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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Authors :
Cordell, H Han, Y Mells, G Li, Y Hirschfield, G Greene, C Xie, G Juran, B Zhu, D Qian, D Floyd, J Morley, K Prati, D Lleo, A Cusi, D Gershwin, M Anderson, C Lazaridis, K Invernizzi, P Seldin, M Sandford, R Amos, C Siminovitch, K Schlicht, E Lammert, C Atkinson, E Chan, L De Andrade, M Balschun, T Mason, A Myers, R Zhang, J Milkiewicz, P Qu, J Odin, J Luketic, V Bacon, B Bodenheimer, H Liakina, V Vincent, C Levy, C Gregersen, P Almasio, P Alvaro, D Andreone, P Andriulli, A Barlassina, C Battezzati, P Benedetti, A Bernuzzi, F Bianchi, I Bragazzi, M Brunetto, M Bruno, S Casella, G Coco, B Colli, A Colombo, M Colombo, S Cursaro, C Crocè, L Crosignani, A Donato, M Elia, G Fabris, L Ferrari, C Floreani, A Foglieni, B Fontana, R Galli, A Lazzari, R Macaluso, F Malinverno, F Marra, F Marzioni, M Mattalia, A Montanari, R Morini, L Morisco, F Mousa Hani, S Muratori, L Muratori, P Niro, G Palmieri, V Picciotto, A Podda, M Portincasa, P Ronca, V Rosina, F Rossi, S Sogno, I Spinzi, G Spreafico, M Strazzabosco, M Tarallo, S Tarocchi, M Tiribelli, C Toniutto, P Vinci, M Zuin, M Ch'Ng, C Rahman, M Yapp, T Sturgess, R Healey, C Czajkowski, M Gunasekera, A Gyawali, P Premchand, P Kapur, K Marley, R Foster, G Watson, A Dias, A Subhani, J Harvey, R Mccorry, R Ramanaden, D Gasem, J Evans, R Mathialahan, T Shorrock, C Lipscomb, G Southern, P Tibble, J Gorard, D Palegwala, A Jones, S Carbone, M Dawwas, M Alexander, G Dolwani, S Prince, M Foxton, M Elphick, D Mitchison, H Gooding, I Karmo, M Saksena, S Mendall, M Patel, M Ede, R Austin, A Sayer, J Hankey, L Hovell, C Fisher, N Carter, M Koss, K Piotrowicz, A Grimley, C Neal, D Lim, G Levi, S Ala, A Broad, A Saeed, A Wood, G Brown, J Wilkinson, M Gordon, H Ramage, J Ridpath, J Ngatchu, T Grover, B Shaukat, S Shidrawi, R Abouda, G Ali, F Rees, I Salam, I Narain, M Brown, A Taylor Robinson, S Williams, S Grellier, L Banim, P Das, D Chilton, A Heneghan, M Curtis, H Gess, M Drake, I Aldersley, M Davies, M Jones, R Mcnair, A Srirajaskanthan, R Pitcher, M Sen, S Bird, G Barnardo, A Kitchen, P Yoong, K Chirag, O Sivaramakrishnan, N Macfaul, G Jones, D Shah, A Evans, C Saha, S Pollock, K Bramley, P Mukhopadhya, A Fraser, A Mills, P Shallcross, C Campbell, S Bathgate, A Shepherd, A Dillon, J Rushbrook, S Przemioslo, R Macdonald, C Metcalf, J Shmueli, U Davis, A Naqvi, A Lee, T Stephen, D Collier, J Klass, H Ninkovic, M Cramp, M Sharer, N Aspinall, R Goggin, P Ghosh, D Douds, A Hoeroldt, B Booth, J Williams, E Hussaini, H Stableforth, W Ayres, R Thorburn, D Marshall, E Burroughs, A Mann, S Lombard, M Richardson, P Patanwala, I Maltby, J Brookes, M Mathew, R Vyas, S Singhal, S Gleeson, D Misra, S Butterworth, J George, K Harding, T Douglass, A Panter, S Shearman, J Bray, G Butcher, G Forton, D Mclindon, J Cowan, M Whatley, G Mandal, A Gupta, H Sanghi, P Jain, S Pereira, S Prasad, G Watts, G Wright, M Neuberger, J Gordon, F Unitt, E Grant, A Delahooke, T Higham, A Brind, A Cox, M Ramakrishnan, S King, A Collins, C Whalley, S Li, A Fraser, J Bell, A Wong, V Singhal, A Gee, I Ang, Y Ransford, R Gotto, J Millson, C Bowles, J Thomas, C Harrison, M Galaska, R Kendall, J Whiteman, J Lawlor, C Gray, C Elliott, K Mulvaney Jones, C Hobson, L Van Duyvenvoorde, G Loftus, A Seward, K Penn, R Maiden, J Damant, R Hails, J Cloudsdale, R Silvestre, V Glenn, S Dungca, E Wheatley, N Doyle, H Kent, M Hamilton, C Braim, D Wooldridge, H Abrahams, R Paton, A Lancaster, N Gibbins, A Hogben, K Desousa, P Muscariu, F Musselwhite, J Mckay, A Tan, L Foale, C Brighton, J Flahive, K Nambela, E Townshend, P Ford, C Holder, S Palmer, C Featherstone, J Nasseri, M Sadeghian, J Williams, B Rolls, S Hynes, A Duggan, C Crossey, M Stansfield, G Macnicol, C Wilkins, J Wilhelmsen, E Raymode, P Lee, H Durant, E Bishop, R Ncube, N Tripoli, S Casey, R Cowley, C Miller, R Houghton, K Ducker, S Wright, F Bird, B Baxter, G Keggans, J Hughes, M Grieve, E Young, K Williams, D Ocker, K Hines, F Martin, K Innes, C Valliani, T Fairlamb, H Thornthwaite, S Eastick, A Tanqueray, E Morrison, J Holbrook, B Browning, J Walker, K Congreave, S Verheyden, J Slininger, S Stafford, L O'Donnell, D Ainsworth, M Lord, S Kent, L March, L Dickson, C Simpson, D Longhurst, B Hayes, M Shpuza, E White, N Besley, S Pearson, S Wright, A Jones, L Gunter, E Dewhurst, H Fouracres, A Farrington, L Graves, L Marriott, S Leoni, M Tyrer, D Dali Kemmery, L Lambourne, V Green, M Sirdefield, D Amor, K Colley, J Shinder, B Jones, J Mills, M Carnahan, M Taylor, N Boulton, K Tregonning, J Brown, C Clifford, G Archer, E Hamilton, M Curtis, J Shewan, T Walsh, S Warner, K Netherton, K Mupudzi, M Gunson, B Gitahi, J Gocher, D Batham, S Pateman, H Desmennu, S Conder, J Clement, D Gallagher, S Orpe, J Chan, P Currie, L O'Donohoe, L Oblak, M Morgan, L Quinn, M Amey, I Baird, Y Cotterill, D Cumlat, L Winter, L Greer, S Spurdle, K Allison, J Dyer, S Sweeting, H Kordula, J INVERNIZZI, PIETRO STRAZZABOSCO, MARIO CARBONE, MARCO Kordula, J. Bernuzzi, Francesca Veronica Cordell, H Han, Y Mells, G Li, Y Hirschfield, G Greene, C Xie, G Juran, B Zhu, D Qian, D Floyd, J Morley, K Prati, D Lleo, A Cusi, D Gershwin, M Anderson, C Lazaridis, K Invernizzi, P Seldin, M Sandford, R Amos, C Siminovitch, K Schlicht, E Lammert, C Atkinson, E Chan, L De Andrade, M Balschun, T Mason, A Myers, R Zhang, J Milkiewicz, P Qu, J Odin, J Luketic, V Bacon, B Bodenheimer, H Liakina, V Vincent, C Levy, C Gregersen, P Almasio, P Alvaro, D Andreone, P Andriulli, A Barlassina, C Battezzati, P Benedetti, A Bernuzzi, F Bianchi, I Bragazzi, M Brunetto, M Bruno, S Casella, G Coco, B Colli, A Colombo, M Colombo, S Cursaro, C Crocè, L Crosignani, A Donato, M Elia, G Fabris, L Ferrari, C Floreani, A Foglieni, B Fontana, R Galli, A Lazzari, R Macaluso, F Malinverno, F Marra, F Marzioni, M Mattalia, A Montanari, R Morini, L Morisco, F Mousa Hani, S Muratori, L Muratori, P Niro, G Palmieri, V Picciotto, A Podda, M Portincasa, P Ronca, V Rosina, F Rossi, S Sogno, I Spinzi, G Spreafico, M Strazzabosco, M Tarallo, S Tarocchi, M Tiribelli, C Toniutto, P Vinci, M Zuin, M Ch'Ng, C Rahman, M Yapp, T Sturgess, R Healey, C Czajkowski, M Gunasekera, A Gyawali, P Premchand, P Kapur, K Marley, R Foster, G Watson, A Dias, A Subhani, J Harvey, R Mccorry, R Ramanaden, D Gasem, J Evans, R Mathialahan, T Shorrock, C Lipscomb, G Southern, P Tibble, J Gorard, D Palegwala, A Jones, S Carbone, M Dawwas, M Alexander, G Dolwani, S Prince, M Foxton, M Elphick, D Mitchison, H Gooding, I Karmo, M Saksena, S Mendall, M Patel, M Ede, R Austin, A Sayer, J Hankey, L Hovell, C Fisher, N Carter, M Koss, K Piotrowicz, A Grimley, C Neal, D Lim, G Levi, S Ala, A Broad, A Saeed, A Wood, G Brown, J Wilkinson, M Gordon, H Ramage, J Ridpath, J Ngatchu, T Grover, B Shaukat, S Shidrawi, R Abouda, G Ali, F Rees, I Salam, I Narain, M Brown, A Taylor Robinson, S Williams, S Grellier, L Banim, P Das, D Chilton, A Heneghan, M Curtis, H Gess, M Drake, I Aldersley, M Davies, M Jones, R Mcnair, A Srirajaskanthan, R Pitcher, M Sen, S Bird, G Barnardo, A Kitchen, P Yoong, K Chirag, O Sivaramakrishnan, N Macfaul, G Jones, D Shah, A Evans, C Saha, S Pollock, K Bramley, P Mukhopadhya, A Fraser, A Mills, P Shallcross, C Campbell, S Bathgate, A Shepherd, A Dillon, J Rushbrook, S Przemioslo, R Macdonald, C Metcalf, J Shmueli, U Davis, A Naqvi, A Lee, T Stephen, D Collier, J Klass, H Ninkovic, M Cramp, M Sharer, N Aspinall, R Goggin, P Ghosh, D Douds, A Hoeroldt, B Booth, J Williams, E Hussaini, H Stableforth, W Ayres, R Thorburn, D Marshall, E Burroughs, A Mann, S Lombard, M Richardson, P Patanwala, I Maltby, J Brookes, M Mathew, R Vyas, S Singhal, S Gleeson, D Misra, S Butterworth, J George, K Harding, T Douglass, A Panter, S Shearman, J Bray, G Butcher, G Forton, D Mclindon, J Cowan, M Whatley, G Mandal, A Gupta, H Sanghi, P Jain, S Pereira, S Prasad, G Watts, G Wright, M Neuberger, J Gordon, F Unitt, E Grant, A Delahooke, T Higham, A Brind, A Cox, M Ramakrishnan, S King, A Collins, C Whalley, S Li, A Fraser, J Bell, A Wong, V Singhal, A Gee, I Ang, Y Ransford, R Gotto, J Millson, C Bowles, J Thomas, C Harrison, M Galaska, R Kendall, J Whiteman, J Lawlor, C Gray, C Elliott, K Mulvaney Jones, C Hobson, L Van Duyvenvoorde, G Loftus, A Seward, K Penn, R Maiden, J Damant, R Hails, J Cloudsdale, R Silvestre, V Glenn, S Dungca, E Wheatley, N Doyle, H Kent, M Hamilton, C Braim, D Wooldridge, H Abrahams, R Paton, A Lancaster, N Gibbins, A Hogben, K Desousa, P Muscariu, F Musselwhite, J Mckay, A Tan, L Foale, C Brighton, J Flahive, K Nambela, E Townshend, P Ford, C Holder, S Palmer, C Featherstone, J Nasseri, M Sadeghian, J Williams, B Rolls, S Hynes, A Duggan, C Crossey, M Stansfield, G Macnicol, C Wilkins, J Wilhelmsen, E Raymode, P Lee, H Durant, E Bishop, R Ncube, N Tripoli, S Casey, R Cowley, C Miller, R Houghton, K Ducker, S Wright, F Bird, B Baxter, G Keggans, J Hughes, M Grieve, E Young, K Williams, D Ocker, K Hines, F Martin, K Innes, C Valliani, T Fairlamb, H Thornthwaite, S Eastick, A Tanqueray, E Morrison, J Holbrook, B Browning, J Walker, K Congreave, S Verheyden, J Slininger, S Stafford, L O'Donnell, D Ainsworth, M Lord, S Kent, L March, L Dickson, C Simpson, D Longhurst, B Hayes, M Shpuza, E White, N Besley, S Pearson, S Wright, A Jones, L Gunter, E Dewhurst, H Fouracres, A Farrington, L Graves, L Marriott, S Leoni, M Tyrer, D Dali Kemmery, L Lambourne, V Green, M Sirdefield, D Amor, K Colley, J Shinder, B Jones, J Mills, M Carnahan, M Taylor, N Boulton, K Tregonning, J Brown, C Clifford, G Archer, E Hamilton, M Curtis, J Shewan, T Walsh, S Warner, K Netherton, K Mupudzi, M Gunson, B Gitahi, J Gocher, D Batham, S Pateman, H Desmennu, S Conder, J Clement, D Gallagher, S Orpe, J Chan, P Currie, L O'Donohoe, L Oblak, M Morgan, L Quinn, M Amey, I Baird, Y Cotterill, D Cumlat, L Winter, L Greer, S Spurdle, K Allison, J Dyer, S Sweeting, H Kordula, J INVERNIZZI, PIETRO STRAZZABOSCO, MARIO CARBONE, MARCO Kordula, J. Bernuzzi, Francesca Veronica
Publication Year :
2015
Abstract
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined <5 × 10-8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1308916005
Document Type :
Electronic Resource