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Copyright of Gaceta Médica de Caracas is the property of Academia Nacional de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Gaceta Médica de Caracas is the property of Academia Nacional de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In recent decades, there has been an increase in the use of composite graft in the closure of the tympanic membrane perforation. The aim of this research is to know the change of tympanogram and audiogram presentation after tympanomastoidectomy surgery using musculus temporalis fascia profunda graft and composite graft. Experimental research was being conducted on 22 Otitis Media Suppurative Chronic patients without cholesteatoma such as 14 patients using musculus temporalis fascia profunda graft and 8 patients using composite graft. The Audiometric tests were being administered twice, before and after tympanomastoidectomy surgery, in other hand tympanometry test was being performed after surgery. Data analysis using independent-t test, paire-t test, and chi square test. The research has shown that the Pure Tone Audiometry post-surgeries were being found higher on composite graft (68,4) in comparison with musculus temporalis fascia profunda graft (55,1), but statistically non-significant (p>0,05). On the contrary, on fascia graft group was being found significantly higher 1,47 than amplitudo composite graft (0,87), statistically significant (p<0,001). Clinical meaning of using musculus temporalis fascia profunda graft is better than composite graft in terms of hearing and tympanic membrane elasticity. [ABSTRACT FROM AUTHOR]

Background: Chronic tonsillitis is chronic inflammation of the palatine tonsils which can be caused by the presence of free radicals that stimulate the formation of pro-inflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) and interleukin-6 (Il-6). Astaxanthin as an antioxidant and anti-inflammatory is thought to reduce levels of proinflammatory cytokines. Aim: To determine plasma levels of TNF-α and palatine tonsill smears in patients with chronic tonsillitis before and after administration of astaxanthin. Method: Research with clinical trial design. Thirty-one subjects who met the inclusion and exclusion criteria in the Ear, Nose, Throat, Head and Neck Surgery clinic in Wahidin Sudirohusodo Hospital and Network Hospital were given astaxanthin 4 mg/day for 14 days. Plasma TNF-α levels and palatine tonsile smears were examined before and after administration of astaxanthin. Data were analyzed using SPSS 25th version. The statistical tests used Paired-t test and Independent-t test. Results: Thirty-one subjects can be followed until the end of the study. Astaxanthin 4 mg per day for 14 days can reduce plasma TNF-α levels and palatine tonsil swab of patients with chronic tonsillitis (p <0.05), and there is no significant difference in TNF-α levels between plasma and palatine tonsil swab both before and after administration astaxanthin (p> 0.05). Conclusion: Astaxanthin can reduce plasma TNF-α levels and palatine tonsil swab in chronic tonsillitis patients. [ABSTRACT FROM AUTHOR]