Author: "Region Bretagne" - Searchworks@Jio Institute Digital Library Search Results

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456 results on '"Region Bretagne"'

1. Contamination des eaux et des poissons par les pesticides dans les rivieres de l'ouest

Author: Giovanni, R., Prefecture de La Region Bretagne, ., Comite Technique de L'Eau, ., Cellule d'Orientation Régionale Pour La Protection Des Eaux Contre Les Pesticides, ., Ecobiologie et qualité des hydrosystèmes continentaux (EQHC), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), Préfecture de la Région Bretagne, Partenaires INRAE, Comite Technique de l'Eau, Cellule d'Orientation Régionale pour la Protection des Eaux contre les Pesticides, and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract: *INRA, Laboratoire d'Ecologie Aquatique, 65, rue de St.Brieuc, 35042 Rennes Diffusion du document : INRA, Laboratoire d'Ecologie Aquatique, 65, rue de St.Brieuc, 35042 Rennes
Published: 1994

2. Insights into the ribosomal trans ‐translation rescue system: lessons from recent structural studies

Author: Gaetano D’Urso, Charlotte Guyomar, Sophie Chat, Emmanuel Giudice, Reynald Gillet, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Agence Nationale pour la Recherche, RIBOTARGET under the JPI AMR framework French National Research Agency (ANR) [18-JAM2-0005-03], French Direction Generale de l'Armement French National Research Agency (ANR), Universite de Rennes 1, European Union's ERASMUS+ program, Region Bretagne Region Bretagne, and ANR-18-JAM2-0005,RIBOTARGET(2018)
Subjects: tmRNA, ribosome, [SDV]Life Sciences [q-bio], cryo-EM, Cell Biology, SmpB, Molecular Biology, Biochemistry, trans-translation
Abstract: International audience; The arrest of protein synthesis caused when ribosomes stall on an mRNA lacking a stop codon is a deadly risk for all cells. In bacteria, this situation is remedied by the trans-translation quality control system. Trans-translation occurs because of the synergistic action of two main partners, transfer-messenger RNA (tmRNA) and small protein B (SmpB). These act in complex to monitor protein synthesis, intervening when necessary to rescue stalled ribosomes. During this process, incomplete nascent peptides are tagged for destruction, problematic mRNAs are degraded and the previously stalled ribosomes are recycled. In this 'Structural Snapshot' article, we describe the mechanism at the molecular level, a view updated after the most recent structural studies using cryo-electron microscopy.
Published: 2022
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3. Dispiroacridine-indacenobisthiophene positional isomers: impact of the bridge on the physicochemical properties

Author: Bertrand Donnio, Jean-David Peltier, Joëlle Rault-Berthelot, Benoît Heinrich, Nicolas Leclerc, Cyril Poriel, Thomas Heiser, Olzhas A. Ibraikulov, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Region Bretagne Region Bretagne, Agence de l'Environnement et de la Maitrise de l'Energie (ADEME), CNRS Centre National de la Recherche Scientifique (CNRS) European Commission, Universite de Strasbourg (UNISTRA), GENCI [2021-A0100805032], poriel, cyril, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE)
Subjects: Materials science, business.industry, 02 engineering and technology, Structural engineering, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Bridge (interpersonal), 0104 chemical sciences, [CHIM] Chemical Sciences, Materials Chemistry, Structural isomer, [CHIM]Chemical Sciences, General Materials Science, 0210 nano-technology, business
Abstract: International audience; We report the influence of positional isomerism on the electronic (electrochemical HOMO/LUMO energy levels), photophysical and physical properties (molecular organization, crystallinity and phase transitions) and charge transport properties of dispiroacridine-indacenobisthiophene positional isomers. The isomers differ from the central indacenobisthiophene (IDT) core, which displays either para or meta linkages. We show that the spiro-connected phenylacridine bridges have a significant influence on all these properties and particularly on the charge transport mobility values, which were found to be higher in the meta isomer than in the para isomer. This finding is different to what was reported in the literature for the other couples of IDT-based isomers and shows the key role played by the spiro-connected fragments in these molecular systems.
Published: 2022
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4. From taxonomic to functional dark diversity: Exploring the causes of potential biodiversity and its implications for conservation

Author: Frédéric Ysnel, Simon Chollet, Lou Barbe, Vincent Jung, Lo iumls Morel, Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Region Bretagne, Departement des Cotes d'Armor Region Bretagne, Departement d'Ille-et-Vilaine, Communaute de communes de Plouha-Lanvollon, Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)
Subjects: passive rewilding, 0106 biological sciences, genetic structures, Functional features, ecological restoration, Biodiversity, Woodland, forest temporal continuity, 010603 evolutionary biology, 01 natural sciences, Conservation, spiders, Restoration ecology, taxonomic and functional dark diversity, Ecology, plants, 010604 marine biology & hydrobiology, respiratory system, 15. Life on land, Geography, Habitat, community assembly, sense organs, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, human activities, Diversity (business)
Abstract: Aims and context: Dark diversity is an emerging and promising concept proposed to estimate the recruitment potential of natural communities and guide conservation and restoration policies. It represents all the species that could be present in a community due to favourable environmental conditions, but are currently lacking. To date, experimental approaches only measured taxonomic dark diversity, mainly based on species coexistence, which relies partly on neutral processes. Thus, these approaches may fail to identify the biodiversity which is lacking for deterministic reasons, and can hence hardly bring out suitable restoration methods. Methods: Here, we propose a novel method to estimate dark diversity, which is based on more deterministic coexistence: the coexistence of functional features. We adapted the Beals co-occurrence index using functional groups, and we estimated functional dark diversity based on coexistence of functional groups. We then made use of functional dark diversity to address a persistent issue of restoration ecology: how does passive rewilding impact the ecological integrity of recovered communities? We compared spontaneous, secondary woodlands with ancient forests, in terms of taxonomic and functional dark diversity of vascular plants and spiders. Results: Our results indicated that functional dark diversity does not equate to taxonomic dark diversity. Considering plants, recent woodlands surprisingly harboured less functional dark diversity than ancient forests, while they had a very similar amount of taxonomic dark diversity. Concerning spiders, recent woodlands harboured a similar amount of functional dark diversity as ancient forests, but more taxonomic dark diversity. Also, the composition of functional dark diversity differed between forest types, shedding light on their past assembly processes and unveiling their potential for conservation and effective restoration. Synthesis: Functional dark diversity brings novel perspectives for ecological diagnostic and restoration. Combined to taxonomic dark diversity, it enables to identify easily the deterministic constrains which limit the re-assembly of ecological communities after land-use changes and to predict the realistic, possible establishments of functional features. Here, we showed that spontaneous woodlands can have very similar, sometimes even higher, ecological integrity than that of ancient forests, and hence may be valuable habitats to be conserved from an ecological perspective.
Published: 2021
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5. Obesogenic diet leads to luminal overproduction of the complex IV inhibitor H 2 S and mitochondrial dysfunction in mouse colonocytes

Author: Thomas Guerbette, Martin Beaumont, Mireille Andriamihaja, Vincent Ciesielski, Jean‐Baptiste Perrin, Régis Janvier, Gwénaëlle Randuineau, Patricia Leroyer, Olivier Loréal, Vincent Rioux, Gaëlle Boudry, Annaïg Lan, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), TG was partly funded by Region Bretagne (grant no. 300000592)., Département Alimentation Humaine - INRAE (ALIM-H), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Region Bretagne (grant no. 300000592)
Subjects: obesity, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, high fat diet, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, Biochemistry, mitochondria, Genetics, microbiota, Molecular Biology, intestine, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Biotechnology
Abstract: International audience; Obesity is characterized by systemic low-grade inflammation associated with disturbances of intestinal homeostasis and microbiota dysbiosis. Mitochondrial metabolism sustains epithelial homeostasis by providing energy to colonic epithelial cells (CEC) but can be altered by dietary modulations of the luminal environment. Our study aimed at evaluating whether the consumption of an obesogenic diet alters the mitochondrial function of CEC in mice. Mice were fed for 22 weeks with a 58% kcal fat diet (diet-induced obesity [DIO] group) or a 10% kcal fat diet (control diet, CTRL). Colonic crypts were isolated to assess mitochondrial function while colonic content was collected to characterize microbiota and metabolites. DIO mice developed obesity, intestinal hyperpermeability, and increased endotoxemia. Analysis of isolated colonic crypt bioenergetics revealed a mitochondrial dysfunction marked by decreased basal and maximal respirations and lower respiration linked to ATP production in DIO mice. Yet, CEC gene expression of mitochondrial respiration chain complexes and mitochondrial dynamics were not altered in DIO mice. In parallel, DIO mice displayed increased colonic bile acid concentrations, associated with higher abundance of Desulfovibrionaceae. Sulfide concentration was markedly increased in the colon content of DIO mice. Hence, chronic treatment of CTRL mouse colon organoids with sodium sulfide provoked mitochondrial dysfunction similar to that observed in vivo in DIO mice while acute exposure of isolated mitochondria from CEC of CTRL mice to sodium sulfide diminished complex IV activity. Our study provides new insights into colon mitochondrial dysfunction in obesity by revealing that increased sulfide production by DIO-induced dysbiosis impairs complex IV activity in mouse CEC.
Published: 2023
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6. On the benefits of self-taught learning for brain decoding

Author: Elodie Germani, Elisa Fromont, Camille Maumet, Neuroimagerie: méthodes et applications (EMPENN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAL, IMAGE ET LANGAGE (IRISA-D6), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Large Scale Collaborative Data Mining (LACODAM), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-GESTION DES DONNÉES ET DE LA CONNAISSANCE (IRISA-D7), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Region Bretagne (ARED MAPIS), ANR-20-THIA-0018,AI4SDA,IA pour l'analyse de données sémantiques(2020), and Region Bretagne (ARED-MAPIS)
Subjects: FOS: Computer and information sciences, Computer Science - Artificial Intelligence, [SCCO.NEUR]Cognitive science/Neuroscience, Computer Science - Neural and Evolutionary Computing, Convolutional Neural Network, Health Informatics, Autoencoder, Brain Decoding, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], Computer Science Applications, Deep Learning, Artificial Intelligence (cs.AI), Self-taught Learning, [INFO]Computer Science [cs], Neural and Evolutionary Computing (cs.NE)
Abstract: Context We study the benefits of using a large public neuroimaging database composed of functional magnetic resonance imaging (fMRI) statistic maps, in a self-taught learning framework, for improving brain decoding on new tasks. First, we leverage the NeuroVault database to train, on a selection of relevant statistic maps, a convolutional autoencoder to reconstruct these maps. Then, we use this trained encoder to initialize a supervised convolutional neural network to classify tasks or cognitive processes of unseen statistic maps from large collections of the NeuroVault database. Results We show that such a self-taught learning process always improves the performance of the classifiers, but the magnitude of the benefits strongly depends on the number of samples available both for pretraining and fine-tuning the models and on the complexity of the targeted downstream task. Conclusion The pretrained model improves the classification performance and displays more generalizable features, less sensitive to individual differences.
Published: 2022
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7. ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

Author: Anne-Gaëlle Rio, Zi-Ling Liu, Virginie Gandemer, Aurélien A. Sérandour, Benoit Soubise, Marie-Dominique Galibert, Hana Raslova, Jason S. Carroll, Laurent Corcos, Jocelyne Demengeot, Nathalie Douet-Guilbert, Lydie Debaize, Jérémie Rouger-Gaudichon, Marie-Bérengère Troadec, Gilles Salbert, Yan Jiang, David Gilot, Hélène Jakobczyk, Stéphane Avner, Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Jilin University (JLU), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), University of Cambridge [UK] (CAM), Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chemistry, Oncogenesis, Stress and Signaling (COSS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Instituto Gulbenkian de Ciência [Oeiras] (IGC), Fundação Calouste Gulbenkian, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Pontchaillou [Rennes], Ligue Regionale contre le cancerLigue nationale contre le cancer [22, 29, 35, 56, 79, 41], Region Bretagne Region Bretagne, Societe Francaise d'Hematologie, Rennes Metropole Region Bretagne, societe francaise de lutte contre les cancers et les leucemies de l'enfant et de l'adolescent, Federation Enfants et Sante, AVIESAN Plan Cancer, Halte au Cancer, Association Gaetan Saleun, Mrs. M-Dominique Blanc-Bert, Canceropole Grand Ouest, Societe Francaise de Biochimie et Biologie Moleculaire, People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme [291851], European Project: 291851,EC:FP7:PEOPLE,FP7-PEOPLE-2011-CIG,ALLRUN(2012), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chard-Hutchinson, Xavier, and Modeling TEL/AML1 childhood lymphoblastic leukemia in zebrafish - ALLRUN - - EC:FP7:PEOPLE2012-02-01 - 2016-01-31 - 291851 - VALID
Subjects: Cancer Research, Letter, Oncogene Proteins, Fusion, [SDV]Life Sciences [q-bio], Recombination-activating gene, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Etv6 runx1, Tumor Cells, Cultured, Humans, Leukaemia, Medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Homeodomain Proteins, 0303 health sciences, Gene Expression Regulation, Leukemic, business.industry, Hematology, B-cell acute lymphoblastic leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, [SDV] Life Sciences [q-bio], Cell Transformation, Neoplastic, Oncology, RUNX1, chemistry, 030220 oncology & carcinogenesis, Core Binding Factor Alpha 2 Subunit, Cancer research, business, Haematological diseases
Abstract: Funder: Société Française de Biochimie et Biologie Moléculaire ; French Research Ministry, Funder: Cancéropole Grand Ouest ; Région Bretagne ; Société Française d’Hématologie, Funder: Ligue Régionale contre le cancer, ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression.
Published: 2021
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8. Product Detection of the CH(X2Π) Radical Reaction with Cyclopentadiene: A Novel Route to Benzene

Author: David L. Osborn, Sébastien D. Le Picard, Talitha M. Selby, Fabien Goulay, Kacee L. Caster, University of Wisconsin - Milwaukee, Sandia National Laboratories - Corporation, Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), West Virginia University [Morgantown], National Science Foundation (NSF) [CHE-1764178], Washington County Campus Foundation, Agence Nationale de la Recherche French National Research Agency (ANR) European Commission [ANR-11-BS04-024-CRESUSOL-01], French INSU/CNRS Program \'Physique et Chimie du Milieu Interstellaire\' (PCMI), Institut Nationalde Physique (INPCNRS), Region Bretagne Region Bretagne, Universite de Rennes 1, Institut Universitaire de France, Division of Chemical Sciences, Geosciences, and Biosciences, the Office of Basic Energy Sciences, the U.S. Department of EnergyUnited States Department of Energy (DOE), U.S. DOE's National Nuclear Security Administration National Nuclear Security Administration [DE-NA0003525], Office of Science, Office of Basic Energy Sciences, the U.S. Department of Energy at Lawrence Berkeley National Laboratory United States Department of Energy (DOE) [DE-AC02-05CH11231], ANR-11-BS04-0024,CRESUSOL,Cinétique et détermination des rapports de branchements de processus collisionnels à très basses températures(2011), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], Cyclopentadiene, 010304 chemical physics, Radical, Photoionization, 010402 general chemistry, 01 natural sciences, Cycloaddition, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Methylidyne radical, 0103 physical sciences, Potential energy surface, Physical chemistry, Physical and Theoretical Chemistry, Molecular physics, Benzene, Fulvene
Abstract: International audience; The reaction of the methylidyne radical (CH((XII)-I-2)) with cyclopentadiene (c-C5H6) is studied in the gas phase at 4 Ton and 373 K using a multiplexed photoionization mass spectrometer. Under multiple collision conditions, the dominant product channel observed is the formation of C6H6 + H. Fitting the photoionization spectrum using reference spectra allows for isomeric resolution of C6H6 isomers, where benzene is the largest contributor with a relative branching fraction of 90 (+/- 5)%. Several other C6H6 isomers are found to have smaller contributions, including fulvene with a branching fraction of 8 (+/- 5)%. Master Equation calculations for four different entrance channels on the C6H7 potential energy surface are performed to explore the competition between CH cycloaddition to a C=C bond vs CH insertion into C-H bonds of cyclopentadiene. Previous studies on CH addition to unsaturated hydrocarbons show little evidence for the C-H insertion pathway. The present computed branching fractions support benzene as the sole cyclic product from CH cycloaddition, whereas fulvene is the dominant product from two of the three pathways for CH insertion into the C-H bonds of cyclopentadiene. The combination of experiment with Master Equation calculations implies that insertion must account for similar to 10 (+/- 5)% of the overall CH + cyclopentadiene mechanism.
Published: 2021
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9. Structural and electronic properties of the metal cluster‐based compounds including high concentration of solvent molecules

Author: Fabien Grasset, Stéphane Cordier, Naoki Ohashi, Takeo Ohsawa, Yoshitaka Matsushita, Jeffrey S. Cross, Pierric Lemoine, Norio Saito, Tokyo Institute of Technology [Tokyo] (TITECH), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), National Institute for Materials Science (NIMS), Laboratory for Innovative Key Materials and Structures (LINK), SAINT-GOBAIN-National Institute of Materials Science-Centre National de la Recherche Scientifique (CNRS), NIMS, Saint-Gobain Company (Paris, France), Region Bretagne (France)Region Bretagne, CNRS, Rennes Univ, Fondation Langlois, Ministry of Education Science, Culture, Sports, Science and Technology via Elemental Strategy initiativeMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [JPMXP0112101001], Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Saint-Gobain-National Institute of Materials Science-Centre National de la Recherche Scientifique (CNRS)
Subjects: Molybdenum, Recrystallization (geology), 010405 organic chemistry, Chemistry, Space group, [CHIM.MATE]Chemical Sciences/Material chemistry, Crystal structure, Triclinic crystal system, 010402 general chemistry, Centrosymmetry, 01 natural sciences, Solid-state structures, Halides, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Inorganic Chemistry, Solvent, Crystallography, [CHIM.CRIS]Chemical Sciences/Cristallography, Molecule, Ab initio calculations, Cluster compounds, Single crystal
Abstract: International audience; Recrystallization of Cs-2[Mo6X14] (X=Cl, Br) was examined using typical organic solvents, i. e., methanol (CH3OH), acetone (CH3COCH3) and dichloromethane (CH2Cl2) in order to modify crystal structures and optoelectronic properties by promoting purity or inducing insertion of guest molecules. To this context, we performed recrystallization in solvent liquid and exposure of Cs-2[Mo6X14] to vapor of those solvents. Subsequent single crystal X-ray diffraction analyses revealed that three new types of compounds which contain high concentration of guest organic solvent molecules were obtained. Indeed, the newly found structures are Cs-2[Mo6Cl14] . 3CH(3)OH and Cs-2[Mo6X14] . 6CH(3)COCH(3) belonging to triclinic P1? space group, and Cs-2[Mo6X14] . 4CH(2)Cl(2) belonging to tetragonal P4/mnc space group. Although breaking of centrosymmetry by insertion of the guest molecule is interesting in terms of optoelectronic properties, all those new compounds belong to centrosymmetric space groups. As DFT calculations for those new compounds show that the guest molecules, such as CH3OH, do not affect the atomic arrangements and electronic features of the [Mo6X14](2-) cluster based unit, they incorporated with the lattice while keeping with the electrostatic interaction between the [Mo6X14](2-) and Cs+ ions regardless of the very high concentration of the guest solvent molecules.
Published: 2021
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10. Dynamic Control of the Shielding Effectiveness of Optically Transparent Screens

Author: Quentin Tricas, Xavier Castel, Philippe Besnier, Claire Le Paven, Patrice Foutrel, SAFRAN Electronics & Defense, Institut d'Électronique et des Technologies du numéRique (IETR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), SAFRAN Electronics and Defense [2018/1107], European Union European Commission, Ministry of Higher Education and Research Ministry of Higher Education and Scientific Research (MHESR), Region Bretagne Region Bretagne, Departement des Cotes d'Armor and Saint-Brieuc Armor Agglomeration, through the CPER Project 2015-2020 MATECOM, Departement des Cotes d'Armor and Saint-Brieuc Armor Agglomeration, through the CPER Project SOPHIE/STIC, and Departement des Cotes d'Armor and Saint-Brieuc Armor Agglomeration, through the CPER Project Ondes
Subjects: micrometric mesh metal film, p-i-n diode, shielding effectiveness, Electromagnetic shielding, Impedance, Condensed Matter Physics, Wires, reverberation chamber, Atomic and Molecular Physics, and Optics, high-intensity radiated fields (HIRFs), optical transparency, Transmission line measurements, [SPI]Engineering Sciences [physics], Metals, Optical sensors, Radio frequency, Electrical and Electronic Engineering, P-i-n diodes
Abstract: International audience; This article presents the design, fabrication, and characterization of an active electromagnetic shield intended to dynamically protect optical and electromagnetic sensors against high intensity radiated fields. The shield exhibits high and constant optical transparency level over the entire visible light spectrum thanks to a micrometric mesh metal thin film printed on a glass substrate. The central micrometric mesh area is separated from the peripheral ground plane of the shield by a peripheral slot. This slot is fitted out with p-i-n diodes and resistors, connecting electrically the central micrometric mesh area and the ground plane. The aim of these components is to dynamically control the shielding effectiveness of the screen, by using the conducting (ON) or blocking (OFF) states of the p-i-n diodes. Accordingly, the shielding effectiveness can be set at high level to protect the system against high intensity radiated fields, and conversely at low level to both prevent system electromagnetic self-perturbation and increase the sensitivity of the internal electromagnetic sensors. Dynamic control of the shielding effectiveness of the fabricated screen, whose optical transparency is close to 85% over the entire visible light spectrum, is fully demonstrated. A shielding effectiveness contrast ranging from 5 dB to 24 dB between the ON and OFF diode states was measured in the 2-10.5 GHz frequency range in a reverberation chamber.
Published: 2022
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11. Uncatalyzed Formation of Polyaminoboranes from Diisopropylaminoborane and Primary Amines: a Kinetically Controlled Polymerization Reaction

Author: Gilles Alcaraz, Elsa Caytan, Chiara Dinoi, Carlos Antonio De Albuquerque Pinheiro, Marc Devillard, Iker del Rosal, Claire Roiland, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Fédération de recherche « Matière et interactions » (FeRMI), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Brazilian Ministry of Education, CAPES, Region Bretagne Region Bretagne [17048], CALMIP Region Occitanie [2017-[p17010]], Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC), Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)
Subjects: Primary (chemistry), 010405 organic chemistry, aminoboranes, chemistry.chemical_element, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Monomer, BN compounds, Polymerization, chemistry, polymerization, Inorganic polymers, [CHIM]Chemical Sciences, boron, Boron, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Recently, we disclosed the uncatalyzed formation of polyaminoboranes (PABs) from monomeric diisopropylaminoborane ((Pr2N)-Pr-i-BH2) and primary amines (RNH2). Their structure is studied through a detailed multinuclear NMR study and their full spectroscopic characterization is presented revealing that N-alkyl substituted PABs exhibit magnetically non-equivalent methylenic protons in the close vicinity of the BN-backbone. We also performed an in-depth theoretical study of this global chemical process. The mechanism is fully apprehended and the strong influence of the temperature on the outcome of the reaction is unveiled. DFT-calculations clearly show that the formation of the polyaminoboranes (RNH-BH2)(n) results from a kinetically controlled step-growth polymerization reaction that can be globally viewed as a head-to-tail association process of the in situ generated transient monomeric monoalkylamino-borane [RNH-BH2].
Published: 2021
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12. Complex Epitaxy of Tetragonal Tungsten Bronze K–Ta–Nb–O Nanorods

Author: Loïc Joanny, Francis Gouttefangeas, Valérie Demange, Quentin Simon, Maryline Guilloux-Viry, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Synthèse Caractérisation Analyse de la Matière (ScanMAT), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), GREMAN (matériaux, microélectronique, acoustique et nanotechnologies) (GREMAN - UMR 7347), Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Region Bretagne, Rennes Metropole Region Bretagne, Departement d'Ille et Vilaine, European Union (CPER-FEDER 2007-2014) - European Union (EU) [39126, 37339], European Union (CPER 2015-2020 MULTIMAT ScanMAT), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Tours (UT)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut de Chimie du CNRS (INC), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010302 applied physics, Materials science, chemistry.chemical_element, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, General Chemistry, Substrate (electronics), Tungsten, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Epitaxy, 01 natural sciences, Ferroelectricity, Pulsed laser deposition, Tetragonal crystal system, Crystallography, thin films, chemistry, 0103 physical sciences, KTN, General Materials Science, Nanorod, Thin film, 0210 nano-technology, TTB
Abstract: International audience; Tetragonal tungsten bronze (TTB) phases possess numerous important properties (ferroelectricity, multiferroicity, piezoelectricity, optical nonlinearity, electro-optics) that can be achieved by modifying their composition, in addition to their ability to grow as very anisotropic crystals. In this study, K-5.06(Ta0.57Nb0.43)(10.99)O-30 tetragonal tungsten bronze phase thin films were grown by a pulsed laser deposition technique on (001)SrTiO3 and R-plane sapphire substrates. The films grew according to two modes with respect to the substrate surface, that is, as vertical nanorods with the [001] direction perpendicular to the substrate surface and as horizontal nanorods with the [001] orientation parallel to the substrate surface and < 310 > out-of-plane direction. Both vertical and horizontal nanorods present epitaxial relationships with the substrates. Careful study of epitaxial relationships showed a complex growth on both substrates that can be described in the framework of domain matching epitaxy resulting in several antiphase domain formations for both kinds of nanorods. These particular configurations are due to a high degree of coincidence between cations (anions) of the film with those of the substrate. This study shows the ability of ferroelectric TTB phases to grow as one-dimensional objects with the possibility to tailor their polarization direction either normal to or parallel to the substrate surface.
Published: 2020
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13. Relevant material characterization for load prediction in incremental forming

Author: A. Abdelkefi, D. Guines, L. Léotoing, S. Thuillier, Laboratoire de Génie Civil et Génie Mécanique (LGCGM), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Recherche Dupuy de Lôme (IRDL), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), and Region Bretagne Region Bretagne [SAD17027-Ti4FI]
Subjects: [SPI]Engineering Sciences [physics], Forming load, General Materials Science, Single point incremental forming, Titanium alloy, Mechanical behavior, Uniaxial and biaxial tension, Numerical model
Abstract: International audience; Robotic incremental sheet forming has arisen a recent industrial interest, as a more flexible and cost-effective solution to the process using rigid computer numerical control (CNC) machines. However, the numerical prediction of the forming loads and final geometry coupled to an elastic modeling of the robot is essential to optimize the robot trajectory and thus to ensure the geometrical accuracy of the final part. Within this context, the aim of this study is to investigate the accuracy of the load prediction in the case of a single point incremental forming process of a commercially pure (CP) titanium alloy sheet. The mechanical behavior is characterized at room temperature under two strain states, i.e., uniaxial and biaxial tension, and a truncated cone of the same material is obtained by single point incremental forming. A 3D cell records all the components of the applied load during the forming and the part is laser scanned at the end of the process, though still clamped along the outer edge. A numerical model of the process is developed assuming some symmetries to reduce the computational time. The influence of the hardening law, either identified from the uniaxial or biaxial tensile tests, on the forming load prediction is investigated, with a focus on the strain path during single point incremental forming.
Published: 2022
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14. Luminescent cyclometalated alkynylplatinum(ii) complexes with 1,3-di(pyrimidin-2-yl)benzene ligands: synthesis, electrochemistry, photophysics and computational studies

Author: Mariia Hruzd, Nicolas le Poul, Marie Cordier, Samia Kahlal, Jean-Yves Saillard, Sylvain Achelle, Sébastien Gauthier, Françoise Robin-le Guen, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie, Electrochimie Moléculaires et Chimie Analytique (CEMCA), Université de Brest (UBO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Region Bretagne, France Region Bretagne, and Conseil Departemental des Cotes d'Armor, France
Subjects: Inorganic Chemistry, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.COOR]Chemical Sciences/Coordination chemistry
Abstract: International audience; In this article, we report on a series of cyclometalated chloro- and alkynyl-platinum(ii) complexes bearing various tridentate NCN-cyclometalated ligands derived from 1,3-bis(pyrimidin-2-yl)benzene. The X-ray crystal structures of two alkynyl-platinum(ii) complexes were determined and other structures were DFT-calculated. Electrochemical and DFT-computational studies suggest a ligand-centred reduction on the R-1-substituted NCN ligand, whereas oxidation likely occurs either on the Pt-phenylacetylide moiety and/or the cyclometalated ligand. In CH2Cl2 solution at room temperature, the complexes show phosphorescent emissions ranging from green to orange, depending on the R-1 and R-2 substituents on the ligands. In KBr solid state matrix, excluding complexes bearing a trifluoromethyl substituted ligand, all compounds exhibit red emission. The presence of an alkynyl ancillary ligand has limited influence on absorption and emission spectra except in the case of the complex with the strongly electron-donating diphenylamino R-2 substituent on the alkynyl ligand, for which a significant red-shift was observed. The alkynyl Pt(ii) complex with OMe groups as both R-1 and R-2 substituents shows the best emission quantum yield (0.81 in CH2Cl2 solution) in this series. The full series of DFT calculated band gaps correlated generally well with the electrochemical and absorption data and reasonably model the impact of the substituents on the electronics of these complexes.
Published: 2022
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15. Quadruple Functionalization of a Tetraphenylethylene Aromatic Scaffold with Ynamides or Tetracyanobutadienes: Synthesis and Optical Properties

Author: Clotilde Philippe, Maëva Coste, Yann Bretonnière, Loïc Lemiègre, Sébastien Ulrich, Yann Trolez, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Agence Nationale pour la Recherche French National Research Agency (ANR) [ANR-17-CE070038-01, ANR-17-CE07-0042-01], Region Bretagne Region Bretagne, ANR-17-CE07-0038,Fluotet,Tétracyanobutadiènes fluorescents : de nouveaux AIEgènes pour des applications biophysiques(2017), ANR-17-CE07-0042,SELFBIOMAT,Auto-Assemblage Hiérarchique de BioMatériaux(2017), Ecole Nationale Supérieure de Chimie de Rennes (ENSCR), and Ecole normale supérieure de Lyon (Ens Lyon)
Subjects: Synthetic methods, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Tetracyanobutadienes, Organic Chemistry, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, Ynamides, Cycloaddition, Fluorescence
Abstract: International audience; Ynamides are useful and versatile building blocks in organic synthesis, from which 1,1,4,4-tetracyanobutadienes (TCBD) can be prepared for application in molecular electronics. However, their insertion onto multi-functional molecular scaffold remains a synthetic challenge. In this work, we report the two-steps synthesis in good isolated yield (64% overall, 89 degrees o stepwise) of a tetraphenylethylene (TPE) bearing four ynamides, and its further one-step conversion into the tetra-TCBD derivative through a [2 + 2] cycloaddition-retroelectrocyclization sequence. The concomitant formation of the four ynamides required a specific optimisation of the reaction conditions. Although a poor fluorescent emitter in solution, the tetra-TCBD compound displayed near-infrared luminescence in the solid state, which is an attractive optoelectronic feature when considering future applications in molecular electronic devices.
Published: 2022
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16. Structural and molecular bases to IRE1 activity modulation

Author: Nicolas Gouault, Timothy Langlais, Xavier Guillory, Eric Chevet, François Carreaux, Diana Pelizzari-Raymundo, Leif A. Eriksson, Sayyed Jalil Mahdizadeh, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Chemistry, Oncogenesis, Stress and Signaling (COSS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of Gothenburg (GU), Institut National du Cancer (INCa PLBIO) Institut National du Cancer (INCA) France, Fondation pour la Recherche Medicale (FRM) Fondation pour la Recherche Medicale [DEQ20180339169], ERANET, Agence Nationale de la Recherche (ERAAT) French National Research Agency (ANR), EU European Commission [H2020 MSCA ITN-675448, MSCA RISE-734749], Swedish Research Council (VR) Swedish Research Council [2019-3684], Vinnova Seal-of-Excellence programVinnova [2019-02205], Ecole Doctorale 3M, university of Rennes 1, Region BretagneRegion Bretagne, Fondation ARC pour la recherche sur le cancerFondation ARC pour la Recherche sur le Cancer [PDF20191209830], Vinnova Seal-of-Excellence program Vinnova [2019-02205], Region Bretagne Region Bretagne, Fondation ARC pour la recherche sur le cancer Fondation ARC pour la Recherche sur le Cancer [PDF20191209830], European Project: 675448,H2020,H2020-MSCA-ITN-2015,TRAIN-ERS(2015), European Project: 777657,H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge,777657,MSCA-RISE(2018), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CRLCC Eugène Marquis (CRLCC)
Subjects: Protein Folding, RNase P, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, IRE1, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endoribonucleases, Animals, Homeostasis, Humans, [CHIM]Chemical Sciences, Enzyme Inhibitors, Mode of action, Molecular Biology, 030304 developmental biology, 0303 health sciences, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Kinase, Chemistry, Endoplasmic reticulum, structure activity relationship (SAR), Cell Biology, unfolded protein response, Endoplasmic Reticulum Stress, Transmembrane protein, Cell biology, Cytosol, structure-based drug design (SBDD), 030220 oncology & carcinogenesis, Unfolded protein response, Protein folding, ER stress, Signal Transduction
Abstract: International audience; The Unfolded Protein response is an adaptive pathway triggered upon alteration of endoplasmic reticulum (ER) homeostasis. It is transduced by three major ER stress sensors, among which the Inositol Requiring Enzyme 1 (IRE1) is the most evolutionarily conserved. IRE1 is an ER-resident type I transmembrane protein exhibiting an ER luminal domain that senses the protein folding status and a catalytic kinase and RNase cytosolic domain. In recent years, IRE1 has emerged as a relevant therapeutic target in various diseases including degenerative, inflammatory and metabolic pathologies and cancer. As such several drugs altering IRE1 activity were developed that target either catalytic activity and showed some efficacy in preclinical pathological mouse models. In this review, we describe the different drugs identified to target IRE1 activity as well as their mode of action from a structural perspective, thereby identifying common and different modes of action. Based on this information we discuss on how new IRE1-targeting drugs could be developed that outperform the currently available molecules.
Published: 2021
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17. Synthesis of 2,2'-Bipyridines through Catalytic C-C Bond Formations from C-H Bonds

Author: Wided Hagui, Kiruthika Periasamy, Jean-François Soulé, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), CNRS Centre National de la Recherche Scientifique (CNRS) European Commission, Univ. Rennes 1, Rennes Metropole Region Bretagne, Region Bretagne (Boost'Europe) [18003332], Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010405 organic chemistry, Chemistry, Bond, Organic Chemistry, Homogeneous catalysis, Bond formation, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Catalysis, Ligand design, chemistry.chemical_compound, C-H bond activation, N ligands, Synthetic methods, Pyridine, Polymer chemistry, Surface modification, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, Bond cleavage
Abstract: International audience; The present review describes the homogenous catalytic methodologies for the synthesis of 2,2'-bipyridines involving C-C bond formation from C-H bond. There are three main approaches to build well-decorated 2,2'-bipyridines from C-H bond cleavage: i) the formation of C2-C2 ' bond by the dimerization of (activated) pyridines, ii) the C-H bond heteroarylation of activated pyridine, or iii) the late-stage functionalization of (activated) 2,2'-bipyridines including photoredox processes. Besides the scope and limitation of each methodologies, the relevant mechanisms of reaction are also discussed.
Published: 2021
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18. Implementation of film-grain technology within VVC

Author: Erik Reinhard, Wassim Hamidouche, Edouard Francois, Thomas Amestoy, Miloš Radosavljevic, InterDigital R&D France, Institut d'Electronique et de Télécommunications de Rennes (IETR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Supérieure d'Electricité - SUPELEC (FRANCE)-Centre National de la Recherche Scientifique (CNRS), Region Bretagne, France Region Bretagne, Tescher, AG, and Ebrahimi
Subjects: Video production, Computer science, business.industry, Context (language use), Film grain, Lossy compression, versatile video coding, Metadata, [SPI]Engineering Sciences [physics], Computer engineering, Quantization (image processing), business, video compression, VVC, Data compression, Coding (social sciences)
Abstract: International audience; Film grain is often a desirable feature in video production, creating a natural appearance and contributing to the expression of creative intent. Film grain, however, does not compress well with modern video compression standards, such as Versatile Video Coding (VVC) also known as ITU-T H.266 and ISO/IEC 23090-3. Indeed, within various filtering and lossy compression steps, film grain is suppressed without the possibility of recovering it. One option to alleviate this problem is to use lower quantization parameters to better preserve fine details such as film grain. However, this may strongly increase the bitrate. In some scenarios, information on film grain can be communicated as metadata through for instance an SEI message specified by Versatile Supplemental Enhancement Information (VSEI, also known as ITU-T Recommendation H.274 and ISO/IEC 23002-7). Thus, film grain is often modeled and removed prior to compression, and it is then synthesized at the decoder side with the aid of appropriate metadata. In addition, film grain can also be used as a tool to mask coding artifacts introduced by the compression. Different approaches have been studied for film grain modeling. In the context of the novel VVC standard, a frequency filtering solution to parameterize and synthesize film grain can be used. This paper provides an overview of such film grain VVC-compatible technology, including parameterization, signaling and decoder side synthesis. Thus, in this paper, an approach based on the frequency filtering is firstly summarized. Then, a quantitative and qualitative simulations are preformed to show the benefits of film grain parameterization in terms of the bitrate savings for the same perceived quality.
Published: 2021
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19. ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis

Author: Audrey Mouche, Rémy Pedeux, Thierry Guillaudeux, Alice Blondel, Marie Tiercin, Charles Ricordel, Benoit Desrues, Hervé Lena, Agnès Burel, Florence Jouan, Laura Chaillot, Jérôme Archambeau, Chemistry, Oncogenesis, Stress and Signaling (COSS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], CH de Saint-Malo [Broussais], Biosit : biologie, santé, innovation technologique (SFR UMS CNRS 3480 - INSERM 018), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de Microscopie de Rennes (MRic), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), La Ligue Contre le Cancer Ligue nationale contre le cancer, Nuovo-Soldati Fundation research grant, INSERM (Institut National de la Sante et de la Recherche Medicale) Institut National de la Sante et de la Recherche Medicale (Inserm), La Ligue Contre le Cancer (Grand Ouest), Association pour la Recherche sur le Cancer (ARC) Fondation ARC pour la Recherche sur le Cancer, Fondation pour la Recherche Medicale (FMR) Fondation pour la Recherche Medicale [DEQ20180339169], AIS Rennes Metropole Region Bretagne, Biosit, Action Incitative Universite de Rennes 1, Region Bretagne Region Bretagne, FHU Camin (CHU Rennes) doctoral followship, Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: 0301 basic medicine, Mitochondrial ROS, DNA Replication, Cancer Research, Mitochondrial DNA, Tumor suppressor gene, DNA Repair, Transcription, Genetic, DNA repair, [SDV]Life Sciences [q-bio], Receptors, Cytoplasmic and Nuclear, Mitochondrion, Biology, medicine.disease_cause, DNA, Mitochondrial, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Genetics, medicine, Homeostasis, Humans, Molecular Biology, Homeodomain Proteins, Tumor Suppressor Proteins, TFAM, Cell biology, Mitochondria, DNA-Binding Proteins, 030104 developmental biology, Mitochondrial respiratory chain, A549 Cells, 030220 oncology & carcinogenesis, Carcinogenesis
Abstract: International audience; ING2 (Inhibitor of Growth 2) is a tumor suppressor gene that has been implicated in critical biological functions (cell-cycle regulation, replicative senescence, DNA repair and DNA replication), most of which are recognized hallmarks of tumorigenesis occurring in the cell nucleus. As its close homolog ING1 has been recently observed in the mitochondrial compartment, we hypothesized that ING2 could also translocate into the mitochondria and be involved in new biological functions. In the present study, we demonstrate that ING2 is imported in the inner mitochondrial fraction in a redox-sensitive manner in human cells and that this mechanism is modulated by 14-3-3 eta protein expression. Remarkably, ING2 is necessary to maintain mitochondrial ultrastructure integrity without interfering with mitochondrial networks or polarization. We observed an interaction between ING2 and mtDNA under basal conditions. This interaction appears to be mediated by TFAM, a critical regulator of mtDNA integrity. The loss of mitochondrial ING2 does not impair mtDNA repair, replication or transcription but leads to a decrease in mitochondrial ROS production, suggesting a detrimental impact on OXPHOS activity. We finally show using multiple models that ING2 is involved in mitochondrial respiration and that its loss confers a protection against mitochondrial respiratory chain inhibition in vitro. Consequently, we propose a new tumor suppressor role for ING2 protein in the mitochondria as a metabolic shift gatekeeper during tumorigenesis.
Published: 2021
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20. Influential Insider: Wolbachia, an Intracellular Symbiont, Manipulates Bacterial Diversity in Its Insect Host

Author: Ourry, Morgane, Crosland, Agathe, Lopez, Valérie, Derocles, Stéphane A. P., Mougel, Christophe, Cortesero, Anne-Marie, Poinsot, Denis, Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Université de Rennes (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Metaomiques and Ecosystemes Microbiens' Metaprogram of the National Research Institute for Agriculture, Food and Environment (INRAE), Region Bretagne (France) Region Bretagne, INRAE division 'Sante des Plantes et Environnement' [SE 0000282 MP-P10026 EB06], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: QH301-705.5, Erwinia, fungi, food and beverages, biochemical phenomena, metabolism, and nutrition, interactions, bacterial communities, Article, Delia radicum, antagonism, network, [SDE]Environmental Sciences, bacteria, Biology (General), Wolbachia, endosymbiont, cabbage root fly
Abstract: Facultative intracellular symbionts like the α-proteobacteria Wolbachia influence their insect host phenotype but little is known about how much they affect their host microbiota. Here, we quantified the impact of Wolbachia infection on the bacterial community of the cabbage root fly Delia radicum by comparing the microbiota of Wolbachia-free and infected adult flies of both sexes. We used high-throughput DNA sequencing (Illumina MiSeq, 16S rRNA, V5-V7 region) and performed a community and a network analysis. In both sexes, Wolbachia infection significantly decreased the diversity of D. radicum bacterial communities and modified their structure and composition by reducing abundance in some taxa but increasing it in others. Infection by Wolbachia was negatively correlated to 8 bacteria genera (Erwinia was the most impacted), and positively correlated to Providencia and Serratia. We suggest that Wolbachia might antagonize Erwinia for being entomopathogenic (and potentially intracellular), but would favor Providencia and Serratia because they might protect the host against chemical plant defenses. Although they might seem prisoners in a cell, endocellular symbionts can impact the whole microbiota of their host, hence its extended phenotype, which provides them with a way to interact with the outside world.
Published: 2021
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21. Noninvasive Urine-Based Tests to Diagnose or Detect Recurrence of Bladder Cancer

Author: Marine Charpentier, Charly Gutierrez, Thierry Guillaudeux, Grégory Verhoest, Rémy Pedeux, Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Region Bretagne Region Bretagne, European Regional Development Fund European Commission, Rennes Metropole Region Bretagne, VitaDX, University Rennes 1, INSERM Institut National de la Sante et de la Recherche Medicale (Inserm) European Commission, HAL UR1, Admin, and Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV.CAN] Life Sciences [q-bio]/Cancer, liquid biopsy, non-invasive, cytology, bladder cancer, diagnostic, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, urine
Abstract: Simple Summary Bladder cancer (BC) is the tenth most common cancer worldwide, with approximatively 550,000 new cases and 200,000 deaths in 2018. BC is divided into two subgroups: non-muscle invasive bladder cancer, an early stage of the cancer, and muscle invasive bladder cancer, which is more aggressive. The crucial issue today is to be able to detect BC easily and early, with high sensitivity and specificity, in order to treat it sooner, using less invasive methods. Over the past decade, progress has been made to improve detection methods using novel urinary biomarkers. In this review, we discuss the present and future of noninvasive urine tests to diagnose or detect the recurrence of bladder cancer. Abstract Liquid biopsies are increasingly used for the diagnosis and follow-up of cancer patients. Urine is a body fluid that can be used to detect cancers and others diseases. It is noninvasive and easy to collect. To detect Bladder Cancer (BC), cytology is the first assay used. It is an effective way to detect high grade BC but has a high rate of equivocal results, especially for low grade BC. Furthermore, cystoscopy is used to confirm cytology results and to determine cancer status. Cystoscopy is also effective but highly invasive, and not well accepted by patients, especially for BC follow-up. In this review we survey the numerous assays recently developed in order to diagnose BC at an early stage, and to facilitate the follow-up of patients. We discuss their effectiveness, ease of use, and applications. Finally, we discuss assays that, in the future, could improve the diagnosis and management of BC patients.
Published: 2021
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22. Photoinduced Architectural Transformation of Noncovalent Fluorescent Photochromic Organic Nanoparticles as Evidenced by Amplified Fluorescence Photoswitching

Author: Andrea Mulas, Rémi Métivier, Eléna Ishow, Lucie Norel, Thibault Gallavardin, Stéphane Rigaut, Arnaud Brosseau, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), CNRS Centre National de la Recherche Scientifique (CNRS) European Commission, Region Bretagne Region Bretagne, French National Agency French National Research Agency (ANR) [ANR-12-BS07-0010-01], ANR-12-BS07-0010,RuOxLux,Modulation redox de la luminescence à l'aide de complexes organométalliques du ruthénium associés à une unité luminescente(2012), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)
Subjects: fluorescence photoswitching, Fluorophore, Materials science, Coprecipitation, Nanoparticle, 02 engineering and technology, amplification, dye self-sorting, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, photochromism, 01 natural sciences, Fluorescence, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Photochromism, General Energy, chemistry, Organic nanoparticles, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, 0210 nano-technology
Abstract: International audience; Dual nanoparticles endowed with emission photoswitching ability are produced by the flash coprecipitation of fluorophores and photochromes in water in order to investigate the mutual interplay between the self-assembled photoactive units as a function of their respective ratio. Photophysical studies show that high fluorophore/photochrome ratios favor very fast on/off fluorescence photoswitching, while the opposite is true for recovering emission thanks to the strong antenna effects permitted by the spatially confined entities in nanoparticles. Attempts to regenerate the initial state upon visible irradiation reveal unexpected structural transformations, which result from the noncovalent dye self-assemblies. Morphological investigations support phototriggered photochrome clustering within and around the fluorescent core of the dual nanoparticles after a UV-vis cycle or irradiation, causing partitioning of the photoactive units. The photoinduced morphological changes provide attractive prospects in the fabrication of smart drug delivery systems where active material release by external stimuli represents a very dynamic research area.
Published: 2021
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23. DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies

Author: Fabrice Nesslany, Sophie Langouët, Georges Baffet, Vincent Legagneux, Marie Cuvellier, Jennifer Carteret, Arnaud Bruyère, Frédéric Ezan, Sophie Rose, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), ITMO Cancer of AVIESAN (National Alliance for Life Sciences Health), Institut National de la Sante et de la Recherche Medicale (Inserm), University of Rennes 1, PNREST Anses Cancer TMOI AVIESAN [2013/1/166], la Ligue contre le cancer du grand Ouest, Region Bretagne Region Bretagne, SATT Ouest valorisation, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Chard-Hutchinson, Xavier
Subjects: Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Toxicity screening, Pharmacology, Toxicology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, Long-term differentiation, Dimethyl Sulfoxide, Chronic toxicity, 030304 developmental biology, Liver injury, 0303 health sciences, Micronucleus Tests, Chemistry, In vitro toxicology, 3D culture model, Human liver injury, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, General Medicine, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, In vitro, 3. Good health, [SDV] Life Sciences [q-bio], [SDV.TOX] Life Sciences [q-bio]/Toxicology, Liver, 030220 oncology & carcinogenesis, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Toxicity, HepaRG cells, Hepatocytes, Genotoxicity, Micronucleus, Drug metabolism, DNA Damage
Abstract: International audience; The liver is essential in the elimination of environmental and food contaminants. Given the interspecies differences between rodents and humans, the development of relevant in vitro human models is crucial to investigate liver functions and toxicity in cells that better reflect pathophysiological processes. Classically, the differentiation of the hepatic HepaRG cell line requires high concentration of dimethyl sulfoxide (DMSO), which restricts its usefulness for drug-metabolism studies. Herein, we describe undifferentiated HepaRG cells embedded in a collagen matrix in DMSO-free conditions that rapidly organize into polarized hollow spheroids of differentiated hepatocyte-like cells (Hepoid-HepaRG). Our conditions allow concomitant proliferation with high levels of liver-specific functions and xenobiotic metabolism enzymes expression and activities after a few days of culture and for at least 4 weeks. By studying the toxicity of well-known injury-inducing drugs by treating cells with 1- to 100-fold of their plasmatic concentrations, we showed appropriate responses and demonstrate the sensitivity to drugs known to induce various degrees of liver injury. Our results also demonstrated that the model is well suited to estimate cholestasis and steatosis effects of drugs following chronic treatment. Additionally, DNA alterations caused by four genotoxic compounds (Aflatoxin B-1 (AFB(1)), Benzo[a]Pyrene (B[a]P), Cyclophosphamide (CPA) and Methyl methanesulfonate (MMS)) were quantified in a dose-dependent manner by the comet and micronucleus assays. Their genotoxic effects were significantly increased after either an acute 24 h treatment (AFB(1): 1.5-6 mu M, CPA: 2.5-10 mu M, B[a]P: 12.5-50 mu M, MMS: 90-450 mu M) or after a 14-day treatment at much lower concentrations (AFB(1): 0.05-0.2 mu M, CPA: 0.125-0.5 mu M, B[a]P: 0.125-0.5 mu M) representative to human exposure. Altogether, the DMSO-free 3D culture of Hepoid-HepaRG provides highly differentiated and proliferating cells relevant for various toxicological in vitro assays, especially for drug-preclinical studies and environmental chemicals risk assessment.
Published: 2021
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24. Electronic structure, elastic and optical properties of Bi2Te3/Sb(2)Te3 thermoelectric composites in the periodic-superlattice thin films

Author: Jia Fu, Fabrice Bernard, Jiaxuan Huang, Xi'an Shiyou University, Laboratoire de Génie Civil et Génie Mécanique (LGCGM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51905427], National College Students Innovation and Entrepreneurship Training Program [S202010705042], Natural Science Foundation of Shaanxi ProvinceNatural Science Foundation of Shaanxi Province [2020JQ-769], Region Bretagne Region Bretagne, European Union (CPER-FEDER), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)
Subjects: Materials science, Polymers and Plastics, Debye temperatures, Band gap, Superlattice, Homogenized elastic properties, 02 engineering and technology, 01 natural sciences, symbols.namesake, [SPI]Engineering Sciences [physics], Thermal conductivity, 0103 physical sciences, Thermoelectric effect, Materials Chemistry, Thin film, Composite material, Anisotropy, Debye model, Debye, 010302 applied physics, Thermoelectrics, 021001 nanoscience & nanotechnology, Composite Bi2Te3, Mechanics of Materials, Ceramics and Composites, symbols, Sb2Te3 structure, 0210 nano-technology
Abstract: International audience; The outstanding p-type Sb2Te3-based materials such as the Bi2Te3/Sb2Te3 thermoelectric thin films with consideration of anisotropy and synergetic optimization of thermoelectric performance are promising used in practical applications through improving the power factor and reducing the thermal conductivity. Electronic structure, heat capacity and homogenized elastic properties of anisotropic Bi2Te3 and Sb2Te3 crystals are investigated, and then modeled to calculate elastic properties of the composite Bi2Te3/Sb2Te3 thin films. Debye temperature, thermal conductivity and ZT value are especially analysed and found that the Sb-5p/Bi-6p and Te5p at Debye temperatures of 179.29 K and 178.20 K, with the energy gap of 0.207 eV and 0.256 eV in Bi2Te3 and Sb2Te3, which contribute a multiscale modeling scheme from periodic single crystal film to multilayer composite Bi2Te3/Sb2Te3 thin films with higher ZT value, resulting in the significant reduction of band gap and the thermal conductivity due to its superlattice multi-layer structure.
Published: 2021
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25. Ruthenium-catalysed oxidative coupling of vinyl derivatives and application in tandem hydrogenation

Author: Hervé Ruffin, Naba Abuhafez, Rafael Gramage-Doria, Raghu Kamaraj, Christian Bruneau, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), CNRS Centre National de la Recherche Scientifique (CNRS) European Commission, Universite de Rennes 1, ANR-JCJC French National Research Agency (ANR) [ANR-19-CE07-0039], Fondation Rennes 1, Region Bretagne Region Bretagne [1715], ANR-19-CE07-0039,REMOTCAT,Fonctionalisation 'remote' des molecules par catalyse supramoleculaire(2019), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: inorganic chemicals, Ester derivatives, Adipic acid, Tandem, 010405 organic chemistry, Chemistry, chemistry.chemical_element, Oxidative phosphorylation, [CHIM.CATA]Chemical Sciences/Catalysis, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Ruthenium, chemistry.chemical_compound, Reagent, [CHIM]Chemical Sciences, Oxidative coupling of methane
Abstract: International audience; The first ruthenium-catalyzed oxidative homo- and cross-coupling of exclusive vinyl derivatives giving highly valued 1,3-diene building blocks is reported. The catalytic system is based on readily available reagents and it mainly delivers the E,E isomer. This methodology also enables the synthesis of adipic acid ester derivatives in a one-pot fashion after in situ ruthenium-catalyzed hydrogenation.
Published: 2021
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26. Past and current routes to beta-hydroperoxy alcohols: A functional group with high potential in organic synthesis

Author: Vincent Escande, Christophe Darcel, Corentin Bordier, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), DEMETA SAS, Centre National de la Recherche Scientifique (CNRS) Centre National de la Recherche Scientifique (CNRS), French Research Agency (ANR) French National Research Agency (ANR) [17-LCV2-009-01], ANRT agency, Universite de Rennes 1, Demeta S.A.S.com pany, region Bretagne Region Bretagne, ANR-17-LCV2-0009,GREENCARE,Green CAtalysis REnnes(2017), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Allylic rearrangement, Perhydrolysis, 010402 general chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, 4-trioxanes, Drug Discovery, [CHIM]Chemical Sciences, Hydrogen peroxide, High potential, Selective opening, 010405 organic chemistry, Singlet oxygen, Organic Chemistry, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, beta-hydroxy hydroperoxides, chemistry, Functional group, Photooxygenation, Organic synthesis
Abstract: International audience; This review aims to showcase the high potential of beta-hydroperoxy alcohols (HPA) as intermediates in molecular chemistry in both academic and industrial areas. In particular, these are crucial intermediates for the synthesis of 1,2,4-trioxanes, essential motifs in numerous anti-malarial drugs including the lead artemisinin. The aim of this review is to report the main pathways of preparation of HPAs, more particularly highlighting the selective opening of epoxides by hydrogen peroxide solutions or the use of singlet oxygen for the photooxygenation of allylic alcohols. (C) 2021 Elsevier Science. All rights reserved. (C) 2021 Published by Elsevier Ltd.
Published: 2021
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27. Large body size constrains dispersal assembly of communities even across short distances

Author: Bailey, Richard I., Molleman, Freerk, Vasseur, Chloe, Woas, Steffen, Prinzing, Andreas, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institute of Ecology and Earth Sciences, University of Tartu, University of Tartu, Indian Institute of Science Education and Research Pune (IISER Pune), Region Bretagne, Estonian Science Foundation [9215, IUT20-33], European Regional Development Fund (Centre of Excellence FIBIR), Region Bretagne (ACOMB), Region Bretagne (SAD), CNRS (ATIP grant), Government of India (INSPIRE Faculty Award) [DST/INSPIRE/04/2013/000476], Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), and Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Mites, Population Dynamics, lcsh:R, lcsh:Medicine, Article, Trees, Species Specificity, Animals, Body Size, lcsh:Q, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, lcsh:Science, Ecosystem, ComputingMilieux_MISCELLANEOUS
Abstract: Dispersal limitation has been considered to decrease with body size in animals and to be an important factor limiting community assembly on spatially isolated patches. Here we hypothesize that for flightless bark-dwelling oribatid mites dispersal limitation onto young trees might increase with body size (due to a decrease in aerial dispersal capacities), and it might occur even within a spatially contiguous forest canopy. We suppressed dispersal limitation towards branches from young trees by physically connecting them to branches from old trees and analyzed the impacts on community composition, accounting for branch microhabitat variables. Suppression of dispersal limitation increased community evenness and mean body size of mites on branches from young trees. Across all species, large species body-size corresponds to an abundance increase after suppression of dispersal limitation. Consistently, on no-contact control branches, mite body-sizes were larger on branches from old compared to young trees. Our study suggests that colonization/performance trade-offs might affect community assembly even across seemingly contiguous habitats. Overall, a previously underappreciated factor selecting against large body size in flightless canopy-dwelling invertebrates might be that large bodies makes these invertebrates fall faster and disperse less, not more.
Published: 2018
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28. An outbreak in intravenous drug users due to USA300 Latin-American variant community-acquired methicillin-resistant Staphylococcus aureus in France as early as 2007

Author: Mohamed Sassi, Yoann Augagneur, Matthieu Revest, Brice Felden, Pierre-Yves Donnio, Pierre Tattevin, ARN régulateurs bactériens et médecine (BRM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Region Bretagne grant SAD SARS [8254], Region Bretagne grant SAD SARS_2 [9181], and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, [SDV]Life Sciences [q-bio], Clone (cell biology), Microbial Sensitivity Tests, Biology, medicine.disease_cause, DNA sequencing, Disease Outbreaks, Drug Users, 03 medical and health sciences, Medical microbiology, Arginine catabolic mobile element, medicine, Humans, Whole genome sequencing, Phylogenetic tree, Outbreak, General Medicine, Staphylococcal Infections, Virology, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, 3. Good health, Surgery, Community-Acquired Infections, 030104 developmental biology, Infectious Diseases, France
Abstract: International audience; Intravenous drug users are at increased risk of Staphylococcus aureus infections. Most cases are related to clones prevalent in the community. We report an outbreak of community-acquired methicillin-resistant Staphylococcus aureus infections that occurred from 2007 to 2009 in intravenous drug users and their close contacts in Northwestern France. Clinical and molecular investigations suggested that the clones were more similar than those usually isolated in the American continent although none of the patients traveled abroad or had contact with individuals who had traveled to the Americas. Then, a retrospective whole genome sequencing and phylogenetic analyses demonstrated that the strains isolated from the first case belong to the USA300 Latin-American variant clone, based on the absence of arginine catabolic mobile element (ACME), and the presence of copper and mercury resistance mobile element (COMER), a distinctive feature of the South American variant. Our study shows genetic evidence for introduction of this clone as early as 2007 in France. This report also illustrates the importance of genome sequencing to finely characterize and monitor the emergence of unexpected S. aureus clones among high-risk populations, especially when living in promiscuity.
Published: 2017
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29. Rate Constants of the CN plus Toluene Reaction from 15 to 294 K and Interstellar Implications

Author: Divita Gupta, Joseph Messinger, Ilsa R. Cooke, Ian R. Sims, Mitchio Okumura, California Institute of Technology (CALTECH), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), National Science Foundation Graduate Research Fellowship (NSF GRP) program National Science Foundation (NSF), National Science Foundation Graduate Research Opportunities Worldwide (NSF GROW) program, Office of Science and Technology of the Embassy of France in the United States, European Union's Horizon 2020 research and innovation programme under the European Research Council (ERC) [695724-CRESU-CHIRP], American Chemical Society Petroleum Research FundAmerican Chemical Society, European Regional Development FundEuropean Union (EU), European Union's Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant [845165-MIRAGE], Region of Brittany Region Bretagne, Rennes Metropole Region Bretagne, French National Programme \'Physique et Chimie du Milieu Interstellaire (PCMI) of CNRS/INSU, INC/INP - CEA, CNES Centre National D'etudes Spatiales, and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], 010304 chemical physics, Analytical chemistry, Atmospheric temperature range, CRESU, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Toluene, 0104 chemical sciences, Chemical kinetics, Interstellar medium, chemistry.chemical_compound, Benzonitrile, Reaction rate constant, chemistry, 0103 physical sciences, Potential energy surface, Physical and Theoretical Chemistry, Benzene, Molecular physics
Abstract: International audience; CN is known for its fast reactions with hydrocarbons at low temperatures, but relatively few studies have focused on the reactions between CN and aromatic molecules. The recent detection of benzonitrile in the interstellar medium, believed to be produced by the reaction of CN and benzene, has ignited interest in studying these reactions. Her; we report rate constants of the CN + toluene (C7H8) reaction between 15 and 294 K using a CRESU (Cinetique de Reaction en Ecoulement Supersonique Uniforme; reaction kinetics in uniform supersonic flow) apparatus coupled with the pulsed laser photolysis-laser-induced fluorescence (PLP-LIF) technique. We also present the stationary points on the potential energy surface of this reaction to study the available reaction pathways. We find the rate constant does not change over this temperature range, with an average value of (4.1 +/- 0.2) x 10(-10) cm(3) s(-1), which is notably faster than the only previous measurement at 105 K. While the reason for this disagreement is unknown, we discuss the possibility that it is related to enhanced multiphoton effects in the previous work.
Published: 2020
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30. Regorafenib analogues and their ferrocenic counterparts: synthesis and biological evaluation

Author: Dorian Lefebvre, Thierry Roisnel, Thomas Robert, Catherine Le Jossic-Corcos, Danielle Arzur, Stéphane Bach, Myron Wilde, William Erb, Blandine Baratte, Laurent Corcos, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Brest (UBO), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Region Bretagne Region Bretagne, Universite de Rennes 1, CNRS Centre National de la Recherche Scientifique (CNRS), Jonchère, Laurent, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (ABIMS), Fédération de recherche de Roscoff (FR2424), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), and Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Cellular activity, 010405 organic chemistry, Kinase, Squaramide, Biological activity, General Chemistry, Pharmacology, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, chemistry, Regorafenib, [CHIM] Chemical Sciences, Materials Chemistry, [CHIM]Chemical Sciences, Biological evaluation
Abstract: International audience; Approved by the FDA in 2012, regorafenib is one of the last chance treatments for colorectal cancer. While various analogues have already been prepared, ferrocenic derivatives have never been evaluated. In this study, we prepared various ferrocene-containing derivatives of regorafenib and recorded their biological activity in kinase and cellular assays. This led to the identification of a squaramide derivative which shows a good cellular activity and three ferrocene analogues with promising activity in both kinase and cellular assays.
Published: 2020
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31. Generating Skeletal Diversity and Complexity from Boron-Substituted 1,3-Dienes and Enophiles

Author: François, Benjamin, Eberlin, Ludovic, Berrée, Fabienne, Whiting, Andrew, Carboni, Bertrand, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Department of Chemistry [Durham, UK], Durham University, Ministere de l'Education Nationale, de la Recherche et de la Technologie, Centre National de la Recherche Scientifique (CNRS) Centre National de la Recherche Scientifique (CNRS), Region Bretagne Region Bretagne, spectroscopic laboratory of ISCR (Institut des Sciences Chimiques de Rennes), Rennes University, spectroscopic laboratory of Department of Chemistry, Durham University, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Synthetic methods, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Spiro compounds, Pericyclic reactions, Allylboration, Cycloaddition
Abstract: International audience; Boron-substituted 1,3-dienes participate in ene reactions to afford new functionalized synthetic intermediates. After evaluating several enophiles as partners, the resulting products have been engaged in multistep sequences involving first a Diels Alder/allylboration process. A variety of skeletally diverse and complex polycyclic heterocycles were thus synthesized, such as tetrahydro-1H-isoindole-1,3(2H)-diones, eight-membered lactones or tricyclic spiro compounds.
Published: 2020
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32. Design of bis-NHC Ru-complexes featuring diarylmethylene N-substituents for olefin metathesis

Author: Jennifer Morvan, Idriss Curbet, Christophe CrÃ©visy, Thierry Roisnel, Sophie Colombel-Rouen, Marc Mauduit, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), FASO, Region Bretagne (ARED)Region Bretagne [601], Ecole Nationale Superieure de Chimie de Rennes (ENSCR), Centre National de la Recherche Scientifique (CNRS)Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)
Subjects: 010304 chemical physics, Olefin metathesis, 3-dialkylimidazolinium salts, Chemistry, NHC, Organic Chemistry, diaminocarbenes, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, lcsh:QD241-441, lcsh:Organic chemistry, 0103 physical sciences, [CHIM]Chemical Sciences, ruthenium, catalyst
Abstract: International audience; New ruthenium indenylidene complexes containing N-heterocyclic carbene (NHC) ligands were synthesized and evaluated in olefin metathesis. The presence of two symmetrical saturated NHCs featuring N-diarylmethylene fragments (R= H, OMe or F) led to robust ruthenium precatalysts with a good latency. A kinetic study was investigated showing that a thermal stimulus (>60 degrees C) is required to reach an efficient catalytic initiation. Interestingly, a slight electronic effect was observed depending on the presence of an electron-donating or -withdrawing group within the diarylmethylene moiety. These complexes showed good activity at 1 mol% of catalyst loading in selected ring-closing metathesis (RCM) and cross-metathesis (CM) transformations. [GRAPHICS] .
Published: 2019
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33. Dynamics of air–sea CO2 fluxes in the northwestern European shelf based on voluntary observing ship and satellite observations

Author: Marrec, P., Cariou, T., Macé, E., Morin, P., Salt, L. A., Vernet, M., Taylor, B., Paxman, K., Bozec, Y., CHImie Marine (CHIM), Adaptation et diversité en milieu marin (AD2M), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Remote Sensing Group, Plymouth Marine Laboratory, European Project INTERREG IV/MARINEXUS, Conseil General du Finistere (CG29), Region Bretagne (program ARED), Region Bretagne (project CHANNEL), INSU (program LEFE/CYBER), INSU (project CHANNEL), PhD grant from Region Bretagne at UPMC, CHImie Marine ( CHIM ), Adaptation et diversité en milieu marin ( ADMM ), and Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS )
Subjects: [ SDE ] Environmental Sciences, lcsh:Geology, lcsh:QH501-531, [ SDV ] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], lcsh:QH540-549.5, [SDE]Environmental Sciences, lcsh:QE1-996.5, lcsh:Life, lcsh:Ecology
Abstract: From January 2011 to December 2013, we constructed a comprehensive pCO2 data set based on voluntary observing ship (VOS) measurements in the western English Channel (WEC). We subsequently estimated surface pCO2 and air–sea CO2 fluxes in northwestern European continental shelf waters using multiple linear regressions (MLRs) from remotely sensed sea surface temperature (SST), chlorophyll a concentration (Chl a), wind speed (WND), photosynthetically active radiation (PAR) and modeled mixed layer depth (MLD). We developed specific MLRs for the seasonally stratified northern WEC (nWEC) and the permanently well-mixed southern WEC (sWEC) and calculated surface pCO2 with uncertainties of 17 and 16 μatm, respectively. We extrapolated the relationships obtained for the WEC based on the 2011–2013 data set (1) temporally over a decade and (2) spatially in the adjacent Celtic and Irish seas (CS and IS), two regions which exhibit hydrographical and biogeochemical characteristics similar to those of WEC waters. We validated these extrapolations with pCO2 data from the SOCAT and LDEO databases and obtained good agreement between modeled and observed data. On an annual scale, seasonally stratified systems acted as a sink of CO2 from the atmosphere of −0.6 ± 0.3, −0.9 ± 0.3 and −0.5 ± 0.3 mol C m−2 yr−1 in the northern Celtic Sea, southern Celtic sea and nWEC, respectively, whereas permanently well-mixed systems acted as source of CO2 to the atmosphere of 0.2 ± 0.2 and 0.3 ± 0.2 mol C m−2 yr−1 in the sWEC and IS, respectively. Air–sea CO2 fluxes showed important inter-annual variability resulting in significant differences in the intensity and/or direction of annual fluxes. We scaled the mean annual fluxes over these provinces for the last decade and obtained the first annual average uptake of −1.11 ± 0.32 Tg C yr−1 for this part of the northwestern European continental shelf. Our study showed that combining VOS data with satellite observations can be a powerful tool to estimate and extrapolate air–sea CO2 fluxes in sparsely sampled area.
Published: 2015
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34. Dual IRE1 RNase functions dictate glioblastoma development

Author: Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, Véronique Quillien, Aristotelis Chatziioannou, Eric Chevet, Université de Bordeaux (UB), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Theoretical and Physical Chemistry Institute NHRF, National Hellenic Research Foundation, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), National University of Ireland [Galway] (NUI Galway), Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universidad de Santiago de Chile [Santiago] (USACH), Institut National du Cancer (INCa [PLBIO 2017-148, PLBIO 2015-111, INCA_ 7981], La Ligue Contre le Cancer (Comite des Landes, LARGE project), PHC Maimonide, EU H MSCA [ITN-675448, RISE-734749], Region Bretagne 'AAP CRITT sante', French government, Fondation pour la Recherche Medicale, Fondation de France, Region Bretagne, Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), and Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1)
Subjects: Medicine (General), Carcinogenesis, QH426-470, er stress, Chromatin, Epigenetics, Genomics & Functional Genomics, 0302 clinical medicine, glioma, Editorial Note, Tumor Microenvironment, ComputingMilieux_MISCELLANEOUS, Research Articles, 0303 health sciences, Brain Neoplasms, regulated IRE1‐dependent decay, unfolded protein response, Neoplasm Proteins, requiring enzyme 1-alpha, XBP1, Gene Expression Regulation, Neoplastic, endoplasmic reticulum, Phenotype, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Molecular Medicine, regulated IRE1-dependent decay, xbp-1 messenger-rna, Corrigendum, Signal Transduction, Research Article, RNA Splicing, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, [SDV.CAN]Life Sciences [q-bio]/Cancer, IRE1, Protein Serine-Threonine Kinases, Models, Biological, 03 medical and health sciences, R5-920, Cell Line, Tumor, Endoribonucleases, expression, Genetics, Humans, [CHIM]Chemical Sciences, cancer, RNA, Messenger, 030304 developmental biology, pathway, endoplasmic-reticulum, Mutation, Glioblastoma, 030217 neurology & neurosurgery, ire1-alpha, Neuroscience
Abstract: International audience; Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. We previously demonstrated that the ER stress sensor IRE1 alpha (referred to as IRE1) contributes to GBM progression, through XBP1 mRNA splicing and regulated IRE1-dependent decay (RIDD) of RNA. Here, we first demonstrated IRE1 signaling significance to human GBM and defined specific IRE1-dependent gene expression signatures that were confronted to human GBM transcriptomes. This approach allowed us to demonstrate the antagonistic roles of XBP1 mRNA splicing and RIDD on tumor outcomes, mainly through selective remodeling of the tumor stroma. This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression.
Published: 2018
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35. Ambivalent Role of Rotamers in Cyclic(alkyl)(amino)carbene Ruthenium Complexes for Enantioselective Ring-Opening Cross-Metathesis

Author: Jennifer Morvan, François Vermersch, Ziyun Zhang, Thomas Vives, Thierry Roisnel, Christophe Crévisy, Laura Falivene, Luigi Cavallo, Nicolas Vanthuyne, Guy Bertrand, Rodolphe Jazzar, Marc Mauduit, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), UCSD-CNRS Joint Research Chemistry Laboratory (UMI 3555), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of California (UC), King Abdullah University of Science and Technology (KAUST), Università degli Studi di Salerno = University of Salerno (UNISA), Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Region Bretagne (ARED 2018 'Biometa') [ANR-19-CE07-0017 ChiCAAC], Agence Nationale de la Recherche [DE-SC0009376], U.S. Department of Energy, Office of Science, Basic Energy Sciences, Catalysis Science Program, King Abdu l l a h University of Science and Technology (KAUST), 601, and ANR-19-CE07-0017,ChiCAAC,Carbènes alkyl amino cycliques chiraux en catalyse asymétrique(2019)
Subjects: Inorganic Chemistry, Organic Chemistry, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry
Abstract: International audience; The development of highly efficient enantioselective olefin metathesis catalysts is a significant challenge. Using optically pure chiral cyclic (alkyl)(amino)carbene (ChiCAAC) ligands combined with preliminary mechanistic insights and density functional theory (DFT) computations, we show that catalytic performances in this field can be impaired by the formation of rotamers before the enantio-determining step. Using DFT, we also demonstrate that these results can help accelerate the process of ligand discovery by providing faster methods to discriminate potential candidates.
Published: 2023
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36. Structural insights into the binding of bS1 to the ribosome

Author: Gaetano D’Urso, Sophie Chat, Reynald Gillet, Emmanuel Giudice, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Agence Nationale pour la Recherche, JPIAMR, Region Bretagne, CNRS, Rennes University, and ANR-18-JAM2-0005,RIBOTARGET(2018)
Subjects: [SDV]Life Sciences [q-bio], Genetics
Abstract: The multidomain ribosomal protein bS1 is the biggest and the most flexible and dynamic protein in the 30S small subunit. Despite being essential for mRNA recruitment and its primary role in the accommodation of the start codon within the decoding centre, there has not yet been a high-resolution description of its structure. Here, we present a 3D atomic model of OB1 and OB2, bS1’s first two N-terminal domains, bound to an elongation-competent 70S ribosome. Our structure reveals that, as previously reported, bS1 is anchored both by a π-stacking to the 30S subunit and via a salt bridge with the Zn2+ pocket of bS1. These contacts are further stabilized by other interactions with additional residues on OB1. Our model also shows a new conformation of OB2, interacting with the Shine–Dalgarno portion of the mRNA. This study confirms that OB1 plays an anchoring role, but also highlights a novel function for OB2, which is directly involved in the modulation and support of mRNA binding and accommodation on the ribosome.
Published: 2023
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37. Optimized Local Synthetic Conditions Induce Size Reduction and Phase Purification in {[Fe(Htrz)2(trz)](BF4)}n Spin Crossover Particles

Author: Tristan Castel, Anaïs Marchetti, Félix Houard, Nathalie Daro, Mathieu Marchivie, Guillaume Chastanet, Kevin Bernot, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), This work was supported by the University of Bordeaux, the CNRS, the ANR FlowSwitch (2019-CE07-0022-01), and the Region Nouvelle Aquitaine. The Region Bretagne (Boost’ERC RECoord No. 1122), the Institut Universitaire de France (IUF), and the INSA Rennes PPI program., and ANR-19-CE07-0022,FlowSwith,Chimie en flux continu pour la synthèse de particules commutables à température ambiante(2019)
Subjects: Granular materials, Mixtures, Nanoparticles, General Materials Science, Chemical synthesis, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, Condensed Matter Physics, Transmission electron microscopy
Abstract: International audience; The well-known synthesis of the two polymorphs of the {[Fe(Htrz)2(trz)](BF4)}n spin crossover coordination polymer is explored with new template-free methods that allow a control over the local synthetic conditions. A “one-pot” synthesis approach is developed, in which the solid reactants are mixed together before the addition of the solvent, which is expected to generate instantaneous supersaturation conditions favoring the nucleation of particles over their growth. In a second method, the addition of ultrasound pulses promotes the appearance of local “hot spots” that affect the local temperature and allow exploring a different region of the concentration–temperature phase diagram, leading to an increase in the phase purity of the product. These two syntheses are compared to the classical method in which the reactants are first dissolved in separate solutions before being mixed. The use of a one-pot synthesis, with or without ultrasound pulses, induces a downsizing of the particle size by a factor of 500 on their volume. The addition of ultrasound pulses allows moving from a mixture of polymorphs I and II of this compound to the pure phase I. These approaches open the way to more studies on the control over the size or phase purity in such molecular compounds, without the use of any surfactant.
Published: 2023
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38. Hygrothermal transfers through a bio-based multilayered wall: Modeling study of different wall configurations subjected to various climates and indoor cyclic loads

Author: Nicolas Reuge, Florence Collet, Sylvie Pretot, Sophie Moisette, Marjorie Bart, Oliver Style, Andy Shea, Christophe Lanos, Laboratoire de Génie Civil et Génie Mécanique (LGCGM), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Praxis Resilient Buildings, University of Bath [Bath], European project ISOBIO [636835], French region Bretagne Loire, and European Project: 636835,H2020,H2020-EeB-2014,ISOBIO(2015)
Subjects: [SPI]Engineering Sciences [physics], Materials Science(all), Bio-based building materials, local kinetics of sorption, modeling, General Materials Science, Building and Construction, hygrothermal transfer, moisture regulation
Abstract: International audience; The hygrothermal behavior of a bio-based multilayered wall has been studied by numerical simulations. The key point of these research investigations was to properly describe the hygrothermal transfers occurring inside the studied wall solution. In previous work, the case of the wall subjected to a given real climate (Wroughton HIVE demonstrator, UK, Feb 2018) has been investigated. The present work, focused on the moisture regulation capacity of the wall, considers an improved kinetics model of sorption, different layer configurations, one additional climate (Bordeaux, FR, Apr 2008) and the effect of indoor cyclic loads. Compared to the classical approach, the local kinetics approach results in prediction of stronger and steeper hygric dynamics with larger relative humidity variations at small time scales. The study of the different wall configurations allows to determine the best one in terms of moisture damping: the vapor control membrane is advantageously removed provided the OSB3 12 mm layer is replaced by an OSB4 18 mm layer. Moreover, the simulations show that the Moisture Buffer Value characteristic of each material layer is not a sufficient criterion to evaluate hygric performance of the wall; strong hygric interactions occur with the layer's permeability independently of its sorption capacity. Finally, water content hysteresis phenomena are studied and it appears that under usual operating conditions, they can be ignored by adjusting the layers' permeabilities for adequate fits on the Moisture Buffer Value tests.
Published: 2023
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39. Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

Author: Lista, María José, Martins, Rodrigo Prado, Billant, Olivier, Contesse, Marie-Astrid, Findakly, Sarah, Pochard, Pierre, Daskalogianni, Chrysoula, Beauvineau, Claire, Guetta, Corinne, Jamin, Christophe, Teulade-Fichou, Marie-Paule, Fahraeus, Robin, Voisset, Cécile, Blondel, Marc, Michel, Geneviève, Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Chimie, Modélisation et Imagerie pour la Biologie [Orsay], Université Paris-Sud - Paris 11 (UP11)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), La Ligue contre le cancer, La Ligue contre le cancer CSIRGO, CREATE from the Region Bretagne, Fondation ARC, Institut National du cancer (INCa), IBSAM, La Ligue contre le cancer Bretagne, Region Bretagne., Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Lymphocyte B et Auto-immunité (LBAI), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM)
Subjects: [SDV] Life Sciences [q-bio], stomatognathic diseases, maintenance protein EBNA1, viruses, Science, hemic and lymphatic diseases, mRNA, [SDV]Life Sciences [q-bio], otorhinolaryngologic diseases, Epstein-Barr virus, immune evasion
Abstract: International audience; The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GAr) of the EBNA1 protein limits its expression to the minimal level necessary for function while minimizing immune recognition. Here, we identify nucleolin (NCL) as a host factor required for this process via a direct interaction with G-quadruplexes formed in GAr-encoding mRNA sequence. Overexpression of NCL enhances GAr-based inhibition of EBNA1 protein expression, whereas its downregulation relieves the suppression of both expression and antigen presentation. Moreover, the G-quadruplex ligand PhenDC3 prevents NCL binding to EBNA1 mRNA and reverses GAr-mediated repression of EBNA1 expression and antigen presentation. Hence the NCL-EBNA1 mRNA interaction is a relevant therapeutic target to trigger an immune response against EBV-carrying cancers.
Published: 2017
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40. Exploring the mechanical performance and in-planta architecture of secondary hemp fibres

Author: Jérôme Malvestio, Anouck Habrant, Andrew King, David Legland, Nicolas Lenoir, Christophe Baley, David Siniscalco, Johnny Beaugrand, Alain Bourmaud, Institut de Recherche Dupuy de Lôme (IRDL), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique et d'Ingénierie de Bordeaux (I2M), École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Plateforme Aquitaine de Caractérisation des Matériaux (PLACAMAT), Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA), CNRS, Fiabilin program, Oseo, Region Bretagne, Matiere program, Oseo, Region Bretagne, HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), UMS 3626, Université de Bordeaux (UB), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), and HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)
Subjects: Morphology, Materials science, Atomic force microscopy, mu-CT tomography, 030503 health policy & services, Micro tomography, 02 engineering and technology, 021001 nanoscience & nanotechnology, Secondary fibres, Nanoindentation, 03 medical and health sciences, [SPI]Engineering Sciences [physics], Composite material, AFM, 0210 nano-technology, 0305 other medical science, Agronomy and Crop Science, Hemp
Abstract: International audience; Peak-Force Quantitative Nano-Mechanical property mapping (PF-QNM) and Micro Tomography were applied to explore the architecture and nano-mechanical properties of hemp secondary fibres cell walls. After a comparative morphological analysis of both primary and secondary fibres, secondary bundles structure and mechanical properties were investigated. As a first, it was showed that, in spite of important morphological differences, secondary fibres stiffness was the same that primary fibres one; moreover, innovative tomographic images gave an inedited representation of secondary bundles confirming the intrusive development of secondary hemp fibres.
Published: 2017
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41. Global patterns of pelagic dinoflagellate diversity across protist size classes unveiled by metabarcoding

Author: Le Bescot, Noan, Mahé, Frédéric, Audic, Stéphane, Dimier, Céline, Garet, Marie-Jose, Poulain, Julie, Wincker, Patrick, Vargas, Colomban, Siano, Raffaele, Department of ecology, Technische Universität Kaiserslautern (TU Kaiserslautern), Evolution des Protistes et Ecosystèmes Pélagiques (EPEP), Adaptation et diversité en milieu marin (AD2M), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique d'Evry (IG), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE), Dynamiques de l'Environnement Côtier (DYNECO), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Region Bretagne PhD grant, CNRS [GDR3280], Fondation pour la Recherche sur la Biodiversite (FRB), Prince Albert II de Monaco Foundation, ANR (Agence National de la Recherche) [ANR-09-BLAN-0348, ANR-10-INPS-09], French government [ANR-11-BTBR-0008], Veolia Environment Foundation, Region Bretagne, World Courier, Illumina, Cap L'Orient, EDF Foundation Diversiterre, Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie Pélagique (PELAGOS), Dynamiques des Écosystèmes Côtiers (DYNECO), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)
Subjects: [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences
Abstract: International audience; Dinoflagellates (Alveolata) are one of the ecologically most important groups of modern phytoplankton. Their biological complexity makes assessment of their global diversity and community structure difficult. We used massive V9 18S rDNA sequencing from 106 size-fractionated plankton communities collected across the world's surface oceans during the Tara Oceans expedition (2009-2012) to assess patterns of pelagic dinoflagellate diversity and community structuring over global taxonomic and ecological scales. Our data and analyses suggest that dinoflagellate diversity has been largely underestimated, representing overall approximate to 1/2 of protistan rDNA metabarcode richness assigned at 90% to a reference sequence in the world's surface oceans. Dinoflagellate metabarcode diversity and abundance display regular patterns across the global scale, with different order-level taxonomic compositions across organismal size fractions. While the pico to nano-planktonic communities are composed of an extreme diversity of metabarcodes assigned to Gymnodiniales or are simply undetermined, most micro-dinoflagellate metabarcodes relate to the well-referenced Gonyaulacales and Peridiniales orders, and a lower abundance and diversity of essentially symbiotic Peridiniales is unveiled in the meso-plankton. Our analyses could help future development of biogeochemical models of pelagic systems integrating the separation of dinoflagellates into functional groups according to plankton size classes.
Published: 2016
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42. A review on functional nanoarchitectonics nanocomposites based on octahedral metal atom clusters (Nb6, Mo6, Ta6, W6, Re6): inorganic 0D and 2D powders and films

Author: Ngan T. K. Nguyen, Clément Lebastard, Maxence Wilmet, Noée Dumait, Adèle Renaud, Stéphane Cordier, Naoki Ohashi, Tetsuo Uchikoshi, Fabien Grasset, National Institute for Materials Science (NIMS), Laboratory for Innovative Key Materials and Structures (LINK), Saint-Gobain-National Institute of Materials Science-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Saint-Gobain, NIMS, CNRS, Japan Society for the Promotion of Science, Region Bretagne, ANR [CLUSTOP-11-BS08-013-01, CLIMATE-17-CE09-0018], ANR-11-BS08-0013,CLUSTOP,Nanoparticules de silice multifonctionnelles à architectures complexes à base de clusters de métaux de transitions pour des applications en biotechnologies(2011), and ANR-17-CE09-0018,CLIMATE,Matériaux à sélectivité infra-rouge à base de clusters pour économies d'énergie(2017)
Subjects: Solar technology, Coatings, EPD, Thin films, NIR blocker, [CHIM]Chemical Sciences, General Materials Science, Nanoarchitectonics, Octahedral metal atom clusters, Catalysis, Nanocomposites
Abstract: International audience; This review is dedicated to various functional nanoarchitectonic nanocomposites based on molecular octahedral metal atom clusters (Nb-6, Mo-6, Ta-6, W-6, Re-6). Powder and film nanocomposites with two-dimensional, one-dimensional and zero-dimensional morphologies are presented, as well as film matrices from organic polymers to inorganic layered oxides. The high potential and synergetic effects of these nanocomposites for biotechnology applications, photovoltaic, solar control, catalytic, photonic and sensor applications are demonstrated. This review also provides a basic level of understanding how nanocomposites are characterized and processed using different techniques and methods. The main objective of this review would be to provide guiding significance for the design of new high-performance nanocomposites based on transition metal atom clusters.
Published: 2022
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43. The interspecific variations in molecular responses to various doses of heat and cold stress: The case of cereal aphids

Author: Yuan-Jie Li, Chun-Sen Ma, Yi Yan, David Renault, Hervé Colinet, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Hebei University, Chinese Academy of Agricultural Sciences (CAAS), and This project was mainly funded by ARED PhD grant, provided by Region Bretagne (project climPuce COH20023). Parts of the study were supported by the International Research Project (IRP) 'Phenomic Responses of Invertebrates to Changing Environments and Multiple Stress' (PRICES) supported by CNRS and by International Emerging Actions (IEA - CLIMRESIST) also provided by CNRS. Parts of the work were supported by National Natural Science Foundation of China 31620103914, the Fundamental Research Funds of CAAS (Y2017LM10), and Innovation Program of CAAS (CAAS-ZDRW202012).
Subjects: Cereal pests, Molecular chaperones, Physiology, Insect Science, [SDE]Environmental Sciences, Heat and cold shock, hsp genes
Abstract: International audience; Insects are currently subjected to unprecedented thermal stress due to recent increases in the frequency and amplitude of temperature extremes. Understanding molecular responses to thermal stress is critically important to appreciate how species react to thermal stress. Three co-occurring cosmopolitan species are found within the guild of cereal aphids: Sitobion avenae, Ropalosiphum padi and Metopolophium dirhodum. Earlier reports have shown that increasing frequency of temperature extremes causes a shift in dominant species within guilds of cereal aphids by differently altering the population’s growth. We hypothesize that a differential molecular response to stress among species may partially explain these changes. Heat shock proteins (HSPs) are molecular chaperones well known to play an important role in protecting against the adverse effects of thermal stress. However, few studies on molecular chaperones have been conducted in cereal aphids. In this study, we compared the heat and cold tolerance between three aphid species by measuring the median lethal time (Lt50) and examined the expression profiles of seven hsp genes after exposures to comparable thermal injury levels and also after same exposure durations. Results showed that R. padi survived comparatively better at high temperatures than the two other species but was more cold-sensitive. Hsp genes were induced more strongly by heat than cold stress. Hsp70A was the most strongly up-regulated gene in response to both heat and cold stress. R. padi had more heat inducible genes and significantly higher mRNA levels of hsp70A, hsp10, hsp60 and hsp90 than the other two species. Hsps ceased to be expressed at 37 °C in M. dirhodum and S. avenae while expression was maintained in R. padi. In contrast, M. dirhodum was more cold tolerant and had more cold inducible genes than the others. These results confirm species-specific differences in molecular stress responses and suggest that differences in induced expression of hsps may be related to species’ thermal tolerance, thus causing the changes in the relative abundance.
Published: 2023
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44. Interspecific differences in thermal tolerance landscape explain aphid community abundance under climate change

Author: Yuan-Jie Li, Si-Yang Chen, Lisa Bjerregaard Jørgensen, Johannes Overgaard, David Renault, Hervé Colinet, Chun-Sen Ma, Hebei University, Chinese Academy of Agricultural Sciences (CAAS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Aarhus University [Aarhus], and This work was supported by National Natural Science Foundation of China 31620103914, the Fundamental Research Funds of CAAS (Y2017LM10), and Innovation Program of CAAS (CAAS-ZDRW202012). The study was funded by the International Research Project (IRP) 'Phenomic Responses of Invertebrates to Changing Environments and Multiple Stress' (PRICES) supported by InEE-CNRS. This project was supported by ARED PhD grant, provided by Region Bretagne (project climPuce COH20023).
Subjects: Cereal aphids, Physiology, Sitobion avenae, [SDE]Environmental Sciences, Extreme temperature, Metopolophium dirhodum, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, General Agricultural and Biological Sciences, Biochemistry, Thermal death time curve, Developmental Biology, Rhopalosiphum padi
Abstract: A single critical thermal limit is often used to explain and infer the impact of climate change on geographic range and population abundance. However, it has limited application in describing the temporal dynamic and cumulative impacts of extreme temperatures. Here, we used a thermal tolerance landscape approach to address the impacts of extreme thermal events on the survival of co-existing aphid species (Metopolophium dirhodum, Sitobion avenae and Rhopalosiphum padi). Specifically, we built the thermal death time (TDT) models based on detailed survival datasets of three aphid species with three ages across a broad range of stressful high (34–40 °C) and low (−3∼−11 °C) temperatures to compare the interspecific and developmental stage variations in thermal tolerance. Using these TDT parameters, we performed a thermal risk assessment by calculating the potential daily thermal injury accumulation associated with the regional temperature variations in three wheat-growing sites along a latitude gradient. Results showed that M. dirhodum was the most vulnerable to heat but more tolerant to low temperatures than R. padi and S. avenae. R. padi survived better at high temperatures than Sitobion avenae and M. dirhodum but was sensitive to cold. R. padi was estimated to accumulate higher cold injury than the other two species during winter, while M. dirhodum accrued more heat injury during summer. The warmer site had higher risks of heat injury and the cooler site had higher risks of cold injury along a latitude gradient. These results support recent field observations that the proportion of R. padi increases with the increased frequency of heat waves. We also found that young nymphs generally had a lower thermal tolerance than old nymphs or adults. Our results provide a useful dataset and method for modelling and predicting the consequence of climate change on the population dynamics and community structure of small insects.
Published: 2023
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45. Linear Optical and Third-Order Nonlinear Optical Properties of Some Fluorenyl- and Triarylamine-Containing Tetracyanobutadiene Derivatives

Author: Ziemowit Pokladek, Marie Betou, Frédéric Paul, Olivier Mongin, Mireille Blanchard-Desce, Marek Samoc, Yann Trolez, Mark G. Humphrey, Joanna Olesiak-Banska, Nicolas Ripoche, Katarzyna Matczyszyn, Institute of Physical and Theoretical Chemistry, Wroclaw University of Science and Technology, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Australian National University (ANU), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CNRS, 'Region Bretagne' (ARED), Erasmus program, UR1, Region Bretagne, NCN Maestro grant [DEC-2013/10A/ST4/00114], Australian Research Council, Wroclaw Centre for Networking and Supercomputing, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 2-photon absorption, Electronic structure, 010402 general chemistry, Photochemistry, 01 natural sciences, Two-photon absorption, dyes, Catalysis, Photoinduced electron transfer, photoinduced electron-transfer, Molecule, chromophores, [CHIM]Chemical Sciences, molecules, density-functional theory, organic nanodots, excitation cross-sections, complexes, 010405 organic chemistry, Chemistry, Organic Chemistry, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Chromophore, 0104 chemical sciences, Density functional theory, fluorescence, Cyclic voltammetry, Luminescence
Abstract: International audience; The synthesis and characterization of four new tetracyanobutadiene (TCBD) derivatives (1-3 and 2') incorporating 2- or 2,7-fluorenyl and diphenylamino moieties are reported. The electroactivity of 1-3 and 2' was studied by cyclic voltammetry (CV), while the linear optical and (third order) nonlinear optical (NLO) properties were investigated by electronic spectroscopy and Z -scan studies, respectively. All experimental investigations were rationalized by DFT computations, providing an insight into the electronic structure of these derivatives and on their application potential. We show that these derivatives are nonluminescent in solution at ambient temperatures, but become fluorescent in solvent glasses. This finding constitutes an unprecedented observation for TCBD derivatives. Also, we show by Z-scan studies that these derivatives behave as two-photon absorbers in the near-IR range (800-1050 nm). These third-order NLO properties are discussed and compared with those of their alkynyl precursors (4-6), which have been investigated by two-photon excited fluorescence (TPEF).
Published: 2016
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46. The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain

Author: Anis Amara, Pierre Pericard, Isabel Rodríguez-Moldes, Sylvie Mazan, Quentin Rougemont, Agnès Boutet, Claire Rocancourt, Laurent Laguerre, Ronan Lagadec, María Celina Rodicio, Arnaud Menuet, Benoit G. Godard, Hélène Mayeur, Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Department of Cell Biology and Ecology, Faculty of Biology, University of Santiago de Compostela, Écologie et santé des écosystèmes (ESE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Region Bretagne (EVOVERT grant) [049755], Region Bretagne (PEPTISAN grant) [10010133], National Research Agency (ANR-09-BLAN-026201), CNRS, Universite d'Orleans, Universite Pierre et Marie Curie, ANR (ANR-09-BLAN-026201), Region Bretagne, Genoscope, Evry, France, Region Centre, ABiMS FR2424, Universidade de Santiago de Compostela [Spain] (USC ), and Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)
Subjects: Embryo, Nonmammalian, Left-Right Determination Factors, General Physics and Astronomy, Nodal Signaling Ligands, Functional Laterality, Lampetra, Transforming Growth Factor beta, Petromyzon, Zebrafish, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Multidisciplinary, biology, Biologie du développement, Vertebrate, Gene Expression Regulation, Developmental, Lampreys, Anatomy, Development Biology, Biological sciences, Signal Transduction, Genetics, Evolution, Developmental biology, Zoology, Vertebrate Zoology, Nodal Protein, Molecular Sequence Data, General Biochemistry, Genetics and Molecular Biology, Prosencephalon, biology.animal, [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology, Animals, Diencephalon, Homeodomain Proteins, Base Sequence, Zoologie des vertébrés, Scyliorhinus canicula, General Chemistry, biology.organism_classification, Génétique animale, Fibroblast Growth Factors, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Evolutionary biology, Forebrain, Sharks, Animal genetics, NODAL
Abstract: International audience; Left-right asymmetries in the epithalamic region of the brain are widespread across vertebrates, but their magnitude and laterality varies among species. Whether these differences reflect independent origins of forebrain asymmetries or taxa-specific diversifications of an ancient vertebrate feature remains unknown. Here we show that the catshark Scyliorhinus canicula and the lampreys Petromyzon marinus and Lampetra planeri exhibit conserved molecular asymmetries between the left and right developing habenulae. Long-term pharmacological treatments in these species show that nodal signalling is essential to their generation, rather than their directionality as in teleosts. Moreover, in contrast to zebrafish, habenular left-right differences are observed in the absence of overt asymmetry of the adjacent pineal field. These data support an ancient origin of epithalamic asymmetry, and suggest that a nodal-dependent asymmetry programme operated in the forebrain of ancestral vertebrates before evolving into a variable trait in bony fish.
Published: 2015
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47. A Compact Double-Sided FSS Absorbing Wall for Decoupling 5G Antenna Arrays

Author: Faissal Merzaki, Philippe Besnier, Mohamed Himdi, Xavier Castel, Maelle Sergolle, Thierry Levavasseur, Patrick Caldamone, Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), SERIBASE Industrie, French FUI STARCOM Project, European Union through the European Regional Development Fund, Ministry of Higher Education and Research, Region Bretagne, Departements d'Ille-et-Vilaine and des Cotes d'Armor, Saint-Brieuc Armor Agglomeration, through the CPER project 2015-2020 SOPHIE, and Saint-Brieuc Armor Agglomeration, through the CPER project 2015-2020 MATECOM
Subjects: Resonant frequency, fifth generation (5G) antenna array, Antenna decoupling, Impedance, frequency selective surface (FSS) absorber, Frequency selective surfaces, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Absorption, [SPI]Engineering Sciences [physics], 5G mobile communication, Antennas, Antenna arrays, Electrical and Electronic Engineering
Abstract: International audience; The fifth generation (5G) of mobile communications gives birth to the evolution of the base stations. They progressively include arrays of antennas in the sub-6 GHz frequency band worldwide. Moreover, 5G takes advantage of the beamforming capabilities to gain power efficiency and higher throughputs. Within this framework, achieving high decoupling performance between any pairs of antennas and compactness at the same time become a major challenge. The present paper describes an advanced solution based on the interposition of a thin and low-profile absorbing wall operating in the 3.4-3.6 GHz frequency band. The absorption is provided by a frequency selective surface whose elementary pattern size is first optimized. Then, the compact absorbing wall that associates back-to-back pieces of absorber is interposed between elements of an antenna array. Moreover, the fabrication of both antenna array and decoupling device involve lightweight and low-cost composite technology. The results show that such a compact decoupling device achieves excellent decoupling capabilities while keeping up the antenna array performance.
Published: 2022
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48. Extracting turkey coronaviruses from the intestinal lumen of infected turkey embryos yields full genome data with good coverage by NGS

Author: Alexandre Flageul, Céline Courtillon, Chantal Allée, Aurélie Leroux, Yannick Blanchard, Yves Deleforterie, Béatrice Grasland, Paul Alun Brown, Université de Rennes (UR), Laboratoire de Ploufragan-Plouzané-Niort [ANSES], Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut de Sélection Animale - Hendrix genetics company (ISA), Agence National de Securite Sanitaire de l'Alimentation, l'Environnement et du Travail (ANSES), METASTAVA: Standardisation and validation of metagenomics methods for the detection of foodborne zoonoses, antimicrobial resistance and emerging threats. European Joint Programme One Health [773830], Universite Bretagne Loire, Universite de Rennes 1' (UNIR) [180019], Region Bretagne, and European Project: 773830, H2020-SFS-2017-1 ,One Health EJP(2018)
Subjects: enrichment, MESH: Turkeys, Turkeys, Turkey, General Immunology and Microbiology, [SDV]Life Sciences [q-bio], coronavirus, High-Throughput Nucleotide Sequencing, sequencing, Genome, Viral, MESH: Poultry Diseases, Intestines, MESH: Coronavirus, Turkey, Food Animals, in ovo, NGS, Coronavirus, Turkey, Animals, RNA, Viral, Animal Science and Zoology, MESH: RNA, Viral / genetics, Poultry Diseases
Abstract: International audience; Currently, turkey coronaviruses (TCoV) are isolated from homogenized intestines of experimentally infected embryos to ensure a maximum recovery of viral particles from all components of the intestines. However, the process of homogenization also ensures release of a significant amount of cellular RNAs into the sample that hinders downstream viral genome sequencing. This is especially the case for next generation sequencing (NGS) which sequences molecules at random. This characteristic means that the heavily abundant cellular RNA in the sample drowns out the minority viral RNA during the sequencing process and, consequently, very little to no viral genome data are obtained. To address this problem, a method was developed, in which 10 descendent isolates of the European strain of TCoV were recovered uniquely from the intestinal lumen without homogenization of the tissue. For nine out of 10 samples, NGS produced viral RNA reads with good coverage depth over the entire TCoV genomes. This is a much-needed new, simple and cost effective method of isolating TCoV that facilitates downstream NGS of viral RNA and should be considered as an alternative method for isolating other avian enteric coronaviruses in the interest of obtaining full-length genome sequences.
Published: 2022
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49. Mitochondrial transport, partitioning, and quality control at the heart of cell proliferation and fate acquisition

Author: Giulia Bertolin, Rakesh Kumar Sharma, Abderrahman Chafik, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), SAD grant, Region Bretagne, Centre National de la Recherche Scientifique, Fondation ARC pour la Recherche sur le Cancer, and Grand Ouest grant, Ligue Contre le Cancer
Subjects: Physiology, [SDV]Life Sciences [q-bio], Cellular differentiation, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Cell, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Mitochondrion, Biology, Mitochondrial Dynamics, Mitochondria, Heart, Yeasts, Mitophagy, medicine, anatomy_morphology, Animals, Homeostasis, Humans, Cell Lineage, Myocytes, Cardiac, Mitochondrial transport, Cell growth, Biological Transport, Cell Differentiation, dynamics, Cell Biology, Cell cycle, Cell biology, mitochondria, fate acquisition, medicine.anatomical_structure, Phenotype, transport, Energy Metabolism
Abstract: International audience; Mitochondria are essential to cell homeostasis, and alterations in mitochondrial distribution, segregation, and turnover have been linked to complex pathologies such as neurodegenerative diseases and cancer. Understanding how these functions are coordinated in specific cell types is a major challenge to discover how mitochondria globally shape cell functionality. In this review, we first describe how mitochondrial transport and dynamics are regulated throughout the cell cycle in yeast and in mammals. Second, we explore the functional consequences of mitochondrial transport and partitioning on cell proliferation, fate acquisition, and stemness and on the way cells adapt their metabolism. Finally, we focus on how mitochondrial clearance programs represent a further layer of complexity for cell differentiation or in the maintenance of stemness. Defining how mitochondrial transport, dynamics, and clearance are mutually orchestrated in specific cell types may help our understanding of how cells can transition from a physiological to a pathological state.
Published: 2022
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50. Interference with zinc homeostasis and oxidative stress induction as probable mechanisms for cadmium-induced embryo-toxicity in zebrafish

Author: Lina Chouchene, Kaouthar Kessabi, Marie-Madeleine Gueguen, Olivier Kah, Farzad Pakdel, Imed Messaoudi, Université de Monastir - University of Monastir (UM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Ministry of Higher Education and Scientific Research of Tunisia, French Ministry of Ecology, Energy and Sustainable Development [MIXEZ 11-MRES-PNRPE-7-CVS-033], University of Monastir (Tunisia), INSERMInstitut National de la Sante et de la Recherche Medicale (Inserm)European Commission, University of Rennes 1 (France), and Rennes Metropole (France)Region Bretagne
Subjects: [SDV]Life Sciences [q-bio], Health, Toxicology and Mutagenesis, General Medicine, Pollution, Zinc, Larvae, Zinc transporters, Oxidative stress, Animals, Homeostasis, Environmental Chemistry, Metallothionein, Mortality, Zebrafish, Developmental anomalies, Cadmium
Abstract: International audience; The present study was conducted to provide new insights into the mechanisms that may be responsible for cadmium (Cd)-induced toxicity in zebrafish larvae as well as the role of the trace element zinc (Zn) in reversing Cd harmful effects. For this purpose, zebrafish eggs were exposed to Cd or/and Zn for 96 h. The effects on morphological aspect; mortality rate; Cd, Zn, and metallothionein (MT) levels; oxidative stress biomarkers; as well as molecular expression of some genes involved in Zn metabolism (Zn-MT, ZIP10, and ZnT1) and in antioxidant defense system (Cu/Zn-SOD, CAT and GPx) were examined. Our results showed that Cd toxicity was exerted, initially, by an interference with Zn metabolism. Thus, Cd was able to modify the expression of the corresponding genes so as to ensure its intracellular accumulation at the expense of Zn, causing its depletion. An oxidative stress was then generated, representing the second mode of Cd action which resulted in developmental anomalies and subsequently mortality. Interestingly, significant corrections have been noted following Zn supplementation based, essentially, on its ability to interact with the toxic metal. The increases of Zn bioavailability, the improvement of the oxidative status, as well as changes in Zn transporter expression profile are part of the protection mechanisms. The decrease of Cd-induced MTs after Zn supplement, both at the protein and the mRNA level, suggests that the protection provided by Zn is ensured through mechanisms not involving MT expression but which rather depend on the oxidative status.
Published: 2022
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