82,995 results on '"Roe, A."'
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2. From Assessment to Practice: Implementing the AIAS Framework in EFL Teaching and Learning
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Roe, Jasper, Perkins, Mike, and Furze, Leon
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Computer Science - Computers and Society - Abstract
Recent advances in Generative AI (GenAI) are transforming multiple aspects of society, including education and foreign language learning. In the context of English as a Foreign Language (EFL), significant research has been conducted to investigate the applicability of GenAI as a learning aid and the potential negative impacts of new technologies. Critical questions remain about the future of AI, including whether improvements will continue at such a pace or stall and whether there is a true benefit to implementing GenAI in education, given the myriad costs and potential for negative impacts. Apart from the ethical conundrums that GenAI presents in EFL education, there is growing consensus that learners and teachers must develop AI literacy skills to enable them to use and critically evaluate the purposes and outputs of these technologies. However, there are few formalised frameworks available to support the integration and development of AI literacy skills for EFL learners. In this article, we demonstrate how the use of a general, all-purposes framework (the AI Assessment Scale) can be tailored to the EFL writing and translation context, drawing on existing empirical research validating the scale and adaptations to other contexts, such as English for Academic Purposes. We begin by engaging with the literature regarding GenAI and EFL writing and translation, prior to explicating the use of three levels of the updated AIAS for structuring EFL writing instruction which promotes academic literacy and transparency and provides a clear framework for students and teachers.
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- 2025
3. The AI Assessment Scale Revisited: A Framework for Educational Assessment
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Perkins, Mike, Roe, Jasper, and Furze, Leon
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Computer Science - Computers and Society - Abstract
Recent developments in Generative Artificial Intelligence (GenAI) have created significant uncertainty in education, particularly in terms of assessment practices. Against this backdrop, we present an updated version of the AI Assessment Scale (AIAS), a framework with two fundamental purposes: to facilitate open dialogue between educators and students about appropriate GenAI use and to support educators in redesigning assessments in an era of expanding AI capabilities. Grounded in social constructivist principles and designed with assessment validity in mind, the AIAS provides a structured yet flexible approach that can be adapted across different educational contexts. Building on implementation feedback from global adoption across both the K-12 and higher education contexts, this revision represents a significant change from the original AIAS. Among these changes is a new visual guide that moves beyond the original traffic light system and utilises a neutral colour palette that avoids implied hierarchies between the levels. The scale maintains five distinct levels of GenAI integration in assessment, from "No AI" to "AI Exploration", but has been refined to better reflect rapidly advancing technological capabilities and emerging pedagogical needs. This paper presents the theoretical foundations of the revised framework, provides detailed implementation guidance through practical vignettes, and discusses its limitations and future directions. As GenAI capabilities continue to expand, particularly in multimodal content generation, the AIAS offers a starting point for reimagining assessment design in an era of disruptive technologies.
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- 2024
4. Predicting Autism Traits from Baby Wellness Records: A Machine Learning Approach
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Ayelet Ben-Sasson, Joshua Guedalia, Keren Ilan, Meirav Shaham, Galit Shefer, Roe Cohen, Yuval Tamir, and Lidia V. Gabis
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Early detection of autism spectrum condition is crucial for children to maximally benefit from early intervention. The study examined a machine learning model predicting the increased likelihood for autism from wellness records from 0 to 24 months. The study included 591,989 non-autistic and 12,846 autistic children. A gradient boosting model with a threefold cross-validation and SHAPley additive explanation tool quantified feature importance. The model had an average area under the curve of 0.81 (SD = 0.004). The high-likelihood group detected by the model had a 0.073 autism spectrum condition incidence rate; 3.42-fold more than in the entire cohort (0.02). Sex-specific models had higher specificity (0.81 boys and 0.79 girls) than sensitivity (0.64 boys and 0.66 girls). The common predictors were more parental concerns, older mothers, never nursing, lower initial and higher last weight percentiles, and several delayed milestones. SHAPley additive explanation tool results show common, important predictors in the full sample and separate boys' and girls' models. These included birth, growth, familial, postnatal parameters and delayed language, fine motor, and social milestones from 12 to 24 months. Machine learning algorithms can help detect increased autism signs by relying on the multidimensional data routinely recorded during the first 2 years.
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- 2024
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5. Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis.
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Park, So, Ju, Sungeun, Lee, Jaehoon, Kim, Hwa-Ryeon, Sub, Yujin, Park, Dong, Park, Seyeon, Kwon, Doru, Kang, Hyeok, Shin, Ji, Kim, Dong, Paik, Ji, Cho, Seok, Shim, Hyeran, Kim, Young-Joon, Guan, Kun-Liang, Chun, Kyung-Hee, Choi, Junjeong, Ha, Sang-Jun, Gee, Heon, Roe, Jae-Seok, Lee, Han-Woong, Park, Seung-Yeol, and Park, Hyun
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Animals ,Golgi Apparatus ,Macrophages ,Inflammation ,Mice ,Transcriptional Coactivator with PDZ-Binding Motif Proteins ,Carcinogenesis ,YAP-Signaling Proteins ,Humans ,Adaptor Proteins ,Signal Transducing ,Signal Transduction ,Transcription Factors ,Chronic Disease ,Mice ,Knockout - Abstract
Until now, Hippo pathway-mediated nucleocytoplasmic translocation has been considered the primary mechanism by which yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) transcriptional coactivators regulate cell proliferation and differentiation via transcriptional enhanced associate domain (TEAD)-mediated target gene expression. In this study, however, we found that TAZ, but not YAP, is associated with the Golgi apparatus in macrophages activated via Toll-like receptor ligands during the resolution phase of inflammation. Golgi-associated TAZ enhanced vesicle trafficking and secretion of proinflammatory cytokines in M1 macrophage independent of the Hippo pathway. Depletion of TAZ in tumor-associated macrophages promoted tumor growth by suppressing the recruitment of tumor-infiltrating lymphocytes. Moreover, in a diet-induced metabolic dysfunction-associated steatohepatitis model, macrophage-specific deletion of TAZ ameliorated liver inflammation and hepatic fibrosis. Thus, targeted therapies being developed against YAP/TAZ-TEAD are ineffective in macrophages. Together, our results introduce Golgi-associated TAZ as a potential molecular target for therapeutic intervention to treat tumor progression and chronic inflammatory diseases.
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- 2025
6. Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life
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Roe, James M, Vidal-Piñeiro, Didac, Sørensen, Øystein, Grydeland, Håkon, Leonardsen, Esten H, Iakunchykova, Olena, Pan, Mengyu, Mowinckel, Athanasia, Strømstad, Marie, Nawijn, Laura, Milaneschi, Yuri, Andersson, Micael, Pudas, Sara, Bråthen, Anne Cecilie Sjøli, Kransberg, Jonas, Falch, Emilie Sogn, Øverbye, Knut, Kievit, Rogier A, Ebmeier, Klaus P, Lindenberger, Ulman, Ghisletta, Paolo, Demnitz, Naiara, Boraxbekk, Carl-Johan, Drevon, Christian A, Penninx, Brenda, Bertram, Lars, Nyberg, Lars, Walhovd, Kristine B, Fjell, Anders M, and Wang, Yunpeng
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Biological Psychology ,Biological Sciences ,Genetics ,Psychology ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Aging ,Brain Disorders ,Alzheimer's Disease ,Neurosciences ,Acquired Cognitive Impairment ,Neurodegenerative ,Prevention ,2.1 Biological and endogenous factors ,4.1 Discovery and preclinical testing of markers and technologies ,1.1 Normal biological development and functioning ,Neurological ,Mental health ,Humans ,Alzheimer Disease ,Aged ,Brain ,Male ,Female ,Middle Aged ,Aged ,80 and over ,Adult ,Memory Disorders ,Longitudinal Studies ,Genetic Variation ,Neuroimaging ,Genetic Predisposition to Disease ,Risk Factors ,Apolipoproteins E ,Magnetic Resonance Imaging ,Atrophy ,Machine Learning ,Alzheimer’s Disease Neuroimaging Initiative ,Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing - Abstract
Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer's disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2-7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. We first show genetic risk links with more brain loss than expected for age in early Braak regions, and find this extends beyond APOE genotype. Next, we run machine learning on AD-control data from the Alzheimer's Disease Neuroimaging Initiative using brain change trajectories conditioned on age, to identify AD-sensitive features and model their change in healthy adults. Genetic AD-risk linked with multivariate change across many AD-sensitive features, and we show most individuals over age ~50 are on an accelerated trajectory of brain loss in AD-sensitive regions. Finally, high genetic risk adults with elevated brain change showed more memory decline through adulthood, compared to high genetic risk adults with less brain change. Our findings suggest quantitative AD risk factors are detectable in healthy individuals, via a shared pattern of ageing- and AD-related neurodegeneration that occurs along a continuum and tracks memory decline through adulthood.
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- 2024
7. Funhouse Mirror or Echo Chamber? A Methodological Approach to Teaching Critical AI Literacy Through Metaphors
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Roe, Jasper, Furze, Leon, and Perkins, Mike
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Computer Science - Computers and Society - Abstract
As educational institutions grapple with teaching students about increasingly complex Artificial Intelligence (AI) systems, finding effective methods for explaining these technologies and their societal implications remains a major challenge. This study proposes a methodological approach combining Conceptual Metaphor Theory (CMT) with UNESCO's AI competency framework to develop Critical AI Literacy (CAIL). Through a systematic analysis of metaphors commonly used to describe AI systems, we develop criteria for selecting pedagogically appropriate metaphors and demonstrate their alignment with established AI literacy competencies, as well as UNESCO's AI competency framework. Our method identifies and suggests four key metaphors for teaching CAIL. This includes GenAI as an echo chamber, GenAI as a funhouse mirror, GenAI as a black box magician, and GenAI as a map. Each of these seeks to address specific aspects of understanding characteristics of AI, from filter bubbles to algorithmic opacity. We present these metaphors alongside interactive activities designed to engage students in experiential learning of AI concepts. In doing so, we offer educators a structured approach to teaching CAIL that bridges technical understanding with societal implications. This work contributes to the growing field of AI education by demonstrating how carefully selected metaphors can make complex technological concepts more accessible while promoting critical engagement with AI systems.
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- 2024
8. DESI 2024 VII: Cosmological Constraints from the Full-Shape Modeling of Clustering Measurements
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Prieto, C. Allende, Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Bonici, M., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chebat, D., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elbers, W., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Joyce, R., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lahav, O., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Matthewson, W., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Valogiannis, G., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yi, L., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological results from the measurement of clustering of galaxy, quasar and Lyman-$\alpha$ forest tracers from the first year of observations with the Dark Energy Spectroscopic Instrument (DESI Data Release 1). We adopt the full-shape (FS) modeling of the power spectrum, including the effects of redshift-space distortions, in an analysis which has been validated in a series of supporting papers. In the flat $\Lambda$CDM cosmological model, DESI (FS+BAO), combined with a baryon density prior from Big Bang Nucleosynthesis and a weak prior on the scalar spectral index, determines matter density to $\Omega_\mathrm{m}=0.2962\pm 0.0095$, and the amplitude of mass fluctuations to $\sigma_8=0.842\pm 0.034$. The addition of the cosmic microwave background (CMB) data tightens these constraints to $\Omega_\mathrm{m}=0.3056\pm 0.0049$ and $\sigma_8=0.8121\pm 0.0053$, while further addition of the the joint clustering and lensing analysis from the Dark Energy Survey Year-3 (DESY3) data leads to a 0.4% determination of the Hubble constant, $H_0 = (68.40\pm 0.27)\,{\rm km\,s^{-1}\,Mpc^{-1}}$. In models with a time-varying dark energy equation of state, combinations of DESI (FS+BAO) with CMB and type Ia supernovae continue to show the preference, previously found in the DESI DR1 BAO analysis, for $w_0>-1$ and $w_a<0$ with similar levels of significance. DESI data, in combination with the CMB, impose the upper limits on the sum of the neutrino masses of $\sum m_\nu < 0.071\,{\rm eV}$ at 95% confidence. DESI data alone measure the modified-gravity parameter that controls the clustering of massive particles, $\mu_0=0.11^{+0.45}_{-0.54}$, while the combination of DESI with the CMB and the clustering and lensing analysis from DESY3 constrains both modified-gravity parameters, giving $\mu_0 = 0.04\pm 0.22$ and $\Sigma_0 = 0.044\pm 0.047$, in agreement with general relativity. [Abridged.], Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/). 55 pages, 10 figures
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- 2024
9. DESI 2024 II: Sample Definitions, Characteristics, and Two-point Clustering Statistics
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Brown, Z., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Demina, R., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Hou, J., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kitaura, F. -S., Kong, H., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Scholte, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the samples of galaxies and quasars used for DESI 2024 cosmological analyses, drawn from the DESI Data Release 1 (DR1). We describe the construction of large-scale structure (LSS) catalogs from these samples, which include matched sets of synthetic reference `randoms' and weights that account for variations in the observed density of the samples due to experimental design and varying instrument performance. We detail how we correct for variations in observational completeness, the input `target' densities due to imaging systematics, and the ability to confidently measure redshifts from DESI spectra. We then summarize how remaining uncertainties in the corrections can be translated to systematic uncertainties for particular analyses. We describe the weights added to maximize the signal-to-noise of DESI DR1 2-point clustering measurements. We detail measurement pipelines applied to the LSS catalogs that obtain 2-point clustering measurements in configuration and Fourier space. The resulting 2-point measurements depend on window functions and normalization constraints particular to each sample, and we present the corrections required to match models to the data. We compare the configuration- and Fourier-space 2-point clustering of the data samples to that recovered from simulations of DESI DR1 and find they are, generally, in statistical agreement to within 2\% in the inferred real-space over-density field. The LSS catalogs, 2-point measurements, and their covariance matrices will be released publicly with DESI DR1., Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/)
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- 2024
10. DESI 2024 V: Full-Shape Galaxy Clustering from Galaxies and Quasars
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Rodríguez-Martínez, F., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the measurements and cosmological implications of the galaxy two-point clustering using over 4.7 million unique galaxy and quasar redshifts in the range $0.1
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- 2024
11. Generative AI in Self-Directed Learning: A Scoping Review
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Roe, Jasper and Perkins, Mike
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Computer Science - Computers and Society ,K.4 - Abstract
This scoping review examines the current body of knowledge at the intersection of Generative Artificial Intelligence (GenAI) and Self-Directed Learning (SDL). By synthesising the findings from 18 studies published from 2020 to 2024 and following the PRISMA-SCR guidelines for scoping reviews, we developed four key themes. This includes GenAI as a Potential Enhancement for SDL, The Educator as a GenAI Guide, Personalisation of Learning, and Approaching with Caution. Our findings suggest that GenAI tools, including ChatGPT and other Large Language Models (LLMs) show promise in potentially supporting SDL through on-demand, personalised assistance. At the same time, the literature emphasises that educators are as important and central to the learning process as ever before, although their role may continue to shift as technologies develop. Our review reveals that there are still significant gaps in understanding the long-term impacts of GenAI on SDL outcomes, and there is a further need for longitudinal empirical studies that explore not only text-based chatbots but also emerging multimodal applications.
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- 2024
12. Generative AI and Agency in Education: A Critical Scoping Review and Thematic Analysis
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Roe, Jasper and Perkins, Mike
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
This scoping review examines the relationship between Generative AI (GenAI) and agency in education, analyzing the literature available through the lens of Critical Digital Pedagogy. Following PRISMA-ScR guidelines, we collected 10 studies from academic databases focusing on both learner and teacher agency in GenAI-enabled environments. We conducted an AI-supported hybrid thematic analysis that revealed three key themes: Control in Digital Spaces, Variable Engagement and Access, and Changing Notions of Agency. The findings suggest that while GenAI may enhance learner agency through personalization and support, it also risks exacerbating educational inequalities and diminishing learner autonomy in certain contexts. This review highlights gaps in the current research on GenAI's impact on agency. These findings have implications for educational policy and practice, suggesting the need for frameworks that promote equitable access while preserving learner agency in GenAI-enhanced educational environments.
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- 2024
13. Creating a dynamic database of finite groups
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Combes, Lewis, Jones, John W., Paulhus, Jennifer, Roe, David, Roy, Manami, and Schiavone, Sam
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Mathematics - Group Theory ,Mathematics - Number Theory - Abstract
A database of abstract groups has been added to the L-functions and Modular Forms Database (LMFDB), available at https://www.lmfdb.org/Groups/Abstract/. We discuss the functionality of the database and what makes it distinct from other available databases of abstract groups. We describe solutions to mathematical problems we encountered while creating the database, as well as connections between the abstract groups database and other collections of objects in the LMFDB.
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- 2024
14. Decoding Academic Integrity Policies: A Corpus Linguistics Investigation of AI and Other Technological Threats
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Mike Perkins and Jasper Roe
- Abstract
This study presents a corpus analysis of academic integrity policies from Higher Education Institutions (HEIs) worldwide, exploring how they address the issues posed by technological threats, such as Automated Paraphrasing Tools and generative-artificial intelligence tools, such as ChatGPT. The analysis of 142 policies conducted in November and December 2022, and May 2023 reveals a gap regarding the mention of AI and associated technologies in the available academic integrity policies. Despite the growing prevalence of these tools in the 6-month period since the release of ChatGPT, no HEIs had produced revised academic integrity policies. Content analysis of 53 guidance documents produced by HEIs suggests an overall positive focus of Gen AI tools, yet advises caution. This study suggests a modification to Bretag et al.'s (Int J Educ Integr 7, 2011) exemplary academic integrity model, introducing "Technological Explicitness" -- emphasizing the need to include explicit guidelines about new technologies in academic integrity policies. These results underscore the urgent need for HEIs to revise their academic integrity policies, considering the evolving landscape of AI and its implications for academic integrity. This paper argues for a multifaceted approach to deal with the issues of integrating technology, education, policy reform, and assessment restructuring to navigate these challenges while upholding academic integrity.
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- 2024
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15. Young People's Recommendations for Accessible, Engaging, and Relevant COVID-19 Research Communication in Australia
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Caitlin H. Douglass, Merryn Roe, Michelle Raggatt, Felicia Schlotthauer, Zay Yar Swe, Stephanie Main, Megan S. C. Lim, and Lindi Masson
- Abstract
Research is often communicated in ways that fail to reach young people. This participatory study explored young people's recommendations for making COVID-19 research communication accessible, engaging, and relevant for young people in Australia. We held eight online Zoom workshops with nine young people (18-21 years). Participants recommended researchers share their findings on platforms young people already use, particularly social media. Young people were more likely to engage with research communicated by trusted sources, particularly medical professionals. To keep young people engaged, researchers needed to clearly communicate one main message and simplify evidence using audio-visual formats. To make research communication more relevant, young people recommended sharing findings that related to their experiences throughout the pandemic and providing young people with opportunities to shape research communication and provide feedback. Findings suggest there are opportunities to make COVID-19 research communication more accessible, engaging, and relevant for young people by incorporating their ideas.
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- 2024
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16. CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed.
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Hwang, Wonmuk, Austin, Steven, Blondel, Arnaud, Boittier, Eric, Boresch, Stefan, Buck, Matthias, Buckner, Joshua, Caflisch, Amedeo, Chang, Hao-Ting, Cheng, Xi, Choi, Yeol, Chu, Jhih-Wei, Crowley, Michael, Cui, Qiang, Damjanovic, Ana, Deng, Yuqing, Devereux, Mike, Ding, Xinqiang, Feig, Michael, Gao, Jiali, Glowacki, David, Gonzales, James, Hamaneh, Mehdi, Harder, Edward, Hayes, Ryan, Huang, Jing, Huang, Yandong, Hudson, Phillip, Im, Wonpil, Islam, Shahidul, Jiang, Wei, Jones, Michael, Käser, Silvan, Kearns, Fiona, Kern, Nathan, Klauda, Jeffery, Lazaridis, Themis, Lee, Jinhyuk, Lemkul, Justin, Liu, Xiaorong, Luo, Yun, MacKerell, Alexander, Major, Dan, Meuwly, Markus, Nam, Kwangho, Nilsson, Lennart, Ovchinnikov, Victor, Paci, Emanuele, Park, Soohyung, Pastor, Richard, Pittman, Amanda, Post, Carol, Prasad, Samarjeet, Pu, Jingzhi, Qi, Yifei, Rathinavelan, Thenmalarchelvi, Roe, Daniel, Roux, Benoit, Rowley, Christopher, Shen, Jana, Simmonett, Andrew, Sodt, Alexander, Töpfer, Kai, Upadhyay, Meenu, van der Vaart, Arjan, Vazquez-Salazar, Luis, Venable, Richard, Warrensford, Luke, Woodcock, H, Wu, Yujin, Brooks, Charles, Brooks, Bernard, and Karplus, Martin
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Quantum Theory ,Molecular Dynamics Simulation ,Software - Abstract
Since its inception nearly a half century ago, CHARMM has been playing a central role in computational biochemistry and biophysics. Commensurate with the developments in experimental research and advances in computer hardware, the range of methods and applicability of CHARMM have also grown. This review summarizes major developments that occurred after 2009 when the last review of CHARMM was published. They include the following: new faster simulation engines, accessible user interfaces for convenient workflows, and a vast array of simulation and analysis methods that encompass quantum mechanical, atomistic, and coarse-grained levels, as well as extensive coverage of force fields. In addition to providing the current snapshot of the CHARMM development, this review may serve as a starting point for exploring relevant theories and computational methods for tackling contemporary and emerging problems in biomolecular systems. CHARMM is freely available for academic and nonprofit research at https://academiccharmm.org/program.
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- 2024
17. Generative AI Tools in Academic Research: Applications and Implications for Qualitative and Quantitative Research Methodologies
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Perkins, Mike and Roe, Jasper
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence - Abstract
This study examines the impact of Generative Artificial Intelligence (GenAI) on academic research, focusing on its application to qualitative and quantitative data analysis. As GenAI tools evolve rapidly, they offer new possibilities for enhancing research productivity and democratising complex analytical processes. However, their integration into academic practice raises significant questions regarding research integrity and security, authorship, and the changing nature of scholarly work. Through an examination of current capabilities and potential future applications, this study provides insights into how researchers may utilise GenAI tools responsibly and ethically. We present case studies that demonstrate the application of GenAI in various research methodologies, discuss the challenges of replicability and consistency in AI-assisted research, and consider the ethical implications of increased AI integration in academia. This study explores both qualitative and quantitative applications of GenAI, highlighting tools for transcription, coding, thematic analysis, visual analytics, and statistical analysis. By addressing these issues, we aim to contribute to the ongoing discourse on the role of AI in shaping the future of academic research and provide guidance for researchers exploring the rapidly evolving landscape of AI-assisted research tools and research.
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- 2024
18. The EAP-AIAS: Adapting the AI Assessment Scale for English for Academic Purposes
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Roe, Jasper, Perkins, Mike, and Tregubova, Yulia
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
The rapid advancement of Generative Artificial Intelligence (GenAI) presents both opportunities and challenges for English for Academic Purposes (EAP) instruction. This paper proposes an adaptation of the AI Assessment Scale (AIAS) specifically tailored for EAP contexts, termed the EAP-AIAS. This framework aims to provide a structured approach for integrating GenAI tools into EAP assessment practices while maintaining academic integrity and supporting language development. The EAP-AIAS consists of five levels, ranging from "No AI" to "Full AI", each delineating appropriate GenAI usage in EAP tasks. We discuss the rationale behind this adaptation, considering the unique needs of language learners and the dual focus of EAP on language proficiency and academic acculturation. This paper explores potential applications of the EAP-AIAS across various EAP assessment types, including writing tasks, presentations, and research projects. By offering a flexible framework, the EAP-AIAS seeks to empower EAP practitioners seeking to deal with the complexities of GenAI integration in education and prepare students for an AI-enhanced academic and professional future. This adaptation represents a step towards addressing the pressing need for ethical and pedagogically sound AI integration in language education.
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- 2024
19. Understanding Student and Academic Staff Perceptions of AI Use in Assessment and Feedback
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Roe, Jasper, Perkins, Mike, and Ruelle, Daniel
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence - Abstract
The rise of Artificial Intelligence (AI) and Generative Artificial Intelligence (GenAI) in higher education necessitates assessment reform. This study addresses a critical gap by exploring student and academic staff experiences with AI and GenAI tools, focusing on their familiarity and comfort with current and potential future applications in learning and assessment. An online survey collected data from 35 academic staff and 282 students across two universities in Vietnam and one in Singapore, examining GenAI familiarity, perceptions of its use in assessment marking and feedback, knowledge checking and participation, and experiences of GenAI text detection. Descriptive statistics and reflexive thematic analysis revealed a generally low familiarity with GenAI among both groups. GenAI feedback was viewed negatively; however, it was viewed more positively when combined with instructor feedback. Academic staff were more accepting of GenAI text detection tools and grade adjustments based on detection results compared to students. Qualitative analysis identified three themes: unclear understanding of text detection tools, variability in experiences with GenAI detectors, and mixed feelings about GenAI's future impact on educational assessment. These findings have major implications regarding the development of policies and practices for GenAI-enabled assessment and feedback in higher education.
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- 2024
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20. Recovery at 30: Integrating Lived Experience Expertise into Mental Health Research in Israel
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Alfia-Burstein, Shira, Oren, Avi, Goldfarb, Yael, Stengar-Elran, Renana, Pinfold, Vanessa, Roe, David, and Moran, Galia S.
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- 2025
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21. Environmental life cycle assessment of drink and yoghurt products using non-nutritive sweeteners and sweetness enhancers in place of added sugar: the SWEET project
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Suckling, J., Morse, S., Murphy, R., Raats, M., Astley, S., Ciruelos, A., Crespo, A., Halford, J. C. G., Harrold, J. A., Le-Bail, A., Koukouna, E., Musinovic, H., Raben, A., Roe, M., Scholten, J., Scott, C., and Westbroek, C.
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- 2025
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22. Antipsychotic Discontinuation through the Lens of Epistemic Injustice
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Speyer, Helene, Eplov, Lene Falgaard, and Roe, David
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- 2025
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23. Promoting Reflection on the Process of Recovery: Unique Contributions from Literature and the Humanities for Practitioner
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Lysaker, Paul H., Roe, David, and Lysaker, John T.
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- 2025
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24. Antipsychotics and Identity: The Adverse Effect No One is Talking About
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Conneely, M., Roe, D., Hasson-Ohayon, I., Pijnenborg, G. H. M., van der Meer, L., and Speyer, H.
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- 2025
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25. Infertility and risk of ovarian cancer in the women’s health initiative
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Harris, Holly R., Lind, Kimberly, Fest, Sable, Thomson, Cynthia A., Saquib, Nazmus, Shadyab, Aladdin H., Schnatz, Peter F., Robles-Morales, Rogelio, Qi, Lihong, Strickler, Howard D., Roe, Denise J., and Farland, Leslie V.
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- 2025
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26. Lcd codes over F2+uF2 with small dimensions
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Kim, Jon-Lark and Roe, Young Gun
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- 2025
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27. Optimising Instrumented Mouthguard Data Analysis: Video Synchronisation Using a Cross-correlation Approach: Optimising instrumented mouthguard data ...
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Tooby, James, Rowson, Steve, Till, Kevin, Allan, David, Bussey, Melanie Dawn, Cazzola, Dario, Falvey, Éanna, Friesen, Kenzie, Gardner, Andrew J., Owen, Cameron, Roe, Gregory, Sawczuk, Thomas, Starling, Lindsay, Stokes, Keith, Tierney, Gregory, Tucker, Ross, and Jones, Ben
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- 2025
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28. A prospective ecological momentary assessment study of an ayahuasca retreat: exploring the salutary impact of acute psychedelic experiences on subacute affect and mindfulness skills in daily life
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Sznitman, Sharon R., Behar, Yoel A., Dicker-Oren, Sheila Daniela, Shochat, Tamar, Meiri, David, Butto, Nader, Roe, David, and Bernstein, Amit
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- 2025
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29. Multiple loci for foveolar vision in macaque monkey visual cortex
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Qian, Meizhen, Wang, Jianbao, Gao, Yang, Chen, Ming, Liu, Yin, Zhou, Dengfeng, Lu, Haidong D., Zhang, Xiaotong, Hu, Jia Ming, and Roe, Anna Wang
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- 2025
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30. Anti-obesity medication patients’ self-reported food savings versus the cost of such medicines: Health Economics
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Roe, Brian E.
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- 2024
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31. Effects of Transcranial Electrical Stimulation on Physiological Responses to Acute Stress: A Systematic Review
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Hart-Pomerantz, Hannah, Roe, Elizabeth, and Brunyé, Tad T.
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- 2024
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32. Climate change and poorer economies: some reflections after COPs 27 and 28: Climate Change and Poorer Economies: Some Reflections after COPs 27 and 28
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Roe, Alan R.
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- 2024
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33. Experiences with healthcare navigation and bias among adult women with sickle cell disease: a qualitative study
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Wu, Jessica K., McVay, Kyler, Mahoney, Katherine M., Sayani, Farzana A., Roe, Andrea H., and Cebert, Morine
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- 2024
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34. Everyday ageism experienced by community-dwelling older people with frailty
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Comerford, Saidhbh, O’Kane, Ellie, Roe, Domhnall, Alsharedah, Hamad, O’Neill, Benny, Walsh, Michael, and Briggs, Robert
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- 2024
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35. Musings of a Computational Philosopher
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Roe, Philip, Tyacke, James C., editor, and Vadlamani, Nagabhushana Rao, editor
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- 2025
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36. An Ecologist’s Personal Investigation: Sandra Steingraber on Danger, Ecology, and Writing
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Roe, Mileta, Joseph, Sue, Series Editor, McDonald, Willa, Series Editor, Ricketson, Matthew, Series Editor, and Calvi, Pablo, editor
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- 2025
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37. Deepfakes and Higher Education: A Research Agenda and Scoping Review of Synthetic Media
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Roe, Jasper and Perkins, Mike
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
The availability of software which can produce convincing yet synthetic media poses both threats and benefits to tertiary education globally. While other forms of synthetic media exist, this study focuses on deepfakes, which are advanced Generative AI (GenAI) fakes of real people. This conceptual paper assesses the current literature on deepfakes across multiple disciplines by conducting an initial scoping review of 182 peer-reviewed publications. The review reveals three major trends: detection methods, malicious applications, and potential benefits, although no specific studies on deepfakes in the tertiary educational context were found. Following a discussion of these trends, this study applies the findings to postulate the major risks and potential mitigation strategies of deepfake technologies in higher education, as well as potential beneficial uses to aid the teaching and learning of both deepfakes and synthetic media. This culminates in the proposal of a research agenda to build a comprehensive, cross-cultural approach to investigate deepfakes in higher education.
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- 2024
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38. DESI 2024 VI: Cosmological Constraints from the Measurements of Baryon Acoustic Oscillations
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Bera, A., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Ravoux, C., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Ureña-López, L. A., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., and Zou, H.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological results from the measurement of baryon acoustic oscillations (BAO) in galaxy, quasar and Lyman-$\alpha$ forest tracers from the first year of observations from the Dark Energy Spectroscopic Instrument (DESI), to be released in the DESI Data Release 1. DESI BAO provide robust measurements of the transverse comoving distance and Hubble rate, or their combination, relative to the sound horizon, in seven redshift bins from over 6 million extragalactic objects in the redshift range $0.1
-1$ and $w_a<0$. This preference is 2.6$\sigma$ for the DESI+CMB combination, and persists or grows when SN~Ia are added in, giving results discrepant with the $\Lambda$CDM model at the $2.5\sigma$, $3.5\sigma$ or $3.9\sigma$ levels for the addition of Pantheon+, Union3, or DES-SN5YR datasets respectively. For the flat $\Lambda$CDM model with the sum of neutrino mass $\sum m_\nu$ free, combining the DESI and CMB data yields an upper limit $\sum m_\nu < 0.072$ $(0.113)$ eV at 95% confidence for a $\sum m_\nu>0$ $(\sum m_\nu>0.059)$ eV prior. These neutrino-mass constraints are substantially relaxed in models beyond $\Lambda$CDM. [Abridged.], Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers). 68 pages, 15 figures. Version accepted for publication in JCAP - Published
- 2024
39. DESI 2024 IV: Baryon Acoustic Oscillations from the Lyman Alpha Forest
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Bautista, J., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Cruz, R., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, J., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçayli, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Sinigaglia, F., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the measurement of Baryon Acoustic Oscillations (BAO) from the Lyman-$\alpha$ (Ly$\alpha$) forest of high-redshift quasars with the first-year dataset of the Dark Energy Spectroscopic Instrument (DESI). Our analysis uses over $420\,000$ Ly$\alpha$ forest spectra and their correlation with the spatial distribution of more than $700\,000$ quasars. An essential facet of this work is the development of a new analysis methodology on a blinded dataset. We conducted rigorous tests using synthetic data to ensure the reliability of our methodology and findings before unblinding. Additionally, we conducted multiple data splits to assess the consistency of the results and scrutinized various analysis approaches to confirm their robustness. For a given value of the sound horizon ($r_d$), we measure the expansion at $z_{\rm eff}=2.33$ with 2\% precision, $H(z_{\rm eff}) = (239.2 \pm 4.8) (147.09~{\rm Mpc} /r_d)$ km/s/Mpc. Similarly, we present a 2.4\% measurement of the transverse comoving distance to the same redshift, $D_M(z_{\rm eff}) = (5.84 \pm 0.14) (r_d/147.09~{\rm Mpc})$ Gpc. Together with other DESI BAO measurements at lower redshifts, these results are used in a companion paper to constrain cosmological parameters., Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers). Minor changes in v4, version accepted for publication in JCAP
- Published
- 2024
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40. DESI 2024 III: Baryon Acoustic Oscillations from Galaxies and Quasars
- Author
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Swanson, J., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the DESI 2024 galaxy and quasar baryon acoustic oscillations (BAO) measurements using over 5.7 million unique galaxy and quasar redshifts in the range 0.1
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- 2024
41. GenAI Detection Tools, Adversarial Techniques and Implications for Inclusivity in Higher Education
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Perkins, Mike, Roe, Jasper, Vu, Binh H., Postma, Darius, Hickerson, Don, McGaughran, James, and Khuat, Huy Q.
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
This study investigates the efficacy of six major Generative AI (GenAI) text detectors when confronted with machine-generated content that has been modified using techniques designed to evade detection by these tools (n=805). The results demonstrate that the detectors' already low accuracy rates (39.5%) show major reductions in accuracy (17.4%) when faced with manipulated content, with some techniques proving more effective than others in evading detection. The accuracy limitations and the potential for false accusations demonstrate that these tools cannot currently be recommended for determining whether violations of academic integrity have occurred, underscoring the challenges educators face in maintaining inclusive and fair assessment practices. However, they may have a role in supporting student learning and maintaining academic integrity when used in a non-punitive manner. These results underscore the need for a combined approach to addressing the challenges posed by GenAI in academia to promote the responsible and equitable use of these emerging technologies. The study concludes that the current limitations of AI text detectors require a critical approach for any possible implementation in HE and highlight possible alternatives to AI assessment strategies.
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- 2024
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42. The AI Assessment Scale (AIAS) in action: A pilot implementation of GenAI supported assessment
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Furze, Leon, Perkins, Mike, Roe, Jasper, and MacVaugh, Jason
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
The rapid adoption of Generative Artificial Intelligence (GenAI) technologies in higher education has raised concerns about academic integrity, assessment practices, and student learning. Banning or blocking GenAI tools has proven ineffective, and punitive approaches ignore the potential benefits of these technologies. This paper presents the findings of a pilot study conducted at British University Vietnam (BUV) exploring the implementation of the Artificial Intelligence Assessment Scale (AIAS), a flexible framework for incorporating GenAI into educational assessments. The AIAS consists of five levels, ranging from 'No AI' to 'Full AI', enabling educators to design assessments that focus on areas requiring human input and critical thinking. Following the implementation of the AIAS, the pilot study results indicate a significant reduction in academic misconduct cases related to GenAI, a 5.9% increase in student attainment across the university, and a 33.3% increase in module passing rates. The AIAS facilitated a shift in pedagogical practices, with faculty members incorporating GenAI tools into their modules and students producing innovative multimodal submissions. The findings suggest that the AIAS can support the effective integration of GenAI in HE, promoting academic integrity while leveraging the technology's potential to enhance learning experiences.
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- 2024
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43. Structural Assessment of Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-Derived Vaccine Antigens and Immunological Profiling in Mice with Different Genetic Backgrounds.
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Roe, Shea, Zhu, Tianmou, Slepenkin, Anatoli, Berges, Aym, Fairman, Jeff, de la Maza, Luis, and Massari, Paola
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B-cell epitopes ,Chlamydia trachomatis ,MOMP ,antibodies ,vaccine - Abstract
Chlamydia trachomatis (Ct) is the most common cause of bacterial sexually transmitted infections (STIs) worldwide. Ct infections are often asymptomatic in women, leading to severe reproductive tract sequelae. Development of a vaccine against Chlamydia is crucial. The Chlamydia major outer membrane protein (MOMP) is a prime vaccine antigen candidate, and it can elicit both neutralizing antibodies and protective CD4+ T cell responses. We have previously designed chimeric antigens composed of immunogenic variable regions (VDs) and conserved regions (CDs) of MOMP from Chlamydia muridarum (Cm) expressed into a carrier protein (PorB), and we have shown that these were protective in a mouse model of Cm respiratory infection. Here, we generated corresponding constructs based on MOMP from Ct serovar F. Preliminary structure analysis of the three antigens, PorB/VD1-3, PorB/VD1-4 and PorB/VD1-2-4, showed that they retained structure features consistent with those of PorB. The antigens induced robust humoral and cellular responses in mice with different genetic backgrounds. The antibodies were cross-reactive against Ct, but only anti-PorB/VD1-4 and anti-PorB/VD1-2-4 IgG antibodies were neutralizing, likely due to the antigen specificity. The cellular responses included proliferation in vitro and production of IFN-γ by splenocytes following Ct re-stimulation. Our results support further investigation of the PorB/VD antigens as potential protective candidates for a Chlamydia subunit vaccine.
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- 2024
44. Safety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation
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Goodman, Shaun G, Steg, Philippe Gabriel, Szarek, Michael, Bhatt, Deepak L, Bittner, Vera A, Diaz, Rafael, Harrington, Robert A, Jukema, J Wouter, White, Harvey D, Zeiher, Andreas M, Manvelian, Garen, Pordy, Robert, Poulouin, Yann, Stipek, Wanda, Garon, Genevieve, Schwartz, Gregory G, Steg, Ph Gabriel, Tricoci, Pierluigi, Roe, Matthew T, Mahaffey, Kenneth W, Edelberg, Jay M, Hanotin, Corinne, Lecorps, Guillaume, Moryusef, Angèle, Sasiela, William J, Tamby, Jean-François, Aylward, Philip E, Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Lopes, Renato D, Gotcheva, Nina N, Prieto, Juan-Carlos, Yong, Huo, López-Jaramillo, Patricio, Pećin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S, Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Valdovinos, Pablo Carlos Montenegro, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Erglis, Andrejs, Laucevicius, Aleksandras, Kedev, Sasko, Yusoff, Khalid, López, Gabriel Arturo Ramos, Alings, Marco, Halvorsen, Sigrun, Flores, Roger M Correa, Sy, Rody G, Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Karpov, Yuri, Ristic, Arsen D, Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J, Tuñón, José, de Silva, H Asita, Hagström, Emil, Landmesser, Ulf, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K, Moriarty, Patrick M, Chaitman, Bernard, Kelsey, Sheryl F, Olsson, Anders G, and Rouleau, Jean-Lucien
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Patient Safety ,Clinical Research ,6.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Antibodies ,Monoclonal ,Humanized ,Anticholesteremic Agents ,Biomarkers ,Cardiovascular Diseases ,Cholesterol ,LDL ,Dyslipidemias ,PCSK9 Inhibitors ,Proprotein Convertase 9 ,Randomized Controlled Trials as Topic ,Serine Proteinase Inhibitors ,Time Factors ,Treatment Outcome ,ODYSSEY OUTCOMES Investigators ,Alirocumab ,Cholesterol ,PCSK9 ,Safety ,Cardiorespiratory Medicine and Haematology ,Pharmacology and Pharmaceutical Sciences ,Cardiovascular medicine and haematology ,Pharmacology and pharmaceutical sciences - Abstract
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.
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- 2024
45. Cervicovaginal Metabolome and Tumor Characteristics for Endometrial Cancer Detection and Risk Stratification.
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Lorentzen, Georgia, Łaniewski, Paweł, Cui, Haiyan, Mahnert, Nichole, Mourad, Jamal, Borst, Matthew, Willmott, Lyndsay, Chase, Dana, Roe, Denise, and Herbst-Kralovetz, Melissa
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Humans ,Female ,Endometrial Neoplasms ,Metabolome ,Vagina ,Middle Aged ,Biomarkers ,Tumor ,Aged ,Metabolomics ,Prognosis ,Risk Assessment ,Cervix Uteri ,Adult ,Carcinoma ,Endometrioid - Abstract
PURPOSE: Endometrial cancer is highly prevalent and lacking noninvasive diagnostic techniques. Diagnosis depends on histological investigation of biopsy samples. Serum biomarkers for endometrial cancer have lacked sensitivity and specificity. The objective of this study was to investigate the cervicovaginal environment to improve the understanding of metabolic reprogramming related to endometrial cancer and identify potential biomarker candidates for noninvasive diagnostic and prognostic tests. EXPERIMENTAL DESIGN: Cervicovaginal lavages were collected from 192 participants with endometrial cancer (n = 66) and non-malignant conditions (n = 108), and global untargeted metabolomics was performed. Using the metabolite data (n = 920), we completed a multivariate biomarker discovery analysis. RESULTS: We analyzed grade 1/2 endometrioid carcinoma (n = 53) and other endometrial cancer subtypes (n = 13) to identify shared and unique metabolic signatures between the subtypes. When compared to non-malignant conditions, downregulation of proline (P < 0.0001), tryptophan (P < 0.0001), and glutamate (P < 0.0001) was found among both endometrial cancer groups, relating to key hallmarks of cancer including immune suppression and redox balance. Upregulation (q < 0.05) of sphingolipids, fatty acids, and glycerophospholipids was observed in endometrial cancer in a type-specific manner. Furthermore, cervicovaginal metabolites related to tumor characteristics, including tumor size and myometrial invasion. CONCLUSIONS: Our findings provide insights into understanding the endometrial cancer metabolic landscape and improvement in diagnosis. The metabolic dysregulation described in this article linked specific metabolites and pathophysiological mechanisms including cellular proliferation, energy supply, and invasion of neighboring tissues. Furthermore, cervicovaginal metabolite levels related to tumor characteristics, which are used for risk stratification. Overall, development of noninvasive diagnostics can improve both the acceptability and accessibility of diagnosis.
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- 2024
46. Investigating Pragmatic Abilities in 5- to 7-Year-Old Norwegian Children: A Study Using the Pragma Test
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Wenche A. Helland, Eline Aaland, Karoline L. Furebotn, Junna Nilsen, Helene Pettersen, Anne Lise Roe, Ann Kristin S. Wathne, and Frøydis Morken
- Abstract
Pragmatics refers to the ability to effectively use and interpret language in different contexts. Pragmatic abilities develop and refine through childhood, and they are essential for socialization, academic achievement and wellbeing. The scarcity of assessment tools in this field makes it challenging to provide a comprehensive assessment of pragmatic abilities. The Pragma test, originally developed for Finnish and also adapted into Italian, consists of a battery of tasks assessing children's pragmatic abilities. In this study, a first evaluation of the psychometric qualities of a Norwegian adaptation of this test is presented. In addition, we investigated pragmatic development between ages 5 and 7, and explored possible gender-based differences. Altogether 119 Norwegian-speaking children participated in the study. The children were tested with the Pragma test and parents completed the Children's Communication Checklist-2. The children were allocated into three groups: 5-year-olds, 6-year-olds and 7-year-olds. The psychometric qualities of this Norwegian adaptation supported its use as a tool for assessing pragmatics in children aged 5-7. Strong and significant growth in pragmatic competence was observed from age 5-6, subsequently flattening out between age 6 and 7, and gender differences in favour of girls were identified. These findings indicate that pragmatic ability, as measured by the Pragma test, shows similar age effects in a Norwegian setting as in Finnish and Italian contexts, paving the way for further cross-cultural and cross-linguistic studies.
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- 2024
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47. A Cross-Disciplinary Approach to Learning Medical Physiology and Behavioral Skills Involving Drama Students Performing as Simulated Patients
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Seán Roe, Mary K. McGahon, Sharon Parkinson, Etain Tansey, and Paul Murphy
- Abstract
The early years of physiology education in medical curricula provide unique challenges. As well as inculcating concepts that are seen as difficult, modern curricula require that students learn in context in case-based learning courses. Additionally, regulating bodies stress that the soft skills of compassion, communication, and empathy are embedded throughout curricula. This has driven work in our organization involving drama and final-year medicine students during which they collaborate in realistic simulations of doctor/patient interactions. We adapted this transdisciplinary approach to second-year physiology tutorials. This emphasized the holistic importance of physiology to patient care, while also embedding "human factors" skills from the very earliest stages of the curriculum. After preparing by attending acting classes based on aspects of Konstantin Stanislavski's "System," the authors supervised tutorials in which drama students participated in a "physiology of hypofertility" session for second-year medical students, playing a 34-year-old woman with premature menopause (or their partner). Opinion (from all students) was evaluated by Likert questionnaires (which included open questions). A focus group of drama students was also interviewed, and the conversation was recorded for thematic analysis. Positive Likert scores were recorded for the authenticity of the tutorials, skills development, fostering empathy, and motivating students to improve. All participants evaluated the tutorial as highly enjoyable. These scores are reflected in positive open commentary on the questionnaires and in the focus group interviews. The results suggest that even basic science tutorials give opportunities for interdisciplinary study and enhancement of behavioral skills while gaining enthusiastic student acceptance.
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- 2024
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48. Mood Disorder Public Stigma in Jewish Communities in the United States
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Smith, Limor L., Brewer, Kathryne B., Carr, L. Christian, Roe, David, and Gearing, Robin E.
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- 2024
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49. EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401
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Nam, Young Woo, Shin, June-Ha, Kim, Seongmi, Hwang, Chi Hyun, Lee, Choong-Sil, Hwang, Gyuho, Kim, Hwa-Ryeon, Roe, Jae-Seok, and Song, Jaewhan
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- 2024
- Full Text
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50. Divisions within the British Parliamentary Labour Party under Keir Starmer: Results of a Cluster Analysis
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Jeffery, David, Roe-Crines, Andrew S., and Heppell, Timothy
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- 2024
- Full Text
- View/download PDF
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