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The DF-4 defibrillator standard has been rapidly adopted due to its convenience at implantation. There are however trade-offs compared to the traditional DF-1 standard that are underappreciated. This viewpoint outlines the advantages and limitations of current defibrillator lead standards that should be kept in mind, as they impact the options that are available to deal with issues that may arise. [ABSTRACT FROM AUTHOR]

Almost all activities in all sectors are supported by technology and information. Fintech has attracted much attention, but the current use of Fintech is still in doubt. This study aims specifically to determine the specific benefits that are felt as well as the negative impacts arising from the use of Fintech together can influence the use of Fintech repeatedly, specifically for the younger generation. This type of research is quantitative research. The sampling method used is Quota Sampling. In this study, 20 samples will be taken from several universities in Malang. Based on the results of the research and discussion of this study, it can be concluded that the higher the economic benefits and comfort provided by Fintech, the higher the recurring assistance for Fintech. Financial risk (financial influence) as a moderating variable that influences the effect of economic benefits (economic benefits) on the continuation of financial technology intentions (intention to use repeatedly in financial technology products). The financial risk offered by Fintech means the higher interest in using Fintech because of the higher the level of Fintech usage the higher.

Inhaled corticosteroid (ICS)-containing therapies are the mainstay of pharmacological management of asthma. They can be administered alone or in combination with a long-acting bronchodilator, depending on asthma severity, and may also be supplemented with short-acting bronchodilators for as-needed rescue medication. Adherence to asthma therapies is generally poor and characterized by underuse of ICS therapies and over-reliance on short-acting bronchodilators, which leads to poor clinical outcomes. This article reviews efficacy versus systemic activity profiles for various dosing regimens of budesonide (BUD) and fluticasone propionate (FP). We performed a structured literature review of BUD and FP regular daily dosing, and BUD/formoterol (FOR) as-needed dosing, to explore the relationship between various dosing patterns of ICS regimens and the risk–benefit profile in terms of the extent of bronchoprotection and cortisol suppression. In addition, we explored how adherence could potentially affect the risk–benefit profile, in patients with mild, moderate, and moderate-to-severe asthma. With a specific focus on BUD or FP-containing treatments, we found that regular daily ICS and ICS/long-acting β2-agonist (LABA) dosing had a greater degree of bronchoprotection than as-needed BUD/FOR dosing or BUD/FOR maintenance and reliever therapy (MART) dosing, and still maintained low systemic activity. We also found that the benefits of regular daily ICS dosing regimens were diminished when adherence was low (50%); the shorter duration of bronchoprotection observed was similar to that seen with typical as-needed BUD/FOR usage. These findings have implications for aiding clinicians with selecting the most suitable treatment option for asthma management, and subsequent implications for the advice clinicians give their patients. Plain Language Summary: Inhaled corticosteroid (ICS)-containing therapies can be administered in a variety of ways depending on a patient's asthma severity. Patients with mild asthma tend to experience symptom relief with as-needed or regular daily use of an ICS alone, whereas patients with more severe asthma may require regular daily use of an ICS plus a long-acting β2-agonist (LABA) to experience sufficient asthma control. However, failure to correctly adhere to ICS-containing therapies or an over-reliance on short-acting bronchodilators for symptom relief hinders optimal asthma management, thus negatively affecting overall patient health and wellbeing. Understanding how different dosing regimens affect the degree of bronchoprotection (efficacy) and cortisol suppression (systemic activity) of ICS treatments would benefit physicians by helping them to prescribe the most appropriate treatment for their patient's asthma. We performed a structured literature review of two ICS molecules—budesonide (BUD) (alone and combined with formoterol [FOR]) and fluticasone propionate (FP)—to explore the relationship between various ICS dosing regimens, and then used these findings to construct models for ICS risk–benefit profiles. Our models factored in different ICS dosing regimens—as-needed, regular daily dosing, and maintenance and reliever therapy (MART)—and various degrees of treatment adherence. We found that regular daily ICS and ICS/LABA dosing provided better bronchoprotection than as-needed BUD/FOR dosing or BUD/FOR MART dosing, but this benefit was diminished with low adherence. Regular daily dosing maintained low cortisol suppression, which indicated a fairly low risk of negative side effects. Our findings have subsequent implications for optimizing treatment in patients with asthma. [ABSTRACT FROM AUTHOR]

Bisphosphonates (BPs) are the most commonly used medications for osteoporosis. This ASBMR report provides guidance on BP therapy duration with a risk-benefit perspective. Two trials provided evidence for long-term BP use. In the Fracture Intervention Trial Long-term Extension (FLEX), postmenopausal women receiving alendronate for 10 years had fewer clinical vertebral fractures than those switched to placebo after 5 years. In the HORIZON extension, women who received 6 annual infusions of zoledronic acid had fewer morphometric vertebral fractures compared with those switched to placebo after 3 years. Low hip T-score, between -2 and -2.5 in FLEX and below -2.5 in HORIZON extension, predicted a beneficial response to continued therapy. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women at high risk, for example, older women, those with a low hip T-score or high fracture risk score, those with previous major osteoporotic fracture, or who fracture on therapy, continuation of treatment for up to 10 years (oral) or 6 years (intravenous), with periodic evaluation, should be considered. The risk of atypical femoral fracture, but not osteonecrosis of the jaw, clearly increases with BP therapy duration, but such rare events are outweighed by vertebral fracture risk reduction in high-risk patients. For women not at high fracture risk after 3 to 5 years of BP treatment, a drug holiday of 2 to 3 years can be considered. The suggested approach for long-term BP use is based on limited evidence, only for vertebral fracture reduction, in mostly white postmenopausal women, and does not replace the need for clinical judgment. It may be applicable to men and patients with glucocorticoid-induced osteoporosis, with some adaptations. It is unlikely that future trials will provide data for formulating definitive recommendations. © 2015 American Society for Bone and Mineral Research.

Study Design: Retrospective review of a prospectively enrolled multicenter Adult Spinal Deformity (ASD) database.Objective: Investigate invasiveness and outcomes of ASD surgery by frailty state.Summary Of Background Data: The ASD Invasiveness Index incorporates deformity-specific components to assess correction magnitude. Intersections of invasiveness, surgical outcomes, and frailty state are understudied.Methods: ASD patients with baseline and 3-year (3Y) data were included. Logistic regression analyzed the relationship between increasing invasiveness and major complications or reoperations and meeting minimal clinically important differences (MCID) for health-related quality-of-life measures at 3Y. Decision tree analysis assessed invasiveness risk-benefit cutoff points, above which experiencing complications or reoperations and not reaching MCID were higher. Significance was set to P < 0.05.Results: Overall, 195 of 322 patients were included. Baseline demographics: age 59.9 ± 14.4, 75% female, BMI 27.8 ± 6.2, mean Charlson Comorbidity Index: 1.7 ± 1.7. Surgical information: 61% osteotomy, 52% decompression, 11.0 ± 4.1 levels fused. There were 98 not frail (NF), 65 frail (F), and 30 severely frail (SF) patients. Relationships were found between increasing invasiveness and experiencing a major complication or reoperation for the entire cohort and by frailty group (all P < 0.05). Defining a favorable outcome as no major complications or reoperation and meeting MCID in any health-related quality of life at 3Y established an invasiveness cutoff of 63.9. Patients below this threshold were 1.8[1.38-2.35] (P < 0.001) times more likely to achieve favorable outcome. For NF patients, the cutoff was 79.3 (2.11[1.39-3.20] (P < 0.001), 111 for F (2.62 [1.70-4.06] (P < 0.001), and 53.3 for SF (2.35[0.78-7.13] (P = 0.13).Conclusion: Increasing invasiveness is associated with increased odds of major complications and reoperations. Risk-benefit cutoffs for successful outcomes were 79.3 for NF, 111 for F, and 53.3 for SF patients. Above these, increasing invasiveness has increasing risk of major complications or reoperations and not meeting MCID at 3Y.Level of Evidence: 3. [ABSTRACT FROM AUTHOR]

The research conducted to estimate the potential economic benefit from adoption of drought tolerant soybean (Glycine max (L.) Merr.) variety NRC-7 in Indore district of Madhya Pradesh, where majority of area is under rainfed system. In this study, the potential economic benefit in terms of economic surplus and risk reduction was estimated for NRC-7 and alternative varieties, JS-93-05 and JS 95-60. NRC-7 requires less cost of cultivation compared to other two varieties, and withstands stress condition. In normal condition, the economic surplus for NRC-7 was ₹ 686 million per year, and that of, JS-93-05 and JS 95-60 is about ₹ 3161 million, ₹ 6291 million, respectively. For NRC-7, the risk reduction benefit was to the level of ₹ 547 million, which accounted for about 83.8% of total benefits for that variety. On per ha basis, NRC 7 performs well over the other two varieties in reducing the fluctuation in income of farmers. So there is a need to develop and increase the awareness of abiotic stress tolerant varieties to cope up with the income fluctuation due to weather risks.

The aim was (1) to perform an up-to-date systematic review of the male circumcision (MC) literature and (2) to determine the number of adverse medical conditions prevented by early MC in Australia. Searches of PubMed using “circumcision” with 39 keywords and bibliography searches yielded 278 publications meeting our inclusion criteria. Early MC provides immediate and lifetime benefits, including protection against: urinary tract infections, phimosis, inflammatory skin conditions, inferior penile hygiene, candidiasis, various STIs, and penile and prostate cancer. In female partners MC reduces risk of STIs and cervical cancer. A risk-benefit analysis found benefits exceeded procedural risks, which are predominantly minor, by approximately 200 to 1. It was estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime. An increase in early MC in Australia to mid-1950s prevalence of 85% from the current level of 18.75% would avoid 77,000 cases of infections and other adverse medical conditions over the lifetime for each annual birth cohort. Survey data, physiological measurements, and the anatomical location of penile sensory receptors responsible for sexual sensation indicate that MC has no detrimental effect on sexual function, sensitivity or pleasure. US studies found that early infant MC is cost saving. Evidence-based reviews by the AAP and CDC support early MC as a desirable public health measure. Although MC can be performed at any age, early MC maximizes benefits and minimises procedural risks. Parents should routinely be provided with accurate, up-to-date evidence-based information in an unbiased manner early in a pregnancy so that they have time to weigh benefits and risks of early MC and make an informed decision should they have a son. Parental choice should be respected. A well-trained competent practitioner is essential and local anaesthesia should be routinely used. Third party coverage of costs is advocated.

The DF-4 defibrillator standard has been rapidly adopted due to its convenience at implantation. There are however trade-offs compared to the traditional DF-1 standard that are underappreciated. This viewpoint outlines the advantages and limitations of current defibrillator lead standards that should be kept in mind, as they impact the options that are available to deal with issues that may arise., Competing Interests: Conflict of interest: C.S. has received speaker honoraria, consulting fees or institutional fellowship/research support from Biosense Webster, Biotronik, Boston Scientific, Medtronic, and Microport. K.A.E. has received speaker honoraria, consulting and research support from Medtronic and Boston Scientific, and consulting fees from Biotronik and Abbott. H.B. has received speaker honoraria, consulting fees or institutional fellowship/research support from Abbot, Biotronik, Boston Scientific, Medtronic, and Microport., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Finding an appropriate way to improve the investment comprehensive benefits for on-line monitoring is a new issue for power industry. In this paper, a priority assessment model for transformer on-line monitoring is proposed. The assessment model consists of device level and system level. The device level is divided into property assessment and operation assessment. The details of various assessment methods were described in the following sections, including device property assessment based on fuzzy analytic hierarchy process (FAHP), operation condition assessment method based on condition assessment technology and system level assessment method based on risk benefits index. An actual grid is utilized to validate the model and the numerical results illustrate that: the proposed assessment model can provide an appropriate on-line monitoring investment order for transformers. It also verifies that considering multiple aspects related to the target problem could give a more comprehensive assessment result than just considering just one or two of them. This paper provides a feasible solution to achieve more investment benefits for transformer online monitoring, which can provide on-line monitoring investment references for power industry. [ABSTRACT FROM AUTHOR]

SummarySodium valproate and related preparations have recently undergone regulatory review following concern about effects on the unborn child and doctors' failure to communicate risk. The issues are wider. Valproate is overused in psychiatry based on the false perception that 'ease' of use equates to better safety than alternatives. Valproic acid can disrupt fundamental physiological processes, the consequences of which are poorly understood and little discussed in the psychiatric literature. Valproate may be useful in a small number of patients with bipolar disorder but current prescribing patterns are unjustified. Perception needs to change.Declaration of interestD.C.O. is psychiatric commissioner on the Commission on Human Medicines and a member of the European Medicines Agency's Scientific Advisory Group on Psychiatry. He chaired the European Medicines Agency's review of the psychiatric use of valproate in pregnancy and women of childbearing potential. [ABSTRACT FROM AUTHOR]

Bipolar disorder is a common psychiatric illness with lifetime prevalence of about 1% and up to 4% if defined by the concept of bipolar spectrum. Depression is the most difficult to treat and the most frequent state of the bipolar disorder. Bipolar depression is also probably underdiagnosed because of the limited criteria of previous hypomanic or manic episode. Antidepressants are the most common treatment prescribed in bipolar depression but their use in this context remains controversial. Objective: The aim of this article is to review literature and guidelines in order to help psychiatrists in their decision to prescribe or not an antidepressant agent in bipolar depression. Method: The author conducted a computerized literature search of the Medline and ScienceDirect databases to identify studies involving antidepressants use in bipolar disorder through 2015. Results: Use of the antidepressants in bipolar depression in clinical practice is very large, mostly in combination with a mood stabilizer. The single use of a mood stabilizer agent is rare. Most of type 1 bipolar depressions are treated with an antidepressant in association, but the use of monotherapy is not uncommon in type 2 bipolar depression. Since the 2000's their widespread use remains (even if monotherapy is declining compared to combination with mood stabilizers). This fact can be explained by the difficulties to diagnose a bipolar depression without any history of previous manic episode. In this aim, many authors have tried to define the bipolar spectrum. Early start of the disease, family history of bipolar disorder, hyperthymic temperament, atypical depression and more than 4 previous episodes have to be considered in clinical evaluation. The risks of the use of antidepressants in bipolar disorder are now better known: Mood switch, rapid cycle, treatment-resistance, Antidepressant-associated Chronic Irritable Dysphoria, and activation syndrome. The significant use of antidepressant in bipolar depression could be explained by diagnoses difficulties and divergent findings in literature. The authors highlight the lack of strong comparative studies assessing respective efficacy between antidepressants and efficacy versus addition of a mood stabilizer concerning this important public health question. Conclusion: The prescription of an antidepressant is a matter of the clinical and pharmacological expertise of the psychiatrist. First, he has to be above in the reassurance of his prescription if he decides to prescribe an antidepressant in bipolar depression. [ABSTRACT FROM AUTHOR]

Risky behaviours among young people are relatively frequent, with several motives and attitudes lying behind. Our objective was to evaluate the role of risk perception, attractiveness and motives for risk behaviour taking among university students in Lebanon. A cross-sectional study was carried out using a proportionate cluster sample of Lebanese students in public and private universities. Items of risk intake and perception scale, attractiveness of risky behaviours, and motives for risky behaviours were assessed, in addition to cigarette and waterpipe smoking and dependence, alcohol problematic consumption and mental distress scale. After verifying the validity of scales and reliability in the university students' population, we found that risk perception was associated with lower risk intake, while risk attractiveness was a driver for it. Moreover, motives differed in their driving of risky behaviour, a particular point was that women indicated more goal achievement objectives, the latter concept was associated with lower risk taking. University students in Lebanon, women in particular, demonstrated wiser behaviour and may benefit from heath education programme to increase their awareness about risky behaviours. Identifying other personal, environmental, social and psychological predictors may also be important to improve effectiveness of these programmes. [ABSTRACT FROM PUBLISHER]

High dose thyroid hormone has been in use since the 1930s for the treatment of affective disorders. Despite numerous papers showing benefit, the lack of negative trials and its inclusion in multiple treatment guidelines, high dose thyroid has yet to find wide spread use. The major objection to the use of high dose thyroid is the myth that it causes osteoporosis. This paper reviews the literature surrounding the use of high dose thyroid, both in endocrinology and in psychiatry. High dose thyroid does not appear to be a significant risk factor for osteoporosis while other widely employed psychiatric medications do pose a risk. Psychiatrists are uniquely qualified to do the risk-benefit analyses of high dose thyroid for the treatment of the bipolar I, bipolar II and bipolar NOS. Other specialties do not have the requisite knowledge of the risks of alterative medications or of the mortality and morbidity of the bipolar disorders to do a full risk benefit analysis. [ABSTRACT FROM AUTHOR]

The US Preventive Services Task Force recently promulgated revised guidelines for screening mammography. Criticisms were related to the undervaluation of future lives saved and the overvaluation of negative impacts of mammography. Radiologists downplayed quality-of-life factors, potentially understating the value of all imaging procedures. The task force''s recommendations for core needle biopsy, based on similar conceptual frameworks, were not met with equivalent responses. Full appreciation of the costs and benefits of screening provides the basis for making the best decisions for individuals and populations. This is undermined by the mixed messages that patients and physicians receive during clinical encounters and through other means. Quantitative approaches to medical care are valid on their own terms and when evaluated in the individual context. Insights from behavioral economics and political science inform discussion of population-based medical interventions. Preventing harm from medical interventions satisfies both the “primum non nocere” dictum and the loss aversion heuristic concordantly. The most effective medical care is provided when benefits are maximized and complications are minimized, especially when the harms occur immediately and the benefits are delayed. The importance of both quality of life and longevity in health care decision making require minimizing negative impacts of mammography when screening low-risk populations. Current practice differs significantly from the successful randomized trials, front-loading costs of false-positive examinations, and overtreatment. By decreasing false-positive mammographic results through adherence to ACR BI-RADS® recommendations, radiologists can answer critics of early and frequent screening while still reducing cancer deaths. [Copyright &y& Elsevier]

The aim was (1) to perform an up-to-date systematic review of the male circumcision (MC) literature and (2) to determine the number of adverse medical conditions prevented by early MC in Australia. Searches of PubMed using "circumcision" with 39 keywords and bibliography searches yielded 278 publications meeting our inclusion criteria. Early MC provides immediate and lifetime benefits, including protection against: urinary tract infections, phimosis, inflammatory skin conditions, inferior penile hygiene, candidiasis, various STIs, and penile and prostate cancer. In female partners MC reduces risk of STIs and cervical cancer. A risk-benefit analysis found benefits exceeded procedural risks, which are predominantly minor, by approximately 200 to 1. It was estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime. An increase in early MC in Australia to mid-1950s prevalence of 85% from the current level of 18.75% would avoid 77,000 cases of infections and other adverse medical conditions over the lifetime for each annual birth cohort. Survey data, physiological measurements, and the anatomical location of penile sensory receptors responsible for sexual sensation indicate that MC has no detrimental effect on sexual function, sensitivity or pleasure. US studies found that early infant MC is cost saving. Evidence-based reviews by the AAP and CDC support early MC as a desirable public health measure. Although MC can be performed at any age, early MC maximizes benefits and minimises procedural risks. Parents should routinely be provided with accurate, up-to-date evidence-based information in an unbiased manner early in a pregnancy so that they have time to weigh benefits and risks of early MC and make an informed decision should they have a son. Parental choice should be respected. A well-trained competent practitioner is essential and local anaesthesia should be routinely used. Third party coverage of costs is advocated., Competing Interests: Conflict of interest BJM is a Member of the Editorial Board of Journal of Men’s Health. MH is medical director of Quick Medical Pty Ltd, a company that markets medical devices, including circumcision devices, in Australia. All authors are Members of the Circumcision Academy of Australia, a not-for-profit, government registered, medical society that provides accurate, evidence-based information on male circumcision to parents, practitioners and others, as well as contact details of doctors who perform the procedure in Australia and New Zealand; PK is President, BJM is Secretary, NB is Treasurer and MH is Surgical Training Co-ordinator of this organization.

The aim of our study was to describe the balance between health benefits and risks associated with the consumption of crawfish and nine fish species from lake Trasimeno. We thus determined both fatty acid profiles (particularly, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids) and chemical pollutants (some polychlorinated biphenyls, pesticides, and heavy metals) in fish muscle tissues. The contents of all fatty acids varied significantly among species. Sand smelt, carp, and tench, which have a high fat content, contained considerable amounts of EPA and DHA; lean fish, like perch, pike, and largemouth bass, which have relatively high percentages of the predominant n-3 fatty acids EPA and DHA, showed lower amounts of these fatty acids because of their low lipid contents. Some species contributed strongly to the Dietary Reference Intake (RDI) of EPA and DHA. The contribution of lean fish to the RDI of EPA and DHA was more limited. The concentrations of all contaminants in fish muscle tissues were lower than the regulatory limits, demonstrating the safety of the environmental conditions of the lake. The contribution to health-based reference values and benefit-risk quotients indicated that the health benefits of consumption of fish from lake Trasimeno outweigh the potential risks.

Clinical reasoning in medicine describes the process whereby a clinician gathers, assimilates, and assesses information about a person and their illness to assign a diagnosis and institute therapy. Care of patients in the intensive care unit involves managing a substantial quantity of incomplete, novel, and rapidly changing data. A modified nine-step bayesian approach to clinical reasoning comports well with this complex environment and is useful for assisting and educating novice learners to apply clinical reasoning accurately and consistently. When combined with a sophisticated approach to risk-benefit analysis to modify the treatment threshold, it becomes a useful and insightful tool for clinicians and those working in medical education., (Copyright © 2015 Elsevier Inc. All rights reserved.)