1. Effect of Modified Hydroxypropyl Tapioca Starch and Percentage of Drug Loading on Physical Property of Paracetamol Tablet
- Author
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Chaisai Sirisapaya, Sontaya Limmatvapirat, Suchada Piriyaprasarth, Kulmanee Anantakul, Vipaluk Patomchaiviwat, and Rohanee Kolae
- Subjects
Tapioca starch ,food.ingredient ,Mechanical Engineering ,05 social sciences ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Modified starch ,Physical property ,chemistry.chemical_compound ,food ,Chemical engineering ,chemistry ,Mechanics of Materials ,0502 economics and business ,General Materials Science ,Pregelatinized starch ,0210 nano-technology ,Filler (animal food) ,050203 business & management - Abstract
The objective of this study was to investigate the effect of modified hydroxypropyl tapioca starch (HPTS) and % drug loading on physical property of tablet. Paracetamol was used as model drug because of its poor compressibility. The filler ability of modified HPTS such as hydroxyl propyl oxidized tapioca starch (HPOTS), hydroxyl propyl crosslinked tapioca starch (HPCTS) and pregelatinized tapioca starch (PTS) were evaluated and compared with the commercial starch (Starch 1500®). Tablets were prepared by direct compression method and the percent drug loading were 15, 30, 45, 60, 75%. For modified HPTS, the hardness of the tablets tended to decrease when the concentration of paracetamol increased. At drug concentrations of 15-30%, HPOTS exhibited good performance of tablet as indicated by the high hardness, low friability and acceptable disintegration time. The obtained results were better than HPTS and comparable to Starch 1500®. Moreover, the results revealed that tablet containing PTS provided the highest hardness and prolonged disintegration time (>30 min) while tablet containing HPCTS showed rapid disintegration time (
- Published
- 2020
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