1. Effects of MSG supplementation on free amino acids in plasma of growing-finishing Pigs
- Author
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Zhang, Jun, Yin, Yulong, He, Qinghua, Chen, Gang, Li, Tiejun, Wu, Xiaosong, Nyachoti, Martin, Blachier, Francois, Wang, Yongfei, Wen, Qingqi, Sci Oberving & Expt Stn Anim Nutr & Feed Sci S Ce, Inst Subtrop Agr,Res Ctr Hlth Breeding Livestock, Hunan Engn & Res Ctr Anim & Poultry Sci,Key Lab, Chinese Academy of Sciences [Changchun Branch] (CAS), Coll Anim Sci & Technol, Hunan Agricultural University [Changsha], Dept Anim Sci, University of Manitoba [Winnipeg], Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Ctr Res & Dev, Twins Grp Co Ltd, National Basic Research Program of China [2013CB127301, 2012CB124704], National Natural Science Foundation of China [31110103909, 30901040, 30928018, 31101729], National Scientific and Technology Support Project [31272463], Chinese Academy of Sciences [2011T2S15], and Institut National de la Recherche Agronomique (INRA)-AgroParisTech
- Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,aspartate ,AMMONIA ,pigs ,peritoneal perfusion ,glutamate ,METABOLISM ,MONOSODIUM GLUTAMATE ,nutrition ,DIGESTION ,ABSORPTION ,SKELETAL-MUSCLE ,alanine ,MSG - Abstract
Glutamate is extensively metabolized in small intestine epithelial cells during its transcellular transfer from the lumen to bloodstream and after its uptake from the bloodstream. In order to study the effect of monosodium glutamate (MSG) supplementation given either by the parenteral route or by the enteral route on the circulating amino acid concentrations in growing-finishing pigs, animals received MSG at a dose equal to 0.25 g/kg body weight by intraperitoneal injection or by injection into the stomach. Up to 255 min, arterial and portal venous blood was collected and amino acid concentrations were measured. The results show that the glutamate concentrations in venous and arterial plasma increase rapidly after injection of MSG in stomach. However, glutamate concentration in both venous and arterial plasma was much higher after peritoneal than stomach injection. Aspartate and alanine concentrations in both venous and arterial plasma were higher after stomach than peritoneal injection. The results obtained are compatible with the view that i) a large part of glutamate in MSG is metabolized by the intestine in pigs; ii) at the dose used. MSG is, however, not entirely metabolized by the intestine and iii) glutamate metabolism in pig intestine leads to aspartate and alanine production.
- Published
- 2012