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Objective: This research analyzed in vitro the antifungal activity of the solution composed by grapes seed extract Vitis vinifera (Doctor’s A-Z®) against Candida albicans (ATCC 20231) species aiming to determine the minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC). Methods: To that, were used micro dilution boards of 96 wells where the strain of Candida. Was tested the diluted solutions in distilled water on the concentrations 0.20 g/mL, 0.30 g/mL and 0.40 g/mL. As growing control were used growing fungous, to test the viability of the strains. As positive control, was used nystatin (commercial suspension 100,000 UI/mL) and as sterility control of growing way. The tests were conducted in triplicate and the data obtained were analyzed through the exam Kruskal-Wallis, with significance level of 95% (p

Temporomandibular disorder (TMD) is the term used in Dentistry to define the structural and disorder changes affect the physiology of the masticatory system composed of TMJ and related to musculoskeletal structures. Objective: To conduct a descriptive, transversal and documentary study aiming to determine the profile of 14 TMD patients undergoing simultaneous dental and physiotherapeutic treatment at a private practice of the city of Fortaleza-Ce. Material and methods: The following instruments for the collection of the data were employed: files registering the evaluation and evolution, findings of the radiographic examinations and forms. Data were statistically analyzed through SPSS software, version 10.0. Results: Most of the sample was composed by females aged 32 years (+/-10.60) in average, mainly complaining about chronic headache, masticatory myalgia , TMJ pain, cervicalgy, otalgia, among others. The complete sample presented, at least, one pathology associated to and/or concomitant to TMD. The radiographic findings showed TMJ alterations and tooth losses. Analgesics were the most used drugs. Conclusion: TMD is a complex syndrome, with many etiologies and symptoms, aggravating and perpetuating factors, requiring multiple and even more specialized therapeutic management attempting treatment success.

The dental decay is a sugar-dependent condition that can be defined as the process of demineralization of the dental head office in the enamel and/or dentine induced by acid middle, presenting multiples factors that can modulate that road. The própolis comes as a responsible resin for the sealing of the beehives of bees (Apis mellifera), being originating from his/her collection in several types of vegetables. Now knowledge is had of at least 200 types of identified compositions in the própolis, starting from different geographical samples and of the botanical diversity. The chemical characterization of the própolis standardized constituent as: fenolics prenilads acids, lignans, terpens and terpenics alcohols , besides having derived p-curmarinics. Varnish base of natural products has been studied in researches in vitro as agents anti-decay. They were not found, in the literature, reports of the varnish use the base of Brazilian red própolis, as well as clinical rehearsals comparing those varnish the other ones. This study looked for to accomplish the development, clinical evaluation and microbiological of dental varnish of red própolis about reduction of streptococcus mutans in children, with purpose of prevention of the dental decay. It is a clinical rehearsal, randomized, double-blind and longitudinal, controlled. They were selected, for participation of the study, 99 children. Firstly he/she took place a pilot study to verify the best concentration of the própolis varnish to feel continuation to the clinical rehearsal in which the volunteers were divided in 3 groups accompanied by 360 days: clorexidina varnish, Fluor varnish and própolis varnish. There was expressive reduction of the microbial load, with statistical significance, of streptococcus mutans on 90 and 180 after the application of the própolis varnish in relation to the group treated with the clorexidina varnish and with the flúor varnish. Concui-if that dental varnish of Brazilian red própolis 2,5% were shown effective in the control of the units forming of colonies of Streptococcus mutans in the oral cavity, when used in the interval of 90 days. A cárie dentária é uma condição açúcar-dependente que pode ser definida como o processo de desmineralização da matriz dentária no esmalte e/ou dentina induzida por meio ácido, apresentando múltiplos fatores que podem modular essa via. A própolis se apresenta como uma resina responsável pelo selamento das colmeias de abelhas (Apis mellifera), sendo proveniente da coleta delas em diversos tipos de vegetais. Atualmente se tem conhecimento de pelo menos 200 tipos de compostos identificados na própolis, a partir de amostras geográficas diferentes e da diversidade botânica. A caracterização química da própolis padronizou constituintes como: ácidos fenólicos prenilados, lignanas, terpenos e alcoóis terpênicos, além de derivados p-curmarínicos. Vernizes a base de produtos naturais vêm sendo estudados em pesquisas in vitro como agentes anti-cárie. Não foram encontrados, na literatura, relatos da utilização de vernizes a base de própolis vermelha brasileira, bem como ensaios clínicos comparando esses vernizes a outros. Este estudo buscou realizar o desenvolvimento, avaliação clínica e microbiológica de verniz dentário de própolis vermelha sobre redução de streptococcus mutans em crianças, com finalidade de prevenção da cárie dentária. Trata-se de um ensaio clínico, randomizado, duplo-cego e longitudinal, controlado. Foram selecionadas, para participação do estudo, 99 crianças. Primeiramente se realizou um estudo piloto para verificar a melhor concentração do verniz de própolis para se dar seguimento ao ensaio clínico no qual os voluntários foram divididos em 3 grupos acompanhados por 360 dias: verniz de clorexidina, verniz de Fluor e verniz de própolis. Houve expressiva redução da carga microbiana, com significância estatística, de streptococcus mutans nos dias 90 e 180 após a aplicação do verniz de própolis em relação ao grupo tratado com o verniz de clorexidina e com o verniz de flúor. Conclui-se que verniz dentário de própolis vermelha brasileira 2,5% se mostrou eficaz no controle das unidades formadoras de colônias de Streptococcus mutans na cavidade oral, quando utilizado no intervalo de 90 dias.

Oral-maxillo-facial specialty aims at diagnosing and treating diseases, trauma, injury and congenital and acquired anomalies, of the masticatory apparatus, its annexes and associated structures. Multidisciplinary follow-up in postoperatively is necessary to prevent infections, aesthetic deformities and functional changes resulting from surgery and etiology for which it was nominated. Reporting the functional changes and intra-hospital therapeutic approach in the postoperative period of an oralmaxillo-facial service. We conducted a field survey, documentary, cross-sectional and quantitative with patients in post-operative oral-maxillo-facial surgery who were in the infirmary units in the General Hospital of Fortaleza (HGF). Data were collected from medical records of patients through a statement made by its own researchers. Data were statistically analyzed by the software Statistical Package for The Social Science (SPSS), version 20. We analyzed 26 medical records. Most patients were male, 14 (53,8%). The most prevalent age group was between 35 to 49 years old with 11 (42,3%) from the patients. The most frequent causes of oral-maxillo-facial disorders were the physical aggressions and falls, with eight (30,8%) patients each. The jaw was the most affected place, with nine (34,6%) cases. From the most affected movement limitations we find the mouth opening 9 (34,6%), as the most restricted movement. There was a predominance of male patients, aged between 35 and 49, affected by physical assaults and falls that led to the trauma. The presence of limitations was significant, making it clear the need for physiotherapy monitoring.

Local anesthetics are commonly used in surgical procedures, they are able to promote a reversible blockade of nerve conduction, with loss of sensation in circumscribed area of the body without changing the individual's level of consciousness. The aim of this study was to review the literature that can compose the body of evidence on efficacy and safety of Lipid Emulsion (ELI) for use as an antidote in the treatment of intoxication by local anesthetics and other lipofílicos. Trata is a review drugs literature that we used the Fat Emulsions terms Intravenous AND Antidotes for the search in the following databases: Pubmed; Cochrane Library and Trip Database and were raised studies found in these bases until November 2015. The review conducted showed that the use of ELI as an antidote seems to be a possible alternative for the treatment of poisoning caused by local anesthetics and other lipophilic drugs. Recently the ELI have been used also as an antidote against cardiovascular collapse induced by bupivacaine and other local anesthetics lipophilic. Early studies reported more frequently the use of Intralipid®, intravenously, which is sold in formulations containing soybean oil at different concentrations (10, 20 or 30%) in admixture with other lipids and phospholipids. The effects produced by Intralipid® have also been attributed to other lipid emulsions of formulations composed of different extracts of oils. However, current evidence supporting this use are scarce and uncertain, pointing to the need for additional studies. With respect to this fact, recently the American Academy of Clinical Toxicology.

Objectives: To monitor patients being treated with tyrosine kinase inhibitors, describing the problems related to drug during the follow-up. Methods: this work is a descriptive and prospective study, conducted during the pharmaceutical care to patients of chronic myeloid leukemia clinic of the Hospital Universitário Walter Cantídio in the Universidade Federal do Ceará, from September 2012 to August 2013. The pharmaceutical interventions were classified systematically and the statistical analyzes were performed using Epi Info v. 3.5.1 program. They were followed a total of 74 patients. Results: we identified 258 problems related to the drug and in return were held 267 pharmaceutical interventions. Conclusions: from the above we can see the importance of individual monitoring of patients through the practice of pharmaceutical care, performing guidelines regarding the treatment with tyrosine kinase inhibitors by monitoring drug therapy and providing information on major adverse reactions, thus ensuring a good adherence to treatment. Objetivos: Acompanhar pacientes em tratamento com inibidores da tirosina quinase, descrevendo os problemas relacionados ao medicamento identificados durante o acompanhamento. Material e Métodos: este trabalho se trata de um estudo descritivo e prospectivo, realizado durante o atendimento farmacêutico aos pacientes do ambulatório de leucemia mieloide crônica do Hospital Universitário Walter Cantídio da Universidade Federal do Ceará, no período de setembro 2012 a agosto de 2013. As intervenções farmacêuticas foram classificadas sistematicamente e as análises estatísticas realizadas no programa Epi Info v. 3.5.1. Foram acompanhados, no total, 74 pacientes. Resultados: foram identificados 258 problemas relacionados ao medicamento e em contrapartida foram realizadas 267 intervenções farmacêuticas. Conclusões: pelo exposto percebe-se importância do monitoramento individual dos pacientes através da prática da atenção farmacêutica, realizando orientações a respeito do tratamento com os inibidores da tirosina quinase, monitorando a farmacoterapia e fornecendo as informações sobre as principais reações adversas, garantindo assim uma boa adesão ao tratamento.

The energy density of low power, laser and electromagnetic field , has been used in recent years quite often in the medical field . The study of labeling red blood cells with technetium 99m is used for various evaluations in nuclear medicine including the study of blood volume in neurological intensive care . The aim was to evaluate the in fluence of non - ionizing radiation on the red blood cells labeled in vitro . B lood samples from rats of the Wistar strain divided into two groups were used. The first group used the EDTA and heparin as anticoagulants and received low - power laser induction ( L PL) in the following separately energy density : 3, 6, 9 and 18J/cm². The second group received an electromagnetic field (EMF ) of 60 Hz for 2, 4 , 17 and 21 hours separately . After the induction of the laser and the electromagnetic field , the blood samples w ere labeled with technetium - 99m ( 99mTc). The results indicate that the presence of anticoagulants is able to modify the uptake of technetium - 99m by red blood cells . The laser induced decreases the binding capacity of the technetium - 99m from 3J/cm². From th e foregoing it was found that the radiation is non - ionizing EMF with LBP or alters the binding capacity of 99mTc the erythrocytes and the use of heparin as an anticoagulant gave also a higher labeling efficiency compared with the use of EDTA.The non - ionizi ng radiation has a promising power applications of biomedical sciences can be used for marking targets macromolecules in the body in order to diagnostic procedures and disease control.

The objective was to identify the frequency, age and gender of the elderly victims of head trauma, a dmitted to an intensive care unit (ICU). Retrospective study of descriptive and documentary nature, conducted with medical records of elderly patients suffering from brain injury trauma ICU of an emergency care hospital located in Fortaleza, Ceará. The res earch period was from January to August 2013. The results showed that the determinants of hospitalization among the elderly in the ICU were: fall from own height, car accident, fall from the first floor, stair fall, beating and unknown factor. In conclusio n, the elderly require special and differentiated attention, mainly because of their physical condition, so that way they can carry out their daily activities without compromising their mobility, avoiding accidents such as those mentioned.

The objective of this study was to analyze the spatial and temporal distribution of cases of Hepatitis B in the states of northeastern Brazil. This is an ecological study of the spatial and temporal distribution, by gender, age group and race of all cases of hepatitis B of the Brazilian Northeast, reported in the period from 2007 to 2013. The data were organized and processed in SPSS ® version 20 and analyzed using descriptive statistics and linear regression. Regarding t he spatial distribution , a vector map was constructed using the program QGis2.4.0 ® version Chugiak. In the analyzed period , there were 7,922 cases of Hepatitis B. There was an increase of 121 cases per year (p

For the reconstruction of the anterior teeth that have suffered fractures or restorations involving the incisal angle of the dentistry offers a treatment that offers the ideal copy of the palatal structure, the restoration technique using the wall of silicone. This technique allows to recover the aesthetics of fast, conservatively, and offers a great advantage for dentistry as reducing chair time the child patient. The aim of this study was to report a case where the technique of silicone wall in pediatric patients was applied. Patient MED, female gender, Caucasian race, age 7, showing oblique fracture of the crowns of teeth 11:21. After emergency procedures, the patient had their molded arches and rear molding plaster, wax reconstruction, placement of the wall and restoration of fractured teeth. The case was solved only with resources dentistry, art on the wall, using wax- and light-curing composite resins, reaching a good aesthetic result. Therefore, it is concluded that the technique of making the silicone wall to direct restoration in anterior teeth has advantages in time spent in performing the medical procedure besides satisfying and aesthetic result. Para a reconstrução de dentes anteriores que sofreram fraturas ou restaurações envolvendo o ângulo incisal, a dentística dispõe de um tratamento que oferece a cópia ideal da estrutura palatina, a técnica de restauração usando a muralha de silicona. Esta técnica permite recuperar a estética de forma rápida, conservadora e oferece uma grande vantagem para a Odontopediatria como a redução do tempo de cadeira do paciente infantil. O objetivo do presente trabalho foi relatar um caso onde foi aplicada a técnica da muralha de silicona em paciente pediátrico. Paciente M.E.D, gênero feminino, raça branca, 7 anos de idade, apresentando fratura oblíqua das coroas dos dentes 11 e 21. Após procedimentos emergenciais, a paciente teve suas arcadas moldadas, e posterior moldagem de gesso, reconstrução em cera, confecção da muralha e restauração dos dentes fraturados. O caso foi solucionado apenas com recursos de dentística, técnica da muralha, utilização de ceroplastia e resinas compostas fotopolimerizáveis, alcançando-se um bom resultado estético. Portanto, conclui-se que a confecção da técnica da muralha de silicona para restauração direta em dentes anteriores traz vantagens no tempo gasto para realização do procedimento clínico, além de resultado satisfatório e estético.

Metformin, commercialized under several trademarks and also as a generic medicine, is an oral anti-diabetic drug, belonging to the biguanide class. It is actually the first choice in the treatment of Type 2 diabetes mellitus (DM2) due to its toxicity and clinical efficaciousness. It extensive use requires a constant discussion on its characteristics and applications. Current paper is a bibliographical review comprising the application of metformin in DM2 treatment as its chemical, physical-chemical, pharmacokinetic, pharmacodynamics properties, its clinical usages, contraindications and side effects. Review occurred in Pubmed, Bireme, Lilacs and SciELO data banks and in research in journals published on the Brazilian Platform in Scientific Information and in books on the subject. Results show that metformin is the best medicine for diabetic patients, with auxiliary therapy for other physiological disorders. A metformina, medicamento comercializado por diversas marcas e também na forma de genérico, é um antidiabético oral pertencente à classe das biguanidas. Devido ao seu perfil de toxicidade e à sua eficácia clínica é a principal escolha no tratamento do diabetes mellitus tipo dois (DM2). Pelo seu grande uso é necessária uma discussão constante a respeito de suas características e aplicações. Objetivou-se realizar uma revisão bibliográfica, na qual serão abordadas a aplicação da metformina no tratamento de DM2 bem como suas propriedades químicas, físico-químicas, farmacocinéticas, farmacodinâmicas, seus usos clínicos, contraindicações e efeitos adversos. Revisão da literatura realizada nos bancos de dados Pubmed, Bireme, Lilacs e Scielo, bem como pesquisa nos periódicos do Portal Brasileiro da Informação Científica e livros sobre o assunto. Pelo exposto percebe-se que a metformina para pacientes diabéticos é considerada um fármaco ideal tendo ainda aplicações na terapêutica adjuvante de outros distúrbios fisiológicos.

Objective: evaluating the epidemiological profile of intensive users of a Psychosocial Care Center. Method: a quantitative descriptive study, of a document basis, in the records of people seen intensively in the period from May to July 2010 in the Psychosocial Assistance Center in Regional Executive Secretary VI in Fortaleza-Ceara. Data were analyzed in IBM SPSS Statistics 20 presented in tables. The research project was approved by the Research Ethics Committee, Opinion nº 10029576-2. Results: there were analyzed 35 medical records of intensive patients, observing that females predominated, with low education and income. Among the complaints of symptoms predominated auditory hallucinations, regarding the diseases predominated mood disorder. Conclusion: the public policies of mental health in Fortaleza should act to meeting the needs of changes in CAPS. Objetivo: avaliar o perfil epidemiológico dos usuários intensivos de um Centro de Atenção Psicossocial. Método: estudo descritivo quantitativo, de base documental, nos prontuários de pessoas atendidas de forma intensiva no período de maio a julho de 2010 no Centro de Assistência Psicossocial da Secretaria Executiva Regional VI do município de Fortaleza-Ceará. Os dados foram analisados no Programa IBM SPSS Statistics 20 apresentados em tabelas. O projeto de pesquisa foi aprovado pelo Comitê de Ética em Pesquisa, Parecer de nº 10029576-2. Resultados: foram analisados 35 prontuários de pacientes intensivos, observou-se que o gênero feminino predominou, principalmente de escolaridade e renda baixas. Entre as queixas de sintomatologia predominaram as alucinações auditivas, quanto às patologias predominou o transtorno de humor. Conclusão: as políticas públicas de saúde mental de Fortaleza devem atuar no sentido de atender as necessidades de mudanças no CAPS. Objetivo: evaluar el perfil epidemiológico de los usuarios intensivos de un Centro de Atención Psicosocial. Método: un estudio descriptivo cuantitativo, de base de documental, en los registros de personas atendidas intensamente en el período mayo-julio, 2010, en el Centro de Asistencia Psicosocial de la Secretaria Ejecutiva Regional VI en Fortaleza-Ceará. Se analizaron los datos en IBM SPSS Statistics 20 presentados en tablas. El proyecto de investigación fue aprobado por el Comité de Ética en la Investigación, Opinión nº 10029576-2. Resultados: eran analizados 35 prontuarios de pacientes intensivos, se observó que las mujeres predominaban, principalmente de baja educación y bajos ingresos. Entre los síntomas de quejas predominan las alucinaciones auditivas, para las enfermedades predominó el trastorno de humor. Conclusión: las políticas públicas de salud mental de Fortaleza deben actuar para satisfacer las necesidades de cambios en el CAPS.

Type 2 diabetes mellitus (DM2 is a syndrome which may be defined as a condition of heterogeneous metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and action, or both. Metformin is the drug of choice for the treatment of type 2 diabetes, and it is the oral antihyperglyciemic most widely prescribed, due to their favorable toxicity profile and efficacy. Bioavailability studies have several functions including assessment of drugs bioequivalence, evaluation of drugs with new active principles and evaluating new formulations. This study aimed to assess the bioavailability of a formulation of metformin hydrochloride 850 mg film coated tablets, called test formulation, versus a reference formulation in the national market with the same dose of the drug in healthy volunteers of both genders. This is a clinical trial open-type, randomized, crossed, two-period, two-sequence, in which the volunteers received in each distinct period of 01 film coated tablet formulation of 01 test or reference formulation. The formulations were administered in a single oral dose, followed by blood sampling, at least four half-lives of study drug. The treatment periods obeyed an interval of seven half-lives, between them (washout). The metformin plasma concentrations were measured by a specific and validated analytical method based on high efficiency liquid chromatography coupled to mass spectrometry (HELC / MS). The data from this study reveal that the test formulation and the reference formulation showed similar results within the variation limits provided in the regulator norms (80-125%) for AUCinf (area under the curve) and Cmax (maximum serum concentration of drug). Thus, it will be possible ensure interchangeability between the formulations, which could lead to market competition and therefore more competitive prices and easy access to the drug. O diabetes mellitus tipo 2 (DM2) é uma síndrome que pode ser definida como uma condição de distúrbios metabólicos heterogêneos caracterizados por hiperglicemia resultante de defeitos na secreção e ação da insulina, ou ambos. A metformina é o fármaco de primeira escolha para tratamento de DM2, sendo o anti-hiperglicemiante oral mais amplamente prescrito, devido ao seu perfil de toxicidade reduzida e eficácia clínica. Os estudos de biodisponibilidade apresentam diversas funções, entres elas podem-se listar: avaliação da bioequivalência de medicamentos, avaliação de medicamentos com princípios ativos novos e avaliação de novas formulações. Este estudo teve o objetivo de avaliar a biodisponibilidade entre uma formulação de cloridrato de metformina 850 mg em comprimidos revestidos, chamada formulação teste, versus uma formulação de referência no mercado nacional com a mesma dose do fármaco e mesma forma farmacêutica, em voluntários sadios de ambos os sexos. Trata-se de um ensaio clínico do tipo aberto, randomizado, cruzado, com dois períodos, duas sequências, nos quais os voluntários receberam em cada período distinto, 01 comprimido revestido da formulação teste ou 01 da formulação de referência. As formulações foram administradas em dose única, via oral, seguida de coletas de sangue, de pelo menos quatro meias-vidas do fármaco em estudo. Os períodos de tratamento obedeceram a um intervalo de sete meias-vidas, entre eles (washout). As concentrações plasmáticas de metformina foram dosadas por método analítico específico e validado, baseado em cromatografia líquida de alta eficiência acoplada à espectrometria de massa (CLAE/EM). Os dados deste estudo revelaram que a formulação teste e a formulação referência apresentaram resultados equivalentes, dentro dos limites de variação previstos nas normativas reguladoras (80-125%) para os parâmetros ASCinf (área sob a curva) e Cmax (concentração sérica máxima do fármaco). Desse modo, será possível garantir uma intercambialidade entre as formulações, que poderá gerar competição no mercado e consequentemente preços mais competitivos e facilidade de acesso ao medicamento.