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The present study was aimed at contributing to the understanding of the role of pre-service special education teachers' attachment styles and empathy dimensions in sentiments, attitudes, and concerns towards disability. Participants were 536 pre-service special education teachers (78.4% females and 21.6% males), Results of the path analysis showed that some empathy dimensions (fantasy and personal distress) played a mediating role in the association between preoccupied and fearful attachment styles and teachers' sentiments and concerns towards disability. Moreover, a direct positive association was reported from preoccupied attachment style to sentiments and concerns towards disability, from fantasy and personal distress (both dimensions of empathy) to sentiments towards disability, from personal distress to concerns towards disability, and from empathic concerns to attitudes towards disability, whereas negative relationships were found from perspective-taking to concerns and sentiments towards disability, as well as from empathic concern to sentiments towards disability.

The purpose of this study was to investigate the mediating role of problem-solving coping strategies in the relationship between thinking styles (legislative, executive, and judicial) and teachers' attitudes towards distance education (difficulties related to distance education and efficacy in distance education). The study sample consisted of 556 special education teachers, 122 males (21.9%) and 434 females (78.1%), with an average age of 37.90 years (SD = 7.12). The results confirmed the role of problem-solving coping as a mediator for legislative thinking style on difficulties related to distance education. Furthermore, the findings indicated a positive relationship between judicial style and efficacy in distance education. The results of this study highlight the importance of developing specific special education teacher trainings to promote positive attitudes towards distance education.

The coronavirus disease (COVID-19) pandemic has brought the One Health concept to the forefront of global health. From an infectious disease standpoint, the focus of One Health is often on [...]

The article analyzes market failures that affected the voluntary carbon market (VCM) and its policy implications. Topics discussed include role of the VCM in mitigating climate change, carbon offsets, evolution and structure of the VCM, regulations related with the VCM, command and control regulations, gatekeeper liability and regulatory licenses, and the importance of transparency and strengthening of reputational sanctions for inaccurate certifications.

Background: Leiomyosarcoma (LMS) originating from the adrenal gland is exceedingly rare, constituting a minute fraction of soft tissue sarcomas. Due to its rarity, with less than 50 documented cases in English medical literature, the diagnosis and management of adrenal LMS remain challenging. The aim of this study was to perform a review of the literature, in order to evaluate the prognosis of these rare cancers and report our specific case. Methods: A systematic review of the literature was conducted using PubMed, Web of Science, Google Scholar, and Scopus databases, up to December 2020. The search utilized MeSH terms such as "Adrenal Gland Neoplasms," "Leiomyosarcoma," "Adrenalectomy," and "Smooth Muscle Tumor." The inclusion criteria focused on studies reporting patients with a histopathological diagnosis of adrenal leiomyosarcoma. The PRISMA guidelines were followed to ensure a comprehensive analysis. Results: Out of 63 identified studies, 43 met the inclusion criteria and were reviewed. These studies highlighted the rarity and aggressive behavior of adrenal leiomyosarcoma. Surgical excision remains the cornerstone of treatment, often complemented by adjuvant therapies. The reviewed case involved a 52-year-old woman who underwent a right laparoscopic adrenalectomy for a 9 × 7 × 6 cm grade 3 leiomyosarcoma. Despite subsequent adjuvant chemotherapy, hepatic metastases were detected, illustrating the aggressive nature of the disease. The literature underscores the importance of histopathological analysis and long-term surveillance for managing disease progression. Conclusions: Optimal management of adrenal leiomyosarcoma requires a multidisciplinary approach and meticulous follow-up. The rarity of the disease poses challenges for standardizing treatment, but surgical excision and tailored adjuvant therapies show promise. Further research is essential to refine treatment strategies and improve prognosis for this rare malignancy. [ABSTRACT FROM AUTHOR]

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting the brain and spinal cord. Non-neuronal cells, including macrophages, may contribute to the disruption of motor neurons (MNs), neuromuscular junction dismantling and clinical signs of ALS. Understanding the modality and the effect of MNs–macrophage communication is pivotal. Here, we focus on extracellular vesicle (EVS)-mediated communication and, in particular, we analyze the response of macrophages. NSC-34 cells transfected with mutant SOD1 (G93A, A4V, G85R, G37R) and differentiated towards MN-like cells, and Raw 264.7 macrophages are the cellular models of the study. mSOD1 NSC-34 cells release a high number of vesicles, both large-lEVs (300 nm diameter) and small-sEVs (90 nm diameter), containing inflammation-modulating molecules, and are efficiently taken up by macrophages. RT-PCR analysis of inflammation mediators demonstrated that the conditioned medium of mSOD1 NSC-34 cells polarizes Raw 264.7 macrophages towards both pro-inflammatory and anti-inflammatory phenotypes. sEVs act on macrophages in a time-dependent manner: an anti-inflammatory response mediated by TGFβ firstly starts (12 h); successively, the response shifts towards a pro-inflammation IL-1β-mediated (48 h). The response of macrophages is strictly dependent on the SOD1 mutation type. The results suggest that EVs impact physiological and behavioral macrophage processes and are of potential relevance to MN degeneration. [ABSTRACT FROM AUTHOR]

The School in Hospital represents a structured intervention aimed at ensuring the right to education for all students who, due to specific health conditions, are unable to attend the school. This contribution seeks to foster a critical reflection on the School in Hospital service in Italy and the effectiveness of the care action in a biopsychosocial context. It is realized as an outcome of collaborative work among various professionals engaged in the helping relationship within hospital educational settings. The specific synergistic and trans-disciplinary approach, aimed to contributing to the overcoming of the fragility experienced by young patients due to their vulnerable condition, allows considering School in Hospital as a significant educational opportunity. Starting from theoretical reflections emerging from a research experience in Sicilian hospital schools, this contribution aims to underscore the value of the multidisciplinary intervention in promoting the learning process and enhancing the well-being of hospitalized students. [ABSTRACT FROM AUTHOR]

Yellow fever (YF) vaccination is recommended for persons living in YF-endemic areas as the most effective strategy to reduce the risk for infection (1). The 17D and 17DD live attenuated [...]