IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.

Authors :: Sousa LM
Carneiro MB
Dos Santos LM
Natale CC
Resende ME
Mosser DM
Vieira LQ
Source :: Cytokine [Cytokine] 2015 Aug; Vol. 74 (2), pp. 327-30. Date of Electronic Publication: 2015 May 23.
Publication Year :: 2015
Abstract: We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Disease Susceptibility
Interleukin-18 genetics
Leishmaniasis genetics
Leishmaniasis pathology
Macrophages immunology
Macrophages pathology
Mice
Mice, Knockout
Receptors, Interleukin-18 genetics
Receptors, Interleukin-18 immunology
Interleukin-18 immunology
Leishmania immunology
Leishmaniasis immunology

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