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163 results on '"Ren, Ru-Jing"'

1. Recommendations for the clinical use of anti ⁃ Aβ monoclonal antibody for Alzheimer's disease (2024)

Author

WANG Gang, LI Bin‑yin, REN Ru‑jing, XIAO Jin‑wen, CHEN Sheng‑di, and CHEN Xiao‑chun

Subjects
alzheimer disease, amyloid beta ‑ peptides, antibodies, monoclonal, diagnostic and treatment guideline, review, Neurology. Diseases of the nervous system, RC346-429
Abstract

Several anti‑Aβ monoclonal antibody drugs have been approved for clinical use at home and abroad recently. In order to facilitate its safe and effective treatment of anti‑Aβ monoclonal antibody drugs for Alzheimer's disease (AD) in China, we present recommendations for the clinical use of anti‑Aβ monoclonal antibody drugs based on existing clinical trials and the clinical practice of AD treatment with Aducanumab at Ruijin Hospital Hainan Branch, Shanghai Jiaotong University School of Medicine. The recommendations include clinical indications, pre ‑ medication assessment and preparation, medication instructions and precautions, as well as post ‑ medication clinical monitoring, which is aimed to furnish clinicians with comprehensive medication guidance.

Published
2024
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4. The ethical issues of patients with Alzheimer's disease during their lifetime

Author

WANG Jin⁃tao, REN Ru⁃jing, and WANG Gang

Subjects
alzheimer disease, ethics medical, advance directives, hospice and palliative care nursing, automobile driving, review, Neurology. Diseases of the nervous system, RC346-429
Abstract

Alzheimer's disease (AD) is a chronic progressive degenerative disease with gradually decreasing cognition. Because of the high prevalence, heavy social burden and wide interaction with others, the ethical issues are increasingly prominent. This article focuses on the details, such as disclosing diagnosis, breaking bad news, advance directives, hospice care and palliative care, and driving. From these issues, as a medical staff, we should know and respect our patients and their families sufficiently. We should make a reasonable treatment with patients and their families for a better outcome. At the same time, more propaganda about advance directives and hospice care should be taken for a healthier perception. doi:10.3969/j.issn.1672⁃6731.2021.04.005

Published
2021
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12. Additional file 1 of Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study

Author

Wang, Hua-Long, Tang, Ran, Ren, Ru-Jing, Dammer, Eric B., Guo, Qi-Hao, Peng, Guo-Ping, Cui, Hai-Lun, Zhang, You-Min, Wang, Jin-Tao, Xie, Xin-Yi, Huang, Qiang, Li, Jian-Ping, Yan, Fu-Hua, Chen, Sheng-Di, He, Na-Ying, and Wang, Gang

Abstract

Additional file 1: Supplemental Figure 1. fMRI task paradigm. Supplemental Figure 2. Group difference in the Semantic Fluency-Fixation contrasts and its behavioral significance. One-way ANOVA, cluster-level P < 0.05, FWE corrected. Supplemental Table 1. The Post-hoc comparisons of the clinical characteristics in the China RSF multi-center cohort (Bonferroni corrected). Supplemental Table 2. Clinical characteristics of NC and AD patients in the Pitt center cohort. Supplemental Table 3. Correlation between PSD and cognition. Supplemental Table 4. The linear regression analysis of the variables correlated with PSD after adjusting for age. Supplemental Table 5. Demographic and neuropsychological/language characteristics of fMRI participants. Supplemental Table 6. Significant clusters in three linguistic tasks showing different activation by ANOVA analysis. Supplemental Table 7. Results of correlation analysis. # The spearman correlation coefficients were calculated between the average BOLD signal and the relevant fluency score of ACE-III. * The partial correlation coefficients were calculated between the average BOLD signal and PSD in the patient group. Supplemental Table 8. Post hoc analysis of cluster activation. Bold indicated significance (Bonferroni corrected).

Published
2022
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15. The impacts of health insurance and resource on the burden of Alzheimer's disease and related dementias in the world population.

Author

Wang, Jin‐Tao, Xu, Gang, Ren, Ru‐Jing, Wang, Ying, Tang, Ran, Huang, Qiang, Li, Jian‐Ping, Al‐Nusaif, Murad, Le, Wei‐Dong, and Wang, Gang

Abstract

Introduction: The increasing prevalence of Alzheimer's disease and related dementias (ADRD) presents both a burden and an opportunity for intervention. This study aims to estimate the impacts of health insurance and resources on the burden attributed to ADRD. Method: Data were mainly collected from global databases for ADRD. Analysis of variance, Pearson correlation, random‐effects, and fixed‐effects model analyses were used in this study. Results: Although the current medical expenditures were increasing and out of pocket (OOP) expenditures were declining generally in various countries, the collected global data showed an increased burden of ADRD on patients both physically and economically. Furthermore, health resources were negatively associated with disability‐adjusted life years (DALY), death, and years of life lost (YLL), but were otherwise positively associated with years of life lived with disability (YLD). Discussion: Effective measures should be considered to cope with the rising burden. Meanwhile, there is an urgent call for constructive and sustainable rational plans and global collaboration. Highlights: We explored how health insurance and resources affect Alzheimer's disease and related dementias (ADRD)‐related burden.Health insurance and resources were imbalanced among four income level groups.Health insurance and resources may decrease the total ADRD burden primarily from a reduction in death‐related burden.Health insurance and resources may increase disability‐related burden. [ABSTRACT FROM AUTHOR]

Published
2023
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16. microRNA‐425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies

Author

Hu, Yong‐Bo, primary, Zhang, Yong‐Fang, additional, Ren, Ru‐Jing, additional, Dammer, Eric B., additional, Xie, Xin‐Yi, additional, Chen, Shi‐Wu, additional, Huang, Qiang, additional, Huang, Wan‐Ying, additional, Zhang, Rui, additional, Chen, Hong‐Zhuan, additional, Wang, Hao, additional, and Wang, Gang, additional

Published
2021
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20. Additional file 2 of Opinions and clinical practice of functional movement disorders: a nationwide survey of clinicians in China

Author

Xie, Xin-Yi, Lin, Guo-zhen, Huang, Qiang, Li, Chun-Bo, Hallett, Mark, Voon, Valerie, Ren, Ru-jing, Chen, Sheng-di, and Wang, Gang

Subjects
cardiovascular system
Abstract

Additional file 2: Fig. S1. Demographic information of the respondents. Fig. S2. Findings necessary for clinically definite diagnosis of FMD. Fig. S3. Suggestion or placebo used in documenting and diagnosing FMD. Fig. S4. Refer patients for treatment.

Published
2021
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26. Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in Shanghai, China.

Author

Ren, Ru‐Jing, Huang, Qiang, Xu, Gang, Gu, Kai, Dammer, Eric B., Wang, Chun‐Fang, Xie, Xin‐Yi, Chen, Wen, Shao, Zhen‐Yi, Chen, Sheng‐Di, and Wang, Gang

Abstract

Introduction: We investigated the association between Alzheimer's disease (AD) and the risk of cancer in the Chinese population. Methods: In this retrospective cohort study, multivariate Cox proportional hazard regression analysis was used to determine the correlation between AD and the risk of various cancers, as shown by hazard ratios (HRs) with 95% confidence intervals (CIs). Results: Of 8097 AD patients, the HR for all subsequent cancers was 0.822 (95% CI, 0.728‐0.928; P =.002). Among them, three specific cancers were associated with AD: lung cancer (HR, 0.656; 95% CI, 0.494‐ 0.871; P =.004), prostate and testicular cancer (HR, 0.414; 95% CI, 0.202‐0.847; P =.016), and lymphoma (HR, 2.202; 95% CI, 1.005‐4.826; P =.049). Conclusion: Patients with AD might have a lower chance of developing several cancers, including lung cancer and prostate and testicular cancer. Meanwhile, a positive association between AD and a higher incident rate of lymphoma was observed. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Rho‐associated coiled‐coil kinase 1 activation mediates amyloid precursor protein site‐specific Ser655 phosphorylation and triggers amyloid pathology

Author

Hu, Yong‐Bo, primary, Ren, Ru‐Jing, additional, Zhang, Yong‐Fang, additional, Huang, Yue, additional, Cui, Hai‐Lun, additional, Ma, Chao, additional, Qiu, Wen‐Ying, additional, Wang, Hao, additional, Cui, Pei‐Jing, additional, Chen, Hong‐Zhuan, additional, and Wang, Gang, additional

Published
2019
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39. Mortality of Alzheimer’s Disease Patients: A 10-Year Follow-up Pilot Study in Shanghai

Author

Zhang, Yue-Qi, Wang, Chun-Fang, Xu, Gang, Zhao, Qian-Hua, Xie, Xin-Yi, Cui, Hai-Lun, Wang, Ying, Ren, Ru-Jing, Guo, Qi-Hao, and Wang, Gang

Abstract

ABSTRACT:Background:Identifying risk factors and mortality of individuals with Alzheimer’s disease (AD) could have important implications for the clinical management of AD.Objective:This pilot study aimed to examine the overall mortality of AD patients over a 10-year surveillance period in Shanghai, China. This study is an extension of our previous investigation on mortality of neurodegenerative diseases.Methods:One hundred and thirty-two AD patients recruited from the memory clinics of two hospitals in Shanghai in 2007 were followed up until December 31, 2017 or death, representing a follow-up period of up to 10 years. Overall standardized mortality ratios (SMRs) were calculated, and predictors for survival at recruitment were estimated.Results:Sixty-seven patients had died by December 31, 2017, and the SMR at 10 years of follow-up was 1.225 (95% confidence interval 0.944–1.563). Employing Cox’s proportional hazard modeling, lower Mini-Mental State Examination score, and comorbid diabetes predicted poor survival in this cohort.Conclusion:This pilot study suggests a similar survival trend of patients with AD compared to the general population in Shanghai urban region. Poor cognitive status and comorbid diabetes had a negative impact on the survival of AD patients.

Published
2020
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46. Diagnostic value and research progress of neuroimaging in Parkinson's disease and Parkinson-plus syndromes.

Author

CUI Hai-lun, REN Ru-jing, and WANG Gang

Subjects
PARKINSON'S disease diagnosis, DIFFERENTIAL diagnosis, MAGNETIC resonance imaging, NEURORADIOLOGY, POSITRON emission tomography, SINGLE-photon emission computed tomography
Abstract

As one of the indispensable means of medical examination, neuroimaging methods play a vital role in the diagnosis of Parkinson's disease (PD) and Parkinson - plus syndromes. The review summarized neuroimaging characteristics of PD and Parkinson - plus syndromes, and the application of structural MRI (sMRI), fMRI, PET and SPECT on diagnosis and differential diagnosis of related diseases and syndromes. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Mutation Screening of the CHCHD2 Gene for Alzheimer's Disease and Frontotemporal Dementia in Chinese Mainland Population.

Author

Xiang-Qian Che, Qian-Hua Zhao, Yue Huang, Xia Li, Ru-Jing Ren, Sheng-Di Chen, Qi-Hao Guo, Gang Wang, Che, Xiang-Qian, Zhao, Qian-Hua, Huang, Yue, Li, Xia, Ren, Ru-Jing, Chen, Sheng-Di, Guo, Qi-Hao, and Wang, Gang

Subjects
GENETICS of Alzheimer's disease, DEMENTIA, ALZHEIMER'S patients, DEMENTIA patients, NEURODEGENERATION, MITOCHONDRIA, GENETICS, ALZHEIMER'S disease, ASIANS, COMPARATIVE studies, GENETIC techniques, RESEARCH methodology, MEDICAL cooperation, GENETIC mutation, PROTEINS, RESEARCH, TRANSCRIPTION factors, EVALUATION research, CASE-control method, FRONTOTEMPORAL dementia
Abstract

As an important multifunctional protein involved in regulation of mitochondrial metabolism, CHCHD2 was identified as a causative gene for Parkinson's disease (PD), yet the relationship between CHCHD2 and neurodegenerative dementia is not well understood. We directly sequenced the entire coding region of CHCHD2 gene in 150 AD patients, 84 FTD patients, and 417 controls. Four rare putative pathogenic variants of CHCHD2, including rs142444896 (c.5C>T, p.P2L), rs752705344 (c.15C>G, p.S5R), rs145190179 (c.94G>A, p.A32T), and rs182992574 (c.255T>A, p.S85R) were identified from a cohort composed of 150 AD and 84 FTD patients. These results suggest that CH CHD2 gene play an important role in other neurodegenerative disorders from our dementia study in China. [ABSTRACT FROM AUTHOR]

Published
2018
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48. History, Present, and Progress of Frontotemporal Dementia in China: A Systematic Review

Author

Ren, Ru-Jing, Huang, Yue, Xu, Gang, Li, Chun-Bo, Cheng, Qi, Chen, Sheng-Di, and Wang, Gang

Subjects
Article Subject, mental disorders, nutritional and metabolic diseases, nervous system diseases
Abstract

We aim to provide an overview of clinical and demographical features and neuropathological research on frontotemporal dementia (FTD) from China over the past decade. We reviewed the demographic features, clinical presentations, and neuropathology of the FTD-spectrum disorders from the 49 cases in China published since 1998. On the basis of these findings, we retrospect the history and speculate on future progress in terms of FTD in China. We found that most published papers comprise case reports with a few retrospective studies with small sample sizes. Behavior variant FTD (bvFTD) was the most common diagnostic subtype, of which 35% were associated with amyotrophic lateral sclerosis or Parkinsonian syndrome. More than 47% patients with FTD had age onset before 65. There were no differences in age of onset and sex distribution between diagnostic subtypes. The spectrum of neuropathological diagnosis of bvFTD was frontotemporal lobe degeneration (FTLD) with tau protein or ubiquitin-immunopositive inclusions, and FTLD without intracellular inclusions. Median survival in bvFTD was 14 years. This paper provides an overview of the current status and pointers for future research directions of FTD in China.

Published
2012
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49. Peripheral Blood MicroRNA Expression Profiles in Alzheimer’s Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism

Author

Ren, Ru-Jing, primary, Zhang, Yong-Fang, additional, Dammer, Eric B., additional, Zhou, Yi, additional, Wang, Li-ling, additional, Liu, Xiao-Hong, additional, Feng, Bei-Lei, additional, Jiang, Guo-Xin, additional, Chen, Sheng-Di, additional, Wang, Gang, additional, and Cheng, Qi, additional

Published
2015
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