Additional file 1 of Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study

Additional file 1: Supplemental Figure 1. fMRI task paradigm. Supplemental Figure 2. Group difference in the Semantic Fluency-Fixation contrasts and its behavioral significance. One-way ANOVA, cluster-level P < 0.05, FWE corrected. Supplemental Table 1. The Post-hoc comparisons of the clinical characteristics in the China RSF multi-center cohort (Bonferroni corrected). Supplemental Table 2. Clinical characteristics of NC and AD patients in the Pitt center cohort. Supplemental Table 3. Correlation between PSD and cognition. Supplemental Table 4. The linear regression analysis of the variables correlated with PSD after adjusting for age. Supplemental Table 5. Demographic and neuropsychological/language characteristics of fMRI participants. Supplemental Table 6. Significant clusters in three linguistic tasks showing different activation by ANOVA analysis. Supplemental Table 7. Results of correlation analysis. # The spearman correlation coefficients were calculated between the average BOLD signal and the relevant fluency score of ACE-III. * The partial correlation coefficients were calculated between the average BOLD signal and PSD in the patient group. Supplemental Table 8. Post hoc analysis of cluster activation. Bold indicated significance (Bonferroni corrected).