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High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia
- Source :
- Virchows Arch
- Publication Year :
- 2021
-
Abstract
- The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Healthy adult volunteers aged 40–64 years were invited to undergo upper endoscopy within a regional GISTAR pilot study in Kazakhstan (n = 166). Gastric lesions were staged according to OLGA/OLGIM staging system. High iron diamine–alcian blue (HID-AB) was used for subtyping IM. IM prevalence overall was 45.8%. Incomplete IM was present in 52.6% (type II in 30.3% and type III in 22.3%), whereas complete IM was found in 47.4% individuals. The prevalence of OLGIM I and II stage were 39.8 and 4.8%, respectively, whereas OLGIM III was observed in 1.2%. The prevalence of incomplete IM in patients stratified to OLGIM I was 54.5% (type II in 31.8% and type III in 22.7%). High prevalence of incomplete IM was detected not only in subjects with extensive IM, but in those stratified as at the OLGIM I stage. Without IM subtyping, patients with high risk of gastric cancer development would be missed for surveillance.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Biopsy
Population
Pilot Projects
Gastroenterology
Risk Assessment
Severity of Illness Index
Article
Pathology and Forensic Medicine
Helicobacter Infections
03 medical and health sciences
0302 clinical medicine
Risk Factors
Stomach Neoplasms
Internal medicine
medicine
Humans
Stage (cooking)
education
Molecular Biology
Early Detection of Cancer
education.field_of_study
Metaplasia
High prevalence
Helicobacter pylori
business.industry
Intestinal metaplasia
Cancer
Cell Biology
General Medicine
Middle Aged
medicine.disease
Subtyping
Healthy Volunteers
Intestines
030104 developmental biology
030220 oncology & carcinogenesis
Gastritis
Female
Cancer development
medicine.symptom
business
Precancerous Conditions
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Virchows Arch
- Accession number :
- edsair.doi.dedup.....798d07fec51de185bf15ce46957bdec5