van, Berg, M. van den, Dulmen-den Broeder, E. van, Roshandel, R., Dijk, M. van, Overbeek, A., Kaspers, G., Lambalk, C., Beerendonk, C.C., Bresters, D., Heiden-van der Loo, M., Heuvel-Eibrink, M. van den, Kremer, L., Loonen, J.J., Pal, H. Van der, Ronckers, C., Tissing, W., Versluys, B., Leeuwen, F van, Berg, M. van den, and Dulmen-den Broeder, E. van

Abstract

Contains fulltext : 244604.pdf (Publisher’s version ) (Closed access), BACKGROUND: The aim was to evaluate self-reported reproductive characteristics and markers of ovarian function in a nationwide cohort of female survivors of childhood acute lymphoblastic leukemia (ALL), because prior investigations have produced conflicting data. PROCEDURE: Self-reported reproductive characteristics were assessed by questionnaire among 357 adult 5-year survivors, treated between 1964 and 2002, and 836 controls. Ovarian function was assessed by serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and inhibin B and by antral follicle count (AFC). Differences between controls and (subgroups of) survivors (total group, chemotherapy [CT]-only group, CT and radiotherapy [RT] group) were analyzed. RESULTS: Survivors treated with CT only do not differ from controls regarding timing of menarche, virginity status, desire for children, or pregnancy rates. Compared to controls, the CT+RT group was at significantly increased risk of a younger age at menarche (P < .01), virginity, an absent desire for children, and lower pregnancy rates (odds ratio [OR] [95% CI]: 0.3 [CI 0.1-0.6], 0.5 [0.3-0.9], and 0.4 [0.2-0.9], respectively). Survivors in the CT-only group were significantly younger at the birth of their first child. Pregnancy outcomes were not significantly different between any (sub)groups. Survivors treated with total body irradiation (TBI) or hematopoietic stem cell transplantation (HSCT) are at increased risk of abnormal markers of ovarian function. CONCLUSION: Reproductive function of ALL survivors treated with CT only does not differ from controls. However, survivors additionally treated with RT seem to be at an increased risk of certain adverse reproductive outcomes. Providing personalized counseling about (future) reproductive health risks in this group is imperative.

Published
2021

20. Metabolic syndrome parameters, determinants, and biomarkers in adult survivors of childhood cancer: Protocol for the Dutch childhood cancer survivor study on metabolic syndrome (Dutch LATER METS)

Author

Pluimakers, V. (Vincent), Fiocco, M. (Marta), van Atteveld, J. (Jenneke), Hobbelink, M. (Monique), Bresters, D. (Dorine), Dulmen-den Broeder, E. (Eline) van, Heiden-Van der Loo, M. (Margriet) van der, Janssens, G.O. (Geert), Kremer, L.C.M. (Leontien), Loonen, J.J. (Jacqueline), Louwerens, M. (Marlous), van der Pal, H. (Helena), Ronckers, C. (Cécile), Van Santen, H.M. (Hanneke M.), Versluys, B. (Birgitta), Vries, A.C.H. (Andrica) de, Heuvel-Eibrink, M.M. (Marry) van den, Neggers, S. (Sebastian), Pluimakers, V. (Vincent), Fiocco, M. (Marta), van Atteveld, J. (Jenneke), Hobbelink, M. (Monique), Bresters, D. (Dorine), Dulmen-den Broeder, E. (Eline) van, Heiden-Van der Loo, M. (Margriet) van der, Janssens, G.O. (Geert), Kremer, L.C.M. (Leontien), Loonen, J.J. (Jacqueline), Louwerens, M. (Marlous), van der Pal, H. (Helena), Ronckers, C. (Cécile), Van Santen, H.M. (Hanneke M.), Versluys, B. (Birgitta), Vries, A.C.H. (Andrica) de, Heuvel-Eibrink, M.M. (Marry) van den, and Neggers, S. (Sebastian)

Abstract

Background: Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia, and hypertension. These risk factors cluster together as metabolic syndrome and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis, and preventive strategies is of importance to prevent cardio- and cerebrovascular complications and improve quality of life. Currently, no national cohort studies on the prevalence and determinants of metabolic syndrome in childhood cancer survivors, including biomarkers and genetic predisposition, are available. Objective: The objectives of the Dutch LATER METS study are to assess 1) the prevalence and risk factors of metabolic syndrome and its separate components, and 2) the potential diagnostic and predictive value of additional biomarkers for surveillance of metabolic syndrome in the national cohort of adult long-term survivors of childhood cancer. Methods

Published
2021
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21. Metabolic syndrome parameters, determinants, and biomarkers in adult survivors of childhood cancer: Protocol for the Dutch childhood cancer survivor study on metabolic syndrome (Dutch LATER METS)

Author

Pluimakers, V, Fiocco, M, van Atteveld, J, Hobbelink, M, Bresters, D, van Dulmen-Den Broeder, E, van der Heiden-van der Loo, M, Janssens, GO, Kremer, L, Loonen, J, Louwerens, M, van der Pal, H, Ronckers, C, van Santen, H, Versluys, B, de Vries, A.C.H., van den Heuvel-Eibrink, M, Neggers, S.J.C.M.M., Pluimakers, V, Fiocco, M, van Atteveld, J, Hobbelink, M, Bresters, D, van Dulmen-Den Broeder, E, van der Heiden-van der Loo, M, Janssens, GO, Kremer, L, Loonen, J, Louwerens, M, van der Pal, H, Ronckers, C, van Santen, H, Versluys, B, de Vries, A.C.H., van den Heuvel-Eibrink, M, and Neggers, S.J.C.M.M.

Abstract

Background: Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia, and hypertension. These risk factors cluster together as metabolic syndrome and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis, and preventive strategies is of importance to prevent cardio- and cerebrovascular complications and improve quality of life. Currently, no national cohort studies on the prevalence and determinants of metabolic syndrome in childhood cancer survivors, including biomarkers and genetic predisposition, are available. Objective: The objectives of the Dutch LATER METS study are to assess 1) the prevalence and risk factors of metabolic syndrome and its separate components, and 2) the potential diagnostic and predictive value of additional biomarkers for surveillance of metabolic syndrome in the national cohort of adult long-term survivors of childhood cancer. Methods: This is a cross-sectional study based on recruitment of all survivors treated in the Netherlands between 1963 and 2002. Metabolic syndrome will be classified according to the definitions of the third Adult Treatment Panel Report of the National Cholesterol Education Program as well as the Joint Interim Statement and compared to reference data. Dual-energy x-ray absorptiometry scans were performed to assess body composition in more detail. The effect of patient characteristics, previous treatment, and genetic variation on the risk of metabolic syndrome will be assessed. The diagnostic and predictive value of novel biomarkers will be tested. Results: Patient accrual started in 2016 and lasted until April 2020. A total of 2380 survivors from 7 pediatric oncology hospitals have participated. From July 2020, biomarker testing, single nucleotide polymorphism analysis, and data analysis will be performed. Conclusions: The Dutch LATER METS study will provide knowledge on clinic

Published
2021

24. 'Nee, nee. Brandenburg ist zu groß für einen Zweitmeiner' – die aktuelle Richtlinie zum Zweitmeinungsverfahren aus Sicht der Fachärzt*innen

Author

May, S, Bruch, D, Alexandrov, A, von Peter, S, Ronckers, C, and Neugebauer, E

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund und Stand (inter)nationaler Forschung: Das Recht auf Zweitmeinung (ZM) ist gesetzlich verankert (§ 27b SGB V) und seit 2018 ist die neue Richtlinie (RL) zur ZM bei planbaren Eingriffen, wie der Hysterektomie, Tonsillotomie und Tonsillektomie in Kraft getreten [ref:1]; ergänzt[zum vollständigen Text gelangen Sie über die oben angegebene URL], 19. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2020
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25. Landelijke richtlijnen voor follow-up van overlevenden van kinderkanker

Author

Kremer, L. C. M., Jaspers, M. W. M., van Leeuwen, F. E., Versluys, A. B., Bresters, D., Bökkerink, J. P. M., Hakvoort-Cammel, F. G. A. J., Postma, A., Schouten-van Meeteren, A. Y. N., van Dulmen-den Broeder, E., van der Pal, H. J. H., Hazelhoff, J., Ronckers, C. M., van Dam, E. W. C. M., Braam, K. I., van der Linden, G. H. M, Blaauwbroek, R., de Ridder-Sluiter, J. G., and van den Bos, C.

Published
2006
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26. Befragung von niedergelassenen Ärzt*innen und Psychotherapeut*innen in Brandenburg zu den Auswirkungen der COVID-19- Pandemie auf die Berufsausübung und das Patient*innenaufkommen in den Praxen (CO-BRA) - ein Kooperationsprojekt der Medizinischen Hochschule Brandenburg und der Kassenärztlichen Vereinigung Brandenburg

Author

May, S, Bruch, D, Alexandrov, A, Voß, K, Konstantinova, Y, Ronckers, C, Neugebauer, E, May, S, Bruch, D, Alexandrov, A, Voß, K, Konstantinova, Y, Ronckers, C, and Neugebauer, E

Published
2020

27. Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer

Author

Kok, Judith L., Teepen, J.C., Pal, Helena J. van der, Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Loonen, J.J., Hoeben, B.A.W., Jongmans, M.C.J., Kremer, L.C., Ronckers, C., Rij, C.M. van, Tersteeg, R.J.H.A., Kok, Judith L., Teepen, J.C., Pal, Helena J. van der, Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Loonen, J.J., Hoeben, B.A.W., Jongmans, M.C.J., Kremer, L.C., Ronckers, C., Rij, C.M. van, and Tersteeg, R.J.H.A.

Abstract

Contains fulltext : 204007.pdf (Publisher’s version ) (Closed access)

Published
2019

29. Hypothyroidism (HT) after Radiotherapy (RT) in Children: Initial Results of Thyroid Gland Dose-Response Relationship from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Initiative

Author

Endocrinologie patientenzorg, Child Health, Vogelius, Ivan, Vargo, John Austin, Ronckers, C. M., Yorke, E.D., Kremer, L.C., Chafe, S.M.J.M.J., van Santen, HM, Bentzen, S.M., Constine, Louis S, Milano, M.T., Endocrinologie patientenzorg, Child Health, Vogelius, Ivan, Vargo, John Austin, Ronckers, C. M., Yorke, E.D., Kremer, L.C., Chafe, S.M.J.M.J., van Santen, HM, Bentzen, S.M., Constine, Louis S, and Milano, M.T.

Published
2019

30. Colorectal Adenomas and Cancers After Childhood Cancer Treatment : A DCOG-LATER Record Linkage Study

Author

Teepen, J C, Kok, Judith L, van Leeuwen, Flora E, Tissing, Wim J E, Dolsma, Wil V, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, A B, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van den Berg, Marleen H, van der Heiden-van der Loo, Margriet, Hauptmann, Michael, Jongmans, M C, Overbeek, L I, van de Vijver, M J, Kremer, L C M, Ronckers, C M, Aleman, B M P, van den Berg, M H, Caron, H N, Daniels, L A, Dolsma, W, van Dulmen-den Broeder, E, Grootenhuis, M A, Haasbeek, C J, den Hartogh, J G, Hauptmann, M, van der Heiden-van der Loo, M, Hollema, N, Janssens, G O, Jaspers, M W M, Kok, J L, van Leeuwen, F E, Loonen, J, Maduro, J H, Neggers, S J C M M, Oldenburger, F, van der Pal, H J, Postma, A, Tersteeg, R J, Zsíros, J, and DCOG-LATER Study Group

Abstract

Background: Although colorectal adenomas serve as prime target for colorectal cancer (CRC) surveillance in other high-risk groups, data on adenoma risk after childhood cancer are lacking. We evaluated the risk of histologically confirmed colorectal adenomas among childhood cancer survivors. A secondary aim was to assess CRC risk. Methods: The DCOG-LATER cohort study includes five-year Dutch childhood cancer survivors and a sibling comparison group (n = 883). Colorectal tumors were identified from the population-based Dutch Pathology Registry (PALGA). We calculated cumulative incidences of adenomas/CRCs for survivors and siblings. For adenomas, multivariable Cox regression models were used to evaluate potential risk factors. All statistical tests were two-sided. Results: Among 5843 five-year survivors (median follow-up = 24.9 years), 78 individuals developed an adenoma. Cumulative incidence by age 45 years was 3.6% (95% confidence interval [CI] = 2.2% to 5.6%) after abdominopelvic radiotherapy (AP-RT; 49 cases) vs 2.0% (95% CI = 1.3% to 2.8%) among survivors without AP-RT (28 cases; Pdifference = .07) and vs 1.0% (95% CI = 0.3% to 2.6%) among siblings (6 cases) (Pdifference = .03). Factors associated with adenoma risk were AP-RT (hazard ratio [HR] = 2.12, 95% CI = 1.24 to 3.60), total body irradiation (TBI; HR = 10.55, 95% CI = 5.20 to 21.42), cisplatin (HR = 2.13; 95% CI = 0.74 to 6.07 for

Published
2018

31. Long-term effects of childhood cancer treatment on hormonal and ultrasound markers of ovarian reserve

Author

Van Den Berg, M. H., Overbeek, A., Lambalk, C. B., Kaspers, G. J.L., Bresters, D., Van Den Heuvel-Eibrink, M. M., Kremer, L. C., Loonen, J. J., Van Der Pal, H. J., Ronckers, C. M., Tissing, W. J.E., Versluys, A. B., Van Der Heiden-Van Der Loo, M., Heijboer, A. C., Hauptmann, M., Twisk, J. W.R., Laven, J. S.E., Beerendonk, C. C.M., Van Leeuwen, F. E., Van Dulmen-Den Broeder, E., Van Den Berg, M. H., Overbeek, A., Lambalk, C. B., Kaspers, G. J.L., Bresters, D., Van Den Heuvel-Eibrink, M. M., Kremer, L. C., Loonen, J. J., Van Der Pal, H. J., Ronckers, C. M., Tissing, W. J.E., Versluys, A. B., Van Der Heiden-Van Der Loo, M., Heijboer, A. C., Hauptmann, M., Twisk, J. W.R., Laven, J. S.E., Beerendonk, C. C.M., Van Leeuwen, F. E., and Van Dulmen-Den Broeder, E.

Published
2018

32. Colorectal Adenomas and Cancers After Childhood Cancer Treatment: A DCOG-LATER Record Linkage Study

Author

Genetica Klinische Genetica, PMC Medisch specialisten, SCT patientenzorg, Child Health, Zorg en O&O, Klinische Fysica RT, Speerpunt, MS Neonatologie, Fysica Radiotherapie Research, Onderzoeksgroep 7, Brain, ZL Cerebrovasculaire Ziekten Medisch, MS Radiotherapie, Cancer, Teepen, J C, Kok, Judith L, van Leeuwen, Flora E, Tissing, Wim J E, Dolsma, Wil V, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, A B, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van den Berg, Marleen H, van der Heiden-van der Loo, Margriet, Hauptmann, Michael, Jongmans, M C, Overbeek, L I, van de Vijver, M J, Kremer, L C M, Ronckers, C M, Aleman, B M P, van den Berg, M H, Caron, H N, Daniels, L A, Dolsma, W, van Dulmen-den Broeder, E, Grootenhuis, M A, Haasbeek, C J, den Hartogh, J G, Hauptmann, M, van der Heiden-van der Loo, M, Hollema, N, Janssens, G O, Jaspers, M W M, Kok, J L, van Leeuwen, F E, Loonen, J, Maduro, J H, Neggers, S J C M M, Oldenburger, F, van der Pal, H J, Postma, A, Tersteeg, R J, Zsíros, J, DCOG-LATER Study Group, Genetica Klinische Genetica, PMC Medisch specialisten, SCT patientenzorg, Child Health, Zorg en O&O, Klinische Fysica RT, Speerpunt, MS Neonatologie, Fysica Radiotherapie Research, Onderzoeksgroep 7, Brain, ZL Cerebrovasculaire Ziekten Medisch, MS Radiotherapie, Cancer, Teepen, J C, Kok, Judith L, van Leeuwen, Flora E, Tissing, Wim J E, Dolsma, Wil V, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, A B, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van den Berg, Marleen H, van der Heiden-van der Loo, Margriet, Hauptmann, Michael, Jongmans, M C, Overbeek, L I, van de Vijver, M J, Kremer, L C M, Ronckers, C M, Aleman, B M P, van den Berg, M H, Caron, H N, Daniels, L A, Dolsma, W, van Dulmen-den Broeder, E, Grootenhuis, M A, Haasbeek, C J, den Hartogh, J G, Hauptmann, M, van der Heiden-van der Loo, M, Hollema, N, Janssens, G O, Jaspers, M W M, Kok, J L, van Leeuwen, F E, Loonen, J, Maduro, J H, Neggers, S J C M M, Oldenburger, F, van der Pal, H J, Postma, A, Tersteeg, R J, Zsíros, J, and DCOG-LATER Study Group

Published
2018

33. Long-term effects of childhood cancer treatment on hormonal and ultrasound markers of ovarian reserve

Author

Child Health, Haematologie patientenzorg, Van Den Berg, M. H., Overbeek, A., Lambalk, C. B., Kaspers, G. J.L., Bresters, D., Van Den Heuvel-Eibrink, M. M., Kremer, L. C., Loonen, J. J., Van Der Pal, H. J., Ronckers, C. M., Tissing, W. J.E., Versluys, A. B., Van Der Heiden-Van Der Loo, M., Heijboer, A. C., Hauptmann, M., Twisk, J. W.R., Laven, J. S.E., Beerendonk, C. C.M., Van Leeuwen, F. E., Van Dulmen-Den Broeder, E., Child Health, Haematologie patientenzorg, Van Den Berg, M. H., Overbeek, A., Lambalk, C. B., Kaspers, G. J.L., Bresters, D., Van Den Heuvel-Eibrink, M. M., Kremer, L. C., Loonen, J. J., Van Der Pal, H. J., Ronckers, C. M., Tissing, W. J.E., Versluys, A. B., Van Der Heiden-Van Der Loo, M., Heijboer, A. C., Hauptmann, M., Twisk, J. W.R., Laven, J. S.E., Beerendonk, C. C.M., Van Leeuwen, F. E., and Van Dulmen-Den Broeder, E.

Published
2018

34. Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma

Author

Clement, S. C., Schoot, R. A., Slater, O., Chisholm, J. C., Abela, C., Balm, A. J M, Van Den Brekel, M. W., Breunis, W. B., Chang, Y. C., Davila Fajardo, R., Dunaway, D., Gajdosova, E., Gaze, M. N., Gupta, S., Hartley, B., Kremer, L. C M, Van Lennep, M., Levitt, G. A., Mandeville, H. C., Pieters, B. R., Saeed, P., Smeele, L. E., Strackee, S. D., Ronckers, C. M., Caron, H. N., Van Santen, H. M., Merks, J. H M, Clement, S. C., Schoot, R. A., Slater, O., Chisholm, J. C., Abela, C., Balm, A. J M, Van Den Brekel, M. W., Breunis, W. B., Chang, Y. C., Davila Fajardo, R., Dunaway, D., Gajdosova, E., Gaze, M. N., Gupta, S., Hartley, B., Kremer, L. C M, Van Lennep, M., Levitt, G. A., Mandeville, H. C., Pieters, B. R., Saeed, P., Smeele, L. E., Strackee, S. D., Ronckers, C. M., Caron, H. N., Van Santen, H. M., and Merks, J. H M

Published
2016

35. Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma

Author

Endocrinologie onderzoek, Child Health, MS Radiotherapie, Endocrinologie patientenzorg, PMC Medisch specialisten, Clement, S. C., Schoot, R. A., Slater, O., Chisholm, J. C., Abela, C., Balm, A. J M, Van Den Brekel, M. W., Breunis, W. B., Chang, Y. C., Davila Fajardo, R., Dunaway, D., Gajdosova, E., Gaze, M. N., Gupta, S., Hartley, B., Kremer, L. C M, Van Lennep, M., Levitt, G. A., Mandeville, H. C., Pieters, B. R., Saeed, P., Smeele, L. E., Strackee, S. D., Ronckers, C. M., Caron, H. N., Van Santen, H. M., Merks, J. H M, Endocrinologie onderzoek, Child Health, MS Radiotherapie, Endocrinologie patientenzorg, PMC Medisch specialisten, Clement, S. C., Schoot, R. A., Slater, O., Chisholm, J. C., Abela, C., Balm, A. J M, Van Den Brekel, M. W., Breunis, W. B., Chang, Y. C., Davila Fajardo, R., Dunaway, D., Gajdosova, E., Gaze, M. N., Gupta, S., Hartley, B., Kremer, L. C M, Van Lennep, M., Levitt, G. A., Mandeville, H. C., Pieters, B. R., Saeed, P., Smeele, L. E., Strackee, S. D., Ronckers, C. M., Caron, H. N., Van Santen, H. M., and Merks, J. H M

Published
2016

36. PO-0771: Temporal changes in pediatric radiation oncology: DCOG LATER childhood cancer survivor study

Author

Kok, J., primary, Dolsma, W., additional, Van Dulmen-den Broeder, E., additional, Van den Heuvel-Eibrink, M., additional, Loonen, J., additional, Tissing, W., additional, Bresters, D., additional, Versluys, B., additional, Van der Pal, H., additional, Neggers, S., additional, Hollema, N., additional, Van der Heiden-van der Loo, M., additional, Van Leeuwen, F., additional, Oldenburger, F., additional, Aleman, B., additional, Janssens, G., additional, Maduro, J., additional, Tersteeg, R., additional, Van Rij, C., additional, Daniels, L., additional, Haasbeek, C., additional, Caron, H., additional, Kremer, L., additional, and Ronckers, C., additional

Published
2016
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37. PO-0770: Subsequent colorectal adenomas in childhood cancer survivors: a DCOG LATER record linkage study

Author

Teepen, J., primary, Kok, J., additional, Van Leeuwen, F., additional, Tissing, W., additional, Dolsma, W., additional, Van der Pal, H., additional, Van Dulmen-den Broeder, E., additional, Van den Heuvel-Eibrink, M., additional, Loonen, J., additional, Bresters, D., additional, Versluys, A., additional, Neggers, S., additional, De Vries, A., additional, Jaspers, M., additional, Van den Berg, M., additional, Caron, H., additional, Van der Heiden-van der Loo, M., additional, Hollema, N., additional, Oldenburger, F., additional, Visser, O., additional, Overbeek, L., additional, Kremer, L., additional, and Ronckers, C., additional

Published
2016
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38. OC-0542: Benign tumours among long-term childhood cancer survivors: a DCOG LATER record linkage study

Author

Kok, J., primary, Teepen, J., additional, Van der Pal, H., additional, Dolsma, W., additional, Van Dulmen-den Broeder, E., additional, Van den Heuvel-Eibrink, M., additional, Loonen, J., additional, Tissing, W., additional, Bresters, D., additional, Versluys, B., additional, Neggers, S., additional, Van der Heiden-van der Loo, M., additional, Van Leeuwen, F., additional, Caron, H., additional, Oldenburger, F., additional, Janssens, G., additional, Maduro, J., additional, Tersteeg, R., additional, Van Rij, C., additional, Daniels, L., additional, Haasbeek, C., additional, Gijsbers-Bruggink, A., additional, Kremer, L., additional, and Ronckers, C., additional

Published
2016
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39. Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma - A systematic review

Author

Clement, S C, Peeters, R P, Ronckers, C M, Links, T P, van den Heuvel-Eibrink, M M, Nieveen van Dijkum, E J M, van Rijn, R R, van der Pal, H J H, Neggers, S J, Kremer, L C M, van Eck-Smit, B L F, van Santen, H M, Clement, S C, Peeters, R P, Ronckers, C M, Links, T P, van den Heuvel-Eibrink, M M, Nieveen van Dijkum, E J M, van Rijn, R R, van der Pal, H J H, Neggers, S J, Kremer, L C M, van Eck-Smit, B L F, and van Santen, H M

Published
2015

40. Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma - A systematic review

Author

Endocrinologie patientenzorg, Child Health, Endocrinologie onderzoek, Clement, S C, Peeters, R P, Ronckers, C M, Links, T P, van den Heuvel-Eibrink, M M, Nieveen van Dijkum, E J M, van Rijn, R R, van der Pal, H J H, Neggers, S J, Kremer, L C M, van Eck-Smit, B L F, van Santen, H M, Endocrinologie patientenzorg, Child Health, Endocrinologie onderzoek, Clement, S C, Peeters, R P, Ronckers, C M, Links, T P, van den Heuvel-Eibrink, M M, Nieveen van Dijkum, E J M, van Rijn, R R, van der Pal, H J H, Neggers, S J, Kremer, L C M, van Eck-Smit, B L F, and van Santen, H M

Published
2015

41. IARC monographs: 40 years of evaluating carcinogenic hazards to humans

Author

Pearce, N., Blair, A., Vineis, P., Ahrens, W., Andersen, A., Anto, J., Armstrong, B., Baccarelli, A., Beland, F., Berrington, A., Bertazzi, P., Birnbaum, L., Brownson, R., Bucher, J., Cantor, K., Cardis, E., Cherrie, J., Christiani, D., Cocco, P., Coggon, D., Comba, P., Demers, P., Dement, J., Douwes, J., Eisen, E., Engel, L., Fenske, R., Fleming, L., Fletcher, T., Fontham, E., Forastiere, F., Frentzel-Beyme, R., Fritschi, Lin, Gerin, M., Goldberg, M., Grandjean, P., Grimsrud, T., Gustavsson, P., Haines, A., Hartge, P., Hansen, J., Hauptmann, M., Heederik, D., Hemminki, K., Hemon, D., Hertz-Picciotto, I., Hoppin, J., Huff, J., Jarvholm, B., Kang, D., Karagas, M., Kjaerheim, K., Kjuus, H., Kogevinas, M., Kriebel, D., Kristensen, P., Kromhout, H., Laden, F., Lebailly, P., Lemasters, G., Lubin, J., Lynch, C., Lynge, E., Mannetje, A., McMichael, A., McLaughlin, J., Marrett, L., Martuzzi, M., Merchant, J., Merler, E., Merletti, F., Miller, A., Mirer, F., Monson, R., Nordby, K., Olshan, A., Parent, M., Perera, F., Perry, M., Pesatori, A., Pirastu, R., Porta, M., Pukkala, E., Rice, C., Richardson, D., Ritter, L., Ritz, B., Ronckers, C., Rushton, L., Rusiecki, J., Rusyn, I., Samet, J., Sandler, D., de Sanjose, S., Schernhammer, E., Costantini, A., Seixas, N., Shy, C., Siemiatycki, J., Silverman, D., Simonato, L., Smith, A., Smith, M., Spinelli, J., Spitz, M., Stallones, L., Stayner, L., Steenland, K., Stenzel, M., Stewart, B., Stewart, P., Symanski, E., Terracini, B., Tolbert, P., Vainio, H., Vena, J., Vermeulen, R., Victora, C., Ward, E., Weinberg, C., Weisenburger, D., Wesseling, C., Weiderpass, E., Zahm, S., Pearce, N., Blair, A., Vineis, P., Ahrens, W., Andersen, A., Anto, J., Armstrong, B., Baccarelli, A., Beland, F., Berrington, A., Bertazzi, P., Birnbaum, L., Brownson, R., Bucher, J., Cantor, K., Cardis, E., Cherrie, J., Christiani, D., Cocco, P., Coggon, D., Comba, P., Demers, P., Dement, J., Douwes, J., Eisen, E., Engel, L., Fenske, R., Fleming, L., Fletcher, T., Fontham, E., Forastiere, F., Frentzel-Beyme, R., Fritschi, Lin, Gerin, M., Goldberg, M., Grandjean, P., Grimsrud, T., Gustavsson, P., Haines, A., Hartge, P., Hansen, J., Hauptmann, M., Heederik, D., Hemminki, K., Hemon, D., Hertz-Picciotto, I., Hoppin, J., Huff, J., Jarvholm, B., Kang, D., Karagas, M., Kjaerheim, K., Kjuus, H., Kogevinas, M., Kriebel, D., Kristensen, P., Kromhout, H., Laden, F., Lebailly, P., Lemasters, G., Lubin, J., Lynch, C., Lynge, E., Mannetje, A., McMichael, A., McLaughlin, J., Marrett, L., Martuzzi, M., Merchant, J., Merler, E., Merletti, F., Miller, A., Mirer, F., Monson, R., Nordby, K., Olshan, A., Parent, M., Perera, F., Perry, M., Pesatori, A., Pirastu, R., Porta, M., Pukkala, E., Rice, C., Richardson, D., Ritter, L., Ritz, B., Ronckers, C., Rushton, L., Rusiecki, J., Rusyn, I., Samet, J., Sandler, D., de Sanjose, S., Schernhammer, E., Costantini, A., Seixas, N., Shy, C., Siemiatycki, J., Silverman, D., Simonato, L., Smith, A., Smith, M., Spinelli, J., Spitz, M., Stallones, L., Stayner, L., Steenland, K., Stenzel, M., Stewart, B., Stewart, P., Symanski, E., Terracini, B., Tolbert, P., Vainio, H., Vena, J., Vermeulen, R., Victora, C., Ward, E., Weinberg, C., Weisenburger, D., Wesseling, C., Weiderpass, E., and Zahm, S.

Abstract

Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans. oBjectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed. discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed. conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health.

Published
2015

42. Long-term effects of childhood cancer treatment on hormonal and ultrasound markers of ovarian reserve.

Author

Berg, M H van den, Overbeek, A, Lambalk, C B, Kaspers, G J L, Bresters, D, Heuvel-Eibrink, M M van den, Kremer, L C, Loonen, J J, Pal, H J van der, Ronckers, C M, van den Berg, M H, van den Heuvel-Eibrink, M M, van der Pal, H J, Tissing, W J E, Versluys, A B, van der Heiden-van der Loo, M, Heijboer, A C, Hauptmann, M, Twisk, J W R, and Laven, J S E

Subjects
CHILDHOOD cancer, OVARIAN reserve, ULTRASONIC imaging, RADIOTHERAPY, SPINE, CANCER treatment, TUMOR treatment, RESEARCH, HORMONES, PREDICTIVE tests, TIME, RESEARCH methodology, ANTINEOPLASTIC agents, RETROSPECTIVE studies, EVALUATION research, MEDICAL cooperation, INFERTILITY, RISK assessment, COMPARATIVE studies, RADIATION injuries, PHYSIOLOGICAL effects of radiation
Abstract

Study Question: Which treatment-related factors are (dose-dependently) associated with abnormal hormonal and ultrasound markers of ovarian reserve in female childhood cancer survivors (CCSs)?Summary Answer: Cyclophosphamide, procarbazine, a composite group of 'other alkylating agents', dactinomycin, doxorubicin, mitoxantrone, spinal radiotherapy (RT), abdominal/pelvic RT and total body irradiation were multivariably associated with abnormal ovarian reserve markers, with dose-effect relationships being established for procarbazine and abdominal/pelvic RT.What Is Known Already: Female childhood cancer survivors are at an increased risk of reduced ovarian function and reserve, but knowledge regarding the long-term effects of individual chemotherapeutic (CT) agents and radiotherapy fields and their respective doses is limited.Study Design, Size, Duration: The DCOG LATER-VEVO is a nationwide retrospective cohort study in which measurements were performed between 2008 and 2014. In total, 1749 female 5-year CCSs, diagnosed before age 18 years between 1963 and 2002 and 1201 controls were invited for the study.Participants/materials, Setting, Methods: Ovarian reserve was assessed by anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), inhibin B levels, and antral follicle counts (AFC). The study was a multicentre study including all seven Dutch Centers for Paediatric Oncology/Haematology.Main Results and the Role Of Chance: In total, 564 CCs and 390 controls participated in the clinical part of the study. Overall, 7.0-17.7% of CCSs and 2.4-13.6% of controls had abnormal ovarian reserve markers. Above age 35, significantly more CCSs than controls had abnormal ovarian reserve markers (AMH: 26% vs. 4%; AFC: 20% vs. 3%; inhibin B: 42% vs. 16%). For AMH and FSH, significant differences were also found below age 35. Cyclophosphamide, procarbazine, a group of 'other alkylating agents', dactinomycin, doxorubicin, mitoxantrone, spinal RT, abdominal/pelvic RT and total body irradiation were multivariably associated with at least one abnormal ovarian reserve marker. Dose-effect relationships were established for procarbazine and abdominal/pelvic RT.Limitations, Reasons For Caution: Despite the large scale of the study, dose-effect relationships could not be investigated for all types of treatment due to a limited numbers of participants for specific analyses.Wider Implications Of the Findings: This study demonstrated that the majority of CCSs do not show signs of a reduced ovarian reserve. However, specific subgroups of CCSs appear to be associated with a high risk. Our results are important for counselling CCSs and future patients regarding parenthood and fertility preservation.Study Funding/competing Interests: This study was funded by the Dutch Cancer Society (Grant no. VU 2006-3622) and by the Children Cancer Free Foundation (Project no. 20). Philips Health Systems Benelux supported this study by providing three ultrasound systems and concomitant analytic software. There are no competing interests.Trial Registration Number: NTR2922 http://www.trialregister.nl/trialreg/admin/rctview.asp?TC = 2922. [ABSTRACT FROM AUTHOR]

Published
2018
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43. SP-0171: Pediatric Normal Tissue Effects in the Clinic (PENTEC): An international collaboration

Author

Ronckers, C., primary, Constine, L., additional, Bentzen, S.M., additional, Dhakal, S., additional, Hodgson, D., additional, Hua, C.H., additional, Hudson, M.M., additional, Kremer, L.C.M., additional, Martel, M., additional, Milano, M., additional, Olch, A.J., additional, Schultheiss, T., additional, Stovall, M., additional, Ten Haken, R., additional, Williams, J.P., additional, and Yorke, E., additional

Published
2015
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44. Fertility studies in female childhood cancer survivors: selecting appropriate comparison groups

Author

Berg, M. van den, Dulmen-den Broeder, E. van, Overbeek, A., Ronckers, C., Dorp, W. van, Kremer, L., Heuvel-Eibrink, M. van den, Huizinga, G., Loonen, J.J., Versluys, A., Bresters, D., Lambalk, C., Kaspers, G., Leeuwen, F.N. van, Berg, M. van den, Dulmen-den Broeder, E. van, Overbeek, A., Ronckers, C., Dorp, W. van, Kremer, L., Heuvel-Eibrink, M. van den, Huizinga, G., Loonen, J.J., Versluys, A., Bresters, D., Lambalk, C., Kaspers, G., and Leeuwen, F.N. van

Abstract

Item does not contain fulltext, Little information is available on the use of appropriate comparison groups for studies investigating late effects of childhood cancer. Two comparison groups in a nationwide study on reproductive function and ovarian reserve in female childhood cancer survivors were recruited (The Dutch Childhood Oncology Group Long-Term Effects After Childhood Cancer Cohort Study). Experiences of this process are reported. Two types of comparison groups were used: sisters of participating survivors and controls from the general population. A total of 352 out of 580 (61%) of the participating survivors who had a sister gave permission to invite them for the study. The participation rate of sisters was much higher than control participants from the general population (74% versus 21%, respectively), whereas considerably more effort was involved in recruiting controls from the general population. Participants in this group were significantly older and more highly educated than sister controls (P < 0.001 for both groups). No significant differences were observed between both types of comparison groups in several fertility-related characteristics, suggesting minimal bias owing to selective participation. Researchers setting up a study to investigate late effects among survivors of childhood cancer should carefully consider the advantages and disadvantages of using various types of comparison groups.

Published
2014

45. Geen overtuigend bewijs voor een causaal verband tussen nasofaryngeale radiumbestraling op de kinderleeftijd en latere hoofd-halstumoren en hormonale aandoeningen; een historisch cohortonderzoek

Author

Ronckers, C. M., Verduijn, P. G., Land, C. E., Hayes, R. B., Stovall, M., van Leeuwen, F. E., and Paediatric Oncology

Abstract

To study the risk of malignant and benign tumours and hormone-related disorders among patients treated with nasopharyngeal radium irradiation for hypertrophic adenoid or hearing loss caused by otitis media serosa. Retrospective cohort study. The medical record registries of 9 hospitals were used to identify a radium-exposed group (n = 5358) and a control group of unexposed patients (n = 5265), who were treated by an otolaryngologist in the period 1945-1981. The vital status of the subjects was determined using municipal resident registries, and the cause of death of decedents was retrieved from Statistics Netherlands (1950-1997). The data was also coupled with the Netherlands Cancer Registry (1989-1996). For the subjects still alive in 1997, the prevalence of relevant disorders was determined using a self-administered questionnaire and disorders reported by the participants were medically verified. The risk of disease in the radium group was then compared with that of the control group. The average radiation doses were 2.75, 0.109 and 0.015 Gy for nasopharynx, pituitary, and thyroid, respectively. There was no statistically significantly elevated risk for malignancies of the head and neck area (radium-exposed group; n = 14; control group: n = 11 (relative risk (RR): 1.2; 95% CI: 0.6-2.8)). Four of the five thyroid carcinomas were found in the radium-exposed group (RR: 3.8; 0.5-76). Elevated risks were observed for breast cancer (RR: 1.6; 0.9-2.7) and non-Hodgkin's lymphoma (RR: 2.7; 1.0-8.7). There was an increased risk for skin basal cell carcinoma (BCC) of the head and neck (odds ratio (OR): 2.6; 1.0-6.7), but the risk of BCC of other body parts was lower (OR: 0.3; 0.1-1.3). There were no major differences between radium and control subjects with respect to benign head and neck tumours (OR: 1.0; 0.5-1.7) or hormonal disorders. Exposed men reported slightly more fertility disorders than men in the control group (OR: 1.4; 1.0-2.1), but there was no clear dose-response relationship. After a mean follow-up of 31 years, there was no strong evidence for an elevated risk of head and neck tumours or hormone-related disorders in adulthood among subjects who had been treated with nasopharyngeal radium irradiation during childhood

Published
2004

46. Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Author

Thierry-Chef Isabelle, Timmermann Beate, Journy Neige, Bernier Marie-Odile, McNally Richard, Dabin Jérémie, Brualla Lorenzo, Haghdoost Siamak, Sarukhan Adelaida, Haustermans Karin, De Wit Inge, Isebaert Sofie, Lassen-Ramshad Yasmin, Tram Henriksen Louise, Høyer Morten, Toussaint Laura, Boissonnat Guillaume, Thariat Juliette, Demoor-Goldschmidt Charlotte, Haddy Nadia, Bolle Stéphanie, Fresneau Brice, Belhout Amel, Dreger Steffen, Zeeb Hajo, Grazia Andreassi Maria, Campolo Jonica, Picano Eugenio, Jahnen Andreas, Ronckers Cécile, Maduro John H., Kjaerheim Kristina, Døhlen Gaute, Robsahm Trude Eid, Olerud Hilde M., Thevathas Utheya Salini, Afroz Susmita, Helge Østerås Bjørn, Schneider Uwe, Walsh Linda, Dumas Agnès, Jackson Angéla, Rage Estelle, De Saint-Hubert Marijke, Hardy Richard, Bäumer Christian, Steinmeier Theresa, Botzenhardt Suzan, Wette Martina, Ortiz Rodney, and Chumak Vadim

Subjects
Nuclear engineering. Atomic power, TK9001-9401
Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Published
2023
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48. Height, weight weight change, and postmenopausal breast cancer risk: The Netherlands Cohort Study

Author

van den Brandt, P. A., Dirx, M. J., Ronckers, C. M., van den Hoogen, P., Goldbohm, R. A., and Other departments

Abstract

The association between several anthropometric indices and breast cancer risk was evaluated within the Netherlands Cohort Study on diet and cancer, which began in 1986 and is conducted among 62,573 women aged 55 to 69 years at baseline. After 4.3 years of follow-up, data on 626 women with incident breast cancer were available with complete information on height and weight at baseline. In multivariate case-cohort analyses, a significantly positive association between adult height and breast cancer was found (P trend or = 175 cm were 1.22, 1.19, 1.44, 1.77, and 2.06, respectively. For weight at baseline, the significant positive association with breast cancer observed in age-adjusted analysis disappeared in multivariate analysis with adjustment for height and other confounders. For body mass index (BMI) (wt[kg]/ht[m]2) at baseline, no association was observed with breast cancer in multivariate analysis; compared with women with a BMI less than 23, the RR for women with a BMI of 30 or more was 0.98 with P trend = 0.46. Weight and BMI at age 20 showed weak inverse associations with breast cancer risk. For gain in weight or BMI between age 20 and cohort baseline age, inconsistent increases in risk were found, with no significant trends. These data support a positive association between height and breast cancer risk among postmenopausal women. Further study is needed to evaluate the role of early diet and breast cancer in this population, and its relationship to height

Published
1997

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