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Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra
- Source :
- Biomédica: revista del Instituto Nacional de Salud, Vol 32, Iss 1, Pp 71-76 (2012), Biomédica, Volume: 32, Issue: 1, Pages: 71-76, Published: MAR 2012
- Publication Year :
- 2012
- Publisher :
- Instituto Nacional de Salud, 2012.
-
Abstract
- Introduction. Polymorphisms in promoters of genes code for cytokines that affect transcription levels. Several have been associated with leprosy patients that have functional and clinical implications. Objective. Polymorphisms in the promoter of the IL10 gene of leprosy patients will be compared frequencies in normal population. Materials and methods. SNPs (single nucleotide polymorphism) -1082 A/G (rs1800896), -819C/T (rs1800871), and -592A/C (rs1800872) were identified in 100 leprosy patients and in a control group of 100 volunteers from a leprosy endemic region of Colombia. Results. The genotypes C/C and C/T in the SNP -819 were associated together with leprosy (OR=4.34, p
Details
- Language :
- English
- ISSN :
- 01204157
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biomédica: revista del Instituto Nacional de Salud
- Accession number :
- edsair.dedup.wf.001..794a174977697295afea92ce072b036e