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8. Characteristics of pleural effusion due to amyloidosis

Author

Pou, Cristina, Ferreiro, Lucía, Suárez-Antelo, Juan, Golpe, Antonio, Álvarez-Dobaño, José M., Toubes, María Elena, Lama, Adriana, Rodríguez-Núñez, Nuria, Ricoy, Jorge, Rábade, Carlos, Lourido, Tamara, and Valdés, Luis

Subjects
Microsoft Corp., Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Chemotherapy -- Health aspects, Cancer -- Chemotherapy, Amyloidosis -- Health aspects, Pleural effusions -- Health aspects, Health
Abstract

The characteristics of patients with pleural amyloidosis (PA) are poorly known. A systematic review was performed of studies reporting clinical findings, pleural fluid (PF) characteristics, and the most effective treatment of PA. Case descriptions and retrospective studies were included. The review included 95 studies with a total sample of 196 patients. The mean age was 63 years, male/female ratio was 1.6:1, and 91.9 of patients were >50 years. The most common symptom was dyspnea (88 patients). PF was generally serious (63), predominantly lymphocytic, and with the biochemical characteristics of transudates (43.4) or exudates (42.6). Pleural effusion was generally bilateral (55) and Keywords: Amyloidosis, pleural effusion, pleural fluid, Author(s): Cristina Pou [1]; Lucía Ferreiro (corresponding author) [2,3]; Juan Suárez-Antelo [2]; Antonio Golpe [2,3]; José M. Álvarez-Dobaño [2,3]; María Elena Toubes [2]; Adriana Lama [2]; Nuria Rodríguez-Núñez [2]; Jorge [...]

Published
2023
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9. Sarcoidosis. Disease progression based on radiological and functional course: Predictive factors

Author

Casal, Ana, Suárez-Antelo, Juan, Soto-Feijóo, Roi, Ferreiro, Lucía, Rodríguez-Núñez, Nuria, Lama, Adriana, Riveiro, Vanessa, Toubes, Mª Elena, Lourido, Tamara, Ricoy, Jorge, Rábade, Carlos, Zamarrón, Carlos, Rodríguez, Carlota, Abelleira, Romina, Álvarez-Dobaño, José Manuel, Golpe, Antonio, de Alegría, Anxo Martínez, Antúnez, José Ramón, Gude, Francisco, and Valdés, Luis

Published
2022
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12. Diabetes and obstructive sleep apnoea: A case-control study

Author

Abelleira, Romina, primary, Zamarrón, Carlos, additional, Riveiro, Vanessa, additional, Casal, Ana, additional, Toubes, María E., additional, Rábade, Carlos, additional, Ricoy, Jorge, additional, Lama, Adriana, additional, Rodríguez-Núñez, Nuria, additional, Ferreiro, Lucía, additional, and Valdés, Luis, additional

Published
2023
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14. Diabetes y apnea obstructiva del sueño. Un estudio de casos y controles

Author

Abelleira, Romina, primary, Zamarrón, Carlos, additional, Riveiro, Vanessa, additional, Casal, Ana, additional, Toubes, María E., additional, Rábade, Carlos, additional, Ricoy, Jorge, additional, Lama, Adriana, additional, Rodríguez-Núñez, Nuria, additional, Ferreiro, Lucía, additional, and Valdés, Luis, additional

Published
2023
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15. Development and validation of a clinical score to estimate progression to severe or critical state in COVID-19 pneumonia hospitalized patients

Author

Gude, Francisco, Riveiro, Vanessa, Rodríguez-Núñez, Nuria, Ricoy, Jorge, Lado-Baleato, Óscar, Lourido, Tamara, Rábade, Carlos, Lama, Adriana, Casal, Ana, Abelleira-París, Romina, Ferreiro, Lucía, Suárez-Antelo, Juan, Toubes, María E., Pou, Cristina, Taboada-Muñiz, Manuel, Calle-Velles, Felipe, Mayán-Conesa, Plácido, del Molino, María L. Pérez, Galbán-Rodríguez, Cristóbal, Álvarez-Escudero, Julián, Beceiro-Abad, Carmen, Molinos-Castro, Sonia, Agra-Vázquez, Néstor, Pazo-Núñez, María, Páez-Guillán, Emilio, Varela-García, Pablo, Martínez-Rey, Carmen, Pernas-Pardavila, Hadrián, Domínguez-Santalla, María J., Vidal-Vázquez, Martín, Marques-Afonso, Ana T., González-Quintela, Arturo, González-Juanatey, José R., Pose, Antonio, and Valdés, Luis

Published
2020
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16. Characteristics of pleural effusion due to amyloidosis

Author

Ferreiro, Lucía, primary, Pou, Cristina, additional, Suárez-Antelo, Juan, additional, Golpe, Antonio, additional, Álvarez-Dobaño, JoséM, additional, Toubes, MaríaElena, additional, Lama, Adriana, additional, Rodríguez-Núñez, Nuria, additional, Ricoy, Jorge, additional, Rábade, Carlos, additional, Lourido, Tamara, additional, and Valdés, Luis, additional

Published
2023
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20. Cost-Effectiveness of a New Outpatient Pulmonology Care Model Based on Physician-to-Physician Electronic Consultation

Author

Álvarez-Dobaño, José Manuel, primary, Toubes, Malena, additional, Novo-Platas, José Ángel, additional, Reyes-Santías, Francisco, additional, Atienza, Gerardo, additional, Portela, Manuel, additional, Rábade, Carlos, additional, Lourido, Tamara, additional, Casal, Ana, additional, Rodríguez-García, Carlota, additional, Riveiro, Vanessa, additional, Abelleira, Romina, additional, Ricoy, Jorge, additional, Rodríguez-Núñez, Nuria, additional, Zamarrón, Carlos, additional, Calle, Felipe, additional, Gude, Francisco, additional, and Valdés, Luis, additional

Published
2022
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21. Risk Factors of Mortality in Hospitalized Patients With COVID-19 Applying a Machine Learning Algorithm

Author

Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular, Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Nieto Codesido, Irene, Diego, Carmen, Hammouri, Z., Ginzo Villamayor, María José, Salgado, Francisco Javier, Martín Carreira, José, Rábade, Carlos, Barbeito, Gema, González Perez, Miguel Ángel, Gonzalez-Barcala, Francisco-Javier, Calvo Álvarez, Uxío, Mallah, Narmeen, Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular, Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Nieto Codesido, Irene, Diego, Carmen, Hammouri, Z., Ginzo Villamayor, María José, Salgado, Francisco Javier, Martín Carreira, José, Rábade, Carlos, Barbeito, Gema, González Perez, Miguel Ángel, Gonzalez-Barcala, Francisco-Javier, Calvo Álvarez, Uxío, and Mallah, Narmeen

Abstract

Introduction Risk stratification of patients with COVID-19 can be fundamental to support clinical decision-making and optimize resources. The objective of our study is to identify among the routinely tested clinical and analytical parameters those that would allow us to determine patients with the highest risk of dying from COVID-19. Material and methods We carried out a retrospective cohort multicentric study by consecutively, including hospitalized patients with COVID-19 admitted in any of the 11 hospitals in the healthcare network of HM Hospitals-Spain. We collected the clinical, demographic, analytical, and radiological data from the patient's medical records. To assess each of the biomarkers’ predictive impact and measure the statistical significance of the variables involved in the analysis, we applied a random forest with a permutation method. We used the similarity measure induced by a previously classification model and adjusted the k-groups clustering algorithm based on the energy distance to stratify patients into a high and low-risk group. Finally, we adjusted two optimal classification trees to have a schematic representation of the cut-off points. Results We included 1246 patients (average age of 65.36 years, 62% males). During the study one hundred sixty-eight patients (13%) died. High values of age, D-Dimer, White Blood Cell, Na, CRP, and creatinine represent the factors that identify high-risk patients who would die. Conclusions Age seems to be the primary predictor of mortality in patients with SARS-CoV-2 infection, while the impact of acute phase reactants and blood cellularity is also highly relevant.

Published
2022

22. Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 pneumonia: an open-label, randomised clinical trial

Author

Taboada, Manuel, primary, Rodríguez, Nuria, additional, Varela, Pablo Manuel, additional, Rodríguez, María Teresa, additional, Abelleira, Romina, additional, González, Amara, additional, Casal, Ana, additional, Díaz Peromingo, José Antonio, additional, Lama, Adriana, additional, Domínguez, María Jesús, additional, Rábade, Carlos, additional, Páez, Emilio Manuel, additional, Riveiro, Vanessa, additional, Pernas, Hadrián, additional, Beceiro, María del Carmen, additional, Caruezo, Valentín, additional, Naveira, Alberto, additional, Cariñena, Agustín, additional, Cabaleiro, Teresa, additional, Estany-Gestal, Ana, additional, Zarra, Irene, additional, Pose, Antonio, additional, Valdés, Luis, additional, and Álvarez-Escudero, Julián, additional

Published
2021
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27. Evaluation of the impact of an integrated care pathway for pulmonary embolism: a quasi-experimental pre-post study

Author

Rodríguez-Núñez, Nuria, primary, Ruano-Raviña, Alberto, additional, Lama, Adriana, additional, Ferreiro, Lucía, additional, Ricoy, Jorge, additional, Álvarez-Dobaño, José M., additional, Suárez-Antelo, Juan, additional, Toubes, M. Elena, additional, Rábade, Carlos, additional, Golpe, Antonio, additional, Riveiro, Vanessa, additional, Casal, Ana, additional, Abelleira, Romina, additional, González-Barcala, Francisco Javier, additional, González-Juanatey, José R., additional, and Valdés, Luis, additional

Published
2021
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30. Impact of cardiovascular risk factors on the clinical presentation and survival of pulmonary embolism without identifiable risk factor

Author

Rodríguez-Núñez, Nuria, primary, Ruano-Raviña, Alberto, additional, Lama, Adriana, additional, Ferreiro, Lucía, additional, Ricoy, Jorge, additional, Álvarez-Dobaño, José M., additional, Suárez-Antelo, Juan, additional, Toubes, M. Elena, additional, Rábade, Carlos, additional, Golpe, Antonio, additional, Lourido, Tamara, additional, González-Barcala, Francisco Javier, additional, and Valdés, Luis, additional

Published
2020
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33. Discordance of physician clinical judgment vs. pneumonia severity index (PSI) score to admit patients with low risk community-acquired pneumonia: a prospective multicenter study

Author

Marcos, Pedro J., primary, Restrepo, Marcos I., additional, González-Barcala, Francisco J., additional, Soni, Nilam J., additional, Vidal, Iria, additional, Sanjuàn, Pilar, additional, Llinares, Diego, additional, Ferreira-Gonzalez, Lucía, additional, Rábade, Carlos, additional, Otero-González, Isabel, additional, Marcos, Pedro, additional, and Verea-Hernando, Héctor, additional

Published
2017
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35. Urinothorax: a systematic review

Author

Toubes, María E., primary, Lama, Adriana, additional, Ferreiro, Lucía, additional, Golpe, Antonio, additional, Álvarez-Dobaño, José M., additional, González-Barcala, Francisco J., additional, San José, Esther, additional, Rodríguez-Núñez, Nuria, additional, Rábade, Carlos, additional, Lourido, Tamara, additional, and Valdés, Luis, additional

Published
2017
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37. Predictive models of malignant transudative pleural effusions

Author

Ferreiro, Lucía, primary, Gude, Francisco, additional, Toubes, María E., additional, Lama, Adriana, additional, Suárez-Antelo, Juan, additional, San-José, Esther, additional, González-Barcala, Francisco Javier, additional, Golpe, Antonio, additional, Álvarez-Dobaño, José M., additional, Rábade, Carlos, additional, Rodríguez-Núñez, Nuria, additional, Díaz-Louzao, Carla, additional, and Valdés, Luis, additional

Published
2017
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38. Characteristics of patients with pseudochylothorax—a systematic review

Author

Lama, Adriana, primary, Ferreiro, Lucía, additional, Toubes, María E., additional, Golpe, Antonio, additional, Gude, Francisco, additional, Álvarez-Dobaño, José M., additional, González-Barcala, Francisco J., additional, José, Esther San, additional, Rodríguez-Núñez, Nuria, additional, Rábade, Carlos, additional, Rodríguez-García, Carlota, additional, and Valdés, Luis, additional

Published
2016
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39. Predicting malignant and tuberculous pleural effusions through demographics and pleural fluid analysis of patients

Author

Valdés, Luis, primary, San-José, Esther, additional, Ferreiro, Lucía, additional, Golpe, Antonio, additional, González-Barcala, Francisco-Javier, additional, Toubes, María E., additional, Rodríguez-Álvarez, María X., additional, Álvarez-Dobaño, José M., additional, Rodríguez-Núñez, Nuria, additional, Rábade, Carlos, additional, and Gude, Francisco, additional

Published
2014
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40. Evolución de la prevalencia de consumo de tabaco en España y sus 17 Comunidades Autónomas (1987-2020)

Author

Brandariz, Julia Rey, Ravina, Alberto Ruano, Santiago-Pérez, María Isolina, Lema, Leonor Varela, Tort, Carla Guerra, Montes, Agustín, Piñeiro, María, Rábade, Carlos, and Ríos, Mónica Pérez

Abstract

Antecedentes y objetivos: La monitorización continua de la prevalencia de consumo de tabaco es fundamental para conocer la evolución de la epidemia tabáquica en una población. El objetivo de este estudio fue analizar la evolución de la prevalencia de fumadores en España y sus 17 Comunidades Autónomas (CCAA) en población ≥15 años durante el periodo 1987-2020.

Published
2023
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41. Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 pneumonia: an open-label, randomised clinical trial.

Author

Taboada M, Rodríguez N, Varela PM, Rodríguez MT, Abelleira R, González A, Casal A, Díaz Peromingo JA, Lama A, Domínguez MJ, Rábade C, Páez EM, Riveiro V, Pernas H, Beceiro MDC, Caruezo V, Naveira A, Cariñena A, Cabaleiro T, Estany-Gestal A, Zarra I, Pose A, Valdés L, and Álvarez-Escudero J

Subjects
Aged, Dexamethasone, Female, Humans, Male, Middle Aged, Oxygen, SARS-CoV-2, Treatment Outcome, COVID-19 Drug Treatment
Abstract

Background: Low-dose dexamethasone demonstrated clinical improvement in patients with coronavirus disease 2019 (COVID-19) needing oxygen therapy; however, evidence on the efficacy of high-dose dexamethasone is limited., Methods: We performed a randomised, open-label, controlled trial involving hospitalised patients with confirmed COVID-19 pneumonia needing oxygen therapy. Patients were randomly assigned in a 1:1 ratio to receive low-dose dexamethasone (6 mg once daily for 10 days) or high-dose dexamethasone (20 mg once daily for 5 days, followed by 10 mg once daily for an additional 5 days). The primary outcome was clinical worsening within 11 days since randomisation. Secondary outcomes included 28-day mortality, time to recovery and clinical status at day 5, 11, 14 and 28 on an ordinal scale ranging from 1 (discharged) to 7 (death)., Results: A total of 200 patients (mean±sd age 64±14 years; 62% male) were enrolled. 32 (31.4%) out of 102 patients enrolled in the low-dose group and 16 (16.3%) out of 98 in the high-dose group showed clinical worsening within 11 days since randomisation (rate ratio 0.427, 95% CI 0.216-0.842; p=0.014). The 28-day mortality was 5.9% in the low-dose group and 6.1% in the high-dose group (p=0.844). There was no significant difference in time to recovery, and in the seven-point ordinal scale at days 5, 11, 14 and 28., Conclusions: Among hospitalised COVID-19 patients needing oxygen therapy, high dose of dexamethasone reduced clinical worsening within 11 days after randomisation, compared with low dose., Competing Interests: Conflict of interest: The authors declare the absence of conflict of interests., (Copyright ©The authors 2022.)

Published
2022
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