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Your search keyword '"Reddy, D. Shekhar"' showing total 21 results
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21 results on '"Reddy, D. Shekhar"'

1. First neutron diffraction analysis of an O-H...pi hydrogen bond: 2-ethynyladamantan-2-ol

Author

Allen, Frank H., Howard, Judith A.K., Hoy, Vanessa J., Desiraju, Gautam R., Reddy, D. Shekhar, and Wilson, Chick C.

Subjects
Hydrogen bonding -- Research, Crystal optics -- Research, Chemistry
Abstract

The structure of 2-ethynyladamantan-1-ol is analyzed using neutron diffraction techniques to determine the types of hydrogen bonds it contains. Results indicate the presence of an unusual hydrogen bond of the type O-H...pi, aside from the more common O-H...O and C-H...O bonds. The novel bond points to its center, rather than the alkynic carbon atoms, when it is directed towards a -C=C- bond. A very short and straight C-H...0 bond is also shown to be present.

Published
1996

2. Solid state architecture and synthon robustness in some 2,3-dicyano-5,6-dichloro-1,4-dialkoxybenzenes

Author

Reddy, D. Shekhar, Ovchinnikov, Yuri E., Shishkin, Oleg V., Struchkov, Yuri T., and Desiraju, Gautam R.

Subjects
Crystals -- Structure, Solid state chemistry -- Research, Chemistry
Abstract

Intermolecular interactions lead to the formation of structural units called synthons in crystals. It has been hypothesized that a lack of correspondence between molecular and crystal structures resulting from synthon interference could cause problems in the engineering of crystals. To test this hypothesis, the structural chemistry of a series of 1,4-disubstituted 2,3-dicyano-5,6-dichlorobenzenes and related compounds is determined.

Published
1996

3. Structure simplication and synthon interchangeability in some organic diamondoid solids

Author

Reddy, D. Shekhar, Craig, Donald C., and Desiraju, Gautam R.

Subjects
Crystals -- Structure, Organic compounds -- Research, Diamond crystals -- Research, Chemical structure -- Research, Chemistry
Abstract

The crystal structure of organic diamondoid solids is simplified into a network that is dissected into nodes and node connections. The effects of the node connections, or supramolecular synthons, on crystal packing and their interchangeability with molecular synthons show that simplifying the crystal structure can be a useful strategy for crystal structure design, particularly in complex networks.

Published
1996

4. Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Author

Hernandez, Vincent, primary, Crépin, Thibaut, additional, Palencia, Andrés, additional, Cusack, Stephen, additional, Akama, Tsutomu, additional, Baker, Stephen J., additional, Bu, Wei, additional, Feng, Lisa, additional, Freund, Yvonne R., additional, Liu, Liang, additional, Meewan, Maliwan, additional, Mohan, Manisha, additional, Mao, Weimin, additional, Rock, Fernando L., additional, Sexton, Holly, additional, Sheoran, Anita, additional, Zhang, Yanchen, additional, Zhang, Yong-Kang, additional, Zhou, Yasheen, additional, Nieman, James A., additional, Anugula, Mahipal Reddy, additional, Keramane, El Mehdi, additional, Savariraj, Kingsley, additional, Reddy, D. Shekhar, additional, Sharma, Rashmi, additional, Subedi, Rajendra, additional, Singh, Rajeshwar, additional, O'Leary, Ann, additional, Simon, Nerissa L., additional, De Marsh, Peter L., additional, Mushtaq, Shazad, additional, Warner, Marina, additional, Livermore, David M., additional, Alley, M. R. K., additional, and Plattner, Jacob J., additional

Published
2013
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18. Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Author

Hernandez, Vincent, Crépin, Thibaut, Palencia, Andrés, Cusack, Stephen, Akama, Tsutomu, Baker, Stephen J., Bu, Wei, Feng, Lisa, Freund, Yvonne R., Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Mao, Weimin, Rock, Fernando L., Sexton, Holly, Sheoran, Anita, Zhang, Yanchen, Zhang, Yong-Kang, Zhou, Yasheen, Nieman, James A., Anugula, Mahipal Reddy, Keramane, El Mehdi, Savariraj, Kingsley, Reddy, D. Shekhar, Sharma, Rashmi, Subedi, Rajendra, Singh, Rajeshwar, O'Leary, Ann, Simon, Nerissa L., De Marsh, Peter L., Mushtaq, Shazad, Warner, Marina, Livermore, David M., Alley, M. R. K., and Plattner, Jacob J.

Abstract

ABSTRACTGram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which only partially overcome existing resistance mechanisms. Therefore, new classes of Gram-negative antibacterials with truly novel modes of action are needed to circumvent these existing resistance mechanisms. We have previously identified a new a way to inhibit an aminoacyl-tRNA synthetase, leucyl-tRNA synthetase (LeuRS), in fungi via the oxaborole tRNA trapping (OBORT) mechanism. Herein, we show how we have modified the OBORT mechanism using a structure-guided approach to develop a new boron-based antibiotic class, the aminomethylbenzoxaboroles, which inhibit bacterial leucyl-tRNA synthetase and have activity against Gram-negative bacteria by largely evading the main efflux mechanisms in Escherichia coliand Pseudomonas aeruginosa. The lead analogue, AN3365, is active against Gram-negative bacteria, including Enterobacteriaceaebearing NDM-1 and KPC carbapenemases, as well as P. aeruginosa. This novel boron-based antibacterial, AN3365, has good mouse pharmacokinetics and was efficacious against E. coliand P. aeruginosain murine thigh infection models, which suggest that this novel class of antibacterials has the potential to address this unmet medical need.

Published
2012
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