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1. ULTRASAT: A Wide-field Time-domain UV Space Telescope

Author: Y. Shvartzvald, E. Waxman, A. Gal-Yam, E. O. Ofek, S. Ben-Ami, D. Berge, M. Kowalski, R. Bühler, S. Worm, J. E. Rhoads, I. Arcavi, D. Maoz, D. Polishook, N. Stone, B. Trakhtenbrot, M. Ackermann, O. Aharonson, O. Birnholtz, D. Chelouche, D. Guetta, N. Hallakoun, A. Horesh, D. Kushnir, T. Mazeh, J. Nordin, A. Ofir, S. Ohm, D. Parsons, A. Pe’er, H. B. Perets, V. Perdelwitz, D. Poznanski, I. Sadeh, I. Sagiv, S. Shahaf, M. Soumagnac, L. Tal-Or, J. Van Santen, B. Zackay, O. Guttman, P. Rekhi, A. Townsend, A. Weinstein, and I. Wold
Subjects: Near ultraviolet astronomy, Space telescopes, Time domain astronomy, Gravitational wave sources, Supernovae, Gamma-ray bursts, Astrophysics, QB460-466
Abstract: The Ultraviolet Transient Astronomy Satellite (ULTRASAT) is scheduled to be launched to geostationary orbit in 2027. It will carry a telescope with an unprecedentedly large field of view (204 deg ^2 ) and near-ultraviolet (NUV; 230–290 nm) sensitivity (22.5 mag, 5 σ , at 900 s). ULTRASAT will conduct the first wide-field survey of transient and variable NUV sources and will revolutionize our ability to study the hot transient Universe. It will explore a new parameter space in energy and timescale (months-long light curves with minutes cadence), with an extragalactic volume accessible for the discovery of transient sources that is >300 times larger than that of the Galaxy Evolution Explorer (GALEX) and comparable to that of the Vera Rubin Observatory’s Legacy Survey of Space and Time. ULTRASAT data will be transmitted to the ground in real time, and transient alerts will be distributed to the community in 23.5 AB mag, over 10 times deeper than the GALEX map. Two key science goals of ULTRASAT are the study of mergers of binaries involving neutron stars, and supernovae. With a large fraction (>50%) of the sky instantaneously accessible, fast (minutes) slewing capability, and a field of view that covers the error ellipses expected from gravitational-wave (GW) detectors beyond 2026, ULTRASAT will rapidly detect the electromagnetic emission following binary neutron star/neutron star–black hole mergers identified by GW detectors, and will provide continuous NUV light curves of the events. ULTRASAT will provide early (hour) detection and continuous high-cadence (minutes) NUV light curves for hundreds of core-collapse supernovae, including for rarer supernova progenitor types.
Published: 2024
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2. Digital Teaching, Inclusion and Students’ Needs: Student Perspectives on Participation and Access in Higher Education

Author: Leevke Wilkens, Anne Haage, Finnja Lüttmann, and Christian R. Bühler
Subjects: accessibility, digital teaching, disability, higher education, icts, impairment, inclusion, universal design, wcag, Sociology (General), HM401-1281
Abstract: In this article we discuss the contribution of digitalisation for equal participation in higher education. Its potential is often postulated, but accessibility is seldom examined in this context. Despite the challenges and difficulties created in the summer term of 2020, this semester has provided a great opportunity to collect data on digital teaching, as face‐to‐face teaching needed to be transformed into digital teaching. Based on two surveys conducted in the summer of 2020, current practices and students’ needs regarding accessibility are outlined. Despite the circumstances, it can be derived from the surveys that digital teaching generally provides a variety of advantages for students with disabilities, although some tools and platforms remain not fully accessible to them. Additionally, the results indicate that not only students with sensory impairments benefit from the principles of the Web Content Accessibility Guidelines (2018). In particular, the principles ‘operable’ and ‘understandable’ are beneficial for students with mental health difficulties. Regarding the assessment of accessibility features, the study shows that the perception of students with and without impairments is very similar.
Published: 2021
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3. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory

Author: Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics
Subjects: Physics, Observatory, Gamma ray, Astronomy
Abstract: Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)
Published: 2022

4. The BioValley Life Sciences Week, Where Biotech and MedTech Met

Author: Christian Suter and Fritz R. Bühler
Subjects: Biovalley life sciences week, Business platform, European pharmacopoeia, Medical technology, Nanosciences, Systems biology, Chemistry, QD1-999
Abstract: For the third time the BioValley Life Sciences Week took place from October 13 to 22, 2004 in the French, German, and Swiss centers of the BioValley Life Sciences Network. Events included a 'Science et Cité' evening in Lörrach about new concepts in cancer management, the Business Platform in Freiburg where Biotech met Pharma, the 'Fête de la Science' in Strasbourg highlighting the challenges for XXIst century research, the BioValley Annual Conference in Colmar where the BioValley profile was discussed, the University Day in Strasbourg presenting the European Pharmacopoeia and looking at Drug Discovery 2004 and a sequence of events in Basel which were attended by more than 1500 persons. Events in Basel included the Science Day on systems biology and nanosciences, the Connect Day which was devoted to Partnering and Financing, the Medtech Day where this less well known but very important industry showed its cutting edge technologies, and finally the BioValley College Day attracting several hundred students from the neighboring high schools of the three countries. The BioValley Life Sciences Week has established itself firmly in the calendar of the region and will be organized again in the fall of 2005.
Published: 2004
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5. Financing, Incubating, Coaching, and the Cluster Effect

Author: Fritz R. Bühler and Christian Suter
Subjects: Biotechnology industry, Cluster effect, Life sciences, Stock exchange, Venture capital, Chemistry, QD1-999
Abstract: More innovation financing, incubating and coaching would be helpful for European biotechnology. Venture capital is available for all stages of biotech company development, providing companies are innovative and of high quality. Several venture funds are active in the BioValley. To compensate for the shortcomings of management experience, a low-cost portfolio of integrated services could be provided by seasoned managers but the system has to be created, managed, and paid for by the small companies. Such shortcomings facing young companies can be overcome by seed financing, incubating and coaching, and providing a dynamic regional biotech/life sciences development organization leading to a cluster effect. This allows much better use of available assets including sparse financial means.
Published: 2004
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6. Capabilities beyond Gamma Rays

Author: R. D. Parsons, R. Bühler, Jim Hinton, K. Egberts, and D. Dravins
Subjects: Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, 522.6862, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Galaxy Astrophysics, ddc:522.6862
Abstract: Science with the Cherenkov Telescope Array; Hackensack : WORLD SCIENTIFIC 291-299 (2019). doi:10.1142/10986, A set of telescope arrays will be built to observe gamma rays, Published by WORLD SCIENTIFIC, Hackensack
Published: 2019

7. Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter

Author: H. Eiffert, Matthias Klein, R. Bühler, H. W. Pfister, J. R. Weber, Bernd Salzberger, Roland Nau, J. Linn, B. Grabein, and Hayrettin Tumani
Subjects: Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Bacterial meningoencephalitis, Medicine, 030208 emergency & critical care medicine, Bacterial meningitis, 030212 general & internal medicine, Neurology (clinical), business, 3. Good health
Abstract: Das Hauptziel dieses Manuskripts war ein Upgrading der DGN-Leitlinie „Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter“ auf ein S2k-Niveau nach den Standards der AWMF. Zehn nominierte Mitglieder der Deutschen Gesellschaft fur Neurologie (DGN), Schweizerischen Neurologischen Gesellschaft (SNG), Osterreichischen Gesellschaft fur Neurologie (OGN), Deutschen Gesellschaft fur Hygiene und Mikrobiologie (DGHM), Paul-Ehrlich-Gesellschaft fur Chemotherapie (PEG), Deutschen Gesellschaft fur Neuroradiologie (DGNR), Deutschen Gesellschaft fur Neurointensiv- und Notfallmedizin (DGNI), Deutschen Gesellschaft fur Infektiologie (DGI), Deutschen Gesellschaft fur Innere Medizin (DGIM) und der Deutschen Gesellschaft fur Liquordiagnostik und Klinische Neurochemie (DGLN) waren an der Formulierung dieser Leitlinie beteiligt. Die Vorstande der Fachgesellschaften stimmten der Leitlinie zu. Die Leitlinie gibt einen Uberblick uber die klinischen Manifestationen und Komplikationen der bakteriellen Meningoenzephalitis im Erwachsenenalter, den notwendigen diagnostischen Schritten, den Therapieempfehlungen und den wichtigsten Praventionsmasnahmen.
Published: 2016

8. Pathophysiology and Clinical Application of the Renin System: Early Steps Toward Personalized Medicine

Author: Fritz R. Bühler
Subjects: business.industry, Pharmacology, History, 20th Century, Bioinformatics, History, 21st Century, Pathophysiology, Renin-Angiotensin System, Translational Research, Biomedical, Renin–angiotensin system, Hypertension, Renin, Internal Medicine, Medicine, Humans, Personalized medicine, Precision Medicine, business
Published: 2017

9. Expanding Boundaries - Matching Renewable Energy Production and Consumption by Market Regulated Demand Site Management (DSM) – T. Schluck, R. Bühler, S. Sulzer, M. Sulzer

Author: R. Bühler, T. Schluck, and S. M. Sulzer
Subjects: Consumption (economics), Matching (statistics), business.industry, Economics, Production (economics), business, Site management, Agricultural economics, Renewable energy
Published: 2016

10. Continuing Medical Education and Professional Development in the European Union

Author: Bernard Maillet, L. Miller, Hervé Maisonneuve, Fritz R. Bühler, Alfonso Negri, Honorio Silva, and Peter Stonier
Subjects: Pharmacology, Further education, Medical education, business.industry, education, Lifelong learning, Professional development, Continuing medical education, Nursing, Pharmaceutical medicine, Medicine, media_common.cataloged_instance, Pharmacology (medical), European union, business, Competence (human resources), media_common, Accreditation
Abstract: Continuing medical education (CME) and its broader term continuing professional development (CPD) are indispensable as part of lifelong learning and may be regarded as equally or more important than undergraduate and postgraduate medical education. Pharmaceutical medicine occupies common ground between the clinical and healthcare professions, pharmaceutical industry and government, and thus, the same principles are applicable. However, the global status of CME/CPD education in pharmaceutical medicine is alarming. Surveys conducted among pharmaceutical medicine associations from 22 countries and pharmaceutical physicians in the US showed that a relatively low number of CME/CPD activities are developed across countries, a high percentage of pharmaceutical physicians lack formal postgraduate education in pharmaceutical medicine and, additionally, training needs in basic knowledge areas were detected. It is evident that further education efforts are necessary. The CME system has many variations across countries. The CME/CPD model, including credits or hours, is the currency by which regulatory bodies often assess competence all over the world. Accreditation systems have been developed primarily in the US and Europe in an attempt to self-regulate and advance practice standards, as well as to respond to environmental pressures for advancement of healthcare quality and insulation of any commercial influence on education. Initiatives for a European and/or global CME harmonization have been developed. However, the major problem is that the various CME systems are very different and fragmented. In spite of the tremendous amount of resources spent on maintaining and upgrading physicians’ knowledge and skills, the effectiveness of CME in producing changes in practice has been questioned. It has been argued that CME programmes, as currently practiced, do not adequately focus on improving clinical performance and patient health outcomes. The emphasis is put on measuring acquired knowledge based on training hours, instead of assessing competences and skills as a result of professional development. A new CME/CPD outcomes-based model for performance improvement through individualized and standardized education has been proposed, including physician’s self-assessment, self-reflection and practice-based learning. PharmaTrain is a public private partnership sponsored by the EU’s Innovative Medicines Initiative including 24 universities, 13 learned societies/associations and several partner training organizations. PharmaTrain aims to provide courses that are designed to meet the needs of pharmaceutical physicians and other professionals working in medicines development (basic diploma, masters and CME/CPD). The PharmaTrain CPD platform will include diploma and master extension and elective modules, both course based and standalone, aimed to facilitate lifelong learning. The successful development and use of the PharmaTrain CPD platform provides a valuable new opportunity to meet the current standards and expectations for CME/CPD posed by stakeholders and society at large.
Published: 2012

11. Hypoxische Enzephalopathie (HE)

Author: B. Voller, R. Bühler, W. von Scheidt, Gerhard F. Hamann, A. Bender, and H. C. Hansen
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Neurology (clinical), business
Abstract: Die hypoxische Enzephalopathie (HE) erfahrt aufgrund des zunehmenden Anteils alterer Menschen in der Bevolkerung und der besseren Reanimationserfolge nach Herz-Kreislauf-Stillstand eine wachsende Bedeutung. Zunehmend mehr Patienten nach kardiopulmonaler Reanimation erreichen die Klinik. Bei Herz-Kreislauf-Stillstand gelten folgende Reanimationsregeln: Der ungeubte Laie soll sich auf eine effektive Herzmassage konzentrieren, ein einheitliches Kompressions-Beatmungs Verhaltnis von 30:2 wird praklinisch vom geubten Helfer bei Erwachsenen wie Kindern verwendet. Die Kompressionsfrequenz betragt 100/min und empfohlen wird die fruhe Defibrillation bei Kammertachykardie/Kammerflimmern. Wird die Klinik erreicht, sollte fur die ersten 24 Stunden mit milder therapeutischer Hypothermie (TH) (32–34 °C) behandelt werden. Hiermit wird eine deutlich bessere Prognose erreicht. Ein wichtiger, neurologischer Aspekt der HE ist die Prognosestellung. Hierbei gilt: Es gibt derzeit keinen einfachen Prognosealgorithmus fur Patienten, die mit TH behandelt wurden. In den ersten 24 Stunden nach Reanimation vermag keine klinische oder technische Testung zuverlassig eine schlechte Prognose vorauszusagen, speziell kein Einzelparameter. Unter den Voraussetzungen eines fehlenden Medikamenteneffekts und einer nicht durchgefuhrten therapeutischen Hypothermie zeigt ein posthypoxisch tiefes Koma mit bis zum Tag 3 anhaltend erloschener Lichtreaktion der Pupille und erloschenem Kornealreflex die schlechte Prognose wahrscheinlich sicher an. Der erloschene okulozephale Reflex nach 24 Stunden und ein GCS Motor-Punktwert unter 3 (d. h. ausgefallene Motorik oder Strecksynergismen) nach 72 Stunden sind weniger verlasslich. Andere klinische Zeichen, einschlieslich des Myoklonus, sind ungeeignet. Der Nachweis des beidseitigen SEP Verlustes innerhalb der Tage 2–3 nach Beginn einer HE spricht unter der Bedingung ausreichender Erfahrung mit der Methode ohne TH fur eine schlechte Prognose. Nach TH ist diese Sicherheit allein aufgrund des kompletten SEP-Ausfalls innerhalb von 3 Tagen nicht gegeben. Die Hohe der NSE-Werte im Serum ist mit dem Ausmas der Hirnschadigung korreliert. Derzeit konnen keine sicheren oberen Grenzwerte, bis zu denen eine Erholung noch moglich ist, definiert werden. Die Zeitintervalle fur die Prognosestellung nach TH mussen verlangert werden und sowohl die klinischen, wie technischen Untersuchungen mit Vorsicht gewichtet werden. In erster Linie wird auf Kongruenz der Untersuchungsergebnisse und Ausschluss von Storfaktoren (z. B. Medikationsuberhang) zu achten sein. Die Konstellation „Ausfall der Lichtreaktionen und der Kornealreflexe oder Motor GCS unter 3 kombiniert mit einem Ausfall bei der N 20 bilateral im Medianus-SSEP oder einem areaktiven EEG nach 3 Tagen weist deutlich auf eine schlechte Prognose hin. Eine uberlebte Reanimation infolge Kammertachykardie/Kammerflimmern stellt nach zerebraler Restitution bei Fehlen einer selbst limitierenden Ursache eine ICD Indikation dar.
Published: 2012

12. Simultaneous HESS and Chandra observations of Sagitarius A$^{\star}$ during an X-ray flare

Author: F. Aharonian, A. G. Akhperjanian, U. Barres de Almeida, A. R. Bazer-Bachi, Y. Becherini, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, I. Braun, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, S. Carrigan, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, M. Dalton, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, I. Jung, K. Katarzyński, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, J. L. Osborne, M. Ostrowski, M. Panter, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, C. van Eldik, G. Vasileiadis, C. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HESS, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), 10859748 - Holleran, Mathew, 12006653 - Venter, Christo, 10179240 - Raubenheimer, Barend Christoffel, 13235176 - Büsching, Ingo, 10065857 - De Jager, Ocker Cornelis, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris
Subjects: [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Event horizon, Astrophysics::High Energy Astrophysical Phenomena, Population, FOS: Physical sciences, Flux, Astrophysics, gamma-rays:observations, 01 natural sciences, law.invention, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Coincident, law, 0103 physical sciences, education, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, individuals: Sgr A* [X-rays], Supermassive black hole, education.field_of_study, 010308 nuclear & particles physics, Astrophysics (astro-ph), observations [gamma rays], Astronomy and Astrophysics, X-rays:individual sources:Sgr A, Particle acceleration, Sagittarius A, Space and Planetary Science, individuals: Sgr $A^{\star }$ [X-rays], Flare
Abstract: The rapidly varying (~10 minute timescale) non-thermal X-ray emission observed from Sgr A* implies that particle acceleration is occuring close to the event horizon of the supermassive black hole. The TeV gamma-ray source HESS J1745-290 is coincident with Sgr A* and may be closely related to its X-ray emission. Simultaneous X-ray and TeV observations are required to elucidate the relationship between these objects. We report on joint H.E.S.S./Chandra observations performed in July 2005, during which an X-ray flare was detected. Despite a factor of 9 increase in the X-ray flux of Sgr A*, no evidence is found for an increase in the TeV gamma-ray flux from this region. We find that an increase in the gamma-ray flux of a factor of 2 or greater can be excluded at a confidence level of 99%. This finding disfavours scenarios in which the keV and TeV emission are associated with the same population of accelerated particles and in which the bulk of the gamma-ray emission is produced within ~10^{14} cm (~100 R_S) of the supermassive black hole., 5 pages, 2 figures
Published: 2008

13. Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis

Author: O. Findling, Johann Sellner, R. Bühler, Isabell Greeve, A. Gebhardt, N. Lüthi, and H. P. Mattle
Subjects: Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Myelitis, Myelitis, Transverse, Gastroenterology, Statistics, Nonparametric, Transverse myelitis, Risk Factors, Internal medicine, medicine, Humans, Family history, Aged, Retrospective Studies, Neurologic Examination, Univariate analysis, Expanded Disability Status Scale, Clinically isolated syndrome, medicine.diagnostic_test, business.industry, Multiple sclerosis, Oligoclonal Bands, Electroencephalography, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Surgery, Neurology, Immunoglobulin G, Disease Progression, Evoked Potentials, Visual, Female, Neurology (clinical), business, Follow-Up Studies
Abstract: Acute partial transverse myelitis (APTM) may be the first clinical manifestation of multiple sclerosis (MS), of relapsing myelitis, or remain a monophasic event. Identification of risk factors associated with relapse or conversion to MS is important, as prognostic information might help to guide management. The objective of this study was to define clinical, laboratory and neuroimaging factors in patients with first-ever APTM that predict relapses or conversion to MS. We identified 73 patients with a first-ever APTM admitted to our institution from January 1999 to June 2005. The follow-up time ranged from 12 to 90 months (mean follow-up 46 months). Patient demographics, clinical impairment at onset and after 3 months, ancillary tests including cerebrospinal fluid (CSF), magnetic resonance imaging (MRI), evoked potentials, recurrent and new symptoms and signs during follow-up were analysed. APTM remained a monophasic event in 35 patients (47.9%), conversion to MS occurred in 32 (43.8%) and recurred as relapsing myelitis in six patients (8.2%). According to univariate analysis, a family history of MS (P = 0.02), higher expanded disability status scale (EDSS) at onset (P = 0.03) and lesions on brain MRI (P = 0.03) were predictive factors for conversion to MS. CSF-specific oligoclonal bands (P = 0.04) or abnormal IgG-index (P = 0.04) were associated with increased risk for MS as well. In patients with a first-ever APTM, a family history of MS, high EDSS at presentation, lesions on brain MRI, CSF-specific oligoclonal bands or abnormal IgG-index may indicate an increased risk for conversion to MS.
Published: 2008

14. Personality and Adrenergic Factors in Essential Hypertension1

Author: C. Perini, Peter Bolli, F. W. Amann, and Fritz R. Bühler
Subjects: business.industry, media_common.quotation_subject, Medicine, Personality, Adrenergic, business, Bioinformatics, Essential hypertension, medicine.disease, media_common
Published: 2015

15. Corrigendum: Core Competencies for Pharmaceutical Physicians and Drug Development Scientists

Author: Joao Massud, Johanna Schenk, Jean P. Deslypere, Rudolf van Olden, Fritz R. Bühler, Gerfried Nell, Greg Koski, Sandor Kerpel-Fronius, Ingrid Klingmann, Peter Stonier, Domenico Criscuolo, Honorio Silva, Norbert Clemens, Gustavo Kesselring, Stewart Geary, and Dominique Dubois
Subjects: medicine.medical_specialty, Alternative medicine, Mistake, Competency based education, medicines development, pharmaceutical physicians, drug development scientists, medicine, Pharmacology (medical), Confusion, Pharmacology, competencies, business.industry, Pharmaceutical medicine, lcsh:RM1-950, Core competency, Data science, learning outcomes, lcsh:Therapeutics. Pharmacology, Drug development, core competencies, Engineering ethics, medicine.symptom, business, Corrigendum
Abstract: The total number of competencies mentioned in the Abstract and pages 4 and 5 of the paper are erroneously reported as 60. The actual number is 57. Apologies for the involuntary mistake and confusion created.
Published: 2015

16. Discovery of the two 'wings' of the Kookaburra complex in VHE γ-rays with HESS

Author: F. Aharonian, A. G. Akhperjanian, A. R. Bazer-Bachi, M. Beilicke, W. Benbow, D. Berge, K. Bernlöhr, C. Boisson, O. Bolz, V. Borrel, I. Braun, A. M. Brown, R. Bühler, I. Büsching, S. Carrigan, P. M. Chadwick, L.-M. Chounet, R. Cornils, L. Costamante, B. Degrange, H. J. Dickinson, A. Djannati-Ataï, L. O'C. Drury, G. Dubus, K. Egberts, D. Emmanoulopoulos, P. Espigat, F. Feinstein, E. Ferrero, A. Fiasson, G. Fontaine, S. Funk, M. Füßling, Y. A. Gallant, B. Giebels, J. F. Glicenstein, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, D. Horns, A. Jacholkowska, O. C. de Jager, E. Kendziorra, B. Khélifi, Nu. Komin, A. Konopelko, K. Kosack, I. J. Latham, R. Le Gallou, A. Lemière, M. Lemoine-Goumard, T. Lohse, J. M. Martin, O. Martineau-Huynh, A. Marcowith, C. Masterson, G. Maurin, T. J. L. McComb, M. de Naurois, D. Nedbal, S. J. Nolan, A. Noutsos, K. J. Orford, J. L. Osborne, M. Ouchrif, M. Panter, G. Pelletier, S. Pita, G. Pühlhofer, M. Punch, B. C. Raubenheimer, M. Raue, S. M. Rayner, A. Reimer, O. Reimer, J. Ripken, L. Rob, L. Rolland, G. Rowell, V. Sahakian, A. Santangelo, L. Saugé, S. Schlenker, R. Schlickeiser, R. Schröder, U. Schwanke, S. Schwarzburg, A. Shalchi, H. Sol, D. Spangler, F. Spanier, R. Steenkamp, C. Stegmann, G. Superina, J.-P. Tavernet, R. Terrier, C. G. Théoret, M. Tluczykont, C. van Eldik, G. Vasileiadis, C. Venter, P. Vincent, H. J. Völk, S. J. Wagner, and M. Ward
Subjects: Point spread function, Physics, Photon, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Cosmic microwave background, Gamma ray, Astronomy and Astrophysics, Radius, Astrophysics, 01 natural sciences, Pulsar, 13. Climate action, Space and Planetary Science, 0103 physical sciences, Light emission, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Cherenkov radiation
Abstract: Aims. Search for Very High Energy gamma-ray emission in the Kookaburra complex through observations with the H.E.S.S. array. Methods. Stereoscopic imaging of Cherenkov light emission of the gamma-ray showers in the atmosphere is used for the reconstruction and selection of the events to search for gamma-ray signals. Their spectrum is derived by a forward-folding maximum likelihood fit. Results. Two extended gamma-ray sources with an angular (68%) radius of 3.3-3.4' are discovered at high (>13sigma) statistical significance: HESS J1420-607 and HESS J1418-609. They exhibit a flux above 1 TeV of (2.97+/-0.18stat +/-0.60sys)x10-12 and (2.17+/-0.17stat +/-0.43sys)x10-12 cm-2 s-1, respectively, and similar hard photon indices ~2.2. Multi-wavelength comparisons show spatial coincidence with the wings of the Kookaburra. Two pulsar wind nebulae candidates, K3/PSR J1420-6048 and the Rabbit, lie on the edge of the H.E.S.S. sources. Conclusions. The two new sources confirm the non-thermal nature of at least parts of the two radio wings which overlap with the gamma-ray emission and establish their connection with the two X-ray pulsar wind nebulae candidates. Given the large point spread function of EGRET, the unidentified source(s) 3EG J1420-6038/GeV J1417-6100 could possibly be related to either or both H.E.S.S. sources. The most likely explanation for the Very High Energy gamma-rays discovered by H.E.S.S. is inverse Compton emission of accelerated electrons on the Cosmic Microwave Background near the two candidate pulsar wind nebulae, K3/PSR J1420-6048 and the Rabbit. Two scenarios which could lead to the observed large (~10 pc) offset-nebula type morphologies are briefly discussed.
Published: 2006

17. IFAPP News

Author: Herman Lahon, Tatyana Maltseva, and Fritz R. Bühler
Subjects: Pharmacology, medicine.medical_specialty, Pharmacotherapy, business.industry, Environmental health, Family medicine, Pharmacology toxicology, Medicine, business
Published: 2003

18. The triple stimulation technique to study central motor conduction to the lower limbs

Author: Kai M. Rösler, André Truffert, Michel R. Magistris, Christian W. Hess, and R Bühler
Subjects: Adult, Male, medicine.medical_specialty, Multiple Sclerosis, medicine.medical_treatment, Neural Conduction, Pyramidal Tracts, Central nervous system disease, Muscular Diseases, Physiology (medical), Internal medicine, medicine, Humans, Motor Neuron Disease, Amyotrophic lateral sclerosis, Muscle, Skeletal, Motor Neurons, Leg, business.industry, Motor control, Middle Aged, Motor neuron, Evoked Potentials, Motor, bacterial infections and mycoses, medicine.disease, Electric Stimulation, Sensory Systems, Motor unit, Transcranial magnetic stimulation, medicine.anatomical_structure, Spinal Cord, Neurology, Corticospinal tract, Cardiology, Female, Neurology (clinical), business, Neuroscience, Motor cortex
Abstract: Objective : To quantify the percentage of motor units of a foot muscle that can be activated by transcranial magnetic stimulation (TMS) in normal subjects and patients. Methods : We adapted the recently described triple stimulation technique (TST) for recordings from abductor hallucis (AH). Conventional motor evoked potentials (MEPs) of this muscle are usually small and variable in shape, because of an important temporal desynchronization of the TMS induced spinal motor neuron discharges. The TST allows ‘resynchronization’ of these discharges and thereby a quantification of the proportion of motor units activated by TMS. The lower limb (LL-) TST was applied to 33 sides of 18 normal subjects and 51 sides of 46 patients with multiple sclerosis, amyotrophic lateral sclerosis, or spinal cord disorders. Results : In healthy subjects, the LL-TST demonstrated that TMS achieves activation of virtually all motor neurons supplying the AH. In 33 of 51 patient sides, abnormal LL-TST responses suggested corticospinal conduction failures of various degrees. The LL-TST was 2.54 times more sensitive to detect central conduction failures than the conventional LL-MEPs. Combining the LL-TST with TST of the upper limbs further increased the sensitivity to detect a conduction failure by 1.50 times. Conclusion : The LL-TST markedly improves the examination of corticospinal pathways.
Published: 2001

19. Insulin - Nebensache oder gar Ursache der Hypertonie?

Author: E. Ritz and F. R. Bühler
Subjects: medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, medicine, General Medicine, business
Published: 2008

20. Frontiers in Hypertension Research

Author: J. H. Laragh, F. R. Bühler, D. W. Seldin, J. H. Laragh, F. R. Bühler, and D. W. Seldin
Subjects: Cardiology, Blood-vessels—Diseases
Abstract: reached full definition in the 1940s by Kempner diet. The important role of adrenal aldosterone and associates in demonstrating the beneficial ef secretion in supporting human hypertension is now fects of a low salt rice diet for treating hypertensive well recognized as are the beneficial effects of patients. It became apparent that the value of rice blockade, especially in low-renin patients who ex was wholly related to its sodium content. A rice hibit inappropriate or absolute excesses of aldoste diet, or any other stringent low sodium diet, rone secretion. Further definition of the more sub greatly improves or completely corrects the hyper tle participation of aldosterone and of the factors tension of about ~ or so of all patients with essen that control aldosterone secretion in hypertensive subjects are promising areas for further research. tial hypertension. However, what is often forgotten is that little or no benefit accrues to the remaining THE NERVOUS SYSTEM majority of patients. Parallel studies of animal models has demon Besides the endocrine and excretory functions of strated the amplifying effect of a high sodium diet the kidney and the influence of dietary sodium on blood pressure and vice versa. Strains of rats and of aldosterone secretion, there has been long were developed which are especially sensitive to standing agreement about the important role of the pressor effects of a high sodium diet. In a way, the nervous system in blood pressure control.
Published: 2012

21. Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique

Author: Dimitri V. Stambolsky, Fritz R. Bühler, Vsevolod A. Tkachuk, Thérèse J. Resink, Valery N. Bochkov, and Maria Philippova
Subjects: Adult, Male, Very low-density lipoprotein, Adolescent, Apolipoprotein B, Polymers, Molecular Sequence Data, Heymann Nephritis Antigenic Complex, Ligands, Biochemistry, Antibodies, Muscle, Smooth, Vascular, Polyamines, Humans, Amino Acid Sequence, Receptors, Immunologic, Scavenger receptor, Receptor, Molecular Biology, Aorta, Receptors, Lipoprotein, Lipoprotein lipase, Membrane Glycoproteins, biology, Cell Membrane, Fatty Acids, Cell Biology, Middle Aged, Ligand (biochemistry), Polyelectrolytes, Molecular biology, Lipoproteins, LDL, Receptors, LDL, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins), Low Density Lipoprotein Receptor-Related Protein-1, Protein Binding, Research Article, Lipoprotein
Abstract: Using ligand blotting techniques, with low-density lipoprotein (LDL) as ligand, we have previously described the existence of atypical lipoprotein-binding proteins (105 kDa and 130 kDa) in membranes from human aortic medical tissue. The present study demonstrates that these proteins are also present in membranes from cultured human (aortic and mesenteric) and rat (aortic) vascular smooth-muscle cells (VSMCs). To assess the relationship of 105 and 130 kDa lipoprotein-binding proteins to known lipoprotein receptors, ligand binding specificity was studied. We tested effects of substances known to antagonize ligand binding to either the LDL [apolipoprotein B,E (apo B,E)] receptor (dextran sulphate, heparin, pentosan polysulphate, protamine, spermine, histone), the scavenger receptor (dextran sulphate, fucoidin), the very-low-density-lipoprotein (VLDL) receptor [receptor-associated protein (RAP)], or LDL receptor-related protein (RAP, alpha 2-macroglobulin, lipoprotein lipase, exotoxin-A). None of these substances, with the exception of dextran sulphate, influenced binding of LDL to either 105 or 130 kDa proteins. Sodium oleate or oleic acid, known stimuli for the lipoprotein binding activity of the lipolysis-stimulated receptor, were also without effect. LDL binding to 105 and 130 kDa proteins was inhibited by anti-LDL (apo B) antibodies. LDL and VLDL bound to 105 and 130 kDa proteins with similar affinities (approximately 50 micrograms/ml). The unique ligand selectivity of 105 and 130 kDa proteins supports the existence of a novel lipoprotein-binding protein that is distinct from all other currently identified LDL receptor family members. The similar ligand selectivity of 105 and 130 kDa proteins suggests that they may represent variant forms of an atypical lipoprotein-binding protein.
Published: 1996

22. Mibefradil Prevents Neointima Formation After Vascular Injury in Rats

Author: R. Schmitt, N. Iberg, Jean-Paul Clozel, and F. R. Bühler
Subjects: Male, Neointima, medicine.medical_specialty, Tetrahydronaphthalenes, chemistry.chemical_element, In Vitro Techniques, Calcium, Muscle, Smooth, Vascular, Calcium in biology, Membrane Potentials, Internal medicine, Animals, Medicine, Rats, Wistar, Cells, Cultured, Mibefradil, Dose-Response Relationship, Drug, Voltage-dependent calcium channel, business.industry, Calcium channel, T-type calcium channel, Calcium Channel Blockers, Rats, Endocrinology, Verapamil, chemistry, Benzimidazoles, Amlodipine, Carotid Artery Injuries, Tunica Intima, Cardiology and Cardiovascular Medicine, business, Cell Division, medicine.drug
Abstract: Abstract Mibefradil is a novel calcium antagonist that is selective for the T-type voltage-operated calcium channel rather than the L type. Because T-type calcium channels are present on rapidly proliferating cells and mediate the increase of intracellular calcium induced by some growth factors, such as platelet-derived growth factor, we hypothesized that the blockade of T channels could prevent the excessive smooth muscle cell proliferation that occurs in conditions such as vascular injury. To test this hypothesis, we evaluated in rats the effects of mibefradil (which blocks both L- and T-type channels) on neointima formation after vascular injury, and we compared them with those of equihypotensive doses of amlodipine and verapamil (which block only L-type channels). Mibefradil (30 mg/kg) decreased the area of neointima formed 14 days after balloon injury by 54% ( P
Published: 1995

23. Endorthelium-modulated proliferation of medial smooth muscle cells: influence of angiotensin II and converting enzyme inhibition

Author: Thérèse J. Resink, R. Schmidt, A. W. A. Hahn, Fritz R. Bühler, and F. Kern
Subjects: medicine.medical_specialty, Endothelium, Angiotensin-Converting Enzyme Inhibitors, Muscle, Smooth, Vascular, Catheterization, In vivo, Internal medicine, medicine.artery, medicine, Organoid, Animals, Aorta, DNA synthesis, business.industry, Angiotensin II, Cilazapril, In vitro, Rats, Organoids, Carotid Arteries, Endocrinology, medicine.anatomical_structure, ACE inhibitor, cardiovascular system, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Cell Division, Thymidine, medicine.drug
Abstract: This study investigated the role of the endothelium and angiotensin II (Ang II) in regulating medial smooth muscle cell (SMC) proliferation. [3H]-thymidine incorporation into medial SMC of rat arteries was examined in vivo, using ballooned rat carotid arteries, as well as in vitro, using cultures of aortic tissue rings (organoids). In vivo, maximal medial [3H]-thymidine incorporation occurred within 3 days post-ballooning. In endothelium-denuded organoids, maximum medial DNA synthesis was achieved after 7 days of culture. [3H]-thymidine-labelling of SMC in intact organoids (with endothelium) increased minimally during culture, indicating that the endothelium provided protection with respect to medial proliferation under basal conditions (culture in the presence of 1% plasma-derived serum). Inclusion of 10(-7) M Ang II significantly elevated medial [3H]-thymidine incorporation above that in control cultures. The stimulatory effect of Ang II was much more pronounced in intact organoids that in endothelium-denuded organoids, indicating synergistic growth regulation by Ang II and endothelium-derived factors. When organoids were cultured in the combined presence of Ang II and the ACE inhibitor cilazaprilat, labelling indices of intact organoids were also significantly increased above control, but to a lower level than those obtained in the presence of Ang II alone. However, for endothelium-denuded organoids, medial [3H]-thymidine incorporation in the combined presence of Ang II and cilazaprilat was not significantly different from that in untreated controls. Thus, cilazaprilat exerts both endothelium-dependent and endothelium-independent negative regulatory effects on medial SMC proliferation.
Published: 1995

24. Functional Aspects of Vascular Tenascin-C Expression

Author: Uwe Jonas, Fritz R. Bühler, Alfred W. A. Hahn, Margret John, Thérèse J. Resink, and Frances Kern
Subjects: Male, endocrine system, medicine.medical_specialty, animal structures, Smooth muscle cell migration, Physiology, Cell Adhesion Molecules, Neuronal, Gene Expression, Tenascin, Rats, Inbred WKY, Muscle, Smooth, Vascular, Focal adhesion, Extracellular matrix, Cell–cell interaction, Rats, Inbred SHR, Internal medicine, Cell Adhesion, medicine, Animals, Humans, Aorta, Extracellular Matrix Proteins, biology, Monocyte, Tenascin C, Arteries, Blotting, Northern, musculoskeletal system, Immunohistochemistry, Angiotensin II, Rats, Cell biology, Endocrinology, medicine.anatomical_structure, embryonic structures, biology.protein, Electrophoresis, Polyacrylamide Gel, Endothelium, Vascular, Cardiology and Cardiovascular Medicine
Abstract: The arterial tenascin C expression in vivo and in vitro has been studied using immunohistochemistry. The functional relevance of localized tenascin C expression was assessed in vitro using various human cell types involved in the progression of vascular disease. Normotensive and hypertensive rats exhibited age-dependent patterns of vascular (aorta) tenascin expression, but the lumen-to-media-directed progression of tenascin induction was accelerated in hypertensive rats. Tenascin-rich neointimal lesions (spontaneous) were observed at branching sites of aorta from aged (80 weeks) hypertensive rats. Subendothelial tenascin foci contained lipid-laden smooth muscle cells and monocytes/macrophages. Medial tenascin foci encaged smooth muscle cells which synthesized DNA. Tenascin was expressed both in vivo and in vitro by endothelial and smooth muscle cells but not by monocytes/macrophages; angiotensin II, oxidized-low density lipoprotein and transforming growth factor beta 1 induced expression of tenascin transcripts and glycoprotein in vitro. Endothelial and smooth muscle cells, but not monocytes, adhered to tenascin substrata. Tenascin reduced focal adhesion integrity in confluent endothelial and smooth muscle cell cultures. Angiotensin II-induced migration of endothelial and smooth muscle cells was accompanied by tenascin deposition within extracellular matrix migration trails. Tenascin may function both as a defense against monocyte invasion and medial smooth muscle replication, as well as a substratum for directed endothelial and smooth muscle cell migration.
Published: 1995

25. Denitrification in secondary clarifiers

Author: H. Siegrist, R. Rufer, C. Röck, P. Krebs, R. Bühler, and I. Purtschert
Subjects: Scraper site, Denitrification, Activated sludge, Environmental Engineering, Volume (thermodynamics), Sedimentation (water treatment), Chemistry, Environmental engineering, Nitrification, Anoxic waters, Clarifier, Water Science and Technology
Abstract: Denitrification in secondary clarifiers is primarily due to hydrolysis of particulate degradable COD and decay of biomass. The reduction factor of these processes under anoxic as compared to aerobic conditions was investigated in the treatment plants of the City of Zurich. The Zürich-Glatt plant has circular clarifiers with central inlet. The treatment plant Zürich-Werdhölzli has rectangular clarifiers with cross flow and scrapers with vacuum removal of the sludge. At Zürich Glatt denitrification capacity in the clarifiers was 30% of total denitrification, whereas at Zürich-Werdhölzli only 15 % was observed. The sludge mass in the secondary clarifier depends on inlet flow, return sludge flow, activated sludge concentration, sedimentation properties of the sludge and scraper intervals. During dry weather and due to good sedimentation properties the activated sludge blanket in the thickening zone of the rectangular clarifiers at Zürich-Werdhölzli is almost completely removed after passage of the scraper. Denitrification volume in the secondary clarifier can therefore be modelled in relation to the ratio of inlet to return sludge flow and scraper interval. With the aid of control of return sludge flow and scraper intervals denitrification capacity in the secondary clarifiers may be improved. In order to control denitrification in the secondary clarifier the model must include a variable sludge volume in the clarifier related to scraper interval under the assumption of constant sludge mass in the entire system.
Published: 1995

26. Dioxin emissions from wood combustion

Author: R. Bühler, B. Schatowitz, F. Gafner, P. Hasler, T. Nussbaumer, G. Brandt, and E. Schlumpf
Subjects: Wood waste, Household waste, Environmental Engineering, Waste management, Chemistry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Air pollution, General Medicine, General Chemistry, Combustion, medicine.disease_cause, Pollution, visual_art, visual_art.visual_art_medium, medicine, Environmental Chemistry, Charcoal, Polychlorinated dibenzofurans
Abstract: The emissions of polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) from combustion of different kinds of wood have been determined. Emissions from natural beech wood sticks (0.019 to 0.064 ng TE/m3), natural wood chips (0.066 to 0.214 ng TE/m3) and uncoated chipboard chips (0.024 to 0.076 ng TE/m3) were low, whereas the combustion of waste wood chips resulted in higher dioxin emissions (between 2.70 and 14.42 ng TE/m3). Additionally, two specific fuels were investigated: charcoal and household waste. Charcoal used for grilling of meat resulted in the very low PCDD/PCDF emissions of 0.028 ng TE/m3, whereas the emissions from the combustible part of household waste were very high (114 ng TE/m3). Based on the specific dioxin emissions per kg of fuel, the annual emissions from combustion of wood and the specific fuels were calculated in Switzerland to be 6.9 to 43.8 g TE.
Published: 1994

27. Inactivation of the Na,K-ATPase by radiation-induced free radicals Evidence for a radical-chain mechanism

Author: K. Hitschke, G. Stark, Hans-Jürgen Apell, and R. Bühler
Subjects: Ionizing radiation, Radical, Biophysics, Photochemistry, Biochemistry, D-1, chemistry.chemical_compound, Free radical, Structural Biology, Genetics, Formate, Na+/K+-ATPase, Molecular Biology, chemistry.chemical_classification, Enzymatic activity, Hydroxyl Radical, Butanol, Cell Membrane, Inverse dose rate effect, Water, Dose-Response Relationship, Radiation, Free Radical Scavengers, Cell Biology, Enzyme, chemistry, Na,K-ATPase, Radiolysis, Sodium-Potassium-Exchanging ATPase
Abstract: Free radicals produced by water radiolysis were used to study the inactivation of the enzymatic activity of the Na,K-ATPase. A decrease of the activity to virtually zero with a mono-exponential dependence on the radiation dose was observed. The inactivation process is initiated by hydroxyl radicals. This was shown by the effect of appropriate radical scavengers such as t -butanol, formate and vitamin C. In all cases a significant increase in the characteristic D 37 dose of inactivation was observed. Inactivation was found to show a so-called inverse dose-rate effect, i.e, the sensitivity of the enzyme to radical attack is increased if the dose rate is reduced. The data were found to agree with the relationship 1/ D 37 1/ D 1/2, which is known to be a strong indicator of a radical chain mechanism. This means that the inactivation, after initiation by single radicals, is amplified by a subsequent chain mechanism.
Published: 1994

28. Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers

Author: L Linder, M. Pfisterer, Wolfgang Kiowski, F Burkart, F. R. Bühler, K Stoschitzky, and D Burckhardt
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Endothelium, Vasodilation, Arginine, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Reference Values, Physiology (medical), Internal medicine, medicine, Humans, Endothelial dysfunction, omega-N-Methylarginine, business.industry, Endothelins, Smoking, Middle Aged, medicine.disease, Endothelin 1, Vasomotor System, Endocrinology, medicine.anatomical_structure, chemistry, Vasoconstriction, Anesthesia, Vascular resistance, Blood Vessels, Endothelium, Vascular, Sodium nitroprusside, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: BACKGROUND Smoking is a major risk factor for the development of atherosclerosis. Because endothelial dysfunction may be a marker for future atherosclerosis, we investigated the effects of smoking on endothelium-dependent control of vascular tone. METHODS AND RESULTS The effects of brachial arterial infusions of NG-monomethyl-L-arginine (L-NMMA), a nitric oxide synthesis inhibitor; sodium nitroprusside; endothelin-1; and norepinephrine on forearm blood flow (strain-gauge plethysmography) were compared in 29 long-term smokers and 16 nonsmokers. The acute effects of smoking on systemic hemodynamics, plasma catecholamines, and forearm vascular responses to these compounds were investigated in smokers only. Smokers did not differ from nonsmokers (n = 16) regarding the vascular effects of sodium nitroprusside (n = 13) or vasoconstriction due to norepinephrine and endothelin-1 (n = 16). Low-dose endothelin-1-induced vasodilation, believed to reflect endothelial prostacyclin or nitric oxide release, was absent in smokers (n = 16), and their increase of forearm vascular resistance (FVR) after L-NMMA (n = 13) was impaired (35.6 +/- 27.9% versus 118.8 +/- 43.2%, P < .001). Short-term smoking (n = 11) increased blood pressure, heart rate, and plasma epinephrine concentrations (P < .05 or less); enhanced endothelin-1-induced vasoconstriction (delta FVR, 457 +/- 192% versus 254 +/- 143%, P < .01); and decreased norepinephrine-induced vasoconstriction (P < .05), but had no effect on the other interventions. CONCLUSIONS Long-term smoking is associated with a diminished nitric oxide-dependent component of basal vascular tone and an impaired endothelium-dependent vasodilator response to low-dose endothelin-1 and short-term smoking enhances endothelin-1-induced vasoconstriction. Impaired endothelial control of vascular tone might reflect impairment of normal antiatherosclerotic endothelial functions in smokers, but the relevance of smoking-induced enhancement of endothelin-1 vasoconstriction remains to be determined.
Published: 1994

29. Angiotensin-II-Induced Expression of Laminin Complex and Laminin A-Chain-Related Transcripts in Vascular Smooth Muscle Cells

Author: Fritz R. Bühler, Stephan Regenass, Thérèse J. Resink, Alfred W. A. Hahn, and Frances Kern
Subjects: Male, Teratocarcinoma, Vascular smooth muscle, Transcription, Genetic, Physiology, Blotting, Western, Muscle, Smooth, Vascular, Mice, Laminin, Rats, Inbred SHR, Tumor Cells, Cultured, Protein biosynthesis, Animals, Myocyte, RNA, Messenger, Laminin complex, Aorta, Cells, Cultured, Messenger RNA, Dose-Response Relationship, Drug, biology, Chemistry, Blotting, Northern, Immunohistochemistry, Precipitin Tests, Molecular biology, Angiotensin II, Rats, Organoids, Gene Expression Regulation, Cell culture, Protein Biosynthesis, biology.protein, Endothelium, Vascular, DNA Probes, Cardiology and Cardiovascular Medicine
Abstract: Laminin, a major structural glycoprotein complex of basement membranes has been found to be modulated by angiotensin II in vitro and in vivo. In cultures of aortic organoids and vascular smooth muscle cells, expression of laminin was stimulated by exogenous vasoconstrictor peptide. Stimulation of laminin protein and mRNA expression was observed for both laminin B1/B2-chains and an unknown laminin heavy chain. Compared with PYS-2 cells, a mouse teratocarcinoma cell line which constitutively expresses a 10-kb mRNA transcript for 'classical' laminin A-chain, cultured vascular smooth muscle cells (VSMC) did not express a corresponding mRNA. However, cultured VSMC were found to express laminin A-chain-related mRNAs of approximately 1.8 kb and approximately 3.8 kb, respectively. The 1.8-kb species of transcript was expressed in a constitutive manner, whereas the 3.8-kb mRNA was found to be regulated by angiotensin II. Laminin complexes secreted by cultured cells contained a approximately 300 kD heavy chain which did not immunoreact with immunoreagents raised against either the classical laminin complex secreted by EHS tumor cells or the merosin heavy chain. The putative A-chain analogue possibly represents a new form of a tissue-specific laminin heavy chain, distinct from the A- and M-chains thus far described. Translation products encoded by the A-chain-related transcripts of cultured smooth muscle cells could not be specified using currently available antibodies. The putative protein(s) is speculated to contain the biological features of the N-terminus of the laminin A-chain, namely self-assembly and association with collagen type IV.
Published: 1994

30. Ungewöhnlich schwache Beine?

Author: L Kappeler, H Borer, R Zahnd, and R Bühler
Published: 2011

31. Concerted effects of lipoproteins and angiotensin II on signal transduction processes in vascular smooth muscle cells

Author: Valery N. Bochkov, Fritz R. Bühler, Alfred W. A. Hahn, Thérèse J. Resink, Vsevolod A. Tkachuk, and J. Bernhardt
Subjects: medicine.medical_specialty, Vascular smooth muscle, Inositol Phosphates, Lipoproteins, Biology, Muscle, Smooth, Vascular, chemistry.chemical_compound, Rats, Inbred SHR, Internal medicine, medicine, Animals, Inositol, Inositol phosphate, Cells, Cultured, chemistry.chemical_classification, Phospholipase C, Angiotensin II, Rats, Endocrinology, chemistry, cardiovascular system, Calcium, lipids (amino acids, peptides, and proteins), Signal transduction, Cardiology and Cardiovascular Medicine, Intracellular, Signal Transduction, Lipoprotein
Abstract: Low-density (LDL) and high-density (HDL3) lipoproteins dose-dependently activate phosphoinositide turnover and elevate cytosolic free Ca2+ concentrations ([Ca2+]i) in cultured vascular smooth muscle cells (VSMCs) from either human (microarterioles and aorta) or rat (aorta) sources. High-performance liquid chromatography analysis of cell extracts revealed comparable spectra of inositol phosphate isomers generated in response to either LDL, HDL3, or angiotensin II (Ang II). Thus, lipoproteins and Ang II may use similar, if not identical, signal transduction pathways for the generation and metabolism of inositol phosphates and intracellular Ca2+ mobilization in VSMCs. When Ang II was added in combination with either LDL or HDL3, the phosphoinositide and [Ca2+]i responses of VSMCs were either equal to or even greater than the sum of the effects elicited by the agonists individually. This additivity/synergy between Ang II and the lipoproteins was not accompanied by alteration in the half-maximally effective dose requirements of VSMCs for either Ang II (approximately 2 nmol/L, with or without lipoproteins) or lipoproteins (approximately 50 micrograms/mL for LDL and HDL3, with or without Ang II). Neither short-term (up to 10 minutes) nor long-term (48 hours) exposure of VSMCs to lipoproteins caused desensitization of phospholipase C and intracellular Ca2+ mobilization responses to either Ang II or lipoproteins. Since constant exposure of VSMCs to lipoproteins is a physiological circumstance, and because elevation of [Ca2+]i and activation of phosphoinositide turnover are pivotal events for VSMC contraction and growth, we suggest that the low concentrations of lipoproteins in the vessel intima may play an important role in regulating the response of the vasculature to Ang II.
Published: 1993

32. Ischemic ECG changes are found more often in asymptomatic men with a coronary prone behaviour pattern

Author: Peter Bolli, Charles Perini, K. Bättig, Rico Nil, and Fritz R. Bühler
Subjects: Adult, Male, medicine.medical_specialty, Personality Inventory, Myocardial Infarction, Myocardial Ischemia, Disease, Asymptomatic, Sudden death, Electrocardiography, Risk Factors, Internal medicine, medicine, Humans, cardiovascular diseases, Family history, Risk factor, medicine.diagnostic_test, business.industry, Type A Personality, Type A and Type B personality theory, Middle Aged, Surgery, Psychiatry and Mental health, Clinical Psychology, Blood pressure, Cardiology, Disease Susceptibility, medicine.symptom, Arousal, business
Abstract: Type A behaviour has been related to coronary heart disease (CHD) as an independent risk factor. Therefore, ischemic electrocardiographic (ECG) changes may be more prominent in Type A than in Type B individuals. ECG abnormalities were assessed by the Cardiac Infarction Injury Score (CIIS), which has predictive power for sudden death. In 100 healthy men aged 30–45 yr, the CIIS was related to cardiovascular risk factors such as age, blood pressure, smoking, family history of CHD and behaviour pattern groups defined by the Structured Interview (46 Type A, 20 Type X and 34 Type B subjects). The distribution of the CIIS was different among the behaviour pattern groups (p< 0.05) and was shifted towards higher ischemic scores in Type A subjects. These findings suggest that clinically asymptomatic persons with Type A behaviour have a greater probability of suffering ischemic heart disease and possible sudden death.
Published: 1993

33. Expression of Soluble and Insoluble Fibronectin in Rat Aorta: Effects of Angiotensin II and Endothelin-1

Author: Fritz R. Bühler, Thérèse J. Resink, Frances Kern, Alfred W. A. Hahn, and S. Regenass
Subjects: Male, medicine.medical_specialty, Vascular smooth muscle, Cell, Biophysics, Gene Expression, Biochemistry, Muscle, Smooth, Vascular, Extracellular matrix, Rats, Inbred SHR, Internal medicine, Gene expression, medicine, Organoid, Animals, RNA, Messenger, Molecular Biology, Aorta, Cells, Cultured, biology, Angiotensin II, Endothelins, Cell Biology, Endothelin 1, Molecular biology, Extracellular Matrix, Fibronectins, Rats, Fibronectin, medicine.anatomical_structure, Endocrinology, cardiovascular system, biology.protein
Abstract: This study has investigated the influence of the vasoconstrictor peptides angiotensin II (Ang II) and endothelin-1 (ET-1) on fibronectin expression by vascular smooth muscle cells (VSMC). In confluent, quiescent cultures of VSMC, Ang II and ET-1 elevated fibronectin mRNA levels in a time- and dose-dependent fashion. ET-1 and Ang II also induced a time-dependent expression of immunoreactive fibronectin in cultures of aortic organoids, and for both peptides the fibronectin immunoreactivity was most prominent within those medial smooth muscle cell layers close to the vessel lumen. Immunoprecipitation of biosynthetically labelled fibronectin elaborated by cultured VSMC revealed a predominant expression of soluble fibronectin in response to Ang II, whereas for ET-1 the newly synthesized fibronectin was predominantly incorporated into the extracellular matrix deposit of the cells. These findings indicate that Ang II and ET-1 may exert disparate effects on smooth muscle cell phenotype and migration.
Published: 1993

34. Evidence for the Involvement of G Proteins in the Modulation of 22Na and 45Ca Fluxes in Myogenic L6 and Aortic Smooth Muscle Cells

Author: Sergei N. Orlov, O. Hänninen, Fritz R. Bühler, I.A. Kolosova, J. Bernhardt, and Chandan K. Sen
Subjects: medicine.medical_specialty, Erythrocytes, Vascular smooth muscle, GTP', G protein, Biophysics, Diaphragm pump, In Vitro Techniques, Biology, Biochemistry, Muscle, Smooth, Vascular, Chlorides, GTP-Binding Proteins, Internal medicine, medicine, Aluminum Chloride, Animals, Myocyte, Aluminum Compounds, Molecular Biology, Cells, Cultured, Muscles, Sodium, Skeletal muscle, Biological Transport, Cell Biology, Rubidium, Rats, Red blood cell, medicine.anatomical_structure, Endocrinology, Cell culture, Sodium Fluoride, Calcium, Aluminum
Abstract: Preincubation of rat skeletal muscle derived L6 myoblasts with 10 mM NaF increased, the activity of Na+/H+ exchanger, and the uptake of 45Ca by 2 and 5 folds, respectively. In cultured vascular smooth muscle cells (CVSMC) of rat aorta, NaF increased the activity of Na+ ,K+-pump, Na+/H+ exchanger, passive permeability for Na+, and 45Ca uptake by 1.6, 9, 2, and 9 folds, respectively. Both, in CVSMC and L6 cells, the effect of NaF on the Na+/H+ exchanger and 45Ca uptake were significantly augmented by 20 μM AlCl3. No effect of AlCl3 on the NaF dependent changes in ion flux was seen in rat erythrocytes. The results suggest that in L6 and CVSMC cells, the Na+/H+ exchanger and Ca++ uptake pathway(s) are activated by GTP-binding proteins.
Published: 1993

35. Vascular smooth muscle cell calcium fluxes. Regulation by angiotensin II and lipoproteins

Author: Fabrizia Ferracin, J. Bernhardt, Thérèse J. Resink, Fritz R. Bühler, and Sergei Orlov
Subjects: medicine.medical_specialty, Vascular smooth muscle, Cations, Divalent, Lipoproteins, chemistry.chemical_element, Calcium, Rats, Inbred WKY, Muscle, Smooth, Vascular, Calcium in biology, Nifedipine, Lanthanum, Rats, Inbred SHR, Internal medicine, Internal Medicine, medicine, Animals, Diltiazem, Cells, Cultured, Dose-Response Relationship, Drug, Chemistry, Angiotensin II, Intracellular Membranes, musculoskeletal system, Rats, Kinetics, medicine.anatomical_structure, Endocrinology, cardiovascular system, Intracellular, medicine.drug, Blood vessel
Abstract: This study examined 45Ca uptake, 45Ca efflux, and the distribution of exchangeable 45Ca in confluent, quiescent cultures of aortic smooth muscle cells (VSMCs) from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). These parameters were investigated under basal conditions and after addition of angiotensin II (Ang II) and low (LDL) and high (HDL) density lipoproteins. Basal 45Ca uptake was approximately 50% greater in VSMCs from SHRs (p < 0.005 versus WKY). Calcium antagonists (diltiazem or nifedipine) abolished this difference. The 45Ca uptake response to Ang II was approximately twofold greater in SHR than in WKY VSMCs (p < 0.05), and Ang II-induced increments of 45Ca uptake were weakly inhibited (by approximately 15-25%) by calcium antagonists. Lipoproteins also stimulated 45Ca uptake in VSMCs, and the apparent affinity of this process was approximately fivefold greater for LDL than for HDL. Calcium antagonists did not inhibit either LDL- or HDL-induced 45Ca uptake. SHR and WKY VSMCs did not differ with respect to 45Ca uptake induced by either LDL or HDL. The initial size of the slowly exchangeable pool of intracellular Ca2+ was approximately 35% greater in SHR VSMCs (p < 0.05 versus WKY). Ang II-induced mobilization of intracellular calcium (measured as the decrease in 45Ca content of the slowly exchangeable pool) was threefold greater in SHR VSMCs (p < 0.005 versus WKY). LDL and HDL marginally stimulated 45Ca efflux from this pool (< or = 20% above control) and to comparable extents in both SHR and WKY VSMCs.(ABSTRACT TRUNCATED AT 250 WORDS)
Published: 1993

36. Search for Quantum Gravity induced effects with PKS 2155-304 flaring period in 2006 by H.E.S.S

Author: A. Jacholkowska, J. Bolmont, S. J. Wagner, and R. Bühler
Subjects: PKS 2155-304, Physics, Photon, Active galactic nucleus, law, Astrophysics::High Energy Astrophysical Phenomena, Quantum gravity, Astrophysics, Symmetry breaking, Quantum field theory, Light curve, Flare, law.invention
Abstract: Highly energetic, variable and distant sources such as Active Galactic Nuclei provide a good means to evaluate effects due to the emission and the propagation of high energy photons. In this work, studies of possible energy‐dependent time‐lags with PKS 2155‐304 light curve as measured by H.E.S.S. on 28 July 2006 (MJD 52944) are presented. The time‐lags could come from the emission processes and also sign a Lorentz Symmetry breaking as predicted in some Quantum Gravity models. After a brief description of the methods in use, the latest results from two different analyses of the flare will be given.
Published: 2010

37. Vasoactive Peptides and Growth Factors in the Pathophysiology of Hypertension

Author: Timothy Scott-Burden, Alfred W. A. Hahn, Fritz R. Bühler, and Thérèse J. Resink
Subjects: Pharmacology, Cardiology and Cardiovascular Medicine
Published: 1992

38. Intraluminal Pressure Modulates Vascular Contractility of Perfused Mesenteric Resistance Arteries

Author: Andreas Bock, Michael A Thiel, Fritz R. Bühler, and Thomas F. Lüscher
Subjects: Vascular contractility, medicine.medical_specialty, Contraction (grammar), business.industry, Contractile response, Vasomotion, Microcirculation, Blood pressure, Endocrinology, Internal medicine, Intraluminal pressure, Internal Medicine, medicine, medicine.symptom, business, Muscle contraction
Abstract: Intraluminal pressure may affect vascular contractility in both normotension and hypertension. To test this hypothesis, we studied mesenteric resistance arteries from normotensive humans as well as normotensive (WKY) and spontaneously hypertensive (SHR) rats (internal diameter 214 +/- 27, 201 +/- 6, and 172 +/- 6 microns, mean +/- SEM at 10 mm Hg). Vessels were mounted on glass cannulas and perfused in organ chambers filled with buffer solution at intraluminal pressures of 10 to 120 mm Hg; vasomotion was measured using a video dimension analyzer. Under baseline conditions (10 mm Hg), wall thickness was 36 +/- 4 microns in humans, 32 +/- 4 microns in WKY, and 47 +/- 2 microns in SHR (P less than .001). With increasing pressure, the diameter of human vessels increased up to 25 mm Hg and remained constant at higher pressures. In contrast, resistance arteries of normotensive and hypertensive rats exhibited an almost linear increase in diameter over the whole pressure range. In SHR, the pressure-diameter relationship was much flatter than that of WKY, indicating reduced compliance. In human arteries, the contraction to KCl was maximal at 25 mm Hg and averaged 40 +/- 6%. Both above and below 25 mm Hg, the response declined to a minimum of 17 +/- 2% at 120 mm Hg (P less than .01). Similar results were obtained in WKY rats. In contrast, the contractile response in SHR remained maximal over the entire pressure range studied (65 +/- 5%).(ABSTRACT TRUNCATED AT 250 WORDS)
Published: 1992

39. Effects of Endothelin-1 on Vascular Smooth Muscle Cell Phenotypic Differentiation

Author: Frances Kern, Thérèse J. Resink, Alfred W. A. Hahn, and Fritz R. Bühler
Subjects: medicine.medical_specialty, Vascular smooth muscle, Cell, Fluorescent Antibody Technique, Biology, Muscle, Smooth, Vascular, Paracrine signalling, Transforming Growth Factor beta, In vivo, Internal medicine, medicine, Animals, Cells, Cultured, Actin, Platelet-Derived Growth Factor, Pharmacology, Endothelins, Cell Cycle, Cell Differentiation, Blotting, Northern, Precipitin Tests, Endothelin 1, Actins, In vitro, Rats, Endocrinology, medicine.anatomical_structure, Cardiology and Cardiovascular Medicine, Blood vessel
Abstract: Endothelin-1 (ET-1) produced by vascular endothelial cells has been proposed to act in a paracrine manner on adjacent smooth muscle cells (SMCs) in vivo, exerting a variety of short- and long-term effects. Although some of the in vitro ET-1-mediated effects are related to growth-promoting events, the physiological significance of these observations remains to be clarified. Reported discrepancies of the mitogenic potential of ET-1 may relate to differences in culturing conditions (submitogenic levels of serum in combination with ET-1). Because ET-1 has been implicated in proliferation of vascular SMCs (VSMCs) at sites of vascular injury, as well as pathological events during atherogenesis, a clarification of the mitogenic effects of ET-1 is important. This study demonstrates the possible autocrine role for ET-1 in the regulation of the vasculature, its influence on VSMC cell cycle, and autocrine and phenotypic regulation of VSMCs. Stimulation of quiescent VSMCs with a variety of peptides resulted in the secretion of biologically active ET-1 by VSMCs. In contrast to previous reports, long-term exposure (12-15 days) of VSMCs to ET-1 in nonmitogenic medium did not promote cycling of cells. On the contrary, ET-1 attenuated the cycling of VSMCs in the S and G2/M phases and interrupted progression through the cell cycle at late G1/early S phase. Subsequent to ET-1 exposure, VSMCs expressed increased levels of smooth muscle-specific alpha-actin. Therefore, autocrine-produced ET-1 may contribute to phenotypic differentiation of VSMCs.
Published: 1992

40. Oxidized low density lipoproteins stimulate phosphoinositide turnover in cultured vascular smooth muscle cells

Author: Vsevolod A. Tkachuk, Thérèse J. Resink, Fritz R. Bühler, and J. Bernhardt
Subjects: medicine.medical_specialty, Vascular smooth muscle, Phospholipase, Biology, Phosphatidylinositols, Endocytosis, Second Messenger Systems, Muscle, Smooth, Vascular, chemistry.chemical_compound, Internal medicine, Cyclic AMP, medicine, Humans, Inositol phosphate, Cyclic GMP, Cells, Cultured, Foam cell, chemistry.chemical_classification, Calcium Channel Blockers, Lipoproteins, LDL, Endocrinology, chemistry, Type C Phospholipases, Second messenger system, Phorbol, Tetradecanoylphorbol Acetate, lipids (amino acids, peptides, and proteins), Receptor clustering, Cardiology and Cardiovascular Medicine, Oxidation-Reduction
Abstract: Atherogenesis is associated with alterations in the properties of different cell types, including monocytes/macrophages (foam cell formation), platelets (increased aggregation), endothelial cells (injury), and smooth muscle cells (SMCs) (lipid accumulation or foam cell formation). Oxidized low density lipoproteins (ox-LDL) play a key role in this vascular pathology. This study investigated the ability of ox-LDL to elicit chemical signaling events in cultured human vascular smooth muscle cells (VSMCs). Ox-LDL was found to stimulate phospholipase C-mediated phosphoinositide turnover in human VSMCs. This response occurred rapidly (within 1 minute) and at low concentrations of ox-LDL (half-maximal effective concentration, approximately 5 micrograms/ml). Ox-LDL-stimulated inositol phosphate accumulation in human VSMCs was inhibited by pretreatment of cells with phorbol 12-myristate 13-acetate and with compounds that elevate cyclic AMP or cyclic GMP. Ca2+ antagonists also blocked the effects of ox-LDL on phosphoinositide turnover. Inhibitors of receptor-endocytotic processes (including receptor clustering, cross-linking, and cytoskeleton-dependent internalization) effectively prevented ox-LDL-induced inositol phosphate generation. The data suggest that ox-LDL promotes phospholipase C-mediated phosphoinositide turnover in a manner analogous to that for other Ca(2+)-mobilizing hormones. The results also support an association between phosphoinositide turnover and receptor-mediated endocytosis. Prevention of the direct effects of ox-LDL on SMCs could prove an interesting therapeutic avenue for the prevention of atherosclerosis.
Published: 1992

41. Blood pressure control by the renin-angiotensin system in normotensive subjects. Assessment by angiotensin converting enzyme and renin inhibition

Author: C Kleinbloesem, Wolfgang Kiowski, Lilly Linder, P van Brummelen, and Fritz R. Bühler
Subjects: Adult, Male, medicine.medical_specialty, Captopril, medicine.drug_class, Bradykinin, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Renin inhibitor, Plasma renin activity, Renin-Angiotensin System, chemistry.chemical_compound, Double-Blind Method, Reference Values, Physiology (medical), Internal medicine, Renin, Renin–angiotensin system, Blood plasma, medicine, Humans, biology, business.industry, Hemodynamics, Imidazoles, Angiotensin-converting enzyme, Endocrinology, Blood pressure, chemistry, biology.protein, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: BACKGROUND The participation of the renin-angiotensin system in the control of blood pressure in normal, sodium-replete subjects is not clear. The use of a specific inhibitor of human renin should allow a better delineation of the importance of this system. METHODS AND RESULTS Blood pressure responses were measured 1 hour after randomized, double-blind administration of the renin inhibitor Ro 42-5892 (600 mg p.o.) or the angiotensin converting enzyme inhibitor captopril (50 mg p.o.) in 20 healthy men on an ad libitum sodium diet. Effective inhibition of the renin-angiotensin system by either compound was indicated by increases of immunoreactive renin associated with an increase of angiotensin I production rate of 67.8 +/- 33.6% after captopril and a decrease of 79.5 +/- 16.4% after Ro 42-5892. Furthermore, Ro 42-5892 decreased plasma renin activity by 64%. Whereas intra-arterial diastolic (60 +/- 5.1 to 51.4 +/- 7.2 mm Hg, p less than 0.01) and mean arterial (77.7 +/- 6.0 to 71.4 +/- 8.5 mm Hg, p less than 0.001) pressures decreased after captopril, they remained unchanged after Ro 42-5892. Captopril, but not Ro 42-5892, increased forearm blood flow (2.4 +/- 0.8 versus 1.9 +/- 0.8 ml/min/100 ml, p less than 0.01) and significantly enhanced the increase of forearm blood flow to brachial artery infusions of bradykinin (0.15, 1.5, 5, 15, and 50 ng/min/100 ml; 5 minutes each) from 744 +/- 632% to 1,383 +/- 514% (p less than 0.01). Furthermore, repeat bradykinin infusions resulted in further decreases of blood pressure (from mean pressure of 71.4 +/- 8.5 to 63.2 +/- 7.6 mm Hg, p less than 0.01) only after captopril. Changes of blood pressure after captopril were unrelated to baseline plasma renin activity but correlated with captopril-induced enhancement of vasodilation to bradykinin (r = 0.68, p less than 0.05). CONCLUSIONS The lack of blood pressure effects of renin inhibition in contrast to angiotensin converting enzyme inhibition suggests that the renin-angiotensin system does not contribute significantly to blood pressure control in normotensive, sodium-replete subjects. The hypotensive activity of angiotensin converting enzyme inhibitors may result from additional hormonal effects, for example, inhibition of bradykinin degradation and/or subsequent increases of vasodilating prostaglandins or endothelium-derived relaxing factor(s).
Published: 1992

42. HESS observations of $\gamma$-ray bursts in 2003-2007

Author: F. Aharonian, A. G. Akhperjanian, U. Barres de Almeida, A. R. Bazer-Bachi, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, I. Braun, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, S. Carrigan, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, M. Dalton, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, I. Jung, K. Katarzyński, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, J. L. Osborne, M. Ostrowski, M. Panter, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, C. van Eldik, G. Vasileiadis, C. Venter, L. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, and A. Zech
Subjects: Physics, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Flux, bursts [gamma rays], observations [gamma rays], Astronomy and Astrophysics, Astrophysics, Photon energy, 01 natural sciences, Redshift, Space and Planetary Science, 0103 physical sciences, Background light, Gamma-ray burst, 010303 astronomy & astrophysics, Cherenkov radiation
Abstract: Very-high-energy (VHE; >~100 GeV) gamma-rays are expected from gamma-ray bursts (GRBs) in some scenarios. Exploring this photon energy regime is necessary for understanding the energetics and properties of GRBs. GRBs have been one of the prime targets for the H.E.S.S. experiment, which makes use of four Imaging Atmospheric Cherenkov Telescopes (IACTs) to detect VHE gamma-rays. Dedicated observations of 32 GRB positions were made in the years 2003-2007 and a search for VHE gamma-ray counterparts of these GRBs was made. Depending on the visibility and observing conditions, the observations mostly start minutes to hours after the burst and typically last two hours. Results from observations of 22 GRB positions are presented and evidence of a VHE signal was found neither in observations of any individual GRBs, nor from stacking data from subsets of GRBs with higher expected VHE flux according to a model-independent ranking scheme. Upper limits for the VHE gamma-ray flux from the GRB positions were derived. For those GRBs with measured redshifts, differential upper limits at the energy threshold after correcting for absorption due to extra-galactic background light are also presented.
Published: 2009

43. Very high energy gamma-ray observations of the galaxy clusters Abell 496 and Abell 85 with H.E.S.S

Author: F. Aharonian, A. G. Akhperjanian, G. Anton, U. Barres de Almeida, A. R. Bazer-Bachi, Y. Becherini, B. Behera, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, I. Braun, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, M. Dalton, M. K. Daniel, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, I. Jung, K. Katarzyński, U. Katz, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, M. Ostrowski, M. Panter, M. Paz Arribas, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, A. Szostek, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, C. van Eldik, G. Vasileiadis, C. Venter, L. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), HESS, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
Subjects: [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Flux, FOS: Physical sciences, Cosmic ray, IACT, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Gamma rays: observations, 01 natural sciences, 7. Clean energy, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], 0103 physical sciences, Cluster (physics), 010303 astronomy & astrophysics, Galaxy cluster, Abell 85, Physics, Accretion (meteorology), 010308 nuclear & particles physics, Astrophysics (astro-ph), Gamma ray, observations [gamma rays], Astronomy and Astrophysics, Galaxy, Space and Planetary Science, clusters: individual: Abell 496 [galaxies], Galaxies: clusters: individual: Abell 496, clusters: individual: Abell 85 [galaxies]
Abstract: Aims: The nearby galaxy clusters Abell 496 and Abell 85 are studied in the very high energy (VHE, E > 100 GeV) band to investigate VHE cosmic rays (CRs) in this class of objects which are the largest gravitationally bound systems in the Universe. Methods: H.E.S.S., an array of four Imaging Atmospheric Cherenkov Telescopes (IACT), is used to observe the targets in the range of VHE gamma rays. Results: No significant gamma-ray signal is found at the respective position of the two clusters with several different source size assumptions for each target. In particular, emission regions corresponding to the high density core, to the extension of the entire X-ray emission in these clusters, and to the very extended region where the accretion shock is expected, are investigated. Upper limits are derived for the gamma-ray flux at energies E>570 GeV for Abell 496 and E>460 GeV for Abell 85. Conclusions: From the non-detection in VHE gamma rays, upper limits on the total energy of hadronic CRs in the clusters are calculated. If the cosmic-ray energy density follows the large scale gas density profile, the limit on the fraction of energy in these non-thermal particles with respect to the total thermal energy of the intra-cluster medium (ICM) is 51% for Abell 496 and only 8% for Abell 85 due to its larger mass and higher gas density. These upper limits are compared with theoretical estimates. They predict about ~10% of the thermal energy of the ICM in non-thermal particles. The observations presented here can constrain these predictions especially for the case of the Abell 85 cluster., 11 pages, 4 figures, accepted for publication in A&A
Published: 2009

44. Simultaneous multiwavelength observations of the second exceptional $\gamma$-ray flare of PKS 2155–304 in July 2006

Author: F. Aharonian, A. G. Akhperjanian, G. Anton, U. Barres de Almeida, A. R. Bazer-Bachi, Y. Becherini, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, L. Costamante, M. Dalton, M. K. Daniel, I. D. Davids, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, D. Göhring, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, C. Jahn, I. Jung, K. Katarzyński, U. Katz, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, W. Kluźniak, T. Kneiske, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, L. A. G. Monard, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, M. Ostrowski, M. Panter, M. Paz Arribas, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, M. Sikora, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, A. Szostek, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, M. Tluczykont, C. van Eldik, G. Vasileiadis, C. Venter, L. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HESS, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Phase (waves), FOS: Physical sciences, Astrophysics, 01 natural sciences, Spectral line, law.invention, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Flux (metallurgy), law, 0103 physical sciences, 010303 astronomy & astrophysics, PKS 2155-304, Physics, 010308 nuclear & particles physics, Gamma ray, observations [gamma rays], Astronomy and Astrophysics, Light curve, galaxies [X-rays], Space and Planetary Science, active [galaxies], BL Lacertae objects: individual: PKS 2155–304 [galaxies], Astrophysics - Cosmology and Nongalactic Astrophysics, Flare, BL Lac object
Abstract: Simultaneous HESS/CHANDRA/optical observations were performed on the BL Lac object PKS 2155-304 in the night of July 29-30 2006, when the source underwent its second major gamma-ray outburst in Summer 2006. This event took place about 44 hours after the July 28 outburst, known for its ultrafast variability. An unprecedented 6 to 8 hours of uninterrupted coverage was achieved, with spectra and light curves measured down to 7 and 2-minute timescales, respectively. The gamma-ray flux reached a maximum of 11x the Crab flux (>400 GeV), with rise/decay timescales of ~1 hour, plus a few smaller-amplitude flares superimposed on the decaying phase. The emission in the X-ray and VHE bands is strongly correlated, both in flux and spectrum, with no evidence of lags. The VHE spectrum shows a curvature that is variable with time and stronger at higher fluxes. The huge VHE variations (22x) are only accompanied by small-amplitude X-ray and optical variations (factor 2 and 15% respectively). The source has shown for the first time in an HBL a large Compton dominance (L_C/L_S ~10) -- rapidly evolving -- and a cubic relation between VHE and X-ray flux variations, during a decaying phase. These results challenge the common scenarios for the TeV-blazar emission., 22 pages, 16 figures, accepted for publication in A&A
Published: 2009

45. Discovery of very high energy $\gamma$-ray emission from Centaurus A with H.E.S.S

Author: F. Aharonian, A. G. Akhperjanian, G. Anton, U. Barres de Almeida, A. R. Bazer-Bachi, Y. Becherini, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, M. Dalton, M. K. Daniel, I. D. Davids, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J.-F. Glicenstein, B. Glück, P. Goret, D. Göhring, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, C. Jahn, I. Jung, K. Katarzyński, U. Katz, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, W. Kluźniak, T. Kneiske, Nu. Komin, K. Kosack, G. Lamanna, I. J. Latham, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, M. Ostrowski, M. Panter, M. Paz Arribas, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, M. Sikora, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, A. Szostek, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, M. Tluczykont, C. van Eldik, G. Vasileiadis, C. Venter, L. Venter, J. P. Vialle, P. Vincent, J. Vink, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HESS, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Radio galaxy, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Centaurus A, FOS: Physical sciences, Flux, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Luminosity, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], individual (Cen A) [galaxies], 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, 010308 nuclear & particles physics, Gamma ray, observations [gamma rays], Astronomy and Astrophysics, Cherenkov Telescope Array, Particle acceleration, Crab Nebula, Space and Planetary Science, active [galaxies], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We report the discovery of faint very high energy (VHE, E>100 GeV) gamma-ray emission from the radio galaxy Centaurus A in observations performed with the H.E.S.S. experiment, an imaging atmospheric Cherenkov telescope array consisting of four telescopes located in Namibia. Centaurus A has been observed for more than 120 h. A signal with a statistical significance of 5.0 sigma is detected from the region including the radio core and the inner kpc jets. The integral flux above an energy threshold of ~250 GeV is measured to be ~0.8 % of the flux of the Crab Nebula (apparent luminosity: L(>250 GeV)~2.6x10^39 erg s^-1, adopting a distance of 3.8 Mpc. The spectrum can be described by a power law with a photon index of 2.7 +/- 0.5_stat +/- 0.2_sys. No significant flux variability is detected in the data set. However, the low flux only allows detection of variability on the timescale of days to flux increments above a factor of ~15-20 (3 sigma and 4 sigma, respectively). The discovery of VHE gamma-ray emission from Centaurus A reveals particle acceleration in the source to >TeV energies and, together with M 87, establishes radio galaxies as a class of VHE emitters., 5 pages, 4 figures, accepted for publication in ApJ Letters
Published: 2009

46. A search for a dark matter annihilation signal towards the Canis Major overdensity with H.E.S.S

Author: F. Aharonian, A. G. Akhperjanian, U. Barres de Almeida, A. R. Bazer-Bachi, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, V. Bochow, V. Borrel, I. Braun, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, S. Carrigan, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, L. Costamante, M. Dalton, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füssling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, I. Jung, K. Katarzyński, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, J. L. Osborne, M. Ostrowski, M. Panter, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, J. L. Skilton, H. Sol, D. Spangler, L. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, C. van Eldik, G. Vasileiadis, C. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), APC - Astrophysique des Hautes Energies (APC - AHE), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), AstroParticule et Cosmologie (APC (UMR_7164)), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), HESS, Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
Subjects: Structure formation, dwarf [galaxies], [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, dark matter, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], WIMP, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Dwarf galaxy, Physics, Annihilation, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Astrophysics (astro-ph), Order (ring theory), observations [gamma rays], Astronomy and Astrophysics, Space and Planetary Science, Neutralino, Halo
Abstract: A search for a dark matter (DM) annihilation signal into $\gamma$-rays toward the direction of the Canis Major (CMa) overdensity is presented. The nature of CMa is still controversial and one scenario represents it as a dwarf galaxy, making it an interesting candidate for DM annihilation searches. A total of 9.6 hours of high quality data were collected with the H.E.S.S. array of Imaging Atmospheric Cherenkov Telescopes (IACTs) and no evidence for a very high energy $\gamma$-ray signal is found. Upper limits on the CMa dwarf galaxy mass of the order of 10$^{9}$ M$_{\odot}$ are derived at the 95% C.L. assuming neutralino masses in the range 500 GeV - 10 TeV and relatively large annihilation cross-sections. Constraints on the velocity-weighted annihilation cross section $$, are calculated for specific WIMP scenarios, using a NFW model for the DM halo profile and taking advantage of numerical simulations of hierarchical structure formation. 95% C.L. exclusion limits of the order of 5 $\times$ 10$^{-24}$ cm$^{3}$ s$^{-1}$ are reached in the 500 GeV - 10 TeV DM particle mass interval, assuming a total halo mass of 3 $\times$ 10$^{8}$ M$_{\odot}$., Comment: Accepted for publication in ApJ
Published: 2009

47. Angiotensin-Induced Growth Related Metabolism Is Activated in Cultured Smooth Muscle Cells From Spontaneously Hypertensive Rats and Wistar-Kyoto Rats

Author: Timothy Scott-Burden, Fritz R. Bühler, Alfred W. A. Hahn, and Thérèse J. Resink
Subjects: Cell type, medicine.medical_specialty, Vascular smooth muscle, Connective tissue, Biology, Ornithine Decarboxylase, Rats, Inbred WKY, Muscle, Smooth, Vascular, Ornithine decarboxylase, Rats, Inbred SHR, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Animals, cardiovascular diseases, Cells, Cultured, Kinase, Angiotensin II, Extracellular Matrix, Rats, Endocrinology, medicine.anatomical_structure, Cell culture, Hypertension, cardiovascular system, Cell Division, Blood vessel
Abstract: Smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate in culture faster than those isolated from sex- and age-matched Wistar- Kyoto (WKY) animals. There was no difference in the kinetics of S6 kinase activation in the two cultures, but later metabolic events associated with proliferation were stimulated earlier in SHR cells than in WKY, eg, activation of ornithine decarboxylase. Both cell types elaborated an extensive extracellular matrix in culture composed of a different blend of connective tissue macromolecules. Matrix material from SHR cells was more stimulatory to growth of WKY cultures than their own matrices. Angiotensin stimulated the growth and synthesis of extra-cellular matrix material in SHR more than in WKY derived vascular smooth muscle cell cul-tures. Am J Hypertens 1991;4:183-188
Published: 1991

48. The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy

Author: Claus W. Heizmann, Paul Erne, Maryse Crabos, T. Yamakado, N. Cerletti, and Fritz R. Bühler
Subjects: Blood Platelets, medicine.medical_specialty, Molecular Sequence Data, Clinical Biochemistry, chemistry.chemical_element, Cardiomegaly, Tropomyosin, macromolecular substances, Biology, Calcium, Left ventricular hypertrophy, Essential hypertension, Biochemistry, Calcium in biology, Muscle hypertrophy, Internal medicine, Calcium-binding protein, medicine, Humans, Amino Acid Sequence, Actin, Myocardium, Calcium-Binding Proteins, General Medicine, medicine.disease, Molecular Weight, Endocrinology, chemistry, Hypertension
Abstract: Intracellular calcium transients play a major role in the control of cellular contraction and act through binding to target proteins and inducing subsequent conformational changes and activation of enzymes. Abnormalities of intracellular calcium handling are involved in the pathophysiology of essential hypertension and cardiac hypertrophy. In this study we report on the isolation, purification and calcium binding of a 33 kDa protein from human platelets and of a 38 kDa protein from cardiac tissue, both of which are identified as tropomyosin. The calcium binding properties of these human tropomyosin isoforms indicate a putative role for these proteins in the fine tuning of the cellular contraction. Elevated tropomyosin level is demonstrated in platelets from untreated essential hypertensive patients with left ventricular hypertrophy (tropomyosin/actin: 45.1 +/- 3.5, n = 12) relative to essential hypertensive patients without cardiac hypertrophy (tropomyosin/actin: 33.8 +/- 2.3). These findings suggest an association between the enhanced expression of tropomyosin in platelets and the development of cardiac hypertrophy which may relate to the cellular calcium overload of this disease.
Published: 1991

49. Release of nitric oxide from human vascular smooth muscle cells

Author: Marcel R. Tschudi, Thomas F. Lüscher, Yasuaki Dohi, Ivo Gut, Fritz R. Bühler, Bernhard Urwyler, and J. Bernhardt
Subjects: Vascular smooth muscle, Biophysics, Biology, Arginine, Nitric Oxide, Biochemistry, Muscle, Smooth, Vascular, Nitric oxide, chemistry.chemical_compound, Smooth muscle, Mole, Animals, Humans, Splanchnic Circulation, Molecular Biology, Cells, Cultured, omega-N-Methylarginine, Endothelium-derived relaxing factor, Cell Biology, Molecular biology, Rats, Perfusion, Endothelial stem cell, Kinetics, chemistry, Cell culture, Luminescent Measurements, Immunology, Liberation
Abstract: It has recently been shown that nitric oxide (NO) or a labile NO-releasing compound is produced in endothelial cells. In the present study we measured the NO-release from human vascular smooth muscle cells in culture. The cells released an average 2.2 x 10(-9) moles nitric oxide per 10(8) cells in ten minutes with a large variation between different cell lines and passages without stimulators. The NO-release was markedly reduced by the inhibitor of NO-formation NG-momomethyl-L-arginine (L-NMMA, 10(-5) M) to 3% of the control levels (p less than 0.02, n = 4), but unaffected by acetylcholine, bradykinin or endothelin -1, -2 or -3. In a microperfusion system the compound released from human vascular smooth muscle cells caused profound relaxation of isolated rat mesenteric resistance arteries. Thus, human vascular smooth muscle cells in culture produce and release biologically active NO from L-arginine.
Published: 1991

50. Stimulation of autocrine platelet- derived growth factor AA-homodimer and transforming growth factor β in vascular smooth muscle cells

Author: Thérèse J. Resink, Alfred W. A. Hahn, Jens Bemhardt, Fritz R. Bühler, and Fabrizia Ferracin
Subjects: medicine.medical_specialty, Platelet-derived growth factor, Macromolecular Substances, medicine.medical_treatment, Blotting, Western, Biophysics, Rats, Inbred WKY, Biochemistry, Muscle, Smooth, Vascular, chemistry.chemical_compound, Species Specificity, Transforming Growth Factor beta, Rats, Inbred SHR, Internal medicine, medicine, Animals, Vasoconstrictor Agents, Growth factor receptor inhibitor, RNA, Messenger, Autocrine signalling, Molecular Biology, Cells, Cultured, Platelet-Derived Growth Factor, biology, Angiotensin II, Endothelins, Growth factor, Cell Biology, Blotting, Northern, Rats, Vascular endothelial growth factor B, Endocrinology, chemistry, Vascular smooth muscle cell differentiation, biology.protein, Platelet-derived growth factor receptor, Transforming growth factor
Abstract: We have investigated the interrelationship between growth factors and vasoconstrictor peptides in terms of their possible paracrine/autocrine regulation of vascular smooth muscle cell differentiation/proliferation. Responses of quiescent cells from spontaneously hypertensive and Wistar-Kyoto rats to stimulation with a selected number of growth factors- and vasoconstrictor peptides were established (induction of mRNA as well as secretion of immunoreactive peptides). A single exposure of quiescent vascular smooth muscle cells to the vasoconstrictor peptides Angiotensin II and Endothelin-1 (10−8 M each) resulted in a prolonged induction of platelet- derived growth factor A-chain and transforming growth factor β transcripts (maximal at 5–6 hrs poststimulatory). The interrelationship between platelet- derived growth factor AA and transforming growth factor β was investigated in experiments using the pure peptides individually for stimulation of mRNA and peptide secretion. Both growth factors enhanced their own and one anothers transcript expression. The results demonstrated that in spontaneously hypertensive rats, an established animal model of hypertension, the steady state balance of this set of growth factors may be disturbed. Defects involved may be attributable to alterations in the secretory machinery and/or amount of autocrine growth factor produced.
Published: 1991

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