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Genes linked to brahma (brm), a stimulator of homeotic gene expression in Drosophila, were screened to establish possible regulators of Hox gene expression. brg1, a cloned murine gene, may be a DNA-dependent ATPase or a helicase, because it encodes a member of the DEGH proteins family. Hox gene regulation and other regulatory routes may involve the action of brg1.

The Antennapedia Complex (ANT-C) of Drosophila (D) pseudoobscura was cloned to determine the rigidity of its organization and to provide further understanding of its evolutionary changes. Results revealed that the structural characteristics of ANT-C in D pseudoobscura is highly identical with that found in D melanogaster, except that the psudoobscura ANT-C lacks the z2 gene. In addition, in D pseudoobscura, the Deformed gene's orientation is inverted and has a 5' to 3' transcription direction. These indicate that the ANT-C structure is not rigid and can be altered even during a short period of evolutionary divergence.

Determines the activation of Wnt/beta-catenin pathway in human colon cancers. Effect of beta-catenin antisense oligodeoxynucleotides on the level of axin2 and human naked cuticle (hnkd) mRNA; Expression of axin2 and hnkd in colon cancer cell lines; Correlation of the increased expression of axin2 and hnkd with truncations in polyposis coli.