169 results on '"Rojas, Winston"'
Search Results
2. Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape
- Author
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Li, Qing, Chen, Jieyi, Faux, Pierre, Delgado, Miguel Eduardo, Bonfante, Betty, Fuentes-Guajardo, Macarena, Mendoza-Revilla, Javier, Chacón-Duque, J. Camilo, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Jaramillo, Claudia, Arias, William, Barquera, Rodrigo, Everardo-Martínez, Paola, Sánchez-Quinto, Mirsha, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Silva de Cerqueira, Caio C., Hünemeier, Tábita, Ramallo, Virginia, Wu, Sijie, Du, Siyuan, Giardina, Andrea, Paria, Soumya Subhra, Khokan, Mahfuzur Rahman, Gonzalez-José, Rolando, Schüler-Faccini, Lavinia, Bortolini, Maria-Cátira, Acuña-Alonzo, Victor, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Rojas, Winston, Rothhammer, Francisco, Navarro, Nicolas, Wang, Sijia, Adhikari, Kaustubh, and Ruiz-Linares, Andrés
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- 2023
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3. Assessment of Cytotoxicity and Genotoxicity Induced by Diesel Exhaust Particles (DEPs) on Cell Line A549 and the Potential Role of Amide-Functionalized Carbon Nanotubes as Fuel Additive.
- Author
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Pino, Juan Sebastian, Alvarado, Pedro Nel, Rojas, Winston, Cacua, Karen, and Gomez-Lopera, Natalia
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POISONS ,SCANNING transmission electron microscopy ,CARBON nanotubes ,CYTOTOXINS ,POLYCYCLIC aromatic hydrocarbons ,AIR pollution - Abstract
Epidemiological studies have consistently linked air pollution to severe health risks. One strategy to reduce the impact of combustion products from engines is adding additives to the fuel. Potential benefits have been observed in terms of performance and emissions, as well as in decreasing fuel consumption. However, the associated emission of particulate matter into the environment may have unforeseen health effects. This study examines the effects of diesel exhaust particles (DEPs) from diesel fuel mixed with amide-functionalized carbon nanotubes (CNTF). The aim is to analyze the properties of DEPs and determine their toxic effects on lung cells. The DEPs were characterized using scanning and transmission electron microscopy, while the polycyclic aromatic hydrocarbons (PAHs) were analyzed through gas chromatography. Various assays were conducted to assess cell viability, apoptosis, oxidative stress, and DNA damage. The addition of CNTF to diesel fuel altered the morphology and size of the particles, as well as the quantity and composition of PAHs. At the cellular level, diesel DEPs induce higher levels of reactive oxygen species (ROS) production, DNA damage, apoptosis, and cytotoxicity compared to both CNTF and diesel–CNTF DEPs. These findings suggest that the nano-additives enhance energy efficiency by reducing pollutants without significantly increasing cell toxicity. [ABSTRACT FROM AUTHOR]
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- 2024
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- View/download PDF
4. Reconstructing Native American population history
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Reich, David, Patterson, Nick, Campbell, Desmond, Tandon, Arti, Mazieres, Stéphane, Ray, Nicolas, Parra, Maria V, Rojas, Winston, Duque, Constanza, Mesa, Natalia, García, Luis F, Triana, Omar, Blair, Silvia, Maestre, Amanda, Dib, Juan C, Bravi, Claudio M, Bailliet, Graciela, Corach, Daniel, Hünemeier, Tábita, Bortolini, Maria Cátira, Salzano, Francisco M, Petzl-Erler, María Luiza, Acuña-Alonzo, Victor, Aguilar-Salinas, Carlos, Canizales-Quinteros, Samuel, Tusié-Luna, Teresa, Riba, Laura, Rodríguez-Cruz, Maricela, Lopez-Alarcón, Mardia, Coral-Vazquez, Ramón, Canto-Cetina, Thelma, Silva-Zolezzi, Irma, Fernandez-Lopez, Juan Carlos, Contreras, Alejandra V, Jimenez-Sanchez, Gerardo, Gómez-Vázquez, Maria José, Molina, Julio, Carracedo, Ángel, Salas, Antonio, Gallo, Carla, Poletti, Giovanni, Witonsky, David B, Alkorta-Aranburu, Gorka, Sukernik, Rem I, Osipova, Ludmila, Fedorova, Sardana A, Vasquez, René, Villena, Mercedes, Moreau, Claudia, Barrantes, Ramiro, Pauls, David, Excoffier, Laurent, Bedoya, Gabriel, Rothhammer, Francisco, Dugoujon, Jean-Michel, Larrouy, Georges, Klitz, William, Labuda, Damian, Kidd, Judith, Kidd, Kenneth, Di Rienzo, Anna, Freimer, Nelson B, Price, Alkes L, and Ruiz-Linares, Andrés
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Human Society ,Historical Studies ,Anthropology ,American Indian or Alaska Native ,Americas ,Asia ,Cluster Analysis ,Emigration and Immigration ,Gene Flow ,Genetics ,Population ,History ,Ancient ,Humans ,Indians ,North American ,Models ,Genetic ,Phylogeny ,Polymorphism ,Single Nucleotide ,Siberia ,General Science & Technology - Abstract
The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call 'First American'. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.
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- 2012
5. Tautología genética entre neurodesarrollo y neurodegeneración
- Author
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Acosta-Baena, Natalia, Tejada-Moreno, Johanna, Mejía, Alejandro, Preciado, Mauricio, Madrigal, Lucia, Caro, María Antonieta, Rojas, Winston, Arcos-Burgos, Mauricio, and Lanau, Carlos Andrés Villegas
- Published
- 2022
6. Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry
- Author
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Yang, Guangrui, primary, Chen, Yingjie, additional, Li, Qing, additional, Benítez, Daniel, additional, Ramírez, Luis Miguel, additional, Fuentes-Guajardo, Macarena, additional, Hanihara, Tsunehiko, additional, Scott, G. Richard, additional, Acuña Alonzo, Victor, additional, Gonzalez Jose, Rolando, additional, Bortolini, Maria Catira, additional, Poletti, Giovanni, additional, Gallo, Carla, additional, Rothhammer, Francisco, additional, Rojas, Winston, additional, Zanolli, Clément, additional, Adhikari, Kaustubh, additional, Ruiz-Linares, Andres, additional, and Delgado, Miguel, additional
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- 2023
- Full Text
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7. Geographic patterns of genome admixture in Latin American Mestizos.
- Author
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Wang, Sijia, Ray, Nicolas, Rojas, Winston, Parra, Maria V, Bedoya, Gabriel, Gallo, Carla, Poletti, Giovanni, Mazzotti, Guido, Hill, Kim, Hurtado, Ana M, Camrena, Beatriz, Nicolini, Humberto, Klitz, William, Barrantes, Ramiro, Molina, Julio A, Freimer, Nelson B, Bortolini, Maria Cátira, Salzano, Francisco M, Petzl-Erler, Maria L, Tsuneto, Luiza T, Dipierri, José E, Alfaro, Emma L, Bailliet, Graciela, Bianchi, Nestor O, Llop, Elena, Rothhammer, Francisco, Excoffier, Laurent, and Ruiz-Linares, Andrés
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Chromosomes ,Human ,X ,Humans ,Genetics ,Population ,Microsatellite Repeats ,Heterozygote ,Genome ,Human ,African Continental Ancestry Group ,American Native Continental Ancestry Group ,European Continental Ancestry Group ,Latin America ,Female ,Male ,Genetic Variation ,Chromosomes ,Human ,X ,Genetics ,Population ,Genome ,Developmental Biology - Abstract
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.
- Published
- 2008
8. Underwater Glider Observations in the Oxygen Minimum Zone off Central Chile
- Author
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Pizarro, Oscar, Ramírez, Nadin, Castillo, Manuel I., Cifuentes, Ursula, Rojas, Winston, and Pizarro-Koch, Matias
- Published
- 2016
9. Estudio de la variación genética de la ruta isomerasa del D-galacturonato y análisis estructural de la enzima UxaA (D-altronato deshidratasa) para la transformación de residuos agroindustriales ricos en pectinas a etanol.
- Author
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David Mejía, Simón, Sánchez, Julián A., Soto-Ospina, Alejandro, Rojas, Winston, and Alberto Ríos-Osorio, Leonardo
- Subjects
BODIES of water ,LACTOCOCCUS lactis ,ISOMERASES ,WATER pollution ,GENETIC variation - Abstract
Copyright of Producción Más Limpia is the property of Corporacion Universitaria Lasallista and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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10. Multilocus Sequence Typing helps understand the genetic diversity of Cryptosporidium hominis and Cryptosporidium parvum isolated from Colombian patients
- Author
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Uran-Velasquez, Johanna, primary, Alzate, Juan F., additional, Farfan-Garcia, Ana E., additional, Gomez-Duarte, Oscar G., additional, Martinez-Rosado, Larry L., additional, Dominguez-Hernandez, Diego D., additional, Rojas, Winston, additional, Galvan-Diaz, Ana Luz, additional, and Garcia-Montoya, Gisela M., additional
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- 2022
- Full Text
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11. Fully automatic landmarking of 2D photographs identifies novel genetic loci influencing facial features
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Li, Qing, primary, Chen, Jieyi, additional, Faux, Pierre, additional, Bonfante, Betty, additional, Fuentes-Guajardo, Macarena, additional, Mendoza-Revilla, Javier, additional, Chacón-Duque, Juan, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Jaramillo, Claudia, additional, Arias, William, additional, Barquera, Rodrigo, additional, Everardo-Martínez, Paola, additional, Sánchez-Quinto, Mirsha, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, de Cerqueira, Caio C. Silva, additional, Hünemeier, Tábita, additional, Ramallo, Virginia, additional, Wu, Sijie, additional, Du, Siyuan, additional, Gonzalez-José, Rolando, additional, Schüler-Faccini, Lavinia, additional, Bortolini, Maria-Cátira, additional, Acuña-Alonzo, Victor, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Rojas, Winston, additional, Rothhammer, Francisco, additional, Navarro, Nicolas, additional, Wang, Sijia, additional, Adhikari, Kaustubh, additional, and Ruiz-Linares, Andrés, additional
- Published
- 2022
- Full Text
- View/download PDF
12. Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
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Rojas, Winston, Parra, Maria Victoria, Campo, Omer, Caro, Maria Antonieta, Lopera, Juan Guillermo, Arias, William, Duque, Constanza, Naranjo, Andres, Garcia, Jharley, Vergara, Candelaria, Lopera, Jaime, Hernandez, Erick, Valencia, Ana, Caicedo, Yuri, Cuartas, Mauricio, Gutierrez, Javier, Lopez, Sergio, Ruiz-Linares, Andres, and Bedoya, Gabriel
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Genetic markers -- Research ,Human population genetics -- Research ,Anthropology/archeology/folklore - Abstract
Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X-Chromosome), maternal (mtDNA), and paternal (Y-chromosome) markers. Autosomal ancestry varies markedly both within and between regions, confirming the great genetic diversity of the Colombian population. The X-chromosome, mtDNA, and Y-chromosome data indicate that there is a pattern across regions indicative of admixture involving predominantly Native American women and European and African men. Am J Phys Anthropol 143:13-20, 2010. KEY WORDS Colombia; mestizo; genetic markers; admixture DOI 10.1002/ajpa.21270
- Published
- 2010
13. African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia
- Author
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Vergara, Candelaria, Caraballo, Luis, Mercado, Dilia, Jimenez, Silvia, Rojas, Winston, Rafaels, Nicholas, Hand, Tracey, Campbell, Monica, Tsai, Yuhjung J., Gao, Li, Duque, Constanza, Lopez, Sergio, Bedoya, Gabriel, Ruiz-Linares, Andrés, and Barnes, Kathleen C.
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- 2009
- Full Text
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14. Analisis genetico de una poblacion urbana de Lutzomyia evansi (Diptera: Psychodidae), recientemente detectada en Colombia
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Bejarano, Eduar ElÃas, Rojas, Winston, Uribe, Sandra, Vélez, Iván DarÃo, and Porter, Charles H.
- Published
- 2009
15. Contrasting Patterns of Nuclear and mtDNA Diversity in Native American Populations
- Author
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Yang, Ning Ning, Mazières, Stephane, Bravi, Claudio, Ray, Nicolas, Wang, Sijia, Burley, Mari-Wyn, Bedoya, Gabriel, Rojas, Winston, Parra, Maria V., Molina, Julio A., Gallo, Carla, Poletti, Giovanni, Hill, Kim, Hurtado, Ana M., Petzl-Erler, Maria L., Tsuneto, Luiza T., Klitz, William, Barrantes, Ramiro, Llop, Elena, Rothhammer, Francisco, Labuda, Damian, Salzano, Francisco M., Bortolini, Maria-Cátira, Excoffier, Laurent, Dugoujon, Jean Michel, and Ruiz-Linares, Andrés
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- 2010
- Full Text
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16. Phylogenetics of South American Biomphalaria and description of a new species (Gastropoda: Planorbidae)
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Estrada, Victoria E., Velásquez, Luz E., Caldeira, Roberta L., Bejarano, Eduar E., Rojas, Winston, Carvalho, Omar S., and The Malacological Society of London.
- Subjects
Species ,Biomphalaria ,Schistosoma mansoni - Abstract
Artículo digital., The planorbid snail Biomphalaria edisoni n. sp. is described from morphological and molecular characters, based on specimens collected at two localities in Colombia. The new species has the typical features of the genus, as well as the following characteristics: vaginal pouch, numerous prostatic diverticular arranged in racemes, penis sheath/prepuce ratio of approximately 2 and a penial complex half the length of the cephalic portion of the female duct. These elements differentiate it from B. kuhniana, which was also present in one of the localities, and also from B. prona,B. helophila and B. nicaraguana, with which it has greater morphological similarities. Phylogenetic analysis of the nucleotide sequences of the internal spacers of the ribosomal DNA transcript (ITS1, ITS2) of B. edisoni n. sp. and 14 neotro-pical Biomphalaria species indicates that the former belongs to the monophyletic group including B. prona and B. sp. from Cuba. The genetic distances within this monophyletic group are however great enough for B. edisoni n. sp. to be regarded as a separate species. Thus morphology, phylogenetic tree topology and genetic distances all support the recognition of B. edisoni as a new species.
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- 2019
17. Evaluación de las variantes en los genes IL6R, TLR3 y DC-SIGN asociadas con dengue en una muestra de población colombiana
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Avendaño-Tamayo, Efrén, Rúa, Alex, Parra-Marín, María Victoria, Rojas, Winston, Campo, Omer, Chacón-Duque, Juan, Agudelo-Flórez, Piedad, Narváez, Carlos F., Salgado, Doris M., Restrepo, Bertha Nelly, and Bedoya, Gabriel
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polymorphism, genetic ,toll-like receptor 3 ,Colombia ,Dengue/genetics - Abstract
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease. Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN. Materials and methods: Of the 292 surveyed subjects, 191 were confirmed for dengue fever and the remaining 101 were included as controls. The genotypes were resolved using polymerase chain reaction and restriction fragment length polymorphism (PCR- RFLP). In an attempt to determine the risk (Odds Ratio) of suffering dengue fever, data were analyzed using chi-square for alleles and logistic regression for both genotypes and allelic combinations. Confidence intervals were set to 95% for all tests regardless of the adjustment by either self-identification or ancestry. Results: For Afro-Colombians, the allele rs8192284 C offered protection against dengue [OR=0.425,(0.204-0.887), p=0.020]. The alleles rs7248637 A and rs3775290 A posed, respectively, an increased risk of dengue for Afro-Colombians [OR=2.389, (1.170-4.879), p=0.015] and Mestizos [OR=2.329, (1.283-4.226), p=0.005]. The reproducibility for rs8192284 C/C [OR=2.45, (1.05-5.76), p=0.013] remained after adjustment by Amerindian ancestry [OR=2.52, (1.04-6.09), p=0.013]. The reproducibility for rs3775290 A/A [OR=2.48, (1.09-5.65), p=0.033] remained after adjustment by European [OR=2.34, (1.02-5.35), p=0.048], Amerindian [OR=2.49, (1.09-5.66), p=0.035], and African ancestry [OR=2.37, (1.04-5.41), p=0.046]. Finally, the association of dengue fever with the allelic combination CAG [OR=2.07, (1.06-4.05), p=0.033] remained after adjustment by Amerindian ancestry [OR=2.16, (1.09-4.28), p=0.028]. Conclusions: Polymorphisms rs8192284 for IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN were associated with the susceptibility to suffer dengue fever in the sampled Colombian population. Resumen Introducción. La genética del huésped se reconoce como un factor que influye en el desarrollo del dengue. Objetivo. Este estudio evaluó la asociación del dengue con los polimorfismos rs8192284 del gen IL6R, rs3775290 del TLR3 y rs7248637 del DC-SIGN. Materiales y métodos. De los 292 sujetos encuestados, en 191 se confirmó la presencia de fiebre por dengue y los restantes 101 se incluyeron como controles. Los genotipos se resolvieron mediante reacción en cadena de la polimerasa y polimorfismos en la longitud de los fragmentos de restricción (PCR-RFLP). En un intento por determinar el riesgo de sufrir dengue, los datos se analizaron mediante la prueba de ji al cuadrado para los alelos y la regresión logística para los genotipos y las combinaciones alélicas. Los intervalos de confianza se calcularon a 95 % para todas las pruebas independientemente ajustadas por autoidentificación o componente genético ancestral. Resultados. En los afrocolombianos, el alelo C rs8192284 ofreció protección contra el dengue (OR=0,425; 0,204-0,887, p=0,020). Los alelos A rs7248637 y Ars3775290 plantearon un mayor riesgo de dengue para los afrocolombianos (OR=2,389; 1,170- 4,879; p=0,015) y los mestizos (OR=2,329; 1,283-4,226: p=0,005), respectivamente. La reproducibilidad para rs8192284 C/C (OR=2,45; 1,05-5,76; p=0,013) permaneció después del ajuste por el componente genético ancestral amerindio (OR=2,52; 1,04- 6,09; p=0,013). La reproducibilidad del rs3775290 A/A (OR=2,48; 1,09-5,65; p=0,033) permaneció después del ajuste por el componente europeo (OR=2,34; 1,02-5,35; p=0,048), el amerindio (OR=2,49; 1,09- 5,66; p=0,035), y el africano (OR=2,37; 1,04- 5,41; p=0,046). Por último, la asociación del dengue con la combinación alélica CAG (OR=2,07; 1,06-4,05; p=0,033) permaneció después del ajuste por el componente genético amerindio (OR=2,16; 1,09-4,28;p=0,028). Conclusión. Los polimorfismos rs8192284 en IL6R, rs3775290 en TLR3 y rs7248637 en DC-SIGN, se asociaron con la propensión a sufrir dengue en una muestra de población colombiana.
- Published
- 2019
18. Phylogenetics of South American Biomphalaria and description of a new species (Gastropoda: Planorbidae)
- Author
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Estrada, Victoria E., Velásquez, Luz E., Caldeira, Roberta L., Bejarano, Eduar E., Rojas, Winston, and Carvalho, Omar S.
- Published
- 2006
19. Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population
- Author
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Avendaño-Tamayo, Efren, Rúa, Alex, Parra-Marín, María Victoria, Rojas, Winston, Campo, Omer, Chacón-Duque, Juan, Agudelo-Flórez, Piedad, Narváez, Carlos F., Salgado, Doris M., Restrepo, Bertha Nelly, Bedoya, Gabriel, Avendaño-Tamayo, Efren, Rúa, Alex, Parra-Marín, María Victoria, Rojas, Winston, Campo, Omer, Chacón-Duque, Juan, Agudelo-Flórez, Piedad, Narváez, Carlos F., Salgado, Doris M., Restrepo, Bertha Nelly, and Bedoya, Gabriel
- Abstract
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease.Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN.Materials and methods: Of the 292 surveyed subjects, 191 were confirmed for dengue fever and the remaining 101 were included as controls. The genotypes were resolved using polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP). In an attempt to determine the risk (Odds Ratio) of suffering dengue fever, data were analyzed using chi-square for alleles and logistic regression for both genotypes and allelic combinations. Confidence intervals were set to 95% for all tests regardless of the adjustment by either self-identification or ancestry.Results: For Afro-Colombians, the allele rs8192284 C offered protection against dengue [OR=0.425,(0.204-0.887), p=0.020]. The alleles rs7248637 A and rs3775290 A posed, respectively, an increased risk of dengue for Afro-Colombians [OR=2.389, (1.170-4.879), p=0.015] and Mestizos [OR=2.329, (1.283-4.226), p=0.005]. The reproducibility for rs8192284 C/C [OR=2.45, (1.05-5.76), p=0.013] remained after adjustment by Amerindian ancestry [OR=2.52, (1.04-6.09), p=0.013]. The reproducibility for rs3775290 A/A [OR=2.48, (1.09-5.65), p=0.033] remained after adjustment by European [OR=2.34, (1.02-5.35), p=0.048], Amerindian [OR=2.49, (1.09-5.66), p=0.035], and African ancestry [OR=2.37, (1.04-5.41), p=0.046]. Finally, the association of dengue fever with the allelic combination CAG [OR=2.07, (1.06-4.05), p=0.033] remained after adjustment by Amerindian ancestry [OR=2.16, (1.09-4.28), p=0.028].Conclusions: Polymorphisms rs8192284 for IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN were associated with the susceptibility to suffer dengue fever in the sampled Colombian population., Introducción. La genética del huésped se reconoce como un factor que influye en el desarrollo del dengue.Objetivo. Este estudio evaluó la asociación del dengue con los polimorfismos rs8192284 del gen IL6R, rs3775290 del TLR3 y rs7248637 del DC-SIGN.Materiales y métodos. De los 292 sujetos encuestados, en 191 se confirmó la presencia de fiebre por dengue y los restantes 101 se incluyeron como controles. Los genotipos se resolvieron mediante reacción en cadena de la polimerasa y polimorfismos en la longitud de los fragmentos de restricción (PCR-RFLP). En un intento por determinar el riesgo de sufrir dengue, los datos se analizaron mediante la prueba de ji al cuadrado para los alelos y la regresión logística para los genotipos y las combinaciones alélicas. Los intervalos de confianza se calcularon a 95 % para todas las pruebas independientemente ajustadas por autoidentificación o componente genético ancestral.Resultados. En los afrocolombianos, el alelo C rs8192284 ofreció protección contra el dengue (OR=0,425; 0,204-0,887, p=0,020). Los alelos A rs7248637 y A rs3775290 plantearon un mayor riesgo de dengue para los afrocolombianos (OR=2,389; 1,170-4,879; p=0,015) y los mestizos (OR=2,329; 1,283-4,226: p=0,005), respectivamente. La reproducibilidad para rs8192284 C/C (OR=2,45; 1,05-5,76; p=0,013) permaneció después del ajuste por el componente genético ancestral amerindio (OR=2,52; 1,04-6,09; p=0,013). La reproducibilidad del rs3775290 A/A (OR=2,48; 1,09-5,65; p=0,033) permaneció después del ajuste por el componente europeo (OR=2,34; 1,02-5,35; p=0,048), el amerindio (OR=2,49; 1,09- 5,66; p=0,035), y el africano (OR=2,37; 1,04-5,41; p=0,046). Por último, la asociación del dengue con la combinación alélica CAG (OR=2,07; 1,06-4,05; p=0,033) permaneció después del ajuste por el componente genético amerindio (OR=2,16; 1,09-4,28; p=0,028).Conclusión. Los polimorfismos rs8192284 en IL6R, rs3775290 en TLR3 y rs7248637 en DC-SIGN, se asociaron con la propensión a sufrir dengue
- Published
- 2019
20. Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry
- Author
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Guzmán-Castañeda, Sandra J., primary, Ortega-Vega, Esteban L., additional, de la Cuesta-Zuluaga, Jacobo, additional, Velásquez-Mejía, Eliana P., additional, Rojas, Winston, additional, Bedoya, Gabriel, additional, and Escobar, Juan S., additional
- Published
- 2019
- Full Text
- View/download PDF
21. Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population
- Author
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Avendaño-Tamayo, Efren, primary, Rúa, Alex, primary, Parra-Marín, María Victoria, primary, Rojas, Winston, primary, Campo, Omer, primary, Chacón-Duque, Juan, primary, Agudelo-Flórez, Piedad, primary, Narváez, Carlos F., primary, Salgado, Doris M., primary, Restrepo, Bertha Nelly, primary, and Bedoya, Gabriel, primary
- Published
- 2019
- Full Text
- View/download PDF
22. Variantes en los genes TNFA , IL6 e IFNG asociadas con la gravedad del dengue en una muestra de población colombiana
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Avendaño-Tamayo, Efrén, Campo1, Omer, Chacón-Duque, Juan Camilo, Ramírez, Ruth, Rojas, Winston, Agudelo-Flórez, Piedad, Bedoya, Gabriel, and Restrepo, Berta Nelly
- Subjects
dengue/genética ,citocina ,genotype ,polymerase chain reaction ,polymorphism, genetic ,polimorfismo (genética) ,genotipo ,Colombia ,reacción en cadena de la polimerasa ,Dengue/genetics ,cytokines - Abstract
Resumen Introducción. La composición genética del huésped determina, entre otros aspectos, el perfil clínico del dengue, lo cual se debería al efecto de variantes en los genes que codifican citocinas proinflamatorias. Objetivo. Evaluar la asociación entre las variantes de tres polimorfismos en los genes candidatos TNFA, IL6 e IFNG con la gravedad del dengue en una población colombiana. Materiales y métodos. Se evaluaron los polimorfismos rs1800750, rs2069843 y rs2069705 de los genes TNFA, IL6 e IFNG, respectivamente, en 226 pacientes con dengue. Los genotipos se tipificaron usando la reacción en cadena de la polimerasa (PCR) y los polimorfismos de la longitud de los fragmentos de restricción (Restriction Fragment Length Polymorphism, RFLP). Para determinar el riesgo de diferentes fenotipos del dengue, se compararon las frecuencias alélicas con la prueba de ji al cuadrado, y los genotipos y los haplotipos, con regresión logística. Por último, los análisis se ajustaron utilizando datos de autoidentificación o del componente genético ancestral. Resultados. El alelo A del rs2069843, ajustado por autoidentificación, se asoció con casos de dengue hemorrágico en afrocolombianos. En la muestra completa, dicho polimorfismo, ajustado por componente genético ancestral, fue reproducible. Además, hubo asociaciones significativas entre las combinaciones alélicas GGT y GAC de los rs1800750, rs2069843 y rs2069705 en pacientes con dengue hemorrágico, con ajuste por componente genético ancestral y sin él. Además, la combinación alélica AGC produjo 58,03 pg/ml más de interleucina 6 que la GGC, independientemente de los componentes genéticos europeo, amerindio y africano. Conclusión. Las variantes de los polimorfismos GGT y GAC de los rs1800750, rs2069843 y rs2069705 en los genes TNFA, IL6 e IFNG, respectivamente, se correlacionaron con la gravedad del dengue en esta muestra de población colombiana. Abstract Introduction: The genetic makeup of the host contributes to the clinical profile of dengue. This could be due to the effect of variants in the genes encoding pro-inflammatory cytokines. Objective: To evaluate the association between the variants of three polymorphisms in TNFA, IL6 and IFNG candidate genes with dengue severity in a sample of Colombian population. Materials and methods: We evaluated the rs1800750, rs2069843, and rs2069705 polymorphisms in TNFA, IL6 and IFNG candidate genes, respectively, in 226 patients with dengue infection. The genotypes were typed using both polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). To determine the risk of different dengue phenotypes, we compared allele frequencies with chisquare and genotypes and haplotypes using logistic regression. Finally, these analyzes were adjusted with data from self-identification or the ancestral genetic component. Results: The A allele in the rs2069843 polymorphism, adjusted by self-identification, was associated with dengue hemorrhagic fever cases in Afro-Colombians. In the entire sample, this polymorphism, adjusted by the ancestral genetic component, was reproducible. In addition, there were significant associations between GGT and GAC allelic combinations of rs1800750, rs2069843, and rs2069705 in dengue hemorrhagic fever patients, with and without adjustment by ancestral genetic component. Additionally, the AGC allelic combination produced 58.03 pg/ml of interleukin-6 more than the GGC combination, regardless of European, Amerindian and African genetic components. Conclusions: The variants of GGT and GAC polymorphisms of rs1800750, rs2069843, and rs2069705 in the TNFA, IL6 and IFNG genes, respectively, were correlated with the susceptibility to dengue severity in a sample of Colombian population.
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- 2017
23. Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry.
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Guzmán-Castañeda, Sandra J., Ortega-Vega, Esteban L., de la Cuesta-Zuluaga, Jacobo, Velásquez-Mejía, Eliana P., Rojas, Winston, Bedoya, Gabriel, and Escobar, Juan S.
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- 2020
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24. Variantes genéticas de susceptibilidad en epilepsia genética generalizada en familias colombianas
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Tejada Moreno, Johanna, primary, Carrizosa Moog, Jaime, additional, Gomez Castillo, Christhian, additional, Medina Malo, Carlos, additional, Uscategui, Angelica, additional, Guio, Laura, additional, Cabrera Hemer, Dagoberto, additional, Rojas, Winston, additional, Cornejo Ochoa, William, additional, and Pineda Trujillo, Nicolás, additional
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- 2018
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25. Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry
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Guzmán-Castañeda, Sandra J., primary, Ortega-Vega, Esteban L., additional, Cuesta-Zuluaga, Jacobo de la, additional, Velásquez-Mejía, Eliana P., additional, Rojas, Winston, additional, Bedoya, Gabriel, additional, and Escobar, Juan S., additional
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- 2018
- Full Text
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26. Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population
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Avendaño-Tamayo, Efren, primary, Campo, Omer, additional, Chacón-Duque, Juan Camilo, additional, Ramírez, Ruth, additional, Rojas, Winston, additional, Agudelo-Flórez, Piedad, additional, Bedoya, Gabriel, additional, and Restrepo, Berta Nelly, additional
- Published
- 2017
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27. Genome-wide Ancestry and Demographic History of African-Descendant Maroon Communities from French Guiana and Suriname
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Fortes-Lima, Cesar, primary, Gessain, Antoine, additional, Ruiz-Linares, Andres, additional, Bortolini, Maria-Cátira, additional, Migot-Nabias, Florence, additional, Bellis, Gil, additional, Moreno-Mayar, J. Víctor, additional, Restrepo, Berta Nelly, additional, Rojas, Winston, additional, Avendaño-Tamayo, Efren, additional, Bedoya, Gabriel, additional, Orlando, Ludovic, additional, Salas, Antonio, additional, Helgason, Agnar, additional, Gilbert, M. Thomas P., additional, Sikora, Martin, additional, Schroeder, Hannes, additional, and Dugoujon, Jean-Michel, additional
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- 2017
- Full Text
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28. Genome-wide ancestry and demographic history of African-descendant Maroon communities from French Guiana and Suriname
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Fortes-Lima, Cesar, Gessain, Antoine, Ruiz-Linares, Andres, Bortolini, Maria-Cátira, Migot-Nabias, Florence, Bellis, Gil, Moreno Mayar, José Victor, Restrepo, Berta Nelly, Rojas, Winston, Avendaño-Tamayo, Efren, Bedoya, Gabriel, Orlando, Ludovic Antoine Alexandre, Salas, Antonio, Helgason, Agnar, Gilbert, Tom, Sikora, Martin, Schroeder, Hannes, Dugoujon, Jean-Michel, Fortes-Lima, Cesar, Gessain, Antoine, Ruiz-Linares, Andres, Bortolini, Maria-Cátira, Migot-Nabias, Florence, Bellis, Gil, Moreno Mayar, José Victor, Restrepo, Berta Nelly, Rojas, Winston, Avendaño-Tamayo, Efren, Bedoya, Gabriel, Orlando, Ludovic Antoine Alexandre, Salas, Antonio, Helgason, Agnar, Gilbert, Tom, Sikora, Martin, Schroeder, Hannes, and Dugoujon, Jean-Michel
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- 2017
29. Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population
- Author
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Avendaño-Tamayo, Efren, Campo, Omer, Chacón-Duque, Juan Camilo, Ramírez, Ruth, Rojas, Winston, Agudelo-Flórez, Piedad, Bedoya, Gabriel, Restrepo, Berta Nelly, Avendaño-Tamayo, Efren, Campo, Omer, Chacón-Duque, Juan Camilo, Ramírez, Ruth, Rojas, Winston, Agudelo-Flórez, Piedad, Bedoya, Gabriel, and Restrepo, Berta Nelly
- Abstract
Introduction: The genetic makeup of the host contributes to the clinical profile of dengue. This could be due to the effect of variants in the genes encoding pro-inflammatory cytokines.Objective: To evaluate the association between the variants of three polymorphisms in TNFA, IL6 and IFNG candidate genes with dengue severity in a sample of Colombian population.Materials and methods: We evaluated the rs1800750, rs2069843, and rs2069705 polymorphisms in TNFA, IL6 and IFNG candidate genes, respectively, in 226 patients with dengue infection. The genotypes were typed using both polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). To determine the risk of different dengue phenotypes, we compared allele frequencies with chi-square and genotypes and haplotypes using logistic regression. Finally, these analyzes were adjusted with data from self-identification or the ancestral genetic component.Results: The A allele in the rs2069843 polymorphism, adjusted by self-identification, was associated with dengue hemorrhagic fever cases in Afro-Colombians. In the entire sample, this polymorphism, adjusted by the ancestral genetic component, was reproducible. In addition, there were significant associations between GGT and GAC allelic combinations of rs1800750, rs2069843, and rs2069705 in dengue hemorrhagic fever patients, with and without adjustment by ancestral genetic component. Additionally, the AGC allelic combination produced 58.03 pg/ml of interleukin-6 more than the GGC combination, regardless of European, Amerindian and African genetic components.Conclusions: The variants of GGT and GAC polymorphisms of rs1800750, rs2069843, and rs2069705 in the TNFA, IL6 and IFNG genes, respectively, were correlated with the susceptibility to dengue severity in a sample of Colombian population., Introducción. La composición genética del huésped determina, entre otros aspectos, el perfil clínico del dengue, lo cual se debería al efecto de variantes en los genes que codifican citocinas proinflamatorias.Objetivo. Evaluar la asociación entre las variantes de tres polimorfismos en los genes candidatos TNFA, IL6 e IFNG con la gravedad del dengue en una población colombiana.Materiales y métodos. Se evaluaron los polimorfismos rs1800750, rs2069843 y rs2069705 de los genes TNFA, IL6 e IFNG, respectivamente, en 226 pacientes con dengue. Los genotipos se tipificaron usando la reacción en cadena de la polimerasa (PCR) y los polimorfismos de la longitud de los fragmentos de restricción (Restriction Fragment Length Polymorphism, RFLP). Para determinar el riesgo de diferentes fenotipos del dengue, se compararon las frecuencias alélicas con la prueba de ji al cuadrado, y los genotipos y los haplotipos, con regresión logística. Por último, los análisis se ajustaron utilizando datos de autoidentificación o del componente genético ancestral.Resultados. El alelo A del rs2069843, ajustado por autoidentificación, se asoció con casos de dengue hemorrágico en afrocolombianos. En la muestra completa, dicho polimorfismo, ajustado por componente genético ancestral, fue reproducible. Además, hubo asociaciones significativas entre las combinaciones alélicas GGT y GAC de los rs1800750, rs2069843 y rs2069705 en pacientes con dengue hemorrágico, con ajuste por componente genético ancestral y sin él. Además, la combinación alélica AGC produjo 58,03 pg/ml más de interleucina 6 que la GGC, independientemente de los componentes genéticos europeo, amerindio y africano.Conclusión. Las variantes de los polimorfismos GGT y GAC de los rs1800750, rs2069843 y rs2069705 en los genes TNFA, IL6 e IFNG, respectivamente, se correlacionaron con la gravedad del dengue en esta muestra de población colombiana.
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- 2017
30. Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra
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Cardona-Castro, Nora, Sánchez-Jiménez, Miryam, Rojas, Winston, and Bedoya-Berrío, Gabriel
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regiones promotoras genéticas ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,interleukin-10, cytokines ,interleukin-10 ,lcsh:R ,polymorphism, single nucleotide ,lcsh:Medicine ,interleucina-10, citocinas ,polimorfismo de nucleótido simple ,cytokines ,promoter regions, genetic ,lepra ,Leprosy - Abstract
Introduction. Polymorphisms in promoters of genes code for cytokines that affect transcription levels. Several have been associated with leprosy patients that have functional and clinical implications. Objective. Polymorphisms in the promoter of the IL10 gene of leprosy patients will be compared frequencies in normal population. Materials and methods. SNPs (single nucleotide polymorphism) -1082 A/G (rs1800896), -819C/T (rs1800871), and -592A/C (rs1800872) were identified in 100 leprosy patients and in a control group of 100 volunteers from a leprosy endemic region of Colombia. Results. The genotypes C/C and C/T in the SNP -819 were associated together with leprosy (OR=4.34, p
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- 2012
31. Cambios genéticos temporales y microgeográficos de Aedes aegypti en Medellín, Colombia
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Cadavid, Jorge Mario, Rúa, Guillermo, Campo, Omer, Bedoya, Gabriel, and Rojas, Winston
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haplotypes ,Aedes aegypti ,genoma mitocondrial ,Colombia ,haplotipos ,mitochondrial ,genome - Abstract
Introducción. Las poblaciones de Aedes aegypti pueden experimentar cambios en cuanto a su abundancia y diversidad genética y, con ello, su potencial evolutivo para responder al control vectorial. El conocimiento de los cambios en la variación genética a escala espacio-temporal, permite entender mejor la epidemiología del dengue y contribuye al diseño adecuado y oportuno de estrategias antivectoriales. Objetivo. Evaluar los cambios genéticos, la diversidad y el flujo génico en seis poblaciones microgeográficas de Ae. aegypti en Medellín en diferentes períodos epidemiológicos del dengue. Materiales y métodos. En 255 especímenes provenientes de seis barrios de Medellín, se evaluó la variación en la composición de los haplotipos mtDNA CO1 , así como la diversidad y la diferenciación genética en un período epidémico (2010) y en otro endémico (2012). Resultados. Se detectaron dos grupos de haplotipos muy diferenciados entre sí en ambos períodos, al igual que un haplotipo de alta frecuencia presente en todos los barrios. La mayor diversidad de haplotipos se registró en el 2012, pero la mayor diversidad de nucleótidos se presentó en el 2010. No se observó correlación significativa entre las distancias genéticas y geográficas. Conclusión. La composición genética de Ae. aegypti varía temporalmente sin un patrón predecible. La presencia de un haplotipo de gran frecuencia en ambos períodos podría ser indicio de una variación persistente adaptada al control vectorial. Sin embargo, la circulación simultánea de haplotipos CO1 muy diferenciados y compatibles con múltiples introducciones, sugiere que diversos acervos genéticos serían aptos para la transmisión. Estos resultados son compatibles con la dispersión del mosquito por efecto de actividades antrópicas, lo cual posibilitaría la diseminación rápida del virus durante epidemias en Medellín. Introduction: Aedes aegypti populations may experience changes in abundance and genetic diversity in addition to changes in their evolutionary capability to respond to vector control. The knowledge on the changes in genetic variation on a spatio-temporal scale improves the epidemiological understanding of dengue and supports the appropriate and timely design of vector control strategies. Objective: To assess the genetic changes, diversity and gene flow in six microgeographical populations of Ae. aegypti in Medellín for different epidemiological periods of dengue. Materials and methods: A total of 255 specimens from six different neighborhoods in Medellín were used to assess variations in the CO1 mtDNA haplotype composition, diversity and genetic differentiation for an epidemic period (2010) and an endemic period (2012). Results: Two groups of highly differentiated haplotypes were present in both periods, and a high-frequency haplotype was assessed for all neighborhoods. The highest haplotype diversity was recorded in 2012, but the maximum nucleotide diversity was recorded in 2010. No significant correlation between genetic and geographic distances was observed. Conclusions: The genetic composition of Ae. aegypti varies over time without a predictable pattern. In addition, the presence of a high-frequency haplotype in both periods could indicate a persistent variation adapted to vector control. However, the simultaneous movement of highly differentiated CO1 haplotypes compatible with multiple introductions suggests that different gene pools would be suitable for transmission. These results are consistent with mosquito dispersion due to human activities, which would enable the rapid spread of the virus during epidemics in Medellin.
- Published
- 2015
32. Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population.
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Avendaño-Tamayo, Efrén, Rúa, Alex, Parra-Marín, María Victoria, Rojas, Winston, Campo, Omer, Chacón-Duque, Juan, Agudelo-Flórez, Piedad, Narváez, Carlos F., Salgado, Doris M., Restrepo, Bertha Nelly, and Bedoya, Gabriel
- Subjects
DENGUE hemorrhagic fever ,DENGUE ,RESTRICTION fragment length polymorphisms ,POLYMERASE chain reaction - Abstract
Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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33. Multilocus analysis indicates that Trypanosoma cruzi I genetic substructure associated with sylvatic and domestic cycles is not an attribute conserved throughout Colombia
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Gómez-Palacio, Andrés, primary, Lopera, Juan, additional, Rojas, Winston, additional, Bedoya, Gabriel, additional, Cantillo-Barraza, Omar, additional, Marín-Suarez, Johana, additional, Triana-Chávez, Omar, additional, and Mejía-Jaramillo, Ana, additional
- Published
- 2016
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34. Microgeographic and temporal genetic changes of Aedes aegypti from Medellín, Colombia
- Author
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Cadavid, Jorge Mario, Rúa, Guillermo, Campo, Omer, Bedoya, Gabriel, Rojas, Winston, Cadavid, Jorge Mario, Rúa, Guillermo, Campo, Omer, Bedoya, Gabriel, and Rojas, Winston
- Abstract
Introduction: Aedes aegypti populations may experience changes in abundance and genetic diversity in addition to changes in their evolutionary capability to respond to vector control. The knowledge on the changes in genetic variation on a spatio-temporal scale improves the epidemiological understanding of dengue and supports the appropriate and timely design of vector control strategies.Objective: To assess the genetic changes, diversity and gene flow in six microgeographical populations of Ae. aegypti in Medellín for different epidemiological periods of dengue.Materials and methods: A total of 255 specimens from six different neighborhoods in Medellín were used to assess variations in the CO1 mtDNA haplotype composition, diversity and genetic differentiation for an epidemic period (2010) and an endemic period (2012).Results: Two groups of highly differentiated haplotypes were present in both periods, and a high-frequency haplotype was assessed for all neighborhoods. The highest haplotype diversity was recorded in 2012, but the maximum nucleotide diversity was recorded in 2010. No significant correlation between genetic and geographic distances was observed.Conclusions: The genetic composition of Ae. aegypti varies over time without a predictable pattern. In addition, the presence of a high-frequency haplotype in both periods could indicate a persistent variation adapted to vector control. However, the simultaneous movement of highly differentiated CO1 haplotypes compatible with multiple introductions suggests that different gene pools would be suitable for transmission. These results are consistent with mosquito dispersion due to human activities, which would enable the rapid spread of the virus during epidemics in Medellin., Introducción. Las poblaciones de Aedes aegypti pueden experimentar cambios en cuanto a su abundancia y diversidad genética y, con ello, su potencial evolutivo para responder al control vectorial. El conocimiento de los cambios en la variación genética a escala espacio-temporal, permite entender mejor la epidemiología del dengue y contribuye al diseño adecuado y oportuno de estrategias antivectoriales.Objetivo. Evaluar los cambios genéticos, la diversidad y el flujo génico en seis poblaciones microgeográficas de Ae. aegypti en Medellín en diferentes períodos epidemiológicos del dengue.Materiales y métodos. En 255 especímenes provenientes de seis barrios de Medellín, se evaluó la variación en la composición de los haplotipos mtDNA CO1, así como la diversidad y la diferenciación genética en un período epidémico (2010) y en otro endémico (2012).Resultados. Se detectaron dos grupos de haplotipos muy diferenciados entre sí en ambos períodos, al igual que un haplotipo de alta frecuencia presente en todos los barrios. La mayor diversidad de haplotipos se registró en el 2012, pero la mayor diversidad de nucleótidos se presentó en el 2010. No se observó correlación significativa entre las distancias genéticas y geográficas.Conclusión. La composición genética de Ae. aegypti varía temporalmente sin un patrón predecible. La presencia de un haplotipo de gran frecuencia en ambos períodos podría ser indicio de una variación persistente adaptada al control vectorial. Sin embargo, la circulación simultánea de haplotipos CO1 muy diferenciados y compatibles con múltiples introducciones, sugiere que diversos acervos genéticos serían aptos para la transmisión. Estos resultados son compatibles con la dispersión del mosquito por efecto de actividades antrópicas, lo cual posibilitaría la diseminación rápida del virus durante epidemias en Medellín.
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- 2015
35. CIRCULATION OVER THE CONTINENTAL SHELF OFF CENTRAL CHILE
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Pizarro, Oscar, Ramirez, Nadin, Rojas, Winston, and Castillo, Manuel
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- 2013
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36. COANCESTRÍA DE APELLIDOS Y LINAJES DEL CROMOSOMA Y EN EL NOROESTE DE COLOMBIA: UNA HERRAMIENTA ÚTIL PARA ESTABLECER MIGRACIÓN ENTRE POBLACIONES
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ROJAS, WINSTON, CAMPO, OMER, GARCÍA, JENNY, SOTO, IVÁN, DUQUE, CONSTANZA, BEDOYA, GABRIEL, and RUIZ-LINARES, ANDRÉS
- Subjects
Y chromosome ,surnames ,apellidos ,paternidad ,cromosoma Y ,paternity - Abstract
Por medio del análisis de marcadores genéticos del cromosoma Y, se estudió la composición de los linajes y su distribución en los apellidos más comunes en una muestra de 471 hombres provenientes del municipio de Marinilla (Antioquia) y su zona de influencia y del municipio de Aranzazu (Caldas), y en un grupo de muestras de la población general de Medellín. Además de encontrar una tasa variable de coancestría entre apellidos y linajes del cromosoma Y, también se detectó una gran similitud en el patrón de distribución de haplogrupos/haplotipos/apellidos entre Marinilla y su zona de influencia y Aranzazu, hallazgo que refuerza la idea de la migración histórica entre estas dos regiones. Esta similitud indicaría además que en las dos poblaciones pueden circular variantes genéticas comunes vinculadas a enfermedades humanas. Using Y chromosome genetic markers we studied the lineage composition and distribution in the most common surnames in 471 males from the municipality of Marinilla and its zone of influence, the municipality of Aranzazu (department of Caldas) and a group of samples from the general population of Medellin (Antioquia). Despite a variable rate of coancestry between surnames and Y-chromosome markers, we found a high similarity in the pattern of distribution of haplogroups/haplotypes/ surnames between Marinilla and its zone of influence and Aranzazu, reinforcing the historical migration between these two regions. This similarity would indicate that in both populations may be circulating common genetic variants linked to human diseases.
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- 2012
37. COMPOSICIÓN GENÉTICA DE UNA POBLACIÓN DEL SUROCCIDENTE DE COLOMBIA
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CÓRDOBA, LILIANA, GARCÍA, JHARLEY JAIR, HOYOS, LUZ STELLA, DUQUE, CONSTANZA, ROJAS, WINSTON, CARVAJAL, SILVIO, ESCOBAR, LUISA F, REYES, INGRID, CAJAS, NOHELIA, SÁNCHEZ, ADALBERTO, GARCÍA, FELIPE, BEDOYA, GABRIEL, and RUIZ-LINARES, ANDRÉS
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mezcla ,variantes genéticas ,departamento del Cauca ,genetic markers ,admixture ,Province of Cauca - Abstract
La población actual del departamento del Cauca es el resultado de la mezcla de tres poblaciones parentales (europea, amerindia y africana). En este estudio se determinó la composición genética de 306 residentes del departamento mediante la utilización de 34 variantes autosómicas, 9 variantes en el cromosoma X, 6 en el ADNmt y 8 en el cromosoma Y. Los análisis de las variantes autosómicas y del cromosoma X revelaron que la población europea y la amerindia han contribuido en mayor proporción al actual acervo genético de la población estudiada. Los resultados de las variantes en el ADNmt y del cromosoma Y sugieren un fuerte sesgo sexual (flujo génico asimétrico) en el proceso de mezcla, en el que los cruces interétnicos fueron principalmente entre los colonizadores europeos y las mujeres nativas. The contemporary population of the Province of Cauca is the result of the admixture between three parental populations (European, Amerindian and African). Genetic composition was determined in 306 residents of the Province with the use of 34 autosomal markers, 9 markers in chromosome X, 6 and 8 mtDNA in chromosome Y. Autosomal and X chromosome data indicate that both European and Amerindian populations have contributed to a greater extent to the current genetic pool of the population. The mtDNA and the Y chromosome data, indicate a strong sexual bias (asymmetrical gene flow) in the admixing process, where interethnic crosses were mainly between European men and native women.
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- 2012
38. Análisis de isonimia entre poblaciones del noroeste de Colombia
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Bedoya, Gabriel, García, Jenny, Montoya, Patricia, Rojas, Winston, Amézquita, Maria Eugenia, Soto, Iván, López, Maria Cecilia, Ospina-Duque, Jorge, and Ruiz-Linares, Andrés
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consanguinity ,founder effect ,nombres ,efecto fundador ,Names ,population ,genetics ,población ,consanguinidad ,genética ,Colombia - Abstract
Introducción. La utilización de la frecuencia de apellidos como marcadores de linajes paternos ha permitido caracterizar poblaciones. Los principios de isonimia se han empleado para determinar el grado de estructuración genética, las tasas de migraciones y las relaciones de ancestría y origen entre poblaciones. Este análisis se aplicó a dos poblaciones históricamente relacionadas y consideradas como aislados genéticos. Objetivo. Evaluar las relaciones genéticas y de origen entre Aranzazu y Marinilla y su zona de influencia por medio de análisis de frecuencia de apellidos. Materiales y métodos. A partir de la base de datos del Sistema de Identificación de Beneficiarios de los Programas Sociales, Sisbén, se calcularon los parámetros poblacionales de coeficiente de parentesco (fiii), la homogeneidad poblacional con los estimadores B (porcentaje de la población que comparte los siete apellidos más frecuentes) y C (15 apellidos más frecuentes) y la distancia genética de Cavalli-Sforza en tres poblaciones del núcleo fundador de Marinilla y Rionegro como población externa. Resultados. Marinilla y Aranzazu, al igual que las poblaciones de Marinilla y su zona de influencia, mostraron los mayores valores de homogeneidad (valores B entre 0,25 y 0,5) comparados con Rionegro (B = 0,159) y también mayores valores de parentesco intrapoblacional (valores fiii entre 0,0034 y 0,01). Las menores distancias se encontraron entre Marinilla y Aranzazu. Conclusiones. Aranzazu es una población con características similares a las de Marinilla y su zona de influencia y debido al efecto fundador, estas poblaciones pueden presentar características genéticas similares. Por lo tanto, las enfermedades genéticas, principalmente las de herencia compleja, podrían tener la misma etiología genética en ambas poblaciones, lo que garantizaría las condiciones óptimas para estudios de cartografía genética. Introduction. Surname frequency (isonymy) is used as a marker of paternal lineage and is used to characterize human population structure. Principles of isonymy were used to determine the genetic structure, migration rates, ancestry relations and origins of populations. This analysis was applied to two historically related local populations which currently are considered to be genetically isolated. Objective. The genetic relationships and influence zones of the Aranzazu and Marinilla populations were assessed by means of surname frequency analysis. Materials and methods. Data originated from database with the title "System of Identification of Beneficiaries of the Social Programs" database or Sisben. Population parameters such as a priori kinship (phiii), population homogeneity with B and C estimators, and Cavalli-Sforza’s genetic distance were calculated for (a) three towns of Marinilla and its influence zone and (b) Aranzazu. The Rionegro population served as an external, comparison population. Results. The Aranzazu and Marinilla populations showed the higher homogeneity (B value between 0.25 and 0.5) in contrast with Rionegro (B = 0.159), as well as greater a priori kinship values (phiii between 0.003 and 0.010). The lowest distances were found between Marinilla and Aranzazu. Conclusions. Aranzazu is a population with characteristics similar to those of Marinilla and its influence zone. The close similarity of genetic characteristics for these populations is due probably to a founder effect. Furthermore, the genetic similarity predicts that genetic diseases will have the same etiology in both populations and provides optimum conditions for gene mapping studies.
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- 2006
39. DATA REPORT: MEDICIONES OCEANOGRÁFICAS EN LAS BAHÍAS CONCEPCIÓN Y SAN VICENTE (Verano 2004-2005)
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Pizarro, Oscar, Ramos, Marcel, Hormazabal, Cesar, Rojas, Winston, Montecinos, Aldo, Hormazabal, Samuel, and Navarro, Eduardo
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- 2005
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40. DataReport CTD CAMPAÑA DE VERANO, Proyecto de Modelación Hidrológica y Control de la Contaminación en las Bahías de Concepción y San Vicente
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Rojas, Winston, Pizarro, Oscar, and Ramos, Marcel
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- 2005
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41. Cambios genéticos temporales y micro geográficos de Aedes aegypti de Medellín, Colombia
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Cadavid, Jorge Mario, primary, Rúa, Guillermo, additional, Campo, Omer, additional, Bedoya, Gabriel, additional, and Rojas, Winston, additional
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- 2014
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42. African genetic ancestry is associated with a protective effect on Dengue severity in colombian populations
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Chacón-Duque, Juan Camilo, primary, Adhikari, Kaustubh, additional, Avendaño, Efren, additional, Campo, Omer, additional, Ramirez, Ruth, additional, Rojas, Winston, additional, Ruiz-Linares, Andrés, additional, Restrepo, Berta Nelly, additional, and Bedoya, Gabriel, additional
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- 2014
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43. Distribution ofAPOEpolymorphism in the “Paisa” population from northwest Colombia (Antioquia)
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Velez-Pardo, Carlos, primary, Rojas, Winston, additional, Jimenez-Del-Rio, Marlene, additional, and Bedoya, Gabriel, additional
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- 2014
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44. Evaluating the X Chromosome-Specific Diversity of Colombian Populations Using Insertion/Deletion Polymorphisms
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Ibarra, Adriana, primary, Restrepo, Tomás, additional, Rojas, Winston, additional, Castillo, Adriana, additional, Amorim, António, additional, Martínez, Beatriz, additional, Burgos, German, additional, Ostos, Henry, additional, Álvarez, Karen, additional, Camacho, Mauricio, additional, Suarez, Zuleyma, additional, Pereira, Rui, additional, and Gusmão, Leonor, additional
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- 2014
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45. Influence ofCCR5andCCR2Genetic Variants in the Resistance/Susceptibility to HIV in Serodiscordant Couples from Colombia
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Zapata, Wildeman, primary, Aguilar-Jiménez, Wbeimar, additional, Pineda-Trujillo, Nicolás, additional, Rojas, Winston, additional, Estrada, Hernando, additional, and Rugeles, María T., additional
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- 2013
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46. IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample
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Cardona-Castro, Nora, Sánchez-Jiménez, Miryan, Rojas, Winston, Bedoya-Berrío, Gabriel, Cardona-Castro, Nora, Sánchez-Jiménez, Miryan, Rojas, Winston, and Bedoya-Berrío, Gabriel
- Abstract
Introduction. Polymorphisms in promoters of genes code for cytokines that affect transcription levels. Several have been associated with leprosy patients that have functional and clinical implications. Objective. Polymorphisms in the promoter of the IL10 gene of leprosy patients will be compared frequencies in normal population.Materials and methods. SNPs (single nucleotide polymorphism) -1082 A/G (rs1800896), -819C/T (rs1800871), and -592A/C (rs1800872) were identified in 100 leprosy patients and in a control group of 100 volunteers from a leprosy endemic region of Colombia.Results. The genotypes C/C and C/T in the SNP -819 were associated together with leprosy (OR=4.34, p<0.001). Similarly, the genotypes C/C and C/A in the -592 SNP showed an association (OR=4.3, p<0.001). The haplotypes -819C-519C and -1082A-819C-592C showed significant association (OR=4.34, p<0.001 and OR=6.25, p<0.001) respectively. These haplotypes in homozygosis conditions were also associated with leprosy: -819C-519C/-819C-519C (OR=4.34, p<0.001), -1082A -819C-592C/-1082A -819C-592C (OR=1.90, p=0.04). The SNP -1082 was not associated with leprosy in this population.Conclusions. The haplotypes associated with leprosy, -1082A-819C-592C/-1082A-819C-592C, have been reported as low producers of IL-10. Functionally, the low production of IL-10 may have immune response consequences and clinical implications. Additional haplotypes of IL-10 have been reported as markers for leprosy susceptibility or resistance in other ethnic populations. This suggests that differences in distribution of diverse IL-10 gene polymorphisms among ethnic groups may indicate important gene-disease associations., Introducción. Se han reportado polimorfismos en los genes promotores que codifican para citocinas y que afectan los niveles de transcripción, con implicaciones clínicas y funcionales en pacientes con lepra.Objetivo. Detectar los polimorfismos en el gen promotor de la interleucina 10 (IL-10), de los polimorfismos de un solo nucleótido (Single Nucleotide Polymorphisms, SNP) -1082 A/G (rs1800896), -819C/T (rs1800871) y -592A/C (rs1800872), en 100 pacientes con lepra y un grupo control de 100 voluntarios, de una región endémica de Colombia.Resultados. Los haplotipos -819C-519C y -1082A-819C-592C mostraron asociación significativa con lepra: OR=4,34, p=1 x 10-3, y OR=6,25, p=5 x 10-4, respectivamente. Estos haplotipos en condiciones de homocigoto, están también asociados con lepra: -819C-519C/-819C-519C (OR=4,34 p=1 x 10-3), -1082A -819C-592C/-1082A -819C-592C (OR=1,90 y p=0,04). El SNP -1082 no se encontró asociadocon lepra en esta población. Los genotipos C/C y C/T en el SNP -819, se encontraron asociados a lepra (OR=4,34, p=1 x 10-3); de igual manera, los genotipos C/C y C/A en el SNP -592 mostraron asociación (OR=4,34, p=1 x 10-3).Conclusiones. El haplotipo que encontramos asociado con lepra, -1082A-819C-592C/-1082A-819C-592C, se ha relacionado con baja producción de IL-10. Funcionalmente, esta baja producción de IL-10 puede tener consecuencias en la respuesta inmunitaria, además de implicaciones clínicas. Se han reportado diferentes haplotipos de IL-10 como marcadores de vulnerabilidad y resistencia de lepra en otras poblaciones, lo cual sugiere que las diferencias en la distribución de diversos polimorfismos del gen de IL-10 entre grupos étnicos, es un factor importante al determinar la asociación entre enfermedad y genes. DOI: http://dx.doi.org/10.7705/biomedica.v32i1.386
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- 2012
47. Características clínicas y niveles de citocinas en pacientes con dengue y su relación con la raza. Colombia
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Restrepo, Berta Nelly, Ramírez Salazar, Ruth Emilia, Agudelo Florez, Piedad, Avedaño, Efrén, Chacón, Juan Camilo, Rojas, Winston, Bedoya, Gabriel, Restrepo, Berta Nelly, Ramírez Salazar, Ruth Emilia, Agudelo Florez, Piedad, Avedaño, Efrén, Chacón, Juan Camilo, Rojas, Winston, and Bedoya, Gabriel
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- 2010
48. Analysis of polymorphisms in the trypanothione reductase and cruzipain genes in Colombian strains of Trypanosoma cruzi
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Rojas, Winston, Caro, Maria Antonieta, Lopera, Juan Guillermo, Triana, Omar, Dib, Juan Carlos, Bedoya, Gabriel, Rojas, Winston, Caro, Maria Antonieta, Lopera, Juan Guillermo, Triana, Omar, Dib, Juan Carlos, and Bedoya, Gabriel
- Abstract
Introduction. Genetic studies of Trypanosoma cruzi have tried to establish relations between genetic variants and their biological characteristics, such as clinical manifestations, host or geographic origin. However, much controversy exists on the associations between the commonly used DNA markers with group, clinical characteristics and disease epidemiology.Objective. In this study determined the variability of the genes that code for the proteins trypanothione reductase and cruzipain, both involved in the infection and survival of the parasite in the mammalian host, was studied and the association between genetic polymorphism and biological and geographic sources in Colombian T. cruzi strains was examined.Materials and methods. The genotypes for each of six SNPs (single nucleotide polymorphisms) for trypanothione reductase and eight SNPs for cruzipain genes were identified by polymerase chain reaction-restriction fragment length polymorphism.in 36 T. cruzi Colombian stocks from several regions and biological origins. Results. Three genotypes were identified for trypanothione reductase with Acy I and Hae III enzymes and six genotypes for cruzipain with the Rsa I, Ban I and Bsu 36I enzymes. Conclusion. For trypanothione reductase ,an association was not established with biological or geographical origin; however, alleles at positions 102 and 210 allowed discrimination with groups I and II. For cruzipain, specific genotypes were associated with group, biological and geographic origin. The usefulness of molecular markers on these genes was demonstrated for the determination and differentiation of genetic varieties in T. cruzi., Introducción. Los estudios genéticos en Trypanosoma cruzi han buscado establecer asociaciones de variantes genéticas del parásito con manifestaciones clínicas de la enfermedad, origen biológico y geográfico de los aislamientos; sin embargo, los resultados de asociación con los marcadores comúnmente usados en estos estudios han generado mucha controversia, principalmente en la asociación de grupos con características clínicas y epidemiológicas de la enfermedad.Objetivo. Se planteó determinar la variabilidad de genes que codifican para las proteínas tripanotión reductasa y cruzipaína, involucradas en mecanismos de infección y supervivencia del parásito en el hospedador mamífero, y probar la asociación de variantes génicas con origen biológico y geográfico de cepas colombianas de T. cruzi.Materiales y métodos. Se tipificaron por reacción en cadena de la polimerasa- polimorfismo de longitud del fragmento de restricción seis SNPs (Single Nucleotide Polymorphisms) en tripanotión reductasa y ocho SNPs en cruzipaína en 36 cepas colombianas de T. cruzi de diferentes regiones y origen biológico.Resultados. Con las enzimas Acy I y Hae III se determinaron tres genotipos para tripanotión reductasa. Para cruzipaína se identificaron seis genotipos con las enzimas Rsa I, Ban I y Bsu 36I.Conclusiones. Para tripanotión reductasa no fue posible establecer una asociación con el origen biológico o geográfico; sin embargo los alelos producidos en las posiciones 102 y 210, permitieron discriminar los grupos tradicionales I y II. Con los genotipos obtenidos para cruzipaína se establecieron relaciones a estos grupos, origen biológico y geográfico. Los resultados sugieren la utilidad de estos genes como marcadores moleculares para determinar y diferenciar variedades genéticas en T. cruzi.
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- 2007
49. Erratum: Corrigendum: Reconstructing Native American population history
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Reich, David, primary, Patterson, Nick, additional, Campbell, Desmond, additional, Tandon, Arti, additional, Mazieres, Stéphane, additional, Ray, Nicolas, additional, Parra, Maria V., additional, Rojas, Winston, additional, Duque, Constanza, additional, Mesa, Natalia, additional, García, Luis F., additional, Triana, Omar, additional, Blair, Silvia, additional, Maestre, Amanda, additional, Dib, Juan C., additional, Bravi, Claudio M., additional, Bailliet, Graciela, additional, Corach, Daniel, additional, Hünemeier, Tábita, additional, Bortolini, Maria Cátira, additional, Salzano, Francisco M., additional, Petzl-Erler, María Luiza, additional, Acuña-Alonzo, Victor, additional, Aguilar-Salinas, Carlos, additional, Canizales-Quinteros, Samuel, additional, Tusié-Luna, Teresa, additional, Riba, Laura, additional, Rodríguez-Cruz, Maricela, additional, Lopez-Alarcón, Mardia, additional, Coral-Vazquez, Ramón, additional, Canto-Cetina, Thelma, additional, Silva-Zolezzi, Irma, additional, Fernandez-Lopez, Juan Carlos, additional, Contreras, Alejandra V., additional, Jimenez-Sanchez, Gerardo, additional, Gómez-Vázquez, Maria José, additional, Molina, Julio, additional, Carracedo, Ángel, additional, Salas, Antonio, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, B.Witonsky, David, additional, Alkorta-Aranburu, Gorka, additional, Sukernik, Rem I., additional, Osipova, Ludmila, additional, Fedorova, Sardana A., additional, Vasquez, René, additional, Villena, Mercedes, additional, Moreau, Claudia, additional, Barrantes, Ramiro, additional, Pauls, David, additional, Excoffier, Laurent, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Dugoujon, Jean-Michel, additional, Larrouy, Georges, additional, Klitz, William, additional, Labuda, Damian, additional, Kidd, Judith, additional, Kidd, Kenneth, additional, Di Rienzo, Anna, additional, Freimer, Nelson B., additional, Price, Alkes L., additional, and Ruiz-Linares, Andrés, additional
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- 2012
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50. Isonymy analysis between 2 populations in northwestern Colombia
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Bedoya, Gabriel, García, Jenny, Montoya, Patricia, Rojas, Winston, Amézquita, Maria Eugenia, Soto, Iván, López, Maria Cecilia, Ospina-Duque, Jorge, Ruiz-Linares, Andrés, Bedoya, Gabriel, García, Jenny, Montoya, Patricia, Rojas, Winston, Amézquita, Maria Eugenia, Soto, Iván, López, Maria Cecilia, Ospina-Duque, Jorge, and Ruiz-Linares, Andrés
- Abstract
Introduction. Surname frequency (isonymy) is used as a marker of paternal lineage and is used to characterize human population structure. Principles of isonymy were used to determine the genetic structure, migration rates, ancestry relations and origins of populations. This analysis was applied to two historically related local populations which currently are considered to be genetically isolated.Objective. The genetic relationships and influence zones of the Aranzazu and Marinilla populations were assessed by means of surname frequency analysis.Materials and methods. Data originated from database with the title "System of Identification of Beneficiaries of the Social Programs" database or Sisben. Population parameters such as a priori kinship (fii), population homogeneity with B and C estimators, and Cavalli-Sforza's genetic distance were calculated for (a) three towns of Marinilla and its influence zone and (b) Aranzazu. The Rionegro population served as an external, comparison population.Results. The Aranzazu and Marinilla populations showed the higher homogeneity (B value between 0.25 and 0.5) in contrast with Rionegro (B = 0.159), as well as greater a priori kinship values (fii between 0.003 and 0.010). The lowest distances were found between Marinilla and Aranzazu.Conclusions. Aranzazu is a population with characteristics similar to those of Marinilla and its influence zone. The close similarity of genetic characteristics for these populations is due probably to a founder effect. Furthermore, the genetic similarity predicts that genetic diseases will have the same etiology in both populations and provides optimum conditions for gene mapping studies., Introducción. La utilización de la frecuencia de apellidos como marcadores de linajes paternos ha permitido caracterizar poblaciones. Los principios de isonimia se han empleado para determinar el grado de estructuración genética, las tasas de migraciones y las relaciones de ancestría y origen entre poblaciones. Este análisis se aplicó a dos poblaciones históricamente relacionadas y consideradas como aislados genéticos.Objetivo. Evaluar las relaciones genéticas y de origen entre Aranzazu y Marinilla y su zona de influencia por medio de análisis de frecuencia de apellidos.Materiales y métodos. A partir de la base de datos del Sistema de Identificación de Beneficiarios de los Programas Sociales, Sisbén, se calcularon los parámetros poblacionales de coeficiente de parentesco (fii), la homogeneidad poblacional con los estimadores B (porcentaje de la población que comparte los siete apellidos más frecuentes) y C (15 apellidos más frecuentes) y la distancia genética de Cavalli-Sforza en tres poblaciones del núcleo fundador de Marinilla y Rionegro como población externa.Resultados. Marinilla y Aranzazu, al igual que las poblaciones de Marinilla y su zona de influencia, mostraron los mayores valores de homogeneidad (valores B entre 0,25 y 0,5) comparados con Rionegro (B = 0,159) y también mayores valores de parentesco intrapoblacional (valores fii entre 0,0034 y 0,01). Las menores distancias se encontraron entre Marinilla y Aranzazu.Conclusiones. Aranzazu es una población con características similares a las de Marinilla y su zona de influencia y debido al efecto fundador, estas poblaciones pueden presentar características genéticas similares. Por lo tanto, las enfermedades genéticas, principalmentelas de herencia compleja, podrían tener la misma etiología genética en ambas poblaciones, lo que garantizaría las condiciones óptimas para estudios de cartografía genética.
- Published
- 2006
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