Author: "Rees I" - Searchworks@Jio Institute Digital Library Search Results

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193 results on '"Rees I"'

1. Searches for Time Dependent Neutrino Sources with IceCube Data from 2008 to 2012

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Baker, M., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dumm, J. P., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., In, S., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tamburro, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: In this paper searches for flaring astrophysical neutrino sources and sources with periodic emission with the IceCube neutrino telescope are presented. In contrast to time integrated searches, where steady emission is assumed, the analyses presented here look for a time dependent signal of neutrinos using the information from the neutrino arrival times to enhance the discovery potential. A search was performed for correlations between neutrino arrival times and directions as well as neutrino emission following time dependent lightcurves, sporadic emission or periodicities of candidate sources. These include active galactic nuclei, soft $\gamma$-ray repeaters, supernova remnants hosting pulsars, micro-quasars and X-ray binaries. The work presented here updates and extends previously published results to a longer period that covers four years of data from 2008 April 5 to 2012 May 16 including the first year of operation of the completed 86-string detector. The analyses did not find any significant time dependent point sources of neutrinos and the results were used to set upper limits on the neutrino flux from source candidates.
Published: 2015
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2. Flavor Ratio of Astrophysical Neutrinos above 35 TeV in IceCube

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dumm, J. P., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tamburro, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract: A diffuse flux of astrophysical neutrinos above $100\,\mathrm{TeV}$ has been observed at the IceCube Neutrino Observatory. Here we extend this analysis to probe the astrophysical flux down to $35\,\mathrm{TeV}$ and analyze its flavor composition by classifying events as showers or tracks. Taking advantage of lower atmospheric backgrounds for shower-like events, we obtain a shower-biased sample containing 129 showers and 8 tracks collected in three years from 2010 to 2013. We demonstrate consistency with the $(f_e:f_{\mu}:f_\tau)_\oplus\approx(1:1:1)_\oplus$ flavor ratio at Earth commonly expected from the averaged oscillations of neutrinos produced by pion decay in distant astrophysical sources. Limits are placed on non-standard flavor compositions that cannot be produced by averaged neutrino oscillations but could arise in exotic physics scenarios. A maximally track-like composition of $(0:1:0)_\oplus$ is excluded at $3.3\sigma$, and a purely shower-like composition of $(1:0:0)_\oplus$ is excluded at $2.3\sigma$., Comment: 8 pages, 3 figures. Submitted to PRL
Published: 2015
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3. Search for Prompt Neutrino Emission from Gamma-Ray Bursts with IceCube

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present constraints derived from a search of four years of IceCube data for a prompt neutrino flux from gamma-ray bursts (GRBs). A single low-significance neutrino, compatible with the atmospheric neutrino background, was found in coincidence with one of the 506 observed bursts. Although GRBs have been proposed as candidate sources for ultra-high energy cosmic rays, our limits on the neutrino flux disfavor much of the parameter space for the latest models. We also find that no more than $\sim1\%$ of the recently observed astrophysical neutrino flux consists of prompt emission from GRBs that are potentially observable by existing satellites., Comment: 15 pages, 3 figures
Published: 2014
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4. IceCube-Gen2: A Vision for the Future of Neutrino Astronomy in Antarctica

Author: Collaboration, IceCube-Gen2, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Anton, G., Arguelles, C., Arlen, T. C., Auffenberg, J., Axani, S., Bai, X., Bartos, I., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Collin, G. H., Conrad, J. M., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., andaz-Vélez, J. C. Dí, Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, S., Evans, J. J., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Haugen, J., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jlelati, O., Jones, B. J. P., Jurkovic, M., Kalekin, O., Kappes, A., Karg, T., Karle, A., Katori, T., Katz, U. F., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krauss, C. B., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., LoSecco, J., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Marka, S., Marka, Z., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Moore, R. W., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Pinfold, J. L., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Sandstrom, P., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shaevitz, M. H., Shanidze, R., Smith, M. W. E., Soldin, D., Söldner-Rembold, S., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., andl, A. Stöß, Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Taketa, A., Tamburro, A., Tanaka, H. K. M., Tepe, A., Ter-Antonyan, S., Terliuk, A., Teš, G., andić, Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Wren, S., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: The recent observation by the IceCube neutrino observatory of an astrophysical flux of neutrinos represents the "first light" in the nascent field of neutrino astronomy. The observed diffuse neutrino flux seems to suggest a much larger level of hadronic activity in the non-thermal universe than previously thought and suggests a rich discovery potential for a larger neutrino observatory. This document presents a vision for an substantial expansion of the current IceCube detector, IceCube-Gen2, including the aim of instrumenting a $10\,\mathrm{km}^3$ volume of clear glacial ice at the South Pole to deliver substantial increases in the astrophysical neutrino sample for all flavors. A detector of this size would have a rich physics program with the goal to resolve the sources of these astrophysical neutrinos, discover GZK neutrinos, and be a leading observatory in future multi-messenger astronomy programs., Comment: 20 pages, 12 figures. Address correspondence to: E. Blaufuss, F. Halzen, C. Kopper (Changed to add one missing author, no other changes from initial version.)
Published: 2014

5. SCHOOL MUSIC ROOMS - DESIGNING BEYOND BB93

Author: JAMES, A, primary, THOMPSON, A, additional, and REES, I, additional
Published: 2023
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6. Determining neutrino oscillation parameters from atmospheric muon neutrino disappearance with three years of IceCube DeepCore data

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Brunner, J., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: We present a measurement of neutrino oscillations via atmospheric muon neutrino disappearance with three years of data of the completed IceCube neutrino detector. DeepCore, a region of denser instrumentation, enables the detection and reconstruction of atmospheric muon neutrinos between 10 GeV and 100 GeV, where a strong disappearance signal is expected. The detector volume surrounding DeepCore is used as a veto region to suppress the atmospheric muon background. Neutrino events are selected where the detected Cherenkov photons of the secondary particles minimally scatter, and the neutrino energy and arrival direction are reconstructed. Both variables are used to obtain the neutrino oscillation parameters from the data, with the best fit given by $\Delta m^2_{32}=2.72^{+0.19}_{-0.20}\times 10^{-3}\,\mathrm{eV}^2$ and $\sin^2\theta_{23} = 0.53^{+0.09}_{-0.12}$ (normal mass hierarchy assumed). The results are compatible and comparable in precision to those of dedicated oscillation experiments., Comment: 10 pages, 7 figures
Published: 2014
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7. Atmospheric and Astrophysical Neutrinos above 1 TeV Interacting in IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The IceCube Neutrino Observatory was designed primarily to search for high-energy (TeV--PeV) neutrinos produced in distant astrophysical objects. A search for $\gtrsim 100$~TeV neutrinos interacting inside the instrumented volume has recently provided evidence for an isotropic flux of such neutrinos. At lower energies, IceCube collects large numbers of neutrinos from the weak decays of mesons in cosmic-ray air showers. Here we present the results of a search for neutrino interactions inside IceCube's instrumented volume between 1~TeV and 1~PeV in 641 days of data taken from 2010--2012, lowering the energy threshold for neutrinos from the southern sky below 10 TeV for the first time, far below the threshold of the previous high-energy analysis. Astrophysical neutrinos remain the dominant component in the southern sky down to 10 TeV. From these data we derive new constraints on the diffuse astrophysical neutrino spectrum, $\Phi_{\nu} = 2.06^{+0.4}_{-0.3} \times 10^{-18} \left({E_{\nu}}/{10^5 \,\, \rm{GeV}} \right)^{-2.46 \pm 0.12} {\rm {GeV^{-1} \, cm^{-2} \, sr^{-1} \, s^{-1}} } $, as well as the strongest upper limit yet on the flux of neutrinos from charmed-meson decay in the atmosphere, 1.52 times the benchmark theoretical prediction used in previous IceCube results at 90\% confidence., Comment: 18 pages, 12 figures
Published: 2014
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8. Development of a General Analysis and Unfolding Scheme and its Application to Measure the Energy Spectrum of Atmospheric Neutrinos with IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., deAndré, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., and Morik, K.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the development and application of a generic analysis scheme for the measurement of neutrino spectra with the IceCube detector. This scheme is based on regularized unfolding, preceded by an event selection which uses a Minimum Redundancy Maximum Relevance algorithm to select the relevant variables and a Random Forest for the classification of events. The analysis has been developed using IceCube data from the 59-string configuration of the detector. 27,771 neutrino candidates were detected in 346 days of livetime. A rejection of 99.9999% of the atmospheric muon background is achieved. The energy spectrum of the atmospheric neutrino flux is obtained using the TRUEE unfolding program. The unfolded spectrum of atmospheric muon neutrinos covers an energy range from 100 GeV to 1 PeV. Compared to the previous measurement using the detector in the 40-string configuration, the analysis presented here, extends the upper end of the atmospheric neutrino spectrum by more than a factor of two, reaching an energy region that has not been previously accessed by spectral measurements., Comment: Version 3: includes referee comments from EPJC
Published: 2014
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9. Searches for small-scale anisotropies from neutrino point sources with three years of IceCube data

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, J.2
Abstract: Recently, IceCube found evidence for a diffuse signal of astrophysical neutrinos in an energy range of $60\,\mathrm{TeV}$ to the $\mathrm{PeV}$-scale. The origin of those events, being a key to understanding the origin of cosmic rays, is still an unsolved question. So far, analyses have not succeeded to resolve the diffuse signal into point-like sources. Searches including a maximum-likelihood-ratio test, based on the reconstructed directions and energies of the detected down- and up-going neutrino candidates, were also performed on IceCube data leading to the exclusion of bright point sources. In this paper, we present two methods to search for faint neutrino point sources in three years of IceCube data, taken between 2008 and 2011. The first method is an autocorrelation test, applied separately to the northern and southern sky. The second method is a multipole analysis, which expands the measured data in the northern hemisphere into spherical harmonics and uses the resulting expansion coefficients to separate signal from background. With both methods, the results are consistent with the background expectation with a slightly more sparse spatial distribution, corresponding to an underfluctuation. Depending on the assumed number of sources, the resulting upper limit on the flux per source in the northern hemisphere for an $E^{-2}$ energy spectrum ranges from $1.5 \cdot 10^{-8}\,\mathrm{GeV}/(\mathrm{cm}^2 \mathrm{s})$, in the case of one assumed source, to $4 \cdot 10^{-10} \,\mathrm{GeV}/(\mathrm{cm}^2 \mathrm{s})$, in the case of $3500$ assumed sources., Comment: 35 pages, 16 figures, 1 table
Published: 2014
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10. Multimessenger Search for Sources of Gravitational Waves and High-Energy Neutrinos: Results for Initial LIGO-Virgo and IceCube

Author: The IceCube Collaboration, The LIGO Scientific Collaboration, The Virgo Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Collaboration, M. Zoll. The LIGO Scientific, Collaboration, the Virgo, Aasi, J., Abbott, B. P., Abbott, R., Abbott, T., Abernathy, M. R., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Affeldt, C., Agathos, M., Aggarwal, N., Aguiar, O. D., Ajith, P., Alemic, A., Allen, B., Allocca, A., Amariutei, D., Andersen, M., Anderson, R. A., Anderson, S. B., Anderson, W. G., Arai, K., Araya, M. C., Arceneaux, C., Areeda, J. S., Ast, S., Aston, S. 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W., Coulon, J. -P., Countryman, S., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Croce, R. P., Crowder, S. G., Cumming, A., Cunningham, L., Cuoco, E., Cutler, C., Dahl, K., Canton, T. Dal, Damjanic, M., Danilishin, S. L., D'Antonio, S., Danzmann, K., Dattilo, V., Daveloza, H., Davier, M., Davies, G. S., Daw, E. J., Day, R., Dayanga, T., DeBra, D., Debreczeni, G., Degallaix, J., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dereli, H., Dergachev, V., De Rosa, R., DeRosa, R. T., DeSalvo, R., Dhurandhar, S., Díaz, M., Dickson, J., Di Fiore, L., Di Lieto, A., Di Palma, I., Di Virgilio, A., Dolique, V., Dominguez, E., Donovan, F., Dooley, K. L., Doravari, S., Douglas, R., Downes, T. P., Drago, M., Drever, R. W. P., Driggers, J. C., Du, Z., Ducrot, M., Dwyer, S., Eberle, T., Edo, T., Edwards, M., Effler, A., Eggenstein, H. -B., Ehrens, P., Eichholz, J., Eikenberry, S. 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J., Gushwa, K., Gustafson, E. K., Gustafson, R., Ha, J., Hall, E. D., Hamilton, W., Hammer, D., Hammond, G., Hanke, M., Hanks, J., Hanna, C., Hannam, M. D., Hanson, J., Harms, J., Harry, G. M., Harry, I. W., Harstad, E. D., Hart, M., Hartman, M. T., Haster, C. -J., Haughian, K., Heidmann, A., Heintze, M., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Heptonstall, A. W., Heurs, M., Hewitson, M., Hild, S., Hoak, D., Hodge, K. A., Hofman, D., Holt, K., Hopkins, P., Horrom, T., Hoske, D., Hosken, D. J., Hough, J., Howell, E. J., Hu, Y., Huerta, E., Hughey, B., Husa, S., Huttner, S. H., Huynh, M., Huynh-Dinh, T., Idrisy, A., Ingram, D. R., Inta, R., Islas, G., Isogai, T., Ivanov, A., Iyer, B. R., Izumi, K., Jacobson, M., Jang, H., Jaranowski, P., Ji, Y., Jiménez-Forteza, F., Johnson, W. W., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., K, Haris, Kalmus, P., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J. B., Karlen, J., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, H., Kaufer, S., Kaur, T., Kawabe, K., Kawazoe, F., Kéfélian, F., Keiser, G. M., Keitel, D., Kelley, D. B., Kells, W., Keppel, D. G., Khalaidovski, A., Khalili, F. Y., Khazanov, E. A., Kim, C., Kim, K., Kim, N. G., Kim, N., Kim, S., Kim, Y. -M., King, E. J., King, P. J., Kinzel, D. L., Kissel, J. S., Klimenko, S., Kline, J., Koehlenbeck, S., Kokeyama, K., Kondrashov, V., Koranda, S., Korth, W. Z., Kowalska, I., Kozak, D. B., Kringel, V., Królak, A., Kuehn, G., Kumar, A., Kumar, D. Nanda, Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lam, P. K., Landry, M., Lantz, B., Larson, S., Lasky, P. D., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Lee, J., Lee, P. J., Leonardi, M., Leong, J. R., Roux, A. Le, Leroy, N., Letendre, N., Levin, Y., Levine, B., Lewis, J., Li, T. G. F., Libbrecht, K., Libson, A., Lin, A. C., Littenberg, T. B., Lockerbie, N. A., Lockett, V., Lodhia, D., Loew, K., Logue, J., Lombardi, A. L., Lopez, E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J., Lubinski, M. J., Lück, H., Lundgren, A. P., Ma, Y., Macdonald, E. P., MacDonald, T., Machenschalk, B., MacInnis, M., Macleod, D. M., Magaña-Sandoval, F., Magee, R., Mageswaran, M., Maglione, C., Mailand, K., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Manca, G. M., Mandel, I., Mandic, V., Mangano, V., Mangini, N. M., Mansell, G., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A., Maros, E., Marque, J., Martelli, F., Martin, I. W., Martin, R. M., Martinelli, L., Martynov, D., Marx, J. N., Mason, K., Masserot, A., Massinger, T. J., Matichard, F., Matone, L., Mavalvala, N., May, G., Mazumder, N., Mazzolo, G., McCarthy, R., McClelland, D. E., McGuire, S. C., McIntyre, G., McIver, J., McLin, K., Meacher, D., Meadors, G. D., Mehmet, M., Meidam, J., Meinders, M., Melatos, A., Mendell, G., Mercer, R. A., Meshkov, S., Messenger, C., Meyer, M. S., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Mikhailov, E. E., Milano, L., Minenkov, Y., Mingarelli, C. M. F., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moe, B., Moggi, A., Mohan, M., Mohapatra, S. R. P., Moraru, D., Moreno, G., Morgado, N., Morriss, S. R., Mossavi, K., Mours, B., Mow-Lowry, C. M., Mueller, C. L., Mueller, G., Mukherjee, S., Mullavey, A., Munch, J., Murphy, D., Murray, P. G., Mytidis, A., Nagy, M. F., Nardecchia, I., Naticchioni, L., Nayak, R. K., Necula, V., Nelemans, G., Neri, I., Neri, M., Newton, G., Nguyen, T., Nielsen, A. B., Nissanke, S., Nitz, A. H., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Ochsner, E., O'Dell, J., Oelker, E., Oh, J. J., Oh, S. H., Ohme, F., Omar, S., Oppermann, P., Oram, R., O'Reilly, B., Ortega, W., O'Shaughnessy, R., Osthelder, C., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Padilla, C., Pai, A., Palashov, O., Palomba, C., Pan, H., Pan, Y., Pankow, C., Paoletti, F., Papa, M. A., Paris, H., Pasqualetti, A., Passaquieti, R., Passuello, D., Pedraza, M., Pele, A., Penn, S., Perreca, A., Phelps, M., Pichot, M., Pickenpack, M., Piergiovanni, F., Pierro, V., Pinard, L., Pinto, I. M., Pitkin, M., Poeld, J., Poggiani, R., Poteomkin, A., Powell, J., Prasad, J., Predoi, V., Premachandra, S., Prestegard, T., Price, L. R., Prijatelj, M., Privitera, S., Prodi, G. A., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qin, J., Quetschke, V., Quintero, E., Quitzow-James, R., Raab, F. J., Rabeling, D. S., Rácz, I., Radkins, H., Raffai, P., Raja, S., Rajalakshmi, G., Rakhmanov, M., Ramet, C., Ramirez, K., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Recchia, S., Reed, C. M., Regimbau, T., Reid, S., Reitze, D. H., Reula, O., Rhoades, E., Ricci, F., Riesen, R., Riles, K., Robertson, N. A., Robinet, F., Rocchi, A., Roddy, S. B., Rolland, L., Rollins, J. G., Romano, R., Romanov, G., Romie, J. H., Rosińska, D., Rowan, S., Rüdiger, A., Ruggi, P., Ryan, K., Salemi, F., Sammut, L., Sandberg, V., Sanders, J. R., Sankar, S., Sannibale, V., Santiago-Prieto, I., Saracco, E., Sassolas, B., Sathyaprakash, B. S., Saulson, P. R., Savage, R., Scheuer, J., Schilling, R., Schilman, M., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schreiber, E., Schuette, D., Schutz, B. F., Scott, J., Scott, S. M., Sellers, D., Sengupta, A. S., Sentenac, D., Sequino, V., Sergeev, A., Shaddock, D. A., Shah, S., Shahriar, M. S., Shaltev, M., Shao, Z., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sidery, T. L., Siellez, K., Siemens, X., Sigg, D., Simakov, D., Singer, A., Singer, L., Singh, R., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., Smith, J. R., Smith, M. R., Smith, R. J. E., Smith-Lefebvre, N. D., Son, E. J., Sorazu, B., Souradeep, T., Staley, A., Stebbins, J., Steinke, M., Steinlechner, J., Steinlechner, S., Stephens, B. C., Steplewski, S., Stevenson, S., Stone, R., Stops, D., Strain, K. A., Straniero, N., Strigin, S., Sturani, R., Stuver, A. L., Summerscales, T. Z., Susmithan, S., Sutton, P. J., Swinkels, B., Tacca, M., Talukder, D., Tanner, D. B., Tao, J., Tarabrin, S. P., Taylor, R., Tellez, G., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thorne, K. A., Thorne, K. S., Thrane, E., Tiwari, V., Tokmakov, K. V., Tomlinson, C., Tonelli, M., Torres, C. V., Torrie, C. I., Travasso, F., Traylor, G., Tse, M., Tshilumba, D., Tuennermann, H., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., Vallisneri, M., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, van der Sluys, M. V., van Heijningen, J., van Veggel, A. A., Vass, S., Vasúth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Verkindt, D., Vetrano, F., Viceré, A., Vincent-Finley, R., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vousden, W. D., Vyachanin, S. P., Wade, A. R., Wade, L., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, M., Wang, X., Ward, R. L., Was, M., Weaver, B., Wei, L. -W., Weinert, M., Weinstein, A. J., Weiss, R., Welborn, T., Wen, L., Wessels, P., West, M., Westphal, T., Wette, K., Whelan, J. T., White, D. J., Whiting, B. F., Wiesner, K., Wilkinson, C., Williams, K., Williams, L., Williams, R., Williams, T. D., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M., Winkler, W., Wipf, C. C., Wiseman, A. G., Wittel, H., Woan, G., Wolovick, N., Worden, J., Wu, Y., Yablon, J., Yakushin, I., Yam, W., Yamamoto, H., Yancey, C. C., Yang, H., Yvert, M., Zadrożny, A., Zanolin, M., Zendri, J. -P., Zhang, Fan, Zhang, L., Zhao, C., Zhu, H., Zhu, X. J., Zucker, M. E., Zuraw, S., and Zweizig, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report the results of a multimessenger search for coincident signals from the LIGO and Virgo gravitational-wave observatories and the partially completed IceCube high-energy neutrino detector, including periods of joint operation between 2007-2010. These include parts of the 2005-2007 run and the 2009-2010 run for LIGO-Virgo, and IceCube's observation periods with 22, 59 and 79 strings. We find no significant coincident events, and use the search results to derive upper limits on the rate of joint sources for a range of source emission parameters. For the optimistic assumption of gravitational-wave emission energy of $10^{-2}$\,M$_\odot$c$^2$ at $\sim 150$\,Hz with $\sim 60$\,ms duration, and high-energy neutrino emission of $10^{51}$\,erg comparable to the isotropic gamma-ray energy of gamma-ray bursts, we limit the source rate below $1.6 \times 10^{-2}$\,Mpc$^{-3}$yr$^{-1}$. We also examine how combining information from gravitational waves and neutrinos will aid discovery in the advanced gravitational-wave detector era.
Published: 2014
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11. Multipole analysis of IceCube data to search for dark matter accumulated in the Galactic halo

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: Dark matter which is bound in the Galactic halo might self-annihilate and produce a flux of stable final state particles, e.g. high energy neutrinos. These neutrinos can be detected with IceCube, a cubic-kilometer sized Cherenkov detector. Given IceCube's large field of view, a characteristic anisotropy of the additional neutrino flux is expected. In this paper we describe a multipole method to search for such a large-scale anisotropy in IceCube data. This method uses the expansion coefficients of a multipole expansion of neutrino arrival directions and incorporates signal-specific weights for each expansion coefficient. We apply the technique to a high-purity muon neutrino sample from the Northern Hemisphere. The final result is compatible with the null-hypothesis. As no signal was observed, we present limits on the self-annihilation cross-section averaged over the relative velocity distribution $<\sigma v>$ down to $1.9\cdot 10^{-23}\,\mathrm{cm}^3\mathrm{s}^{-1}$ for a dark matter particle mass of $700\,\mathrm{GeV}$ to $1000\,\mathrm{GeV}$ and direct annihilation into $\nu\bar{\nu}$. The resulting exclusion limits come close to exclusion limits from $\gamma$-ray experiments, that focus on the outer Galactic halo, for high dark matter masses of a few TeV and hard annihilation channels., Comment: 17 pages, 18 figures, 5 tables
Published: 2014
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12. Searches for Extended and Point-like Neutrino Sources with Four Years of IceCube Data

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present results on searches for point-like sources of neutrinos using four years of IceCube data, including the first year of data from the completed 86-string detector. The total livetime of the combined dataset is 1,373 days. For an E$^{-2}$ spectrum the median sensitivity at 90\% C.L. is $\sim 10^{-12}$ TeV$^{-1}$cm$^{-2}$s$^{-1}$ for energies between 1 TeV$-$1 PeV in the northern sky and $\sim 10^{-11}$ TeV$^{-1}$cm$^{-2}$s$^{-1}$ for energies between 100 TeV $-$ 100 PeV in the southern sky. The sensitivity has improved from both the additional year of data and the introduction of improved reconstructions compared to previous publications. In addition, we present the first results from an all-sky search for extended sources of neutrinos. We update results of searches for neutrino emission from stacked catalogs of sources, and test five new catalogs; two of Galactic supernova remnants and three of active galactic nuclei. In all cases, the data are compatible with the background-only hypothesis, and upper limits on the flux of muon neutrinos are reported for the sources considered., Comment: 36 pages, 15 figures. Submitted to the Astrophysical Journal
Published: 2014
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13. Observation of High-Energy Astrophysical Neutrinos in Three Years of IceCube Data

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract: A search for high-energy neutrinos interacting within the IceCube detector between 2010 and 2012 provided the first evidence for a high-energy neutrino flux of extraterrestrial origin. Results from an analysis using the same methods with a third year (2012-2013) of data from the complete IceCube detector are consistent with the previously reported astrophysical flux in the 100 TeV - PeV range at the level of $10^{-8}\, \mathrm{GeV}\, \mathrm{cm}^{-2}\, \mathrm{s}^{-1}\, \mathrm{sr}^{-1}$ per flavor and reject a purely atmospheric explanation for the combined 3-year data at $5.7 \sigma$. The data are consistent with expectations for equal fluxes of all three neutrino flavors and with isotropic arrival directions, suggesting either numerous or spatially extended sources. The three-year dataset, with a livetime of 988 days, contains a total of 37 neutrino candidate events with deposited energies ranging from 30 to 2000 TeV. The 2000 TeV event is the highest-energy neutrino interaction ever observed., Comment: 8 pages, 5 figures. Accepted by PRL. The event catalog, event displays, and other data tables are included after the final page of the article. Changed from the initial submission to reflect referee comments, expanding the section on atmospheric backgrounds, and fixes offsets of up to 0.9 seconds in reported event times. Address correspondence to: J. Feintzeig, C. Kopper, N. Whitehorn
Published: 2014
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14. Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls

Author: Murillo Perez, C, Fisher, H, Hiu, S, Kareithi, D, Adekunle, F, Mayne, T, Malecha, E, Ness, E, van der Meer, A, Lammers, W, Trivedi, P, Battezzati, P, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Pares, A, Londono, M, Invernizzi, P, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Gulamhusein, A, Janssen, H, Smith, R, Flack, S, Mulcahy, V, Trauner, M, Bowlus, C, Lindor, K, Corpechot, C, Jones, D, Mells, G, Hirschfield, G, Wason, J, Hansen, B, Sturgess, R, Healey, C, Gunasekera, A, Kallis, Y, Wright, G, Mathialahan, T, Evans, R, Gasem, J, Ramanaden, D, Ward, E, Bhalme, M, Southern, P, Maggs, J, Yousif, M, Srivastava, B, Foxton, M, Collins, C, Prasad, Y, Porras-Perez, F, Yapp, T, Patel, M, Ede, R, Carte, M, Koss, K, Sattianayagam, P, Grimley, C, Tidbury, J, Mansour, D, Beckley, M, Hollywood, C, Ramag, J, Gordon, H, Ridpath, J, Grover, B, Abouda, G, Rees, I, Narain, M, Salam, I, Banim, P, Das, D, Matthews, H, Mohammed, F, Jones, R, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Hutchinson, J, Gupta, P, Shah, A, Saha, S, Pollock, K, Barclay, S, Mcdonald, N, Rushbrook, S, Przemioslo, R, Millar, A, Mitchell, S, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Cramp, M, Aspinal, R, Booth, J, Williams, E, Hussaini, H, Christie, J, Chaudhry, T, Mann, S, Ala, A, Maltby, J, Corbett, C, Singhal, S, Hoeroldt, B, Butterworth, J, Douglas, A, Sinha, R, Panter, S, Shearman, J, Bray, G, Roberts, M, Forton, D, Taylor, N, Jafar, W, Cowan, M, Ch'Ng, C, Rahman, M, Wesley, E, Jain, S, Mandal, A, Wright, M, Gordon, F, Unitt, E, Austin, A, Palegwala, A, Vemala, V, Higham, A, Fraser, J, Li, A, Ramakrishnan, S, King, A, Whalley, S, Gee, I, Keld, R, Fellows, H, Gotto, J, Millson, C, Murillo Perez C. F., Fisher H., Hiu S., Kareithi D., Adekunle F., Mayne T., Malecha E., Ness E., van der Meer A. J., Lammers W. J., Trivedi P. J., Battezzati P. M., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Pares A., Londono M. -C., Invernizzi P., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Gulamhusein A., Janssen H. L. A., Smith R., Flack S., Mulcahy V., Trauner M., Bowlus C. L., Lindor K. D., Corpechot C., Jones D., Mells G., Hirschfield G. M., Wason J., Hansen B. E., Sturgess R., Healey C., Gunasekera A., Kallis Y., Wright G., Mathialahan T., Evans R., Gasem J., Ramanaden D., Ward E., Bhalme M., Southern P., Maggs J., Yousif M., Srivastava B., Foxton M., Collins C., Prasad Y., Porras-Perez F., Yapp T., Patel M., Ede R., Carte M., Koss K., Sattianayagam P., Grimley C., Tidbury J., Mansour D., Beckley M., Hollywood C., Ramag J., Gordon H., Ridpath J., Grover B., Abouda G., Rees I., Narain M., Salam I., Banim P., Das D., Matthews H., Mohammed F., Jones R., Sen S., Bird G., Prince M., Prasad G., Kitchen P., Hutchinson J., Gupta P., Shah A., Saha S., Pollock K., Barclay S., McDonald N., Rushbrook S., Przemioslo R., Millar A., Mitchell S., Davis A., Naqvi A., Lee T., Ryder S., Collier J., Cramp M., Aspinal R., Booth J., Williams E., Hussaini H., Christie J., Chaudhry T., Mann S., Ala A., Maltby J., Corbett C., Singhal S., Hoeroldt B., Butterworth J., Douglas A., Sinha R., Panter S., Shearman J., Bray G., Roberts M., Forton D., Taylor N., Jafar W., Cowan M., Ch'ng C. L., Rahman M., Wesley E., Jain S., Mandal A., Wright M., Trivedi P., Gordon F., Unitt E., Austin A., Palegwala A., Vemala V., Higham A., Fraser J., Li A., Ramakrishnan S., King A., Whalley S., Gee I., Keld R., Fellows H., Gotto J., Millson C., Murillo Perez, C, Fisher, H, Hiu, S, Kareithi, D, Adekunle, F, Mayne, T, Malecha, E, Ness, E, van der Meer, A, Lammers, W, Trivedi, P, Battezzati, P, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Pares, A, Londono, M, Invernizzi, P, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Gulamhusein, A, Janssen, H, Smith, R, Flack, S, Mulcahy, V, Trauner, M, Bowlus, C, Lindor, K, Corpechot, C, Jones, D, Mells, G, Hirschfield, G, Wason, J, Hansen, B, Sturgess, R, Healey, C, Gunasekera, A, Kallis, Y, Wright, G, Mathialahan, T, Evans, R, Gasem, J, Ramanaden, D, Ward, E, Bhalme, M, Southern, P, Maggs, J, Yousif, M, Srivastava, B, Foxton, M, Collins, C, Prasad, Y, Porras-Perez, F, Yapp, T, Patel, M, Ede, R, Carte, M, Koss, K, Sattianayagam, P, Grimley, C, Tidbury, J, Mansour, D, Beckley, M, Hollywood, C, Ramag, J, Gordon, H, Ridpath, J, Grover, B, Abouda, G, Rees, I, Narain, M, Salam, I, Banim, P, Das, D, Matthews, H, Mohammed, F, Jones, R, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Hutchinson, J, Gupta, P, Shah, A, Saha, S, Pollock, K, Barclay, S, Mcdonald, N, Rushbrook, S, Przemioslo, R, Millar, A, Mitchell, S, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Cramp, M, Aspinal, R, Booth, J, Williams, E, Hussaini, H, Christie, J, Chaudhry, T, Mann, S, Ala, A, Maltby, J, Corbett, C, Singhal, S, Hoeroldt, B, Butterworth, J, Douglas, A, Sinha, R, Panter, S, Shearman, J, Bray, G, Roberts, M, Forton, D, Taylor, N, Jafar, W, Cowan, M, Ch'Ng, C, Rahman, M, Wesley, E, Jain, S, Mandal, A, Wright, M, Gordon, F, Unitt, E, Austin, A, Palegwala, A, Vemala, V, Higham, A, Fraser, J, Li, A, Ramakrishnan, S, King, A, Whalley, S, Gee, I, Keld, R, Fellows, H, Gotto, J, Millson, C, Murillo Perez C. F., Fisher H., Hiu S., Kareithi D., Adekunle F., Mayne T., Malecha E., Ness E., van der Meer A. J., Lammers W. J., Trivedi P. J., Battezzati P. M., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Pares A., Londono M. -C., Invernizzi P., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Gulamhusein A., Janssen H. L. A., Smith R., Flack S., Mulcahy V., Trauner M., Bowlus C. L., Lindor K. D., Corpechot C., Jones D., Mells G., Hirschfield G. M., Wason J., Hansen B. E., Sturgess R., Healey C., Gunasekera A., Kallis Y., Wright G., Mathialahan T., Evans R., Gasem J., Ramanaden D., Ward E., Bhalme M., Southern P., Maggs J., Yousif M., Srivastava B., Foxton M., Collins C., Prasad Y., Porras-Perez F., Yapp T., Patel M., Ede R., Carte M., Koss K., Sattianayagam P., Grimley C., Tidbury J., Mansour D., Beckley M., Hollywood C., Ramag J., Gordon H., Ridpath J., Grover B., Abouda G., Rees I., Narain M., Salam I., Banim P., Das D., Matthews H., Mohammed F., Jones R., Sen S., Bird G., Prince M., Prasad G., Kitchen P., Hutchinson J., Gupta P., Shah A., Saha S., Pollock K., Barclay S., McDonald N., Rushbrook S., Przemioslo R., Millar A., Mitchell S., Davis A., Naqvi A., Lee T., Ryder S., Collier J., Cramp M., Aspinal R., Booth J., Williams E., Hussaini H., Christie J., Chaudhry T., Mann S., Ala A., Maltby J., Corbett C., Singhal S., Hoeroldt B., Butterworth J., Douglas A., Sinha R., Panter S., Shearman J., Bray G., Roberts M., Forton D., Taylor N., Jafar W., Cowan M., Ch'ng C. L., Rahman M., Wesley E., Jain S., Mandal A., Wright M., Trivedi P., Gordon F., Unitt E., Austin A., Palegwala A., Vemala V., Higham A., Fraser J., Li A., Ramakrishnan S., King A., Whalley S., Gee I., Keld R., Fellows H., Gotto J., and Millson C.
Abstract: Background & Aims: The Primary Biliary Cholangitis (PBC) Obeticholic Acid (OCA) International Study of Efficacy (POISE) randomized, double-blind, placebo-controlled trial demonstrated that OCA reduced biomarkers associated with adverse clinical outcomes (ie, alkaline phosphatase, bilirubin, aspartate aminotransferase, and alanine aminotransferase) in patients with PBC. The objective of this study was to evaluate time to first occurrence of liver transplantation or death in patients with OCA in the POISE trial and open-label extension vs comparable non-OCA–treated external controls. Methods: Propensity scores were generated for external control patients meeting POISE eligibility criteria from 2 registry studies (Global PBC and UK-PBC) using an index date selected randomly between the first and last date (inclusive) on which eligibility criteria were met. Cox proportional hazards models weighted by inverse probability of treatment assessed time to death or liver transplantation. Additional analyses (Global PBC only) added hepatic decompensation to the composite end point and assessed efficacy in patients with or without cirrhosis. Results: During the 6-year follow-up, there were 5 deaths or liver transplantations in 209 subjects in the POISE cohort (2.4%), 135 of 1381 patients in the Global PBC control (10.0%), and 281 of 2135 patients in the UK-PBC control (13.2%). The hazard ratios (HRs) for the primary outcome were 0.29 (95% CI, 0.10–0.83) for POISE vs Global PBC and 0.30 (95% CI, 0.12–0.75) for POISE vs UK-PBC. In the Global PBC study, HR was 0.20 (95% CI, 0.03–1.22) for patients with cirrhosis and 0.31 (95% CI, 0.09–1.04) for those without cirrhosis; HR was 0.42 (95% CI, 0.21–0.85) including hepatic decompensation. Conclusions: Patients treated with OCA in a trial setting had significantly greater transplant-free survival than comparable external control patients.
Published: 2022

15. Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (Journal of Hepatology (2021) 75(3) (572–581), (S0168827821003342), (10.1016/j.jhep.2021.04.055))

Author: Cordell H. J., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byun, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Tarocchi, M, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byun J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M. C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V. J., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D. J., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J. W., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., Tarocchi M., Cordell H. J., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byun, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Tarocchi, M, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byun J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M. C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V. J., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D. J., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J. W., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., and Tarocchi M.
Abstract: It has come to our attention that the name of one of the authors in our manuscript was incorrectly spelled ‘Jinyoung Byan’; the correct spelling is ‘Jinyoung Byun’ as in the author list above. In addition, the excel files of the supplementary tables were not included during the online publication of our article. These have now been made available online. We apologize for any inconvenience caused.
Published: 2022

16. ARE WE MAKING BEST USE OF ASSISTIVE LISTENING SYSTEMS IN THEATRES

Author: REES, I, primary and JAMES, A, additional
Published: 2023
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17. Searches for small-scale anisotropies from neutrino point sources with three years of IceCube data

Author: Aartsen, M.G., Ackermann, M., Adams, J., Aguilar, J.A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T.C., Auffenberg, J., Bai, X., Barwick, S.W., Baum, V., Beatty, J.J., Becker Tjus, J., Becker, K.-H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D.Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D.J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H.-P., Brown, A.M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D.F., Cruz Silva, A.H., Danninger, M., Daughhetee, J., Davis, J.C., Day, M., de André, J.P.A.M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K.D., de With, M., DeYoung, T., Díaz-Vélez, J.C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T.K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J.G., Goodman, J.A., Góra, D., Grant, D., Gretskov, P., Groh, J.C., Groß, A., Ha, C., Haack, C., Haj Ismail, A., Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G.C., Hoffman, K.D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P.O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G.S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J.L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S.R., Köhne, J.-H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D.J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D.T., Larson, M.J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H.S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S.C., Nygren, D.R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O’Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J.A., Pérez de los Heros, C., Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P.B., Przybylski, G.T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J.P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S.M., Sander, H.-G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M.W.E., Soldin, D., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N.A., Stasik, A., Stezelberger, T., Stokstad, R.G., Stößl, A., Strahler, E.A., Ström, R., Strotjohann, N.L., Sullivan, G.W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P.A., Tobin, M.N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B.J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C.H., Williams, D.R., Wissing, H., Wolf, M., Wood, T.R., Woschnagg, K., Xu, D.L., Xu, X.W., Yanez, J.P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Published: 2015
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18. Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (Journal of Hepatology (2021) 75(3) (572–581), (S0168827821003342), (10.1016/j.jhep.2021.04.055))

Author: Cordell, H. J., Fryett, J. J., Ueno, K., Darlay, R., Aiba, Y., Hitomi, Y., Kawashima, M., Nishida, N., Khor, S. -S., Gervais, O., Kawai, Y., Nagasaki, M., Tokunaga, K., Tang, R., Shi, Y., Li, Z., Juran, B. D., Atkinson, E. J., Gerussi, A., Carbone, M., Asselta, R., Cheung, A., de Andrade, M., Baras, A., Horowitz, J., Ferreira, M. A. R., Sun, D., Jones, D. E., Flack, S., Spicer, A., Mulcahy, V. L., Byun, J., Han, Y., Sandford, R. N., Lazaridis, K. N., Amos, C. I., Hirschfield, G. M., Seldin, M. F., Invernizzi, P., Siminovitch, K. A., Ma, X., Nakamura, M., Mells, G. F., Mason, A., Vincent, C., Xie, G., Zhang, J., Affronti, A., Almasio, P. L., Alvaro, D., Andreone, P., Andriulli, A., Azzaroli, F., Battezzati, P. M., Benedetti, A., Bragazzi, M., Brunetto, M., Bruno, S., Calvaruso, V., Cardinale, V., Casella, G., Cazzagon, N., Ciaccio, A., Coco, B., Colli, A., Colloredo, G., Colombo, M., Colombo, S., Cristoferi, L., Cursaro, C., Croce, L. S., Crosignani, A., D'Amato, D., Donato, F., Elia, G., Fabris, L., Fagiuoli, S., Ferrari, C., Floreani, A., Galli, A., Giannini, E., Grattagliano, I., Lampertico, P., Lleo, A., Malinverno, F., Mancuso, C., Marra, F., Marzioni, M., Massironi, S., Mattalia, A., Miele, L., Milani, C., Morini, L., Morisco, F., Muratori, L., Muratori, P., Niro, G. A., O'Donnell, S., Picciotto, A., Portincasa, P., Rigamonti, C., Ronca, V., Rosina, F., Spinzi, G., Strazzabosco, M., Tarocchi, M., Tiribelli, C., Toniutto, P., Valenti, L., Vinci, M., Zuin, M., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Migita, K., Ohira, H., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Tanaka, A., Takikawa, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Kawata, K., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., H, E., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Chalasani, N., Luketic, V., Odin, J., Chopra, K., Abecasis, G., Cantor, M., Coppola, G., Economides, A., Lotta, L. A., Overton, J. D., Reid, J. G., Shuldiner, A., Beechert, C., Forsythe, C., Fuller, E. D., Gu, Z., Lattari, M., Lopez, A., Schleicher, T. D., Padilla, M. S., Toledo, K., Widom, L., Wolf, S. E., Pradhan, M., Manoochehri, K., Ulloa, R. H., Bai, X., Balasubramanian, S., Barnard, L., Blumenfeld, A., Eom, G., Habegger, L., Hawes, A., Khalid, S., Maxwell, E. K., Salerno, W., Staples, J. C., Jones, M. B., Mitnaul, L. J., Sturgess, R., Healey, C., Yeoman, A., Gunasekera, A. V., Kooner, P., Kapur, K., Sathyanarayana, V., Kallis, Y., Subhani, J., Harvey, R., Mccorry, R., Rooney, P., Ramanaden, D., Evans, R., Mathialahan, T., Gasem, J., Shorrock, C., Bhalme, M., Southern, P., Tibble, J. A., Gorard, D. A., Jones, S., Mells, G., Mulcahy, V., Srivastava, B., Foxton, M. R., Collins, C. E., Elphick, D., Karmo, M., Porras-Perez, F., Mendall, M., Yapp, T., Patel, M., Ede, R., Sayer, J., Jupp, J., Fisher, N., Carter, M. J., Koss, K., Shah, J., Piotrowicz, A., Scott, G., Grimley, C., Gooding, I. R., Williams, S., Tidbury, J., Lim, G., Cheent, K., Levi, S., Mansour, D., Beckley, M., Hollywood, C., Wong, T., Marley, R., Ramage, J., Gordon, H. M., Ridpath, J., Ngatchu, T., Bob Grover, V. P., Shidrawi, R. G., Abouda, G., Corless, L., Narain, M., Rees, I., Brown, A., Taylor-Robinson, S., Wilkins, J., Grellier, L., Banim, P., Das, D., Heneghan, M. A., Curtis, H., Matthews, H. C., Mohammed, F., Aldersley, M., Srirajaskanthan, R., Walker, G., Mcnair, A., Sharif, A., Sen, S., Bird, G., Prince, M. I., Prasad, G., Kitchen, P., Barnardo, A., Oza, C., Sivaramakrishnan, N. N., Gupta, P., Shah, A., Evans, C. D., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Barclay, S. T., Mcdonald, N., Bathgate, A. J., Palmer, K., Dillon, J. F., Rushbrook, S. M., Przemioslo, R., Mcdonald, C., Millar, A., Tai, C., Mitchell, S., Metcalf, J., Shaukat, S., Ninkovic, M., Shmueli, U., Davis, A., Naqvi, A., Lee, T. J., Ryder, S., Collier, J., Klass, H., Cramp, M. E., Sharer, N., Aspinall, R., Ghosh, D., Douds, A. C., Booth, J., Williams, E., Hussaini, H., Christie, J., Mann, S., Thorburn, D., Marshall, A., Patanwala, I., Ala, A., Maltby, J., Matthew, R., Corbett, C., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Mitchison, H., Panter, S., Shearman, J., Bray, G., Roberts, M., Butcher, G., Forton, D., Mahmood, Z., Cowan, M., Ch'Ng, C. L., Rahman, M., Whatley, G. C. A., Wesley, E., Mandal, A., Jain, S., Pereira, S. P., Wright, M., Trivedi, P., Gordon, F. H., Unitt, E., Palejwala, A., Austin, A., Vemala, V., Grant, A., Higham, A. D., Brind, A., Mathew, R., Cox, M., Ramakrishnan, S., King, A., Whalley, S., Fraser, J., Thomson, S. J., Bell, A., Wong, V. S., Kia, R., Gee, I., Keld, R., Ransford, R., Gotto, J., Millson, C., Cordell H.J., Fryett J.J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S.-S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B.D., Atkinson E.J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M.A.R., Sun D., Jones D.E., Flack S., Spicer A., Mulcahy V.L., Byun J., Han Y., Sandford R.N., Lazaridis K.N., Amos C.I., Hirschfield G.M., Seldin M.F., Invernizzi P., Siminovitch K.A., Ma X., Nakamura M., Mells G.F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P.L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P.M., Benedetti A., Bragazzi M.C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L.S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G.A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Toledo K., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Ulloa R.H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E.K., Salerno W., Staples J.C., Jones M.B., Mitnaul L.J., Sturgess R., Healey C., Yeoman A., Gunasekera A.V.J., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J.A., Gorard D.A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M.R., Collins C.E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M.J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I.R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H.M., Ridpath J., Ngatchu T., Bob Grover V.P., Shidrawi R.G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M.A., Curtis H., Matthews H.C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M.I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N.N., Gupta P., Shah A., Evans C.D.J., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S.T., McDonald N., Bathgate A.J., Palmer K., Dillon J.F., Rushbrook S.M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T.J.W., Ryder S., Collier J., Klass H., Cramp M.E., Sharer N., Aspinall R., Ghosh D., Douds A.C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C.L., Rahman M., Whatley G.C.A., Wesley E., Mandal A., Jain S., Pereira S.P., Wright M., Trivedi P., Gordon F.H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A.D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S.J., Bell A., Wong V.S., Kia R., Gee I., Keld R., Ransford R., Gotto J., and Millson C.
Subjects: PBC
Abstract: It has come to our attention that the name of one of the authors in our manuscript was incorrectly spelled ‘Jinyoung Byan’; the correct spelling is ‘Jinyoung Byun’ as in the author list above. In addition, the excel files of the supplementary tables were not included during the online publication of our article. These have now been made available online. We apologize for any inconvenience caused.
Published: 2022

19. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., and Invernizzi P.
Abstract: Background & Aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10–4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10–6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028–1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09–1.26; P = 9.93 × 10–8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10–9; OR, 1.33; 95% CI, 1.21–1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

20. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author: Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tarocchi, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tarocchi, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., and Millson C.
Abstract: Backgrounds & Aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. Methods: We combined new and existing genotype data for 10,516 cases and 20,772 controls from 5 European and 2 East Asian cohorts. Results: We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, which each play key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, JAK-STAT signalling, and differentiation of T helper (TH)1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some of which are well-established in the treatment of other autoimmune disorders. Conclusions: This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders. Lay summary: Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we analysed genetic information from 10,516 people with PBC and 20,772 healthy individuals recruited in Canada, China
Published: 2021

21. Development of a general analysis and unfolding scheme and its application to measure the energy spectrum of atmospheric neutrinos with IceCube: IceCube Collaboration

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K.-H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Cruz Silva, A. H., Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Haj Ismail, A., Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O’Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Pérez de los Heros, C., Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H.-G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., and Morik, K.
Published: 2015
Full Text: View/download PDF

22. Multipole analysis of IceCube data to search for dark matter accumulated in the Galactic halo: IceCube Collaboration

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Becker Tjus, J., Becker, K.-H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H.-P., Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Cruz Silva, A. H., Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Haj Ismail, A., Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J.-H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O’Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Pérez de los Heros, C., Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H.-G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Published: 2015
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23. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, Federica, Fagiuoli, Stefano, Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, Luca, Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, Maria Rosaria, Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Donato F., Fagiuoli S., Miele L. (ORCID:0000-0003-3464-0068), Vinci M., Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, Federica, Fagiuoli, Stefano, Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, Luca, Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, Maria Rosaria, Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Donato F., Fagiuoli S., Miele L. (ORCID:0000-0003-3464-0068), and Vinci M.
Abstract: Background & Aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10–4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10–6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028–1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09–1.26; P = 9.93 × 10–8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10–9; OR, 1.33; 95% CI, 1.21–1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

24. Identification of Three Distinct Phylogenetic Groups of CAX Cation/Proton Antiporters

Author: Shigaki, T., Rees, I., Nakhleh, L., and Hirschi, K.D.
Published: 2006
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25. Coupled and uncoupled contaminant transport using advanced finite volume methods

Author: Lewis, R. W., Masters, I., and Rees, I.
Published: 2006
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26. Allgemeine Naturgeschichte für alle Stände

Author: Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, C. Susemihl & Sohn, Missouri Botanical Garden, Peter H. Raven Library, NCSU Libraries, Smithsonian Libraries and Archives, Saint Louis Public Library, Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, and C. Susemihl & Sohn
Subjects: Anatomy, Biology, Botany, Geology, Mineralogy, Natural history, Zoology
Published: 1833

27. HEP Applications and Their Experience with the Use of DataGrid Middleware

Author: Burke, S., Harris, F., Stokes-Rees, I., Augustin, I., Carminati, F., Closier, J., van Herwijnen, E., Sciaba, A., Boutigny, D., Blaising, J. J., Garonne, V., Tsaregorodtsev, A., Capiluppi, P., Fanfani, A., Grandi, C., Barbera, R., Luppi, E., Negri, G., Perini, L., Resconi, S., Reale, M., De Salvo, A., Bagnasco, S., Cerello, P., Bos, K., Groep, D., van Leeuwen, W., Templon, J., Smirnova, O., Maroney, O., Brochu, F., and Colling, D.
Published: 2004
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28. Allgemeine Naturgeschichte für alle Stände

Author: Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, C. Susemihl & Sohn, Smithsonian Libraries and Archives, Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, and C. Susemihl & Sohn
Subjects: Anatomy, Biology, Botany, Geology, Mineralogy, Natural history, Zoology

29. Allgemeine Naturgeschichte für alle Stände

Author: Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, C. Susemihl & Sohn, Smithsonian Libraries and Archives, Oken, Lorenz, 1779-1851, Walchner, Friedrich August, 1799-1865, Kull, Conrad, 1816-1897, Schleich, Adrian, 1812-1894, Löffler, C., active 1840, Mayer, Carl, 1798-1868, Rees, I., active 1830, Schillinger, St., active 1840, Schach, Carl, Soltükow, Th, C. Hoffmann'Sche Verlagshandlung, and C. Susemihl & Sohn
Subjects: Anatomy, Biology, Botany, Geology, Mineralogy, Natural history, Zoology

30. BHP Petroleum's Methanol Research Project

Author: Rees, I., primary
Published: 1994
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31. Design of Luminescent Polymers for Leds

Author: Holmes, A. B., Bond, A. D., Davies, J. E., Fischmeister, C., Frey, J., Hennecke, U., Li, J., Ma, Y., Martin, R. E., Rees, I. D., Robinson, K., Sano, T., Cacialli, F., Lim, S. F., and Friend, R. H.
Published: 2001
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32. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author: Carbone, M, Nardi, A, Flack, S, Carpino, G, Varvaropoulou, N, Gavrila, C, Spicer, A, Badrock, J, Bernuzzi, F, Cardinale, V, Ainsworth, H, Heneghan, M, Thorburn, D, Bathgate, A, Jones, R, Neuberger, J, Battezzati, P, Zuin, M, Taylor-Robinson, S, Donato, M, Kirby, J, Mitchell-Thain, R, Floreani, A, Sampaziotis, F, Muratori, L, Alvaro, D, Marzioni, M, Miele, L, Marra, F, Giannini, E, Gaudio, E, Ronca, V, Bonato, G, Cristoferi, L, Malinverno, F, Gerussi, A, Stocken, D, Cordell, H, Hirschfield, G, Alexander, G, Sandford, R, Jones, D, Invernizzi, P, Mells, G, Thomas, C, Rahman, M, Yapp, T, Lye Ch'ng, C, Harrison, M, Sturgess, R, Galaska, R, Healey, C, Whiteman, J, Czaijkowski, M, Gray, C, Gunasekera, A, Gyawli, P, Premchand, P, Mann, S, Elliott, K, Kapur, K, Watson, A, Foster, G, Trembling, P, Subhani, J, Harvey, R, Mccorry, R, Adgey, C, Hobson, L, Mulvaney-Jones, C, Evans, R, Mathialahan, T, Ramanaden, D, Gasem, J, Van Duyvenvoorde, G, Shorrock, C, Seward, K, Southern, P, Tibble, J, Penn, R, Gorard, D, Maiden, J, Damant, R, Palegwala, A, Jones, S, Dolwani, S, Prince, M, Silvestre, V, Foxton, M, Dungca, E, Mitchison, H, Wheatley, N, Gooding, I, Doyle, H, Karmo, M, Kent, M, Saksena, S, Braim, D, Patel, M, Lord, S, Ede, R, Paton, A, Austin, A, Lancaster, N, Sayer, J, Gibbins, A, Hogben, K, Hovell, C, Fisher, N, Carter, M, Koss, K, Musselwhite, J, Muscariu, F, Piotreowicz, A, Mckay, A, Grimley, C, Neal, D, Ting Tan, L, Lim, G, Brighton, J, Foale, C, Ala, A, Saeed, A, Flahive, K, Wood, G, Townshend, P, Ford, C, Brown, J, Kordula, J, Bowles, J, Wilkinson, M, Palmer, C, Ramage, J, Gordon, H, Featherstone, J, Ridpath, J, Ngatchu, T, Levi, S, Shaukat, S, Sadeghian, J, Shidrawi, R, Williams, B, Abouda, G, Duggan, C, Hynes, A, Narain, M, Rees, I, Salam, I, Crossey, M, Brown, A, Macnicol, C, Williams, S, Wilhelmsen, E, Banim, P, Raymode, P, Chilton, A, Das, D, Lee, H, Curtis, H, Gess, M, Durant, E, Drake, I, Bishop, R, Davies, M, Aldersley, M, Ncube, N, Mcnair, A, Srirajaskanthan, R, Sen, S, Casey, R, Bird, G, Mendall, M, Cowley, C, Barnardo, A, Kitchen, P, Yoong, K, Amore, K, Sirdefield, D, Orpe, J, Mathew, R, Macfaul, G, Wrigth, A, Shah, A, Evans, C, Keggans, J, Bird, B, Baxter, G, Saha, S, Pollock, K, Hughes, M, Bramley, P, Grieve, E, Young, K, Fraser, A, Mukhopadhya, A, Ocker, K, Mills, P, Hines, F, Shallcross, C, Wilkins, J, Grellier, L, Campbell, S, Martin, K, Innes, C, Shepherd, A, Rushbrook, S, Valliani, T, Przemioslo, R, Fairlamb, H, Macdonald, C, Eastick, A, Metcalf, J, Tanqueray, E, Shmueli, U, Holbrook, B, Davis, A, Browning, J, Naqvi, A, Walker, K, Lee, T, Verheyden, J, Slininger, S, Ryder, S, Chapman, R, Collier, J, O'Donnell, D, Stafford, L, Williamson, K, Kent, L, Klass, H, Ninkovic, M, March, L, Cramp, M, Simpson, D, Dickson, C, Sharer, N, Hayes, M, Goggin, P, Quinne, M, Pearson, S, Hoeroldt, B, Jones, L, Wright, A, Booth, J, Loftus, A, Lipscomb, G, Dewhurst, H, Gunter, E, Williams, E, Fouracres, A, Farrington, L, Graves, L, Hussaini, H, Stableforth, B, Marriott, S, Ayres, R, Leoni, M, Burroughs, A, Marshall, E, Tyrer, D, Lombard, M, Patanwala, I, Dali-Kemmery, L, Lambourne, V, Maltby, J, Vyas, S, Colley, J, Shinder, B, Singhal, S, Jones, J, Mills, M, Gleeson, D, Carnahan, M, Butterworth, J, Boulton, K, Taylor, N, George, K, Harding, T, Tregonning, J, Douglass, A, Brown, C, Clifford, G, Panter, S, Gocher, D, Shearman, J, Bray, G, Hamilton, M, Butcher, G, Forton, D, Mclindon, J, Curtis, J, Shewan, T, Cowan, M, Whatley, G, Nasseri, M, Grover, B, Sivaramakrishnan, N, Ducker, S, Houghton, K, Griffiths, L, Tripoli, S, Pitcher, M, Shpuza, E, White, N, Ghosh, D, Douds, A, Green, M, Brookes, M, Cumlat, L, Wong, V, Warner, K, Netherton, K, Mandal, A, Jain, S, Gupta, H, Sanghi, P, Pereira, S, Gunson, B, Lim, R, Gallagher, S, Clement, D, Brind, A, Watts, G, Mupudzi, M, Wright, M, Gitahi, J, Gordon, F, Unitt, E, Pateman, H, Batham, S, Delahooke, T, Grant, A, Conder, J, Higham, A, Cox, M, O'Donohoe, L, Currie, L, King, A, Oblak, M, Collins, C, Whalley, S, Quinn, M, Baird, Y, Amey, I, Fraser, J, Li, A, Cotterill, D, Bell, A, Singhal, A, Gee, I, Greer, S, Ang, Y, Ransford, R, Allison, J, Gotto, J, Dyer, S, Sweeting, H, Millson, C, Labbadia, G, Bragazzi, M, Andreone, P, Azzaroli, F, Galli, A, Tarocchi, M, Gasbarrini, A, Grieco, A, Marrone, G, Valenti, L, Maroni, L, Rigamonti, C, Picciotto, A, Carbone, Marco, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Bernuzzi, Francesca, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Thorburn, Douglas, Bathgate, Andrew, Jones, Rebecca, Neuberger, James M, Battezzati, Pier Maria, Zuin, Massimo, Taylor-Robinson, Simon, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Floreani, Annarosa, Sampaziotis, Fotios, Muratori, Luigi, Alvaro, Domenico, Marzioni, Marco, Miele, Luca, Marra, Fabio, Giannini, Edoardo, Gaudio, Eugenio, Ronca, Vincenzo, Bonato, Giulia, Cristoferi, Laura, Malinverno, Federica, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, Invernizzi, Pietro, Mells, George F, Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, I. M., Bishop, Rebecca, Davies, Mervyn, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Azzaroli, Francesco, Galli, Andrea, Tarocchi, Mirko, Gasbarrini, Antonio, GRIECO, ANTONIO, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Maroni, Luca, Rigamonti, Cristina, Picciotto, Antonino, Carbone, M, Nardi, A, Flack, S, Carpino, G, Varvaropoulou, N, Gavrila, C, Spicer, A, Badrock, J, Bernuzzi, F, Cardinale, V, Ainsworth, H, Heneghan, M, Thorburn, D, Bathgate, A, Jones, R, Neuberger, J, Battezzati, P, Zuin, M, Taylor-Robinson, S, Donato, M, Kirby, J, Mitchell-Thain, R, Floreani, A, Sampaziotis, F, Muratori, L, Alvaro, D, Marzioni, M, Miele, L, Marra, F, Giannini, E, Gaudio, E, Ronca, V, Bonato, G, Cristoferi, L, Malinverno, F, Gerussi, A, Stocken, D, Cordell, H, Hirschfield, G, Alexander, G, Sandford, R, Jones, D, Invernizzi, P, Mells, G, Thomas, C, Rahman, M, Yapp, T, Lye Ch'ng, C, Harrison, M, Sturgess, R, Galaska, R, Healey, C, Whiteman, J, Czaijkowski, M, Gray, C, Gunasekera, A, Gyawli, P, Premchand, P, Mann, S, Elliott, K, Kapur, K, Watson, A, Foster, G, Trembling, P, Subhani, J, Harvey, R, Mccorry, R, Adgey, C, Hobson, L, Mulvaney-Jones, C, Evans, R, Mathialahan, T, Ramanaden, D, Gasem, J, Van Duyvenvoorde, G, Shorrock, C, Seward, K, Southern, P, Tibble, J, Penn, R, Gorard, D, Maiden, J, Damant, R, Palegwala, A, Jones, S, Dolwani, S, Prince, M, Silvestre, V, Foxton, M, Dungca, E, Mitchison, H, Wheatley, N, Gooding, I, Doyle, H, Karmo, M, Kent, M, Saksena, S, Braim, D, Patel, M, Lord, S, Ede, R, Paton, A, Austin, A, Lancaster, N, Sayer, J, Gibbins, A, Hogben, K, Hovell, C, Fisher, N, Carter, M, Koss, K, Musselwhite, J, Muscariu, F, Piotreowicz, A, Mckay, A, Grimley, C, Neal, D, Ting Tan, L, Lim, G, Brighton, J, Foale, C, Ala, A, Saeed, A, Flahive, K, Wood, G, Townshend, P, Ford, C, Brown, J, Kordula, J, Bowles, J, Wilkinson, M, Palmer, C, Ramage, J, Gordon, H, Featherstone, J, Ridpath, J, Ngatchu, T, Levi, S, Shaukat, S, Sadeghian, J, Shidrawi, R, Williams, B, Abouda, G, Duggan, C, Hynes, A, Narain, M, Rees, I, Salam, I, Crossey, M, Brown, A, Macnicol, C, Williams, S, Wilhelmsen, E, Banim, P, Raymode, P, Chilton, A, Das, D, Lee, H, Curtis, H, Gess, M, Durant, E, Drake, I, Bishop, R, Davies, M, Aldersley, M, Ncube, N, Mcnair, A, Srirajaskanthan, R, Sen, S, Casey, R, Bird, G, Mendall, M, Cowley, C, Barnardo, A, Kitchen, P, Yoong, K, Amore, K, Sirdefield, D, Orpe, J, Mathew, R, Macfaul, G, Wrigth, A, Shah, A, Evans, C, Keggans, J, Bird, B, Baxter, G, Saha, S, Pollock, K, Hughes, M, Bramley, P, Grieve, E, Young, K, Fraser, A, Mukhopadhya, A, Ocker, K, Mills, P, Hines, F, Shallcross, C, Wilkins, J, Grellier, L, Campbell, S, Martin, K, Innes, C, Shepherd, A, Rushbrook, S, Valliani, T, Przemioslo, R, Fairlamb, H, Macdonald, C, Eastick, A, Metcalf, J, Tanqueray, E, Shmueli, U, Holbrook, B, Davis, A, Browning, J, Naqvi, A, Walker, K, Lee, T, Verheyden, J, Slininger, S, Ryder, S, Chapman, R, Collier, J, O'Donnell, D, Stafford, L, Williamson, K, Kent, L, Klass, H, Ninkovic, M, March, L, Cramp, M, Simpson, D, Dickson, C, Sharer, N, Hayes, M, Goggin, P, Quinne, M, Pearson, S, Hoeroldt, B, Jones, L, Wright, A, Booth, J, Loftus, A, Lipscomb, G, Dewhurst, H, Gunter, E, Williams, E, Fouracres, A, Farrington, L, Graves, L, Hussaini, H, Stableforth, B, Marriott, S, Ayres, R, Leoni, M, Burroughs, A, Marshall, E, Tyrer, D, Lombard, M, Patanwala, I, Dali-Kemmery, L, Lambourne, V, Maltby, J, Vyas, S, Colley, J, Shinder, B, Singhal, S, Jones, J, Mills, M, Gleeson, D, Carnahan, M, Butterworth, J, Boulton, K, Taylor, N, George, K, Harding, T, Tregonning, J, Douglass, A, Brown, C, Clifford, G, Panter, S, Gocher, D, Shearman, J, Bray, G, Hamilton, M, Butcher, G, Forton, D, Mclindon, J, Curtis, J, Shewan, T, Cowan, M, Whatley, G, Nasseri, M, Grover, B, Sivaramakrishnan, N, Ducker, S, Houghton, K, Griffiths, L, Tripoli, S, Pitcher, M, Shpuza, E, White, N, Ghosh, D, Douds, A, Green, M, Brookes, M, Cumlat, L, Wong, V, Warner, K, Netherton, K, Mandal, A, Jain, S, Gupta, H, Sanghi, P, Pereira, S, Gunson, B, Lim, R, Gallagher, S, Clement, D, Brind, A, Watts, G, Mupudzi, M, Wright, M, Gitahi, J, Gordon, F, Unitt, E, Pateman, H, Batham, S, Delahooke, T, Grant, A, Conder, J, Higham, A, Cox, M, O'Donohoe, L, Currie, L, King, A, Oblak, M, Collins, C, Whalley, S, Quinn, M, Baird, Y, Amey, I, Fraser, J, Li, A, Cotterill, D, Bell, A, Singhal, A, Gee, I, Greer, S, Ang, Y, Ransford, R, Allison, J, Gotto, J, Dyer, S, Sweeting, H, Millson, C, Labbadia, G, Bragazzi, M, Andreone, P, Azzaroli, F, Galli, A, Tarocchi, M, Gasbarrini, A, Grieco, A, Marrone, G, Valenti, L, Maroni, L, Rigamonti, C, Picciotto, A, Carbone, Marco, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Bernuzzi, Francesca, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Thorburn, Douglas, Bathgate, Andrew, Jones, Rebecca, Neuberger, James M, Battezzati, Pier Maria, Zuin, Massimo, Taylor-Robinson, Simon, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Floreani, Annarosa, Sampaziotis, Fotios, Muratori, Luigi, Alvaro, Domenico, Marzioni, Marco, Miele, Luca, Marra, Fabio, Giannini, Edoardo, Gaudio, Eugenio, Ronca, Vincenzo, Bonato, Giulia, Cristoferi, Laura, Malinverno, Federica, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, Invernizzi, Pietro, Mells, George F, Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, I. M., Bishop, Rebecca, Davies, Mervyn, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Azzaroli, Francesco, Galli, Andrea, Tarocchi, Mirko, Gasbarrini, Antonio, GRIECO, ANTONIO, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Maroni, Luca, Rigamonti, Cristina, and Picciotto, Antonino
Abstract: Background: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters. Methods: We did logistic regression analysis of pretreatment variables in a discovery cohort of patients in the UK with primary biliary cholangitis to derive the best-fitting model of UDCA response, defined as alkaline phosphatase less than 1·67 times the upper limit of normal (ULN), measured after 12 months of treatment with UDCA. We validated the model in an external cohort of patients with primary biliary cholangitis and treated with UDCA in Italy. Additionally, we assessed correlations between model predictions and key histological features, such as biliary injury and fibrosis, on liver biopsy samples. Findings: 2703 participants diagnosed with primary biliary cholangitis between Jan 1, 1998, and May 31, 2015, were included in the UK-PBC cohort for derivation of the model. The following pretreatment parameters were associated with lower probability of UDCA response: higher alkaline phosphatase concentration (p<0·0001), higher total bilirubin concentration (p=0·0003), lower aminotransferase concentration (p=0·0012), younger age (p<0·0001), longer interval from diagnosis to the start of UDCA treatment (treatment time lag, p<0·0001), and worsening of alkaline phosphatase concentration from diagnosis (p<0·0001). Based on these variables, we derived a predictive score of UDCA response. In the external validation cohort, 460 patients diagnosed with primary biliary cholangitis were treated with UDCA, with follow-up data until May 31, 2016. In this validation cohort, the area under the re
Published: 2018

33. The UK-PBC Risk Scores: Derivation and Validation of a Scoring System for Long-Term Prediction of End-Stage Liver Disease in Primary Biliary Cholangitis

Author: CARBONE, MARCO, Sharp, S, Flack, S, Paximadas, D, Spiess, K, Adgey, C, Griffiths, L, Lim, R, Trembling, P, Williamson, K, Wareham, N, Aldersley, M, Bathgate, A, Burroughs, A, Heneghan, M, Neuberger, J, Thorburn, D, Hirschfield, G, Cordell, H, Alexander, G, Jones, D, Sandford, R, Mells, G, Kirby, J, Taylor Robinson, S, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Williams, S, Grellier, L, Banim, P, Chilton, A, Curtis, H, Gess, M, Drake, I, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Marshall, E, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Das, D, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Null, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, Denise O'Donnell, N, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, Lynn O'Donohoe, N, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordul, J., Carbone, M, Sharp, S, Flack, S, Paximadas, D, Spiess, K, Adgey, C, Griffiths, L, Lim, R, Trembling, P, Williamson, K, Wareham, N, Aldersley, M, Bathgate, A, Burroughs, A, Heneghan, M, Neuberger, J, Thorburn, D, Hirschfield, G, Cordell, H, Alexander, G, Jones, D, Sandford, R, Mells, G, Kirby, J, Taylor Robinson, S, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Williams, S, Grellier, L, Banim, P, Chilton, A, Curtis, H, Gess, M, Drake, I, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Marshall, E, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Das, D, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Null, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, Denise O'Donnell, N, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, Lynn O'Donohoe, N, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, and Kordul, J
Subjects: Male, medicine.medical_specialty, Prognostic variable, Cholangitis, Risk Assessment, Article, Biliary disease, End Stage Liver Disease, 03 medical and health sciences, 0302 clinical medicine, Primary biliary cirrhosis, Retrospective Studie, Internal medicine, medicine, Humans, Retrospective Studies, Hepatology, business.industry, Proportional hazards model, Cholangiti, Ursodeoxycholic Acid, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Algorithm, 030220 oncology & carcinogenesis, Cohort, 030211 gastroenterology & hepatology, Female, business, Risk assessment, Algorithms, Human
Abstract: The biochemical response to ursodeoxycholic acid (UDCA)—so-called “treatment response”—strongly predicts long-term outcome in primary biliary cholangitis (PBC). Several long-term prognostic models based solely on the treatment response have been developed that are widely used to risk stratify PBC patients and guide their management. However, they do not take other prognostic variables into account, such as the stage of the liver disease. We sought to improve existing long-term prognostic models of PBC using data from the UK-PBC Research Cohort. We performed Cox's proportional hazards regression analysis of diverse explanatory variables in a derivation cohort of 1,916 UDCA-treated participants. We used nonautomatic backward selection to derive the best-fitting Cox model, from which we derived a multivariable fractional polynomial model. We combined linear predictors and baseline survivor functions in equations to score the risk of a liver transplant or liver-related death occurring within 5, 10, or 15 years. We validated these risk scores in an independent cohort of 1,249 UDCA-treated participants. The best-fitting model consisted of the baseline albumin and platelet count, as well as the bilirubin, transaminases, and alkaline phosphatase, after 12 months of UDCA. In the validation cohort, the 5-, 10-, and 15-year risk scores were highly accurate (areas under the curve: >0.90). Conclusions: The prognosis of PBC patients can be accurately evaluated using the UK-PBC risk scores. They may be used to identify high-risk patients for closer monitoring and second-line therapies, as well as low-risk patients who could potentially be followed up in primary care. (Hepatology 2016;63:930–950)
Published: 2015

34. Multimessenger search for sources of gravitational waves and high-energy neutrinos: Initial results for LIGO-Virgo and IceCube

Author: Aartsen, M. G., Ackermann, Markus, Auffenberg, J., Hebecker, D., Schutz, B. F., Scott, J., Scott, S. M., Sellers, D., Sengupta, A. S., Sentenac, D., Sequino, V., Sergeev, A., Shaddock, D. A., Shah, S., Heereman, D., Shahriar, M. S., Shaltev, M., Shao, Z., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sidery, T. L., Siellez, K., Siemens, X., Sigg, D., Heinen, D., Simakov, D., Singer, A., Singer, L., Singh, R., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., Smith, J. R., Smith, M. R., Smith, R. J. E., Helbing, K., Smith-Lefebvre, N. D., Son, E. J., Sorazu, B., Souradeep, T., Staley, A., Stebbins, J., Steinke, M., Steinlechner, J., Steinlechner, S., Stephens, B. C., Hellauer, R., Steplewski, S., Stevenson, S., Stone, R., Stops, D., Strain, K. A., Straniero, N., Strigin, S., Sturani, R., Stuver, A. L., Summerscales, T. Z., Hellwig, D., Susmithan, S., Sutton, P. J., Swinkels, B., Tacca, M., Talukder, D., Tanner, D. B., Tao, J., Tarabrin, S. P., Taylor, R., Tellez, G., Hickford, S., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thorne, K. A., Thorne, K. S., Thrane, E., Tiwari, V., Tokmakov, K. V., Tomlinson, C., Tonelli, M., Hill, G. C., Torres, C. V., Torrie, C. I., Travasso, F., Traylor, G., Tse, M., Tshilumba, D., Tuennermann, H., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Hoffman, K. D., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., Vallisneri, M., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., van der Sluys, M. V., van Heijningen, J., Hoffmann, R., van Veggel, A. A., Vass, S., Vasúth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Verkindt, D., Bai, X., Homeier, A., Vetrano, F., Viceré, A., Vincent-Finley, R., Vinet, J.-Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vousden, W. D., Vyachanin, S. P., Hoshina, K., Wade, A. R., Wade, L., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, M., Wang, X., Ward, R. L., Was, M., Huang, F., Weaver, B., Wei, L.-W., Weinert, M., Weinstein, A. J., Weiss, R., Welborn, T., Wen, L., Wessels, P., West, M., Westphal, T., Huelsnitz, W., Wette, K., Whelan, J. T., White, D. J., Whiting, B. F., Wiesner, K., Wilkinson, C., Williams, K., Williams, L., Williams, R., Williams, T. D., Hulth, P. O., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M., Winkler, W., Wipf, C. C., Wiseman, A. G., Wittel, H., Woan, G., Wolovick, N., Hultqvist, K., Worden, J., Wu, Y., Yablon, J., Yakushin, I., Yam, W., Yamamoto, H., Yancey, C. C., Yang, H., Yoshida, S., Yvert, M., Hussain, S., Zadrożny, A., Zanolin, M., Zendri, J.-P., Zhang, L., Zhao, C., Zhu, H., Zhu, X. J., Zucker, M. E., Zuraw, S., Zweizig, J., Ishihara, A., IceCube Collaboration, LIGO Scientific Collaboration, Virgo Collaboration, Goldschmidt, A., Groß, A., Ha, C., Sarkar, S., Schmidt, T., Schulte, L., Schukraft, A., Jacobi, E., Yanez, Juan Pablo, Birch, J., Chen, Y., Christensen, N., Ghosh, S., Nanda Kumar, D., Mukherjee, S., Schreiber, E., Zhang, Fan, Jacobsen, J., Barwick, S. W., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Baum, V., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J.-H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Beatty, J. J., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Becker Tjus, J., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Lünemann, J., Macías, O., Madsen, J., Becker, K.-H., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., BenZvi, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Berghaus, P., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O’Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Berley, D., Pepper, J. A., Pérez de los Heros, C., Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Adams, J., Bernardini, E., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Bernhard, A., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H.-G., Sandroos, J., Besson, D. Z., Santander, M., Schatto, K., Scheriau, F., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schulz, O., Seckel, D., Sestayo, Y., Binder, G., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Bindig, D., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Taavola, H., Taboada, I., Bissok, M., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Blaufuss, E., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Blumenthal, J., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Boersma, D. J., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yodh, G., Zarzhitsky, P., Bohm, C., Ziemann, J., Zierke, S., Zoll, M., Aasi, J., Abbott, B. P., Abbott, R., Abbott, T., Abernathy, M. R., Acernese, F., Ackley, K., Aguilar, J. A., Bos, F., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Affeldt, C., Agathos, M., Aggarwal, N., Aguiar, O. D., Ajith, P., Alemic, A., Bose, D., Allen, B., Allocca, A., Amariutei, D., Andersen, M., Anderson, R. A., Anderson, S. B., Anderson, W. G., Arai, K., Araya, M. C., Arceneaux, C., Böser, S., Areeda, J. S., Ast, S., Aston, S. M., Astone, P., Aufmuth, P., Augustus, H., Aulbert, C., Aylott, B. E., Babak, S., Baker, P. T., Botner, O., Ballardin, G., Ballmer, S. W., Barayoga, J. C., Barbet, M., Barish, B. C., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Brayeur, L., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Bauchrowitz, J., Bauer, Th. S., Baune, C., Bavigadda, V., Behnke, B., Bretz, H.-P., Bejger, M., Beker, M. 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D., Carbognani, F., Carbone, L., Caride, S., Clark, K., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Celerier, C., Cella, G., Cepeda, C., Cesarini, E., Chakraborty, R., Classen, L., Chalermsongsak, T., Chamberlin, S. J., Chao, S., Charlton, P., Chassande-Mottin, E., Chen, X., Chincarini, A., Chiummo, A., Cho, H. S., Cho, M., Clevermann, F., Chow, J. H., Chu, Q., Chua, S. S. Y., Chung, S., Ciani, G., Clara, F., Clark, D. E., Clark, J. A., Clayton, J. H., Cleva, F., Coenders, S., Coccia, E., Cohadon, P.-F., Colla, A., Collette, C., Colombini, M., Cominsky, L., Constancio, M., Conte, A., Cook, D., Corbitt, T. R., Cowen, D. F., Cornish, N., Corsi, A., Costa, C. A., Coughlin, M. W., Coulon, J.-P., Countryman, S., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Cruz Silva, A. H., Coyne, R., Craig, K., Creighton, J. D. E., Croce, R. P., Crowder, S. G., Cumming, A., Cunningham, L., Cuoco, E., Cutler, C., Dahl, K., Danninger, M., Dal Canton, T., Damjanic, M., Danilishin, S. L., D’Antonio, S., Danzmann, K., Dattilo, V., Daveloza, H., Davier, M., Davies, G. S., Daw, E. J., Daughhetee, J., Day, R., Dayanga, T., DeBra, D., Debreczeni, G., Degallaix, J., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Ahrens, M., Davis, J. C., Dereli, H., Dergachev, V., De Rosa, R., DeRosa, R. T., DeSalvo, R., Dhurandhar, S., Díaz, M., Dickson, J., Di Fiore, L., Di Lieto, A., Day, M., Di Palma, I., Di Virgilio, A., Dolique, V., Dominguez, E., Donovan, F., Dooley, K. L., Doravari, S., Douglas, R., Downes, T. P., Drago, M., de André, J. P. A. M., Drever, R. W. P., Driggers, J. C., Du, Z., Ducrot, M., Dwyer, S., Eberle, T., Edo, T., Edwards, M., Effler, A., Eggenstein, H.-B., De Clercq, C., Ehrens, P., Eichholz, J., Eikenberry, S. S., Endrőczi, G., Essick, R., Etzel, T., Evans, M., Evans, T., Factourovich, M., Fafone, V., De Ridder, S., Fairhurst, S., Fan, X., Fang, Q., Farinon, S., Farr, B., Farr, W. M., Favata, M., Fazi, D., Fehrmann, H., Fejer, M. M., Desiati, P., Feldbaum, D., Feroz, F., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Finn, L. S., Fiori, I., Fisher, R. P., Flaminio, R., de Vries, K. D., Fournier, J.-D., Franco, S., Frasca, S., Frasconi, F., Frede, M., Frei, Z., Freise, A., Frey, R., Fricke, T. T., Fritschel, P., de With, M., Frolov, V. V., Fulda, P., Fyffe, M., Gair, J. R., Gammaitoni, L., Gaonkar, S., Garufi, F., Gehrels, N., Gemme, G., Gendre, B., DeYoung, T., Genin, E., Gennai, A., Giaime, J. A., Giardina, K. D., Giazotto, A., Gleason, J., Goetz, E., Goetz, R., Gondan, L., González, G., Díaz-Vélez, J. C., Gordon, N., Gorodetsky, M. L., Gossan, S., Goßler, S., Gouaty, R., Gräf, C., Graff, P. B., Granata, M., Grant, A., Gras, S., Altmann, D., Dunkman, M., Gray, C., Greenhalgh, R. J. S., Gretarsson, A. M., Groot, P., Grote, H., Grover, K., Grunewald, S., Guidi, G. M., Guido, C. J., Gushwa, K., Eagan, R., Gustafson, E. K., Gustafson, R., Ha, J., Hall, E. D., Hamilton, W., Hammer, D., Hammond, G., Hanke, M., Hanks, J., Hanna, C., Eberhardt, B., Hannam, M. D., Hanson, J., Harms, J., Harry, G. M., Harry, I. W., Harstad, E. D., Hart, M., Hartman, M. T., Haster, C.-J., Haughian, K., Eichmann, B., Heidmann, A., Heintze, M., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Heptonstall, A. W., Heurs, M., Hewitson, M., Eisch, J., Hild, S., Hoak, D., Hodge, K. A., Hofman, D., Holt, K., Hopkins, P., Horrom, T., Hoske, D., Hosken, D. J., Hough, J., Euler, S., Howell, E. J., Hu, Y., Huerta, E., Hughey, B., Husa, S., Huttner, S. H., Huynh, M., Huynh-Dinh, T., Idrisy, A., Ingram, D. R., Evenson, P. A., Inta, R., Islas, G., Isogai, T., Ivanov, A., Iyer, B. R., Izumi, K., Jacobson, M., Jang, H., Jaranowski, P., Ji, Y., Fadiran, O., Jiménez-Forteza, F., Johnson, W. W., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., K, Haris, Kalmus, P., Kalogera, V., Kandhasamy, S., Fazely, A. R., Kang, G., Kanner, J. B., Karlen, J., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, H., Kaufer, S., Kaur, T., Kawabe, K., Fedynitch, A., Kawazoe, F., Kéfélian, F., Keiser, G. M., Keitel, D., Kelley, D. B., Kells, W., Keppel, D. G., Khalaidovski, A., Khalili, F. Y., Khazanov, E. A., Anderson, T., Feintzeig, J., Kim, C., Kim, K., Kim, N. G., Kim, N., Kim, S., Kim, Y.-M., King, E. J., King, P. J., Kinzel, D. L., Kissel, J. S., Felde, J., Klimenko, S., Kline, J., Koehlenbeck, S., Kokeyama, K., Kondrashov, V., Koranda, S., Korth, W. Z., Kowalska, I., Kozak, D. B., Kringel, V., Feusels, T., Królak, A., Kuehn, G., Kumar, A., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lam, P. K., Landry, M., Lantz, B., Filimonov, K., Larson, S., Lasky, P. D., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Finley, C., Lee, J., Lee, P. J., Leonardi, M., Leong, J. R., Le Roux, A., Leroy, N., Letendre, N., Levin, Y., Levine, B., Lewis, J., Fischer-Wasels, T., Li, T. G. F., Libbrecht, K., Libson, A., Lin, A. C., Littenberg, T. B., Lockerbie, N. A., Lockett, V., Lodhia, D., Loew, K., Logue, J., Flis, S., Lombardi, A. L., Lopez, E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J., Lubinski, M. J., Lück, H., Lundgren, A. P., Franckowiak, A., Ma, Y., Macdonald, E. P., MacDonald, T., Machenschalk, B., MacInnis, M., Macleod, D. M., Magaña-Sandoval, F., Magee, R., Mageswaran, M., Maglione, C., Frantzen, K., Mailand, K., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Manca, G. M., Mandel, I., Mandic, V., Mangano, V., Mangini, N. M., Fuchs, T., Mansell, G., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A., Maros, E., Marque, J., Martelli, F., Arguelles, C., Gaisser, T. K., Martin, I. W., Martin, R. M., Martinelli, L., Martynov, D., Marx, J. N., Mason, K., Masserot, A., Massinger, T. J., Matichard, F., Matone, L., Gallagher, J., Mavalvala, N., May, G., Mazumder, N., Mazzolo, G., McCarthy, R., McClelland, D. E., McGuire, S. C., McIntyre, G., McIver, J., McLin, K., Gerhardt, L., Meacher, D., Meadors, G. D., Mehmet, M., Meidam, J., Meinders, M., Melatos, A., Mendell, G., Mercer, R. A., Meshkov, S., Messenger, C., Gier, D., Meyer, M. S., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Mikhailov, E. E., Milano, L., Minenkov, Y., Mingarelli, C. M. F., Gladstone, L., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moe, B., Moggi, A., Mohan, M., Mohapatra, S. R. P., Moraru, D., Glüsenkamp, T., Moreno, G., Morgado, N., Morriss, S. R., Mossavi, K., Mours, B., Mow-Lowry, C. M., Mueller, C. L., Mueller, G., Mullavey, A., Munch, J., Golup, G., Murphy, D., Murray, P. G., Mytidis, A., Nagy, M. F., Nardecchia, I., Naticchioni, L., Nayak, R. K., Necula, V., Nelemans, G., Neri, I., Gonzalez, J. G., Neri, M., Newton, G., Nguyen, T., Nielsen, A. B., Nissanke, S., Nitz, A. H., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Goodman, J. A., Ochsner, E., O’Dell, J., Oelker, E., Oh, J. J., Oh, S. H., Ohme, F., Omar, S., Oppermann, P., Oram, R., O’Reilly, B., Góra, D., Ortega, W., O’Shaughnessy, R., Osthelder, C., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Padilla, C., Pai, A., Palashov, O., Arlen, T. C., Grandmont, D. T., Palomba, C., Pan, H., Pan, Y., Pankow, C., Paoletti, F., Papa, M. A., Paris, H., Pasqualetti, A., Passaquieti, R., Passuello, D., Grant, D., Pedraza, M., Pele, A., Penn, S., Perreca, A., Phelps, M., Pichot, M., Pickenpack, M., Piergiovanni, F., Pierro, V., Pinard, L., Gretskov, P., Pinto, I. M., Pitkin, M., Poeld, J., Poggiani, R., Poteomkin, A., Powell, J., Prasad, J., Predoi, V., Premachandra, S., Prestegard, T., Groh, J. C., Price, L. R., Prijatelj, M., Privitera, S., Prodi, G. 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Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Centre National de la Recherche Scientifique (CNRS), ESPCI ParisTech, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Becker Tjus, J., Becker, K. H., Benzvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Bser, S., Botner, O., Brayeur, L., Bretz, H. P., Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Cruz Silva, A. H., Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andr, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., Deyoung, T., Daz Vlez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gra, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Gro, A., Ha, C., Haack, C., Haj Ismail, A., Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kls, J., Klein, S. R., Khne, J. 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M., Favata, M., Fazi, D., Fehrmann, H., Fejer, M. M., Feldbaum, D., Feroz, F., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Finn, L. S., Fiori, I., Fisher, R. P., Flaminio, R., Fournier, J. D., Franco, S., Frasca, S., Frasconi, F., Frede, M., Frei, Z., Freise, A., Frey, R., Fricke, T. T., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gair, J. R., Gammaitoni, L., Gaonkar, S., Garufi, Fabio, Gehrels, N., Gemme, G., Gendre, B., Genin, E., Gennai, A., Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gleason, J., Goetz, E., Goetz, R., Gondan, L., Gonzlez, G., Gordon, N., Gorodetsky, M. L., Gossan, S., Goler, S., Gouaty, R., Grf, C., Graff, P. B., Granata, M., Grant, A., Gras, S., Gray, C., Greenhalgh, R. J. S., Gretarsson, A. M., Groot, P., Grote, H., Grover, K., Grunewald, S., Guidi, G. M., Guido, C. J., Gushwa, K., Gustafson, E. K., Gustafson, R., Ha, J., Hall, E. D., Hamilton, W., Hammer, D., Hammond, G., Hanke, M., Hanks, J., Hanna, C., Hannam, M. D., Hanson, J., Harms, J., Harry, G. M., Harry, I. W., Harstad, E. D., Hart, M., Hartman, M. T., Haster, C. J., Haughian, K., Heidmann, A., Heintze, M., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Heptonstall, A. W., Heurs, M., Hewitson, M., Hild, S., Hoak, D., Hodge, K. A., Hofman, D., Holt, K., Hopkins, P., Horrom, T., Hoske, D., Hosken, D. J., Hough, J., Howell, E. J., Hu, Y., Huerta, E., Hughey, B., Husa, S., Huttner, S. H., Huynh, M., Huynh Dinh, T., Idrisy, A., Ingram, D. R., Inta, R., Islas, G., Isogai, T., Ivanov, A., Iyer, B. R., Izumi, K., Jacobson, M., Jang, H., Jaranowski, P., Ji, Y., Jimnez Forteza, F., Johnson, W. W., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., Haris, K, Kalmus, P., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J. B., Karlen, J., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, H., Kaufer, S., Kaur, T., Kawabe, K., Kawazoe, F., Kflian, F., Keiser, G. M., Keitel, D., Kelley, D. B., Kells, W., Keppel, D. G., Khalaidovski, A., Khalili, F. Y., Khazanov, E. A., Kim, C., Kim, K., Kim, N. G., Kim, N., Kim, S., Kim, Y. M., King, E. J., King, P. J., Kinzel, D. L., Kissel, J. S., Klimenko, S., Kline, J., Koehlenbeck, S., Kokeyama, K., Kondrashov, V., Koranda, S., Korth, W. Z., Kowalska, I., Kozak, D. B., Kringel, V., Krlak, A., Kuehn, G., Kumar, A., Nanda Kumar, D., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lam, P. K., Landry, M., Lantz, B., Larson, S., Lasky, P. D., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Lee, J., Lee, P. J., Leonardi, M., Leong, J. R., Le Roux, A., Leroy, N., Letendre, N., Levin, Y., Levine, B., Lewis, J., T. G. F., Li, Libbrecht, K., Libson, A., Lin, A. C., Littenberg, T. B., Lockerbie, N. A., Lockett, V., Lodhia, D., Loew, K., Logue, J., Lombardi, A. L., Lopez, E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J., Lubinski, M. J., Lck, H., Lundgren, A. P., Ma, Y., Macdonald, E. P., Macdonald, T., Machenschalk, B., Macinnis, M., Macleod, D. M., Magaa Sandoval, F., Magee, R., Mageswaran, M., Maglione, C., Mailand, K., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Manca, G. M., Mandel, I., Mandic, V., Mangano, V., Mangini, N. M., Mansell, G., Mantovani, M., Marchesoni, F., Marion, F., Mrka, S., Mrka, Z., Markosyan, A., Maros, E., Marque, J., Martelli, F., Martin, I. W., Martin, R. M., Martinelli, L., Martynov, D., Marx, J. N., Mason, K., Masserot, A., Massinger, T. J., Matichard, F., Matone, L., Mavalvala, N., May, G., Mazumder, N., Mazzolo, G., Mccarthy, R., Mcclelland, D. E., Mcguire, S. C., Mcintyre, G., Mciver, J., Mclin, K., Meacher, D., Meadors, G. D., Mehmet, M., Meidam, J., Meinders, M., Melatos, A., Mendell, G., Mercer, R. A., Meshkov, S., Messenger, C., Meyer, M. S., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Mikhailov, E. E., Milano, L., Minenkov, Y., Mingarelli, C. M. F., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moe, B., Moggi, A., Mohan, M., Mohapatra, S. R. P., Moraru, D., Moreno, G., Morgado, N., Morriss, S. R., Mossavi, K., Mours, B., Mow Lowry, C. M., Mueller, C. L., Mueller, G., Mukherjee, S., Mullavey, A., Munch, J., Murphy, D., Murray, P. G., Mytidis, A., Nagy, M. F., Nardecchia, I., Naticchioni, L., Nayak, R. K., Necula, V., Nelemans, G., Neri, I., Neri, M., Newton, G., Nguyen, T., Nielsen, A. B., Nissanke, S., Nitz, A. H., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Ochsner, E., Odell, J., Oelker, E., J. J., Oh, S. H., Oh, Ohme, F., Omar, S., Oppermann, P., Oram, R., Oreilly, B., Ortega, W., Oshaughnessy, R., Osthelder, C., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Padilla, C., Pai, A., Palashov, O., Palomba, C., Pan, H., Pan, Y., Pankow, C., Paoletti, F., Papa, M. A., Paris, H., Pasqualetti, A., Passaquieti, R., Passuello, D., Pedraza, M., Pele, A., Penn, S., Perreca, A., Phelps, M., Pichot, M., Pickenpack, M., Piergiovanni, F., Pierro, V., Pinard, L., Pinto, I. M., Pitkin, M., Poeld, J., Poggiani, R., Poteomkin, A., Powell, J., Prasad, J., Predoi, V., Premachandra, S., Prestegard, T., Price, L. R., Prijatelj, M., Privitera, S., Prodi, G. A., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Prrer, M., Qin, J., Quetschke, V., Quintero, E., Quitzow James, R., Raab, F. J., Rabeling, D. S., Rcz, I., Radkins, H., Raffai, P., Raja, S., Rajalakshmi, G., Rakhmanov, M., Ramet, C., Ramirez, K., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Recchia, S., Reed, C. M., Regimbau, T., Reid, S., Reitze, D. H., Reula, O., Rhoades, E., Ricci, F., Riesen, R., Riles, K., Robertson, N. A., Robinet, F., Rocchi, A., Roddy, S. B., Rolland, L., Rollins, J. G., Romano, R., Romanov, G., Romie, J. H., Rosiska, D., Rowan, S., Rdiger, A., Ruggi, P., Ryan, K., Salemi, F., Sammut, L., Sandberg, V., Sanders, J. R., Sankar, S., Sannibale, V., Santiago Prieto, I., Saracco, E., Sassolas, B., Sathyaprakash, B. S., Saulson, P. R., Savage, R., Scheuer, J., Schilling, R., Schilman, M., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schreiber, E., Schuette, D., Schutz, B. F., Scott, J., Scott, S. M., Sellers, D., Sengupta, A. S., Sentenac, D., Sequino, V., Sergeev, A., Shaddock, D. A., Shah, S., Shahriar, M. S., Shaltev, M., Shao, Z., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sidery, T. L., Siellez, K., Siemens, X., Sigg, D., Simakov, D., Singer, A., Singer, L., Singh, R., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., Smith, J. R., Smith, M. R., Smith, R. J. E., Smith Lefebvre, N. D., Son, E. J., Sorazu, B., Souradeep, T., Staley, A., Stebbins, J., Steinke, M., Steinlechner, J., Steinlechner, S., Stephens, B. C., Steplewski, S., Stevenson, S., Stone, R., Stops, D., Strain, K. A., Straniero, N., Strigin, S., Sturani, R., Stuver, A. L., Summerscales, T. Z., Susmithan, S., Sutton, P. J., Swinkels, B., Tacca, M., Talukder, D., Tanner, D. B., Tao, J., Tarabrin, S. P., Taylor, R., Tellez, G., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thorne, K. A., Thorne, K. S., Thrane, E., Tiwari, V., Tokmakov, K. V., Tomlinson, C., Tonelli, M., Torres, C. V., Torrie, C. I., Travasso, F., Traylor, G., Tse, M., Tshilumba, D., Tuennermann, H., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., Vallisneri, M., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., van der Sluys, M. V., van Heijningen, J., van Veggel, A. A., Vass, S., Vasth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Verkindt, D., Vetrano, F., Vicer, A., Vincent Finley, R., Vinet, J. Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vousden, W. D., Vyachanin, S. P., Wade, A. R., Wade, L., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, M., Wang, X., Ward, R. L., Was, M., Weaver, B., Wei, L. W., Weinert, M., Weinstein, A. J., Weiss, R., Welborn, T., Wen, L., Wessels, P., West, M., Westphal, T., Wette, K., Whelan, J. T., White, D. J., Whiting, B. F., Wiesner, K., Wilkinson, C., Williams, K., Williams, L., Williams, R., Williams, T. D., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M., Winkler, W., Wipf, C. C., Wiseman, A. G., Wittel, H., Woan, G., Wolovick, N., Worden, J., Wu, Y., Yablon, J., Yakushin, I., Yam, W., Yamamoto, H., Yancey, C. C., Yang, H., Yvert, M., Zadrony, A., Zanolin, M., Zendri, J. P., Fan, Zhang, Zhang, L., Zhao, C., Zhu, H., Zhu, X. J., Zucker, M. E., Zuraw, S., Zweizig, J., Pinto, Innocenzo, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), The IceCube Collaboration, The LIGO Scientific Collaboration, The Virgo Collaboration, Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Max-Planck-Institut für Kernphysik ( MPIK ), Physique Corpusculaire et Cosmologie - Collège de France ( PCC ), Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Observatoire de Paris-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), APC - Gravitation ( APC-Gravitation ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Max-Planck-Institut-Max-Planck-Institut, Observatoire de la Côte d'Azur ( OCA ), Centre National de la Recherche Scientifique ( CNRS ), RWTH Aachen University, University of Adelaide, University of Alaska Anchorage, Clark-Atlanta University, Georgia Institute of Technology, Southern University, University of California, Lawrence Berkeley National Laboratory, Humboldt-Universität zu Berlin, Ruhr-Universität Bochum, Universität Bonn, Science Faculty, Dienst ELEM, Chiba University, University of Canterbury, University of Maryland, Ohio State University, University of Copenhagen, TU Dortmund University, University of Alberta, Friedrich-Alexander-Universität Erlangen-Nürnberg, Université de Genève, University of Gent, University of Kansas, University of Wisconsin, University of Mainz, Université de Mons, Technische Universität München, University of Delaware, University of Oxford, South Dakota School of Mines and Technology, Stockholm University, Stony Brook University, Sungkyunkwan University, University of Toronto, University of Alabama, Pennsylvania State University, Uppsala University, University of Wuppertal, DESY, California Institute of Technology, Louisiana State University, Università di Salerno, Complesso Universitario di Monte S.Angelo, University of Florida, LIGO Livingston Observatory, Cardiff University, University of Sannio at Benevento, Max-Planck-Institut für Gravitationsphysik, Science Park, Massachusetts Institute of Technology, Instituto Nacional de Pesquisas Espaciais, Tata Institute of Fundamental Research, Syracuse University, University of Wisconsin-Milwaukee, Leibniz Universität Hannover, Università di Siena, Sezione di Pisa, Stanford University, University of Mississippi, California State University Fullerton, Sezione di Roma, University of Birmingham, Montana State University, European Gravitational Observatory (EGO), LIGO Hanford Observatory, University of Glasgow, Sorbonne Paris Cité, Columbia University, Università di Pisa, CAMK-PAN, Astronomical Observatory Warsaw University, Università Degli Studi di Genova, Sezione di Genova, Lomonosov Moscow State University, IN2P3/CNRS, NASA/Goddard Space Flight Center, University of Western Australia, Radboud University Nijmegen, Observatoire de la Côte d'Azur, MTA Atomki, Université de Rennes 1, CNRS/IN2P3, Washington State University, Inter-University Centre for Astronomy and Astrophysics, Sezione di Perugia, Kyoto University, Università Degli Studi di Urbino Carlo Bo, Sezione di Firenze, University of Oregon, Université Pierre et Marie Curie, VU University Amsterdam, University of Massachusetts Amherst, Université de Lyon, Universitat de les Illes Balears, Complesso Universitario di Monte S. Angelo, Tsinghua University, University of Michigan, Sezione di Roma Tor Vergata, National Tsing Hua University, Charles Sturt University, Caltech-CaRT, Pusan National University, Australian National University, Carleton College, Università di Roma Tor Vergata, Gran Sasso Science Institute, Università di Roma 'La Sapienza', University of Brussels, Sonoma State University, George Washington University, University of Cambridge, University of Minnesota, University of Texas at Brownsville, University of Sheffield, RMKI, Argentinian Gravitational Wave Group, Università di Trento, Gruppo Collegato di Trento, Northwestern University, Montclair State University, 'Lendulet' A. R. G., Università di Perugia, HSIC, Embry-Riddle Aeronautical University, Seoul National University, Perimeter Institute for Theoretical Physics, American University, College of William and Mary, Raman Research Institute, Korea Institute of Science and Technology Information, Białystok University, University of Southampton, CET Campus, Institute of Applied Physics, Hanyang University, NCBJ, IM-PAN, Institute for Plasma Research, University of Melbourne, Sezione di Padova, Monash University, University of Strathclyde, Louisiana Tech University, CNRS, Dipartimento di Fisica, AandM College, IISER-Kolkata, National Institute for Mathematical Sciences, Hobart and William Smith Colleges, RRCAT, Tata Institute for Fundamental Research, University of the West of Scotland, Institute of Astronomy, Indian Institute of Technology, Universidade Estadual Paulista (UNESP), Andrews University, Trinity University, University of Washington, Rochester Institute of Technology, Southeastern Louisiana University, Abilene Christian University, Sezione di Napoli, Physics, and Elementary Particle Physics
Subjects: MECHANISM, Physics and Astronomy (miscellaneous), Astrophysics, FOLLOW-UP OBSERVATIONS, ASTROPHYSICAL SOURCES, IceCube, neutrino, Detection of gravitational wave, Gravitational waves, neutrino, Observatory, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], QC, LIGO Scientific Collaboration, QB, Physics, GAMMA-RAY BURSTS, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, ASTRONOMY, Nuclear and High Energy Physics, NEUTRINOS, Neutrino detector, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Neutrino, SENSITIVITY, GIANT FLARE, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], 95.85.Ry, MUON NEUTRINOS, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Cosmology and Extragalactic Astrophysics, ACCELERATION, Gravitational waves, General Relativity and Quantum Cosmology, INSTABILITIES, Settore FIS/05 - Astronomia e Astrofisica, CORE-COLLAPSE SUPERNOVAE, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, SDG 7 - Affordable and Clean Energy, CORE-COLLAPSE, DETECTOR, Gravitational wave, 95.85.Sz, MAGNETIZED NEUTRON-STARS, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astronomy, TRANSIENTS, RELATIVISTIC STARS, LIGO, Physics and Astronomy, [ SDU.ASTR.HE ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Gamma-ray burst, EMISSION, Energy (signal processing)
Abstract: Made available in DSpace on 2022-04-29T07:21:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-11-17 We report the results of a multimessenger search for coincident signals from the LIGO and Virgo gravitational-wave observatories and the partially completed IceCube high-energy neutrino detector, including periods of joint operation between 2007-2010. These include parts of the 2005-2007 run and the 2009-2010 run for LIGO-Virgo, and IceCube's observation periods with 22, 59 and 79 strings. We find no significant coincident events, and use the search results to derive upper limits on the rate of joint sources for a range of source emission parameters. For the optimistic assumption of gravitational-wave emission energy of 10-2M c2 at ∼150Hz with ∼60ms duration, and high-energy neutrino emission of 1051erg comparable to the isotropic gamma-ray energy of gamma-ray bursts, we limit the source rate below 1.6×10-2Mpc-3yr-1. We also examine how combining information from gravitational waves and neutrinos will aid discovery in the advanced gravitational-wave detector era. III. Physikalisches Institut RWTH Aachen University School of Chemistry and Physics University of Adelaide Department of Physics and Astronomy University of Alaska Anchorage, 3211 Providence Drive CTSPS Clark-Atlanta University School of Physics Center for Relativistic Astrophysics Georgia Institute of Technology Department of Physics Southern University Department of Physics University of California Lawrence Berkeley National Laboratory Institut für Physik Humboldt-Universität zu Berlin Fakultät für Physik and Astronomie Ruhr-Universität Bochum Physikalisches Institut Universität Bonn, Nussallee 12 Université Libre de Bruxelles Science Faculty, CP230 Vrije Universiteit Brussel Dienst ELEM Department of Physics Chiba University Department of Physics and Astronomy University of Canterbury, Private Bag 4800 Department of Physics University of Maryland Department of Physics Center for Cosmology and Astro-Particle Physics Ohio State University Department of Astronomy Ohio State University Niels Bohr Institute University of Copenhagen Department of Physics TU Dortmund University Department of Physics University of Alberta Erlangen Centre for Astroparticle Physics Friedrich-Alexander-Universität Erlangen-Nürnberg Département de Physique Nucléaire et Corpusculaire Université de Genève Department of Physics and Astronomy University of Gent Department of Physics and Astronomy University of California Department of Physics and Astronomy University of Kansas Department of Astronomy University of Wisconsin Department of Physics Wisconsin IceCube Particle Astrophysics Center University of Wisconsin Institute of Physics University of Mainz, Staudinger Weg 7 Université de Mons Technische Universität München Bartol Research Institute Department of Physics and Astronomy University of Delaware Department of Physics University of Oxford, 1 Keble Road Physics Department South Dakota School of Mines and Technology Department of Physics University of Wisconsin Oskar Klein Centre Department of Physics Stockholm University Department of Physics and Astronomy Stony Brook University Department of Physics Sungkyunkwan University Department of Physics University of Toronto Department of Physics and Astronomy University of Alabama Department of Astronomy and Astrophysics Pennsylvania State University Department of Physics Pennsylvania State University Department of Physics and Astronomy Uppsala University, Box 516 Department of Physics University of Wuppertal DESY LIGO California Institute of Technology Louisiana State University Università di Salerno INFN Sezione di Napoli Complesso Universitario di Monte S.Angelo University of Florida LIGO Livingston Observatory Cardiff University University of Sannio at Benevento Albert-Einstein-Institut Max-Planck-Institut für Gravitationsphysik Nikhef Science Park LIGO Massachusetts Institute of Technology Instituto Nacional de Pesquisas Espaciais International Centre for Theoretical Sciences Tata Institute of Fundamental Research Syracuse University University of Wisconsin-Milwaukee Leibniz Universität Hannover Università di Siena INFN Sezione di Pisa Stanford University University of Mississippi California State University Fullerton INFN Sezione di Roma University of Birmingham Montana State University European Gravitational Observatory (EGO) LIGO Hanford Observatory SUPA University of Glasgow APC AstroParticule et Cosmologie Sorbonne Paris Cité, 10, rue Alice Domon et Léonie Duquet Columbia University Università di Pisa CAMK-PAN Astronomical Observatory Warsaw University Università Degli Studi di Genova INFN Sezione di Genova Faculty of Physics Lomonosov Moscow State University LAL Université Paris-Sud IN2P3/CNRS NASA/Goddard Space Flight Center University of Western Australia Department of Astrophysics/IMAPP Radboud University Nijmegen, P.O. Box 9010 Université Nice-Sophia-Antipolis CNRS Observatoire de la Côte d'Azur MTA Atomki Institut de Physique de Rennes CNRS Université de Rennes 1 Laboratoire d'Annecy-le-Vieux de Physique des Particules (LAPP) Université de Savoie CNRS/IN2P3 Washington State University Inter-University Centre for Astronomy and Astrophysics INFN Sezione di Perugia Yukawa Institute for Theoretical Physics Kyoto University Università Degli Studi di Urbino Carlo Bo INFN Sezione di Firenze University of Oregon Laboratoire Kastler Brossel ENS Université Pierre et Marie Curie VU University Amsterdam University of Maryland University of Massachusetts Amherst Laboratoire des Matériaux Avancés (LMA) IN2P3/CNRS Université de Lyon Universitat de les Illes Balears Università di Napoli 'Federico II' Complesso Universitario di Monte S. Angelo Canadian Institute for Theoretical Astrophysics University of Toronto Tsinghua University University of Michigan INFN Sezione di Roma Tor Vergata National Tsing Hua University Charles Sturt University Caltech-CaRT Pusan National University Australian National University Carleton College Università di Roma Tor Vergata INFN Gran Sasso Science Institute Università di Roma 'La Sapienza' University of Brussels Sonoma State University George Washington University University of Cambridge University of Minnesota University of Texas at Brownsville University of Sheffield Wigner RCP RMKI, Konkoly Thege Miklós út 29-33 Argentinian Gravitational Wave Group Università di Trento INFN Gruppo Collegato di Trento Northwestern University Montclair State University Pennsylvania State University MTA Eötvös University 'Lendulet' A. R. G. Università di Perugia Rutherford Appleton Laboratory HSIC Embry-Riddle Aeronautical University Seoul National University Perimeter Institute for Theoretical Physics American University College of William and Mary University of Adelaide Raman Research Institute Korea Institute of Science and Technology Information Białystok University University of Southampton IISER-TVM CET Campus Institute of Applied Physics Hanyang University NCBJ IM-PAN Institute for Plasma Research University of Melbourne INFN Sezione di Padova Monash University SUPA University of Strathclyde Louisiana Tech University ESPCI CNRS Università di Camerino Dipartimento di Fisica Southern University AandM College IISER-Kolkata National Institute for Mathematical Sciences Hobart and William Smith Colleges RRCAT Tata Institute for Fundamental Research SUPA University of the West of Scotland Institute of Astronomy Indian Institute of Technology Instituto de Física Teórica Universidade Estadual Paulista ICTP South American Institute for Fundamental Research Andrews University Trinity University University of Washington Rochester Institute of Technology Southeastern Louisiana University Abilene Christian University INFN Sezione di Napoli Instituto de Física Teórica Universidade Estadual Paulista ICTP South American Institute for Fundamental Research
Published: 2014

35. A REST model for high throughput scheduling in computational grids

Author: Stokes-Rees, I, Stokes-Rees, Ian, McArthur, I, and McKeever, S
Subjects: Particle physics, Scalable systems, Computer science (mathematics)
Abstract: Current grid computing architectures have been based on cluster management and batch queuing systems, extended to a distributed, federated domain. These have shown shortcomings in terms of scalability, stability, and modularity. To address these problems, this dissertation applies architectural styles from the Internet and Web to the domain of generic computational grids. Using the REST style, a flexible model for grid resource interaction is developed which removes the need for any centralised services or specific protocols, thereby allowing a range of implementations and layering of further functionality. The context for resource interaction is a generalisation and formalisation of the Condor ClassAd match-making mechanism. This set theoretic model is described in depth, including the advantages and features which it realises. This RESTful style is also motivated by operational experience with existing grid infrastructures, and the design, operation, and performance of a proto-RESTful grid middleware package named DIRAC. This package was designed to provide for the LHCb particle physics experiment’s “off-line” computational infrastructure, and was first exercised during a 6 month data challenge which utilised over 670 years of CPU time and produced 98 TB of data through 300,000 tasks executed at computing centres around the world. The design of DIRAC and performance measures from the data challenge are reported. The main contribution of this work is the development of a REST model for grid resource interaction. In particular, it allows resource templating for scheduling queues which provide a novel distributed and scalable approach to resource scheduling on the grid.
Published: 2016

36. Flavor Ratio of Astrophysical Neutrinos above 35 TeV in IceCube

Author: IceCube Collaboration, Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Böser, S., Botner, O., Brayeur, L., Bretz, H. -P., Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dumm, J. P., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Góra, D., Grant, D., Gretskov, P., Groh, J. C., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Köhne, J. -H., Kohnen, G., Kolanoski, H., Koob, A., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Lünemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Ö., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Rädel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G., Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strahler, E. A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tamburro, A., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zoll, M., Physics, and Elementary Particle Physics
Subjects: FLUX, AMANDA, Particle physics, Physics::Instrumentation and Detectors, ENERGIES, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, General Physics and Astronomy, Flux, Cosmic ray, Astrophysics, ACCELERATION, 01 natural sciences, flavor : ratio, High Energy Physics - Experiment, IceCube Neutrino Observatory, IceCube, High Energy Physics - Experiment (hep-ex), Pion, Observatory, 0103 physical sciences, ddc:550, 010306 general physics, Neutrino oscillation, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Sigma, showers, COSMIC-RAYS, atmosphere : background, tracks, neutrino : flavor : ratio, neutrino : oscillation, flux, observatory, Physics and Astronomy, 13. Climate action, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, neutrino : VHE, pi : decay
Abstract: A diffuse flux of astrophysical neutrinos above $100\,\mathrm{TeV}$ has been observed at the IceCube Neutrino Observatory. Here we extend this analysis to probe the astrophysical flux down to $35\,\mathrm{TeV}$ and analyze its flavor composition by classifying events as showers or tracks. Taking advantage of lower atmospheric backgrounds for shower-like events, we obtain a shower-biased sample containing 129 showers and 8 tracks collected in three years from 2010 to 2013. We demonstrate consistency with the $(f_e:f_{\mu}:f_\tau)_\oplus\approx(1:1:1)_\oplus$ flavor ratio at Earth commonly expected from the averaged oscillations of neutrinos produced by pion decay in distant astrophysical sources. Limits are placed on non-standard flavor compositions that cannot be produced by averaged neutrino oscillations but could arise in exotic physics scenarios. A maximally track-like composition of $(0:1:0)_\oplus$ is excluded at $3.3\sigma$, and a purely shower-like composition of $(1:0:0)_\oplus$ is excluded at $2.3\sigma$., Comment: 8 pages, 3 figures. Submitted to PRL
Published: 2016

37. Where does the money go? Financialised chains and the crisis in adult residential care

Author: Burns, D., Cowie, L., Earle, J., Folkman, P., Hyde, P., Johal, P., Jones Rees, I., Killett, A., and Williams, K.
Published: 2016

38. Hepatitis C: year 1 real life results from the All Wales hepatitis C roll out programme

Author: Samuel, D., primary, Alcolado, R., additional, Czajkowski, M., additional, Reeve, N., additional, Rees, I., additional, Hams, P., additional, Hardcastle, G., additional, Mitchell, K., additional, Gale, R., additional, Andrew, A., additional, Ball, B., additional, Ch’ng, C.L., additional, Tomkinson, D., additional, Blinston, D., additional, Davies, A., additional, Ryan, H., additional, Mathialahan, T., additional, Nicholas, S., additional, Alexander, E., additional, Mapp, L., additional, Walsh, S., additional, Rockey, K., additional, Rees, J., additional, Ahmed, W., additional, Thompson, A., additional, Sutton, C., additional, Grenier, T., additional, Kneath, S., additional, Johnson, L., additional, Edwards, H., additional, Sitta, O., additional, Jones, T., additional, and Healy, B., additional
Published: 2017
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39. The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis

Author: Carbone, M, Sharp, S, Flack, S, Paximadas, D, Spiess, K, Adgey, C, Griffiths, L, Lim, R, Trembling, P, Williamson, K, Wareham, N, Aldersley, M, Bathgate, A, Burroughs, A, Heneghan, M, Neuberger, J, Thorburn, D, Hirschfield, G, Cordell, H, Alexander, G, Jones, D, Sandford, R, Mells, G, Kirby, J, Taylor Robinson, S, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Williams, S, Grellier, L, Banim, P, Chilton, A, Curtis, H, Gess, M, Drake, I, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Marshall, E, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Das, D, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Null, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, Denise O'Donnell, N, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, Lynn O'Donohoe, N, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordul, J, CARBONE, MARCO, Kordul, J., Carbone, M, Sharp, S, Flack, S, Paximadas, D, Spiess, K, Adgey, C, Griffiths, L, Lim, R, Trembling, P, Williamson, K, Wareham, N, Aldersley, M, Bathgate, A, Burroughs, A, Heneghan, M, Neuberger, J, Thorburn, D, Hirschfield, G, Cordell, H, Alexander, G, Jones, D, Sandford, R, Mells, G, Kirby, J, Taylor Robinson, S, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Williams, S, Grellier, L, Banim, P, Chilton, A, Curtis, H, Gess, M, Drake, I, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Marshall, E, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Das, D, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Null, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, Denise O'Donnell, N, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, Lynn O'Donohoe, N, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordul, J, CARBONE, MARCO, and Kordul, J.
Abstract: The biochemical response to ursodeoxycholic acid (UDCA)-so-called "treatment response"-strongly predicts long-term outcome in primary biliary cholangitis (PBC). Several long-term prognostic models based solely on the treatment response have been developed that are widely used to risk stratify PBC patients and guide their management. However, they do not take other prognostic variables into account, such as the stage of the liver disease. We sought to improve existing long-term prognostic models of PBC using data from the UK-PBC Research Cohort. We performed Cox's proportional hazards regression analysis of diverse explanatory variables in a derivation cohort of 1,916 UDCA-treated participants. We used nonautomatic backward selection to derive the best-fitting Cox model, from which we derived a multivariable fractional polynomial model. We combined linear predictors and baseline survivor functions in equations to score the risk of a liver transplant or liver-related death occurring within 5, 10, or 15 years. We validated these risk scores in an independent cohort of 1,249 UDCA-treated participants. The best-fitting model consisted of the baseline albumin and platelet count, as well as the bilirubin, transaminases, and alkaline phosphatase, after 12 months of UDCA. In the validation cohort, the 5-, 10-, and 15-year risk scores were highly accurate (areas under the curve: >0.90). Conclusions: The prognosis of PBC patients can be accurately evaluated using the UK-PBC risk scores. They may be used to identify high-risk patients for closer monitoring and second-line therapies, as well as low-risk patients who could potentially be followed up in primary care.
Published: 2016

40. The LHCb Detector at the LHC

Author: Alves, A, Andrade, L, Barbosa, A, Bediaga, I, Cernicchiaro, G, Guerrer, G, Lima, H, Machado, A, Magnin, J, Marujo, F, De Miranda, J, Reis, A, Santos, A, Toledo, A, Akiba, K, Amato, S, De Paula, B, De Paula, L, Da Silva, T, Gandelman, M, Lopes, J, Marechal, B, Moraes, D, Polycarpo, E, Rodrigues, F, Ballansat, J, Bastian, Y, Boget, D, De Bonis, I, Coco, V, David, P, Decamp, D, Delebecque, P, Drancourt, C, Dumont Dayot, N, Girard, C, Lieunard, B, Minard, M, Pietrzyk, B, Rambure, T, Rospabe, G, T'jampens, S, Ajaltouni, Z, Bohner, G, Bonnefoy, R, Borras, D, Carloganu, C, Chanal, H, Conte, E, Cornat, R, Crouau, M, Delage, E, Deschamps, O, Henrard, P, Jacquet, P, Lacan, C, Laubser, J, Lecoq, J, Lefvre, R, Magne, M, Martemiyanov, M, Mercier, M, Monteil, S, Niess, V, Perret, P, Reinmuth, G, Robert, A, Suchorski, S, Arnaud, K, Aslanides, E, Babel, J, Benchouk, C, Cachemiche, J, Cogan, J, Derue, F, Dinkespiler, B, Duval, P, Garonne, V, Favard, S, Le Gac, R, Leon, F, Leroy, O, Liotard, P, Marin, F, Menouni, M, Ollive, P, Poss, S, Roche, A, Sapunov, M, Tocco, L, Viaud, B, Tsaregorodtsev, A, Amhis, Y, Barrand, G, Barsuk, S, Beigbeder, C, Beneyton, R, Breton, D, Callot, O, Charlet, D, Ds'almagne, B, Duarte, O, Fulda Quenzer, F, Jacholkowska, A, Jean Marie, B, Lefrancois, J, Machefert, F, Robbe, P, Schune, M, Tocut, V, Videau, I, Benayoun, M, Del Buono, L, Gilles, G, Domke, M, Futterschneider, H, Ilgner, C, Kapusta, P, Kolander, M, Krause, R, Lieng, M, Nedos, M, Rudloff, K, Schleich, S, Schwierz, R, Spaan, B, Wacker, K, Warda, K, Agari, M, Bauer, C, Baumeister, D, Bulian, N, Fuchs, H, Fallot Burghardt, W, Glebe, T, Hofmann, W, Knopfle, K, Lochner, S, Ludwig, A, Maciuc, F, Nieto, F, Schmelling, M, Schwingenheuer, B, Sexauer, E, Smale, N, Trunk, U, Voss, H, Albrecht, J, Bachmann, S, Blouw, J, Deissenroth, M, Deppe, H, Dreis, H, Eisele, F, Haas, T, Hansmann Menzemer, S, Hennenberger, S, Knopf, J, Moch, M, Perieanu, A, Rabenecker, S, Rausch, A, Rummel, C, Rusnyak, R, Schiller, M, Stange, U, Uwer, U, Walter, M, Ziegler, R, Avoni, G, Balbi, G, Bonifazi, F, Bortolotti, D, Carbone, A, D'antone, I, Galli, D, Gregori, D, Lax, I, Marconi, U, Peco, G, Vagnoni, V, Valenti, G, Vecchi, S, Bonivento, W, Cardini, A, Cadeddu, S, Deleo, V, Deplano, C, Furcas, S, Lai, A, Oldeman, R, Raspino, D, Saitta, B, Serra, N, Baldini, W, Brusa, S, Chiozzi, S, Ramusino, A, Evangelisti, F, Franconieri, A, Germani, S, Gianoli, A, Guoming, L, Landi, L, Malaguti, R, Padoan, C, Pennini, C, Savrie, M, Squerzanti, S, Zhao, T, Zhu, M, Bizzeti, A, Graziani, G, Lenti, M, Lenzi, M, Maletta, F, Pennazzi, S, Passaleva, G, Veltri, M, Alfonsi, M, Anelli, M, Balla, A, Battisti, A, Bencivenni, G, Campana, P, Carletti, M, Ciambrone, P, Corradi, G, Dane, E, Divirgilio, A, Desimone, P, Felici, G, Forti, C, Gatta, M, Lanfranchi, G, Murtas, F, Pistilli, M, Lener, M, Rosellini, R, Santoni, M, Saputi, A, Sarti, A, Sciubba, A, Zossi, A, Ameri, M, Cuneo, S, Fontanelli, F, Gracco, V, Mini, G, Parodi, M, Petrolini, A, Sannino, M, Vinci, A, Alemi, M, Arnaboldi, C, Bellunato, T, Chignoli, F, De Lucia, A, Galotta, G, Mazza, R, Matteuzzi, C, Musy, M, Negri, P, Perego, D, Pessina, G, Auriemma, G, Bocci, V, Buccheri, A, Chiodi, G, Di Marco, S, Iacoangeli, F, Martellotti, G, Nobrega, R, Pelosi, A, Penso, G, Pinci, D, Rinaldi, W, Rossi, A, Santacesaria, R, Satriano, C, Carboni, G, Iannilli, M, Rodrigues, A, Messi, R, Paoluzzi, G, Sabatino, G, Santovetti, E, Satta, A, Amoraal, J, Van Apeldoorn, G, Arink, R, Van Bakel, N, Band, H, Bauer, T, Berkien, A, Van Beuzekom, M, Bos, E, Bron, C, Ceelie, L, Doets, M, Van Der Eijk, R, Fransen, J, De Groen, P, Gromov, V, Hierck, R, Homma, J, Hommels, B, Hoogland, W, Jans, E, Jansen, F, Jansen, L, Jaspers, M, Kaan, B, Koene, B, Koopstra, J, Kroes, F, Kraan, M, Langedijk, J, Merk, M, Mos, S, Munneke, B, Palacios, J, Papadclis, A, Pellegrino, A, Van Petten, O, Du Pree, T, Roeland, E, Ruckstuhl, W, Schimmel, A, Schuijlenburg, H, Sluijk, T, Spelt, J, Stolte, J, Terrier, H, Tuning, N, Van Lysebetten, A, Vankov, P, Verkooijen, J, Verlaat, B, Vink, W, De Vries, H, Wiggers, L, Smit, G, Zaitsev, N, Zupan, M, Zwart, A, Van Den Brand, J, Bulten, H, De Jong, M, Ketel, T, Klous, S, Kos, J, M'charek, B, Mul, F, Raven, G, Simioni, E, Cheng, J, Dai, G, Deng, Z, Gao, Y, Gong, G, Gong, H, He, J, Hou, L, Li, J, Qian, W, Shao, B, Xue, T, Yang, Z, Zeng, M, Muryn, B, Ciba, K, Oblakowska Mucha, A, Blocki, J, Galuszka, K, Hajduk, L, Michalowski, J, Natkaniec, Z, Polok, G, Stodulski, M, Witek, M, Brzozowski, K, Chlopik, A, Gawor, P, Guzik, Z, Nawrot, A, Srednicki, A, Syryczynski, K, Szczekowski, M, Anghel, D, Cimpean, A, Coca, C, Constantin, F, Cristian, P, Dumitru, D, Giolu, G, Kusko, C, Magureanu, C, Mihon, G, Orlandea, M, Pavel, C, Petrescu, R, Popescu, S, Preda, T, Rosca, A, Rusu, V, Stoica, R, Stoica, S, Tarta, P, Filippov, S, Gavrilov, Y, Golyshkin, L, Gushchin, E, Karavichev, O, Klubakov, V, Kravchuk, L, Kutuzov, V, Laptev, S, Popov, S, Aref'ev, A, 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Vidal Sitjes, G, Websdale, D, Affolder, A, Anderson, J, Biagi, S, Bowcock, T, Carroll, J, Casse, G, Cooke, P, Donleavy, S, Dwyer, L, Hennessy, K, Huse, T, Hutchcroft, D, Jones, D, Lockwood, M, Mccubbin, M, Mcnulty, R, Muskett, D, Noor, A, Patel, G, Rinnert, K, Shears, T, Smith, N, Southern, G, Stavitski, I, Sutcliffe, P, Tobin, M, Traynor, S, Turner, P, Whitley, M, Wormald, M, Wright, V, Bibby, J, Brisbane, S, Brock, M, Charles, M, Ciolfi, C, Gligorov, V, Handford, T, Harnew, N, Harris, F, John, M, Jones, M, Libby, J, Martin, L, Mcarthur, I, Muresan, R, Newby, C, Ottewell, B, Powell, A, Rotolo, N, Senanayake, R, Somerville, L, Soroko, A, Spradlin, P, Sullivan, P, Stokes Rees, I, Topp Jorgensen, S, Xing, F, Wilkinson, G, Artuso, M, Belyaev, I, Blusk, S, Lefeuvre, G, Menaa, N, Menaa Sia, R, Mountain, R, Skwarnicki, T, Stone, S, Wang, J, Abadie, L, Aglieri Rinella, G, Albrecht, E, Andre, J, Anelli, G, Arnaud, N, Augustinus, A, Bal, F, Pazos, M, Barczyk, A, Bargiotti, M, Behrendt, O, Berni, S, Binko, P, Bobillier, V, Braem, A, Brarda, L, Buytaert, J, Camilleri, L, Cambpell, M, Castellani, G, Cataneo, F, Cattaneo, M, Chadaj, B, Charpentier, P, Cherukuwadal, S, Chesi, E, Christiansen, J, Chytracek, R, Clemencic, M, Closier, J, Collins, P, Colrain, P, Cooke, O, Corajod, B, Corti, G, D'Ambrosio, C, Damodaranl, B, David, C, De Capua, S, Decreuse, G, Degaudenzi, H, Dijkstra, H, Droulez, J, Ramos, D, Dufey, J, Dumps, R, Eckstein, D, Ferro Luzzi, M, Fiedler, F, Filthaut, F, Flegel, W, Forty, R, Fournier, C, Frank, M, Frei, C, Gaidioz, B, Gaspar, C, Gayde, J, Gavillet, P, Go, A, Abril, G, Graulich, J, Giudici, P, Elias, A, Guglielmini, P, Gys, T, Hahn, F, Haider, S, Harvey, J, Hay, B, Morata, J, Alvarez, J, Van Herwijnen, E, Hilke, H, Von Holtey, G, Hulsbergen, W, Jacobsson, R, Jamet, O, Joram, C, Jost, B, Kanaya, N, Refolio, J, Koestner, S, Koratzinos, M, Kristic, R, Lacarrere, D, Lasseur, C, Lastovicka, T, Laub, M, Liko, D, Lippmann, C, Lindner, R, Losasso, M, Maier, A, Mair, K, Maley, P, Vila, P, Moine, G, Morant, J, Moritz, M, Moscicki, J, Muecke, M, Mueller, H, Nakada, T, Neufeld, N, Ocariz, J, Aranda, C, Parzefall, U, Patel, M, Pepe Altarelli, M, Piedigrossi, D, Pivk, M, Pokorski, W, Ponce, S, Ranjard, F, Riegler, W, Renaud, J, Roiser, S, Roy, L, Ruf, T, Ruffinoni, D, Saladino, S, Varela, A, Santinelli, R, Schmelling, S, Schmidt, B, Schneider, T, Schoning, A, Schopper, A, Seguinot, J, Snoeys, W, Smith, A, Somogyi, P, Stoical, R, Tejessy, W, Teubert, F, Thomas, E, Alarcon, J, Ullaland, O, Valassi, A, Vannerem, P, Veness, R, Wicht, P, Wiedner, D, Witzeling, W, Wright, A, Wyllie, K, Ypsilantis, T, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), LHCb, Theoretical Physics, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, and Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular
Subjects: visible and IR photons, PROTOTYPE, Physics::Instrumentation and Detectors, Hadron, Large detector systems for particle and astroparticle physics, Particle tracking detectors, Gaseous detectors, Calorimeters, Cherenkov detectors, Particle identification methods, Photon detectors for UV, Detector alignment and calibration methods, Detector cooling and thermo-stabilization, Detector design and construction technologies and materials, 7. Clean energy, 01 natural sciences, Settore FIS/04 - Fisica Nucleare e Subnucleare, Detectors and Experimental Techniques, Nuclear Experiment, Instrumentation, Mathematical Physics, Physics, GEM, Large Hadron Collider, Detector, CP violation, MWPCS, Particle physics, calorimeters, cherenkov detectors, detector alignment and calibration methods, detector cooling and thermo-stabilization, detector design and construction technologies and materials, gaseous detectors, large detector systems for particle and astroparticle physics, particle identification methods, particle tracking detectors, photon detectors for uv, visible and ir photons, NO, Nuclear physics, TECNOLOGIA ELECTRONICA, Photon detectors for UV, visible and IR photons, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], SILICON, 010306 general physics, READ-OUT, 010308 nuclear & particles physics, Particle Physics Detector, High Energy Physics::Phenomenology, AEROGEL, PERFORMANCE, Large detector systems for particle and astroparticle physics, Particle tracking detectors, Gaseous detectors, Calorimeters, Cherenkov detectors, Particle identification methods, Photon detectors for UV, visible and IR photons, Detector alignment and calibration methods, Detector cooling and thermo-stabilization, Detector design and construction technologies and materials, Test beam, OPERATION, Physics::Accelerator Physics, High Energy Physics::Experiment, MUON CHAMBERS, SYSTEM
Abstract: Large detector systems for particle and astroparticle physics; Particle tracking detectors; Gaseous detectors; Calorimeters; Cherenkov detectors; Particle identification methods; Photon detectors for UV. visible and IR photons; Detector alignment and calibration methods; Detector cooling and thermo-stabilization; Detector design and construction technologies and materials. The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems. as established by test beam measurements and simulation studies. is described. © 2008 IOP Publishing Ltd and SISSA.
Published: 2008

41. Atmospheric and astrophysical neutrinos above 1 TeV interacting in IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., De Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., De Vries, K. D., De With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, OE., Pepper, J. A., Heros, Carlos Perez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Elisabeth, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., De Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., De Vries, K. D., De With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, OE., Pepper, J. A., Heros, Carlos Perez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Elisabeth, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Abstract: The IceCube Neutrino Observatory was designed primarily to search for high-energy (TeV-PeV) neutLrinos produced in distant astrophysical objects. A search for. greater than or similar to 100 TeV neutrinos interacting inside the instrumented volume has recently provided evidence for an isotropic flux of such neutrinos. At lower energies, IceCube collects large numbers of neutrinos from the weak decays of mesons in cosmic-ray air showers. Here we present the results of a search for neutrino interactions inside IceCube's instrumented volume between 1 TeV and 1 PeV in 641 days of data taken from 2010-2012, lowering the energy threshold for neutrinos from the southern sky below 10 TeV for the first time, far below the threshold of the previous high-energy analysis. Astrophysical neutrinos remain the dominant component in the southern sky down to a deposited energy of 10 TeV. From these data we derive new constraints on the diffuse astrophysical neutrino spectrum, Phi(v) = 2.06(-0.3)(+0.4) x 10(-18) (E-v = 10(5) GeV)-2.46 +/- 0.12GeV-1 cm(-2) sr(-1) s(-1) for 25 TeV < E-v < 1.4 PeV, as well as the strongest upper limit yet on the flux of neutrinos from charmed-meson decay in the atmosphere, 1.52 times the benchmark theoretical prediction used in previous IceCube results at 90% confidence.
Published: 2015
Full Text: View/download PDF

42. Flavor Ratio of Astrophysical Neutrinos above 35 TeV in IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Boeser, D., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., De Young, T., Diaz-Velez, J. C., Dumm, J. P., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glueenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Kohne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, O., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Radel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Elisabeth, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Boeser, D., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., De Young, T., Diaz-Velez, J. C., Dumm, J. P., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glueenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Kohne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, O., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Radel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Elisabeth, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vanheule, S., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Abstract: A diffuse flux of astrophysical neutrinos above 100 TeV has been observed at the IceCube Neutrino Observatory. Here we extend this analysis to probe the astrophysical flux down to 35 TeV and analyze its flavor composition by classifying events as showers or tracks. Taking advantage of lower atmospheric backgrounds for showerlike events, we obtain a shower-biased sample containing 129 showers and 8 tracks collected in three years from 2010 to 2013. We demonstrate consistency with the (f(e) : f(mu) : f(tau))(circle plus) approximate to (1 : 1 : 1)(circle plus) flavor ratio at Earth commonly expected from the averaged oscillations of neutrinos produced by pion decay in distant astrophysical sources. Limits are placed on nonstandard flavor compositions that cannot be produced by averaged neutrino oscillations but could arise in exotic physics scenarios. A maximally tracklike composition of (0 : 1 : 0)(circle plus) is excluded at 3.3 sigma, and a purely showerlike composition of (1 : 0 : 0)(circle plus) is excluded at 2.3 sigma.
Published: 2015
Full Text: View/download PDF

43. Multipole analysis of IceCube data to search for dark matter accumulated in the Galactic halo

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Macias, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., Heros, Carlos Perez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schnoewald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Macias, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., Heros, Carlos Perez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schnoewald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Abstract: Dark matter which is bound in the Galactic halo might self-annihilate and produce a flux of stable final state particles, e. g. high energy neutrinos. These neutrinos can be detected with IceCube, a cubic-kilometer sized Cherenkov detector. Given IceCube's large field of view, a characteristic anisotropy of the additional neutrino flux is expected. In this paper we describe a multipole method to search for such a large-scale anisotropy in IceCube data. This method uses the expansion coefficients of a multipole expansion of neutrino arrival directions and incorporates signal-specific weights for each expansion coefficient. We apply the technique to a high-purity muon neutrino sample from the Northern Hemisphere. The final result is compatible with the null-hypothesis. As no signal was observed, we present limits on the self-annihilation cross-section averaged over the relative velocity distribution down to 1.9x10(-23) cm(3) s(-1) for a dark matter particle mass of 700-1,000 GeV and direct annihilation into nu(nu) over bar. The resulting exclusion limits come close to exclusion limits from gamma-ray experiments, that focus on the outer Galactic halo, for high dark matter masses of a few TeV and hard annihilation channels.
Published: 2015
Full Text: View/download PDF

44. Search for Prompt Neutrino Emission from Gamma-Ray Bursts with IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Valez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penke, O., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Eva, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Valez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Ishihara, A., Jacobi, E., Jacobsen, J., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penke, O., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Eva, Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., and Zoll, M.
Abstract: We present constraints derived from a search of four years of IceCube data for a prompt neutrino flux from gammaray bursts (GRBs). A single low-significance neutrino, compatible with the atmospheric neutrino background, was found in coincidence with one of the 506 observed bursts. Although GRBs have been proposed as candidate sources for ultra-high-energy cosmic rays, our limits on the neutrino flux disfavor much of the parameter space for the latest models. We also find that no more than similar to 1% of the recently observed astrophysical neutrino flux consists of prompt emission from GRBs that are potentially observable by existing satellites.
Published: 2015
Full Text: View/download PDF

45. Development of a general analysis and unfolding scheme and its application to measure the energy spectrum of atmospheric neutrinos with IceCube

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., De Andre, J. P. A. M., DeClercq, C., De Ridder, S., Desiati, P., De Vries, K. D., Dewith, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glusenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gro, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. H., Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., Perez De Los Heros, Carlos, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Eva, Usner, M., Vallecorsa, S., Van Eijndhoven, N., Vandenbroucke, J., Van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Morik, K., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. P., Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., De Andre, J. P. A. M., DeClercq, C., De Ridder, S., Desiati, P., De Vries, K. D., Dewith, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Glusenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gro, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. H., Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., Perez De Los Heros, Carlos, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, Eva, Usner, M., Vallecorsa, S., Van Eijndhoven, N., Vandenbroucke, J., Van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., and Morik, K.
Abstract: We present the development and application of a generic analysis scheme for the measurement of neutrino spectra with the IceCube detector. This scheme is based on regularized unfolding, preceded by an event selection which uses a Minimum Redundancy Maximum Relevance algorithm to select the relevant variables and a random forest for the classification of events. The analysis has been developed using IceCube data from the 59-string configuration of the detector. 27,771 neutrino candidates were detected in 346 days of livetime. A rejection of 99.9999 % of the atmospheric muon background is achieved. The energy spectrum of the atmospheric neutrino flux is obtained using the TRUEE unfolding program. The unfolded spectrum of atmospheric muon neutrinos covers an energy range from 100 GeV to 1 PeV. Compared to the previous measurement using the detector in the 40-string configuration, the analysis presented here, extends the upper end of the atmospheric neutrino spectrum by more than a factor of two, reaching an energy region that has not been previously accessed by spectral measurements.
Published: 2015
Full Text: View/download PDF

46. Determining neutrino oscillation parameters from atmospheric muon neutrino disappearance with three years of IceCube DeepCore data

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Brunner, J., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., De Young, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Brunner, J., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., De Young, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Abstract: We present a measurement of neutrino oscillations via atmospheric muon neutrino disappearance with three years of data of the completed IceCube neutrino detector. DeepCore, a region of denser IceCube instrumentation, enables the detection and reconstruction of atmospheric muon neutrinos between 10 and 100 GeV, where a strong disappearance signal is expected. The IceCube detector volume surrounding DeepCore is used as a veto region to suppress the atmospheric muon background. Neutrino events are selected where the detected Cherenkov photons of the secondary particles minimally scatter, and the neutrino energy and arrival direction are reconstructed. Both variables are used to obtain the neutrino oscillation parameters from the data, with the best fit given by Delta m(32)(2) = 2.72(-0.20)(+0.19) x 10(-3) eV(2) and sin(2)theta(23) = 0.53(-0.12)(+0.09) (normal mass ordering assumed). The results are compatible, and comparable in precision, to those of dedicated oscillation experiments.
Published: 2015
Full Text: View/download PDF

47. Searches for small-scale anisotropies from neutrino point sources with three years of IceCube data

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Cleverinann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, Jp., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Cleverinann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, Oe., Pepper, J. A., de los Heros, Carlos Perez, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, Jp., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Abstract: Recently, IceCube found evidence for a diffuse signal of astrophysical neutrinos in an energy range of similar to 60 TeV to the PeV-scale [1]. The origin of those events, being a key to understanding the origin of cosmic rays, is still an unsolved question. So far, analyses have not succeeded to resolve the diffuse signal into point-like sources. Searches including a maximum-likelihood-ratio test, based on the reconstructed directions and energies of the detected down- and up-going neutrino candidates, were also performed on IceCube data leading to the exclusion of bright point sources. In this paper, we present two methods to search for faint neutrino point sources in three years of IceCube data, taken between 2008 and 2011. The first method is an autocorrelation test, applied separately to the northern and southern sky. The second method is a multipole analysis, which expands the measured data in the northern hemisphere into spherical harmonics and uses the resulting expansion coefficients to separate signal from background. With both methods, the results are consistent with the background expectation with a slightly more sparse spatial distribution, corresponding to an underfluctuation. Depending on the assumed number of sources, the resulting upper limit on the flux per source in the northern hemisphere for an E-2 energy spectrum ranges from similar to 1.5. 10(-8) GeV/cm(2) s(-1), in the case of one assumed source, to similar to 4. 10(-10) GeV/cm(2) s(-1), in the case of 3500 assumed sources.
Published: 2015
Full Text: View/download PDF

48. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Author: Cordell, H, Han, Y, Mells, G, Li, Y, Hirschfield, G, Greene, C, Xie, G, Juran, B, Zhu, D, Qian, D, Floyd, J, Morley, K, Prati, D, Lleo, A, Cusi, D, Gershwin, M, Anderson, C, Lazaridis, K, Invernizzi, P, Seldin, M, Sandford, R, Amos, C, Siminovitch, K, Schlicht, E, Lammert, C, Atkinson, E, Chan, L, De Andrade, M, Balschun, T, Mason, A, Myers, R, Zhang, J, Milkiewicz, P, Qu, J, Odin, J, Luketic, V, Bacon, B, Bodenheimer, H, Liakina, V, Vincent, C, Levy, C, Gregersen, P, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Barlassina, C, Battezzati, P, Benedetti, A, Bernuzzi, F, Bianchi, I, Bragazzi, M, Brunetto, M, Bruno, S, Casella, G, Coco, B, Colli, A, Colombo, M, Colombo, S, Cursaro, C, Crocè, L, Crosignani, A, Donato, M, Elia, G, Fabris, L, Ferrari, C, Floreani, A, Foglieni, B, Fontana, R, Galli, A, Lazzari, R, Macaluso, F, Malinverno, F, Marra, F, Marzioni, M, Mattalia, A, Montanari, R, Morini, L, Morisco, F, Mousa Hani, S, Muratori, L, Muratori, P, Niro, G, Palmieri, V, Picciotto, A, Podda, M, Portincasa, P, Ronca, V, Rosina, F, Rossi, S, Sogno, I, Spinzi, G, Spreafico, M, Strazzabosco, M, Tarallo, S, Tarocchi, M, Tiribelli, C, Toniutto, P, Vinci, M, Zuin, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Carbone, M, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Jones, D, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Stephen, D, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali Kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, INVERNIZZI, PIETRO, STRAZZABOSCO, MARIO, CARBONE, MARCO, Kordula, J., Bernuzzi, Francesca Veronica, Cordell, H, Han, Y, Mells, G, Li, Y, Hirschfield, G, Greene, C, Xie, G, Juran, B, Zhu, D, Qian, D, Floyd, J, Morley, K, Prati, D, Lleo, A, Cusi, D, Gershwin, M, Anderson, C, Lazaridis, K, Invernizzi, P, Seldin, M, Sandford, R, Amos, C, Siminovitch, K, Schlicht, E, Lammert, C, Atkinson, E, Chan, L, De Andrade, M, Balschun, T, Mason, A, Myers, R, Zhang, J, Milkiewicz, P, Qu, J, Odin, J, Luketic, V, Bacon, B, Bodenheimer, H, Liakina, V, Vincent, C, Levy, C, Gregersen, P, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Barlassina, C, Battezzati, P, Benedetti, A, Bernuzzi, F, Bianchi, I, Bragazzi, M, Brunetto, M, Bruno, S, Casella, G, Coco, B, Colli, A, Colombo, M, Colombo, S, Cursaro, C, Crocè, L, Crosignani, A, Donato, M, Elia, G, Fabris, L, Ferrari, C, Floreani, A, Foglieni, B, Fontana, R, Galli, A, Lazzari, R, Macaluso, F, Malinverno, F, Marra, F, Marzioni, M, Mattalia, A, Montanari, R, Morini, L, Morisco, F, Mousa Hani, S, Muratori, L, Muratori, P, Niro, G, Palmieri, V, Picciotto, A, Podda, M, Portincasa, P, Ronca, V, Rosina, F, Rossi, S, Sogno, I, Spinzi, G, Spreafico, M, Strazzabosco, M, Tarallo, S, Tarocchi, M, Tiribelli, C, Toniutto, P, Vinci, M, Zuin, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Carbone, M, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Jones, D, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Stephen, D, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali Kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, INVERNIZZI, PIETRO, STRAZZABOSCO, MARIO, CARBONE, MARCO, Kordula, J., and Bernuzzi, Francesca Veronica
Abstract: Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined <5 × 10-8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.
Published: 2015

49. SEARCH FOR PROMPT NEUTRINO EMISSION FROM GAMMA-RAY BURSTS WITH ICECUBE

Author: Aartsen, M. G., primary, Ackermann, M., additional, Adams, J., additional, Aguilar, J. A., additional, Ahlers, M., additional, Ahrens, M., additional, Altmann, D., additional, Anderson, T., additional, Arguelles, C., additional, Arlen, T. C., additional, Auffenberg, J., additional, Bai, X., additional, Barwick, S. W., additional, Baum, V., additional, Bay, R., additional, Beatty, J. J., additional, Tjus, J. Becker, additional, Becker, K.-H., additional, BenZvi, S., additional, Berghaus, P., additional, Berley, D., additional, Bernardini, E., additional, Bernhard, A., additional, Besson, D. Z., additional, Binder, G., additional, Bindig, D., additional, Bissok, M., additional, Blaufuss, E., additional, Blumenthal, J., additional, Boersma, D. J., additional, Bohm, C., additional, Bos, F., additional, Bose, D., additional, Böser, S., additional, Botner, O., additional, Brayeur, L., additional, Bretz, H.-P., additional, Brown, A. M., additional, Buzinsky, N., additional, Casey, J., additional, Casier, M., additional, Cheung, E., additional, Chirkin, D., additional, Christov, A., additional, Christy, B., additional, Clark, K., additional, Classen, L., additional, Clevermann, F., additional, Coenders, S., additional, Cowen, D. F., additional, Silva, A. H. Cruz, additional, Daughhetee, J., additional, Davis, J. C., additional, Day, M., additional, André, J. P. A. M. de, additional, Clercq, C. De, additional, Ridder, S. De, additional, Desiati, P., additional, Vries, K. D. de, additional, With, M. de, additional, DeYoung, T., additional, Vélez, J. C. Díaz-, additional, Dunkman, M., additional, Eagan, R., additional, Eberhardt, B., additional, Ehrhardt, T., additional, Eichmann, B., additional, Eisch, J., additional, Euler, S., additional, Evenson, P. A., additional, Fadiran, O., additional, Fazely, A. R., additional, Fedynitch, A., additional, Feintzeig, J., additional, Felde, J., additional, Filimonov, K., additional, Finley, C., additional, Wasels, T. Fischer-, additional, Flis, S., additional, Frantzen, K., additional, Fuchs, T., additional, Gaisser, T. K., additional, Gaior, R., additional, Gallagher, J., additional, Gerhardt, L., additional, Gier, D., additional, Gladstone, L., additional, Glüsenkamp, T., additional, Goldschmidt, A., additional, Golup, G., additional, Gonzalez, J. G., additional, Goodman, J. A., additional, Góra, D., additional, Grant, D., additional, Gretskov, P., additional, Groh, J. C., additional, Groß, A., additional, Ha, C., additional, Haack, C., additional, Ismail, A. Haj, additional, Hallen, P., additional, Hallgren, A., additional, Halzen, F., additional, Hanson, K., additional, Hebecker, D., additional, Heereman, D., additional, Heinen, D., additional, Helbing, K., additional, Hellauer, R., additional, Hellwig, D., additional, Hickford, S., additional, Hill, G. C., additional, Hoffman, K. D., additional, Hoffmann, R., additional, Homeier, A., additional, Hoshina, K., additional, Huang, F., additional, Huelsnitz, W., additional, Hulth, P. O., additional, Hultqvist, K., additional, Ishihara, A., additional, Jacobi, E., additional, Jacobsen, J., additional, Japaridze, G. S., additional, Jero, K., additional, Jlelati, O., additional, Jurkovic, M., additional, Kaminsky, B., additional, Kappes, A., additional, Karg, T., additional, Karle, A., additional, Kauer, M., additional, Keivani, A., additional, Kelley, J. L., additional, Kheirandish, A., additional, Kiryluk, J., additional, Kläs, J., additional, Klein, S. R., additional, Köhne, J.-H., additional, Kohnen, G., additional, Kolanoski, H., additional, Koob, A., additional, Köpke, L., additional, Kopper, C., additional, Kopper, S., additional, Koskinen, D. J., additional, Kowalski, M., additional, Kriesten, A., additional, Krings, K., additional, Kroll, G., additional, Kroll, M., additional, Kunnen, J., additional, Kurahashi, N., additional, Kuwabara, T., additional, Labare, M., additional, Lanfranchi, J. L., additional, Larsen, D. T., additional, Larson, M. J., additional, Bzdak, M. Lesiak-, additional, Leuermann, M., additional, Lünemann, J., additional, Madsen, J., additional, Maggi, G., additional, Maruyama, R., additional, Mase, K., additional, Matis, H. S., additional, Maunu, R., additional, McNally, F., additional, Meagher, K., additional, Medici, M., additional, Meli, A., additional, Meures, T., additional, Miarecki, S., additional, Middell, E., additional, Middlemas, E., additional, Milke, N., additional, Miller, J., additional, Mohrmann, L., additional, Montaruli, T., additional, Morse, R., additional, Nahnhauer, R., additional, Naumann, U., additional, Niederhausen, H., additional, Nowicki, S. C., additional, Nygren, D. R., additional, Obertacke, A., additional, Odrowski, S., additional, Olivas, A., additional, Omairat, A., additional, O’Murchadha, A., additional, Palczewski, T., additional, Paul, L., additional, Penke, Ö., additional, Pepper, J. A., additional, Heros, C. Pérez de los, additional, Pfendner, C., additional, Pieloth, D., additional, Pinat, E., additional, Posselt, J., additional, Price, P. B., additional, Przybylski, G. T., additional, Pütz, J., additional, Quinnan, M., additional, Rädel, L., additional, Rameez, M., additional, Rawlins, K., additional, Redl, P., additional, Rees, I., additional, Reimann, R., additional, Relich, M., additional, Resconi, E., additional, Rhode, W., additional, Richman, M., additional, Riedel, B., additional, Robertson, S., additional, Rodrigues, J. P., additional, Rongen, M., additional, Rott, C., additional, Ruhe, T., additional, Ruzybayev, B., additional, Ryckbosch, D., additional, Saba, S. M., additional, Sander, H.-G., additional, Sandroos, J., additional, Santander, M., additional, Sarkar, S., additional, Schatto, K., additional, Scheriau, F., additional, Schmidt, T., additional, Schmitz, M., additional, Schoenen, S., additional, Schöneberg, S., additional, Schönwald, A., additional, Schukraft, A., additional, Schulte, L., additional, Schulz, O., additional, Seckel, D., additional, Sestayo, Y., additional, Seunarine, S., additional, Shanidze, R., additional, Smith, M. W. E., additional, Soldin, D., additional, Spiczak, G. M., additional, Spiering, C., additional, Stamatikos, M., additional, Stanev, T., additional, Stanisha, N. A., additional, Stasik, A., additional, Stezelberger, T., additional, Stokstad, R. G., additional, Stößl, A., additional, Strahler, E. A., additional, Ström, R., additional, Strotjohann, N. L., additional, Sullivan, G. W., additional, Taavola, H., additional, Taboada, I., additional, Tamburro, A., additional, Tepe, A., additional, Antonyan, S. Ter-, additional, Terliuk, A., additional, Tešić, G., additional, Tilav, S., additional, Toale, P. A., additional, Tobin, M. N., additional, Tosi, D., additional, Tselengidou, M., additional, Unger, E., additional, Usner, M., additional, Vallecorsa, S., additional, Eijndhoven, N. van, additional, Vandenbroucke, J., additional, Santen, J. van, additional, Vehring, M., additional, Voge, M., additional, Vraeghe, M., additional, Walck, C., additional, Wallraff, M., additional, Weaver, Ch., additional, Wellons, M., additional, Wendt, C., additional, Westerhoff, S., additional, Whelan, B. J., additional, Whitehorn, N., additional, Wichary, C., additional, Wiebe, K., additional, Wiebusch, C. H., additional, Williams, D. R., additional, Wissing, H., additional, Wolf, M., additional, Wood, T. R., additional, Woschnagg, K., additional, Xu, D. L., additional, Xu, X. W., additional, Xu, Y., additional, Yanez, J. P., additional, Yodh, G., additional, Yoshida, S., additional, Zarzhitsky, P., additional, Ziemann, J., additional, and Zoll, M., additional
Published: 2015
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50. SEARCHES FOR EXTENDED AND POINT-LIKE NEUTRINO SOURCES WITH FOUR YEARS OF ICECUBE DATA

Author: Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Macias, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, O., Pepper, J. A., Perez De Los Heros, Carlos, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., Zoll, M., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Beatty, J. J., Tjus, J. Becker, Becker, K. -H, BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, David J., Bohm, C., Bos, F., Bose, D., Boeser, S., Botner, Olga, Brayeur, L., Bretz, H. -P, Brown, A. M., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Christy, B., Clark, K., Classen, L., Clevermann, F., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Danninger, M., Daughhetee, J., Davis, J. C., Day, M., de Andre, J. P. A. M., De Clercq, C., De Ridder, S., Desiati, P., de Vries, K. D., de With, M., DeYoung, T., Diaz-Velez, J. C., Dunkman, M., Eagan, R., Eberhardt, B., Eichmann, B., Eisch, J., Euler, Sebastian, Evenson, P. A., Fadiran, O., Fazely, A. R., Fedynitch, A., Feintzeig, J., Felde, J., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Franckowiak, A., Frantzen, K., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Gier, D., Gladstone, L., Gluesenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Goodman, J. A., Gora, D., Grandmont, D. T., Grant, D., Gretskov, P., Groh, J. C., Gross, A., Ha, C., Haack, C., Ismail, A. Haj, Hallen, P., Hallgren, Allan, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Heinen, D., Helbing, K., Hellauer, R., Hellwig, D., Hickford, S., Hill, G. C., Hoffman, K. D., Hoffmann, R., Homeier, A., Hoshina, K., Huang, F., Huelsnitz, W., Hulth, P. O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobi, E., Jacobsen, J., Jagielski, K., Japaridze, G. S., Jero, K., Jlelati, O., Jurkovic, M., Kaminsky, B., Kappes, A., Karg, T., Karle, A., Kauer, M., Kelley, J. L., Kheirandish, A., Kiryluk, J., Klaes, J., Klein, S. R., Koehne, J. -H, Kohnen, G., Kolanoski, H., Koob, A., Koepke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Kriesten, A., Krings, K., Kroll, G., Kroll, M., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Larsen, D. T., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leute, J., Luenemann, J., Macias, O., Madsen, J., Maggi, G., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Meures, T., Miarecki, S., Middell, E., Middlemas, E., Milke, N., Miller, J., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Odrowski, S., Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Paul, L., Penek, O., Pepper, J. A., Perez De Los Heros, Carlos, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Puetz, J., Quinnan, M., Raedel, L., Rameez, M., Rawlins, K., Redl, P., Rees, I., Reimann, R., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rodrigues, J. P., Rongen, M., Rott, C., Ruhe, T., Ruzybayev, B., Ryckbosch, D., Saba, S. M., Sander, H. -G, Sandroos, J., Santander, M., Sarkar, S., Schatto, K., Scheriau, F., Schmidt, T., Schmitz, M., Schoenen, S., Schoeneberg, S., Schoenwald, A., Schukraft, A., Schulte, L., Schulz, O., Seckel, D., Sestayo, Y., Seunarine, S., Shanidze, R., Sheremata, C., Smith, M. W. E., Soldin, D., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stanisha, N. A., Stasik, A., Stezelberger, T., Stokstad, R. G., Stoessl, A., Strahler, E. A., Ström, Rickard, Strotjohann, N. L., Sullivan, G. W., Taavola, Henric, Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Terliuk, A., Tesic, G., Tilav, S., Toale, P. A., Tobin, M. N., Tosi, D., Tselengidou, M., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., Vandenbroucke, J., van Santen, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallraff, M., Weaver, Ch., Wellons, M., Wendt, C., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wichary, C., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Yanez, J. P., Yodh, G., Yoshida, S., Zarzhitsky, P., Ziemann, J., Zierke, S., and Zoll, M.
Abstract: We present results on searches for point-like sources of neutrinos using four years of IceCube data, including the first year of data from the completed 86 string detector. The total livetime of the combined data set is 1373 days. For an E-2 spectrum, the observed 90% C. L. flux upper limits are similar to 10(-12) TeV-1 cm(-2) s(-1) for energies between 1 TeV and 1 PeV in the northern sky and similar to 10(-11) TeV-1 cm(-2) s(-1) for energies between 100 TeV and 100 PeV in the southern sky. This represents a 40% improvement compared to previous publications, resulting from both the additional year of data and the introduction of improved reconstructions. In addition, we present the first results from an all-sky search for extended sources of neutrinos. We update the results of searches for neutrino emission from stacked catalogs of sources and test five new catalogs; two of Galactic supernova remnants and three of active galactic nuclei. In all cases, the data are compatible with the background-only hypothesis, and upper limits on the flux of muon neutrinos are reported for the sources considered.
Published: 2014
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