1. IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.
- Author
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Sousa LM, Carneiro MB, Dos Santos LM, Natale CC, Resende ME, Mosser DM, and Vieira LQ
- Subjects
- Animals, Disease Susceptibility, Interleukin-18 genetics, Leishmaniasis genetics, Leishmaniasis pathology, Macrophages immunology, Macrophages pathology, Mice, Mice, Knockout, Receptors, Interleukin-18 genetics, Receptors, Interleukin-18 immunology, Interleukin-18 immunology, Leishmania immunology, Leishmaniasis immunology
- Abstract
We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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