198 results on '"Rheumatic pain"'
Search Results
2. Behavior to Overcome Rheumatic Pain in the Elderly.
- Author
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Mustika, I. Wayan and Mas Pratiwi, Ni Putu Indah
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OLDER people ,DEMOGRAPHIC characteristics ,NONPROBABILITY sampling ,AUTOIMMUNE diseases ,BEHAVIORAL research - Abstract
Rheumatism is an autoimmune disease in which the joints experience inflammation, resulting in swelling, pain and often causes damage to the inside of the joints. The high incidence of rheumatism in the elderly is due to the demographic characteristics of the elderly and their behavior in dealing with rheumatic pain is not maximal. The purpose of this study is to describe the behavior of dealing with rheumatic pain in the elderly in Mengwitani Village, Mengwi District, Badung Regency in 2021. This research is a descriptive study using a cross sectional approach. The sampling method in this study is to use non-probability sampling with consecutive sampling. The research was conducted in January - April 2021 in Mengwitani Village with a total sample of 66 respondents. The results of this study, in terms of the characteristics of the respondents, found that the most age suffered from rheumatic pain was 60-74 years, 50 respondents (75.8%), with the most gender being 43 respondents (65.2%), the most education was SD 53 respondents (80, 3%), and most jobs are traders 24 respondents (36.4%). Based on the results of the research on the behavior of dealing with rheumatic pain in the elderly, a small proportion of them had less knowledge as much as 8 respondents (12.1%), most of them had sufficient attitudes, namely 53 respondents (80.3%), and 24 respondents (36.4%) have actions that are classified as good in dealing with rheumatic pain. For the elderly it is recommended to make lifestyle changes so that they can reduce the risk of rheumatism. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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3. Management of pain in rheumatic diseases
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Neha Goyal, Mohit Goyal, and Vinod Ravindran
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Interventional pain procedures ,ozone therapy ,platelet-rich plasma therapy ,radiofrequency ablation ,rheumatic pain ,treatment ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Pain is often the presenting symptom of many rheumatic diseases, the predominant disabling symptom, the reason for frequent visits to the physician and a major cause of medical absenteeism, loss of work hours, and financial burden on the society. Pain in rheumatic diseases is now understood to be a result of interplay of inflammation, tissue damage, and neurogenic responses. Besides control of inflammation, the structural changes, central sensitization, and the associated issues of disturbances of sleep, mood, and cognition also need to be addressed. Apart from the useful addition of neuromodulators to our traditional repertoire of pain medications consisting of analgesics, nonsteroidal anti-inflammatory drugs, steroids, and opioids, there is a place for interventions in situations where pain persists even after reasonable control of widespread inflammation. These interventions are mostly percutaneous and have found applications in inflammatory, structural, as well as neurogenic pain. Interventional spine procedures, platelet-rich plasma therapy, ozone therapy, and radiofrequency ablation of neural structures have added new dimensions to the management of pain.
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- 2019
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4. Rheumatic Pain
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Morton, Debbie L., Jones, Anthony K. P., and Saba, Luca, editor
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- 2017
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5. Pain mechanisms for the practicing rheumatologist.
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Minhas D
- Subjects
- Humans, Rheumatologists psychology, Pain Management methods, Rheumatology, Pain Perception physiology, Catastrophization psychology, Central Nervous System Sensitization physiology, Chronic Pain physiopathology, Chronic Pain psychology, Rheumatic Diseases physiopathology, Rheumatic Diseases complications, Rheumatic Diseases psychology
- Abstract
Pain in rheumatic diseases transcends the traditional nociceptive paradigm, incorporating complex interactions between nociceptive, neuropathic, and nociplastic mechanisms, as well as significant psychosocial factors. Advances in understanding chronic pain highlight the role of peripheral and central sensitization, and the emergence of nociplastic pain-a result of altered central nervous system processing. This modern perspective acknowledges the influence of mood disorders, environmental stressors, and cognitive patterns like catastrophizing, revealing the intricate interplay between biological, psychological, and social determinants of pain. Research emphasizes the brain's pivotal role in pain perception, underscoring the importance of comprehensive approaches that integrate medical, psychological, and social interventions to address the multifaceted nature of chronic pain in rheumatic diseases effectively., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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6. Management of pain in rheumatic diseases.
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Goyal, Neha, Goyal, Mohit, and Ravindran, Vinod
- Abstract
Pain is often the presenting symptom of many rheumatic diseases, the predominant disabling symptom, the reason for frequent visits to the physician and a major cause of medical absenteeism, loss of work hours, and financial burden on the society. Pain in rheumatic diseases is now understood to be a result of interplay of inflammation, tissue damage, and neurogenic responses. Besides control of inflammation, the structural changes, central sensitization, and the associated issues of disturbances of sleep, mood, and cognition also need to be addressed. Apart from the useful addition of neuromodulators to our traditional repertoire of pain medications consisting of analgesics, nonsteroidal anti-inflammatory drugs, steroids, and opioids, there is a place for interventions in situations where pain persists even after reasonable control of widespread inflammation. These interventions are mostly percutaneous and have found applications in inflammatory, structural, as well as neurogenic pain. Interventional spine procedures, platelet-rich plasma therapy, ozone therapy, and radiofrequency ablation of neural structures have added new dimensions to the management of pain. [ABSTRACT FROM AUTHOR]
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- 2019
- Full Text
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7. Premilinary Phytochemical Study of Different Extracts of One Medicinal Plant Cissus quadrangularis
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K. S. Srinivasan and Saranya Arunagiri
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Ethanol extracts ,Antioxidant ,biology ,Phytochemical ,Traditional medicine ,medicine.medical_treatment ,medicine ,Rheumatic pain ,Cissus quadrangularis ,Vitaceae ,biology.organism_classification - Abstract
Herbal plants are the most valuable resources to prevent from many illness and to treat the many disorders in humans. Cissus quadrangularis is a one of the traditional medicine and belonging to vitaceae family. In Ayurvedha medicinal system this plant is used to treat many diseases like diabetes, snake bites, rheumatic pain, cardiovascular diseases. Cissus quadrangularis used as anticancer properties against MG63 human osteocarcinoma cells. Stem of the Cissus quadrangularis is an edible vegetable and the plant commonly called as ‘bone setter’. Our present study was analyzed the primary phyto constituents present the different solvents of Cissus quadrangularis and antioxidant activity. Three different extracts aqueous, methanol and ethanol were used to find out the phytoconstituents and antioxidant properties. The results were reveals that the plant Cissus quadrangularis consists of numerous primary and secondary phytoconstituents. Flavonoids and tannins were found to be higher in ethanol extracts, legnings, saponins was high in methanol extracts. Antioxidant study also reveals ethanol extracts shows more antioxidant activity than other two solvents.
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- 2021
8. Qualitative and Quantitative Analysis of Dexamethasone in Rheumatic Pain Herbal Medicine Using Thin-Layer Chromatography (TLC) – Densitometry
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Desy Ayu Irma Permatasari, Muladi Putra Mahardika, and Novita Kurniasri
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tlc-densitometric ,Traditional medicine ,business.industry ,dexamethasone ,RM1-950 ,rheumatic pain herbal medicine ,quantitave analysis, qualitative analysis ,Thin-layer chromatography ,Ingredient ,medicine ,Rheumatic pain ,Medicinal herbs ,Therapeutics. Pharmacology ,Densitometry ,business ,Quantitative analysis (chemistry) ,Dexamethasone ,medicine.drug - Abstract
Chemical medicine is chemical substances that is used as the main ingredient of chemical drugs. This compound is usually added to herbal medicine preparation to strengthen the indication of the traditional medicine.Chemical medicine was prohibited from being added to traditional medicinal preparations. But in reality, a lot of medicinal herbs could have contained medicinal chemicals on the market sale. This purpose of this research was to know the chemical contamination of the dexamethasone also the concentration contained in the rheumatic pain herbal medicine. This research was used three kind of rheumatic pain herbal medicine sample to identify dexamethasone, the sample code is S1, S2, and S3. The analysis of qualitative method are organoleptic test, FTIR characteristic test, TLC evaluation. The analysis of quantitative were purposed to know the dexamethasone concentration contained on the rheumatic pain herbal medicine using TLC-Densitometric method. The result show that the three sample of rheumathic pain herbal medicine were contaminated by dexamethasone chemical medicine. Based on organoleptic test, the results show color, smell, and taste. Characterization of the dexamethasone using FTIR were to know functional groups of dexamethasone contained in the rheumatic pain herbal medicine sample, the functional groups of the sample S1, S2, and S3 were compared to dexamethasone standard. To identify of TLC method, obtained Rf value of dexamethasone standard and the sample, visualizing a stain color purple-fluorescence on the UV 254 nm. The analysis of quantitative dexamethasone concentration using TLC-Densitometric showed the presence of dexamethasone in the sample for S1, S2 and S3. The concetration of dexamethasone obtained of sample S1, S2, S3 were 1014.64 µg/g ; 131.15 µg/g ; 135.54 µg/g respectively.
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- 2021
9. Diffusion-weighted imaging versus short tau inversion recovery sequence: Usefulness in detection of active sacroiliitis and early diagnosis of axial spondyloarthritis.
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Chan, Chiu Wai Shirley, Tsang, Helen Hoi Lun, Li, Philip Hei, Lee, Kam Ho, Lau, Chak Sing, Wong, Pui Yan Stella, and Chung, Ho Yin
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DIFFUSION , *TAU proteins , *SPONDYLOARTHROPATHIES , *BACKACHE , *RHEUMATOLOGY - Abstract
Objective: To compare the utility of Diffusion weighted imaging (DWI) with short tau inversion recovery (STIR) sequence in the diagnosis of early axial spondyloarthritis (SpA). Methods: Three hundred and five patients with chronic back pain were recruited consecutively from 3 rheumatology centers. Clinical, radiological and blood parameters were recorded. Patients with back pain duration no more than 3 years were classified as having early disease. STIR sequence and DWI of the sacroiliac joints were obtained and assessed using the Spondyloarthritis Research Consortium of Canada (SPARCC) method. The Assessment in Spondyloarthritis international Society definition was used to define positive STIR and DWI. Results were compared to expert diagnosed axial SpA. Results: When compared to STIR sequence, DWI had similar sensitivity (STIR 0.29, DWI 0.30) and specificity (STIR 0.97, DWI 0.92) in diagnosing sacroiliitis. However, STIR sequence had better reliability (STIR 0.78, DWI 0.61). In early disease group, DWI was not better than STIR sequence in detecting active sacroiliitis (sensitivity DWI vs STIR: 0.34 vs 0.36; specificity DWI vs STIR: 0.93 vs 0.93; positive predictive value DWI vs STIR: 0.92 vs 0.92; negative predictive value DWI vs STIR: 0.36 vs 0.37). Using the Assessment in SpondyloArthritis international Society (ASAS) classification criteria, 67/98 patients with early disease (sensitivity 0.91 specificity 0.90) and 221/305 overall (sensitivity 0.90; specificity 0.92) were classified as axial SpA. Among the expert diagnosed axial SpA patients who did not meet the ASAS criteria, only 2 had positive DWI. Conclusion: DWI and STIR have similar sensitivity in diagnosing axSpA in early disease. However, the use of DWI is limited by poorer reliability when compared with STIR. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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10. Plants used as painkiller in folk medicine in Turkey - III: Rheumatic pain.
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Erbay, Meryem Şeyda, Anıl, Sezin, and Melikoğlu, Gülay
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RHEUMATISM treatment , *ANALGESICS , *MEDICINAL plants - Abstract
There are many plants used by the public in the treatment of various diseases in Turkey. The folk remedies prepared with these plants from which treatment and how they used have been reached to day-to-day by transferring the generations. The traditional treatment methods are recorded by ethnobotanical researches and it is aimed to contribute to drug development studies. In this study, which was prepared by screening of ethnobotanical researches, 72 taxa which used in traditional treatment against rheumatic pain in Turkey are reached and the scientific and local names, families, used parts of these taxa and the use forms in rheumatic pain were compiled. According to the research done, families that are commonly used for rheumatic pain are Ranunculaceae (8 taxa), Asteraceae (5 taxa), Brassicaceae (5 taxa), Lamiaceae (5 taxa), Apiaceae (4 taxa) and Liliaceae (4 taxa). The plants used for rheumatic pain contain analgesic, anti-inflammatory, antiseptic and rubefian compounds. Rubefian compound containing species are applied externally to the rheumatoid region and act by increasing the blood supply of the region. Analgesic, anti-inflammatory and antiseptic active species are used in the form of decoction / infusion both internally and externally. [ABSTRACT FROM AUTHOR]
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- 2018
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11. The Complementary Health Approaches for Pain Survey (CHAPS): Validity testing and characteristics of a rural population with pain.
- Author
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Feinberg, Termeh, Jones, Dina L., Lilly, Christa, Umer, Amna, and Innes, Kim
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PAIN management , *RURAL population , *HEALTH surveys , *RHEUMATOLOGY , *DATA analysis - Abstract
Objectives: Little is known about patterns and correlates of Complementary Health Approaches (CHAs) in chronic pain populations, particularly in rural, underserved communities. This article details the development and implementation of a new survey instrument designed to address this gap, the Complementary Health Approaches for Pain Survey (CHAPS). Design: Following pilot-testing using pre-specified criteria to assess quality and comprehension in our target population, and after feedback regarding face-validity from content experts and stakeholders, the final cross-sectional self-report survey required 10–12 minutes to complete. It contained 69 demographic, lifestyle and health-related factors, and utilized a Transtheoretical Model (TTM) underpinning to assess short- and long-term use of 12 CHAs for pain management. Twenty additional items on pain severity, feelings, clinical outcomes, and activities were assessed using the Short-Form Global Pain Scale (SF-GPS); Internal reliability was assessed using Cronbach’s alpha. Settings/location: Investigators conducted consecutive sampling in four West Virginia pain management and rheumatology practices. Participants: 301 Appalachian adult patients seeking conventional care for pain management. Results: Response rates were high (88% ± 4.1%). High quality and comprehension deemed the CHAPS an appropriate measurement tool in a rural population with pain. Missing data were unrelated to patient characteristics. Participants predominantly experienced chronic pain (93%), had five or more health conditions (56%, Mean = 5.4±3.1), were white (92%), female (57%), and middle-aged (Mean = 55.6 (SD = 13.6) years). Over 40% were disabled (43%) and/or obese (44%, Mean BMI = 33.4±31.5). Additionally, 44% used opioids, 31% used other prescription medications, and 66% used at least one CHA for pain, with 48% using CHAs for greater than 6 months. There was high internal reliability of the SF-GPS (alpha = .93) and satisfactory internal reliability for each of the five TTM stages across (all) twelve CHAs: precontemplation (0.89), contemplation (0.72), preparation (0.75), action (0.70), and maintenance (0.70). Conclusions: The CHAPS is the first comprehensive measurement tool to assess CHA use specifically for pain management. Ease of administration in a population with pain support further use in population- and clinic-based studies in similar populations. [ABSTRACT FROM AUTHOR]
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- 2018
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12. Being aware of the painful body: Validation of the German Body Awareness Questionnaire and Body Responsiveness Questionnaire in patients with chronic pain.
- Author
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Cramer, Holger, Lauche, Romy, Daubenmier, Jennifer, Mehling, Wolf, Büssing, Arndt, Saha, Felix J., Dobos, Gustav, and Shields, Stephanie A.
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CHRONIC pain , *AWARENESS , *SELF-esteem , *MENTAL depression , *MINDFULNESS , *PUBLIC health - Abstract
Body awareness is an attentional focus on and awareness of internal body sensations. This study aimed to validate German versions of the Body Awareness Questionnaire (BAQ) and the Body Responsiveness Questionnaire (BRQ) in chronic pain patients and to assess their associations with pain-related variables and to assess their responsiveness to intervention. The instruments were translated to German and administered to 512 chronic pain patients (50.3±11.4 years, 91.6% female) to assess their factor structure and reliability. Cronbach’s α for the BAQ total score was 0.86. Factor analysis of the BRQ revealed the two factors Importance of Interoceptive Awareness (Cronbach’s α = 0.75) and Perceived Connection (Cronbach’s α = 0.75) and the single-item Suppression of Bodily Sensations. The BAQ was independently associated with lower mindfulness, self-esteem, stress, and depression; Importance of Interoceptive Awareness with mindfulness, self-acceptance, self-esteem, and physical contact; Perceived Connection with self-acceptance, vitality, and lower sensory pain; Suppression of Bodily Sensations with lower self-esteem, physical contact, and higher depressive symptoms. After a 10-week multimodal mind-body program (n = 202), the BAQ and Importance of Interoceptive Awareness increased and pain intensity and Suppression of Bodily Sensation decreased. In conclusion, body awareness and body responsiveness are associated with pain-related variables in patients with chronic pain. Mind-body interventions may positively influence both pain and body awareness, hinting at a potential mechanism of action of these interventions to be tested in further research. [ABSTRACT FROM AUTHOR]
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- 2018
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13. Pain Mechanisms in Patients with Rheumatic Diseases
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Deeba Minhas and Daniel J. Clauw
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,Central sensitization ,business.industry ,Chronic pain ,Peripheral Nervous System Diseases ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Nociception ,Rheumatology ,Rheumatic Diseases ,Internal medicine ,Mixed pain ,medicine ,Humans ,Rheumatic pain ,In patient ,Chronic Pain ,business ,030217 neurology & neurosurgery - Abstract
Patients with rheumatic diseases often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain.
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- 2021
14. Adaptación transcultural y validación de la metodología del Programa Orientado a la Comunidad para el Control de Enfermedades Reumáticas (COPCORD) en población indígena Wayuu. Venezuela
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Ingris Peláez Ballestas, Mery Evangelista Guerra, Ernesto García Mac Gregor, Nataly Beleño-Epieyu, Dexys Márquez, and Ysabel Granados
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Health personnel ,education.field_of_study ,Rheumatology ,Screening test ,business.industry ,Population ,Rheumatic pain ,Medicine ,Screening tool ,education ,business ,Humanities - Abstract
espanolObjetivo Adaptar transculturalmente y validar la metodologia COPCORD en poblacion indigena Wayuu del estado Zulia, Venezuela. Metodologia Se realizo un estudio de corte transversal en indigenas Wayuu de los municipios Mara y Guajira del estado Zulia, Venezuela, se adapto transculturalmente la version venezolana del cuestionario COPCORD y se tradujo del espanol venezolano al wayuunaiki (idioma Wayuu). Cien indigenas Wayuu aceptaron participar y se les administro el instrumento, casa por casa, por personal de salud bilingue capacitado. Los individuos COPCORD positivos fueron evaluados por reumatologos. Se realizo analisis descriptivo de variables, se midieron alfa de Cronbach, correlacion de Spearman, analisis de prueba de cribado (sensibilidad, especificidad, VPP y RVs+). Resultados El 66% fueron mujeres, edad promedio 41,4 anos, el 20% monolingues, el 21% analfabetos, el 69% unidos/casados, el 57% con trabajo informal. El 62% reportaron dolor, el 56% con criterios de enfermedades reumaticas; las mas frecuentes fueron: osteoartritis (32,3%), lumbalgia mecanica (13,9%) y sindrome doloroso regional reumatico (12,3%). Cinco dimensiones del instrumento presentaron alfa de Cronbach > 0,7. La sensibilidad fue del 100% y la especificidad del 11,1%, VPP 14,3%, RVs+ 1,13%. Conclusion El COPCORD es valido y util como herramienta de cribado para la deteccion de malestares musculoesqueleticos y enfermedades reumaticas en la poblacion indigena Wayuu. EnglishObjective To adapt cross-culturally and validate the COPCORD methodology in the indigenous Wayuu population of Zulia state, Venezuela. Methodology A cross-sectional study was conducted on Wayuu indigenous people from the Mara and Guajira municipalities of the state of Zulia, Venezuela. The Venezuelan version of the COPCORD questionnaire was transculturally adapted and translated from Venezuelan Spanish to Wayuunaiki (Wayuu language). One hundred indigenous Wayuu, agreed to participate, they were administered the instrument, house by house, by health personnel, who were bilingual and previously trained. Positive COPCORD individuals were evaluated by rheumatologists. A descriptive analysis of variables was performed, Cronbach's alpha was measured, Spearman's correlation, screening test analysis (sensitivity, specificity, VPP and SVR+). Results 66% were women, average age 41.4 years, 20% monolingual, 21% illiterate, 69% in a couple/married, 57% with informal work. Sixty-two percent reported pain, 56% with criteria of rheumatic diseases, the most frequent were: osteoarthritis (32.3%), mechanical lower back pain (13.9%), and regional rheumatic pain syndrome (12.3%). Five dimensions of the instrument presented Cronbach's alpha > 0.7. The sensitivity was 100% and specificity 11.1%, VPP 14.3%, SVR+ 1.13%. Conclusion The COPCORD is valid and useful as a screening tool for the detection of musculoskeletal complaints and rheumatic diseases in the indigenous Wayuu population.
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- 2021
15. Rheumaschmerz und chronischer Schmerz bei Kindern, Jugendlichen und jungen Erwachsenen
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A. Schramm, N. Draheim, M Georgi, Johannes-Peter Haas, and L. Höfel
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Gynecology ,medicine.medical_specialty ,Rheumatology ,business.industry ,medicine ,Chronic pain ,Rheumatic pain ,Early adolescents ,business ,medicine.disease - Abstract
Bei rheumatischen Erkrankungen wie der juvenilen idiopathischen Arthritis (JIA) tritt klassischerweise ein entzundungsbedingter Akutschmerz auf. Von chronischen Schmerzen spricht man ab einem Zeitraum von 3 Monaten. Schmerzen konnen sich trotz erfolgreicher Therapie als Schmerzerkrankung zu einem eigenstandigen Krankheitsbild entwickeln. Chronische Schmerzen und Schmerzerkrankungen konnen trotz guter Kontrolle der entzundlichen Aktivitat auch im Verlauf einer JIA entstehen. Es erfolgt die Darstellung moglicher Zusammenhange zwischen einer JIA und Schmerzerkrankungen. Neben einem Review der vorhandenen Literatur wurde eine retrospektive Kohortenstudie mit 906 Patienten mit chronischer Schmerzstorung mit somatischen und psychischen Faktoren (CSSPF) und/oder einem komplexen regionalen Schmerzsyndrom Typ I (CRPS I) durchgefuhrt und die Haufigkeit rheumatologischer Vorerkrankungen untersucht. Die JIA ist ein Risikofaktor fur die Entwicklung einer CSSPF. Vor allem die polyartikulare, die „extended“ oligoartikulare JIA, die Enthesitis-assoziierte JIA und die Psoriasisarthritis haben ein signifikant erhohtes Risiko. Dagegen finden sich die persistierende oligoartikulare und die systemische JIA nicht gehauft in der Vorgeschichte von Patienten mit einer CSSPF. Im Gegensatz dazu wurde kein nennenswert erhohtes Risiko fur die Entwicklung eines CRPS I beobachtet. Unsere Untersuchung zeigt, dass das Vorliegen einer JIA einen Risikofaktor nicht nur fur die Entstehung chronischer durch Fehlstellungen bzw. Arthrose bedingter Schmerzen, sondern auch einer chronischen Schmerzstorung darstellt. Weitere Untersuchungen sind notwendig, um zu klaren, welche Relevanz Krankheitsaktivitat und -dauer, aber auch psychologische Faktoren auf die Entstehung haben.
- Published
- 2021
16. Pain and pain mechanisms in patients with inflammatory arthritis: A Danish nationwide cross-sectional DANBIO registry survey.
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Rifbjerg-Madsen, S., Christensen, A. W., Christensen, R., Hetland, M. L., Bliddal, H., Kristensen, L. E., Danneskiold-Samsøe, B., and Amris, K.
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ARTHRITIS patients , *PAIN management , *CHRONIC pain , *INFLAMMATION , *CHARCOT joints , *DIAGNOSIS , *DISEASES , *PREVENTION - Abstract
Background: Central pain mechanisms may be prominent in subsets of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondyloarthritis (SpA). The painDETECT questionnaire (PDQ) identifies neuropathic pain features, which may act as a proxy for centrally mediated pain. The objectives were to quantify and characterize pain phenotypes (non-neuropathic vs. neuropathic features) among Danish arthritis patients using the PDQ, and to assess the association with on-going inflammation. Methods: The PDQ was included onto the DANBIO touch screens at 22 departments of Rheumatology in Denmark for six months. Clinical data and patient reported outcomes were obtained from DANBIO. A PDQ-score >18 indicated neuropathic pain features, 13–18 unclear pain mechanism and <13 non-neuropathic pain. Results: Pain data (visual analogue scale, VAS) was available for 15,978 patients. 7,054 patients completed the PDQ (RA: 3,826, PsA: 1,180, SpA: 1,093). 52% of all patients and 63% of PDQ-completers had VAS pain score ≥ 30 mm. The distribution of the PDQ classification-groups (<13/ 13-18/ >18) were; RA: 56%/24%/20%. PsA: 45%/ 27%/ 28%. SpA: 55% / 24%/ 21%. More patients with PsA had PDQ score >18 compared to RA and SpA (p<0.001). For PDQ > 18 significantly higher scores were found for all patient reported outcomes and disease activity scores. No clinical difference in CRP or swollen joint count was found. Logistic regression showed increased odds for having VAS pain ≥39 mm (the median) for a PDQ-score >18 compared to <13 (OR = 10.4; 95%CI 8.6–12.5). Conclusions: More than 50% of the Danish arthritis patients reported clinically significant pain. More than 20% of the PDQ-completers had indication of neuropathic pain features, which was related to a high pain-level. PDQ-score was associated with DAS28-CRP and VAS pain but not with indicators of peripheral inflammation (CRP and SJC). Thus, pain classification by PDQ may assist in mechanism-based pain treatment. [ABSTRACT FROM AUTHOR]
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- 2017
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17. Development and psychometric properties of knee-specific body-perception questionnaire in people with knee osteoarthritis: The Fremantle Knee Awareness Questionnaire.
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Nishigami, Tomohiko, Mibu, Akira, Tanaka, Katsuyoshi, Yamashita, Yuh, Yamada, Eiji, Wand, Benedict M., Catley, Mark J., Stanton, Tasha R., and Moseley, G. Lorimer
- Subjects
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OSTEOARTHRITIS diagnosis , *KNEE abnormalities , *KNEE pain , *DISABILITY identification , *LUMBAR pain , *DIAGNOSIS ,PAIN risk factors - Abstract
Background: Recent systematic reviews have demonstrated that pain associated with knee osteoarthritis (OA) is a complex phenomenon that involves various contributors. People with knee OA exhibit symptoms of impaired body-perception, including reduced tactile acuity, impairments in limb laterality recognition, and degraded proprioceptive acuity. The Fremantle Back Awareness Questionnaire (FreBAQ) was developed to assess body-perception specific to the back in people with chronic low back pain. The aim of this study was to develop and assess the psychometric properties of a knee-specific version of the FreBAQ-J (FreKAQ-J), determine whether people with knee pain experience perceptual impairments and investigate the relationship between disturbed self-perception and clinical status. Methods: Sixty-five people with knee OA completed the FreKAQ-J. A subset of the participants completed the FreKAQ-J again two-weeks later. Rasch analysis was used to assess item order, targeting, category ordering, unidimensionality, person fit, internal consistency, and differential item functioning. Validity was investigated by examining the relationship between the FreKAQ-J and clinical valuables. Results: The FreKAQ-J had acceptable internal consistency, unidimensionality, good test-retest reliability, and was functional on the category rating scale. The FreKAQ-J was significantly correlated with pain in motion, disability, pain-related catastrophizing, fear of movement, and anxiety symptomatology. Conclusions: We developed FreKAQ-J by modifying the FreBAQ-J. The FreKAQ-J fits the Rasch measurement model well and is suitable for use in people with knee OA. Altered body perception may be worth evaluating when managing people with knee OA. [ABSTRACT FROM AUTHOR]
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- 2017
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18. Estimation of years lived with disability due to noncommunicable diseases and injuries using a population-representative survey.
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Park, Ji In and Jung, Hae Hyuk
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DISABILITIES , *NON-communicable diseases , *WOUNDS & injuries , *OSTEOARTHRITIS , *BACKACHE - Abstract
The Global Burden of Disease 2010 and the WHO Global Health Estimates of years lived with disability (YLDs) uses disability-weights obtained from lay health-state descriptions, which cannot fully reflect different disease manifestations, according to severity, treatment, and environment. The aim of this study was to provide population-representative YLDs of noncommunicable diseases and injuries using a prevalence-based approach, with the disability weight measured in subjects with specific diseases or injuries. We included a total of 44969 adults, who completed the EQ-5D questionnaire as participation in the Korea National Health and Nutrition Examination Survey 2007–2014. We estimated the prevalence of each of 40 conditions identified from the noncommunicable diseases and injuries in the WHO list. Modified condition-specific disability-weight was determined from the adjusted mean difference of the EQ-5D index between the condition and reference groups. Condition-specific YLDs were calculated as the condition’s prevalence multiplied by the condition’s disability-weight. All-cause YLDs, estimated as “number of population × (1 − mean score of EQ-5D)” were 2165 thousands in 39044 thousand adults aged ≥20. The combined YLDs for all 40 conditions accounted for 67.6% of all-cause YLDs, and were 1604, 2126, 8749, and 12847 per 100000 young (age 20−59) males, young females, old (age ≥60) males, and old females, respectively. Back pain/osteoarthritis YLDs were exceptionally large (442/40, 864/146, 2037/836, and 4644/3039 per 100000 young males, young females, old males, and old females, respectively). Back pain, osteoarthritis, depression, diabetes, periodontitis, and stroke accounted for 22.3%, 9.1%, 4.6%, 3.3%, 3.2%, and 2.9% of all-cause YLDs, respectively. In conclusion, this estimation of YLDs using prevalence rates and disability-weights measured in a population-representative survey may form the basis for population-level strategies to prevent age-related worsening of disability. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed.
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Ma, Yan, Dong, Ming, Zhou, Kehua, Mita, Carol, Liu, Jianping, and Wayne, Peter M.
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AFFECTIVE disorders , *MENTAL health services , *ACUPUNCTURE research , *DISEASE prevalence , *PAIN management , *DIAGNOSIS - Abstract
Objective: Acupuncture has become popular and widely practiced in many countries around the world. Despite the large amount of acupuncture-related literature that has been published, broader trends in the prevalence and scope of acupuncture research remain underexplored. The current study quantitatively analyzes trends in acupuncture research publications in the past 20 years. Methods: A bibliometric approach was used to search PubMed for all acupuncture-related research articles including clinical and animal studies. Inclusion criteria were articles published between 1995 and 2014 with sufficient information for bibliometric analyses. Rates and patterns of acupuncture publication within the 20 year observational period were estimated, and compared with broader publication rates in biomedicine. Identified eligible publications were further analyzed with respect to study type/design, clinical condition addressed, country of origin, and journal impact factor. Results: A total of 13,320 acupuncture-related publications were identified using our search strategy and eligibility criteria. Regression analyses indicated an exponential growth in publications over the past two decades, with a mean annual growth rate of 10.7%. This compares to a mean annual growth rate of 4.5% in biomedicine. A striking trend was an observed increase in the proportion of randomized clinical trials (RCTs), from 7.4% in 1995 to 20.3% in 2014, exceeding the 4.5% proportional growth of RCTs in biomedicine. Over the 20 year period, pain was consistently the most common focus of acupuncture research (37.9% of publications). Other top rankings with respect to medical focus were arthritis, neoplasms/cancer, pregnancy or labor, mood disorders, stroke, nausea/vomiting, sleep, and paralysis/palsy. Acupuncture research was conducted in 60 countries, with the top 3 contributors being China (47.4%), United States (17.5%), and United Kingdom (8.2%). Retrieved articles were published mostly in complementary and alternative medicine (CAM) journals with impact factors ranging between 0.7 and 2.8 in the top 20 journals, followed by journals specializing in neuroscience, pain, anesthesia/analgesia, internal medicine and comprehensive fields. Conclusion: Acupuncture research has grown markedly in the past two decades, with a 2-fold higher growth rate than for biomedical research overall. Both the increases in the proportion of RCTs and the impact factor of journals support that the quality of published research has improved. While pain was a consistently dominant research focus, other topics gained more attention during this time period. These findings provide a context for analyzing strengths and gaps in the current state of acupuncture research, and for informing a comprehensive strategy for further advancing the field. [ABSTRACT FROM AUTHOR]
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- 2016
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20. Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study.
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Nezvalová-Henriksen, Kateřina, Wood, Mollie, Spigset, Olav, and Nordeng, Hedvig
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BIRTH weight , *GESTATIONAL age , *IBUPROFEN , *NONSTEROIDAL anti-inflammatory agents , *POPULATION-based case control , *THERAPEUTICS - Abstract
Objectives: Three studies so far have investigated the effect of prenatal non-steroidal anti-inflammatory drug (NSAID) exposure on birth weight and gestational age. The aim in this study was to evaluate the association of prenatal ibuprofen with birth weight and gestational age at birth, using a sibling design in an attempt to adjust for the possibility of familial confounding. Design: Using data from the Norwegian Mother and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we identified 28 597 siblings, of whom 1080 were prenatally exposed to ibuprofen and 26 824 were not exposed to any NSAID. Random and fixed effects models with propensity score adjustment were used to evaluate the effects of ibuprofen exposure on birth weight and gestational age. Results: Ibuprofen exposure during the first trimester was associated with a decrease in birth weight of 79 grams (95% confidence interval -133 to -25 grams). In contrast, second and/or third trimester exposure, and duration of exposure had no impact on the effect estimates. We found no association between ibuprofen exposure and gestational age at birth. Conclusions: Our results suggest that prenatal exposure to ibuprofen during the first trimester is associated with a slight decrease in birth weight. The association does not seem to be attributable to shared genetics and family environment, and could be explained by either exposure to ibuprofen, or to non-shared confounding between pregnancies. [ABSTRACT FROM AUTHOR]
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- 2016
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21. Survey of herbal cannabis (marijuana) use in rheumatology clinic attenders with a rheumatologist confirmed diagnosis.
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Ste-Marie, Peter A., Shir, Yoram, Rampakakis, Emmanouil, Sampalis, John S., Karellis, Angela, Cohen, Martin, Starr, Michael, Ware, Mark A., and Fitzcharles, Mary-Ann
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MEDICAL marijuana , *RHEUMATOLOGY , *PAIN management , *RHEUMATOLOGISTS , *CANNABINOIDS , *OSTEOARTHRITIS , *DRUG therapy for rheumatism , *RHEUMATISM , *SELF-evaluation , *SMOKING , *VISUAL analog scale - Abstract
Cannabinoids may hold potential for the management of rheumatic pain. Arthritis, often self-reported, is commonly cited as the reason for the use of medicinal herbal cannabis (marijuana). We have examined the prevalence of marijuana use among 1000 consecutive rheumatology patients with a rheumatologist-confirmed diagnosis and compared in an exploratory manner the clinical characteristics of medicinal users and nonusers. Current marijuana use, medicinal or recreational, was reported by 38 patients (3.8%; 95% CI: 2.8-5.2). Ever use of marijuana for medical purposes was reported by 4.3% (95% CI: 3.2-5.7), with 28 (2.8%; 95% CI: 1.9-4.0) reporting current medicinal use. Current medicinal users had a spectrum of rheumatic conditions, with over half diagnosed with osteoarthritis. Medicinal users were younger, more likely unemployed or disabled, and reported poorer global health. Pain report and opioid use was greater for users, but they had similar physician global assessment of disease status compared with nonusers. Medicinal users were more likely previous recreational users, with approximately 40% reporting concurrent recreational use. Therefore, less than 3% of rheumatology patients reported current use of medicinal marijuana. This low rate of use in patients with a rheumatologist-confirmed diagnosis is in stark contrast to the high rates of severe arthritis frequently reported by medicinal marijuana users, especially in Canada. Familiarity with marijuana as a recreational product may explain use for some as disease status was similar for both groups. [ABSTRACT FROM AUTHOR]
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- 2016
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22. Demystifying Cannabis
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Emily Lammers and Roberta Dume
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Drug ,medicine.medical_specialty ,Synthetic derivatives ,Substance-Related Disorders ,media_common.quotation_subject ,Pain ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Rheumatic pain ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Psychiatry ,Adverse effect ,Cannabis ,media_common ,Advanced and Specialized Nursing ,030222 orthopedics ,biology ,Cannabinoids ,business.industry ,biology.organism_classification ,Neuropathic pain ,Neuralgia ,Anxiety ,medicine.symptom ,business ,Cannabidiol ,medicine.drug - Abstract
The uses for cannabis and its synthetic derivatives continue to grow, as the regulatory status surrounding the drug becomes more legalized. Cannabis is composed of many chemical compounds, called cannabinoids, of which cannabidiol and 9-tetrahydrocannabinol have been studied for medicinal uses. As a modality for treatment of pain, cannabis may have benefit for use in treatment of neuropathic pain, with limited data for use in rheumatic pain. However, there are both short-term and long-term adverse effects with cannabis use that should be monitored in those who use cannabis for medicinal purposes, which include worsened anxiety and potential development of cannabis use disorder.
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- 2020
23. Effect on The Decrease Intensity Gymnastics Rheumatic Pain in Patients Gout Arthritis
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Fira Dewi Cahyani, Fajar Surachmi, and Sri Eny Setyowati
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musculoskeletal diseases ,medicine.medical_specialty ,business.industry ,Arthritis ,Pain scale ,medicine.disease ,Intensity (physics) ,Internal medicine ,Joint pain ,medicine ,Rheumatic pain ,Gout arthritis ,In patient ,medicine.symptom ,business ,Rheumatism - Abstract
Background: One of complaints caused by gout arthritis one of which is joint pain. Deposition of urate crystals in joints and tendons to continue and cause damage that will restrict the movement of the joint. Gouty arthritis is characterized by the accumulation of monosodium urate crystals in or around the joints. Monosodium urate crystals activates osteoblasts to secrete cytokines and lower the anabolic functions that will contribute to the destruction juxta-articular bone. Therefore, it is necessary interventions are triggered reduction in pain intensity exercise rheumatism. Purpose: Knowing the influence of gymnastics rheumatism to changes in the intensity of pain in patients with arthritis in the Gunungpati Health Center Working Area. Methods: This study uses a Pre-Experimental one group pre and post-test without control group design. The research sample of 15 people with gout arthritis in Puskesmas Gunungpati Semarang on 1 to 7 April 2019. The sampling technique with purposive sampling and analysis of data processing with the Wilcoxon test. Results: The results showed a pain scale before treatment equal to 4.67 ± 0724 and the scale of pain after treatment decreased to 0.60 ± 0.507. The results of the analysis using the Wilcoxon test shows the p value 0.000 which proves that there is a significant difference between before and after treatment of arthritis exercises to decrease pain scale in patients with gout arthritis. Conclusion: In this study indicate that there is influence of the reduction scale gymnastics rheumatic pain in gouty arthritis patients in Puskesmas Gunungpati Semarang.
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- 2019
24. Print Style
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Holkham, Tony and Holkham, Tony
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- 1995
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25. The Effect Of Back Massage Therapy On Rheumatic Pain In The Elderly In The Geriatric Clinic Kesdam Cijantung Hospital, East Jakarta Year 2019
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Samsuni Samsuni, Susilowati Susilowati, and Fajar Susanti
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Research design ,medicine.medical_specialty ,Massage ,business.industry ,Geriatric clinic ,social sciences ,Disease ,medicine.disease ,Test (assessment) ,Rating scale ,Physical therapy ,Medicine ,Rheumatic pain ,business ,human activities ,Rheumatism - Abstract
Rheumatic disease is a chronic joint inflammatory disease caused by an autoimmune disorder. Pain is a clinical complaint most frequently encountered by nurses. This study aims to determine the comparison of the results of back message therapy and not back message therapy with pain in elderly rheumatism. This study is a quantitative study with a quasi-experimental research design made using a non-equivalent group design with pre and post tests. The research sample was 18 respondents. The sampling technique used purposive sampling. Data collection using experimental method. The instrument for measuring the level of pain uses a numerical rating scale (NRS) . From the results of statistical analysis using the Independent Sample Test, it is known that the average difference in the measurement results of back message therapy in the pre category of 5.22 and post is 2.00 with p value = 0.000 (
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- 2021
26. Ligusticum chuanxiong Hort.
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Tang, Weici, Eisenbrand, Gerhard, Tang, Weici, and Eisenbrand, Gerhard
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- 1992
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27. Pengaruh Pijat (Massage) terhadap Perubahan Intensitas Nyeri Rematik pada Lansia di Desa Kertapati Puskesmas Dusun Curup Bengkulu Utara
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Feny Marlena and Rita Juniarti
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Nursing care ,medicine.medical_specialty ,Massage ,business.industry ,Psychological intervention ,Physical therapy ,Medicine ,Rheumatic pain ,business ,Pre and post - Abstract
The purpose of this study was to determine the effect of massage on the intensity of rheumatic pain in the elderly in the village of Kertapati, Puskesmas, Dusun Curup, North Bengkulu. This research is a quantitative study using a quasi experimental research design with pre and post test design research designs. The sample in this study amounted to 10 people taken by purposive sampling technique. The analysis used is univariate analysis and bivariate analysis, the statistical test used is the t-dependent test. The results of the study, the average value of rheumatic pain before a massage intervention (massage) in the elderly in the village of Kertapati, Curup Hamlet North Bengkulu is 5.2 and after the intervention is 3.4. T-dependent test results found that there were significant differences in the value of pain before and after massage intervention (massage) with a value of 0,000. In conclusion, there is an effect of massage on the intensity of rheumatic pain in the elderly in the village of Kertapati, Puskesmas, Dusun Curup, North Bengkulu. It is expected to provide optimal nursing care, especially massage interventions to the elderly and can socialize massage skills to the elderly, so that they can independently massage when there is a pain attack.Keywords: Elderly, Rheumatic Pain, Massage
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- 2019
28. Ethnobotanical notes about medicinal and useful plants of the Reventino Massif tradition (Calabria region, Southern Italy)
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Domenico Turiano, Gaetano Laghetti, Giovanni Spampinato, Carmelo Maria Musarella, and Gina Maruca
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0106 biological sciences ,0301 basic medicine ,geography ,geography.geographical_feature_category ,biology ,business.industry ,Plant Science ,Massif ,biology.organism_classification ,01 natural sciences ,Useful plants ,03 medical and health sciences ,030104 developmental biology ,Agriculture ,Ethnobotany ,Genetics ,Plant species ,Rheumatic pain ,Lamiaceae ,Socioeconomics ,Medicinal plants ,business ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics ,010606 plant biology & botany - Abstract
This paper presents an ethnobotanical survey of the traditional uses of plants in the Reventino Massif (Calabria Region, Southern Italy). The aim of study was to record local knowledge on plants used for food, medical and other purposes based on new information provided by inhabitants in the study area. Fifty people, aged between 52 and 91 years, were interviewed between January and June 2016, using open and semi-structured ethnobotanical interviews. For each described plant species, the Italian common and local folk names, the part of the plants used, the uses and the relative use value (UV), were recorded. 76 plant species belonging to 43 families have been identified, with Asteraceae (10 species) and Lamiaceae (9 species) being most frequently used. The decoction and infusion in water, is the main preparation method for oral administration, while direct application of plants is the most important method for topical use. Several uses were never reported before. Phytotherapy in the Reventino Massif Area is nowadays practiced by a few elderly people that resort to medicinal plants only for various mild complaints such as tooth-ache, rheumatic pain, headaches; they also serve as first aid, as cicatrizing, lenitive, haemostatic agents. On the contrary, food uses are still commonly practiced.
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- 2019
29. Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism
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Shival Srivastava, Rakesh Jangir, Gaurav Kandel, Ravindra Shukla, Shrimanjunath Sankanagoudar, Monica Agarwal, and Mayank Ganeshani
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Male ,Physiology ,Organic chemistry ,Gastroenterology ,Arthritis, Rheumatoid ,Endocrinology ,Immune Physiology ,Medicine and Health Sciences ,Vitamin D ,skin and connective tissue diseases ,media_common ,Subclinical infection ,Innate Immune System ,Multidisciplinary ,Primary hypothyroidism ,Vitamins ,Arthralgia ,Physical sciences ,Chemistry ,Rheumatoid arthritis ,Medicine ,Cytokines ,Female ,hormones, hormone substitutes, and hormone antagonists ,Research Article ,Risk ,medicine.medical_specialty ,endocrine system ,Endocrine Disorders ,Science ,Immunology ,Pain ,Reference range ,Rheumatoid Arthritis ,Systemic Lupus Erythematosus ,Autoimmune Diseases ,Chemical compounds ,Signs and Symptoms ,Hypothyroidism ,Rheumatology ,Internal medicine ,Organic compounds ,medicine ,Vitamin D and neurology ,media_common.cataloged_instance ,Humans ,European union ,Rheumatic Pain ,Aged ,Retrospective Studies ,Lupus Erythematosus ,business.industry ,Arthritis ,Biology and Life Sciences ,Retrospective cohort study ,Dehydroepiandrosterone ,Molecular Development ,medicine.disease ,Immune System ,Clinical Immunology ,Clinical Medicine ,business ,Rheumatism ,Developmental Biology - Abstract
Introduction The presence of rheumatism is well recognized in primary hypothyroidism. Dehydroepiandrstenedione sulphate (DHEAS) is associated with rheumatological diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study aims to explore relationship between joint pains and DHEAS levels in primary hypothyroidism. Methods Retrospective study of 78 subjects with subclinical hypothyroidism, with TSH within reference range. The joint pains were evaluated by European Union League against rheumatism (EULAR-CSA) score and compared with serum DHEAS, RA factor, Anti-TPO antibody, highly sensitive C-recative protein (hsCRP), vitamin D levels. Result DHEAS levels Conclusion Lower DHEAS predicts clinical features of imminent RA in subjects with primary hypothyroidism. This is akin to low DHEAS seen in many rheumatological disease with possibly similar mechanism. Another possibility is low DHEAS alters hepato-hypothalamo pituitary adrenal axis in presense of cytokines and induces a hitherto unrecognized state of pre rheumatoid arthritis like syndrome. Future studies on primary hypothyroidism should focus on role of lower DHEAS levels in inducing symptoms of fatigue and joint pains.
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- 2021
30. Behavioral Trait of Morningness-Eveningness in Association with Articular and Spinal Diseases in a Population.
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Merikanto, Ilona, Lahti, Tuuli, Seitsalo, Seppo, Kronholm, Erkki, Laatikainen, Tiina, Peltonen, Markku, Vartiainen, Erkki, and Partonen, Timo
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MORNINGNESS-Eveningness Questionnaire , *MUSCULOSKELETAL system diseases , *SPINE diseases , *JOINT diseases , *HEALTH risk assessment , *MENTAL depression - Abstract
Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089), as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Finland. Chronotype was assessed based on six items from the original Horne-Östberg Morningness-Eveningness Questionnaire. Information about risk factors and the diagnoses of articular and spinal diseases were based on the self-reported information. Our results suggest that Evening-types have higher odds for articular and spinal diseases as compared with Morning-types, and this risk is heightened especially regarding spinal disease and backache (odds ratios of 1.8 to 2.1, and 1.6 to 1.8, respectively) and remains significant after controlling for the sex, age, education, civil status, physical activity, alcohol use, and smoking, and additionally for the body-mass index, insufficient sleep, or depressive symptoms. [ABSTRACT FROM AUTHOR]
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- 2014
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31. Primary care physician perspectives on screening for axial spondyloarthritis: A qualitative study
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Esther Yi, Daniel Lindstrom, Shao-Hsien Liu, Kate L. Lapane, S. Khan, Catherine Dubé, Jonathan Kay, Ariel L. Beccia, and Divya Shridharmurthy
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Male ,Health Care Providers ,Sports Medicine ,Medicine and Health Sciences ,Back pain ,Electronic Health Records ,Mass Screening ,Medical Personnel ,Axial spondyloarthritis ,Immune Response ,Qualitative Research ,Multidisciplinary ,Middle Aged ,Qualitative Studies ,Professions ,Research Design ,Medicine ,Female ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Patients ,Science ,Immunology ,MEDLINE ,Pain ,Primary care ,Research and Analysis Methods ,Physicians, Primary Care ,Signs and Symptoms ,Rheumatology ,General Practitioners ,Diagnostic Medicine ,Physicians ,Spondylarthritis ,medicine ,Humans ,Primary Care ,Rheumatic Pain ,Inflammation ,Primary Health Care ,business.industry ,Primary care physician ,Biology and Life Sciences ,Health Care ,Mechanical back pain ,Back Pain ,Purposeful sampling ,Family medicine ,People and Places ,Population Groupings ,Clinical Medicine ,business ,Qualitative research - Abstract
Background Many patients with axial spondylarthritis (axSpA) experience lengthy diagnostic delays upwards of 14 years. (5–14 years). Screening tools for axSpA have been proposed for use in primary care settings, but whether this approach could be implemented into busy primary care settings remains unknown. Objective To solicit feedback from primary care physicians regarding questions from the Inflammatory Back Pain Assessment: the Assessment of Spondyloarthritis International Society (ASAS) Expert Criteria and gain insight about barriers and facilitators for implementing axSpA screening in primary care. Methods Guided by Consolidated Criteria for reporting Qualitative Research (COREQ-criteria), we recorded, transcribed, and analyzed in-depth interviews with eight family medicine physicians and ten internists (purposeful sampling) using immersion/crystallization techniques. Results Few physicians reported awareness of existing classification criteria for axSpA, and many reported a lack of confidence in their ability to distinguish between inflammatory and mechanical back pain. From three domains, 10 subthemes emerged: 1) typical work-up of axSpA patients in primary care, with subthemes including the clues involved in work-up and role of clinical examinations for axSpA; 2) feedback on questions from the Inflammatory Back Pain Assessment: ASAS Expert Criteria, with subthemes to evaluate contents/questions of a potential screening tool for axSpA; and 3) implementation of the screening tool in primary care settings, with subthemes of perceived barriers including awareness, time, other conditions to screen, rare disease, and lack of structured questionnaire for back pain and perceived facilitators including workflow issues and awareness. Conclusions Primary care physicians believed that an improved screening instrument and a strong evidence-base to support the need for screening for axSpA are required. The implementation of axSpA screening into a busy primary care practice requires integration into the practice workflow, with use of technology suggested as a possible way to improve efficiency.
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- 2021
32. Predicting pain among female survivors of recent interpersonal violence: A proof-of-concept machine-learning approach
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Francisco Sanchez-Saez, Subodh Nag, Natalie Hellman, Brooklynn Bailey, Kerry L. Kinney, Amber Williams, Uma Rao, Matthew E. Kutcher, Edward W. Lannon, Burel R. Goodin, Matthew C. Morris, and Michiels, Sarah
- Subjects
Coping (psychology) ,Epidemiology ,Sensory Physiology ,Social Sciences ,Intimate Partner Violence ,Violence Against Women ,Criminology ,Pediatrics ,Biochemistry ,Cortisol ,Stress Disorders, Post-Traumatic ,0302 clinical medicine ,Sociology ,Adaptation, Psychological ,Public and Occupational Health ,Child Abuse ,Lipid Hormones ,Young adult ,Aetiology ,Pain Research ,Cognition ,Sensory Systems ,Justice and Strong Institutions ,Somatosensory System ,030220 oncology & carcinogenesis ,Medicine ,Crime ,Chronic Pain ,social and economic factors ,medicine.medical_specialty ,Science ,Neuropsychiatric Disorders ,Violence ,03 medical and health sciences ,Signs and Symptoms ,Rheumatology ,Clinical Research ,Intervention (counseling) ,Humans ,Adaptation ,Steroid Hormones ,Peace ,domestic violence ,Public health ,Battered Women ,Prevention ,Biology and Life Sciences ,Pain Sensation ,medicine.disease ,Hormones ,Post-Traumatic ,Psychological ,Clinical Medicine ,030217 neurology & neurosurgery ,Neuroscience ,Child abuse ,Physiology ,intimate partner violence ,Machine Learning ,Medicine and Health Sciences ,Scopus ,Survivors ,Stress Disorders ,Violence Research ,Multidisciplinary ,Traumatic Injury Risk Factors ,Post-Traumatic Stress Disorder ,Rehabilitation ,Chronic pain ,Post-Traumatic Stress Disorder (PTSD) ,Anxiety Disorders ,Family life ,Mental Health ,JCR ,Female ,pregnancy ,Clinical psychology ,Research Article ,Adult ,Adolescent ,General Science & Technology ,Pain ,Neuroses ,Young Adult ,2.3 Psychological ,Mental Health and Psychiatry ,Behavioral and Social Science ,medicine ,Violent Crime ,Rheumatic Pain ,business.industry ,Neurosciences ,Brain Disorders ,Medical Risk Factors ,Spouse Abuse ,Injury (total) Accidents/Adverse Effects ,business ,Mind and Body - Abstract
Interpersonal violence (IPV) is highly prevalent in the United States and is a major public health problem. The emergence and/or worsening of chronic pain are known sequelae of IPV; however, not all those who experience IPV develop chronic pain. To mitigate its development, it is critical to identify the factors that are associated with increased risk of pain after IPV. This proof-of-concept study used machine-learning strategies to predict pain severity and interference in 47 young women, ages 18 to 30, who experienced an incident of IPV (i.e., physical and/or sexual assault) within three months of their baseline assessment. Young women are more likely than men to experience IPV and to subsequently develop posttraumatic stress disorder (PTSD) and chronic pain. Women completed a comprehensive assessment of theory-driven cognitive and neurobiological predictors of pain severity and pain-related interference (e.g., pain, coping, disability, psychiatric diagnosis/symptoms, PTSD/trauma, executive function, neuroendocrine, and physiological stress response). Gradient boosting machine models were used to predict symptoms of pain severity and pain-related interference across time (Baseline, 1-,3-,6- follow-up assessments). Models showed excellent predictive performance for pain severity and adequate predictive performance for pain-related interference. This proof-of-concept study suggests that machine-learning approaches are a useful tool for identifying predictors of pain development in survivors of recent IPV. Baseline measures of pain, family life impairment, neuropsychological function, and trauma history were of greatest importance in predicting pain and pain-related interference across a 6-month follow-up period. Present findings support the use of machine-learning techniques in larger studies of post-IPV pain development and highlight theory-driven predictors that could inform the development of targeted early intervention programs. However, these results should be replicated in a larger dataset with lower levels of missing data.
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- 2021
33. Amazonian Siparuna extracts as potential anti-influenza agents: Metabolic fingerprinting
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Suzana G. Leitão, Gabrielle do Vale, Rosineide Costa Simas, Carla Monteiro Leal, Gilda Guimarães Leitão, Brendo Araujo Gomes, Marilda M. Siqueira, Carlos Vitor Gomes de Almeida, Mariana Freire Campos, and Milene Miranda
- Subjects
Spectrometry, Mass, Electrospray Ionization ,Cell Survival ,Antiviral Agents ,Virus ,Catechin ,Anti-influenza Agents ,Madin Darby Canine Kidney Cells ,03 medical and health sciences ,0302 clinical medicine ,Alkaloids ,Dogs ,Influenza A Virus, H1N1 Subtype ,Tandem Mass Spectrometry ,Siparuna ,Drug Discovery ,Rheumatic pain ,Animals ,Biflavonoids ,Proanthocyanidins ,Inhibitory effect ,Chromatography, High Pressure Liquid ,030304 developmental biology ,Pharmacology ,chemistry.chemical_classification ,Flavonoids ,0303 health sciences ,Traditional medicine ,biology ,Plant Extracts ,Glycoside ,biology.organism_classification ,Plant Leaves ,chemistry ,Viral replication ,030220 oncology & carcinogenesis ,Toxicity ,Laurales ,Medicine, Traditional ,Brazil - Abstract
Ethnopharmacological relevance Siparuna species are used in Brazilian Folk Medicine for the treatment and prophylaxis of colds, fever, headache, gastrointestinal disorders and rheumatic pain. Aim of the study This study aimed to investigate a possible anti-influenza activity of 25 extracts from leaves of Amazonian S. cristata, S. decipiens, S. glycycarpa, S. reginae and S. sarmentosa based on their folk medicinal uses as well as to investigate their metabolic fingerprinting. The chemical composition of the active extracts was further dereplicated. Material and methods The chemical composition of the crude EtOH extracts from five Siparuna species were investigated by ESI (±) LC-QTOF-MS2. Organic extracts were obtained by liquid-liquid partition with solvents of increasing polarity, generating 25 extracts which were subjected to a quick DI-ESI (±) IT-MS fingerprint analysis. These extracts were tested against influenza virus replication and cellular toxicity using MDCK cells and influenza A/Michigan/45/2015 (H1N1)pdm09 virus. The compounds in the active BuOH extracts from S. glycycarpa and S. sarmentosa were annotated by ESI (±) LC-QTOF-MS2. Results Analysis of the EtOH extracts revealed the presence of alkaloids and flavonoids, in the positive and negative ionization modes. Out of the 25 organic extracts screened for their antiviral activity, the BuOH extracts from S. glycycarpa and S. sarmentosa were the most active, inhibiting 96.0 ± 1.3% and 89.5 ± 0.8% of influenza virus replication 24 h post-infection. These inhibitory effects were maintained until 72hpi. Alkaloids, O- and C-flavonoid glycosides, dihydrochalcones and a procyanidin dimer were annotated in these extracts. Conclusions The inhibitory effect against influenza A(H1N1)pdm09 virus replication shown by Amazonian Siparuna species corroborates the use of these plants in Brazilian Folk Medicine, showing their potential as anti-influenza agents. These promising results stimulate the continuation of this study with the aim of isolating the compound(s) responsible for this bioactivity, thus contributing to a better knowledge of those species and to the research of natural products with potential anti-influenza activity.
- Published
- 2020
34. Role of mtDNA Haplogroups in the Prevalence of Osteoarthritis in Different Geographic Populations: A Meta-Analysis.
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Shen, Jin-Ming, Feng, Lei, and Feng, Chun
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OSTEOARTHRITIS , *ARTHRITIS , *META-analysis , *MITOCHONDRIAL DNA , *CONFIDENCE intervals - Abstract
Background: Osteoarthritis (OA) is the most common form of arthritis and has become an increasingly important public-health problem. However, the pathogenesis of OA is still unclear. In recent years, its correlation with mtDNA haplogroups attracts much attention. We aimed to perform a meta-analysis to investigate the association between mtDNA haplogroups and OA. Methods: Published English or Chinese literature from PubMed, Web of Science, SDOS, and CNKI was retrieved up until April 15, 2014. Case-control or cohort studies that detected the frequency of mtDNA haplogroups in OA patients and controls were included. The quality of the included studies was evaluated by the Newcastle-Ottawa Scale (NOS) assessment. A meta-analysis was conducted to calculate pooled odds ratio (OR) with 95% confidence interval (CI) through the random or fixed effect model, which was selected based on the between-study heterogeneity assessed by Q test and I2 test. Subgroup analysis was performed to explore the origin of heterogeneity. Results: A total of 6 case-control studies (10590 cases and 7161 controls) with an average NOS score of 6.9 were involved. For the analysis between mtDNA haplogroup J and OA, random model was selected due to high heterogeneity. No significant association was found initially (OR = 0.73, 95%CI: 0.52–1.03), however, once any study from UK population was removed the association emerged. Further subgroup analysis demonstrated that there was a significant association in Spain population (OR = 0.57, 95%CI: 0.46–0.71), but not in UK population. Also, subgroup analysis revealed that there was a significant correlation between cluster TJ and OA in Spain population (OR = 0.70, 95%CI: 0.58–0.84), although not in UK population. No significant correlation was found between haplogroup T/cluster HV/cluster KU and OA. Conclusions: Our current meta-analysis suggests that mtDNA haplogroup J and cluster TJ correlate with the risk of OA in Spanish population, but the associations in other populations require further investigation. [ABSTRACT FROM AUTHOR]
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- 2014
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35. The Association of Depression and Anxiety with Pain: A Study from NESDA.
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de Heer, Eric W., Gerrits, Marloes M. J. G., Beekman, Aartjan T. F., Dekker, Jack, van Marwijk, Harm W. J., de Waal, Margot W. M., Spinhoven, Philip, Penninx, Brenda W. J. H., and van der Feltz-Cornelis, Christina M.
- Subjects
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ANXIETY , *CHRONIC pain , *PAIN tolerance , *DEPRESSED persons - Abstract
Chronic pain is commonly co-morbid with a depressive or anxiety disorder. Objective of this study is to examine the influence of depression, along with anxiety, on pain-related disability, pain intensity, and pain location in a large sample of adults with and without a depressive and/or anxiety disorder. The study population consisted of 2981 participants with a depressive, anxiety, co-morbid depressive and anxiety disorder, remitted disorder or no current disorder (controls). Severity of depressive and anxiety symptoms was also assessed. In separate multinomial regression analyses, the association of presence of depressive or anxiety disorders and symptom severity with the Chronic Pain Grade and location of pain was explored. Presence of a depressive (OR = 6.67; P<.001), anxiety (OR = 4.84; P<.001), or co-morbid depressive and anxiety disorder (OR = 30.26; P<.001) was associated with the Chronic Pain Grade. Moreover, symptom severity was associated with more disabling and severely limiting pain. Also, a remitted depressive or anxiety disorder showed more disabling and severely limiting pain (OR = 3.53; P<.001) as compared to controls. A current anxiety disorder (OR = 2.96; p<.001) and a co-morbid depressive and anxiety disorder (OR = 5.15; P<.001) were more strongly associated with cardio-respiratory pain, than gastro-intestinal or musculoskeletal pain. These findings remain after adjustment for chronic cardio respiratory illness. Patients with a current and remitted depressive and/or anxiety disorder and those with more severe symptoms have more disabling pain and pain of cardio-respiratory nature, than persons without a depressive or anxiety disorder. This warrants further research. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
36. “I Try and Smile, I Try and Be Cheery, I Try Not to Be Pushy. I Try to Say ‘I'm Here for Help’ but I Leave Feeling… Worried”: A Qualitative Study of Perceptions of Interactions with Health Professionals by Community-Based Older Adults with Chronic Pain
- Author
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Clarke, Amanda, Martin, Denis, Jones, Derek, Schofield, Patricia, Anthony, Geraldine, McNamee, Paul, Gray, Denise, and Smith, Blair H.
- Subjects
- *
OLDER people , *QUALITY of life , *CHRONIC pain , *MEDICAL personnel , *SOCIAL comparison - Abstract
Background: Over 50% of community-dwelling older adults experience chronic pain, which threatens their quality of life. Of importance to their pain management is older people's interaction with health professionals that, if unsatisfactory, may impair the outcome. Aims: To add to the limited research specific to older people living with chronic pain in the community, we explored how they perceive their experiences of interacting with health professionals, seeking factors that might optimise these interactions. Methods: Purposive sampling was used to recruit men and women >65 years with self-reported musculoskeletal chronic pain. Qualitative individual interviews and one group interview were undertaken with 23 participants. Data were transcribed verbatim and underwent Framework Analysis. Results: Three themes were identified. Seeking help illustrates issues around why older people in the community may or may not seek help for chronic pain, and highlights the potential involvement of social comparison. Importance of diagnosis illustrates the desire for professional validation of their condition and an aversion to vague explanations based on the person's age. Being listened to and being heard illustrates the importance of empathic communication and understanding expectations, with due respect for the person's age. Conclusions: In common with people of all ages, an effective partnership between an older person in pain and health professionals is essential if pain is to be reported, appropriately assessed and managed, because of the subjective nature of pain and its treatment responses. For older people with pain, perception about their age, by both parties in the partnership, is an additional factor that can unnecessarily interfere with the effectiveness of this partnership. Health professionals should engage with older adults to clarify their expectations about pain and its management, which may be influenced by perceptions about age; and to encourage expression of their concerns, which may also be affected by perceptions about age. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
37. The impact of functional medicine on patient-reported outcomes in inflammatory arthritis: A retrospective study
- Author
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Mark Hyman, Nicole Droz, Yuxuan Jin, Michelle Beidelschies, Patrick Hanaway, and M. Elaine Husni
- Subjects
Male ,Patient-Reported Outcomes Measurement Information System ,Inflammatory arthritis ,Health Status ,Global Health ,Arthritis, Rheumatoid ,0302 clinical medicine ,Medicine and Health Sciences ,Public and Occupational Health ,Inflammatory Arthritis ,030212 general & internal medicine ,Precision Medicine ,Functional medicine ,Multidisciplinary ,Middle Aged ,Mental Health ,Rheumatoid arthritis ,Medicine ,Female ,Research Article ,Adult ,medicine.medical_specialty ,Science ,Immunology ,MEDLINE ,Pain ,Rheumatoid Arthritis ,Autoimmune Diseases ,03 medical and health sciences ,Psoriatic arthritis ,Signs and Symptoms ,Rheumatology ,Internal medicine ,Mental Health and Psychiatry ,medicine ,Humans ,Patient Reported Outcome Measures ,Rheumatic Pain ,Nutrition ,Retrospective Studies ,030203 arthritis & rheumatology ,business.industry ,Arthritis ,Arthritis, Psoriatic ,Biology and Life Sciences ,Retrospective cohort study ,medicine.disease ,Diet ,Multivariate Analysis ,Clinical Immunology ,Clinical Medicine ,business ,Mental Health Therapies - Abstract
BackgroundDespite treatment advances for inflammatory arthritis, a significant amount of patients fail to achieve remission. Other modifiable factors such as diet, physical activity and environmental exposures may be an important area of focus to help patients achieve disease remission and greater overall health. Functional medicine focuses on these lifestyle factors and may be an important adjunctive therapy. In this study, we examined the impact of functional medicine on patient-reported outcomes in patients with inflammatory arthritis.Materials and methodsIn this 12-week, retrospective study, patients with confirmed diagnoses of rheumatoid arthritis (RA) or psoriatic arthritis (PsA) were treated according to guidelines from the American College of Rheumatology for RA or PSA respectively. Those in the functional medicine group underwent a functional medicine program adjunctive to the standard of care. Patient reported outcomes, such as PROMIS (Patient Reported Outcomes Measurement Information System) global physical health, mental health and pain scores were collected at baseline and 12 weeks. Multivariable statistical modeling was used to identify the impact of functional medicine on patient-reported outcomes.Results318 patients were screened and 54 patients (mean age 52.9±11.3 years, females 74(67.9%)), were included. Baseline characteristics were similar in both patient groups with the exception of PROMIS global physical health and pain (PROMIS global physical health score 43·2 ± 6·6 and 39·7 ± 8·7 and pain scores of 3·5 ± 1·9 and 5·2 ± 2·7 in the functional medicine group vs. standard of care group respectively). Using multivariable model to account for these differences, patients in the functional medicine group had a statistically significant reduction in pain (0.92, p-value = 0.007) and change in PROMIS physical health score (2·84, p-value = 0.001) as compared to the standard of care. Changes in PROMIS global mental health scores were also significant and were dependent on age and were greatest in those older than 55.LimitationsRetrospective design, baseline difference in patient reported outcomes.ConclusionsFunctional medicine may have an important role as adjunctive therapy to improve patients' pain, physical and mental health in those who do not see improvement with conventional therapy alone.
- Published
- 2020
38. DETERMINANTS OF MUSCULOSKELETAL DISORDERS IN COFFEE PICKER IN KABUPATEN LUMAJANG
- Author
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Kurnia Ardiansyah Akbar
- Subjects
Research design ,Right shoulder ,Health problems ,business.industry ,Environmental health ,Complaint ,Rheumatic pain ,Medicine ,business - Abstract
Musculoskeletal disorders become a attention in the Ocuupational health sector. One of the sectors that is affected is the agricultural sector. The results of previous studies indicate that musculoskeletal disorders in farmers will reduce up to 60% of farmer productivity. Musculoskeletal disorders are health problems that often occur in coffee pickers but are rarely noticed. Based on preliminary research from 30 respondents who were interviewed 100% of respondents claimed to experience rheumatic pain, cramps, sprains and numbness. Parts of the body that experienced complaints expressed by respondents had a variety of neck, right shoulder, left calf and waist. This complaint is an indication that coffee pickers have experienced musculoskeletal disorders. This study aims to analyze the musculoskletal disorders. The study was conducted on coffee pickers in 2 villages namely Tawon Songo and Jabon Villages Pasrujambe Kabupaten Lumajang with a total sample of 35 respondents taken by simple random sampling. The research design used was cross-sectional study. Based on the research results it was found that musculoskletal disorders were experienced by 32 respondents. Of the variables studied, two significant variables were risk factors for musculoskletal disorders, namely age (sig = 0.009) and burden (sig = 0.000).
- Published
- 2020
39. Discordance between the patient’s and physician’s global assessment in rheumatoid arthritis: data from the REAL study-Brazil
- Author
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Marcel Lobato Sauma, Karina Bonfiglioli, Júlia Brito de Medeiros, Sebastião Cezar Radominski, Licia Maria Henrique Mota, Gustavo Gomes Resende, Carla Jorge Machado, Gláucio Ricardo Werner de Castro, Isabela Araújo Santos, Paulo Louzada Júnior, Henrique Carriço da Silva, Ana Paula Monteiro Gomides, Manoel Barros Bertolo, Geraldo da Rocha Castelar-Pinheiro, Claiton Viegas Brenol, Ana Beatriz Vargas-Santos, Maria Raquel da Costa Pinto, Cleandro Pires de Albuquerque, Rina Dalva Neubarth Giorgi, Maria de Fátima Lobato da Cunha Sauma, Ricardo Machado Xavier, Nathalia de Carvalho Saciloto, Rodrigo Balbino Chaves Amorim, Fernanda Maria Borghi, Ivânio Alves Pereira, and Maria Fernanda Brandão Resende Guimarães
- Subjects
0301 basic medicine ,Male ,Visual Analog Scale ,Medical Doctors ,Health Care Providers ,Arthritis ,Pathology and Laboratory Medicine ,Global Health ,Severity of Illness Index ,Geographical locations ,Arthritis, Rheumatoid ,Disability Evaluation ,RELAÇÕES MÉDICO-PACIENTE ,0302 clinical medicine ,Quality of life ,Animal Cells ,Red Blood Cells ,Medicine and Health Sciences ,Medicine ,Public and Occupational Health ,Medical Personnel ,Pain Measurement ,Multidisciplinary ,Pain scale ,Middle Aged ,Dissent and Disputes ,Professions ,Rheumatoid arthritis ,Treatment strategy ,Regression Analysis ,Female ,Public Health ,Cellular Types ,Brazil ,Research Article ,medicine.medical_specialty ,Patients ,Visual analogue scale ,Science ,Immunology ,Pain ,Context (language use) ,Rheumatoid Arthritis ,Autoimmune Diseases ,03 medical and health sciences ,Signs and Symptoms ,Rheumatology ,Diagnostic Medicine ,Internal medicine ,Physicians ,Severity of illness ,Humans ,Rheumatic Pain ,030203 arthritis & rheumatology ,Blood Cells ,business.industry ,Biology and Life Sciences ,Cell Biology ,South America ,medicine.disease ,Health Care ,030104 developmental biology ,People and Places ,Quality of Life ,Population Groupings ,Clinical Immunology ,Clinical Medicine ,business - Abstract
Background Discordance between patient’s global assessment (PtGA) and physician’s global assessment (PhGA) has been described in rheumatoid arthritis (RA). Understanding the reasons for this discrepancy is important in the context of treat-to-target treatment strategy. Objective To assess the determinants of PtGA and PhGA and factors associated with discordance between them. Methods The REAL study included RA patients from Brazilian public health centers. Clinical, laboratory and outcomes measures were collected. PtGA and the PhGA were rated on a visual analog scale and analyzed. Three groups were defined: no discordance (difference between PtGA and PhGA within 3 cm), positive discordance (PtGA exceeding PhGA by >3 cm), and negative discordance (PtGA less than PhGA by >3 cm). Multivariate regression analysis was used to identify determinants of PtGA and PhGA and their discordance. Results 1115 patients (89,4% female, mean age 56.7y and median disease duration of 12.7y) were enrolled. Two factors were associated with PtGA in the final multivariate model: one point increase in the pain scale leads to an increase of 0.62 in PtGA; one point increase in HAQ increases by 9,25 points the PtGA. The factors associated with PhGA were pain scale, number of tender and swollen joints (NTJ and NSJ), positive RF, ESR, HAQ-DI and use of corticosteroids. Discordance between patient and physician was found in 30.52%: positive discordance in 24.6% and negative discordance in 5.92%. An increase of one point in the NSJ was associated with a 12% increase in the chance of negative discordance. The chance of positive discordance increased by 90% and 2% for each unit increased in HAQ-DI and pain scale respectively. Finally, the chance of positive discordance decreased by 3% for each point increased in NTJ and by 15% for each point increased in NSJ. Conclusion In one-third of the assessments, there was disagreement between PtGA and PhGA (a positive discordance was found in 80% of them). Pain and function were determinants for patients to estimate disease activity, while swollen joints was the main factor related to a worse physician’s evaluation. These data show how different can be the perspectives of patients and assistants.
- Published
- 2020
40. 'A body in transformation'—An empirical phenomenological study about fear‐avoidance beliefs towards physical activity among persons experiencing moderate‐to‐severe rheumatic pain
- Author
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Unn-Britt Johansson and Helena Lööf
- Subjects
Adult ,Male ,Body awareness ,Arthritis, Rheumatoid ,03 medical and health sciences ,Psoriatic arthritis ,Nursing care ,fear‐avoidance beliefs ,0302 clinical medicine ,body awareness ,Avoidance Learning ,medicine ,Humans ,Rheumatic pain ,pain ,030212 general & internal medicine ,Exercise ,General Nursing ,Aged ,Pain Measurement ,health‐enhancing physical activity ,Balance (ability) ,030504 nursing ,Self ,Arthritis, Psoriatic ,Fear ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,Anticipation ,Rheumatoid arthritis ,rheumatic diseases ,Female ,Original Article ,0305 other medical science ,Psychology ,Clinical psychology - Abstract
Aims and objectives To gain a better understanding of fear-avoidance beliefs towards physical activity and body awareness in people experiencing moderate-to-severe rheumatic pain. Background Rheumatoid arthritis and psoriatic arthritis are long-term conditions with pain as the prominent symptom. Health-promoting physical activity is recommended and can have an analgesic effect. High self-rated pain has previously been reported to be associated with increased fear-avoidance behaviour in relation to physical activity. Body awareness, which includes attentional focus and awareness of internal body sensations, could be valuable in the nursing care of long-term diseases. Design Empirical phenomenological. Methods An empirical phenomenological psychological method was applied. The interviews took place between autumn 2016-spring 2017 with 11 informants (eight women and three men, age range 44-71 years) who were diagnosed with rheumatoid arthritis (n = 7) or psoriatic arthritis (n = 4), with a disease duration ranging from 3-35 years. The mean visual analogue scale score in the study sample was 60 mm. Results Three typologies were identified: "My relatively fragile physical status", "I am an active creator" and "Part of something bigger than myself." Conclusions The current findings indicated that pain anticipation and fear-avoidance beliefs towards physical activity sometimes affected the behaviour of individuals with long-term rheumatic pain syndromes. People experiencing moderate-to-severe rheumatic pain tended to focus on their fragile physical and emotional state. By adopting a more favourable attitude towards the self, the body could be restored to a state of calm and balance. Relevance to clinical practice The current findings are relevant for healthcare professionals engaged in health-promotion clinical practice.
- Published
- 2018
41. Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain.
- Author
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Uehleke, B., Müller, J., Stange, R., Kelber, O., and Melzer, J.
- Abstract
Study objective: Efficacy and safety of willow bark extract for pain reduction in patients suffering from musculoskeletal disorders (MSD) has been shown in clinical short term trials. Therefore this observational study over 6 months should evaluate patterns of treatments like mono- or combinations therapy, dosage and safety during long-term treatment under pragmatic conditions with the aqueous willow bark extract STW 33-I, (Proaktiv
® ; drug-extract-ratio 16–23:1). Patients and methods: The patients were treated with STW 33-I; comedication with other NSAIDs and opioids was allowed. An extensive case report form including pain questionnaires and patient diary was used for outcome evaluation. Results: Four hundred and thirty-six patients with rheumatic pain mainly due to osteoarthritis (56.2%) and back pain (59.9%) were included. During the study the mean reductions from baseline value 58.4±22.6–31.8±22.5 after 24 weeks in the pain intensity scale (VAS 0–100mm) were significant even after 3 weeks with a reduction by 26mm (45.6% of the baseline value) at the end of the study. The relative reductions of the weekly means of the daily patient self-rated scores of the pain (6-point Likert-scales) were between 33% and 44% of the baseline values during the course of the study. We present results of subgroups according their analgetic/antiphlogistic comedication. The distribution and specification of the main adverse events and the ratings of the treatment showed a good tolerability. No relevant drug interactions were reported. Conclusion: These data suggest that STW 33-I can be used as a basic treatment in the long-term therapy of painful musculoskeletal disorders and that it can be combined with NSAIDs and opioids if necessary. [ABSTRACT FROM AUTHOR]- Published
- 2013
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42. Clinical examination algorithm in rheumatology
- Author
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Rovenský, Jozef, editor and Payer, Juraj, editor
- Published
- 2009
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43. Management of chronic pain in the rheumatic diseases with insights for the clinician.
- Author
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Fitzcharles, Mary-Ann and Shir, Yoram
- Abstract
Pain that accompanies musculoskeletal conditions should be regarded as an illness entity in its own right and deserves treatment in parallel with the management of the underlying condition. Recent understanding of the pathophysiology of rheumatic pain invokes interplay of the nociceptive mechanisms driven by local tissue factors and the neurogenic responses that sustain chronic pain. In line with other pain conditions, ideal treatment of rheumatic pain should be through a multimodal approach, integrating nonpharmacologic as well as pharmacologic treatments. In the light of this new concept of pain mechanisms, future pharmacologic treatment options may encompass a wider scope than the use of traditional analgesics and nonsteroidal anti-inflammatory drugs. There is currently limited experience for use of pharmacologic treatments that act primarily on neurogenic mechanisms in rheumatic conditions. Drug combination studies are lacking, but this strategy seems clinically reasonable to allow for an approach to treating pain from different mechanistic perspectives. An added advantage would be the opportunity to use lower doses of individual drugs and thereby reduce the side effect profile. Ideal pain management must also include attention to the important co-associates of pain such as effects on sleep, mood and energy, which all have an impact on the global burden of suffering. Although complete relief of pain is still an unrealistic objective, reasonable outcome goals for symptom relief should be accompanied with an improvement in function. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
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- View/download PDF
44. Chiropractic treatment for fibromyalgia: a systematic review.
- Author
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Ernst, Edzard
- Subjects
- *
FIBROMYALGIA , *RHEUMATISM , *CLINICAL trials , *MEDICAL research , *CHIROPRACTIC - Abstract
Many patients use chiropractic as a treatment of fibromyalgia, and many chiropractors seem to be convinced that it is effective for that condition. The aim of the study was to conduct a systematic review of randomised clinical trials testing the effectiveness of chiropractic care for fibromyalgia. Six electronic literature searches were conducted. No language restrictions were applied. Data extraction and validation were carried out by two independent reviewers. Three studies met the inclusion criteria. Their methodological quality was poor. They generated no evidence to suggest that chiropractic care is effective for fibromyalgia. Currently, there is insufficient evidence to conclude that chiropractic is an effective treatment for fibromyalgia. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
45. A clinical surrogate model for proof of efficacy of external phytomedicines for muscle pain. Results of a randomized, placebo-controlled clinical study in volunteers with muscle pain due to physical training.
- Author
-
Uehleke, Bernhard and Stange, Rainer
- Abstract
Abstract: Purpose: Surrogate models have been postulated for (re-)registration of external remedies for pain, whose active substances are in accordance to monographs. In a new human model, we investigated an ointment consisting of high dosed herbal ingredients. Methods: We conducted a clinical study in 32 healthy volunteers. Four muscle regions were treated with the ointments (verum on the one side and placebo on the other) in a randomized and doubleblinded manner immediately after a standardized physical exercise with individual intensity, as well as after 1, 2 and 24h. Acute muscle pain and muscle tension for each region was documented repeatedly during the following two days by visual analogue scale (VAS). Primary outcome parameter was the difference of pain during the follow up given as area under the curve (AUC) of VAS for corresponding right and left regions, treated with verum or placebo. Also the difference of muscle tension was documented and evaluated in an analogous way. Results: 30 out of 32 included patients finished the study, but developed only moderate muscle pain, with highest pain scores for extension muscles of the arm. There was less pain in the course for the verum in 3 of the 4 regions, the mean difference of individual AUCs was at highest for the extension (triceps) muscles of the arm, but between-group differences failed significance. Feeling of muscle tension was higher than that of pain, with smaller mean AUCs of verum in all 4 regions; the differences were significant in total (p<0.02) and in 2 of 4 single regions. Conclusions: Physical exercise was not intensive enough to exert clear symptoms. Our volunteers with sportive background seem not to show severe symptoms of muscle pain and muscle tension even after an intensive training. Despite low levels of symptoms, verum showed better courses of muscle tension and muscle pain. For future studies it seems better not to use volunteers with sportive background but totally untrained persons in order to achieve pronounced symptoms. The model is feasible, sensitive, inexpensive and is much more clinically relevant than those, focusing on perfusion parameters of skin. [Copyright &y& Elsevier]
- Published
- 2009
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- View/download PDF
46. Ruta graveolens, a useful homeopathic medicine for musculoskeletal disorders
- Author
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Alain Sarembaud
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Ruta graveolens ,Alternative medicine ,Homeopathic therapy ,Homeopathic medicine ,biology.organism_classification ,Professional activity ,03 medical and health sciences ,0302 clinical medicine ,Complementary and alternative medicine ,medicine ,Physical therapy ,Rheumatic pain ,030212 general & internal medicine ,business ,030217 neurology & neurosurgery - Abstract
Summary The increasing number of patients suffering from tendon and muscle injuries, especially in the course of their professional activity, continues to grow. These pains are often part of the syndrome of musculoskeletal disorders (MSDs). To treat those affected, homeopathic therapy has a number of suitable medications, including Ruta graveolens.
- Published
- 2017
47. Symptoms of depression and anxiety in functionally disabled rheumatic pain patients.
- Author
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V&aeliz;røy, Henning, Tanum, Lars, Bruaset, Helga, Mørkrid, Lars, and Førre, Øystein
- Subjects
- *
MENTAL depression , *ANXIETY , *SYMPTOMS , *RHEUMATISM , *PATIENTS , *PATHOLOGICAL psychology - Abstract
The aim of the present work was to study correlations between self-assessment of symptoms of depression, anxiety, rheumatic pain and functional disability. One hundred patients admitted to a university rheumatology clinic were tested in a consecutive manner, applying the Hospital Anxiety and Depression Scale (HADS). In addition, the patients were asked to express a quantitative measure of their subjective pain and functional disability on visual analogue scales (VAS). Regression analysis (analysis of variance) showed significant correlation between rheumatic pain and depression (P=0.04), between rheumatic pain and anxiety (P=0.03) and between rheumatic pain and functional disability (P<0.000). Significant correlations were also seen between depressive symptoms and functional disability (P=0.01) and between anxiety and functional disability (P=0.002). The correlation between symptoms of anxiety and depression was at a P=0.000 level. Applying the experience from this study and introducing, as part of a clinical examination, a minimum of psychiatric investigation based on self-assessment of anxiety and depression will provide relevant and reliable information sufficient for following up with specific psychiatric investigations and therapy. This in turn will be positive for those of the rheumatic patients having a comorbid mental health problem. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
48. Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats
- Author
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Sato, Jun, Aoyama, Morihiko, Yamazaki, Masahiro, Okumura, Satoshi, Takahashi, Ken, Funakubo, Megumi, and Mizumura, Kazue
- Subjects
- *
METEOROLOGY , *PAIN management , *ARTHRITIS , *BONE diseases - Abstract
To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund''s adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7 °C lower than 22 °C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
49. Cannabis for rheumatic pain: hope or hype?
- Author
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Mary-Ann Fitzcharles, Glen S Hazlewood, and Omid Zahedi Niaki
- Subjects
medicine.medical_specialty ,biology ,business.industry ,MEDLINE ,Cannabinol ,General Medicine ,biology.organism_classification ,Rheumatology ,Internal medicine ,Rheumatic Diseases ,Medicine ,Rheumatic pain ,Humans ,Cannabis ,Chronic Pain ,business ,Psychiatry - Published
- 2019
50. Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau
- Author
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Wei-Guo Cao, Chao Yu, Dan Zhang, Ling Yao, Yanduo Tao, Zhuo Chen, and Jia-Jia Guo
- Subjects
Formalin Test ,Antioxidant ,medicine.medical_treatment ,Analgesic ,Pharmaceutical Science ,01 natural sciences ,Analytical Chemistry ,lcsh:QD241-441 ,03 medical and health sciences ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Liquid chromatography–mass spectrometry ,formalin test ,Drug Discovery ,medicine ,Rheumatic pain ,Phenols ,Physical and Theoretical Chemistry ,030304 developmental biology ,Incarvillea compacta ,0303 health sciences ,Traditional medicine ,010401 analytical chemistry ,Organic Chemistry ,analgesia ,0104 chemical sciences ,LC-MS ,Tibetan plant ,Phytochemical ,chemistry ,Chemistry (miscellaneous) ,Molecular Medicine ,anti-oxidation - Abstract
Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry and quantitative analyses of the total phenols, flavonoids, and alkaloids content of different extracts of I. compacta Maxim. Antioxidant and analgesic activity were analyzed. The results showed that the methanol extract had the highest content of the various ingredients. A total of 25 constituents were identified, of which compounds 1&ndash, 23 were found for the first time in this plant. The water extract had the highest capacity to clear free radicals in the antioxidant test. The water extract had dose-dependent analgesic effects in the first and second phase in a formalin test. The latency of pain from a hot-plate test was augmented by the water extract when the dose was greater than or equal to 30 g/kg. The water extract significantly decreased the amount of writhing in a dose-dependent manner compared with the control group in the acetic acid-induced writhing test. These results showed that I. compacta Maxim is a new antioxidant and analgesic agent, and this study provides information on its ingredients for further study.
- Published
- 2019
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