2,308 results on '"R, Schmitt"'
Search Results
2. CALDERA: a scientific drilling concept to unravel Connections Among Life, geo-Dynamics and Eruptions in a Rifting Arc caldera, Okataina Volcanic Centre, Aotearoa New Zealand
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C. Massiot, L. Adam, E. S. Boyd, S. C. Cary, D. R. Colman, A. Cox, E. Hughes, G. Kilgour, M. Lelli, D. Liotta, K. G. Lloyd, T. Marr, D. D. McNamara, S. D. Milicich, C. A. Miller, S. Misra, A. R. L. Nichols, S. Pierdominici, S. M. Rooyakkers, D. R. Schmitt, A. Stefansson, J. Stix, M. B. Stott, C. Thomas, P. Villamor, P. Wang, and S. J. Zarrouk
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Geology ,QE1-996.5 - Abstract
Silicic caldera volcanoes present major volcanic and seismic hazards but also host dynamic hydrothermal and groundwater systems and a rich but largely unexplored subsurface biosphere. Many of these volcanoes are hosted in rift settings. The intricate connections and feedbacks among magmatism, rifting, hydrothermal processes, and the biosphere in these complex systems remain poorly understood, necessitating subsurface joint observations that are only enabled by scientific drilling. The CALDERA (Connections Among Life, geo-Dynamics and Eruptions in a Rifting Arc caldera) project workshop funded by the International Continental Scientific Drilling Program (ICDP) gathered multi-disciplinary international experts in January 2023 to advance planning of a scientific drilling project within one of these dynamic, rift-hosted calderas, the Okataina Volcanic Centre (OVC), Aotearoa New Zealand. The OVC's high eruption rate, frequent unrest events and earthquake swarms, location in a densely faulted rapidly extending rift, abundant groundwater–geothermal fluid circulations, and diverse surface hot spring microbiota make it an ideal location for exploring a connected geo-hydro-biosphere via scientific drilling and developing a test bed for novel volcano monitoring approaches. Drilling configurations with at least two boreholes (∼ 200 and ∼ 1000–1500 m deep) were favoured to achieve the multi-disciplinary objectives of the CALDERA project. Decadal monitoring including biosphere activity and composition has the potential to evaluate the response of the hydro-bio system to volcano-tectonic activity. In addition to the OVC caldera-scale datasets already available, site surveys will be conducted to select the best drilling locations. The CALDERA project at the OVC would provide, for the first time, an understanding of volcanic–tectonic–hydrological–biological connections in a caldera–rift system and a baseline for global comparisons with other volcanoes, rifts, and hydrothermal systems. CALDERA would serve as an unprecedented model system to understand how and how quickly the subsurface biosphere responds to geologic activities. Discoveries will improve assessment of volcanic and seismic hazards, guide the sustainable management and/or conservation of groundwater and geothermal resources and microbial ecosystems, and provide a forum for interweaving mātauranga Māori and Western knowledge systems.
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- 2024
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3. Eighteen Exoplanet Host Stars from the NPOI Data Archive
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Ellyn K. Baines, Jeremy Jones, James H. Clark III, Henrique R. Schmitt, and Jordan M. Stone
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Fundamental parameters of stars ,High angular resolution ,Optical interferometry ,Exoplanet astronomy ,Astronomy ,QB1-991 - Abstract
During the course of publishing angular diameters from the Navy Precision Optical Interferometer data archive, we found we had data on 17 confirmed exoplanet host stars and 1 exoplanet candidate (HD 20902/ α Per). Here, we update our previously published stellar radii with more precise Gaia parallaxes when available, and use our radius and effective temperature measurements to fit each star's mass and age using MIST models. The mass changed by more than 10% for 9 of the 18 stars. Combining our updated masses, radii, and temperatures, we present refined planetary masses as well as habitable zone calculations.
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- 2025
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4. Robust Hydropower Planning Balances Energy Generation, Carbon Emissions and Sediment Connectivity in the Mekong River Basin
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M. Tangi, R. Schmitt, R. Almeida, S. Bossi, A. Flecker, F. Sala, and A. Castelletti
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decision‐making ,dam impacts ,uncertainty ,sediment connectivity ,GHG emissions ,strategic planning ,Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
Abstract We present a framework for strategic dam planning under uncertainty, which includes GHG emissions mitigation as a novel objective. We focus on the Mekong River Basin, a fast‐developing region heavily relying on river‐derived ecosystem services. We employ a multi‐objective evolutionary algorithm to identify strategic dam portfolios for different hydropower expansion targets, using process‐related and statistical models to derive indicators of sediment supply disruption and GHG emissions. We introduce a robust optimization approach that explores variations in optimal portfolio compositions for more than 5,000 state‐of‐the‐world configurations, regarding sediment origins and trapping and GHG emissions. Thus, we can rank dam projects' attractiveness based on their frequency of inclusion in optimal portfolios and explore how uncertainty affects these rankings. Our results suggest that developing dams in the upper Mekong would be a more robust option for near‐term development than, for example, the lower Mekong and its tributaries, for both environmental and energy objectives. Our work presents a novel approach to better understand the basin‐scale cumulative impacts of dam development in high‐uncertainty, data‐scarce contexts like the Mekong Basin.
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- 2024
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5. Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
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Kristen M. Stearns-Reider, Michael R. Hicks, Katherine G. Hammond, Joseph C. Reynolds, Alok Maity, Yerbol Z. Kurmangaliyev, Jesse Chin, Adam Z. Stieg, Nicholas A. Geisse, Sophia Hohlbauch, Stefan Kaemmer, Lauren R. Schmitt, Thanh T. Pham, Ken Yamauchi, Bennett G. Novitch, Roy Wollman, Kirk C. Hansen, April D. Pyle, and Rachelle H. Crosbie
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Medicine - Abstract
Abstract We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whether fibrotic ECM scarring affected human skeletal muscle progenitor cell (SMPC) functions that are essential for myoregeneration. SMPCs exhibited robust adhesion, motility, and differentiation on healthy muscle-derived myoscaffolds. All SPMC interactions with fibrotic myoscaffolds from dystrophic muscle were severely blunted including reduced motility rate and migration. Furthermore, SMPCs were unable to remodel laminin dense fibrotic scars within diseased myoscaffolds. Proteomics and structural analysis revealed that excessive collagen deposition alone is not pathological, and can be compensatory, as revealed by overexpression of sarcospan and its associated ECM receptors in dystrophic muscle. Our in vivo data also supported that ECM remodeling is important for SMPC engraftment and that fibrotic scars may represent one barrier to efficient cell therapy.
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- 2023
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6. Effects of a single transdermal administration of flunixin meglumine in early postpartum Holstein Friesian dairy cows: Part 1. Inflammatory and metabolic markers, uterine health, and indicators of pain
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R. Schmitt, L. Pieper, S. Borchardt, J.M. Swinkels, C.-C. Gelfert, and R. Staufenbiel
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inflammation ,transition ,dairy cow ,flunixin meglumine ,metritis ,Dairy processing. Dairy products ,SF250.5-275 ,Dairying ,SF221-250 - Abstract
ABSTRACT: The objectives of this study were to assess the effects of a single transdermal administration of flunixin meglumine (FM) in early postpartum Holstein Friesian dairy cows on serum concentrations of inflammatory and metabolic markers, uterine health, and indicators of pain. The hypothesis was that the anti-inflammatory, antipyretic, and analgetic effects of the pharmaceutic agent would reduce systemic inflammation, resulting in improved metabolic and inflammatory profile, diminished incidence of metritis, and reduced expression of pain. A total of 500 cows (153 primiparous, 347 multiparous) from 3 different commercial dairy farms in the northeast of Germany were included in a randomized controlled clinical trial. Farms were preselected based on high haptoglobin concentrations in their fresh lactating cows. Cows were excluded if they had experienced dystocia, stillbirth, or twin birth, or if they showed any signs of milk fever, retained fetal membranes, or fever (>40°C). The cows were treated once with either FM (3.33 mg/kg) or a placebo as control (CON) through transdermal administration between 24 to 36 h postpartum (d 2). General health examinations were performed (daily from d 2–8 and additionally on d 15 postpartum), vaginal discharge was assessed using the Metricheck device (d 8 and 15 postpartum) and serum samples were analyzed for inflammatory and metabolic markers (d 2, 4, and 6 postpartum). Effects of treatment, parity, sampling day, and their interactions were evaluated using mixed effects models. Primiparous cows treated with FM showed lower serum haptoglobin concentrations (0.90 ± 0.08 vs. 1.17 ± 0.07 g/L; ± standard error of the mean) and higher serum albumin concentrations (35.5 ± 0.31 vs. 34.8 ± 0.31 g/L) on d 6 postpartum. They also had a lower risk for purulent vaginal discharge with or without a fever compared with CON cows on d 15 postpartum (odds ratio for CON vs. FM: 1.63, 95% CI: 1.26–2.00), and body temperature was lower throughout the first 15 d in milk (39.1 ± 0.11 vs. 39.2 ± 0.11°C). Multiparous cows treated with FM had lower serum β-hydroxybutyrate concentrations on d 4 postpartum (0.71 ± 0.05 vs. 0.78 ± 0.05 mmol/L) and d 6 postpartum (0.74 ± 0.05 vs. 0.80 ± 0.05 mmol/L). Regardless of parity, FM-treated cows were significantly less likely to abduct their tail from their body (14.3 vs. 23.6%) and show an arched back (27.9 vs. 39.7%) on the day after treatment compared with CON cows. It can be concluded that FM treatment slightly reduced inflammation and diminished the risk for metritis in primiparous cows, improved metabolic profile in multiparous cows, and reduced expressions of pain in all cows.
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- 2023
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7. Effects of a single transdermal administration of flunixin meglumine in early postpartum Holstein Friesian dairy cows: Part 2. Milk yield, culling risk, and reproductive performance
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R. Schmitt, L. Pieper, S. Borchardt, J.M. Swinkels, C.-C. Gelfert, and R. Staufenbiel
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transition dairy cow ,flunixin meglumine ,milk yield ,reproductive performance ,Dairy processing. Dairy products ,SF250.5-275 ,Dairying ,SF221-250 - Abstract
ABSTRACT: This study was conducted to assess the effects of a single transdermal administration of flunixin meglumine (FM) in early postpartum Holstein Friesian dairy cows on milk yield, culling risk, and reproductive performance. We hypothesized that FM treatment would reduce systemic inflammation, leading to higher milk yield, reduced culling risk, and better reproductive performance in the subsequent lactation. Holstein Friesian dairy cows [n = 500, 153 primiparous (PRIM), 347 multiparous (MULT)] from 3 farms in northeast Germany were enrolled in a prospective, randomized controlled clinical trial. Farms at risk for cows with excessive postpartum inflammation were identified in a preliminary trial by measuring serum haptoglobin concentrations in their fresh lactating cows. Only cows that had a eutocic birth and delivered a singleton calf alive, with no signs of milk fever or retained fetal membranes and rectal temperature ≤40°C at first clinical examination, were included within 24 to 36 h postpartum. Treatment included a single transdermal administration of either FM (3.33 mg/kg) or a placebo as control (CON). Milk production, milk solids, urea, and somatic cell count were recorded monthly for 8 mo after calving. Culling risk, first-service conception risk, and days open were retrieved from the farms' herd management software. Separate models for PRIM and MULT cows were built for most parameters because of significant effects of parity and parity × treatment interaction. Energy-corrected milk yield from 8 monthly Dairy Herd Improvement-equivalent tests was slightly greater in PRIM cows treated with FM (29.51 and 30.73 ± 1.35 kg, CON vs. FM), whereas it was reduced in treated MULT cows (38.23 and 37.47 ± 1.17 kg, CON vs. FM) compared with CON. Milk fat and protein yields were greater in FM-treated PRIM cows and lower in treated MULT cows compared with CON. Milk urea and somatic cell count were not affected by treatment. No differences in culling risk, first-service conception risk, or days open were observed. We conclude that a single transdermal administration of FM in early postpartum dairy cows on farms at risk for excessive postpartum inflammation slightly increased milk, milk fat, and milk protein yields in PRIM cows and decreased these variables in MULT cows. Neither culling risk nor fertility was affected by treatment in this study.
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- 2023
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8. Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
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Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, and Rachelle H. Crosbie
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Duchenne muscular dystrophy ,Dystrophin ,Dystroglycan ,Extracellular matrix ,Sarcospan ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during repeated muscle contractions. One integral component of the DGC is the transmembrane protein, sarcospan (SSPN). Overexpression of SSPN in the skeletal muscle of mdx mice (murine model of DMD) restores muscle fiber attachment to the ECM in part through an associated increase in utrophin and integrin adhesion complexes at the cell membrane, protecting the muscle from contraction-induced injury. In this study, we utilized transcriptomic and ECM protein-optimized proteomics data sets from wild-type, mdx, and mdx transgenic (mdx TG) skeletal muscle tissues to identify pathways and proteins driving the compensatory action of SSPN overexpression. Methods The tibialis anterior and quadriceps muscles were isolated from wild-type, mdx, and mdx TG mice and subjected to bulk RNA-Seq and global proteomics analysis using methods to enhance capture of ECM proteins. Data sets were further analyzed through the ingenuity pathway analysis (QIAGEN) and integrative gene set enrichment to identify candidate networks, signaling pathways, and upstream regulators. Results Through our multi-omics approach, we identified 3 classes of differentially expressed genes and proteins in mdx TG muscle, including those that were (1) unrestored (significantly different from wild type, but not from mdx), (2) restored (significantly different from mdx, but not from wild type), and (3) compensatory (significantly different from both wild type and mdx). We identified signaling pathways that may contribute to the rescue phenotype, most notably cytoskeleton and ECM organization pathways. ECM-optimized proteomics revealed an increased abundance of collagens II, V, and XI, along with β-spectrin in mdx TG samples. Using ingenuity pathway analysis, we identified upstream regulators that are computationally predicted to drive compensatory changes, revealing a possible mechanism of SSPN rescue through a rewiring of cell-ECM bidirectional communication. We found that SSPN overexpression results in upregulation of key signaling molecules associated with regulation of cytoskeleton organization and mechanotransduction, including Yap1, Sox9, Rho, RAC, and Wnt. Conclusions Our findings indicate that SSPN overexpression rescues dystrophin deficiency partially through mechanotransduction signaling cascades mediated through components of the ECM and the cortical cytoskeleton.
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- 2023
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9. Taf2 mediates DNA binding of Taf14
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Brianna J. Klein, Jordan T. Feigerle, Jibo Zhang, Christopher C. Ebmeier, Lixin Fan, Rohit K. Singh, Wesley W. Wang, Lauren R. Schmitt, Thomas Lee, Kirk C. Hansen, Wenshe R. Liu, Yun-Xing Wang, Brian D. Strahl, P. Anthony Weil, and Tatiana G. Kutateladze
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Science - Abstract
Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for the engagement with the nucleosome and their association with DNA is essential for transcriptional regulation.
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- 2022
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10. Classifying Intermediate-redshift Galaxies in SDSS: Alternative Diagnostic Diagrams
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Léa M. Feuillet, Marcio Meléndez, Steve Kraemer, Henrique R. Schmitt, Travis C. Fischer, and James N. Reeves
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Active galactic nuclei ,Classification systems ,Starburst galaxies ,Astrophysics ,QB460-466 - Abstract
We select a sample of 1437 active galactic nuclei (AGN) from the catalog of the Sloan Digital Sky Survey galaxy properties from the Portsmouth group by detection of the high-ionization [Ne v ] 3426 Å emission line. We compare the fluxes of [Ne III ] 3869 Å, [O III ] 5007 Å, [O II ] 3726, 3728 Å, and [O i ] 6300 Å to that of [Ne v]. All four lines show a strong linear correlation with [Ne v], although lines from ions with lower ionization potentials have a lower correlation coefficient. We investigate the use of two forbidden line ratio diagnostic diagrams that do not rely on H α in order to classify high-redshift galaxies. These use the [Ne III ]/[O II ] line ratio plotted against [O III ]/[O i ] and [O III ]/[O II ], respectively. We use photoionization modeling to characterize the behavior of the narrow-line region in AGN and star-forming regions and test the validity of our diagnostic diagrams. We also use a luminosity cutoff of log L _[O _III _] [erg s ^−1 ] = 42, which lowers the contamination of the AGN region by star-forming galaxies down to 10% but does not remove green pea and purple grape galaxies from the AGN region. We also investigate the OHNO diagram, which uses [Ne III ]/[O II ] plotted against [O III ]/H β . Using our new diagnostic diagrams, we are able to reliably classify AGN up to a redshift of z ≤ 1.06 and add more than 822 new AGN to the [Ne v]-selected AGN sample.
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- 2024
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11. Star Formation Rates in [Ne V] 3426 Å Selected Active Galactic Nuclei: Evidence for a Decrease along the Main Sequence?
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Léa M. Feuillet, Marcio Meléndez, Steve Kraemer, Henrique R. Schmitt, Travis C. Fischer, and James N. Reeves
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Active galaxies ,Starburst galaxies ,Star formation ,Astrophysics ,QB460-466 - Abstract
Studying the behavior along the galaxy main sequence is key in furthering our understanding of the possible connection between active galactic nucleus (AGN) activity and star formation. We select a sample of 1215 AGN from the catalog of Sloan Digital Sky Survey galaxy properties from the Portsmouth group by detection of the high-ionization [Ne v ] 3426 Å emission line. Our sample extends from 10 ^40 to 10 ^42.5 erg s ^−1 in [Ne v ] luminosity in a redshift range z = 0.17 to 0.57. We compare the specific star formation rates (sSFRs; SFR scaled by galaxy mass) obtained from the corrected [O ii ] and H α luminosities, and the spectral energy distribution (SED)–determined values from Portsmouth. We find that the emission-line-based sSFR values are unreliable for the [Ne v ] sample due to the AGN contribution, and proceed with the SED sSFRs for our study of the main sequence. We find evidence for a decrease in sSFR along the main sequence in the [Ne v ] sample, which is consistent with results from the hard X-ray Burst Alert Telescope AGN sample, which extends to lower redshifts than our [Ne v ] sample. Although we do not find evidence that the concurrent AGN activity is suppressing star formation, our results are consistent with a lower gas fraction in the host galaxies of the AGN as compared to that of the star-forming galaxies. If the evacuation of gas, and therefore suppression of star formation, is due to AGN activity, it must have occurred in a previous epoch.
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- 2024
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12. Resolving a Candidate Dual Active Galactic Nucleus with ∼100 pc Separation in MCG-03-34-64
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Anna Trindade Falcão, T. J. Turner, S. B. Kraemer, J. Reeves, V. Braito, H. R. Schmitt, and L. Feuillet
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AGN host galaxies ,Seyfert galaxies ,High energy astrophysics ,Astrophysics ,QB460-466 - Abstract
We report the serendipitous multiwavelength discovery of a candidate dual black hole system with a separation of ∼100 pc, in the gas-rich luminous infrared galaxy MCG-03-34-64 ( z = 0.016). Hubble Space Telescope/Advanced Camera for Surveys observations show three distinct optical centroids in the [O iii ] narrow-band and F814W images. Subsequent analysis of Chandra/ACIS data shows two spatially resolved peaks of equal intensity in the neutral Fe K α (6.2–6.6 keV) band, while high-resolution radio continuum observations with the Very Large Array at 8.46 GHz (3.6 cm band) show two spatially coincident radio peaks. Fast shocks as the ionizing source seem unlikely, given the energies required for the production of Fe K α . If confirmed, the separation of ∼100 pc would represent the closest dual active galactic nuclei reported to date with spatially resolved, multiwavelength observations.
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- 2024
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13. Determining the Extents, Geometries, and Kinematics of Narrow-line Region Outflows in Nearby Seyfert Galaxies
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Garrett E. Polack, Mitchell Revalski, D. Michael Crenshaw, Travis C. Fischer, Henrique R. Schmitt, Steven B. Kraemer, Beena Meena, and Marc Rafelski
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Seyfert galaxies ,AGN host galaxies ,Galaxy kinematics ,Active galaxies ,Active galactic nuclei ,Astrophysics ,QB460-466 - Abstract
Outflowing gas from supermassive black holes in the centers of active galaxies has been postulated as a major contributor to galactic evolution. To explore the interaction between narrow-line region (NLR) outflows and their host galaxies, we use Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph (STIS) spectra and Wide Field Camera 3 (WFC3) images of 15 nearby ( z < 0.02) active galactic nuclei (AGN) to determine the extents and geometries of their NLRs. We combine new HST WFC3 continuum and [O iii ] λ 5007 images of 11 AGN with four archival AGN to match existing spectra from HST STIS. For the six AGN with suitable long-slit coverage of their NLRs, we use isophotal fitting of ground-based images, continuum-subtracted [O iii ] images, and the STIS spectra, to resolve, measure, and de-project the gas kinematics to the plane of the host galaxy disk and distinguish NLR outflows from galaxy rotation and/or kinematically disturbed gas. We find an average [O iii ] extent of ∼680 pc with a correlation between gas extent and [O iii ] luminosity of R _[O III] ∝ ${L}_{[{\rm{O}}\,\mathrm{III}]}^{0.39}$ . The measured extents depend strongly on the depth of the [O iii ] images, highlighting the importance of adopting uniform thresholds when analyzing scaling relationships. The outflows reach from 39% to 88% of the full NLR extents, and we find that all six of the AGN with STIS coverage of their entire NLRs show strong kinematic evidence for outflows, despite previous uncertainty for these AGN. This suggests that NLR outflows are ubiquitous in moderate-luminosity AGN and that standard criteria for kinematic modeling are essential for identifying outflows.
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- 2024
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14. A Comparison of Devices for Race Day Characterization of North American Turfgrass Thoroughbred Racing Surfaces
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Peter R. Schmitt, Wayne Sanderson, John (Trey) Rogers, Tyler J. Barzee, and Michael (Mick) Peterson
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equine ,jockey ,safety ,turfgrass ,racing ,portable tools ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Both pre-race meet and daily turf surface condition measurements are required by regulations adopted as part of the Horseracing Integrity and Safety Act (HISA). The Orono Biomechanical Surface Tester (OBST) is the primary device used for characterizing a racing surface and is used for the pre-meet inspections. Tools that are better suited for the daily testing of turf surfaces are also needed to meet the new federal regulations. The purpose of this study was to compare five simple tools commonly used in turf applications to the OBST. Data were collected with each of the six devices at plots chosen to approximate the current and potential compositions of North American turf racetracks. Correlations and linear regression models were then established between the simple tool measurements and the parameters measured by the OBST. The moisture probe was found to be the primary device for race day characterization due to its strong correlation to OBST measurements. The Longchamp Penetrometer is also prioritized for daily measurements due to its established correlation to horse performance and injuries. The Clegg Impact Hammer provides further improvement of the linear regression model. The Turf Shear Tester and GoingStick® were not found to correlate well to the biomechanically based device.
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- 2023
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15. Unicompartmental knee arthroplasty and revision total knee arthroplasty have a lower risk of venous thromboembolism disease at 30 days than primary total knee arthroplasty
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Andrew M. Schneider, Daniel R. Schmitt, and Nicholas M. Brown
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Total knee arthroplasty ,Unicompartmental knee arthroplasty ,Venous thromboembolic disease ,Revision knee arthroplasty ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Background While multiple studies have demonstrated a lower venous thromboembolism disease (VTED) risk for unicompartmental knee arthroplasty (UKA) compared to primary total knee arthroplasty (TKA), recent reports have shown that revision TKA also had a lower VTED risk compared to primary TKA, an unexpected finding because of its theoretical increased risk. Given the paucity of up-to-date comparative studies, our goal was to perform a high-powered VTED risk comparison study of UKA and revision TKA to primary TKA using recent data. Methods The National Surgical Quality Improvement Program (NSQIP) database was queried between 2011 and 2018, and we identified 213,234 patients for inclusion: 191,810 primary TKA, 9294 UKA, and 12,130 revision TKA. Demographics, medical comorbidities, and possible VTE risk factors were collected. Thirty-day outcomes, including deep vein thrombosis (DVT), pulmonary embolism (PE), and all-cause VTED were compared between knee arthroplasty types. Results On multivariate analysis, UKA was significantly associated with lower rates of DVT [OR 0.44 (0.31–0.61); P
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- 2020
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16. Borehole Seismic Observations From the Chicxulub Impact Drilling: Implications for Seismic Reflectivity and Impact Damage
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C. G. Nixon, D. R. Schmitt, R. Kofman, J. Lofi, S. P. S. Gulick, S. Saustrup, G. L. Christeson, and D. A. Kring
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vertical seismic profile ,grady kipp damage parameters ,shocked rock physics ,chicxulub impact crater ,in situ seismic reflectivity ,borehole logging ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
Abstract We conducted a vertical seismic profile (VSP) in the borehole of International Ocean Discovery Program/International Continental Scientific Drilling Program Expedition 364 Site M0077 to better understand the nature of the seismic reflectivity and the in situ seismic properties associated with the Chicxulub impact structure peak ring. Extraction of the up‐going wavefield from the VSP shows that a strong seismic reflection event imaged in seismic reflection data results from discontinuities in the elastic impedance Z (the product of density and wave speed) at the top and bottom of a zone of hydrothermally altered melt‐bearing polymict breccia (suevite) that are characterized by anomalously low Z. Below this strong carbonate/suevite reflection event, the upgoing seismic wavefield is chaotic, indicating high levels of scattering from the suevites and underlying melt rocks and shocked granitoids of the peak ring, in contrast to the clear coherent reflections throughout the overlying Cenozoic sediments. We extract shear wave speeds, which, together with those provided from the complementary sonic log and densities from core scanning, allowed determination of VP/VS and Poisson's ratio v. These values are anomalously high relative to comparable terrestrial lithologies. We also calculate a variety of damage parameters for the disrupted peak ring granitoids. These values may assist in linking seismic observations to shock levels that are necessary to calibrate current impact models and may also be useful in assessing levels of fracturing within major fault zones.
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- 2022
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17. The Visual Survey Group: A Decade of Hunting Exoplanets and Unusual Stellar Events with Space-based Telescopes
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Martti H Kristiansen, Saul A Rappaport, Andrew M Vanderburg, Thomas L Jacobs, Hans Martin Schwengeler, Robert Gagliano, Ivan A. Terentev, Daryll M. LaCourse, Mark R. Omohundro, Allan R. Schmitt, Brian P Powell, and Veselin B Kostov
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Astronomy - Abstract
This article presents the history of the Visual Survey Group (VSG)—a Professional-Amateur (Pro-Am) collaboration within the field of astronomy working on data from several space missions (Kepler, K2 and Transiting Exoplanet Survey Satellite). This paper covers the formation of the VSG, its survey-methods including the most common tools used and its discoveries made over the past decade. So far, the group has visually surveyed nearly 10 million light curves and authored 69 peer-reviewed papers which mainly focus on exoplanets and discoveries involving multistellar systems. The preferred manual search-method carried out by the VSG has revealed its strength by detecting numerous objects which were overlooked or discarded by automated search programs, uncovering some of the most rare stars in our galaxy, and leading to several serendipitous discoveries of unprecedented astrophysical phenomena. The main purpose of the VSG is to assist in the exploration of our local universe, and we therefore advocate continued crowd-sourced examination of time-domain data sets, and invite other research teams to reach out in order to establish collaborating projects.
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- 2022
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18. Simultaneous Six-way Observations from the Navy Precision Optical Interferometer
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Ellyn K. Baines, Solvay Blomquist, James H. Clark III, Jim Gorney, Erin Maier, Jason Sanborn, Henrique R. Schmitt, Jordan M. Stone, Gerard T. van Belle, and Kaspar von Braun
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Fundamental parameters of stars ,High angular resolution ,Optical interferometry ,Astronomy ,QB1-991 - Abstract
We measured the angular diameters of six stars using the six-element observing mode of the Navy Precision Optical Interferometer (NPOI) for the first time since the early 2000s. Four of the diameters ranged from 1.2 to 1.9 mas, while the two others were much smaller at approximately 0.5 mas to 0.7 mas, which are the two smallest angular diameters measured to date with the NPOI. There is a larger spread in the measurements than data obtained with three-, four-, or five-element modes, which can be attributed in part to the flux imbalance due to the combination of more than two siderostats in a single spectrograph, and also to crosstalk between multiple baselines related to nonlinearities in the fast-delay-line dither strokes. We plan to address this in the future by using the VISION beam combiner.
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- 2023
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19. Investigating the Narrow-line Region Dynamics in Nearby Active Galaxies
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Beena Meena, D. Michael Crenshaw, Henrique R. Schmitt, Mitchell Revalski, Zo Chapman, Travis C. Fischer, Steven B. Kraemer, Justin H. Robinson, Julia Falcone, and Garrett E. Polack
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Active galactic nuclei ,AGN host galaxies ,Seyfert galaxies ,Emission line galaxies ,Galaxy winds ,Galaxy kinematics ,Astrophysics ,QB460-466 - Abstract
We present dynamical models of the narrow-line region (NLR) outflows in the nearby Seyfert galaxies Mrk 3, Mrk 78, NGC 1068, and NGC 4151 using observations from the Hubble Space Telescope and Apache Point Observatory. We employ long-slit spectroscopy to map the spatially resolved outflow and rotational velocities of the ionized gas. We also perform surface brightness decompositions of host galaxy images to constrain the enclosed stellar mass distributions as functions of distance from the supermassive black holes (SMBHs). Assuming that the NLR gas is accelerated by active galactic nuclei (AGN) radiation pressure, and subsequently decelerated by the host galaxy and SMBH gravitational potentials, we derive outflow velocity profiles where the gas is launched in situ at multiple distances from the SMBH. We find a strong correlation between the turnover (from acceleration to deceleration) radii from our models, with the turnovers seen in the observed velocities and spatially resolved mass outflow rates for the AGN with bolometric luminosities > 10 ^44 erg s ^−1 . This consistency indicates that radiation pressure is the dominant driving mechanism behind the NLR outflows in these moderate-luminosity AGNs, with a force multiplier ∼500 yielding the best agreement between the modeled and observed turnover radii. However, in Meena et al. we found that this trend may not hold at lower luminosities, where our modeled turnover distance for NGC 4051 is much smaller than in the observed kinematics. This result may indicate that either additional force(s) are responsible for accelerating the NLR outflows in low-luminosity AGNs, or higher spatial resolution observations are required to quantify their turnover radii.
- Published
- 2023
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- View/download PDF
20. 33 New Stellar Angular Diameters from the NPOI, and Nearly 180 NPOI Diameters as an Ensemble
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Ellyn K. Baines, James H. Clark III, Henrique R. Schmitt, Jordan M. Stone, and Kaspar von Braun
- Subjects
Fundamental parameters of stars ,High angular resolution ,Optical interferometry ,Astronomy ,QB1-991 - Abstract
We present new angular diameter measurements for 33 stars from the Navy Precision Optical Interferometer, reaching uncertainties on the limb-darkened diameter of 2% or less for 21 targets. We also determined the physical radius, bolometric flux, luminosity, and effective temperature for each star. Our sample is a mix of giant, subgiant, and dwarf stars, and span spectral classes from mid-A to to mid-K. We combined these 33 stars with samples from previous publications to analyze how the NPOI diameters compare to those obtained using other means, namely ( V − K ) color, the JMMC Stellar Diameters Catalog, and Gaia predictions.
- Published
- 2023
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21. The compact triply eclipsing triple star TIC 209409435 discovered with TESS
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T Borkovits, S A Rappaport, T G Tan, R Gagliano, T Jacobs, X Huang, T Mitnyan, F-J Hambsch, T Kaye, P F L Maxted, A Pál, and A R Schmitt
- Published
- 2020
- Full Text
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22. Quantifying Feedback from Narrow Line Region Outflows in Nearby Active Galaxies. IV. The Effects of Different Density Estimates on the Ionized Gas Masses and Outflow Rates
- Author
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Mitchell Revalski, Michael Crenshaw, Marc Rafelski, Steven B Kraemer, Garrett E Polack, Anna Trindade Falcão, Travis C Fischer, Beena Meena, Francisco Martinez, Henrique R Schmitt, Nicholas R Collins, and Julia Falcone
- Subjects
Astrophysics - Abstract
Active galactic nuclei (AGN) can launch outflows of ionized gas that may influence galaxy evolution, and quantifying their full impact requires spatially resolved measurements of the gas masses, velocities, and radial extents. We previously reported these quantities for the ionized narrow-line region outflows in six low-redshift AGN, where the gas velocities and extents were determined from Hubble Space Telescope long-slit spectroscopy. However, calculating the gas masses required multicomponent photoionization models to account for radial variations in the gas densities, which span ∼6 orders of magnitude. To simplify this method for larger samples with less spectral coverage, we compare these gas masses with those calculated from techniques in the literature. First, we use a recombination equation with three different estimates for the radial density profiles. These include constant densities, those derived from [S ii], and power-law profiles based on constant values of the ionization parameter (U). Second, we use single-component photoionization models with power-law density profiles based on constant U, and allow U to vary with radius based on the [O iii]/Hβ ratios. We find that assuming a constant density of nH = 10(^2) cm(^−3) overestimates the gas masses for all six outflows, particularly at small radii where the outflow rates peak. The use of [S ii] marginally matches the total gas masses, but also overestimates at small radii. Overall, single-component photoionization models where U varies with radius are able to best match the gas mass and outflow rate profiles when there are insufficient emission lines to construct detailed models.
- Published
- 2022
- Full Text
- View/download PDF
23. Evaluation of the geothermal potential of the western Snake River Plain based on a deep corehole on the Mountain Home AFB near Mountain Home, Idaho
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Thomas E. Lachmar, Thomas G. Freeman, James A. Kessler, Joseph F. Batir, James P. Evans, Dennis L. Nielson, John W. Shervais, Xiwei Chen, Douglas R. Schmitt, and David D. Blackwell
- Subjects
Temperature log ,Heat flow ,Geothermometers ,Basalt ,UCS experiments ,Renewable energy sources ,TJ807-830 ,Geology ,QE1-996.5 - Abstract
Abstract A geothermal exploration corehole was drilled to a total depth of 1821.5 m on the Mountain Home Air Force Base near Mountain Home, Idaho. The corehole was used to collect an unusually large amount of data, including uniaxial compressive stress (UCS) experiments on core samples, to evaluate the geothermal potential of the western Snake River Plain. In addition, unlike many exploration holes in this region, a fluid entry was encountered at 1745.3 m and flowed artesian to the surface. A maximum temperature of 149.4 °C was calculated for the entry. A temperature log run on the corehole from 3 to 1675 m is nearly linear with little variation. The average geothermal gradient is 73 °C/km, and the average heat flow between 200 and 1500 m is 102 ± 15 mW/m2. Chemical analyses of a sample from the fluid entry suggest that a significant proportion of the water is not meteoric. Five geothermometers show equilibrium temperature in the range of 133–157 °C. Furthermore, based on the unconfined UCS experiments on basalt core samples, a brittle unit was found to comprise the fractured reservoir that the geothermal water flows from, while an overlying ductile unit acts as a hydrothermal caprock. This implies that the reservoir/caprock pair may be a target for future exploration wells drilled to delineate the extent of the potential resource and the boundaries of the connected fracture network.
- Published
- 2019
- Full Text
- View/download PDF
24. Frictional Stabilities on Induced Earthquake Fault Planes at Fox Creek, Alberta: A Pore Fluid Pressure Dilemma
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L. W. Shen, D. R. Schmitt, and R. Schultz
- Subjects
fault stability ,hydraulic fracturing ,geomechanical modeling ,mechanics of earthquake faulting ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract Earthquakes induced during hydraulic fracturing operations have occurred in a number of locales. However, in situ studies aimed to discern the triggering mechanism remain exclusively statistical in their nature. Here we calculate the fault slip tendencies of 11 hydraulic fracturing induced earthquakes in a historically aseismic area using a recently constructed quantitative model for the in‐situ stresses. It is shown that the ambient pore pressures of the nearby Duvernay unconventional reservoirs can provide enough ΔPf triggering fault movement. The local fluid pressures acting on the fault could readily be increased above the critical value if hydraulic connection exists between the fault and a propagating hydraulic fracture. The critical pressures necessary to induce slip are estimated using a probabilistic model that incorporates uncertainties of stress and fault's mechanical properties. These critical pressures are greater than the expected hydrostatic pressure but less the pore pressures of nearby unconventional reservoirs.
- Published
- 2019
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- View/download PDF
25. Prevention Techniques Have Had Minimal Impact on the Population Rate of Prosthetic Joint Infection for Primary Total Hip and Knee Arthroplasty: A National Database Study
- Author
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Michael P. Murphy, Ashley E. MacConnell, Cameron J. Killen, Daniel R. Schmitt, Karen Wu, William J. Hopkinson, and Nicholas M. Brown
- Subjects
Orthopedics and Sports Medicine - Published
- 2023
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- View/download PDF
26. Mass outflow of the X-ray emission line gas in NGC 4151
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S B Kraemer, T J Turner, J D Couto, D M Crenshaw, H R Schmitt, M Revalski, and T C Fischer
- Published
- 2020
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- View/download PDF
27. TIC 219006972: a compact, coplanar quadruple star system consisting of two eclipsing binaries with an outer period of 168 d
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Veselin B Kostov, Tamás Borkovits, Saul A Rappaport, Brian P Powell, András Pál, Thomas L Jacobs, Robert Gagliano, Martti H Kristiansen, Daryll M LaCourse, Maxwell Moe, Mark Omohundro, Allan R Schmitt, Hans M Schwengeler, Ivan A Terentev, and Andrew Vanderburg
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Solar and Stellar Astrophysics (astro-ph.SR) - Abstract
We present the discovery of a new highly compact quadruple star system, TIC 219006972, consisting of two eclipsing binary stars with orbital periods of 8.3 days and 13.7 days, and an outer orbital period of only 168 days. This period is a full factor of 2 shorter than the quadruple with the shortest outer period reported previously, VW LMi, where the two binary components orbit each other every 355 days. The target was observed by TESS in Full-Frame Images in sectors 14-16, 21-23, 41, 48 and 49, and produced two sets of primary and secondary eclipses. These show strongly non-linear eclipse timing variations (ETVs) with an amplitude of $\sim$0.1 days, where the ETVs of the primary and secondary eclipses, and of the two binaries are all largely positively correlated. This highlights the strong dynamical interactions between the two binaries and confirms the compact quadruple configuration of TIC 219006972. The two eclipsing binaries are nearly circular whereas the quadruple system has an outer eccentricity of about 0.25. The entire system is nearly edge-on, with a mutual orbital inclination between the two eclipsing binary star systems of about 1 degree., 16 pages, 13 figures, 4 tables, MNRAS accepted
- Published
- 2023
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28. Sports-related injuries of the thumb and fingers
- Author
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N. Hesse, P. Reidler, and R. Schmitt
- Published
- 2023
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- View/download PDF
29. A nuclear ionized gas outflow in the Seyfert 2 galaxy UGC 2024
- Author
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Dania Muñoz-Vergara, Neil M Nagar, Venkatessh Ramakrishnan, Carolina Finlez, Thaisa Storchi-Bergmann, Roy Slater, Veronica Firpo, Pedro K Humire, Pamela Soto-Pinto, Steven B Kraemer, Davide Lena, Andrew Robinson, Rogemar A Riffel, D Michael Crenshaw, Martin S Elvis, T C Fischer, Allan Schnorr-Müller, and Henrique R Schmitt
- Published
- 2019
- Full Text
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30. Growable realizations: a powerful approach to the Buratti-Horak-Rosa Conjecture.
- Author
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M. A. Ollis, Anita Pasotti, Marco Antonio Pellegrini, and John R. Schmitt
- Published
- 2022
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31. Drilling-induced and logging-related features illustrated from IODP–ICDP Expedition 364 downhole logs and borehole imaging tools
- Author
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J. Lofi, D. Smith, C. Delahunty, E. Le Ber, L. Brun, G. Henry, J. Paris, S. Tikoo, W. Zylberman, P. A. Pezard, B. Célérier, D. R. Schmitt, C. Nixon, and Expedition 364 Science Party
- Subjects
Geology ,QE1-996.5 - Abstract
Expedition 364 was a joint IODP and ICDP mission-specific platform (MSP) expedition to explore the Chicxulub impact crater buried below the surface of the Yucatán continental shelf seafloor. In April and May 2016, this expedition drilled a single borehole at Site M0077 into the crater's peak ring. Excellent quality cores were recovered from ∼ 505 to ∼ 1335 m below seafloor (m b.s.f.), and high-resolution open hole logs were acquired between the surface and total drill depth. Downhole logs are used to image the borehole wall, measure the physical properties of rocks that surround the borehole, and assess borehole quality during drilling and coring operations. When making geological interpretations of downhole logs, it is essential to be able to distinguish between features that are geological and those that are operation-related. During Expedition 364 some drilling-induced and logging-related features were observed and include the following: effects caused by the presence of casing and metal debris in the hole, logging-tool eccentering, drilling-induced corkscrew shape of the hole, possible re-magnetization of low-coercivity grains within sedimentary rocks, markings on the borehole wall, and drilling-induced changes in the borehole diameter and trajectory.
- Published
- 2018
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- View/download PDF
32. The Alpine Fault Hangingwall Viewed From Within: Structural Analysis of Ultrasonic Image Logs in the DFDP‐2B Borehole, New Zealand
- Author
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Cécile Massiot, Bernard Célérier, Mai‐Linh Doan, Tim A. Little, John Townend, David D. McNamara, Jack Williams, Douglas R. Schmitt, Virginia G. Toy, Rupert Sutherland, Lucie Janku‐Capova, Phaedra Upton, and Philippe A. Pezard
- Subjects
Alpine Fault ,ultrasonic image log ,foliation ,fractures ,anisotropy ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
Abstract Ultrasonic image logs acquired in the DFDP‐2B borehole yield the first continuous, subsurface description of the transition from schist to mylonite in the hangingwall of the Alpine Fault, New Zealand, to a depth of 818 m below surface. Three feature sets are delineated. One set, comprising foliation and foliation‐parallel veins and fractures, has a constant orientation. The average dip direction of 145° is subparallel to the dip direction of the Alpine Fault, and the average dip magnitude of 60° is similar to nearby outcrop observations of foliation in the Alpine mylonites that occur immediately above the Alpine Fault. We suggest that this foliation orientation is similar to the Alpine Fault plane at ∼1 km depth in the Whataroa valley. The other two auxiliary feature sets are interpreted as joints based on their morphology and orientation. Subvertical joints with NW‐SE (137°) strike occurring dominantly above ∼500 m are interpreted as being formed during the exhumation and unloading of the Alpine Fault's hangingwall. Gently dipping joints, predominantly observed below ∼500 m, are interpreted as inherited hydrofractures exhumed from their depth of formation. These three fracture sets, combined with subsidiary brecciated fault zones, define the fluid pathways and anisotropic permeability directions. In addition, high topographic relief, which perturbs the stress tensor, likely enhances the slip potential and thus permeability of subvertical fractures below the ridges, and of gently dipping fractures below the valleys. Thus, DFDP‐2B borehole observations support the inference of a large zone of enhanced permeability in the hangingwall of the Alpine Fault.
- Published
- 2018
- Full Text
- View/download PDF
33. Quantifying Feedback from Narrow Line Region Outflows in Nearby Active Galaxies. III. Results for the Seyfert 2 Galaxies Markarian 3, Markarian 78, and NGC 1068
- Author
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Mitchell Revalski, Beena Meena, Francisco Martinez, Garrett E Polack, D Michael Crenshaw, Steven B Kraemer, Nicholas R Collins, Travis C Fischer, Henrique R Schmitt, Judy Schmidt, W Peter Maksym, and Marc Rafelski
- Subjects
Astrophysics - Abstract
Outflows of ionized gas driven by active galactic nuclei (AGN) may significantly impact the evolution of their host galaxies. However, determining the energetics of these outflows is difficult with spatially unresolved observations that are subject to strong global selection effects. We present part of an ongoing study using Hubble Space Telescope and Apache Point Observatory spectroscopy and imaging to derive spatially resolved mass outflow rates and energetics for narrow-line region outflows in nearby AGN that are based on multi-component photoionization models to account for spatial variations in gas ionization, density, abundances, and dust content. This expanded analysis adds Mrk 3, Mrk 78, and NGC 1068, doubling our earlier sample. We find that the outflows contain total ionized gas masses of M ≈ 10(exp 5.5)-10(exp 7.5) M⨀ and reach peak velocities of v ≈ 800-2000 km s(exp -1). The outflows reach maximum mass outflow rates of M(sub OUT) ≈ 3-12 M⨀ yr(exp -1) and encompass total kinetic energies of E ≈ 10(exp 54)-10(exp 56) erg. The outflows extend to radial distances of r ≈ 0.1-3 kpc from the nucleus, with the gas masses, outflow energetics, and radial extents positively correlated with AGN luminosity. The outflow rates are consistent with in situ ionization and acceleration where gas is radiatively driven at multiple radii. These radial variations indicate that spatially resolved observations are essential for localizing AGN feedback and determining the most accurate outflow parameters.
- Published
- 2021
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- View/download PDF
34. TIC 168789840: A Sextuply Eclipsing Sextuple Star System
- Author
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Brian P. Powell, Veselin B. Kostov, Saul A. Rappaport, Tamás Borkovits, Petr Zasche, Andrei Tokovinin, Ethan Kruse, David W. Latham, Benjamin T. Montet, Eric L. N. Jensen, Rahul Jayaraman, Karen A. Collins, Martin Mašek, Coel Hellier, Phil Evans, Thiam-Guan Tan, Joshua E. Schlieder, Guillermo Torres, Alan P. Smale, Adam H. Friedman, Thomas Barclay, Robert Gagliano, Elisa V. Quintana, Thomas L. Jacobs, Emily A. Gilbert, Martti H. Kristiansen, Knicole D. Colón, Daryll M. LaCourse, Greg Olmschenk, Mark Omohundro, Jeremy D. Schnittman, Hans M. Schwengeler, Richard K. Barry, Ivan A. Terentev, Patricia Boyd, Allan R. Schmitt, Samuel N. Quinn, Andrew Vanderburg, Enric Pallé, James Armstrong, George R. Ricker, Roland Vanderspek, S. Seager, Joshua N. Winn, Jon M. Jenkins, Douglas A. Caldwell, Bill Wohler, Bernie Shiao, Christopher J. Burke, Tansu Daylan, and Joel Villaseñor
- Subjects
Astrophysics ,Astronomy - Abstract
We report the discovery of a sextuply eclipsing sextuple star system from TESS data, TIC 168789840, also known as TYC 7037-89-1, the first known sextuple system consisting of three eclipsing binaries. The target was observed in Sectors 4 and 5 during Cycle 1, with light curves extracted from TESS Full Frame Image data. It was also previously observed by the WASP survey and ASAS-SN. The system consists of three gravitationally bound eclipsing binaries in a hierarchical structure of an inner quadruple system with an outer binary subsystem. Follow up observations from several different observatories were conducted as a means of determining additional parameters. The system was resolved by speckle interferometry with a 0 42 separation between the inner quadruple and outer binary, inferring an estimated outer period of ∼2 kyr. It was determined that the fainter of the two resolved components is an 8.217 day eclipsing binary, which orbits the inner quadruple that contains two eclipsing binaries with periods of 1.570 days and 1.306 days. Markov Chain Monte Carlo (MCMC) analysis of the stellar parameters has shown that the three binaries of TIC 168789840 are “triplets,” as each binary is quite similar to the others in terms of mass, radius, and Teff. As a consequence of its rare composition, structure, and orientation, this object can provide important new insight into the formation, dynamics, and evolution of multiple star systems. Future observations could reveal if the intermediate and outer orbital planes are all aligned with the planes of the three inner eclipsing binaries.
- Published
- 2021
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- View/download PDF
35. Silver Nanoparticle Surface Chemistry Determines Interactions with Human Serum Albumin and Cytotoxic Responses in Human Liver Cells
- Author
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Kira M. Fahy, Madeline K. Eiken, Karl V. Baumgartner, Kaitlyn Q. Leung, Sarah E. Anderson, Erik Berggren, Evangelia Bouzos, Lauren R. Schmitt, Prashanth Asuri, and Korin E. Wheeler
- Subjects
General Chemical Engineering ,General Chemistry - Published
- 2023
- Full Text
- View/download PDF
36. METANOIA - Ändere Deinen Sinn - Band 1: Ändere Deinen Sinn
- Author
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Thomas R. Schmitt
- Published
- 2019
37. On Zeros of a Polynomial in a Finite Grid.
- Author
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Anurag Bishnoi, Pete L. Clark, Aditya Potukuchi, and John R. Schmitt
- Published
- 2018
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38. A program to calculate pulse transmission responses through transversely isotropic media.
- Author
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Wei Li, Douglas R. Schmitt, Changchun Zou, and Xiwei Chen
- Published
- 2018
- Full Text
- View/download PDF
39. Industrial energy efficiency potentials: an assessment of three different robot concepts
- Author
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J. Kurilova-Palisaitiene, E. Permin, T. Mannheim, K. Buhse, M. Lorenz, R. Schmitt, B. Corves, and M. Björkman
- Subjects
industrial energy use ,serial robots ,parallel robots ,paragrip ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The rise in energy consumption and the associated costs instigate financial concerns among industrial energy consumers. For industrial processes addressing heating and cooling as well as material transformation, a wide range of energy efficiency measures have been developed and successfully implemented. In contrast to that, most robot-based operations such as pick-and-place motions or assembly tasks still use inefficient standard concepts causing high-energy consumption and high-energy costs. Thanks to a rather low payload-to-weight ratio of new robot designs, such as parallel kinematic or hybrid robot manipulators, a high potential for energy savings is expected. This article identifies potentials for energy saving concerning industrial consumers by assessing three different robot concepts. Based on a literature review, two existing designs for robots – the conventional serial robot and the parallel kinematic robot are analysed and compared with respect to the energy utilised during a typical item placement task. Afterwards, the concept of PARAGRIP, a hybrid of the two presented robot designs is introduced and examined based on simulation regarding its energy consumption. The final results demonstrate significantly different energy consumptions between the robot concepts, identifying potential savings of about 40% in a selected industrial application scenario.
- Published
- 2017
- Full Text
- View/download PDF
40. Perceived social support declines after deep brain stimulation surgery in patients with Parkinson’s disease
- Author
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Sydney Spagna, Asra Askari, Kara J. Wyant, Laura Zeitlin, Taylor R. Schmitt, Carol C. Persad, Xiru Lyu, Parag G. Patil, and Kelvin L. Chou
- Subjects
Psychiatry and Mental health ,Neurology ,Neurology (clinical) ,Biological Psychiatry - Published
- 2022
- Full Text
- View/download PDF
41. Analyses of the relationship between the concentrations of essential trace elements in total mixed ration and faeces samples from Holstein Friesian dairy cows and the estimation of faeces reference values
- Author
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R, Staufenbiel, R, Schmitt, A E, Müller, and L, Staufenbiel
- Subjects
Molybdenum ,Feces ,Selenium ,Zinc ,General Veterinary ,Reference Values ,Iron ,Animals ,Cattle ,Female ,Cobalt ,Copper ,Trace Elements - Abstract
Undersupply and oversupply of dairy cows with essential trace elements should be avoided from the point of view of animal health and environmental pollution. The aim of the study was to proof the results faecal analyzes on the nutritional supply situation with essential trace elements in comparison to measurements from total mixed ration (TMR) analyses. Concentrations of iron (Fe), copper (Cu), zinc (Zn), Mangan (Mn), selenium (Se), cobalt (Co), molybdenum (Mo) were measured as representative multicentric random sample in 574 TMR, 600 pooled faecal and blood samples from dairy cows. Trace elements, Fe in 0 %, Se 18 %, Zn 43 %, Cu 52 %, Co 53 % and Mn 59 %, were within the target range. Undersupply was found in 0 to 8 % and an oversupply in 39 to 100 % of the TMR samples. The tolerance limit for Fe was exceeded in 11 % and for Mo in 13 %. The results indicate the need for optimized ration design. The trace element concentrations in the faecal samples varied over a wide range. Results of pooled faecal samples (n=10 per pool) corresponded closely with the mean values calculated from the individual samples (r20,9). Correlation between element concentrations in the TMR and faecal samples for Fe (r=0,687), Cu (r=0,675), Zn (r=0,635), Mn (r=0,656), Se (r=0,573), Co (r=0,795), and Mo (r=0,708) were highly significant. No correlations were detected between the element concentrations in the TMR and in the blood samples. The regression analyzes showed a highly significant linear adjustment of the measured value distribution around the regression lines over the entire value range including the zero point. Reference values were calculated for the faecal concentrations of Cu, Zn, Mn, Se and Co. Tolerance reference limits in the TMR were calculated for the faecal concentrations of Fe and Mo. The trace element concentrations in the TMR samples reflect the nutritional supply situation. Knowledge of the nutritional supply situation of the herd is of great importance for the stock management of dairy cow. Fecal sample analyzes can be used as an alternative to TMR examinations to assess the nutritional supply situation.Unter- und Überversorgungen von Milchkühen mit essenziellen Spurenelementen sind aus Sicht der Tiergesundheit und einer Umweltbelastung zu vermeiden. Untersuchungsziel war die Prüfung der Aussage von Kotanalysen zur Beurteilung der nutritiven Versorgungslage mit essenziellen Spurenelementen über einen Vergleich mit den Messwerten aus den TMR-(Totale Mischration)-Analysen. In einer repräsentativen multizentrischen Zufallsstichprobe wurden in 574 TMR-Proben und 600 gepoolten Kotproben von Milchkühen die Konzentrationen von Eisen (Fe), Kupfer (Cu), Zink (Zn), Mangan (Mn), Selen (Se), Kobalt (Co), Molybdän (Mo) gemessen sowie Blutproben untersucht. Der Zielbereich für den Spurenelementgehalt in der TMR wurde für Fe in 0 %, Se 18 %, Zn 43 %, Cu 52 %, Co 53 % und Mn 59 % eingehalten. Der Bereich einer Unterversorgung wurde in 0 bis 8 %, der Bereich einer Überversorgung in 39 bis 100 % der TMR-Proben festgestellt. Die Toleranzgrenze für Fe wurde in 11 %, für Mo in 13 % überschritten. Die Ergebnisse weisen auf die Notwendigkeit einer optimierten Rationsgestaltung hin. In den Kotproben variierten die Spurenelementkonzentrationen über einen weiten Bereich. Die Analysenergebnisse von gepoolten Kotproben (n=10 pro Pool) stimmten mit einem r2-Wert von über 0,9 eng mit denen aus den Einzelproben berechneten Mittelwerten überein. Zwischen den Elementkonzentrationen in den TMR- und Kotproben bestanden hochsignifikante Korrelationen für Fe (r=0,687), Cu (r=0,675), Zn (r=0,635), Mn (r=0,656), Se (r=0,573), Co (r=0,795) und Mo (r=0,708). Zwischen den Elementkonzentrationen in der TMR und in den Blutproben waren keine Korrelationen nachzuweisen. Die Regressionsanalysen zeigten eine hochsignifikante lineare Anpassung der Messwertverteilung um die Regressionsgeraden über den gesamten Wertebereich unter Einschluss des Nullpunktes. Es wurden für die Kotkonzentrationen an Cu, Zn, Mn, Se und Co Referenzwerte kalkuliert. Für die Kotkonzentrationen an Fe und Mo wurden Referenzgrenzen für die Toleranzgrenzen in der TMR berechnet. Die Spurenelementkonzentrationen in den TMR-Proben spiegeln die nutritive Versorgungslage wider. Für die Bestandsbetreuung von Milchkuhherden ist die Kenntnis der nutritiven Versorgungslage der Herde von grosser Bedeutung. Kotprobenanalysen können alternativ zu TMR-Untersuchungen zur Beurteilung der nutritiven Versorgungslage herangezogen werden.Les sous-approvisionnements et les surapprovisionnements des vaches laitières en oligo-éléments essentiels doivent être évités du point de vue de la santé animale et de la pollution de l’environnement. L’objectif de cette étude était de vérifier la pertinence des analyses de fèces pour évaluer l’apport nutritionnel en oligo-éléments essentiels en les comparant aux valeurs mesurées dans les analyses de RTM (ration totale mélangée). Dans un échantillon aléatoire multicentrique représentatif, les concentrations de fer (Fe), de cuivre (Cu), de zinc (Zn), de manganèse (Mn), de sélénium (Se), de cobalt (Co) et de molybdène (Mo) ont été mesurées dans 574 échantillons de RTM et 600 échantillons de fèces regroupés de vaches laitières et des échantillons de sang ont été analysés. La plage cible pour la teneur en oligo-éléments dans la RTM a été respectée pour Fe à 0 %, Se à 18 %, Zn à 43 %, Cu à 52 %, Co à 53 % et Mn à 59 %. La plage de sous-alimentation a été constatée dans 0 à 8 % des échantillons de RTM, la plage de suralimentation dans 39 à 100 %. La limite de tolérance pour le Fe a été dépassée dans 11 %, pour le Mo dans 13 %. Ces résultats indiquent la nécessité d’optimiser les rations. Dans les échantillons de fèces, les concentrations en oligo-éléments variaient sur une large plage. Les résultats d’analyse des échantillons de fèces regroupés (n=10 par pool) correspondaient étroitement, avec une valeur r2 supérieure à 0,9, aux valeurs moyennes calculées à partir des échantillons individuels. Il y avait des corrélations très significatives entre les concentrations d’éléments dans les échantillons de RTM et de fèces pour Fe (r=0,687), Cu (r=0,675), Zn (r=0,635), Mn (r=0,656), Se (r=0,573), Co (r=0,795), et Mo (r=0,708). Aucune corrélation n’a pu être établie entre les concentrations d’éléments dans le RTM et dans les échantillons de sang. Les analyses de régression ont montré un ajustement linéaire hautement significatif de la distribution des valeurs mesurées autour de la droite de régression sur l’ensemble de la plage de valeurs, y compris le point zéro. Des valeurs de référence ont été calculées pour les concentrations de Cu, Zn, Mn, Se et Co dans les fèces. Pour les concentrations de Fe et Mo dans les fèces, des limites de référence ont été calculées pour les limites de tolérance dans la RTM. Les concentrations en oligo-éléments dans les échantillons de RTM reflètent la situation nutritionnelle. Pour le suivi des troupeaux de vaches laitières, il est très important de connaître l’état nutritionnel du troupeau. Les analyses d’échantillons de fèces peuvent être utilisées comme alternative aux analyses de RTM pour évaluer la situation nutritionnelle.L’insufficiente o eccessivo apporto di oligoelementi essenziali alle vacche da latte deve essere evitato dal punto di vista della salute degli animali e dell’inquinamento ambientale. Lo scopo dello studio è quello di verificare i risultati delle analisi fecali sulla situazione dell’apporto nutrizionale di oligoelementi essenziali rispetto alle misurazioni effettuate con le analisi della razione mista totale TMR (Total Mixed Ration). Le concentrazioni di ferro (Fe), rame (Cu), zinco (Zn), manganese (Mn), selenio (Se), cobalto (Co) e molibdeno (Mo) sono state misurate come campione rappresentativo multicentrico casuale in 574 TMR, 600 campioni fecali e di sangue nelle vacche da latte. L’intervallo di valori target per il contenuto di oligoelementi è stato raggiunto per Fe 0 %, Se 18 %, Zn 43 %, Cu 52 %, Co 53 % e Mn 59 %. Una sotto-alimentazione è stata riscontrata dallo 0 all’8 % e una sovra-alimentazione dal 39 al 100 % dei campioni di TMR. Il limite di tolleranza per il Fe è stato superato nell’11 % e per il Mo nel 13 %. I risultati indicano la necessità di ottimizzare la pianificazione della razione. Le concentrazioni di oligoelementi nei campioni fecali oscillavano in un ampio intervallo. I risultati dei campioni fecali in pool (n=10 per pool) corrispondevano strettamente ai valori medi calcolati dai singoli campioni (r20,9). Le relazioni tra le concentrazioni di elementi nel TMR e nei campioni fecali erano altamente significative per Fe (r=0,687), Cu (r=0,675), Zn (r=0,635), Mn (r=0,656), Se (r=0,573), Co (r=0,795) e Mo (r=0,708). Non sono state rilevate relazioni tra le concentrazioni di elementi nel TMR e nei campioni di sangue. Le analisi di regressione hanno mostrato un adattamento lineare altamente significativo della distribuzione dei valori misurati intorno alle linee di regressione per l’intero intervallo di valori, compreso il punto zero. Sono stati calcolati valori di riferimento per le concentrazioni fecali di Cu, Zn, Mn, Se e Co. Per le concentrazioni fecali di Fe e Mo sono stati calcolati i limiti di tolleranza di riferimento nel TMR. Le concentrazioni di oligoelementi nei campioni di TMR riflettono la situazione dell’approvvigionamento nutrizionale. La conoscenza della situazione nutrizionale della mandria è di grande importanza per la gestione delle vacche da latte. L’analisi dei campioni fecali può essere utilizzata come alternativa all’esame del TMR per valutare la situazione dell’apporto nutrizionale.
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- 2022
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42. Warning's Second Theorem with restricted variables.
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Pete L. Clark, Aden Forrow, and John R. Schmitt
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- 2017
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43. New methods to attack the Buratti-Horak-Rosa conjecture.
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M. A. Ollis, Anita Pasotti, Marco Antonio Pellegrini, and John R. Schmitt
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- 2021
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44. Challenges and trends in manufacturing measurement technology – the 'Industrie 4.0' concept
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D. Imkamp, J. Berthold, M. Heizmann, K. Kniel, E. Manske, M. Peterek, R. Schmitt, J. Seidler, and K.-D. Sommer
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Technology - Abstract
Strategic considerations and publications dealing with the future of industrial production are significantly influenced these days by the concept of “Industrie 4.0”. For this reason the field of measurement technology for industrial production must also tackle this concept when thinking about future trends and challenges in metrology. To this end, the Manufacturing Metrology Roadmap 2020 of the VDI/VDE Society for Measurement and Automatic Control (GMA) was published in 2011 (VDI/VDE-GMA, 2011; Imkamp et al., 2012). The content of this roadmap is reviewed and extended here, covering new developments in the field of the Industrie 4.0 concept and presented with expanded and updated content.
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- 2016
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45. Characterisation and improvement of j(O1D) filter radiometers
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B. Bohn, D. E. Heard, N. Mihalopoulos, C. Plass-Dülmer, R. Schmitt, and L. K. Whalley
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Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
Atmospheric O3 → O(1D) photolysis frequencies j(O1D) are crucial parameters for atmospheric photochemistry because of their importance for primary OH formation. Filter radiometers have been used for many years for in situ field measurements of j(O1D). Typically the relationship between the output of the instruments and j(O1D) is non-linear because of changes in the shape of the solar spectrum dependent on solar zenith angles and total ozone columns. These non-linearities can be compensated for by a correction method based on laboratory measurements of the spectral sensitivity of the filter radiometer and simulated solar actinic flux density spectra. Although this correction is routinely applied, the results of a previous field comparison study of several filter radiometers revealed that some corrections were inadequate. In this work the spectral characterisations of seven instruments were revised, and the correction procedures were updated and harmonised considering recent recommendations of absorption cross sections and quantum yields of the photolysis process O3 → O(1D). Previous inconsistencies were largely removed using these procedures. In addition, optical interference filters were replaced to improve the spectral properties of the instruments. Successive determinations of spectral sensitivities and field comparisons of the modified instruments with a spectroradiometer reference confirmed the improved performance. Overall, filter radiometers remain a low-maintenance alternative of spectroradiometers for accurate measurements of j(O1D) provided their spectral properties are known and potential drifts in sensitivities are monitored by regular calibrations with standard lamps or reference instruments.
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- 2016
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46. A Tale of Two Eastwoods: Iconographic Persona and Rhetorical Ethos in Clint Eastwood's 'Halftime in America' and RNC 2012 Address
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Casey R. Schmitt
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ethos, rhetoric, Clint Eastwood, iconographic persona, RNC, Halftime in America ,Psychology ,BF1-990 - Abstract
In 2012, actor-director Clint Eastwood was twice the special focus of attention in America, not for his acting or directing accomplishments but for a pair of uniquely prominent and instantly memorable televised ideological statements. His scripted appearance in a two-minute Super Bowl XLVI halftime commercial for the Chrysler Group was widely lauded while his address to the Republican National Convention in Tampa, Florida, later that year remains to this day an object of pointed criticism and widespread ridicule. This essay uses side-by-side rhetorical analyses of the two examples—this tale of two Eastwoods—to demonstrate the import of expectation and rhetorical persona in an age of modern, national, and global celebrity. The comparison illustrates how a massively famous speaker whose mediated public image has achieved highly symbolically status may both benefit from and struggle with what I call “iconographic persona.” The essay argues that celebrity speakers and spokespersons in modern societies must seek congruence between iconographic persona and rhetorical ethos. In Eastwood's case, the expectations and associations met and solidified by the Chrysler ad went unmet in the RNC address, and thus two appeals by the same speaker resulted in two very different receptions. In conversation with Amossy, Halloran, and Butterworth in “connecting” contemporary discussions of rhetoric, celebrity, nationalism, and sport, this essay sheds light on the unique rhetorical position of the celebrity speaker in the political or activist spheres.
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- 2016
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47. Digital Methods of Delivering Education and Training in Neuropsychology
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Ryan Van Patten, John A Bellone, Taylor R Schmitt, Leslie Gaynor, and Cady Block
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Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Neuropsychology ,Educational Status ,Humans ,Learning ,Clinical Competence ,General Medicine ,Neuropsychological Tests - Abstract
Objective High quality and accessible education is crucial to secure the future of neuropsychology. Recent and ongoing advancements include the creation of a taxonomy of education and training, progress in delineating relevant competencies, and an update to the Houston Conference Guidelines. Meanwhile, there is also potential for growth in digital methods of delivering education such as podcasts, webinars, and social media platforms. This paper aims to review the evidence for these three methods and to provide recommendations for implementing them across the continuum of training in neuropsychology, from graduate school through postdoctoral fellowship and continuing education. Method We reviewed the literature on podcasts, webinars, and social media platforms as educational tools that may be applied to improve learning of brain–behavior concepts and clinical skills. Specifically, we (a) introduce and describe each method, (b) discuss benefits and drawbacks, (c) review the literature on satisfaction and learning outcomes, and (d) provide suggestions for implementation in neuropsychology training programs. Results Podcasts and webinars have strong evidence for satisfaction and moderate support for improving learning outcomes, with the learning outcome literature suggesting equivalency between podcasts/webinars and traditional methods of education. Social media platforms are associated with high satisfaction, but learning outcome data are scarce. Conclusions Evidence for podcasts and webinars is sufficient to support implementation into neuropsychology education, whereas social media platforms should be used more cautiously. We provide recommendations of select instances in which trainees and educators can use these methods to improve education in neuropsychology.
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- 2022
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48. Current Applications of Polycaprolactone as a Scaffold Material for Heart Regeneration
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Phillip R. Schmitt, Kiera D. Dwyer, and Kareen L. K. Coulombe
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Biomaterials ,Tissue Scaffolds ,Polyesters ,Biochemistry (medical) ,Biomedical Engineering ,Regeneration ,Myocytes, Cardiac ,General Chemistry - Abstract
Despite numerous advances in treatments for cardiovascular disease, heart failure (HF) remains the leading cause of death worldwide. A significant factor contributing to the progression of cardiovascular diseases into HF is the loss of functioning cardiomyocytes. The recent growth in the field of cardiac tissue engineering has the potential to not only reduce the downstream effects of injured tissues on heart function and longevity but also re-engineer cardiac function through regeneration of contractile tissue. One leading strategy to accomplish this is via a cellularized patch that can be surgically implanted onto a diseased heart. A key area of this field is the use of tissue scaffolds to recapitulate the mechanical and structural environment of the native heart and thus promote engineered myocardium contractility and function. While the strong mechanical properties and anisotropic structural organization of the native heart can be largely attributed to a robust extracellular matrix, similar strength and organization has proven to be difficult to achieve in cultured tissues. Polycaprolactone (PCL) is an emerging contender to fill these gaps in fabricating scaffolds that mimic the mechanics and structure of the native heart. In the field of cardiovascular engineering, PCL has recently begun to be studied as a scaffold for regenerating the myocardium due to its facile fabrication, desirable mechanical, chemical, and biocompatible properties, and perhaps most importantly, biodegradability, which make it suitable for regenerating and re-engineering function to the heart after disease or injury. This review focuses on the application of PCL as a scaffold specifically in myocardium repair and regeneration and outlines current fabrication approaches, properties, and possibilities of PCL incorporation into engineered myocardium, as well as provides suggestions for future directions and a roadmap toward clinical translation of this technology.
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- 2022
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49. Effects of CO 2 phase state on the seismological properties of porous materials: implications for seismic monitoring of volcanic hazards and sequestered carbon
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Douglas R. Schmitt, Gabriela Dávila, Helen Yam, Gautier Njiekak, and Randolf Kofman
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Geology ,Ocean Engineering ,Water Science and Technology - Abstract
Time-lapse seismic monitoring is a key component in the geological sequestration of greenhouse gases. Currently, a lack of understanding of the influence of injected CO 2 on rocks’ geophysical signatures is reported. Using a novel ultrasonic experimental system, we measured the variations in the longitudinal (P) and transverse (S) elastic wave speeds of a CO 2 -saturated porous medium at different pressure and temperature conditions around the CO 2 critical point. The results show that both P- and S-wave speeds, corrected to seismic frequencies, decreased by more than 4.5% across the CO 2 gas to liquid and gas to supercritical states, primarily as a consequence of CO 2 density increase. This study provides a-20 firm basis for the use of seismological methods in monitoring sequestered CO 2 ; although the abruptness, and hence remote seismic detectability, depends on which phase boundary is crossed. Further, these measurements also allow us to compare observations to frequency-dependent wave propagation theory. The observed wave speeds mostly align with those calculated at 1 MHz using the Biot theory for both CO 2 and H 2 O saturated states. However, the observed and calculated wave speeds diverge above the phase transition in some of the tests, possibly due to the kinetics of the phase transition within a porous medium. As such, aside from the direct utility in providing information on the expected seismic responses, the CO 2 provides a highly tunable fluid that can be advantageous for experimental studies.
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- 2023
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50. Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γΔ5 mice drives acute liver injury
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Lauren G. Poole, Lauren R. Schmitt, Anthony Schulte, Dafna J. Groeneveld, Holly M. Cline, Yaqiu Sang, Woosuk S. Hur, Alisa S. Wolberg, Matthew J. Flick, Kirk C. Hansen, and James P. Luyendyk
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Hematology - Published
- 2023
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