37 results on '"Raineri, G"'
Search Results
2. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency
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Mascolo, M.C., Cursaro, C., Scuteri, A., Ranieri, J., Monti, M., Bellentani, S., Gasbarrini, A., Pompili, M., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Raimondo, G., Scribano, L., Martines, D., Baroni, G. Svegliati, Faraci, G., Schianchi, S., Fornaciari, G., Fabris, P., Madonia, S., Civitavecchia, G., Pirisi, M., Smirne, C., Borghi, A., Sardini, C., Andreoletti, M., Morisco, F., Caporaso, N., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M.E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Mecenate, F., Pasulo, L., Lucà, M.G., Picardi, A., Vespasiani, U., Grattagliano, I., Palasciano, G., Romagno, D., Crespi, C., Gianstefani, A., Gobbo, G., Monti, V., Giannelli, G., Napoli, N., Nosotti, Raspanti, A., Cuccorese, Colombo, A.E., Floridia, Plattella, M.S., Cassano, P., Gentile, I., Blanc, P.L., Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., De Stefano, G., Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Raineri, G., Massari, M., Grossi, P.A., Caputo, S., Cassola, G., Feasi, M., Foti, G., Kunkar, A., Corti, G., Baragli, F., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Baiguera, C., Puoti, M., Brancaccio, G., Gaeta, G.B., Vento, S., Di Biagio, A., Nicolini, L., Liberti, A., Iannece, M.D., Contini, C., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Messeri, D., Esperti, F.C., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A.L., Lomonaco, L., Calì, A., Mandelli, G., Spinzi, G.C., Framarin, L., Berrutti, M., Boccia, S., Simone, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F.G., Bertin, T., Salvagnini, M., Samori, A., Ferretti, E., Casiraghi, M.A., Marin, R., Ciancio, A., Campo, N., Testa, R., Rocco, A., Federico, A., Loguercio, C., Rizzo, S., Giannini, E.G., Corbo, M., Riegler, G., Esposito, P., Ricci, G.L., Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, and Rizzetto, Mario
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- 2014
- Full Text
- View/download PDF
3. Fungal infections in marrow transplant recipients under antifungal prophylaxis with fluconazole
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Oliveira J.S.R., Kerbauy F.R., Colombo A.L., Bahia D.M.M., Pinheiro G.S., Silva M.R.R., Ribeiro M.S.S., Raineri G., and Kerbauy J.
- Subjects
Bone marrow transplantation ,Fungal infections ,Fluconazole prophylaxis ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Fungal infection is one of the most important causes of morbidity and mortality in bone marrow transplant (BMT) recipients. The growing incidence of these infections is related to several factors including prolonged granulocytopenia, use of broad-spectrum antibiotics, conditioning regimens, and use of immunosuppression to avoid graft-versus-host disease (GvHD). In the present series, we report five cases of invasive mold infections documented among 64 BMT recipients undergoing fluconazole antifungal prophylaxis: 1) A strain of Scedosporium prolificans was isolated from a skin lesion that developed on day +72 after BMT in a chronic myeloid leukemic patient. 2) Invasive pulmonary aspergillosis (Aspergillus fumigatus) was diagnosed on day +29 in a patient with a long period of hospitalization before being transplanted for severe aplastic anemia. 3) A tumoral lung lesion due to Rhizopus arrhizus (zygomycosis) was observed in a transplanted patient who presented severe chronic GvHD. 4) A tumoral lesion due to Aspergillus spp involving the 7th, 8th and 9th right ribs and local soft tissue was diagnosed in a BMT patient on day +110. 5) A patient with a history of Ph1-positive acute lymphocytic leukemia exhibited a cerebral lesion on day +477 after receiving a BMT during an episode of severe chronic GvHD. At that time, blood and spinal fluid cultures yielded Fusarium sp. Opportunistic infections due to fungi other than Candida spp are becoming a major problem among BMT patients receiving systemic antifungal prophylaxis with fluconazole.
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- 2002
4. Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections
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Leone, Sebastiano, Borrè, Silvio, Monforte, Antonella D'arminio, Mordente, Gennaro, Petrosillo, Nicola, Signore, Alberto, Venditti, Mario, Viale, Pierluigi, Nicastri, Emanuele, Lauria, Francesco N, Carosi, Giampiero, Moroni, Mauro, Ippolito, Giuseppe, Azzini Am, Camera M, Carbonara S, Davì A, Foti G, Galati V, Gentile I, Mariano A, Piro S, Quarta M, Raineri G, Riccio G, Rinaldi R, Rosati S, Santopuoli D, Tascini C, Veccia S., Leone, Sebastiano, Borrè, Silvio, Monforte, Antonella D'arminio, Mordente, Gennaro, Petrosillo, Nicola, Signore, Alberto, Venditti, Mario, Viale, Pierluigi, Nicastri, Emanuele, Lauria, Francesco N, Carosi, Giampiero, Moroni, Mauro, Ippolito, Giuseppe, Azzini, Am, Camera, M, Carbonara, S, Davì, A, Foti, G, Galati, V, Gentile, I, Mariano, A, Piro, S, Quarta, M, Raineri, G, Riccio, G, Rinaldi, R, Rosati, S, Santopuoli, D, Tascini, C, Veccia, S., Leone S, Borrè S, Monforte A, Mordente G, Petrosillo N, Signore A, Venditti M, Viale P, Nicastri E, Lauria FN, Carosi G, Moroni M, and Ippolito G
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Microbiology (medical) ,Methicillin-Resistant Staphylococcus aureus ,medicine.medical_specialty ,one-stage approach ,Prosthesis-Related Infections ,methicillin-resistant staphylococci ,Joint replacement ,Prosthetic joint ,medicine.medical_treatment ,Staphylococcus ,prosthetic joint infections ,Prosthesis ,law.invention ,Randomized controlled trial ,Staphylococcu ,Multidisciplinary approach ,law ,medicine ,Humans ,Hip Prosthesi ,prosthetic joint infection ,Prosthesis-Related Infection ,Intensive care medicine ,Randomized Controlled Trials as Topic ,Clinical Trials as Topic ,conservative surgical approach ,Evidence-Based Medicine ,business.industry ,Methicillin-Resistant Staphylococcus aureu ,two-stage approach ,Retrospective cohort study ,Knee Prosthesi ,General Medicine ,Evidence-based medicine ,Staphylococcal Infections ,Surgery ,Hip Prosthesis ,Knee Prosthesis ,Treatment Outcome ,Infectious Diseases ,CONSENSUS ,Medline database ,business ,Human - Abstract
Summary Background Joint replacement surgery has been on the increase in recent decades and prosthesis infection remains the most critical complication. Many aspects of the primary prevention and clinical management of such prosthesis infections still need to be clarified. Controversial issues The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group – a panel of multidisciplinary experts – was to define recommendations for the following controversial issues: (1) Is a conservative surgical approach for the management of prosthetic joint infections effective? (2) Is the one-stage or the two-stage revision for the management of prosthetic joint infections more effective? (3) What is the most effective treatment for the management of prosthetic joint infections due to methicillin-resistant staphylococci? Results are presented and discussed in detail. Methods A systematic literature search using the MEDLINE database for the period 1988 to 2008 of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle–Ottawa Quality Assessment Scale for case–control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence and strength of recommendation was applied.
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- 2010
5. First combined findings of in-situ fossil wood and pollen of Parrotia persica and cf. Eucommia sp. in late Early Pleistocene deposits from the northern Apennine fringe (N Italy)
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PINI R., CASTELLANO L., RAVAZZI C., RAINERI G., BONA F., and SALA B.
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- 2014
6. Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections.Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections
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Sebastiano, Leone, Silvio, Borrè, Antonella d'Arminio Monforte, Gennaro, Mordente, Nicola, Petrosillo, Alberto, Signore, Mario, Venditti, Pierluigi, Viale, Emanuele, Nicastri, Francesco, N Lauria, Giampiero, Carosi, Mauro, Moroni, Giuseppe, Ippolito, GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group on Prosthetic Joint Infections Collaborators, M Azzini, A, Camera, M, Carbonara, S, Davì, A, Foti, G, Galati, V, Gentile, I, Mariano, A, Piro, S, Quarta, M, Raineri, G, Riccio, G, Rinaldi, R, Rosati, S, Santopuoli, D, Tascini, C, and Veccia, S
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therapy ,diagnosis ,prosthetic joint infections - Published
- 2010
7. Alterations of anthropometric and metabolic parameters correlate with early increase in IFN-g and TNF-a production after starting antiretroviral treatment in ART-naive HIV patients
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Biglino, Alberto, Brusa, Mt, Bolla, C, Martini, C, Concialdi, E, Mascolo, M, Raineri, G, and Gobber, M.
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- 2006
8. Tuberculosis in HIV-infected persons in the context of wide availability of highly active antiretroviral therapy
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Girardi, E., Antonucci, G., Vanacore, P., Palmieri, F., Matteelli, A., Iemoli, E., Carradori, S., Salassa, B., Pasticci, M. B., Raviglione, M. C., Ippolito, G., Babudieri, S., Bassetti, M., Rosso, R., Carbonara, S., Celesia, B. M., Chirianni, A., Di Perri, G., Fabietti, P., Gabutti, A., Guadagnino, V., Manfrin, V., Zacchini, F., Burzacchini, F., Giacometti, A., Tassara, A., Traverso, A., Giorni, P., Gobbi, M., Mariani, R., Di Gennaro, G., Panella, L., Losappio, R., Beltrami, C., Costigliola, P., Fasulo, G., Moling, O., Bertelli, D., Tedoldi, S., Potenza, D., Manconi, P. E., Zichichi, S., Nacca, C., Fatuzzo, F., La Rosa, R., Galvagna, S., Grosso, C., Vecchiet, J., Longoni, E., Guaglianone, L., Pan, A., Pellicano, S., Raineri, G., Ferrara, S., Anzalone, E., Gallo, A., Cataldini, S., Dodi, F., Petronio, A., Salone, G., De Luca Andrioli, E. P., De Checchi, G., Villa, M., Pardelli, R., Tardio, A., Urbani, C., Gattuso, G., Matini, L., Casciano, G., Loschiavo, F., Errante, I., Giani, G., Meraviglia, P., Molteni, C., Guaraldi, G., Foresti, S., Abbrescia, N., Izzo, C., Filippini, P., Noce, S., Dalle Nogare, E. R., Farinella, E., Sacchi, P., Scudeller, L., Petrelli, E., Alterio, L., Paolillo, F., Savalli, E., Doria, R., Catalani, M., Brizzi, M., Storaci, N., Natalini Raponi, G. P., Martelli, L. T., Grisetti, S., Lanini, S., and Santopadre, P.
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Male ,Epidemiology ,Antitubercular Agents ,Severity of Illness Index ,Cohort Studies ,Antiretroviral Therapy, Highly Active ,Prospective Studies ,Sida ,biology ,Incidence (epidemiology) ,Incidence ,Antiretroviral therapy ,HIV infection ,Italy ,Multicenter study ,Tuberculosis ,AIDS-Related Opportunistic Infections ,Adult ,Age Distribution ,Chi-Square Distribution ,Female ,Follow-Up Studies ,Humans ,Logistic Models ,Middle Aged ,Sex Distribution ,Statistics, Nonparametric ,Survival Rate ,Treatment Outcome ,Tuberculosis, Pulmonary ,Statistics ,virus diseases ,Pulmonary ,Cohort study ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Antiretroviral Therapy ,Context (language use) ,Acquired immunodeficiency syndrome (AIDS) ,Tuberculosis diagnosis ,Internal medicine ,medicine ,Highly Active ,Nonparametric ,business.industry ,medicine.disease ,biology.organism_classification ,Immunology ,business - Abstract
Highly active antiretroviral therapy (HAART) greatly reduces the risk of developing tuberculosis for HIV-infected persons. Nonetheless, HIV-associated tuberculosis continues to occur in countries where HAART is widely used. To identify the characteristics of HIV-infected persons who develop tuberculosis in the context of the availability of HAART, the current authors analysed data taken from 271 patients diagnosed, in Italy, during 1999-2000. These patients represent 0.7% of the 40,413 HIV-infected patients cared for in the clinical units participating in this current study. From the data it was observed that 20 patients (7.4%) had a previous episode of tuberculosis whose treatment was not completed. Eighty-one patients (29.9%) were diagnosed with HIV at tuberculosis diagnosis, 108 (39.8%) were aware of their HIV status but were not on antiretroviral treatment and 82 (30.3%) were on antiretroviral treatment. Patients on antiretroviral treatment were significantly less immunosuppressed than patients with HIV diagnosed concurrently with tuberculosis, or other patients not on antiretrovirals (median CD4 lymphocytes count: 220 cells x mm(-3) versus 100 cells x mm(-3), and 109 cells x mm(-3), respectively). No significant differences in clinical presentation of tuberculosis according to antiretroviral therapy status were recorded. Failure of tuberculosis control interventions (e.g. noncompletion of treatment) and of HIV care (delayed diagnosis of HIV infection and suboptimal uptake of therapy) may contribute to continuing occurrence of HIV-associated tuberculosis in a country where highly active antiretroviral therapy is largely available. However, a significant proportion of cases occur in patients who are on antiretroviral treatment.
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- 2004
9. DGI-006 Analysis of Savings If the Treatment of Community-Acquired Pneumonia (CAP) is Switched
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Dogliani, E, primary, Perrino, F, additional, De Rosa, FG, additional, Cattel, F, additional, Raineri, G, additional, Abrate, M, additional, and Paire, M, additional
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- 2013
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10. Short-term adverse effects from and discontiuation of antiretroviral post-exposure prophylaxis
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Fantoni, Massimo, Del Borgo, Cosmo, Puro, V, De Carli, G, Orchi, N, Palvarini, L, Chiodera, A, Iemoli, E, Niero, F, Monti, M, Micheloini, G, Caggese, L, Lodesani, C, Raineri, G, Massari, M, Drenaggi, D, Ippolito, G., Fantoni, Massimo (ORCID:0000-0001-6913-8460), Fantoni, Massimo, Del Borgo, Cosmo, Puro, V, De Carli, G, Orchi, N, Palvarini, L, Chiodera, A, Iemoli, E, Niero, F, Monti, M, Micheloini, G, Caggese, L, Lodesani, C, Raineri, G, Massari, M, Drenaggi, D, Ippolito, G., and Fantoni, Massimo (ORCID:0000-0001-6913-8460)
- Abstract
OBJECTIVE: To evaluate short-term toxicity from and discontinuation of antiretroviral combination prophylaxis in HIV-exposed individuals in Italy. DESIGN: Longitudinal, open study conducted by prospective collection of data in the National Registry of PEP. SETTING: All the Italian centres dedicated to HIV related care and licensed by the Ministry of Health to dispense antiretroviral drugs. STUDY POPULATION: Health care workers and other persons consenting to be treated with post exposure prophylaxis (PEP) after exposures to HIV. RESULTS: Until October, 2000, 207 individuals receiving two nucleoside reverse transcriptase inhibitors (NRTIs), and 354 receiving two NRTIs plus a protease inhibitor (PI) were enrolled. More individuals experienced side-effects in the 3-drug group (53% and 62%, respectively; OR 0.68, (95% CI 0.48-0.98), p < 0.03). However, the proportion of individuals discontinuing prophylaxis because of side-effects did not differ significantly between the 2 groups (21% and 25% respectively; OR 0.82 (95% CI 0.53-1.26); p=0.4). The 43 individuals in the 2 NRTI group discontinued PEP after a mean of 10.4 days of treatment (median 8, range 1-27), similarly to the 88 discontinuations observed in the 3-drug group (mean duration 10.5 days, median 7.5, range 1-26). Type and incidence of specific adverse effects were similar to those reported in the literature. CONCLUSION: Our study indicates that the difference in the proportion of individuals developing side effects and discontinuing PEP is not significant. The rate of discontinuation because of protease inhibitor side-effects does not justify per se the initial use of a less potent PEP regimen. We suggest initiating PEP with a three-drug regimen and discontinuing the protease inhibitor in the case of adverse effects
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- 2001
11. Epidemic Kaposi’s sarcoma in Italy, a country with intravenous drug users as the main group affected by HIV infection
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Tirelli, U., primary, Vaccher, E., additional, Lazzarin, A., additional, Errante, D., additional, Alessi, E., additional, Crosato, I., additional, Spina, M., additional, Zaccarelli, M., additional, Aiuti, F., additional, Moroni, M., additional, Monfardini, S., additional, Greco, D., additional, Ancarani, F., additional, Angarano, G., additional, Baroni, C., additional, Borri, A., additional, Barelli, A., additional, Cagnoni, G., additional, Cajozzo, A., additional, Carbone, A., additional, Cargnel, A., additional, Confalonieri, F., additional, Costigliola, P., additional, Crocchiolo, P., additional, De Agostini, A., additional, Santa, M. Della, additional, Fasan, M., additional, Figoli, F., additional, Fiore, G.P., additional, Garavelli, P.L., additional, Giannelli, F., additional, Galâ, S., additional, Giudici, M.G., additional, Gritti, F.M., additional, Luzi, G., additional, Luzzati, R., additional, Magnani, G., additional, M., Malena, additional, Malfitano, A., additional, Mazzotta, F., additional, Meraviglia, P., additional, Milazzo, F., additional, Milo, D., additional, Ortona, L., additional, Paladini, A., additional, Piersantelli, N., additional, Pristerà, R., additional, Raineri, G., additional, Raise, E., additional, Repetto, L., additional, Rezza, G., additional, Rinaldi, E., additional, Ricchi, E., additional, Riccio, G., additional, Rizzardini, G., additional, Rizzi, M., additional, Rizzo, F., additional, Rosso, R., additional, Salassa, B., additional, Saliva, G., additional, Savalli, E., additional, Scalise, G., additional, Scasso, A., additional, Sinicco, A., additional, Soranzo, M.L., additional, Stellini, R., additional, Sueri, L., additional, Sulis, E., additional, Suter, F., additional, Terragna, A., additional, Troiano, T., additional, Vaglia, A., additional, Visco, G., additional, Foà, R., additional, and Gavosto, F., additional
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- 1991
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12. Risks faced by laboratory workers in the AIDS era
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Petrosillo, N., vincenzo puro, Carli, G., Ippolito, G., Finzi, G., Gherardi, L., Cugini, P., Ferraresi, I., Zenoni, S., Sileo, C., Iuliucci, R., Andreoletti, G., Pischedda, L., Lodi, A., Nurra, G., Rosati, A., Daglio, M., Vlacos, D., Lanave, M., Carzedda, R., Amoddeo, C., Cocco, M. R., Rosi, D., Pitzalis, G., Di Bernardo, L., Bombonato, M., Testini, B., Turrolla, D., Egger, I., Bertucci, R., Fazio, M., Zangrando, D., Berchialla, I., Maccarrone, S., Paradiso, C., Agosta, T., Raineri, G., Pelissero, Vivalda, A., Desperati, M., Bergaglia, M., Contegiacomo, P., Aspiro, E., Burrai, B., Penna, C., Fulgheri, M., Nelli, M., Rebora, M., Garra, L., Fasulo, G., Pirazzini, M. C., Tangenti, M., Libralato, C., Govoni, C., Bonfiglioli, B., Macchioni, A., Gualandi, G., Bonaventura, M. E., Di Nardo, V., Segata, A., Raponi, G., Boscolo, A. R., Tonelli, C., Marchegiano, P., Tovoli, D., Bonini, R., Mercurio, V., Soscia, F., and Martiniello, R.
13. Risk of exposure to bloodborne infection for Italian healthcare workers, by job category and work area
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Puro, V., Gabriella De Carli, Petrosillo, N., Ippolito, G., Finzi, G., Gherardi, L., Cugini, P., Ferraresi, I., Zenoni, S., Sileo, C., Iuliucci, R., Andreoletti, G., Pischedda, L., Lodi, A., Nurra, G., Rosati, A., Daglio, M., Vlacos, D., Lanave, M., Carzedda, R., Amoddeo, C., Cocco, M. R., Rosi, D., Pitzalis, G., Di Bernardo, L., Bombonato, M., Testini, B., Turrolla, D., Egger, I., Bertucci, R., Fazio, M., Zangrando, D., Berchialla, I., Maccarrone, S., Paradiso, C., Agosta, T., Raineri, G., Pelissero, S., Vivalda, A., Desperati, M., Bergaglia, M., Contegiacomo, P., Aspiro, E., Burrai, B., Penna, C., Fulgheri, M., Nelli, M., Rebora, M., Garra, L., Fasulo, G., Pirazzini, M. C., Tangenti, M., Libralato, C., Govoni, C., Bonfiglioli, B., Macchioni, A., Gualandi, G., Bonaventura, M. E., Di Nardo, V., Segata, A., Raponi, G., Boscolo, A. R., Tonelli, C., Marchegiano, P., Tovoli, D., Bonini, R., Mercurio, V., Soscia, F., and Martiniello, R.
14. 'Side' effects of HAART: Decreasing and changing occupational exposure to HIV-infected patients
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Carli, G., Puro, V., nicola petrosillo, Finzi, G., Ferraresi, I., Daglio, M., Amoddeo, C., Bombonato, M., Bertucci, R., Maccarrone, S., Raineri, G., Desperati, M., Contegiacomo, P., Penna, C., Fulgheri, M., Nelli, M., Rebora, M., Fasulo, G., Bonaventura, M. E., Segata, A., Marchegiano, P., Mercurio, V., Ippolito, G., Gherardi, L., Cugini, P., Zenoni, S., Sileo, C., Iuliucci, R., Andreoletti, G., Pischedda, L., Lodi, A., Nurra, G., Rosati, A., Vlacos, D., Lanave, M., Carzedda, R., Cocco, M. R., Rosi, D., Pitzalis, G., Di Bernardo, L., Testini, B., Turrolla, D., Egger, I., Fazio, M., Zangrando, D., Berchialla, I., Paradiso, C., Agosta, T., Pellissero, S., Vivalda, A., Bergaglia, M., Arrigo, C., Aspiro, E., Burrai, B., Garra, L., Pirazzini, M. C., Tangenti, M., Libralato, C., Govoni, C., Bonfiglioli, B., Macchioni, A., Gualandi, G., Di Nardo, V., Raponi, G., Boscolo, A. R., Tonelli, C., Tovoli, D., Bonini, R., Soscia, F., and Martiniello, R.
15. Occupational HIV infection in obstetrics-gynecology: Risk of exposure and post-exposure management,Infezione professionale da HIV in ginecologia: Stima del rischio, gestione post-esposizione e profilassi farmacologica
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Puro, V., D Ubaldo, C., Carli, G., Petrosillo, N., Ippolito, G., Aspiro, E., Battistella, L., Bignamini, M., Bombonato, M., Bonaventura, M. E., Bonini, R., Bottura, P., Burrai, B., Chiodera, A., Chiriacò, P., Cocco, M. R., Contegiacomo, P., Daglio, M., D Anna, C., Desperati, M., Di Bernardo, L., Di Nardo, V., Evaristi, C., Fasulo, G., Ferrario, R., Ferraresi, I., Fichera, M. A., Finzi, G., Francesconi, M., Garra, L., Gherardi, L., Govoni, C., Greco, G., Gulandi, G., Ianeselli, F., Iuliucci, R., Lanave, M., Libralato, C., Lorenzani, M., Maccarrone, S., Marchegiano, P., Masala, P., Marco Massari, Menichetti, F., Mercurio, V., Micheloni, G., Migliorino, G., Milini, P., Nelli, M., Nurra, G., Paradiso, C., Perosino, M., Piccini, G., Pietrobon, F., Pirrazzini, M. C., Poli, C., Polidori, M., Raineri, G., Rebora, M., Regele, M., Rosati, A., Scappini, P., Segata, A., Sileo, C., Simonini, G., Soscia, F., Tangenti, M., Testini, B., Vaira, L. M., and Vlacos, D.
16. Occupational HIV infection in obstetrics-gynecology: Risk of exposure and post-exposure management | Infezione professionale da HIV in ginecologia: Stima del rischio, gestione post-esposizione e profilassi farmacologica
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Puro, V., D Ubaldo, C., Carli, G., nicola petrosillo, Ippolito, G., Aspiro, E., Battistella, L., Bignamini, M., Bombonato, M., Bonaventura, M. E., Bonini, R., Bottura, P., Burrai, B., Chiodera, A., Chiriacò, P., Cocco, M. R., Contegiacomo, P., Daglio, M., D Anna, C., Desperati, M., Di Bernardo, L., Di Nardo, V., Evaristi, C., Fasulo, G., Ferrario, R., Ferraresi, I., Fichera, M. A., Finzi, G., Francesconi, M., Garra, L., Gherardi, L., Govoni, C., Greco, G., Gulandi, G., Ianeselli, F., Iuliucci, R., Lanave, M., Libralato, C., Lorenzani, M., Maccarrone, S., Marchegiano, P., Masala, P., Massari, M., Menichetti, F., Mercurio, V., Micheloni, G., Migliorino, G., Milini, P., Nelli, M., Nurra, G., Paradiso, C., Perosino, M., Piccini, G., Pietrobon, F., Pirrazzini, M. C., Poli, C., Polidori, M., Raineri, G., Rebora, M., Regele, M., Rosati, A., Scappini, P., Segata, A., Sileo, C., Simonini, G., Soscia, F., Tangenti, M., Testini, B., Vaira, L. M., and Vlacos, D.
17. Palaeoclimatic and palaeoenvironmental evolution of the Lower Pleistocene Arda River succession
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Fabrizio Felletti, Daniele Scarponi, Gianluca Raineri, Gaia Crippa, Emma Taddei Ruggiero, Carlo Francou, Mattia Marini, Crippa G., Felletti F., Francou C., Marini M., Raineri G., Ruggiero E.T., and Scarponi D.
- Subjects
Brachiopod ,Paleontology ,Pleistocene ,Climate change ,Calabrian ,Facies analysi ,Mollusc ,Ecological succession ,Geology ,Palaeo-Adriatic - Abstract
The Arda River marine succession, cropping out in western Emilia (northern Italy) represents an excellent site to study past ecosystems dynamics in the frame of Early Pleistocene climate change and tectonic activity. This one-day excursion leads the participants to discover the palaeoclimatic and palaeoenvironmental evolution of the Lower Pleistocene Arda River marine section, unraveled through an integrated use of sedimentological, palaeoecological (molluscs and trace fossils) and geochemical tools. Upsection, the succession was deposited in progressively shallower water and colder climate during phases of advance of fan deltas affected by hyperpycnal flows. It culminates at the top with clast supported alluvial conglomerates and freshwater/terrestrial biota indicating a sea level drop and the establishment of a continental environment. It is very rich in fossils: in the marine part molluscs, brachiopods, corals and echinoderms, besides well preserved trace fossils, are abundant; whereas in the continental part a mammal fauna and freshwater/terrestrial molluscs are occasionally found. Sclerochemical analyses undertaken on bivalve shells indicate that seawater temperature seasonality was the main variable of climate change within the study area during the Early Pleistocene. In particular, strong seasonality and low winter palaeotemperatures were assumed to be the main drivers for the widespread establishment of Arctica islandica populations in the palaeo-Adriatic Sea around 1.80 Ma. During the excursion not only fossils are shown, but also interesting biocalcarenitic bodies with a complex geometry cropping out in the town of Castell’Arquato. The excursion is complemented by the visit to the Giuseppe Cortesi geological and palaeontological museum, housing vertebrate and invertebrate fossil collections.
- Published
- 2020
18. Bio- and lithostratigraphy of lower Pleistocene marine successions in western Emilia (Italy) and their implications for the first occurrence of Arctica islandica in the Mediterranean Sea
- Author
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Gaia Crippa, Stefania Crespi, Maria Rose Petrizzo, Cinzia Bottini, Michele Azzarone, Fabrizio Felletti, Daniele Scarponi, Sergio Raffi, Mattia Marini, Gianluca Raineri, Crippa G., Azzarone M., Bottini C., Crespi S., Felletti F., Marini M., Petrizzo M.R., Scarponi D., Raffi S., and Raineri G.
- Subjects
Mediterranean climate ,Northern guests ,Early Pleistocene ,biology ,Pleistocene ,Biozone ,Foraminifera ,Biostratigraphy ,Calcareous nannofossil ,biology.organism_classification ,Paleontology ,Mediterranean sea ,Arts and Humanities (miscellaneous) ,General Earth and Planetary Sciences ,Facies analysi ,early Pleistocene ,Arctica islandica ,Geology ,Earth-Surface Processes - Abstract
The Arda and Stirone marine successions (Italy) represent key sections for the early Pleistocene; they were deposited continuously within a frame of climate change, recording the Calabrian cooling as testified by the occurrence of the “northern guests,” such as the bivalve Arctica islandica. In addition, although the first occurrence of A. islandica in the Mediterranean Sea was used as the main criterion to mark the former Pliocene-Pleistocene boundary, the age of this bioevent was never well constrained. Here, we describe the Stirone depositional environment and constrain for the first time the section age using calcareous nannofossil and foraminifera biostratigraphy. We also correlate the Arda and Stirone sections using complementary biostratigraphic and magnetostratigraphic data. Our results indicate that A. islandica first occurred in both the successions slightly below the top of the CNPL7 biozone (dated at 1.71 Ma). Comparisons with other lower Pleistocene Mediterranean marine successions indicate that the stratigraphically lowest level where A. islandica first occurred in the Mediterranean Sea is in the Arda and Stirone sections; these environments satisfied the ecological requirements for the establishment and the proliferation of the species, which only subsequently (late Calabrian) has been retrieved in southern Italy and other areas of the Mediterranean Sea.
- Published
- 2019
19. The complex interplay between vitamin D deficiency and diabetes
- Author
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Tomasello, Giovanni, Sinagra, Emanuele, Raimondo, Dario, Cappello, Francesco, Damiano, Giuseppe, Vincenzo Davide Palumbo, Camma, Calogero, Macaluso, Fabio Salvatore, Genco, Chiara, Ciofalo, Marco, Raineri, Anna, Incandela, Maria, Cosentino, Loretta, Raineri, Giovanni, Damiani, Francesco, Abruzzo, Alida, Lo Monte, Attilio Ignazio, Tomasello, G, Sinagra, E, Raimondo, D, Cappello, F, Damiano, G, Palumbo, VD, Cammà, C, Macaluso, FS, Genco, C, Ciofalo, M, Raineri, A, Incandela, M, Cosentino, L, Raineri, G, Damiani, F, Abruzzo, A, and Lo Monte, AI
- Subjects
Settore MED/12 - Gastroenterologia ,TYPE 1 DIABETES, TYPE 2 DIABETES, VITAMIN D - Abstract
It has been recently highlighted the link between vitamin D and metabolic and immunological pro- cesses, which established its role as an essential component of human health preservation. Vitamin D has been defined as natural immune modulators, and through the activation of its receptors (VDRs), it regulates calcium metabolism, cellular growth, proliferation and apoptosis, and other immunological functions. In this setting, vita- min D has also been reported to influence glucose regulation via effects on insulin secretion and action. Vitamin D deficiency is strongly associated with obesity mostly due to the storage of vitamin D in adipose tissue because of its lipophilic properties. The decrease in vitamin D levels may occur through several mechanisms such as a decrease in the calcium concentration, an increase in PTH, or a direct effect of vitamin D on worsening insulin resistance and secretion, augmenting the risk of developing type 2 diabetes. On the other hand, retrospective analysis and observational studies demonstrated high prevalence of vitamin D deficiency in patients with type 1 diabetes and suggested a contributory role in the pathogenesis of type 1 diabetes, specially with certain allelic variations of the VDR. Vitamin D supplementation during pregnancy and early childhood decreased the risk of autoimmune dia- betes and perhaps, even after the onset of diabetes, it may improve glycemic control. In addition, in subjects that are affected by a high risk of developing diabetes (impaired fasting glucose and/or glucose tolerance, possibly without obesity) vitamin D supplementation could be helpful on the prevention of type 2 diabetes
20. Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis.
- Author
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Tonelli R, Smit MR, Castaniere I, Casa GD, Andrisani D, Gozzi F, Bruzzi G, Cerri S, Samarelli AV, Raineri G, Spagnolo P, Rizzoni R, Ball L, Paulus F, Bos LDJ, Clini E, and Marchioni A
- Subjects
- Humans, Male, Female, Aged, Middle Aged, Retrospective Studies, Idiopathic Pulmonary Fibrosis diagnostic imaging, Idiopathic Pulmonary Fibrosis physiopathology, Idiopathic Pulmonary Fibrosis pathology, Tomography, X-Ray Computed methods, Lung diagnostic imaging, Lung physiopathology, Lung pathology
- Abstract
Introduction: The usual interstitial pneumonia (UIP) pattern, hallmark of idiopathic pulmonary fibrosis (IPF), may induce harmful local overdistension during mechanical ventilation given the juxtaposition of different tissue elasticities. Mechanotransduction, linking mechanical stress and strain to molecular pro-fibrotic pathways, likely contributes to fibrosis progression. Understanding the mechanical forces and aeration patterns in the lungs of IPF patients is crucial for unraveling potential mechanisms of disease progression. Quantitative lung computed tomography (CT) can accurately assess the air content of lung regions, thus informing on zonal distension. This study aims to investigate radiological evidence of lung over aeration in spontaneously breathing UIP patients compared to healthy controls during maximal inspiration., Methods: Patients with IPF diagnosis referred to the Center for Rare Lung Diseases of the University Hospital of Modena (Italy) in the period 2020-2023 who underwent High Resolution Computed Tomography (HRCT) scans at residual volume (RV) and total lung capacity (TLC) using standardized protocols were retrospectively considered eligible. Patients with no signs of lung disease at HRCT performed with the same image acquisition protocol nor at pulmonary function test (PFTs) served as controls. Lung segmentation and quantitative analysis were performed using 3D Slicer software. Lung volumes were measured, and specific density thresholds defined over aerated and fibrotic regions. Comparison between over aerated lung at RV and TLC in the two groups and according to lung lobes was sought. Further, the correlation between aerated lung and the extent of fibrosis was assessed and compared at RV and TLC., Results: IPF patients (N = 20) exhibited higher over aerated lung proportions than controls (N = 15) both at RV and TLC (4.5% vs. 0.7%, p < 0.0001 and 13.8% vs. 7%, p < 0.0001 respectively). Over aeration increased significantly from RV to TLC in both groups, with no intergroup difference (p = 0.67). Sensitivity analysis revealed significant variations in over aerated lung areas among lobes when passing from RV to TLC with no difference within lobes (p = 0.28). Correlation between over aeration and fibrosis extent was moderate at RV (r = 0.62, p < 0.0001) and weak at TLC (r = 0.27, p = 0.01), being the two significantly different at interpolation analysis (p < 0.0001)., Conclusions: This study provides the first evidence of radiological signs of lung over aeration in patients with UIP-pattern patients when passing from RV to TLC. These findings offer new insights into the complex interplay between mechanical forces, lung structure, and fibrosis and warrant larger and longitudinal investigations., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
21. Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study.
- Author
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Samarelli AV, Tonelli R, Raineri G, Mastrolia I, Costantini M, Fabbiani L, Catani V, Petrachi T, Bruzzi G, Andrisani D, Gozzi F, Marchioni A, Masciale V, Aramini B, Ruggieri V, Grisendi G, Dominici M, Cerri S, and Clini E
- Abstract
Background: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development. HOXB7, a member of the homeobox ( Hox ) gene family, has been found involved in various cancers., Methods: Immunohistochemical (IHC) analysis was run on lung tissue samples from surgical lung biopsy (SLB) of 19 patients with IPF, retrospectively selected from the IPF database of the University Hospital of Modena. HOXB7 expression was analyzed and compared with that of five patients with no evidence of pulmonary fibrosis as controls., Results: The semi-quantitative analysis of IHC showed that HOXB7 protein expression was higher in IPF patients compared to controls (difference between means = 6.2 ± 2.37, p = 0.0157). Further, HOXB7 expression was higher in IPF patients with a higher extent of fibrosis (50-75%)-measured with high-resolution computer tomography-compared to those with a lower extent (0-25%) (difference between means = 25.74 ± 6.72, p = 0.004)., Conclusions: The expression of HOXB7 is higher in the lung of IPF patients compared to controls, and was represented in different cellular compartments within the lung niche. Further investigations are needed to clarify its role in the pathogenesis and progression of IPF.
- Published
- 2024
- Full Text
- View/download PDF
22. How the Effect of Virtual Reality on Cognitive Functioning Is Modulated by Gender Differences.
- Author
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Righi S, Gavazzi G, Benedetti V, Raineri G, and Viggiano MP
- Abstract
Virtual reality (VR) can be a promising tool to simulate reality in various settings but the real impact of this technology on the human mental system is still unclear as to how VR might (if at all) interfere with cognitive functioning. Using a computer, we can concentrate, enter a state of flow, and still maintain control over our surrounding world. Differently, VR is a very immersive experience which could be a challenge for our ability to allocate divided attention to the environment to perform executive functioning tasks. This may also have a different impact on women and men since gender differences in both executive functioning and the immersivity experience have been referred to by the literature. The present study aims to investigate cognitive multitasking performance as a function of (1) virtual reality and computer administration and (2) gender differences. To explore this issue, subjects were asked to perform simultaneous tasks (span forward and backward, logical-arithmetic reasoning, and visuospatial reasoning) in virtual reality via a head-mounted display system (HDMS) and on a personal computer (PC). Our results showed in virtual reality an overall impairment of executive functioning but a better performance of women, compared to men, in visuospatial reasoning. These findings are consistent with previous studies showing a detrimental effect of virtual reality on cognitive functioning.
- Published
- 2024
- Full Text
- View/download PDF
23. Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis.
- Author
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Samarelli AV, Tonelli R, Raineri G, Bruzzi G, Andrisani D, Gozzi F, Marchioni A, Costantini M, Fabbiani L, Genovese F, Pinetti D, Manicardi L, Castaniere I, Masciale V, Aramini B, Tabbì L, Rizzato S, Bettelli S, Manfredini S, Dominici M, Clini E, and Cerri S
- Abstract
Introduction: Idiopathic pulmonary fibrosis (IPF) severely affects the lung leading to aberrant deposition of extracellular matrix and parenchymal stiffness with progressive functional derangement. The limited availability of fresh tissues represents one of the major limitations to study the molecular profiling of IPF lung tissue. The primary aim of this study was to explore the proteomic profiling yield of archived formalin-fixed paraffin-embedded (FFPE) specimens of IPF lung tissues., Methods: We further determined the protein expression according to respiratory functional decline at the time of biopsy. The total proteins isolated from 11 FFPE samples of IPF patients compared to 3 FFPE samples from a non-fibrotic lung defined as controls, were subjected to label-free quantitative proteomic analysis by liquid chromatography-mass spectrometry (LC-MS/MS) and resulted in the detection of about 400 proteins., Results: After the pairwise comparison between controls and IPF, functional enrichment analysis identified differentially expressed proteins that were involved in extracellular matrix signaling pathways, focal adhesion and transforming growth factor β (TGF-β) signaling pathways strongly associated with IPF onset and progression. Five proteins were significantly over- expressed in the lung of IPF patients with either advanced disease stage (Stage II) or impaired pulmonary function (FVC<75, DLCO<55) compared to controls; these were lymphocyte cytosolic protein 1 (LCP1), peroxiredoxin-2 (PRDX2), transgelin 2 (TAGLN2), lumican (LUM) and mimecan (OGN) that might play a key role in the fibrogenic processes., Discussion: Our work showed that the analysis of FFPE samples was able to identify key proteins that might be crucial for the IPF pathogenesis. These proteins are correlated with lung carcinogenesis or involved in the immune landscape of lung cancer, thus making possible common mechanisms between lung carcinogenesis and fibrosis progression, two pathological conditions at risk for each other in the real life., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Samarelli, Tonelli, Raineri, Bruzzi, Andrisani, Gozzi, Marchioni, Costantini, Fabbiani, Genovese, Pinetti, Manicardi, Castaniere, Masciale, Aramini, Tabbì, Rizzato, Bettelli, Manfredini, Dominici, Clini and Cerri.)
- Published
- 2024
- Full Text
- View/download PDF
24. Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study.
- Author
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Tonelli R, Grasso S, Cortegiani A, Ball L, Castaniere I, Tabbì L, Fantini R, Andrisani D, Gozzi F, Moretti A, Bruzzi G, Manicardi L, Cerri S, Samarelli AV, Raineri G, Murgolo F, Carzoli A, Di Mussi R, Busani S, Rizzoni R, Grasselli G, Clini E, and Marchioni A
- Subjects
- Humans, Respiration, Artificial, Respiratory Mechanics physiology, Lung, Respiratory Distress Syndrome therapy, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial therapy
- Abstract
Background: Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on lung mechanics during MV are lacking. We aimed at describing the physiological effect of lung-protective ventilation in patients with AE-ILD-UIP compared with primary ARDS., Methods: Partitioned lung and chest wall mechanics were assessed in a series of AE-ILD-UIP patients matched 1:1 with primary ARDS as controls (based on BMI and PaO
2 /FiO2 ratio). Three PEEP levels (zero = ZEEP, 4-8 cmH2 O = PEEPLOW , and titrated to achieve positive end-expiratory transpulmonary pressure PL,EE = PEEPTITRATED ) were used for measurements., Results: Ten AE-ILD-UIP patients and 10 matched ARDS were included. In AE-ILD-UIP median PL,EE at ZEEP was - 4.3 [- 7.6- - 2.3] cmH2 O and lung elastance (EL ) 44 [40-51] cmH2 O/L. At PEEPLOW , PL,EE remained negative and EL did not change (p = 0.995) versus ZEEP. At PEEPTITRATED , PL,EE increased to 0.8 [0.3-1.5] cmH2 O and EL to 49 [43-59] (p = 0.004 and p < 0.001 compared to ZEEP and PEEPLOW , respectively). ΔPL decreased at PEEPLOW (p = 0.018) and increased at PEEPTITRATED (p = 0.003). In matched ARDS control PEEP titration to obtain a positive PL,EE did not result in significant changes in EL and ΔPL ., Conclusions: In mechanically ventilated AE-ILD-UIP patients, differently than in patients with primary ARDS, PEEP titrated to obtain a positive PL,EE significantly worsened lung mechanics., (© 2023. BioMed Central Ltd., part of Springer Nature.)- Published
- 2023
- Full Text
- View/download PDF
25. [Enterobiasis in pediatric subjects in north-western Italy: a study of home remedies].
- Author
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Dutto M, Montù D, and Raineri G
- Subjects
- Animals, Child, Child, Preschool, Culture, Enterobius drug effects, Female, Humans, Italy, Male, Mebendazole therapeutic use, Retrospective Studies, Surveys and Questionnaires, Antinematodal Agents therapeutic use, Artemisia absinthium, Enterobiasis drug therapy, Garlic, Medicine, Traditional methods, Phytotherapy methods, Santonin therapeutic use
- Abstract
The present study examines the most common home remedies in the Piedmont region of northwest Italy currently used in the treatment of pediatric enterobiasis, commonly known as pinworm infection. The remedies in question, typically based on popular beliefs and as such are nearly useless, were noted through interviews with subjects who had come to the local Hygiene and Public Health Services offices for information about pinworm prevention and treatment. Analysis of replies by the subjects clearly indicates that local families are ill-prepared to recognize the symptoms this parasitic infection; often it is confused with pediatric ketosis, therefore leading to inappropriate treatment which at times may be potentially harmful to the patient.
- Published
- 2012
26. "Side" effects of HAART: decreasing and changing occupational exposure to HIV-infected patients.
- Author
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De Carli G, Puro V, Petrosillo N, Finzi G, Ferraresi I, Daglio M, Amoddeo C, Bombonato M, Bertucci R, Maccarrone S, Raineri G, Desperati M, Contegiacomo P, Penna C, Fulgheri M, Nelli M, Rebora M, Fasulo G, Bonaventura ME, Segata A, Marchegiano P, Mercurio V, and Ippolito G
- Subjects
- HIV Infections transmission, Humans, Antiretroviral Therapy, Highly Active, HIV Infections prevention & control, Health Personnel, Occupational Exposure
- Abstract
To investigate percutaneous exposures to HIV in the highly active antiretroviral therapy (HAART) era, we performed an analysis of all percutaneous exposures reported from January 1994 to December 1998 in 18 Italian acute-care hospitals. Frequency and rate per 100 prevalent AIDS cases of HIV exposures decreased by 40% (from 4.3% to 2.6%, and from 1.0% to 0.6%, respectively; p<0.001), which were mainly those related to the insertion/manipulation of peripheral vascular access devices (from 7.2% to 4.8%; p=0.05). We conclude that the benefits of HAART have changed the complexity of care required and therefore, the number and type of procedures performed on HIV patients that place the HCW at risk of injury.
- Published
- 2001
27. Short-term adverse effects from and discontinuation of antiretroviral post-exposure prophylaxis.
- Author
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Puro V, De Carli G, Orchi N, Palvarini L, Chiodera A, Fantoni M, Del Borgo C, Iemoli E, Niero F, Monti M, Micheloni G, Caggese L, Lodesani C, Raineri G, Massari M, Drenaggi D, and Ippolito G
- Subjects
- Humans, Anti-HIV Agents adverse effects, HIV Infections prevention & control, Health Personnel, Occupational Exposure
- Abstract
Objective: To evaluate short-term toxicity from and discontinuation of antiretroviral combination prophylaxis in HIV-exposed individuals in Italy., Design: Longitudinal, open study conducted by prospective collection of data in the National Registry of PEP., Setting: All the Italian centres dedicated to HIV related care and licensed by the Ministry of Health to dispense antiretroviral drugs., Study Population: Health care workers and other persons consenting to be treated with post exposure prophylaxis (PEP) after exposures to HIV., Results: Until October, 2000, 207 individuals receiving two nucleoside reverse transcriptase inhibitors (NRTIs), and 354 receiving two NRTIs plus a protease inhibitor (PI) were enrolled. More individuals experienced side-effects in the 3-drug group (53% and 62%, respectively; OR 0.68, (95% CI 0.48-0.98), p < 0.03). However, the proportion of individuals discontinuing prophylaxis because of side-effects did not differ significantly between the 2 groups (21% and 25% respectively; OR 0.82 (95% CI 0.53-1.26); p=0.4). The 43 individuals in the 2 NRTI group discontinued PEP after a mean of 10.4 days of treatment (median 8, range 1-27), similarly to the 88 discontinuations observed in the 3-drug group (mean duration 10.5 days, median 7.5, range 1-26). Type and incidence of specific adverse effects were similar to those reported in the literature., Conclusion: Our study indicates that the difference in the proportion of individuals developing side effects and discontinuing PEP is not significant. The rate of discontinuation because of protease inhibitor side-effects does not justify per se the initial use of a less potent PEP regimen. We suggest initiating PEP with a three-drug regimen and discontinuing the protease inhibitor in the case of adverse effects.
- Published
- 2001
28. Return of motion after simultaneous repair of displaced bucket-handle meniscal tears and anterior cruciate ligament reconstruction.
- Author
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Costouros JG, Raineri GR, and Cannon WD
- Subjects
- Adolescent, Adult, Anterior Cruciate Ligament surgery, Female, Humans, Knee Injuries surgery, Male, Middle Aged, Postoperative Period, Retrospective Studies, Rupture, Treatment Outcome, Anterior Cruciate Ligament Injuries, Knee Injuries physiopathology, Knee Joint physiopathology, Menisci, Tibial surgery, Range of Motion, Articular
- Abstract
Patients with displaced bucket-handle (DBH) meniscal tears in anterior cruciate ligament (ACL)-deficient knees are prone to flexion contracture following meniscal repair and simultaneous ACL reconstruction. It has been suggested that ACL reconstruction be delayed until full range of motion has returned after the meniscal repair. A retrospective analysis was performed comparing the return of extension in patients undergoing simultaneous ACL reconstruction and repair of DBH tears (group A) versus a control group of patients with non-DBH tears (group B). Age, sex, body mass index, duration of time from injury to surgery, and preoperative extension were also compared between groups and evaluated for their significance as risk factors. Patients in group A achieved recovery to -5 degrees and 0 degrees of extension 22% and 35% more slowly, respectively, when compared with group B. These differences were not statistically significant. Female patients tended to heal more rapidly in both groups. We conclude that a one-stage procedure is sufficient in allowing patients with DBH tears in ACL-deficient knees to regain a functional knee to within 5 degrees of full extension.
- Published
- 1999
- Full Text
- View/download PDF
29. [Our experience with a combination of rifampicin and minocycline in the therapy of brucellosis].
- Author
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Grasso E, Mondino P, Spirolazzi MP, Dalmasso G, Raineri G, and Vitiello C
- Subjects
- Adolescent, Adult, Aged, Child, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Time Factors, Brucellosis drug therapy, Minocycline administration & dosage, Rifampin administration & dosage, Tetracyclines administration & dosage
- Abstract
After a brief review of the literature on the treatment of brucellosis the results obtained with a new protocol (Rifampicin + Minocycline for 20 days) are reported. The combination was well-tolerated and undeniably effective producing a 94% cure rate.
- Published
- 1988
30. [295 cases of brucellosis treated with minocycline].
- Author
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Grasso E, Conversa P, Mondino P, Spirolazzi MP, Dalmasso G, and Raineri G
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Doxycycline therapeutic use, Female, Humans, Infant, Male, Middle Aged, Minocycline adverse effects, Recurrence, Brucellosis drug therapy, Minocycline therapeutic use, Tetracyclines therapeutic use
- Abstract
295 cases of acute and subacute cases of brucellosis were treated with minocycline. It is concluded that because of its in vitro activity, its penetrability in macrophages and granulomas and its tolerance, minocycline is the antibiotic of choice for brucellosis.
- Published
- 1987
31. [Biophysics of enzymes and viruses].
- Author
-
RAINERI G
- Subjects
- Biophysics, Enzymes, Viruses
- Published
- 1956
32. [Clinical aspects of aluminum therapy].
- Author
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PAOLINI A and RAINERI G
- Subjects
- Humans, Aluminum therapeutic use, Skin injuries, Skin Diseases, Soft Tissue Injuries
- Published
- 1952
33. [Heavy metals and enzymes].
- Author
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RAINERI G
- Subjects
- Humans, Enzymes pharmacology, Hematopoietic System drug effects, Metals pharmacology, Metals, Heavy
- Published
- 1955
34. [Cells, radiations and tumors].
- Author
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RAINERI G
- Subjects
- Humans, Cell Nucleus, Diploidy, Neoplasms pathology, Radiation
- Published
- 1953
35. [Study on the etiology of cancer].
- Author
-
RAINERI G
- Subjects
- Humans, Carcinogens, Neoplasms
- Published
- 1951
36. [Photosynthesis and molecular resonance].
- Author
-
RAINERI G
- Subjects
- Photosynthesis, Radiation Effects, Vibration
- Published
- 1956
37. [Aluminum therapy].
- Author
-
RAINERI G
- Subjects
- Humans, Aluminum therapeutic use
- Published
- 1952
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