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IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.
- Source :
-
Cytokine [Cytokine] 2015 Aug; Vol. 74 (2), pp. 327-30. Date of Electronic Publication: 2015 May 23. - Publication Year :
- 2015
-
Abstract
- We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Disease Susceptibility
Interleukin-18 genetics
Leishmaniasis genetics
Leishmaniasis pathology
Macrophages immunology
Macrophages pathology
Mice
Mice, Knockout
Receptors, Interleukin-18 genetics
Receptors, Interleukin-18 immunology
Interleukin-18 immunology
Leishmania immunology
Leishmaniasis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0023
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 26009021
- Full Text :
- https://doi.org/10.1016/j.cyto.2015.01.021