1. Assembly and antifungal effect of a new fluconazole-carrier nanosystem
- Author
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Raphael Fb Ferraresse, Emerson R. Camargo, Bruno Hr de Lima, Taynara Mt de Lima, Juliano Pelim Pessan, Douglas Roberto Monteiro, Laís Salomão Arias, Francisco Nunes de Souza Neto, Letícia F Afanaci, Fabiana Gouveia Straioto, University of Western São Paulo (UNOESTE), Universidade Estadual Paulista (Unesp), Chemi Engenharia de Materiais, and Universidade Federal de São Carlos (UFSCar)
- Subjects
0301 basic medicine ,Microbiology (medical) ,Antifungal Agents ,Drug Compounding ,030106 microbiology ,Candida glabrata ,Microbial Sensitivity Tests ,Microbiology ,Chitosan ,03 medical and health sciences ,chemistry.chemical_compound ,Minimum inhibitory concentration ,fluconazole ,Candida albicans ,medicine ,Fluconazole ,Candida ,Drug Carriers ,biology ,iron oxide nanoparticles ,Biofilm ,biology.organism_classification ,030104 developmental biology ,chemistry ,Biofilms ,Nanoparticles ,biofilms ,chitosan ,Nanocarriers ,Iron oxide nanoparticles ,medicine.drug - Abstract
Made available in DSpace on 2020-12-12T02:02:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01 Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (
- Published
- 2020