1. High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia
- Author
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Ivars Tolmanis, Aigars Vanags, Inta Liepniece-Karele, Selga Savcenko, Darhan Samentaev, Ilze Kikuste, Linda Mezmale, Marcis Leja, Tatjana Belihina, Nurbek Igissinov, Ramis Samsutdinov, Altynbek Tazedinov, Maria Blanca Piazuelo, Sergejs Isajevs, and Indra Gulbe
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Biopsy ,Population ,Pilot Projects ,Gastroenterology ,Risk Assessment ,Severity of Illness Index ,Article ,Pathology and Forensic Medicine ,Helicobacter Infections ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,education ,Molecular Biology ,Early Detection of Cancer ,education.field_of_study ,Metaplasia ,High prevalence ,Helicobacter pylori ,business.industry ,Intestinal metaplasia ,Cancer ,Cell Biology ,General Medicine ,Middle Aged ,medicine.disease ,Subtyping ,Healthy Volunteers ,Intestines ,030104 developmental biology ,030220 oncology & carcinogenesis ,Gastritis ,Female ,Cancer development ,medicine.symptom ,business ,Precancerous Conditions - Abstract
The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Healthy adult volunteers aged 40–64 years were invited to undergo upper endoscopy within a regional GISTAR pilot study in Kazakhstan (n = 166). Gastric lesions were staged according to OLGA/OLGIM staging system. High iron diamine–alcian blue (HID-AB) was used for subtyping IM. IM prevalence overall was 45.8%. Incomplete IM was present in 52.6% (type II in 30.3% and type III in 22.3%), whereas complete IM was found in 47.4% individuals. The prevalence of OLGIM I and II stage were 39.8 and 4.8%, respectively, whereas OLGIM III was observed in 1.2%. The prevalence of incomplete IM in patients stratified to OLGIM I was 54.5% (type II in 31.8% and type III in 22.7%). High prevalence of incomplete IM was detected not only in subjects with extensive IM, but in those stratified as at the OLGIM I stage. Without IM subtyping, patients with high risk of gastric cancer development would be missed for surveillance.
- Published
- 2021