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1. Poster session 6: Saturday 6 December 2014, 08: 30–12: 30Location: Poster area

Author: Tierens, S, Remory, I, Bala, G, Gillis, K, Hernot, S, Droogmans, S, Cosyns, B, Lahoutte, T, Tran, N, and Poelaert, J
Published: 2014

2. Club35 Poster Session Thursday 12 December: 12/12/2013, 08: 30–18: 00Location: Poster area

Author: Gillis, K, Bala, G, Roosens, B, Remory, I, Droogmans, S, Van Camp, G, and Cosyns, B
Published: 2013

3. Assessment of intraoperative microaspiration: does a modified cuff shape improve sealing?

Author: DʼHAESE, J., De Keukeleire, T., Remory, I., Van Rompaey, K., Umbrain, V., and Poelaert, J.
Published: 2013
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4. Rapid Fire Abstract: Multimodality imaging valvular heart disease742Quantification of aortic regurgitation by pulsed Doppler examination of the left subclavian artery velocity contour: a validation study with cardiac magnetic resonance imaging743Diastolic retrograde flow in the descending aorta by cardiovascular magnetic resonance imaging for the quantification of aortic regurgitation744Native T1 relaxation time can accurately identify limited left ventricular contractile reserve in patients with aortic stenosis745The validation and assessment of myocardial fibrosis by using cardiac magnetic resonance and speckle-tracking echocardiography in severe aortic stenosis746Clinical validation of a semi-automatic quantification score of aortic valve calcification with ultrasound747A comparison among conventional 3D-transesophageal echocardiography manual analysis, 3D automatic software analysis and computed tomography for the aortic annulus sizing in TAVI patients748New insights from a multimodality imaging evaluation of LV remodeling in patients with chronic ischemic mitral regurgitation: a combined magnetic resonance and speckle tracking analysis749Multimodality imaging monitoring during percutaneous tricuspid valve repair procedures

Author: Spampinato, RA., primary, Kammerlander, A., primary, Ondrus, T., primary, Cho, SW., primary, Gillis, K., primary, Italia, L., primary, Zito, C., primary, Ancona, F., primary, Jahnke, C., additional, Paetsch, I., additional, Hilbert, S., additional, Schloma, V., additional, Dmitrieva, Y., additional, Strotdrees, E., additional, Hindricks, G., additional, Mohr, FW., additional, Wiesinger, M., additional, Duca, F., additional, Aschauer, S., additional, Zotter-Tufaro, C., additional, Schwaiger, ML., additional, Marzluf, BA., additional, Bartko, PE., additional, Bonderman, D., additional, Mascherbauer, J., additional, Mirica, DC., additional, Kotrc, M., additional, Kockova, R., additional, Van Camp, G., additional, Mo, Y., additional, Praveckova, A., additional, Penicka, M., additional, Park, SJ., additional, Kim, SM., additional, Hwang, JW., additional, Chang, SA., additional, Jeong, DS., additional, Lee, SC., additional, Park, SW., additional, Choe, YH., additional, Park, PW., additional, Bala, G., additional, Roosens, B., additional, Hernot, S., additional, Remory, I., additional, Droogmans, S., additional, Cosyns, B., additional, Geremia, G., additional, Stella, S., additional, Marini, C., additional, Rosa, I., additional, Ancona, F., additional, Latib, A., additional, Montorfano, M., additional, Colombo, A., additional, Margonato, A., additional, Agricola, E., additional, Bracco, A., additional, Baldi, E., additional, Di Bella, G., additional, Cusma Piccione, M., additional, Di Nunzio, D., additional, Donato, R., additional, Manganaro, R., additional, Terrizzi, A., additional, Pizzino, F., additional, Carerj, ML., additional, Rivetti, L., additional, Bitto, R., additional, Sergi, M., additional, Carerj, S., additional, Spartera, M., additional, Denti, P., additional, Hahn, R., additional, and Alfieri, O., additional
Published: 2016
Full Text: View/download PDF

5. Poster session 5The imaging examinationP1097Correlation between visual and quantitative assessment of left ventricle: intra- and inter-observer agreementP1099Incremental prognostic value of late gadolinium-enhanced by cardiac magnetic resonance in patients with heart failureAnatomy and physiology of the heart and great vesselsP1100Left ventricular geometry and diastolic performance in erectile dysfunction patients; a topic of differential arterial stiffness influenceAssessment of diameters, volumes and massP1101Impact of the percutaneous closure of atrial septal defect on the right heart "remodeling"P1102Left Ventricular Mass Indexation in Infants, Children and Adolescents: a Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical PracticeP1103Impact of trabecules while quantifying cardiac magnetic resonance exams in patients with systemic right ventricleP1104Detection of subclinical atherosclerosis by carotid intima-media thickness: correlation with leukocytes telomere shorteningAssessments of haemodynamicsP1105Flow redirection towards the left ventricular outflow tract: vortex formation is not affected by variations in atrio-ventricular delayAssessment of systolic functionP1106Reproducibility and feasibility of cardiac MRI feature tracking in Fabry diseaseP1107Normal left ventricular strain values by two-dimensional strain echocardiography; result of normal (normal echocardiographic dimensions and functions in korean people) studyP1108Test-retest repeatability of global strain following st-elevation myocardial infarction - a comparison of tagging and feature trackingP1109Cardiotoxicity induced by tyrosine kinase inhibitors in patients with gastrointestinal stromal tumors (GIST)P1110Finite strain ellipses for the analysis of left ventricular principal strain directions using 3d speckle tracking echocardiographyP1111Antihypertensive therapy reduces time to peak longitudinal strainP1112Right ventricular systolic function as a marker of prognosis after inferior myocardial infarction - 5-year follow-upP1113Is artery pulmonary dilatation related with right but also early left ventricle dysfunction in pulmonary artery hypertension?P1114Right ventricular mechanics changes according to pressure overload increasing, a 2D-speckle tracking echocardiographic evaluationAssessment of diastolic functionP1115Paired comparison of left atrial strain from P-wave to P-wave and R-wave to R-waveP1116Diagnostic role of Tissue Doppler Imaging echocardiographic criteria in obese heart failure with preserved ejection fraction patientsP1117Evaluation of diastolic function of right ventricle in idiopathic pulmonary arterial hypertensionP1118Severity and predictors of diastolic dysfunction in a non-hypertensive non-ischemic cohort of Egyptian patients with documented systemic autoimmune disease; pilot reportP1119correlation between ST segment shift and cardiac diastolic function in patients with acute myocardial infarctionIschemic heart diseaseP1120Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)P1121Utility of transmural myocardial mechanic for early infarct size prediction after primary percutaneous coronary intervention in STEMI patientsP1122Progressive Improvements of the echocardiographic deformation parameters in ST Elevation Myocardial Infarction after five years follow-upP1123Long-term prognostic value of left ventricular dyssynchrony as assessed by cardiac magnetic resonance feature-tracking imaging after a first st-segment elevation myocardial infarctionP1124Differences in mitral annulus remodeling in acute anterior ST elevation and acute inferior ST elevation myocardial infarctionP1125Reduction of microvascular injury using a novel theragnostic ultrasound strategy: a first in men feasibility and safety studyP1126Impact of focused echocardiography in clinical decision of patient presented with st elevation myocardial infarction underwent primary angioplastyHeart valve DiseasesP1127Aortic valve area calculation in aortic stenosis: a comparison among conventional and 3D-transesophageal echocardiography and computed tomographyP1128Myocardial fibrosis and microRNA-21 expression in patients with severe aortic valve stenosis and preserved ejection fraction: a 2D speckle tracking echocardiography, tissutal and plasmatic studyP1129Quantification of calcium amount in a new experimental model: a comparison between calibrated integrated backscatter of ultrasound and computed tomographyP1130Altered diffusion capacity in aortic stenosis: role of the right heartP1131Osteoprotegerin predicts all-cause mortality in calcific aortic stenosis patients with preserved left ventricle ejection fraction in long term observationP1132Mitral regurgitation as a risk factor for pulmonary hypertension in patients with aortic stenosisP1133The relationship between the level of plasma B-type natriuretic peptide and mitral stenosisP1134Aortic regurgitation, left ventricle mechanics and vascular load: a single centre 2d derived-speckle tracking studyP1135Feasibility and reproducibility issues limit the usefulness of quantitative colour Doppler parameters in the assessment of chronic aortic and mitral regurgitation severityP1136Predictors of postoperative outcome in degenerative mitral regurgitationP1137Left ventricular mechanical dyssynchrony in patients with severe mitral regurgitation of rheumatic etiology; three dimensional echocardiography studyP1138Functional mitral regurgitation and left atrial dysfunction concur in determining pulmonary hypertension and functional status in subjects with left ventricular systolic dysfunctionP11393D echocardiography allows more effective quantitative assessment of the severity of functional tricuspid regurgitation than conventional 2D/Doppler echocardiographyP1140Prosthetic valve thrombosis: still a severe disease? 10-years experience in a university hospitalP1141Validity of echocardiography in the hospital course of patients with feverP1142Do baseline 3DTEE characteristics of mitral valve apparatus predict long term result in patients undergoing percutaneous valve repair for degenerative regurgitation?P1143Influence of baseline aortic regurgitation on mitral regurgitation change after transcatheter aortic valve replacement for aortic stenosisP1144Prevalence of echocardiography detected significant valvular regurge in subclinical rheumatic carditis in assiut childrenCardiomyopathiesP1145Can we early detect left ventricular systolic dysfunction in patients with Duchenne muscular dystrophy using global longitudinal strain assessment?P1146Prevalence of isolated papillary muscle hypertrophy in young competitive athletesP1147Troponin release after exercise in patients with hypertrophic cardiomyopathy: associations with clinical and mr imaging characteristicsP1148Atrial fibrillation in hypertrophic cardiomyopathy: can we score the risk?P1149Impact of hypertrophy on multiple layer longitudinal deformation in hypertrophy cardiomyopathy and cardiac amyloidosis compared to controlsP1150Functional evaluation in hypertrophic cardiomyopathy combining cardiopulmonary exercise testing combined with exercise-echocardiographyP1151Refinement of the old diagnostic criteria of left ventricular noncompaction cardiomyopathy (LVNC) based on cardiac magnetic resonance (CMR)P1152Differences of clinical characteristics and outcomes between acute myocarditis with preserved and reduced left ventricular systolic functionP1153Value of longitudinal strain for distinguishing left ventricular non-compaction from idiopathic dilated cardiomyopathyP1154Speed of recovery of left ventricular function is not related to the prognosis of Takotsubo cardiomyopathy. A Portuguese multicentre studyP1155Predictors of in-hospital left ventricular systolic function recovery after admission with takotsubo cardiomyopathy. Portuguese multicentre studyP1156Mid-ventricular takotsubo detected by initial echocardiogram associates with recurrence of takotsubo cardiomyopathy - a portuguese multicentre studySystemic diseases and other conditionsP1157Relations between left ventricle remodelling and expression of angiotensin 2 AT2R1 geneP1158Impact of renal denervation on long-term blood pressure variability and surrogate markers of target organ damage in individuals with drug-resistant arterial hypertensionP1159Greater improvement of coronary artery function, left ventricular deformation and twisting by IL12/23 compared to TNF-a inhibition in psoriasisP1160Advanced glycation end products play a role in adverse LV remodeling following MIP1161Incidence of subclinical myocardial dysfunction in patients with systemic sclerosis and normal left ventricular systolic and diastolic functionP1162Left atrial remodeling and dysfunction occur early in patients with systemic sclerosis and normal left ventricular functionP1163Intrinsic vortex formation : a unique performance indicatorP1164P-wave morphology is unaffected by training-induced biatrial dilatation: a prospective, longitudinal study in healthy athletesP1165Usefulness of transthoracic echocardiography in diagnosis of young patients with ischemic strokeP1166Primary cardiac lymphoma: role of echocardiography in the clinical managementP1167Abnormal echocardiographic findings in cancer patients before chemotherapyMasses, tumors and sources of embolismP1168Three-dimensional transesophageal echocardiography of the left atrial appendage reduces rate of postpone electrical cardioversionP1169Detection of ventricular thrombus by cmr after reperfused st-segment elevation myocardial infarction correlated with echocardiographyP1170Clinical and transthoracic echocardiographic predictors of left atrial appendage thrombus in patients with atrial fibrillationStress echocardiographyP1171Pharmacological stress echocardiography complications: a 4-year single center experienceP1172Myocardial functional and perfusion reserve in type I diabetesP1173Feasibility of incorporating 3D Dobutamine stress echocardiography into routine clinical practiceP1174Right ventricular isovolumic acceleration at rest and during exercise in children after heart transplantP1175Right ventricular systolic and diastolic response to exercise in children after heart transplant -a bicycle exercise studyP1176Determinants of functional capacity in heart failure patients with reduced ejection fractionP1177Handgrip stress echocardiography with emotional component compared to conventional isometric exercise in coronary artery disease diagnosisP1178The relationship between resting transthoracic echocardiography and exercise capacity in patients with paroxysmal atrial fibrillationP1179Correlation between NT-proBNP and selected echocardiography parameters at rest and after exercise in patients with functional ischemic mitral regurgitation qualified for cardiosurgical treatmentReal-time three-dimensional TEEP1180Vena contracta area for severity grading in functional and degenerative mitral regurgitation: A study based on transesophageal 3D colour Doppler in 419 patientsP1181Proximal flow convergence by 3D echocardiography in the evaluation of mitral valve area in rheumatic mitral stenosisP1182Quantification of valve dimensions by transesophageal 3D echocardiography in patients with functional and degenerative mitral regurgitationTissue Doppler and speckle trackingP1183Automatic calculation of left ventricular volume changes over a cardiac cycle from echocardiography images by nonlinear dimensionality reductionP1184Effect of the mitral valve repairs on the left ventricular blood flow formationP1185Quantification of left atrial strain using cardiovascular magnetic resonance. a comparison between hypertrophic cardiomyopathy and healthy controlsP1186The role of early systolic lengthening in patients with non-ST elevation acute coronary syndrome and its relation to syntax scoreP1187Different standard two dimensional strain methods to quantity left ventricular mechanicsP1188Atrial function and electrocardiography caracteristics in sportsmen with or without paroxysmal atrial fibrillationP1189Right ventricular outflow premature contractions induce regional left ventricular dysfunctionP1190Ultrasound guided venous access for pacemaker and defibrillators. Randomized TrialP1191Atrial function analysis correlates with symptoms and quality of life of heart failure patientsP1192The use of tissue doppler echocardiography in myocardial iron overload in patients with thalassaemia majorP1193Independent association between pulse pressure and left ventricular global longitudinal strainP1194Global and regional longitudinal strain identifies the presence of coronary artery disease in patients with suspected reduction of coronary flow reserve and absence of wall motion abnormalitiesP1195Prognostic value of invasive and noninvasive parameters of right ventricular function in patients with pulmonary arterial hypertension receiving specific vasodilator therapyP1196Myocardial deformation analysis to improve arrhythmic risk stratificationP1197Quantitative assessment of regional systolic and diastolic function parameters for detecting prior transient ischemia in normokinetic segmentsP1198Left atrial function in patients with corrected tetralogy of Fallot - a three-dimensional speckle-tracking echocardiographic studyP1199Left atrial ejection force correlates with left atrial strain and volume-based functional properties as assessed by three-dimensional speckle tracking echocardiographyP1200Acute angulation of the aortic arch late after the arterial switch operation for transposition of the great arteries: impact on cardiac mechanicsP1201Circumferential deformation of the ascending thoracic aorta in hypertensive patients by three-dimensional speckle tracking echocardiographyCardiac Magnetic ResonanceP1202The incremental value of cardiac magnetic resonance on diagnosis myocardial infarction and non-obstructed coronary arteriesP1204Reference ranges of global and regional myocardial T1 values derived from MOLLI and shMOLLI at 3TComputed Tomography & Nuclear CardiologyP1205Deformation of the left atrial appendage after percutaneous closure with the Amplatzer cardiac plugP1206Prognostic impact of non-obstructive coronary artery disease on coronary computed tomographic angiography: A single-center study

Author: Colunga Blanco, S, primary, Gonzalez Matos, C, primary, Angelis, A, primary, Dinis, P G, primary, Chinali, M, primary, Toth, A, primary, Andreassi, M G, primary, Rodriguez Munoz, D, primary, Reid, A B, primary, Park, JH, primary, Shetye, A, primary, Novo, G, primary, De Marchi, S F, primary, Cikes, M, primary, Smarz, K, primary, Illatopa, V, primary, Peluso, D, primary, Wellnhofer, E, primary, De La Rosa Riestra, A, primary, Sattarzadeh Badkoubeh, R, primary, Mandour Ali, M, primary, Azoz, A, primary, Pontone, G, primary, Krljanac, G, primary, Acar, R, primary, Nucifora, G, primary, Sirtautas, A, primary, Roos, S T, primary, Qasem, M S, primary, Marini, C, primary, Fabiani, I, primary, Gillis, K, primary, Bandera, F, primary, Borowiec, A, primary, Lim, YJ, primary, Chalbia, T E, primary, Santos, M, primary, Gao, S A, primary, Zilberszac, R, primary, Farrag, AAM, primary, Palmiero, G, primary, Aruta, P, primary, De Diego Soler, O, primary, Fasano, D, primary, Tamborini, G, primary, Ancona, F, primary, Raafat, D M, primary, Marchel, M, primary, De Gregorio, C, primary, Gommans, D H F, primary, Godinho, A R, primary, Mielczarek, M, primary, Kubik, M, primary, Cho, J Y, primary, Tarando, F, primary, Lourenco Marmelo, B F, primary, Reis, L, primary, Domingues, K, primary, Krestjyaninov, MV, primary, Mesquita, J, primary, Ikonomidis, I, primary, Ferferieva, V, primary, King, GJ, primary, D'ascenzi, F, primary, Ferrera Duran, C, primary, Sormani, P, primary, Gonzalez Fernandez, O, primary, Tereshina, O, primary, Cambronero Cortinas, E, primary, Kupczynska, K, primary, Carvalho, J F, primary, Shivalkar, B, primary, Aghamohammadzadeh, R, primary, Cifra, B, primary, Kuznetsov, VA, primary, Van Zalen, JJ, primary, Kochanowski, J, primary, Goebel, B, primary, Ladeiras-Lopes, R, primary, Karvandi, M, primary, Alonso Salinas, G, primary, Unkun, T, primary, Ranjbar, S, primary, Hubert, A, primary, Enescu, OA, primary, Liccardo, M, primary, Cameli, M, primary, Ako, E, primary, Lembo, M, primary, Goffredo, C, primary, Enache, R, primary, Wdowiak-Okrojek, K, primary, Nemes, A, primary, Di Salvo, G, primary, Capotosto, L, primary, Caravaca, P, primary, Maceira Gonzalez, A M, primary, Iriart, X, primary, Jug, B, primary, Garcia Campos, A, additional, Capin Sampedro, E, additional, Corros Vicente, C, additional, Martin Fernandez, M, additional, Leon Arguero, V, additional, Fidalgo Arguelles, A, additional, Velasco Alonso, E, additional, Lopez Iglesias, F, additional, De La Hera Galarza, JM, additional, Chaparro-Munoz, M, additional, Recio-Mayoral, A, additional, Vlachopoulos, C, additional, Ioakeimidis, N, additional, Felekos, I, additional, Abdelrasoul, M, additional, Aznaouridis, K, additional, Chrysohoou, C, additional, Rousakis, G, additional, Aggeli, K, additional, Tousoulis, D, additional, Faustino, AC, additional, Paiva, L, additional, Fernandes, A, additional, Costa, M, additional, Cachulo, MC, additional, Goncalves, L, additional, Emma, F, additional, Rinelli, G, additional, Esposito, C, additional, Franceschini, A, additional, Doyon, A, additional, Raimondi, F, additional, Schaefer, F, additional, Pongiglione, G, additional, Mateucci, MC, additional, Vago, H, additional, Juhasz, C, additional, Janosa, C, additional, Oprea, V, additional, Balint, OH, additional, Temesvari, A, additional, Simor, T, additional, Kadar, K, additional, Merkely, B, additional, Bruno, R M, additional, Borghini, A, additional, Stea, F, additional, Gargani, L, additional, Mercuri, A, additional, Sicari, R, additional, Picano, E, additional, Lozano Granero, C, additional, Carbonell San Roman, A, additional, Moya Mur, JL, additional, Fernandez-Golfin, C, additional, Moreno Planas, J, additional, Fernandez Santos, S, additional, Casas Rojo, E, additional, Hernandez-Madrid, A, additional, Zamorano Gomez, JL, additional, Pearce, K, additional, Gamlin, W, additional, Miller, C, additional, Schmitt, M, additional, Seong, IW, additional, Kim, KH, additional, Kim, MJ, additional, Jung, HO, additional, Sohn, IS, additional, Park, SM, additional, Cho, GY, additional, Choi, JO, additional, Park, SW, additional, Nazir, SA, additional, Khan, JN, additional, Singh, A, additional, Kanagala, P, additional, Squire, I, additional, Mccann, GP, additional, Di Lisi, D, additional, Meschisi, MC, additional, Brunco, V, additional, Badalamenti, G, additional, Bronte, E, additional, Russo, A, additional, Novo, S, additional, Von Tscharner, M, additional, Urheim, S, additional, Aakhus, S, additional, Seiler, C, additional, Schmalholz, S, additional, Biering-Sorensen, T, additional, Cheng, S, additional, Oparil, S, additional, Izzo, J, additional, Pitt, B, additional, Solomon, SD, additional, Zaborska, B, additional, Jaxa-Chamiec, T, additional, Tysarowski, M, additional, Budaj, A, additional, Cordova, F, additional, Aguirre, O, additional, Sanabria, S, additional, Ortega, J, additional, Romeo, G, additional, Perazzolo Marra, M, additional, Tona, F, additional, Famoso, G, additional, Pigatto, E, additional, Cozzi, F, additional, Iliceto, S, additional, Badano, LP, additional, Kriatselis, C, additional, Gerds-Li, JH, additional, Kropf, M, additional, Pieske, B, additional, Graefe, M, additional, Martinez Santos, P, additional, Batlle Lopez, E, additional, Vilacosta, I, additional, Sanchez Sauce, B, additional, Espana Barrio, E, additional, Jimenez Valtierra, J, additional, Campuzano Ruiz, R, additional, Alonso Bello, J, additional, Martin Rios, MD, additional, Farrashi, M, additional, Abtahi, H, additional, Sadeghi, H, additional, Sadeghipour, P, additional, Tavoosi, A, additional, Abdel Rahman, TA, additional, Mohamed, LA, additional, Maghraby, HM, additional, Kora, IM, additional, Abdel Hameed, FR, additional, Ali, MN, additional, Al Shehri, A, additional, Youssef, A, additional, Gad, A, additional, Alsharqi, M, additional, Alsaikhan, L, additional, Andreini, D, additional, Rota, C, additional, Guglielmo, M, additional, Mushtaq, S, additional, Baggiano, A, additional, Beltrama, V, additional, Solbiati, A, additional, Guaricci, AI, additional, Pepi, M, additional, Trifunovic, D, additional, Sobic Saranovic, D, additional, Savic, L, additional, Grozdic Milojevic, I, additional, Asanin, M, additional, Srdic, M, additional, Petrovic, M, additional, Zlaic, N, additional, Mrdovic, I, additional, Dogan, C, additional, Izci, S, additional, Gecmen, C, additional, Unkun, T, additional, Cap, M, additional, Erdogan, E, additional, Onal, C, additional, Yilmaz, F, additional, Ozdemir, N, additional, Muser, D, additional, Tioni, C, additional, Zanuttini, D, additional, Morocutti, G, additional, Spedicato, L, additional, Bernardi, G, additional, Proclemer, A, additional, Pranevicius, R, additional, Zapustas, N, additional, Briedis, K, additional, Valuckiene, Z, additional, Jurkevicius, R, additional, Juffermans, LJM, additional, Enait, V, additional, Van Royen, N, additional, Van Rossum, AC, additional, Kamp, O, additional, Khalaf, HASSEN, additional, Hitham, SAKER, additional, Osama, AS, additional, Abazid, RAMI, additional, Guall, RAHIM, additional, Durdan, SHAFAT, additional, Mohammed, ZYAD, additional, Stella, S, additional, Rosa, I, additional, Ancona, F, additional, Spartera, M, additional, Italia, L, additional, Latib, A, additional, Colombo, A, additional, Margonato, A, additional, Agricola, E, additional, Scatena, C, additional, Mazzanti, C, additional, Conte, L, additional, Pugliese, N, additional, Barletta, V, additional, Bortolotti, U, additional, Naccarato, AG, additional, Di Bello, V, additional, Bala, G, additional, Roosens, B, additional, Hernot, S, additional, Remory, I, additional, Droogmans, S, additional, Cosyns, B, additional, Generati, G, additional, Labate, V, additional, Donghi, V, additional, Pellegrino, M, additional, Carbone, F, additional, Alfonzetti, E, additional, Guazzi, M, additional, Dabrowski, R, additional, Kowalik, I, additional, Firek, B, additional, Chwyczko, T, additional, Szwed, H, additional, Kawamura, A, additional, Kawano, S, additional, Zaroui, A, additional, Ben Said, R, additional, Ben Halima, M, additional, Kheder, N, additional, Farhati, A, additional, Mourali, S, additional, Mechmech, R, additional, Leite, L, additional, Martins, R, additional, Baptista, R, additional, Barbosa, A, additional, Ribeiro, N, additional, Oliveira, A, additional, Castro, G, additional, Pego, M, additional, Polte, C L, additional, Lagerstrand, K, additional, Johnsson, Å A, additional, Janulewicz, M, additional, Bech-Hanssen, O, additional, Gabriel, H, additional, Wisser, W, additional, Maurer, G, additional, Rosenhek, R, additional, El Aroussy, W, additional, Abdel Ghany, M, additional, Al Adeeb, K, additional, Ascione, L, additional, Carlomagno, G, additional, Sordelli, C, additional, Ferro, A, additional, Ascione, R, additional, Severino, S, additional, Caso, P, additional, Muraru, D, additional, Janei, C, additional, Haertel Miglioranza, M, additional, Cavalli, G, additional, Peluso, D, additional, Cucchini, U, additional, Badano, L, additional, Armario Bel, X, additional, Garcia-Garcia, C, additional, Ferrer Sistach, E, additional, Rueda Sobella, F, additional, Oliveras Vila, T, additional, Labata Salvador, C, additional, Serra Flores, J, additional, Lopez-Ayerbe, J, additional, Bayes-Genis, A, additional, Conte, E, additional, Gonella, A, additional, Morena, L, additional, Civelli, D, additional, Losardo, L, additional, Margaria, F, additional, Riva, L, additional, Tanga, M, additional, Carminati, C, additional, Muratori, M, additional, Gripari, P, additional, Ghulam Ali, S, additional, Fusini, L, additional, Vignati, C, additional, Bartorelli, AL, additional, Alamanni, F, additional, Marini, C, additional, Montorfano, M, additional, Ismaiel, A, additional, Ali, N, additional, Amry, S, additional, Serafin, A, additional, Kochanowski, J, additional, Filipiak, KJ, additional, Opolski, G, additional, Speranza, G, additional, Ando', G, additional, Magaudda, L, additional, Cramer, GE, additional, Bakker, J, additional, Michels, M, additional, Dieker, HJ, additional, Fouraux, MA, additional, Marcelis, CLM, additional, Timmermans, J, additional, Brouwer, MA, additional, Kofflard, MJM, additional, Vasconcelos, M, additional, Araujo, V, additional, Almeida, P, additional, Sousa, C, additional, Macedo, F, additional, Cardoso, JS, additional, Maciel, MJ, additional, Voilliot, D, additional, Huttin, O, additional, Venner, C, additional, Olivier, A, additional, Villemin, T, additional, Deballon, R, additional, Manenti, V, additional, Juilliere, Y, additional, Selton-Suty, C, additional, Dabrowska-Kugacka, A, additional, Dorniak, K, additional, Lewicka, E, additional, Szalewska, D, additional, Kutniewska-Kubik, M, additional, Raczak, G, additional, Kim, K H, additional, Yoon, H J, additional, Park, H J, additional, Ahn, Y, additional, Jeong, M H, additional, Cho, J G, additional, Park, J C, additional, Kim, J H, additional, Galli, E, additional, Habib, G, additional, Schnell, F, additional, Lederlin, M, additional, Daubert, JC, additional, Mabo, P, additional, Donal, E, additional, Faria, R, additional, Magalhaes, P, additional, Marques, N, additional, Domingues, K, additional, Lourenco, C, additional, Almeida, AR, additional, Teles, L, additional, Picarra, B, additional, Azevedo, O, additional, Oliveira, M, additional, Marmelo, B, additional, Almeida, A, additional, Bento, D, additional, Cruz, I, additional, Reis, L, additional, Gimaev, RH, additional, Melnikova, MA, additional, Olezov, NV, additional, Ruzov, VI, additional, Goncalves, P, additional, Almeida, M S, additional, Branco, P, additional, Carvalho, M S, additional, Dores, H, additional, Gaspar, M A, additional, Sousa, H, additional, Andrade, M J, additional, Mendes, M, additional, Makavos, G, additional, Varoudi, M, additional, Papadavid, E, additional, Andreadou, I, additional, Gravanis, K, additional, Liarakos, N, additional, Pavlidis, G, additional, Rigopoulos, D, additional, Lekakis, J, additional, Deluyker, D, additional, Bito, V, additional, Punzi, L, additional, Neilan, T, additional, Coen, K, additional, Gannon, S, additional, Bennet, K, additional, Clarke, JG, additional, Solari, M, additional, Cameli, M, additional, Focardi, M, additional, Corrado, D, additional, Bonifazi, M, additional, Henein, M, additional, Mondillo, S, additional, Gomez-Escalonilla, C, additional, De Agustin, A, additional, Egido, J, additional, Islas, F, additional, Simal, P, additional, Gomez De Diego, JJ, additional, Luaces, M, additional, Macaya, C, additional, Perez De Isla, L, additional, Zancanella, M, additional, Rusconi, C, additional, Musca, F, additional, Santambrogio, G, additional, De Chiara, B, additional, Vallerio, P, additional, Cairoli, R, additional, Giannattasio, G, additional, Moreo, A, additional, Alvarez Ortega, C, additional, Mori Junco, R, additional, Caro Codon, J, additional, Meras Colunga, P, additional, Ponz De Antonio, I, additional, Lopez Fernandez, T, additional, Valbuena Lopez, S, additional, Moreno Yanguela, M, additional, Lopez-Sendon, JL, additional, Surkova, E, additional, Bonanad-Lozano, C, additional, Lopez-Lereu, MP, additional, Monmeneu-Menadas, JV, additional, Gavara, J, additional, De Dios, E, additional, Paya-Chaume, A, additional, Escribano-Alarcon, D, additional, Chorro-Gasco, FJ, additional, Bodi-Peris, V, additional, Michalski, BW, additional, Miskowiec, D, additional, Kasprzak, JD, additional, Lipiec, P, additional, Morgado, G, additional, Caldeira, D, additional, Joao, I, additional, Almeida, A R, additional, Lopes, L, additional, Fazendas, P, additional, Cotrim, C, additional, Pereira, H, additional, De Block, C, additional, Buys, D, additional, Salgado, R, additional, Vrints, C, additional, Van Gaal, L, additional, Mctear, C, additional, Irwin, RB, additional, Dragulescu, A, additional, Friedberg, M, additional, Mertens, L, additional, Krinochkin, DV, additional, Yaroslavskaya, EI, additional, Zaharova, EH, additional, Pushkarev, GS, additional, Sugihara, C, additional, Patel, NR, additional, Sulke, AN, additional, Lloyd, GW, additional, Piatkowski, R, additional, Scislo, P, additional, Grabowski, M, additional, Marchel, M, additional, Roland, H, additional, Hamadanchi, A, additional, Otto, S, additional, Jung, C, additional, Lauten, A, additional, Figulla, HC, additional, Poerner, TC, additional, Sampaio, F, additional, Fonseca, P, additional, Fontes-Carvalho, R, additional, Pinho, M, additional, Campos, AS, additional, Castro, P, additional, Fonseca, C, additional, Ribeiro, J, additional, Gama, V, additional, Heck, R, additional, Hamdanchi, A, additional, Figulla, HR, additional, Ranjbar, S, additional, Ghaffaripour Jahromi, M, additional, Hinojar, R, additional, Fernandez Golfin, C, additional, Esteban, A, additional, Pascual-Izco, M, additional, Garcia-Martin, A, additional, Jimenez-Nacher, JJ, additional, Zamorano, JL, additional, Acar, R, additional, Bakal, RB, additional, Kaymaz, C, additional, Karvandi, M, additional, Galand, V, additional, Matelot, D, additional, Leclercq, C, additional, Carre, F, additional, Suran, BC, additional, Margulescu, AD, additional, Rimbas, RC, additional, Siliste, C, additional, Vinereanu, D, additional, Nocerino, P, additional, Urso, AC, additional, Borrino, A, additional, Carbone, C, additional, Follero, P, additional, Ciardiello, C, additional, Prato, L, additional, Salzano, G, additional, Marino, F, additional, Ruspetti, A, additional, Sparla, S, additional, Di Tommaso, C, additional, Loiacono, F, additional, D'ascenzi, F, additional, Porter, J, additional, Walker, M, additional, Lo Iudice, F, additional, Esposito, R, additional, Santoro, C, additional, Cocozza, S, additional, Izzo, R, additional, De Luca, N, additional, De Simone, G, additional, Trimarco, B, additional, Galderisi, M, additional, Gervasi, F, additional, Patti, G, additional, Mega, S, additional, Bono, M, additional, Di Sciascio, G, additional, Buture, A, additional, Badea, R, additional, Platon, P, additional, Ghiorghiu, I, additional, Jurcut, R, additional, Coman, IM, additional, Popescu, BA, additional, Ginghina, C, additional, Lunetta, M, additional, Spoto, MS, additional, Lo Vi, AM, additional, Pensabene, G, additional, Carita, P, additional, Coppola, G, additional, Assennato, P, additional, Shim, A, additional, Wejner-Mik, P, additional, Havasi, K, additional, Domsik, P, additional, Kalapos, A, additional, Forster, T, additional, Piros, GA, additional, Lengyel, C, additional, Orosz, A, additional, Bulbul, Z, additional, Issa, Z, additional, Al Sehly, A, additional, Pergola, V, additional, Oufi, S, additional, Conde, Y, additional, Cimino, E, additional, Rinaldi, E, additional, Ashurov, R, additional, Ricci, S, additional, Pergolini, M, additional, Vitarelli, A, additional, Lujan Valencia, JE, additional, Chaparro, M, additional, Garcia-Guerrero, A, additional, Cristo Ropero, MJ, additional, Izquierdo Bajo, A, additional, Madrona, L, additional, Monmeneu, JV, additional, Igual, B, additional, Lopez Lereu, P, additional, Garcia, MP, additional, Selmi, W, additional, Jalal, Z, additional, Thambo, JB, additional, Kosuta, D, additional, and Fras, Z, additional
Published: 2015
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6. Echocardiographic integrated backscatter for the differentiation between aortic valve calcification and valvular myxoid degeneration in rats

Author: Gillis, K., primary, Bala, G., additional, Roosens, B., additional, Remory, I., additional, De Raeve, H., additional, Tierens, S., additional, Hernot, S., additional, Van Camp, G., additional, Droogmans, S., additional, and Cosyns, B., additional
Published: 2014
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7. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area

Author: Montoro Lopez, M., primary, Iniesta Manjavacas, A., additional, Mori Junco, R., additional, Pena Conde, L., additional, Pons De Antonio, I., additional, Garcia Blas, S., additional, Lopez Fernandez, T., additional, Moreno Gomez, R., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Carro, A., additional, Kiotsekoglou, A., additional, Andoh, J., additional, Brown, S., additional, Kaski, J., additional, Imamura, Y., additional, Arai, K., additional, Uematsu, S., additional, Fukushima, K., additional, Hoshi, H., additional, Ashihara, K., additional, Takagi, A., additional, Hagiwara, N., additional, Gillis, K., additional, Bala, G., additional, Roosens, B., additional, Remory, I., additional, Droogmans, S., additional, Van Camp, G., additional, Cosyns, B., additional, Van De Heyning, C., additional, Magne, J., additional, Pierard, L., additional, Bruyere, P., additional, Davin, L., additional, De Maeyer, C., additional, Paelinck, B., additional, Vrints, C., additional, Lancellotti, P., additional, Borowiec, A., additional, Dabrowski, R., additional, Kowalik, I., additional, Firek, B., additional, Chwyczko, T., additional, Janas, J., additional, Szwed, H., additional, Tufaro, V., additional, Fragasso, G., additional, Ingallina, G., additional, Marini, C., additional, Fisicaro, A., additional, Loiacono, F., additional, Margonato, A., additional, Agricola, E., additional, Ferreira, F., additional, Pereira, T., additional, Abreu, J., additional, Labandeiro, J., additional, Fiarresga, A., additional, Ferreira, A., additional, Galrinho, A., additional, Branco, L., additional, Timoteo, A., additional, Ferreira, R., additional, Marmol, R., additional, Gomez, M., additional, Garcia, K., additional, Sanmiguel, D., additional, Cabades, C., additional, Monteagudo, M., additional, Nunez, C., additional, Fernandez, C., additional, Diez, J., additional, Roldan, I., additional, Kolesnyk, M., additional, Ancona, M., additional, Oppizzi, M., additional, Krestjyaninov, M., additional, Razin, V., additional, Gimaev, R., additional, Carminati, M., additional, Piazzese, C., additional, Tsang, W., additional, Lang, R., additional, Caiani, E., additional, Goncalves, S., additional, Ramalho, A., additional, Placido, R., additional, Marta, L., additional, Cortez Dias, N., additional, Magalhaes, A., additional, Menezes, M., additional, Martins, S., additional, Almeida, A., additional, Nunes Diogo, A., additional, Stokke, T. M., additional, Ruddox, V., additional, Sarvari, S. I., additional, Otterstad, J. E., additional, Aune, E., additional, Edvardsen, T., additional, Pirone, D., additional, De Francesco, V., additional, Marino, F., additional, Gervasi, F., additional, Demartini, C., additional, Goffredo, C., additional, Bono, M., additional, Mega, S., additional, Chello, M., additional, Di Sciascio, G., additional, Martin Hidalgo, M., additional, Seoane Garcia, T., additional, Carrasco Avalos, F., additional, Mesa Rubio, M., additional, Delgado Ortega, M., additional, Ruiz Ortiz, M., additional, Mazuelos Bellido, F., additional, Suarez De Lezo Herrero De Tejada, J., additional, Pan Alvarez De Osorio, M., additional, Suarez De Lezo Cruz Conde, J., additional, Lopez Granados, A., additional, Romero Moreno, M., additional, Pan Alvarez-Ossorio, M., additional, Menichetti, F., additional, Bongiorni, M., additional, Ferro, B., additional, Segreti, L., additional, Bertini, P., additional, Mariotti, R., additional, Baldassarri, R., additional, Di Cori, A., additional, Zucchelli, G., additional, Guarracino, F., additional, Santoro, A., additional, Federco Alvino, F., additional, Giovanni Antonelli, G., additional, Raffaella De Vito, R., additional, Roberta Molle, R., additional, Sergio Mondillo, S., additional, Mahmoud, Y., additional, Abdel-Kader, M., additional, Guindy, R., additional, Elzahwy, S., additional, Dijkema, E., additional, Molenschot, M., additional, Slieker, M., additional, Oliveira Da Silva, C., additional, Sahlen, A., additional, Winter, R., additional, Back, M., additional, Ruck, A., additional, Settergren, M., additional, Manouras, A., additional, Shahgaldi, K., additional, and Ruzov, V., additional
Published: 2013
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8. Assessment of intraoperative microaspiration: does a modified cuff shape improve sealing?

Author: D'HAESE, J., primary, DE KEUKELEIRE, T., additional, REMORY, I., additional, VAN ROMPAEY, K., additional, UMBRAIN, V., additional, and POELAERT, J., additional
Published: 2013
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9. Poster session 6

Author: Lofmark, H, Winter, R, Moukarzel, JA, Filipuzzi, JM, Vaisbuj, F, Salmo, F, Guevara, E, Barbier, P, Savioli, G, Keramida, K, Kouris, N, Dawson, D, Olympios, CD, Nihoyannopoulos, P, Meel, R, Peters, F, Libhaber, E, Nel, S, Goncalves, R, Essop, MR, Dinis, P G, Teixeira, R, Madeira, M, Cachulo, MC, Goncalves, L, Jorstig, S, Emilsson, K, Waldenborg, M, Liden, M, Wodecki, M, Thunberg, P, Perez, Valverde, Sotelo, J, Beerbaum, P, Grotenhuis, H, Greil, G, Razavi, R, Uribe, S, Figueroa, A, Zemedkun, M, Wang, Z, Asch, FM, Gizzi, G, Fabiani, D, Lavorgna, A, Napoletano, C, Saha, S K, Muthukumar, L, Englund, E, Toole, R, Gopal, AS, Di Salvo, G, Issa, Z, Moiduddin, N, Siblini, G, Bulbul, Z, Yurdakul, SELEN, Ercan, G, Tekkesin, ILKER, Sahin, ST, Cengiz, B, Celik, G, Demircan, SABRI, Aytekin, SAIDE, Chumarnaya, T, Alueva, Y, Kochmasheva, VV, Solovyova, O, Tuset, L, Maceira Gonzalez, A M, Igual, B, Bruin De- Bon, HACM, Cocchieri, R, Wagner, GS, Eberl, S, Brink Van Den, RBA, Bouma, BJ, Onishi, T, Kawai, H, Tanaka, H, Fujiwara, S, Hirata, K, Marketou, M, Parthenakis, F, Kontaraki, J, Patrianakos, A, Nakou, H, Maragkoudakis, S, Vougia, D, Logakis, J, Roufas, K, Vardas, P, Bayuga, MT, Ramboyong, RE, Johansson, M C, Wallentin Guron, C, Thurin, A, Wessling, N, Almodares, Q, Fu, M, Mandour Ali, M, Mohamed, LA, Abd Al-Rahman, T, Maghraby, HM, Kora, IM, Abdel-Hameed, FR, Ali, MN, King, GJ, Byrne, D, Bennett, K, Norris, K, Daly, C, Murphy, RT, Marti, G, Degiovanni, A, Di Ruocco, MV, Sartori, C, Devecchi, P, Marino, P, Angelis, A, Aggeli, K, Ioakeimidis, N, Felekos, I, Aznaouridis, K, Rokas, K, Abdelrasoul, M, Terentes, D, Vlachopoulos, C, Tousoulis, D, Spinelli, L, Stabile, E, Santoro, M, Morisco, C, Giudice, C A, Esposito, G, Trimarco, B, Dragoi Galrinho, R, Ciobanu, AO, Rimbas, RC, Manole, GC, Marinescu, B, Vinereanu, D, Krljanac, G, Trifunovic, D, Savic, L, Asanin, M, Lasica, R, Aleksandric, S, Zlatic, N, Petrovic, M, Jovanovic, LJ, Mrdovic, I, Zahidova, K, aethiology, Chronic heart failure of ishemic, anemia, Trifunovic, D, Krljanac, G, Sobic Saranovic, D, Asanin, M, Grozdic Milojevic, I, Savic, L, Vasiljevic, Z, Aleksandric, S, Srdic, M, Mrdovic, I, Mateescu, AD, Calin, A, Rosca, M, Beladan, CC, Enache, R, Gurzun, MM, Varga, P, Calin, C, Ginghina, C, Popescu, BA, Melissopoulou, M, Nguyen, V, Mathieu, T, Attias, D, Dreyfus, J, Codogno, I, Vahanian, A, Messika-Zeitoun, D, study, The COFRASA/GENERAC, Stefanidis, A, Komatanou, E, Anagnostou, E, Armatas, G, Samiotou, D, Papaspyropoulos, A, Philippou, P, Korlou, P, Tzerefos, S, Kranidis, A, Kammerer, I, Wiedemann, M, Sack, FU, Koyama, T, Fukuhara, K, Imai, K, Yamada, R, Kume, T, Neishi, Y, Uemura, S, Pergola, V, Di Salvo, G, Fadel, B, Aladmawi, M, Shahid, M, Alamri, M, Bulbul, Z, Issa, Z, Alhalees, Z, Rafael De La Espriella Juan, RDLE, Rafael Paya-Serrano, RPS, Jose-Leando Perez-Bosca, JLPB, Francisco Ridocci-Soriano, FRS, Oscar Fabregat-Andres, OFA, Cristina Albiach-Montanana, CAM, Natalia Chacon-Hernandez, NCH, Laura Higueras-Ortega, LHO, Blanca Trejo-Velasco, BTV, Salvador Morell-Cabedo, SMC, Bech-Hanssen, O, Polte, CL, Johnsson, AA, Cederbom, U, Lagerstrand, K, Gao, SA, Cho, E J, Hwang, J W, Park, S J, Yun, H R, Lee, S C, Park, S W, Poilane, M, Cueff, C, Jaafar, P, Jobbe Duval, A, Guijarro, D, Le Tourneau, T, Vaturi, M, Kotler, T, Shapira, Y, Weisenberg, D, Monakier, D, Kazum, S, Sagie, A, Valuckiene, Z, Ovsianas, J, Jurgaityte, J, Jasiskyte, V, Jurkevicius, R, Jenei, C, Muraru, D, Aruta, P, Miglioranza, M H, Cavalli, G, Romeo, G, Peluso, D, Cucchini, U, Iliceto, S, Badano, L P, Yesin, M, Kalcik, M, Gursoy, MO, Gunduz, S, Astarcioglu, MA, Karakoyun, S, Bayam, E, Cersit, S, Ozkan, M, Galuszka, O M, Reinthaler, M, Rutschow, S, Gross, M, Landmesser, U, Kasner, M, Caggegi, A M, Scandura, S, Capranzano, P, Mangiafico, S, Ronsivalle, G, Cannata, S, Farruggio, S, Giaquinta, S, Grasso, C, Tamburino, C, Merchan Cuenda, M, Fuentes Canamero, M E, Bengla Limpo, B, Chacon Pinero, A, Millan Nunez, M V, Nogales Asensio, JM, Lopez Minguez, J R, Garcia Corrales, C, Aranda Lopez, C, Merchan Herrera, A, Merchan Cuenda, M, Fuentes Canamero, M E, Bengla Limpo, B, Millan Nunez, M V, Nogales Asensio, J M, Lopez Minguez, J R, Chacon Pinero, A, Marquez Lozano, P, Garcia Corrales, C, Merchan Herrera, A, Lo Presti, M, Polizzi, V, Pino, GP, Luzi, G, Fiorilli, R, Pergolini, A, Madeo, A, Malouf, J, Buffa, V, Musumeci, F, Islas, F, Almeria, C, Olmos, C, Garcia, E, Nombela, L, De Agustin, JA, Marcos-Alberca, P, Mahia, P, Macaya, C, Perez De Isla, L, Pontes Dos Santos, R A, Correia, E, Cruz, I, Reis, L, Oliveira, M, Faria, R, Magalhaes, P, Domingues, K, Picarra, B, Marques, N, Nemes, A, Domsik, P, Kalapos, A, Sepp, R, Foldeak, D, Borbenyi, Z, Forster, T, Masiha, S, Reis, L, Teixeira, R, Caetano, F, Almeida, I, Trigo, J, Botelho, A, Silva, J, Nascimento, J, Goncalves, L, Cubero Gallego, H, Dobarro Perez, D, Diez De Las Heras, D, Llerena Butron, S, Tobar Ruiz, J, Martin Morquecho, I, Arnold, R, San Roman Calvar, JA, De Gregorio, C, Ando', G, Dattilo, G, Trio, O, Cusma' Piccione, M, Zito, C, Nicotera, A, D'angelo, M, Carerj, S, Ziolkowska, L, Spiewak, M, Malek, L, Boruc, A, Kawalec, W, Alvarez-Ortega, C A, Gonzalez Fernandez, O, Refoyo Salicio, E, Mori, R, Peinado Peinado, R, Lago, M, Trigo, E, Lopez-Sedon, JL, Yuan, L, Zhang, XX, Xie, MX, Jin, XY, Hospital, Union, College, Tongji Medical, Science, Huazhong University of, Technology, Ultrasonography, Department of, Leao, S, Bento, D, Lourenco, C, Domingues, K, Almeida, AR, Marmelo, B, Picarra, B, Lima, R, Faria, R, Azevedo, O, Accadia, M, Irace, L, Abitabile, M, Iengo, R, Arnese, MR, Cocchia, R, Scotto Di Uccio, F, Spadaro, P, Tuccillo, A, Tuccillo, B, Budnik, M, Piatkowski, R, Kochanowski, J, Gaska, M, Glowacka, P, Karolczak, P, Ochijewicz, D, Opolski, G, Stevanovic, A, Dekleva, M, Tsai, W-C, Yang, L-T, Liu, Y-W, Abusalma, Y, O'connell, E, Kenny, C, Mcdonald, K, Mohamed Fereig Hamed, H, Hafez, EMAN, Habib, SHIMAA, Peluso, D, Pigatto, E, Romeo, G, Cucchini, U, Muraru, D, Aruta, P, Cozzi, F, Punzi, L, Iliceto, S, Badano, LP, Podoleanu, C, Coman, I, Jeremias, ZS, Varga, A, Tarta, C, Grancea, I, Tarusi, M, Frigy, A, Carasca, E, Doronzo, A, Piazza, R, Neglia, L, Cervesato, E, Nicolosi, GL, Cassin, M, Upton, R, Aye, C, Davis, E, Packham, A, Arnold, L, Kenworthy, Y, Lamata, P, Lewandowski, A, Leeson, P, Abuladze, GA, Jinjolia, NJ, Ribeiro, JM, Teixeira, R, Fernandes, A, Cassandra, M, Pinto, H, Marques, MG, Raposo, H, Carreira, A, Campos, M, Goncalves, L, De La Chica, JA, Ortiz Garrido, A, Cuenca, V, Conejo, L, Zabala, I, De Mora, M, Petruzzelli, MF, Vasti, MP, Scali, MC, Tramacere, F, D'errico, MP, Gianicolo, EAL, Andreassi, MG, Picano, E, Portaluri, M, Ferrera Duran, C, Gomez-Escalonilla, C, De Agustin, JA, Egido, J, Almeria, C, Simal, P, Marcos, P, Rodrigo, JL, Macaya, C, Perez De Isla, L, Tomaszewski, M, Brzozowski, W, Tomaszewski, A, Poterala, M, Diaz-Pelaez, E, Marciniak, A, Gargallo-Fernandez, P, Barrio-Rodriguez, A, Araco, M, Sharma, R, Wierzbowska-Drabik, K, Kasprzak, JD, Wierzbowska-Drabik, K, Kasprzak, JD, Velasco Del Castillo, S, Anton Ladislao, A, Cacicedo Fernandez Bobadilla, A, Onandia Gandarias, JJ, Sainz, S, Gomez Sanchez, V, Rodriguez Sanchez, I, Garcia Cuenca, E, Zugazabeitia Irazabal, G, Generati, G, Bandera, F, Pellegrino, M, Carbone, F, Labate, V, Alfonzetti, E, Villani, S, Gaeta, M, Ferraro, O, Guazzi, M, Zaborska, B, Smarz, K, Pilichowska-Paszkiet, E, Sikora-Frac, M, Budaj, A, De Diego Soler, O, Ferrer Sistach, E, Vallejo Camazon, N, Lopez-Ayerbe, J, Teis Soley, A, Gual Capllonch, F, Serrano Garcia, S, Bernal Labrador, E, Junca Puig, G, Bayes-Genis, A, Merchan-Gomez, S, Garcia-Sanchez, MJ, Barreiro-Perez, MJ, Arribas-Jimenez, A, Sanchez-Corral, E, Cruz-Gonzalez, I, Martin-Leal, LI, Gajate-Herrero, D, Perdiguero-Martin, PL, Sanchez-Fernandez, PL, Lee, M, Jang, YJ, Lee, YJ, Kim, YS, Chun, WJ, Kang, GH, Oh, JH, Aquila, I, Hinojar, R, Fernandez-Golfin, C, Gonzalez, A, Rincon, LM, Casas, E, Ruiz, S, Barrios, V, Jimenez-Nacher, JJ, Zamorano, JL, Necas, J, Kovalova, S, Perea, GO, Lombardero, M, Henquin, R, Tinetti, M, Corneli, M, Sotaquira, Miguel, Cairati, Mattia, Ettorre, Alessandro, Pepi, Mauro, Tamborini, Gloria, Caiani, Enrico, Sanchez-Martinez, S, Duchateau, N, Erdei, T, Fraser, A, Piella, G, Bijnens, B H, Nestaas, E, Stoylen, A, Fugelseth, D, Hinojar, R, Fernandez-Golfin, C, Esteban, A, Gonzalez-Gomez, A, Garcia-Martin, A, Casas Rojo, E, Pascual-Izco, M, Jimenez-Nacher, JJ, Zamorano, JL, Cerne, A, Berden, P, Agelaki, M, Sundar, S, Antonakaki, D, Grapsa, J, Dawson, D, Papadopoulos, C, Katsivas, A, Nihoyannopoulos, P, Sanchis Ruiz, L, Sanz, M, Bijnens, B, Giraldeau, G, Grazioli, G, Marin, M, Montserrat, S, Sitges, M, Cambronero Cortinas, E, Grapsa, J, Dawson, D, Howard, L, Gin-Sing, W, Valle, A, Corbi-Pascual, MJ, Saez-Mendez, L, Gibbs, S, Nihoyannopoulos, P, Grue, J F, Storve, S, Mjoelstad, O C, Samstad, S O, Dalen, H, Torp, H, Haugen, B O, Yim, D, Mertens, L, Friedberg, MK, Grosse-Wortmann, L, Dragulescu, A, Djikic, DDJ, Simic, SD, Peric, VP, Mujovic, NM, Jankovic, NJ, Marinkovic, MM, Martinez Santos, P, Batlle Lopez, E, Vilacosta, I, Sanchez Sauce, B, De La Rosa Riestra, A, Alonso Bello, J, Espana Barrio, E, Jimenez Valtierra, J, Campuzano Ruiz, R, Rios, Martin, Vrsalovic, M, Hummel, SL, Ghanbari, H, Alpert, C, Oral, H, Kolias, TJ, Mghaieth Zghal, F, Jabberi, Z, Rekik, B, Boudiche, S, Aloui, H, Ben Hlima, M, Ouali, S, Larbi, N, Mourali, MS, Nemes, A, Marton, I, Domsik, P, Kalapos, A, Posfai, E, Modok, S, Borbenyi, Z, Forster, T, Maceira Gonzalez, A M, Monmeneu, JV, Igual, B, Lopez Lereu, MP, Garcia, P, Cosin Sales, J, Maceira Gonzalez, A M, Igual, B, Monmeneu, JV, Lopez Lereu, P, Garcia, MP, Cosin Sales, J, Bala, G, Baudhuin, H, Gillis, K, Remory, I, Krasniqi, A, Lahoutte, T, Devoogdt, N, Droogmans, S, Cosyns, B, Hernot, S, Bulugahapitiya, D S, Bebb, O, Moustafa, A, Vilades, D, Colom Comi, C, Perez-Perez, A, Carreras, F, Leta, R, Pons, G, Jinjolia, NJ, and Abuladze, GA
Abstract: Purpose: To explore the cost effectiveness of expert hand-held echo (HHE) upstream as an alternative to referral for a complete transthoracic echo (TTE) in clinical routine. We hypothized that an upstream HHE approach would prove adequate and cost effective in terms of - Decrease the numbers of required TTE - Fewer revisits to the outpatient unit - Shorten the length of admission - Increase the number of higly specialized echoes, i.e. stress echo, transesophageal echoes - Shorten the time to final diagnosis and decrease the concerns for the patient who is forced to wait for survey and results at complete TTE. Methods: In this study, a HHE scanner (V-scan, GE Health care) was kept available for the senior consultants with level 3 TTE certification, for use in patients where a TTE was indicated. HHE was performed in different clinical scenarios such in the emergency room, during consultation of inpatients or in the clinic of outpatients. The results of HHE was documented in the patient record under a heading and can directly be found upon request. The length of hospital stay during a representative week, is compared between patients who have not undergone HHE with patients undergoing HHE. Results: Out of a total of 94 patients examined with HHE, 71 patients were not in need of a complete TTE. Additional 11 patients received a more rapid investigation i.e stress-echo, transesophageal echocardiography or other investigations that would otherwise have been delayed because of waiting for the complete TTE. 12 patients were in need of a complete TTE for a more precise analysis. In the heart clinic of Danderyds hospital approximately 18 inpatients were examined with a complete TTE every ordinary week and that postpone the day of submission from hospital among approximately 6 patients a week. Every day of care in hospital cost 445 € in an ordinary ward and 981 € in the heart intensive care unit. This means there is a cost benefit of approximately 3741 € every week if it is possible to prevent this postponing of submission. Conclusions: Upstream HHE in clinical routine was in the setting of this study highly cost-effective, decreasing the need of TTE to a great extent, and leading to quicker diagnosis, shorter hospital stays and less anxiety in patients during the waiting time for a complete TTE and before a response is received.
Published: 2015
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10. Poster session 5

Author: Colunga Blanco, S, Garcia Campos, A, Capin Sampedro, E, Corros Vicente, C, Martin Fernandez, M, Leon Arguero, V, Fidalgo Arguelles, A, Velasco Alonso, E, Lopez Iglesias, F, De La Hera Galarza, JM, Gonzalez Matos, C, Chaparro-Munoz, M, Recio-Mayoral, A, Angelis, A, Vlachopoulos, C, Ioakeimidis, N, Felekos, I, Abdelrasoul, M, Aznaouridis, K, Chrysohoou, C, Rousakis, G, Aggeli, K, Tousoulis, D, Dinis, P G, Faustino, AC, Paiva, L, Fernandes, A, Costa, M, Cachulo, MC, Goncalves, L, Chinali, M, Emma, F, Rinelli, G, Esposito, C, Franceschini, A, Doyon, A, Raimondi, F, Schaefer, F, Pongiglione, G, Mateucci, MC, Toth, A, Vago, H, Juhasz, C, Janosa, C, Oprea, V, Balint, OH, Temesvari, A, Simor, T, Kadar, K, Merkely, B, Andreassi, M G, Bruno, R M, Borghini, A, Stea, F, Gargani, L, Mercuri, A, Sicari, R, Picano, E, Rodriguez Munoz, D, Lozano Granero, C, Carbonell San Roman, A, Moya Mur, JL, Fernandez-Golfin, C, Moreno Planas, J, Fernandez Santos, S, Casas Rojo, E, Hernandez-Madrid, A, Zamorano Gomez, JL, Reid, A B, Pearce, K, Gamlin, W, Miller, C, Schmitt, M, Park, JH, Seong, IW, Kim, KH, Kim, MJ, Jung, HO, Sohn, IS, Park, SM, Cho, GY, Choi, JO, Park, SW, study, NORMAL, Shetye, A, Nazir, SA, Khan, JN, Singh, A, Kanagala, P, Squire, I, Mccann, GP, Novo, G, Di Lisi, D, Meschisi, MC, Brunco, V, Badalamenti, G, Bronte, E, Russo, A, Novo, S, De Marchi, S F, Von Tscharner, M, Urheim, S, Aakhus, S, Seiler, C, Schmalholz, S, Cikes, M, Biering-Sorensen, T, Cheng, S, Oparil, S, Izzo, J, Pitt, B, Solomon, SD, Smarz, K, Zaborska, B, Jaxa-Chamiec, T, Tysarowski, M, Budaj, A, Illatopa, V, Cordova, F, Aguirre, O, Sanabria, S, Ortega, J, Peluso, D, Romeo, G, Perazzolo Marra, M, Tona, F, Famoso, G, Pigatto, E, Cozzi, F, Iliceto, S, Badano, LP, Wellnhofer, E, Kriatselis, C, Gerds-Li, JH, Kropf, M, Pieske, B, Graefe, M, De La Rosa Riestra, A, Martinez Santos, P, Batlle Lopez, E, Vilacosta, I, Sanchez Sauce, B, Espana Barrio, E, Jimenez Valtierra, J, Campuzano Ruiz, R, Alonso Bello, J, Martin Rios, MD, Sattarzadeh Badkoubeh, R, Farrashi, M, Abtahi, H, Sadeghi, H, Sadeghipour, P, Tavoosi, A, Mandour Ali, M, Abdel Rahman, TA, Mohamed, LA, Maghraby, HM, Kora, IM, Abdel Hameed, FR, Ali, MN, Azoz, A, Al Shehri, A, Youssef, A, Gad, A, Alsharqi, M, Alsaikhan, L, Pontone, G, Andreini, D, Rota, C, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Solbiati, A, Guaricci, AI, Pepi, M, Krljanac, G, Trifunovic, D, Sobic Saranovic, D, Savic, L, Grozdic Milojevic, I, Asanin, M, Srdic, M, Petrovic, M, Zlaic, N, Mrdovic, I, Acar, R, Dogan, C, Izci, S, Gecmen, C, Unkun, T, Cap, M, Erdogan, E, Onal, C, Yilmaz, F, Ozdemir, N, Nucifora, G, Muser, D, Tioni, C, Zanuttini, D, Morocutti, G, Spedicato, L, Bernardi, G, Proclemer, A, Sirtautas, A, Pranevicius, R, Zapustas, N, Briedis, K, Valuckiene, Z, Jurkevicius, R, Roos, S T, Juffermans, LJM, Enait, V, Van Royen, N, Van Rossum, AC, Kamp, O, Qasem, M S, Khalaf, HASSEN, Hitham, SAKER, Osama, AS, Abazid, RAMI, Guall, RAHIM, Durdan, SHAFAT, Mohammed, ZYAD, Marini, C, Stella, S, Rosa, I, Ancona, F, Spartera, M, Italia, L, Latib, A, Colombo, A, Margonato, A, Agricola, E, Fabiani, I, Scatena, C, Mazzanti, C, Conte, L, Pugliese, N, Barletta, V, Bortolotti, U, Naccarato, AG, Di Bello, V, Gillis, K, Bala, G, Roosens, B, Hernot, S, Remory, I, Droogmans, S, Cosyns, B, Bandera, F, Generati, G, Labate, V, Donghi, V, Pellegrino, M, Carbone, F, Alfonzetti, E, Guazzi, M, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Szwed, H, Lim, YJ, Kawamura, A, Kawano, S, Chalbia, T E, Zaroui, A, Ben Said, R, Ben Halima, M, Kheder, N, Farhati, A, Mourali, S, Mechmech, R, Santos, M, Leite, L, Martins, R, Baptista, R, Barbosa, A, Ribeiro, N, Oliveira, A, Castro, G, Pego, M, Gao, S A, Polte, C L, Lagerstrand, K, Johnsson, A A, Janulewicz, M, Bech-Hanssen, O, Zilberszac, R, Gabriel, H, Wisser, W, Maurer, G, Rosenhek, R, Farrag, AAM, El Aroussy, W, Abdel Ghany, M, Al Adeeb, K, Palmiero, G, Ascione, L, Carlomagno, G, Sordelli, C, Ferro, A, Ascione, R, Severino, S, Caso, P, Aruta, P, Muraru, D, Janei, C, Haertel Miglioranza, M, Cavalli, G, Romeo, G, Peluso, D, Cucchini, U, Iliceto, S, Badano, L, De Diego Soler, O, Armario Bel, X, Garcia-Garcia, C, Ferrer Sistach, E, Rueda Sobella, F, Oliveras Vila, T, Labata Salvador, C, Serra Flores, J, Lopez-Ayerbe, J, Bayes-Genis, A, Fasano, D, Conte, E, Gonella, A, Morena, L, Civelli, D, Losardo, L, Margaria, F, Riva, L, Tanga, M, Tamborini, G, Carminati, C, Muratori, M, Gripari, P, Ghulam Ali, S, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Pepi, M, Ancona, F, Rosa, I, Stella, S, Marini, C, Spartera, M, Latib, A, Montorfano, M, Colombo, A, Margonato, A, Agricola, E, Raafat, D M, Ismaiel, A, Ali, N, Amry, S, Medicine, Faculty of, University, Assiut, Assiut, Egypt, Department, Pediatric, Marchel, M, Serafin, A, Kochanowski, J, Filipiak, KJ, Opolski, G, De Gregorio, C, Speranza, G, Ando', G, Magaudda, L, Gommans, D H F, Cramer, GE, Bakker, J, Michels, M, Dieker, HJ, Fouraux, MA, Marcelis, CLM, Timmermans, J, Brouwer, MA, Kofflard, MJM, Godinho, A R, Vasconcelos, M, Araujo, V, Almeida, P, Sousa, C, Macedo, F, Cardoso, JS, Maciel, MJ, Mielczarek, M, Voilliot, D, Huttin, O, Venner, C, Olivier, A, Villemin, T, Deballon, R, Manenti, V, Juilliere, Y, Selton-Suty, C, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Carbone, F, Alfonzetti, E, Guazzi, M, Kubik, M, Dabrowska-Kugacka, A, Dorniak, K, Lewicka, E, Szalewska, D, Kutniewska-Kubik, M, Raczak, G, Cho, J Y, Kim, K H, Yoon, H J, Park, H J, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Kim, J H, Tarando, F, Galli, E, Habib, G, Schnell, F, Lederlin, M, Daubert, JC, Mabo, P, Donal, E, Lourenco Marmelo, B F, Faria, R, Magalhaes, P, Marques, N, Domingues, K, Lourenco, C, Almeida, AR, Teles, L, Picarra, B, Azevedo, O, SUNSHINE, Grupo, Reis, L, Lourenco, C, Oliveira, M, Magalhaes, P, Domingues, K, Marmelo, B, Almeida, A, Picarra, B, Faria, R, Marques, N, Sunshine, Domingues, K, Bento, D, Lourenco, C, Magalhaes, P, Cruz, I, Marmelo, B, Reis, L, Picarra, B, Faria, R, Azevedo, O, group, Sunshine, Krestjyaninov, MV, Gimaev, RH, Melnikova, MA, Olezov, NV, Ruzov, VI, Mesquita, J, Goncalves, P, Almeida, M S, Branco, P, Carvalho, M S, Dores, H, Gaspar, M A, Sousa, H, Andrade, M J, Mendes, M, Ikonomidis, I, Makavos, G, Varoudi, M, Papadavid, E, Andreadou, I, Gravanis, K, Liarakos, N, Pavlidis, G, Rigopoulos, D, Lekakis, J, Ferferieva, V, Deluyker, D, Bito, V, Peluso, D, Pigatto, E, Romeo, G, Muraru, D, Cozzi, F, Punzi, L, Iliceto, S, Badano, LP, Peluso, D, Pigatto, E, Romeo, G, Muraru, D, Cozzi, F, Iliceto, S, Badano, LP, King, GJ, Neilan, T, Coen, K, Gannon, S, Bennet, K, Clarke, JG, D'ascenzi, F, Solari, M, Cameli, M, Focardi, M, Corrado, D, Bonifazi, M, Henein, M, Mondillo, S, Ferrera Duran, C, Gomez-Escalonilla, C, De Agustin, A, Egido, J, Islas, F, Simal, P, Gomez De Diego, JJ, Luaces, M, Macaya, C, Perez De Isla, L, Sormani, P, Zancanella, M, Rusconi, C, Musca, F, Santambrogio, G, De Chiara, B, Vallerio, P, Cairoli, R, Giannattasio, G, Moreo, A, Gonzalez Fernandez, O, Alvarez Ortega, C, Mori Junco, R, Caro Codon, J, Meras Colunga, P, Ponz De Antonio, I, Lopez Fernandez, T, Valbuena Lopez, S, Moreno Yanguela, M, Lopez-Sendon, JL, Tereshina, O, Surkova, E, Cambronero Cortinas, E, Bonanad-Lozano, C, Lopez-Lereu, MP, Monmeneu-Menadas, JV, Gavara, J, De Dios, E, Paya-Chaume, A, Escribano-Alarcon, D, Chorro-Gasco, FJ, Bodi-Peris, V, Kupczynska, K, Michalski, BW, Miskowiec, D, Kasprzak, JD, Lipiec, P, Carvalho, J F, Morgado, G, Caldeira, D, Cruz, I, Joao, I, Almeida, A R, Lopes, L, Fazendas, P, Cotrim, C, Pereira, H, Shivalkar, B, De Block, C, Buys, D, Salgado, R, Vrints, C, Van Gaal, L, Aghamohammadzadeh, R, Mctear, C, Irwin, RB, Cifra, B, Dragulescu, A, Friedberg, M, Mertens, L, Cifra, B, Dragulescu, A, Friedberg, M, Mertens, L, Bandera, F, Carbone, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Kuznetsov, VA, Krinochkin, DV, Yaroslavskaya, EI, Zaharova, EH, Pushkarev, GS, Van Zalen, JJ, Sugihara, C, Patel, NR, Sulke, AN, Lloyd, GW, Kochanowski, J, Piatkowski, R, Scislo, P, Grabowski, M, Marchel, M, Opolski, G, Goebel, B, Roland, H, Hamadanchi, A, Otto, S, Jung, C, Lauten, A, Figulla, HC, Poerner, TC, Ladeiras-Lopes, R, Sampaio, F, Fonseca, P, Fontes-Carvalho, R, Pinho, M, Campos, AS, Castro, P, Fonseca, C, Ribeiro, J, Gama, V, Goebel, B, Heck, R, Hamdanchi, A, Otto, S, Jung, C, Lauten, A, Figulla, HR, Poerner, TC, Karvandi, M, Ranjbar, S, Ghaffaripour Jahromi, M, Karvandi, M, Ranjbar, S, Alonso Salinas, G, Hinojar, R, Fernandez Golfin, C, Esteban, A, Pascual-Izco, M, Garcia-Martin, A, Casas Rojo, E, Jimenez-Nacher, JJ, Zamorano, JL, Unkun, T, Gecmen, C, Cap, M, Izci, S, Erdogan, E, Onal, C, Acar, R, Bakal, RB, Kaymaz, C, Ozdemir, N, Ranjbar, S, Karvandi, M, Ghaffaripour Jahromi, M, Hubert, A, Galand, V, Schnell, F, Matelot, D, Martins, R, Leclercq, C, Carre, F, Enescu, OA, Suran, BC, Margulescu, AD, Rimbas, RC, Siliste, C, Vinereanu, D, Liccardo, M, Nocerino, P, Urso, AC, Borrino, A, Carbone, C, Follero, P, Ciardiello, C, Prato, L, Salzano, G, Cameli, M, Marino, F, Ruspetti, A, Sparla, S, Di Tommaso, C, Loiacono, F, Focardi, M, D'ascenzi, F, Henein, M, Mondillo, S, Ako, E, Porter, J, Walker, M, Lembo, M, Lo Iudice, F, Esposito, R, Santoro, C, Cocozza, S, Izzo, R, De Luca, N, De Simone, G, Trimarco, B, Galderisi, M, Goffredo, C, Gervasi, F, Patti, G, Mega, S, Bono, M, Di Sciascio, G, Enache, R, Buture, A, Badea, R, Platon, P, Ghiorghiu, I, Jurcut, R, Coman, IM, Popescu, BA, Ginghina, C, Novo, G, Lunetta, M, Spoto, MS, Lo Vi, AM, Pensabene, G, Meschisi, MC, Carita, P, Coppola, G, Novo, S, Assennato, P, Wdowiak-Okrojek, K, Shim, A, Wejner-Mik, P, Kasprzak, JD, Lipiec, P, Nemes, A, Havasi, K, Domsik, P, Kalapos, A, Forster, T, Nemes, A, Piros, GA, Domsik, P, Kalapos, A, Lengyel, C, Orosz, A, Forster, T, Di Salvo, G, Bulbul, Z, Issa, Z, Al Sehly, A, Pergola, V, Oufi, S, Capotosto, L, Conde, Y, Cimino, E, Rinaldi, E, Ashurov, R, Ricci, S, Pergolini, M, Vitarelli, A, Caravaca, P, Lujan Valencia, JE, Chaparro, M, Garcia-Guerrero, A, Cristo Ropero, MJ, Izquierdo Bajo, A, Madrona, L, Recio-Mayoral, A, Maceira Gonzalez, A M, Monmeneu, JV, Igual, B, Lopez Lereu, P, Garcia, MP, Iriart, X, Selmi, W, Jalal, Z, Thambo, JB, Jug, B, Kosuta, D, and Fras, Z
Abstract: Background: Handheld ultrasound devices allow for a bedside screening although quantitative parameters are not easily obtained. We aim to assess the reliability of visual qualitative evaluation of left ventricle (LV) compared with standard quantitative evaluation with 2D transthoracic echocardiography (TTE). Methods: Two cardiologists have reviewed 135 consecutive standard TTE examinations. Both observers visually assessed LV size, hypertrophy (LVH) and ejection fraction (EF). LV diameter, volume, wall thickness and EF (Teichholz and Simpson) were also measured by both observers. Visual and quantitative agreement and inter and intraobserver variability were calculated. Results: Image quality allowed for evaluation of 130 examinations. Visually assessed EF compared with Simpson had better consistency (Intraclass correlation coefficient [ICC] 0,91 IC95% 0,88-0,94) than with Teichholz (ICC 0,75 IC95% 0,66-0,82). We have also observed good interobserver agreement regarding visually assessed EF (ICC 0,81 IC95% 0,71-0,87) and Simpson EF (ICC 0,80 IC95% 0,70-0,89) as well as good intraobserver agreement (visual EF: ICC 0,81 IC95% 0,74-0,86; Simpson: ICC 0,89 IC95% 0,84-0,93). Regarding LVH we found moderate agreement between visual and quantitative assessment (weighted Kappa [wK] 0,44 (IC95% 0,32-0,56)), moderate interobserver agreement for quantitative assessment (ICC 0,59 IC95% 0,44-0,71) and poor interobserver agreement for visual assessment (wK 0,19 IC95% 0,08-0,30). Intraobserver variability regarding LVH visual estimation was moderate (wK 0,40 IC95% 0,29-0,52) and regarding LVH quantification was good (ICC 0,78 IC95% 0,70-0,84). LVH was visually overestimated in 25% of examinations. Regarding LV size, we found poor agreement between visual assessment and its quantification with end-diastolic diameter (wK 0,22 IC95% 0,06-0,39) and moderate agreement between visual assessment and end-systolic LV volume (wK 0,62 IC95% 0,47-0,77). Interobserver agreement regarding quantitative volume assessment was good (ICC 0,90 IC95% 0,85-0,94) and regarding visual assessment was moderate (wK 0,43 IC95% 0,26-0,70). We found good intraobserver variability of volume measurement (wK 0,64 IC95% 0,50-0,78) and of visual size assessment (ICC 0,96 IC95% 0,94-0,97). Conclusions: Visual LVEF assessment is consistent with quantitative assessment and should be regarded as a reliable parameter that can be obtained from bedside examination with a handheld device. Visual assessment of LV size and wall thickness is less reliable than its quantification and should be confirmed with standard measurements.
Published: 2015
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11. Poster session 6: Saturday 6 December 2014, 08:30-12:30 * Location: Poster area

Author: Goirigolzarri Artaza, J, Gallego Delgado, M, Jaimes Castellanos, CP, Cavero Gibanel, MA, Pastrana Ledesma, MA, Alonso Pulpon, LA, Gonzalez Mirelis, J, Al Ansi, R Z, Sokolovic, S, Cerin, G, Szychta, W, Popa, B A, Botezatu, D, Benea, D, Manganiello, S, Corlan, A, Jabour, A, Igual Munoz, B, Osaca Asensi, JOA, Andres La Huerta, AALH, Maceira Gonzalez, AMG, Estornell Erill, JEE, Cano Perez, OCP, Sancho-Tello, MJSTDC, Alonso Fernandez, PAF, Sepulveda Sanchez, PSS, Montero Argudo, AMA, Palombo, C, Morizzo, C, Baluci, M, Kozakova, M, Panajotu, A, Karady, J, Szeplaki, G, Horvath, T, Tarnoki, DL, Jermendy, AL, Geller, L, Merkely, B, Maurovich-Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Moustafa, S, Mookadam, F, Youssef, M, Zuhairy, H, Connelly, M, Prieur, T, Alvarez, N, Ashikhmin, Y, Drapkina, O, Boutsikou, M, Demerouti, E, Leontiadis, E, Petrou, E, Karatasakis, G, Kozakova, M, Morizzo, C, Bianchi, V, Marchi, B, Federico, G, Palombo, C, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Goto, M, Uejima, T, Itatani, K, Pedrizzetti, G, Mada, RO, Daraban, AM, Duchenne, J, Voigt, JU, Chiu, D Y Y, Green, D, Johnstone, L, Sinha, S, Kalra, PA, Abidin, N, Group, Salford Vascular Research, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Nemes, A, Sasi, V, Gavaller, H, Kalapos, A, Domsik, P, Katona, A, Szucsborus, T, Ungi, T, Forster, T, Ungi, I, Pluchinotta, FR, Arcidiacono, C, Saracino, A, Carminati, M, Bussadori, C, Dahlslett, T, Karlsen, S, Grenne, B, Sjoli, B, Bendz, B, Skulstad, H, Smiseth, OA, Edvardsen, T, Brunvand, H, Vereckei, A, Szelenyi, ZS, Szenasi, G, Santoro, C, Galderisi, M, Niglio, T, Santoro, M, Stabile, E, Rapacciuolo, A, Spinelli, L, De Simone, G, Esposito, G, Trimarco, B, Hubert, S, Jacquier, A, Fromonot, J, Resseguier, C, Tessier, A, Guieu, R, Renard, S, Haentjiens, J, Lavoute, C, Habib, G, Menting, M E, Koopman, LP, Mcghie, JS, Rebel, B, Gnanam, D, Helbing, WA, Van Den Bosch, AE, Roos-Hesselink, JW, Shiino, K, Yamada, A, Sugimoto, K, Takada, K, Takakuwa, Y, Miyagi, M, Iwase, M, Ozaki, Y, Placido, R, Ramalho, A, Nobre E Menezes, M, Cortez-Dias, N, Goncalves, S, Guimaraes, T, Robalo Martins, S, Francisco, AR, Almeida, AG, Nunes Diogo, A, Hayashi, T, Itatani, K, Inuzuka, R, Shindo, T, Hirata, Y, Shimizu, N, Miyaji, K, Henri, C, Dulgheru, R, Magne, J, Kou, S, Davin, L, Nchimi, A, Oury, C, Pierard, L, Lancellotti, P, Kovalyova, O, Honchar, O, Tengku, WINDA, Ketaren, ANDRE, Mingo Santos, S, Monivas Palomero, V, Restrepo Cordoba, A, Rodriguez Gonzalez, E, Goirigolzarri Artaza, J, Sayago Silva, I, Garcia Lunar, I, Mitroi, C, Cavero Gibanel, M, Segovia Cubero, J, Ryu, SK, Park, JY, Kim, SH, Choi, JW, Goh, CW, Byun, YS, Choi, JH, Westholm, C, Johnson, J, Jernberg, T, Winter, R, Rio, P, Moura Branco, L, Galrinho, A, Pinto Teixeira, P, Viveiros Monteiro, A, Portugal, G, Pereira-Da-Silva, T, Afonso Nogueira, M, Abreu, J, Cruz Ferreira, R, Mazzone, A, Botto, N, Paradossi, U, Chabane, A, Francini, M, Cerone, E, Baroni, M, Maffei, S, Berti, S, Tatu-Chitoiu, G P, Deleanu, D, Macarie, C, Chioncel, O, Dorobantu, M, Udroiu, C, Calmac, L, Diaconeasa, A, Vintila, V, Vinereanu, D, investigators, RO-STEMI, Ghattas, A, Shantsila, E, Griffiths, H, Lip, GY, Galli, E, Guirette, Y, Daudin, M, Auffret, V, Mabo, P, Donal, E, Fabiani, I, Conte, L, Scatena, C, Barletta, V, Pratali, S, De Martino, A, Bortolotti, U, Naccarato, AG, Di Bello, V, Falanga, G, Alati, E, Di Giannuario, G, Zito, C, Cusma' Piccione, M, Carerj, S, Oreto, G, Dattilo, G, Alfieri, O, La Canna, G, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Cho, EJ, Park, S-J, Lim, HJ, Yoon, HR, Chang, S-A, Lee, S-C, Park, SW, Cengiz, B, Sahin, S T, Yurdakul, S, Kahraman, S, Bozkurt, A, Aytekin, S, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Venkateshvaran, A, Sola, S, Dash, P K, Thapa, P, Manouras, A, Winter, R, Brodin, LA, Govind, S C, Mizariene, V, Verseckaite, R, Bieseviciene, M, Karaliute, R, Jonkaitiene, R, Vaskelyte, J, Arzanauskiene, R, Janenaite, J, Jurkevicius, R, Rosner, S, Orban, M, Nadjiri, J, Lesevic, H, Hadamitzky, M, Sonne, C, Manganaro, R, Carerj, S, Cusma-Piccione, MC, Caprino, A, Boretti, I, Todaro, MC, Falanga, G, Oreto, L, D'angelo, MC, Zito, C, Le Tourneau, T, Cueff, C, Richardson, M, Hossein-Foucher, C, Fayad, G, Roussel, JC, Trochu, JN, Vincentelli, A, Obase, K, Weinert, L, Lang, R, Cavalli, G, Muraru, D, Miglioranza, MH, Addetia, K, Veronesi, F, Cucchini, U, Mihaila, S, Tadic, M, Lang, RM, Badano, L, Polizzi, V, Pino, PG, Luzi, G, Bellavia, D, Fiorilli, R, Chialastri, C, Madeo, A, Malouf, J, Buffa, V, Musumeci, F, Gripari, P, Tamborini, G, Bottari, V, Maffessanti, F, Carminati, C, Muratori, M, Vignati, C, Bartorelli, A, Alamanni, F, Pepi, M, Polymeros, S, Dimopoulos, A, Spargias, K, Karatasakis, G, Athanasopoulos, G, Pavlides, G, Dagres, N, Vavouranakis, E, Stefanadis, C, Cokkinos, DV, Pradel, S, Mohty, D, Magne, J, Darodes, N, Lavergne, D, Damy, T, Beaufort, C, Aboyans, V, Jaccard, A, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Ben Chaabene, A, Kamoun, S, Mrabet, K, Fennira, S, Zargouni, A, Kraiem, S, Jovanova, S, Arnaudova-Dezjulovic, F, Correia, C E, Cruz, I, Marques, N, Fernandes, M, Bento, D, Moreira, D, Lopes, L, Azevedo, O, GROUP, SUNSHINE, Keramida, K, Kouris, N, Kostopoulos, V, Psarrou, G, Giannaris, V, Olympios, CD, Marketou, M, Parthenakis, F, Kalyva, N, Pontikoglou, CH, Maragkoudakis, S, Zacharis, E, Patrianakos, A, Roufas, K, Papadaki, H, Vardas, P, Dominguez Rodriguez, F, Monivas Palomero, V, Mingo Santos, S, Arribas Rivero, B, Cuenca Parra, S, Zegri Reiriz, I, Vazquez Lopez-Ibor, J, Garcia-Pavia, P, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Nemes, A, Domsik, P, Kalapos, A, Forster, T, Serra, W, Lumetti, FL, Mozzani, FM, Del Sante, GDS, Ariani, AA, Corros, C, Colunga, S, Garcia-Campos, A, Diaz, E, Martin, M, Rodriguez-Suarez, ML, Leon, V, Fidalgo, A, Moris, C, De La Hera, JM, Kylmala, M M, Rosengard-Barlund, M, Groop, P H, Lommi, J, Bruin De- Bon, HACM, Bilt Van Der, IA, Wilde, AA, Brink Van Den, RBA, Teske, AJ, Rinkel, GJ, Bouma, BJ, Teixeira, R, Monteiro, R, Garcia, J, Silva, A, Graca, M, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Duszanska, A, Skoczylas, I, Kukulski, T, Polonski, L, Kalarus, Z, Choi, J-H, Park, JS, Ahn, JH, Lee, JW, Ryu, SK, Ahn, J, Kim, DH, Lee, HO, Przewlocka-Kosmala, M, Mlynarczyk, J, Rojek, A, Mysiak, A, Kosmala, W, Pellissier, A, Larochelle, E, Krsticevic, L, Baron, E, Le, V, Roy, A, Deragon, A, Cote, M, Garcia, D, Tournoux, F, Yiangou, K, Azina, C, Yiangou, A, Zitti, M, Ioannides, M, Ricci, F, Dipace, G, Aquilani, R, Radico, F, Cicchitti, V, Bianco, F, Miniero, E, Petrini, F, De Caterina, R, Gallina, S, Jardim Prista Monteiro, R, Teixeira, R, Garcia, J, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Chung, H, Kim, JY, Joung, B, Uhm, JS, Pak, HN, Lee, MH, Lee, KY, Ragab, AM, Abdelwahab, AMIR, Yazeed, YASER, El Naggar, WAEL, Spahiu, K, Spahiu, E, Doko, A, Liesting, C, Brugts, JJ, Kofflard, MJM, Kitzen, JJEM, Boersma, E, Levin, M-D, Coppola, C, Piscopo, G, Rea, D, Maurea, C, Caronna, A, Capasso, I, Maurea, N, Azevedo, O, Tadeu, I, Lourenco, M, Portugues, J, Pereira, V, Lourenco, A, Nesukay, E, Kovalenko, V, Cherniuk, S, Danylenko, O, Muhammedov, MB, Ahmedova, DM, Hojakuliyev, BG, Atayeva, D, Nemes, A, Domsik, P, Kalapos, A, Lengyel, C, Varkonyi, TT, Orosz, A, Forster, T, Castro, M, Abecasis, J, Dores, H, Madeira, S, Horta, E, Ribeiras, R, Canada, M, Andrade, MJ, Mendes, M, Morosin, M, Piazza, R, Leonelli, V, Leiballi, E, Pecoraro, R, Cinello, M, Dell' Angela, L, Cassin, M, Sinagra, G, Nicolosi, GL, Wierzbowska-Drabik, K, Hamala, P, Kasprzak, JD, O'driscoll, J, Rossato, C, Gargallo-Fernandez, P, Araco, M, Sharma, S, Sharma, R, Jakus, N, Baricevic, Z, Ljubas Macek, J, Skoric, B, Skorak, I, Velagic, V, Separovic Hanzevacki, J, Milicic, D, Cikes, M, Deljanin Ilic, M, Ilic, S, Kocic, G, Pavlovic, R, Stoickov, V, Ilic, V, Nikolic, LJ, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Labate, V, Bandera, F, Generati, G, Pellegrino, M, Donghi, V, Alfonzetti, E, Guazzi, M, Zakarkaite, D, Kramena, R, Aidietiene, S, Janusauskas, V, Rucinskas, K, Samalavicius, R, Norkiene, I, Speciali, G, Aidietis, A, Kemaloglu Oz, T, Ozpamuk Karadeniz, F, Akyuz, S, Unal Dayi, S, Esen Zencirci, A, Atasoy, I, Osken, A, Eren, M, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Sousa, P, Joao, I, Cotrim, C, Pereira, H, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Joao, I, Cotrim, C, Pereira, H, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, A, Yagasaki, H, Kawasaki, M, Tanaka, R, Minatoguchi, S, Houle, H, Warita, S, Ono, K, Noda, T, Watanabe, S, Minatoguchi, S, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Mornos, C, Cozma, D, Ionac, A, Mornos, A, Popescu, I, Ionescu, G, Pescariu, S, Melzer, L, Faeh-Gunz, A, Seifert, B, Attenhofer Jost, C H, Storve, S, Haugen, BO, Dalen, H, Grue, JF, Samstad, S, Torp, H, Ferrarotti, L, Maggi, E, Piccinino, C, Sola, D, Pastore, F, Marino, PN, Ranjbar, S, Karvandi, M, Hassantash, SA, Karvandi, M, Ranjbar, S, Tierens, S, Remory, I, Bala, G, Gillis, K, Hernot, S, Droogmans, S, Cosyns, B, Lahoutte, T, Tran, N, Poelaert, J, Al-Mallah, M, Alsaileek, A, Nour, K, Celeng, CS, Horvath, T, Kolossvary, M, Karolyi, M, Panajotu, A, Kitslaar, P, Merkely, B, Maurovich Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Aguiar Rosa, S, Ramos, R, Marques, H, Portugal, G, Pereira Da Silva, T, Rio, P, Afonso Nogueira, M, Viveiros Monteiro, A, Figueiredo, L, and Cruz Ferreira, R
Abstract: Introduction: The increase of left auricular volume (LAV) is a robust cardiovascular event predictor. Despite that echochardiography is more often used, cardiac MRI is considered more accurate. Our objetives are to validate "fast" LAV measures by MRI vs the considered gold standard (GS) and to compare Echo and MRI in a wide spectrum of patients. Methods: In a non-selected popullation with MRI study previously realized, we measured LAV by biplane method (BPMR) and by area-length in 4 chamber view (ALMR) and compared them with biplane (BPe) and discs method (MDDe) in 4 chamber view in echo. To validate MRI measurements, we measured LAV in short axis slices (Simpson Method, SM) in a group of patients and considered it the GS. Results: 186 patients were included (mean age 51 ± 17 age; 123 male; 14 in AF) with clinical indication of cardiac MRI (Philips 1,5 T). In 24 patients SM was calculated. 29% of cardiac MRI were considered normal. Mean underlying pathologies were myocardiopathy (27%), Ischemic myocardiopathy (17%), myopericarditis (10%), prior to AF ablation (4%), valvular disease (6%) and miscellaneous (7%). Excellent correlation was obtained between "fast" MRI measurements and SM in MRI (SM vs BPMR interclass correlation coefficient ICC=0.965 and SM vs ALMR, ICC=0.958; P<0.05) with low interobserver variability (ICC=0.983 for SM; ICC=0.949 for BPMR; ICC=0.931 for ALMR). "Fast" measurements by MRI showed stadistical correlation between them (CCI=0.910) (Figure). Correlation between Echo and MRI measures was only moderate. (BPRM vs BPe CCI=0,469 mean difference -30 ml; ALMR vs MDDe ICC=0,456 mean difference -24 mL). Conclusions: ‘fast’ LAV measures by MRI are comparable with the MRI GS and also between them. Echo values seem to underestimate compared to MRI, so its use may not be suitable.
Published: 2014
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12. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area

Author: Montoro Lopez, M, Iniesta Manjavacas, AM, Mori Junco, R, Pena Conde, L, Pons De Antonio, I, Garcia Blas, S, Lopez Fernandez, T, Moreno Gomez, R, Moreno Yanguela, M, Lopez Sendon, JL, Carro, A, Kiotsekoglou, A, Andoh, J, Brown, S, Kaski, JC, Imamura, Y, Arai, K, Uematsu, S, Fukushima, K, Hoshi, H, Ashihara, K, Takagi, A, Hagiwara, N, Gillis, K, Bala, G, Roosens, B, Remory, I, Droogmans, S, Van Camp, G, Cosyns, B, Van De Heyning, CM, Magne, J, Pierard, LA, Bruyere, PJ, Davin, L, De Maeyer, C, Paelinck, BP, Vrints, CJ, Lancellotti, P, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Janas, J, Szwed, H, Tufaro, V, Fragasso, G, Ingallina, G, Marini, C, Fisicaro, A, Loiacono, F, Margonato, A, Agricola, E, Ferreira, F, Pereira, TS, Abreu, J, Labandeiro, J, Fiarresga, A, Ferreira, AM, Galrinho, A, Branco, LM, Timoteo, AT, Ferreira, RC, Marmol, R, Gomez, M, Garcia, K, Sanmiguel, D, Cabades, C, Monteagudo, M, Nunez, C, Fernandez, C, Diez, JL, Roldan, I, Kolesnyk, MY, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Janas, J, Szwed, H, Marini, C, Tufaro, V, Ancona, MB, Fisicaro, A, Oppizzi, M, Margonato, A, Agricola, E, Krestjyaninov, M, Razin, VA, Gimaev, RH, Carminati, MC, Piazzese, C, Tsang, W, Lang, RM, Caiani, EG, Goncalves, S, Ramalho, A, Placido, R, Marta, L, Cortez Dias, N, Magalhaes, A, Menezes, M, Martins, S, Almeida, A, Nunes Diogo, A, Stokke, T M, Ruddox, V, Sarvari, S I, Otterstad, J E, Aune, E, Edvardsen, T, Pirone, D, De Francesco, V, Marino, F, Gervasi, F, Demartini, C, Goffredo, C, Bono, MC, Mega, S, Chello, M, Di Sciascio, G, Martin Hidalgo, M, Seoane Garcia, T, Carrasco Avalos, F, Mesa Rubio, MD, Delgado Ortega, M, Ruiz Ortiz, M, Mazuelos Bellido, F, Suarez De Lezo Herrero De Tejada, J, Pan Alvarez De Osorio, M, Suarez De Lezo Cruz Conde, J, Seoane Garcia, T, Martin Hidalgo, M, Carrasco Avalos, F, Mesa Rubio, MD, Ruiz Ortiz, M, Delgado Ortega, M, Lopez Granados, A, Romero Moreno, M, Pan Alvarez-Ossorio, M, Suarez De Lezo Cruz Conde, J, Menichetti, F, Bongiorni, MG, Ferro, B, Segreti, L, Bertini, P, Mariotti, R, Baldassarri, R, Di Cori, A, Zucchelli, G, Guarracino, F, Santoro, A, Federco Alvino, FA, Giovanni Antonelli, GA, Raffaella De Vito, RDV, Roberta Molle, RM, Sergio Mondillo, SM, Mahmoud, Y, Abdel-Kader, M, Guindy, R, Elzahwy, S, Dijkema, EJ, Molenschot, MC, Slieker, MG, Oliveira Da Silva, C, Sahlen, A, Winter, R, Back, M, Ruck, A, Settergren, M, Manouras, A, Shahgaldi, K, Krestjyaninov, MV, and Ruzov, VI
Abstract: Purpose: The coexistence of mitral regurgitation (MR) and severe aortic stenosis is a common problem in elderly patients that limits the indication for percutaneous aortic prosthesis (TAVI). However, recent publications indicate a decrease in MR after TAVI because of the improvement of left ventricle (LV) hemodynamic conditions. The aim of our study was to investigate clinical and echocardiographic predictors of MR after TAVI. Methods: We included patients undergoing TAVI from May 2008 to November 2012. It was performed a 3D transesophageal echocardiogram during the procedure and a transthoracic echocardiogram before discharge and 12 months after implantation. We studied the etiology of MR before procedure, LV ejection fraction, chambers volume, pulmonary hypertension and tricuspid regurgitation, as well as clinical and technical variables related to the procedure. Results: 90 patients underwent TAVI successfully (Table). At the beginning, 21% of patients had MR at least grade III/IV. After TAVI, 84.4% of patients showed no change in MR degree, 12.2% improved and only 3.3% worsened. Variables related with MR worsening were rheumatic MR etiology, history of atrial fibrillation (AF) and the coexistence of significant tricuspid regurgitation (TR) in the baseline study (p <0.04, p <0.01; p <0.03, respectively). Conclusions: In patients undergoing TAVI, the rheumatic etiology of MR, the previous history of AF and significant TR coexistence were factors related to MR worsening after the procedure. Baseline characteristics. N = 90Age81.9 ± 6.9Women49 (54.4%)LVEF56 % ± 11.6Previous stroke16 (18%)Previous AF36 (42.4%)Baseline creatinine serum level1.3 mg/dl ± 0.5EuroSCORE16.8 ± 9.2Transfemoral approach71 (79.8%)Transapical approach18 (20.2%) LVEF: ejection fraction of the left ventricle. AF: atrial fibrillation
Published: 2013
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13. The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke).

Author: Barca C, Foray C, Hermann S, Herrlinger U, Remory I, Laoui D, Schäfers M, Grauer OM, Zinnhardt B, and Jacobs AH
Subjects: Animals, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Brain Neoplasms immunology, Brain Neoplasms pathology, Disease Models, Animal, Disease Progression, Glioma immunology, Glioma pathology, Humans, Macrophages drug effects, Macrophages immunology, Macrophages metabolism, Microglia drug effects, Microglia immunology, Microglia pathology, Neuroinflammatory Diseases immunology, Neuroinflammatory Diseases pathology, Neuroprotective Agents pharmacology, Neuroprotective Agents therapeutic use, Receptor, Macrophage Colony-Stimulating Factor metabolism, Review Literature as Topic, Signal Transduction drug effects, Signal Transduction immunology, Stroke immunology, Stroke pathology, Brain Neoplasms drug therapy, Glioma drug therapy, Neuroinflammatory Diseases drug therapy, Receptor, Macrophage Colony-Stimulating Factor antagonists & inhibitors, Stroke drug therapy
Abstract: Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the innate immune response after infection or injury. In this context, the colony-stimulating factor 1 (CSF-1) and its receptor (CSF-1R) have gained attention in various neurological conditions to deplete and reprogram the microglia/macrophages compartment. Published data in physiological conditions support the use of small-molecule inhibitors to study microglia/macrophages dynamics under inflammatory conditions and as a therapeutic strategy in pathologies where those cells support disease progression. However, preclinical and clinical data highlighted that the complexity of the spatiotemporal inflammatory response could limit their efficiency due to compensatory mechanisms, ultimately leading to therapy resistance. We review the current state-of-art in the field of CSF-1R inhibition in glioma and stroke and provide an overview of the fundamentals, ongoing research, potential developments of this promising therapeutic strategy and further application toward molecular imaging., Competing Interests: The author BZ is currently employed by F. Hoffman-La Roche Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Barca, Foray, Hermann, Herrlinger, Remory, Laoui, Schäfers, Grauer, Zinnhardt and Jacobs.)
Published: 2021
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14. An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models.

Author: Schepens B, van Schie L, Nerinckx W, Roose K, Van Breedam W, Fijalkowska D, Devos S, Weyts W, De Cae S, Vanmarcke S, Lonigro C, Eeckhaut H, Van Herpe D, Borloo J, Oliveira AF, Catani JPP, Creytens S, De Vlieger D, Michielsen G, Marchan JCZ, Moschonas GD, Rossey I, Sedeyn K, Van Hecke A, Zhang X, Langendries L, Jacobs S, Ter Horst S, Seldeslachts L, Liesenborghs L, Boudewijns R, Thibaut HJ, Dallmeier K, Velde GV, Weynand B, Beer J, Schnepf D, Ohnemus A, Remory I, Foo CS, Abdelnabi R, Maes P, Kaptein SJF, Rocha-Pereira J, Jochmans D, Delang L, Peelman F, Staeheli P, Schwemmle M, Devoogdt N, Tersago D, Germani M, Heads J, Henry A, Popplewell A, Ellis M, Brady K, Turner A, Dombrecht B, Stortelers C, Neyts J, Callewaert N, and Saelens X
Subjects: Animals, Antibodies, Neutralizing, Antibodies, Viral, Humans, Models, Animal, SARS-CoV-2, COVID-19, Spike Glycoprotein, Coronavirus
Abstract: Broadly neutralizing antibodies are an important treatment for individuals with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody-based therapeutics are also essential for pandemic preparedness against future Sarbecovirus outbreaks. Camelid-derived single domain antibodies (VHHs) exhibit potent antimicrobial activity and are being developed as SARS-CoV-2–neutralizing antibody-like therapeutics. Here, we identified VHHs that neutralize both SARS-CoV-1 and SARS-CoV-2, including now circulating variants. We observed that the VHHs bound to a highly conserved epitope in the receptor binding domain of the viral spike protein that is difficult to access for human antibodies. Structure-guided molecular modeling, combined with rapid yeast-based prototyping, resulted in an affinity enhanced VHH-human immunoglobulin G1 Fc fusion molecule with subnanomolar neutralizing activity. This VHH-Fc fusion protein, produced in and purified from cultured Chinese hamster ovary cells, controlled SARS-CoV-2 replication in prophylactic and therapeutic settings in mice expressing human angiotensin converting enzyme 2 and in hamsters infected with SARS-CoV-2. These data led to affinity-enhanced selection of the VHH, XVR011, a stable anti–COVID-19 biologic that is now being evaluated in the clinic.
Published: 2021
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15. Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis - impact of radiochemistry on pharmacokinetics.

Author: Bala G, Crauwels M, Blykers A, Remory I, Marschall ALJ, Dübel S, Dumas L, Broisat A, Martin C, Ballet S, Cosyns B, Caveliers V, Devoogdt N, Xavier C, and Hernot S
Subjects: Animals, Gallium Radioisotopes, Indium Radioisotopes, Isotope Labeling, Mice, Mice, Inbred C57BL, Mice, Knockout, Single-Domain Antibodies immunology, Single-Domain Antibodies metabolism, Atherosclerosis diagnostic imaging, Molecular Imaging, Single-Domain Antibodies chemistry, Vascular Cell Adhesion Molecule-1 immunology
Abstract: Radiolabeling of nanobodies with radiometals by chelation has the advantage of being simple, fast and easy to implement in clinical routine. In this study, we validated 68Ga/111In-labeled anti-VCAM-1 nanobodies as potential radiometal-based tracers for molecular imaging of atherosclerosis. Both showed specific targeting of atherosclerotic lesions in ApoE-/- mice. Nevertheless, uptake in lesions and constitutively VCAM-1 expressing organs was lower than previously reported for the 99mTc-labeled analog. We further investigated the impact of different radiolabeling strategies on the in vivo biodistribution of nanobody-based tracers. Comparison of the pharmacokinetics between 68Ga-, 18F-, 111In- and 99mTc-labeled anti-VCAM-1 nanobodies showed highest specific uptake for 99mTc-nanobody at all time-points, followed by the 68Ga-, 111In- and 18F-labeled tracer. No correlation was found with the estimated number of radioisotopes per nanobody, and mimicking specific activity of other radiolabeling methods did not result in an analogous biodistribution. We also demonstrated specificity of the tracer using mice with a VCAM-1 knocked-down phenotype, while showing for the first time the in vivo visualization of a protein knock-down using intrabodies. Conclusively, the chosen radiochemistry does have an important impact on the biodistribution of nanobodies, in particular on the specific targeting, but differences are not purely due to the tracer's specific activity.
Published: 2019
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16. Evaluation of [ 99m Tc]Radiolabeled Macrophage Mannose Receptor-Specific Nanobodies for Targeting of Atherosclerotic Lesions in Mice.

Author: Bala G, Baudhuin H, Remory I, Gillis K, Debie P, Krasniqi A, Lahoutte T, Raes G, Devoogdt N, Cosyns B, and Hernot S
Subjects: Animals, Aorta diagnostic imaging, Aorta pathology, Autoradiography, Female, Humans, Mannose Receptor, Mice, Inbred C57BL, Staining and Labeling, Tissue Distribution, Lectins, C-Type metabolism, Macrophages metabolism, Mannose-Binding Lectins metabolism, Plaque, Atherosclerotic diagnostic imaging, Radiopharmaceuticals chemistry, Receptors, Cell Surface metabolism, Single-Domain Antibodies metabolism, Technetium chemistry
Abstract: Purpose: Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaque hemorrhage and neovascularization. It has been proposed as target to identify vulnerable plaques. Therefore, we aimed to assess the feasibility of using anti-MMR nanobodies (Nbs) as molecular tracers for nuclear imaging in an animal model of atherosclerosis., Procedure: Anti-MMR and control Nb, radiolabeled with Tc-99m, were injected in ApoE -/- and/or C57Bl/6 mice (n = 6). In vivo competition studies involving pre-injection of excess of unlabeled anti-MMR Nb (n = 3) and injection of anti-MMR Nb in MMR -/- mice (n = 3) were performed to demonstrate specificity. At 3 h p.i. radioactive uptake in organs, tissues and aorta segments were evaluated. Autoradiography and immunofluorescence were performed on aortic sections., Results: Significantly higher uptake was observed in all aortic segments of ApoE -/- mice injected with anti-MMR Nb compared to control Nb (1.36 ± 0.67 vs 0.38 ± 0.13 percent of injected dose per gram (%ID/g), p ≤ 0.001). Surprisingly, high aortic uptake was also observed in C57Bl/6 mice (1.50 ± 0.43%ID/g, p ≥ 0.05 compared to ApoE -/- ), while aortic uptake was reduced to background levels in the case of competition and in MMR -/- mice (0.46 ± 0.10 and 0.22 ± 0.06%ID/g, respectively; p ≤ 0.001). Therefore, expression of MMR along healthy aortas was suggested. Autoradiography showed no specific radioactive signal within atherosclerotic plaques, but rather localization of the signal along the aorta, correlating with MMR expression in perivascular tissue as demonstrated by immunofluorescence., Conclusions: No significant uptake of MMR-specific Nb could be observed in atherosclerotic lesions of ApoE -/- mice in this study. A specific perivascular signal causing a non-negligible background level was demonstrated. This observation should be considered when using MMR as a target in molecular imaging of atherosclerosis, as well as use of translational animal models with vulnerable plaques.
Published: 2018
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17. Clinical validation of an ultrasound quantification score for aortic valve calcifications.

Author: Gillis K, Bala G, Roosens B, Hernot S, Remory I, Scheirlynck E, Geers J, Droogmans S, and Cosyns B
Subjects: Aged, Aged, 80 and over, Aortic Valve diagnostic imaging, Female, Humans, Male, Middle Aged, Prospective Studies, Aortic Valve pathology, Aortic Valve Stenosis diagnostic imaging, Calcinosis diagnostic imaging, Echocardiography methods, Tomography, X-Ray Computed methods
Published: 2018
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18. Interaction of renal failure and dyslipidaemia in the development of calcific aortic valve disease in rats.

Author: Gillis K, Roosens B, Bala G, Remory I, Hernot S, Delvenne P, Mestrez F, Droogmans S, and Cosyns B
Subjects: Animals, Correlation of Data, Disease Models, Animal, Echocardiography methods, Rats, Rats, Wistar, Aortic Valve diagnostic imaging, Aortic Valve pathology, Calcinosis diagnosis, Calcinosis etiology, Calcinosis pathology, Dyslipidemias blood, Heart Valve Diseases diagnosis, Heart Valve Diseases etiology, Heart Valve Diseases pathology, Renal Insufficiency complications, Renal Insufficiency diagnosis
Abstract: Objective: Calcific aortic valve disease (CAVD) is currently the most common heart valve disease worldwide and is known to be an active process. Both renal failure and dyslipidaemia are considered to be promoting factors for the development of valvular calcifications. The aim of this study is to prospectively evaluate the respective contribution and interaction of renal failure and dyslipidaemia on CAVD in a rat model, using echocardiography and compared with histology., Methods and Results: Sixty-eight male Wistar rats were prospectively divided in eight groups, each fed a different diet to induce renal failure alone and combined with hyperlipidaemia or hypercholesterolemia. CAVD was detected and quantified by calibrated integrated backscatter of ultrasound (cIB) and compared with the histological calcium score. The study follow-up was 20 weeks. At the end of the study, the cIB value and the calcium score of the aortic valve were significantly increased in the group with isolated renal failure but not with dyslipidaemia. The combination of renal failure with high cholesterol or high-fat diet did not significantly increase calcifications further., Conclusions: Renal failure alone does induce aortic valve calcifications in a rat model of CAVD, whereas dyslipidaemia alone does not. The combination of renal failure with dyslipidaemia does not increase calcification further. These findings suggest that a combination of atherosclerotic and calcifying factors is not required to induce aortic valve calcifications in this model.
Published: 2017
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19. Quantification of Calcium Amount in a New Experimental Model: A Comparison between Ultrasound and Computed Tomography.

Author: Gillis K, Bala G, Roosens B, Remory I, Hernot S, Droogmans S, and Cosyns B
Subjects: Aortic Valve Stenosis diagnosis, Durapatite analysis, Humans, In Vitro Techniques, Models, Biological, Phantoms, Imaging, Ultrasonography, X-Ray Microtomography, Calcinosis diagnostic imaging
Abstract: Purpose: Calcification is an important prognostic factor in aortic valve stenosis. However, there is no ultrasound (US) method available to accurately quantify calcification in this setting to date. We aimed to validate a new US method for measuring the amount of calcium in an in vitro model, and compare it to computed tomography (CT), the current imaging gold standard., Materials and Methods: An agar phantom (2% agar) was made, containing 9 different amounts of calcium-hydroxyapatite Ca5(PO4)3OH (2 to 50 mg). The phantoms were imaged with micro-CT and US (10 MHz probe). The calcium area (areacalcium) and its maximum pixel value (PVmax) were obtained. These values were summed to calculate CT and US calcium scores (∑(areacalcium × PVmax)) and volumes (∑areacalcium). Both US- and CT-calcium scores were compared with the calcium amounts, and with each other., Results: Both calcium scores correlated significantly with the calcium amount (R2 = 0.9788, p<0.0001 and R2 = 0.8154, p<0.0001 for CT and US respectively). Furthermore, there was a significant correlation between US and CT for calcium volumes (R2 = 0.7392, p<0.0001) and scores (R2 = 0.7391, p<0.0001)., Conclusion: We developed a new US method that accurately quantifies the amount of calcium in an in vitro model. Moreover it is strongly correlated with CT.
Published: 2016
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20. Echocardiographic integrated backscatter for the differentiation between aortic valve calcification and valvular myxoid degeneration in rats.

Author: Gillis K, Bala G, Roosens B, Remory I, De Raeve H, Tierens S, Hernot S, Van Camp G, Droogmans S, and Cosyns B
Subjects: Animals, Aortic Valve diagnostic imaging, Diagnosis, Differential, Disease Models, Animal, Male, Rats, Rats, Wistar, Aortic Valve pathology, Aortic Valve Stenosis diagnostic imaging, Calcinosis diagnostic imaging, Echocardiography methods, Heart Valve Diseases diagnostic imaging
Abstract: Aims: Calcification is an independent predictor of mortality in aortic valve (AV) stenosis. Echocardiographic calibrated integrated backscatter (cIB) is a promising parameter for quantifying AV calcification. However, the ability of cIB to differentiate between calcification and valvular thickening has been questioned. Therefore, we aimed to use cIB to study AV calcification compared with non-calcified AV thickening in rats, with histology as reference., Methods and Results: Twenty male Wistar rats were studied. Group 1 (N = 6) received subcutaneous (SC) serotonin injections (60 mg/kg/day) for 12 weeks to induce myxoid non-calcified AV thickening. Group 2 (N = 7) received vitamin D3 (25,000 UI/kg/day) SC to induce AV calcification, and Group 3 (N = 7) received only vehicle SC for 10 weeks. cIB of the AV was calculated at the end of the study, followed by measurement of the percentage of the histological AV calcification. At the end of the study, cIB values and calcification percentages were significantly higher in vitamin D3-injected rats compared with serotonin-injected rats and controls. There was no significant difference in cIB values between serotonin-injected rats and controls (vitamin D3: 21.5 ± 3.0 dB*; serotonin: 11.8 ± 3.1 dB; control: 10.3 ± 3.4 dB; *P < 0.05). The percentage of histological calcification was significantly higher in the vitamin D3 group compared with the other groups. Serotonin-injected rats developed significant AV thickening., Conclusion: Increased cIB values of the AV are related to increased calcification at histology and not to myxoid non-calcified valvular thickening. Therefore, cIB may be considered as a sensitive technique to quantify calcification of AV rather than for detecting non-calcified valvular thickening., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)
Published: 2014
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21. Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats.

Author: Roosens B, Bala G, Gillis K, Remory I, Droogmans S, Somja J, Delvenne E, De Nayer J, Schiettecatte J, Delvenne P, Lancellotti P, Van Camp G, and Cosyns B
Subjects: Animals, Disease Models, Animal, Disease Progression, Male, Rats, Rats, Wistar, Aortic Valve diagnostic imaging, Calcinosis diagnostic imaging, Cardiomyopathies diagnostic imaging, Echocardiography methods, Heart Valve Diseases diagnostic imaging
Abstract: Background: Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology., Methods: 28 male Wistar rats were prospectively followed during 21 weeks. Group 1 (N=14) was fed with a 0.5% adenine diet for 9 weeks to induce renal failure and CAVD. Group 2 (N=14) received a standard diet. At week 9, six animals of each group were killed. The remaining animals of group 1 (N=8) and group 2 (N=8) were kept on a standard diet for an additional 12 weeks. cIB of the aortic valve was calculated at baseline, 9 and 21 weeks, followed by measurement of the calcified area (Ca Area) on histology., Results: At week 9, cIB values and Ca Area of the aortic valve were significantly increased in the adenine-fed rats compared to baseline and controls. After 12 weeks of adenine diet cessation, cIB values and Ca Area of group 1 decreased compared to week 9, while there was no longer a significant difference compared to age-matched controls of group 2., Conclusions: cIB is a non-invasive tool allowing quantitative monitoring of CAVD progression and regression in a rat model of reversible renal failure, as validated by comparison with histology. This technique might become useful for assessing CAVD during targeted therapy.
Published: 2013
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22. Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging.

Author: Keyaerts M, Remory I, Caveliers V, Breckpot K, Bos TJ, Poelaert J, Bossuyt A, and Lahoutte T
Subjects: Anesthesia, Anesthetics, General administration & dosage, Animals, Area Under Curve, Cell Extracts, Cell Line, Enzyme Inhibitors administration & dosage, Ethanol administration & dosage, Ethanol analogs & derivatives, Ethanol pharmacology, Humans, Injections, Ketamine administration & dosage, Ketamine pharmacology, Luciferases, Firefly metabolism, Male, Medetomidine administration & dosage, Medetomidine pharmacology, Mice, Mice, Nude, Pentobarbital administration & dosage, Pentobarbital pharmacology, Photons, Volatilization drug effects, Xylazine administration & dosage, Xylazine pharmacology, Anesthetics, General pharmacology, Enzyme Inhibitors pharmacology, Imaging, Three-Dimensional methods, Luciferases, Firefly antagonists & inhibitors, Luminescent Measurements methods
Abstract: Unlabelled: Bioluminescence imaging is routinely performed in anesthetized mice. Often isoflurane anesthesia is used because of its ease of use and fast induction/recovery. However, general anesthetics have been described as important inhibitors of the luciferase enzyme reaction., Aim: To investigate frequently used mouse anesthetics for their direct effect on the luciferase reaction, both in vitro and in vivo., Materials and Methods: isoflurane, sevoflurane, desflurane, ketamine, xylazine, medetomidine, pentobarbital and avertin were tested in vitro on luciferase-expressing intact cells, and for non-volatile anesthetics on intact cells and cell lysates. In vivo, isoflurane was compared to unanesthetized animals and different anesthetics. Differences in maximal photon emission and time-to-peak photon emission were analyzed., Results: All volatile anesthetics showed a clear inhibitory effect on the luciferase activity of 50% at physiological concentrations. Avertin had a stronger inhibitory effect of 80%. For ketamine and xylazine, increased photon emission was observed in intact cells, but this was not present in cell lysate assays, and was most likely due to cell toxicity and increased cell membrane permeability. In vivo, the highest signal intensities were measured in unanesthetized mice and pentobarbital anesthetized mice, followed by avertin. Isoflurane and ketamine/medetomidine anesthetized mice showed the lowest photon emission (40% of unanesthetized), with significantly longer time-to-peak than unanesthetized, pentobarbital or avertin-anesthetized mice. We conclude that, although strong inhibitory effects of anesthetics are present in vitro, their effect on in vivo BLI quantification is mainly due to their hemodynamic effects on mice and only to a lesser extent due to the direct inhibitory effect.
Published: 2012
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1. Poster session 6: Saturday 6 December 2014, 08: 30–12: 30Location: Poster area

2. Club35 Poster Session Thursday 12 December: 12/12/2013, 08: 30–18: 00Location: Poster area

3. Assessment of intraoperative microaspiration: does a modified cuff shape improve sealing?

6. Echocardiographic integrated backscatter for the differentiation between aortic valve calcification and valvular myxoid degeneration in rats

7. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area

8. Assessment of intraoperative microaspiration: does a modified cuff shape improve sealing?

9. Poster session 6

10. Poster session 5

11. Poster session 6: Saturday 6 December 2014, 08:30-12:30 * Location: Poster area

12. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area

13. The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke).

14. An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models.

15. Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis - impact of radiochemistry on pharmacokinetics.

16. Evaluation of [ 99m Tc]Radiolabeled Macrophage Mannose Receptor-Specific Nanobodies for Targeting of Atherosclerotic Lesions in Mice.

17. Clinical validation of an ultrasound quantification score for aortic valve calcifications.

18. Interaction of renal failure and dyslipidaemia in the development of calcific aortic valve disease in rats.

19. Quantification of Calcium Amount in a New Experimental Model: A Comparison between Ultrasound and Computed Tomography.

20. Echocardiographic integrated backscatter for the differentiation between aortic valve calcification and valvular myxoid degeneration in rats.

21. Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats.

22. Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging.

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