1. Clinical outcomes of sofosbuvir/velpatasvir in hepatitis C virus-infected patients with end-stage renal disease on maintenance hemodialysis
- Author
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Li-xia Yu, Jian-ming Ye, Xiao-ya Yin, Qi-feng Liu, and Qiang Sun
- Subjects
hemodialysis ,hepatitis c ,end-stage renal disease ,Internal medicine ,RC31-1245 - Abstract
Objective To evaluate the safety and efficacy of 12-week sofosbuvir/velpatasvir (SOF/VEL) in chronic hepatitis C (CHC) patients with end-stage renal disease (ESRD) on maintenance hemodialysis (MHD) in a real-world setting. Methods From October 10, 2020 to January 28, 2021, 18 CHC patients received full-dose sofosbuvir (400 mg) plus velpatasvir (100 mg) once daily for 12 weeks. HCV RNA quantification, hepaticorenal function and electrolytes were assessed at baseline, end of treatment (EOT) and Week 12/48 after discontinuing therapy. Primary outcome was sustained virological response at Week 12 post-treatment (SVR12, HCV RNA negative). Safety profile was evaluated by monitoring adverse events and laboratory parameters. Results A total 18 treatment-naïve CHC patients on MHD were recruited. And 14 of them underwent MHD for primary chronic glomerulonephritis. All of them were of HCV genotype 1b. One patient developed compensated cirrhosis. The average time of HCV infection was (150.6±47.6)month. Baseline HCV-RNA ranged from (4.61×106 )U/L to (4.47×109)U/L. And 12-week SOF/VEL treatment was completed and HCV-RNA stayed negative at EOT and PTW12/48. Significant reductions occurred in ALT [19.0(13.8, 24.0)U/L vs 9.0(8.0, 10.0)U/L] and AST [18.0(12.5, 21.0)U/L vs 10.0(8.0, 12.0)U/L] from baseline to PTW48 (P
- Published
- 2023
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