1. Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy
- Author
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Silvio Aime, Riccardo Rolle, Laura Conti, Francesca Arena, Chiara Callari, Francesco De Rose, Lorena Consolino, Dario Livio Longo, and Rachele Stefania
- Subjects
tumors ,Diagnostic Imaging ,vasculature ,Biomedical Engineering ,Pharmaceutical Science ,Photoacoustic imaging in biomedicine ,photoacoustic ,02 engineering and technology ,010402 general chemistry ,Tumor vasculature ,01 natural sciences ,Biomaterials ,Melanin ,Photoacoustic Techniques ,Experimental ,angiogenesis ,Mice ,Animals ,DCE ,skin and connective tissue diseases ,Neovascularization ,Pathologic ,Melanins ,Neovascularization, Pathologic ,Chemistry ,Mammary Neoplasms ,Antiangiogenic therapy ,Mammary Neoplasms, Experimental ,021001 nanoscience & nanotechnology ,optoacoustic ,melanin ,0104 chemical sciences ,Dynamic contrast ,Water soluble ,Permeability (electromagnetism) ,Biophysics ,nanoparticles ,Female ,dynamic contrast enhanced ,3003 ,sense organs ,0210 nano-technology - Abstract
A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.
- Published
- 2016