Assembly and antifungal effect of a new fluconazole-carrier nanosystem

Authors :: Raphael Fb Ferraresse
Emerson R. Camargo
Bruno Hr de Lima
Taynara Mt de Lima
Juliano Pelim Pessan
Douglas Roberto Monteiro
Laís Salomão Arias
Francisco Nunes de Souza Neto
Letícia F Afanaci
Fabiana Gouveia Straioto
University of Western São Paulo (UNOESTE)
Universidade Estadual Paulista (Unesp)
Chemi Engenharia de Materiais
Universidade Federal de São Carlos (UFSCar)
Source :: Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
Publication Year :: 2020
Publisher :: Future Medicine Ltd, 2020.
Abstract: Made available in DSpace on 2020-12-12T02:02:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01 Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (

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