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The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke).
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Dec 07; Vol. 12, pp. 787307. Date of Electronic Publication: 2021 Dec 07 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the innate immune response after infection or injury. In this context, the colony-stimulating factor 1 (CSF-1) and its receptor (CSF-1R) have gained attention in various neurological conditions to deplete and reprogram the microglia/macrophages compartment. Published data in physiological conditions support the use of small-molecule inhibitors to study microglia/macrophages dynamics under inflammatory conditions and as a therapeutic strategy in pathologies where those cells support disease progression. However, preclinical and clinical data highlighted that the complexity of the spatiotemporal inflammatory response could limit their efficiency due to compensatory mechanisms, ultimately leading to therapy resistance. We review the current state-of-art in the field of CSF-1R inhibition in glioma and stroke and provide an overview of the fundamentals, ongoing research, potential developments of this promising therapeutic strategy and further application toward molecular imaging.<br />Competing Interests: The author BZ is currently employed by F. Hoffman-La Roche Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Barca, Foray, Hermann, Herrlinger, Remory, Laoui, Schäfers, Grauer, Zinnhardt and Jacobs.)
- Subjects :
- Animals
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Brain Neoplasms immunology
Brain Neoplasms pathology
Disease Models, Animal
Disease Progression
Glioma immunology
Glioma pathology
Humans
Macrophages drug effects
Macrophages immunology
Macrophages metabolism
Microglia drug effects
Microglia immunology
Microglia pathology
Neuroinflammatory Diseases immunology
Neuroinflammatory Diseases pathology
Neuroprotective Agents pharmacology
Neuroprotective Agents therapeutic use
Receptor, Macrophage Colony-Stimulating Factor metabolism
Review Literature as Topic
Signal Transduction drug effects
Signal Transduction immunology
Stroke immunology
Stroke pathology
Brain Neoplasms drug therapy
Glioma drug therapy
Neuroinflammatory Diseases drug therapy
Receptor, Macrophage Colony-Stimulating Factor antagonists & inhibitors
Stroke drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34950148
- Full Text :
- https://doi.org/10.3389/fimmu.2021.787307