Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Authors :: Silvio Aime
Riccardo Rolle
Laura Conti
Francesca Arena
Chiara Callari
Francesco De Rose
Lorena Consolino
Dario Livio Longo
Rachele Stefania
Source :: Advanced healthcare materials, 6 (2017). doi:10.1002/adhm.201600550, info:cnr-pdr/source/autori:Longo, Dario L.; Stefania, Rachele; Callari, Chiara; De Rose, Francesco; Rolle, Riccardo; Conti, Laura; Consolino, Lorena; Arena, Francesca; Aime, Silvio/titolo:Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy/doi:10.1002%2Fadhm.201600550/rivista:Advanced healthcare materials (Print)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Publication Year :: 2016
Abstract: A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

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